April 16, 2021
Peter Jan Vonk published a new paper about the epigenetic landscape during mushroom development. He performed ChIP-Seq on lysine 4 dimethylated histone H3, which is a marker for transcriptionally active DNA. Overall, the epigenetic landscape is similar between monokaryons (a lifestage that does not form mushrooms) and primordia (early mushroom development). However, clear differences were also seen. For example in the case of two transcription factors. Indeed, when these TFs were deleted, mushroom development was stalled.
Oct. 29, 2020
This month 4 new students have started their research internship for their Master program. Welcome Brandon, Janieke, Jelle and Tom. Furthermove, Ryan will start in November. Good luck!
July 25, 2020
This week we launched the new website for the Fungal Genomics group. The most important addition is the Genome Portals. These allow you to analyze the genomes that we have sequenced and annotated (or have collaborated on). The current set of tools include Blast, a genome browser, functional annotations, and an enrichment analysis tool. More tools will be added later!
June 5, 2020
A new paper from the collaboration with the lab of Charissa de Bekker about Ophiocordyceps and zombie ants. The genome of Ophiocordyceps camponoti-floridani was sequenced, annotated, and analyzed. Moreover, an expression analysis during behavior modification gave a lot of new insights into what is really going on during this fascinating process.
Jan. 5, 2020
We have a new lab member: Yuanyuan Wang. She is a visiting PhD student with a CSC grant from China, and will work on the regulation of mushroom development for 1 year.
Oct. 22, 2019
We started a new research line: the defense of mushroom-forming fungi against their fungal pathogens. It is funded by a VIDI grant by the Dutch Research Council (NWO). Erik Beijen is the first PhD student who will work on the project.
May 21, 2019
Peter Jan Vonk has published his method to dramatically increase the efficiency of gene deletion using pre-assembled ribonucleoproteins
Oct. 11, 2018
Peter Jan Vonk published a paper about the evolution of homeodomain transcription factors. This class of TFs plays several important roles in (multicellular) development in many fungi across the fungal kingdom.
Oct. 2, 2017
Today our paper was published in Scientific Reports, which was the result of the ongoing collaboration with the group of Charissa de Bekker at the University of Florida.
We sequenced and annotated five genomes of Ophiocoryceps species that can infect ants and modify their behavior. Comparative genomics and transcriptomics revealed novel candidate genes that may be involved in this behavior modification.
The genomes can be browsed interactively by clicking on Genome Portals in the menu bar.
Sept. 10, 2016
Robin Ohm has been awarded a Starting Grant by the European Research Council (ERC). The grant of 1.5 million euros allows the group to study the genetics of mushroom development using the model system Schizophyllum commune.