Fungal Genomics

at Utrecht University

Enrichment of functional annotation terms

This tools allows you to determine whether there are any over-represented functional annotation terms in a set of proteins. For example, you have a set of genes that is differentially expressed in a certain condition. It would be interesting to know what is special about those genes. Are there any PFAM domains that are over-represented in that set of genes, when compared to the rest of the genome? And are they more likely to contain a secretion signal?

Input data

List of protein IDs, one per line*

Functional annotation type*

PFAM domains

Gene Ontology (GO)

Secretion signal (signalp 6)

Protein localization (deeploc)

Transmembrane domains (TMHMM)

Transcription Factors

Secondary Metabolism gene clusters

Carbohydrate-active Enzymes (CAZymes)

Cutoff for the p-value*

Note: the p-values are automatically corrected using the FDR method within the annotation type.

Minimum number or genes per annotation term*

If the annotation term has fewer genes than this number, it will be excluded from the analysis.

Output*

Table on website

Download as Excel file

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