Fungal Genomics

Agaricus bisporus var bisporus H39 Agaricus bisporus var bisporus H97 Agaricus bisporus var burnettii H119p4 Aspergillus niger CBS 112.32 Aspergillus niger CBS 113.50 Aspergillus niger CBS 115988 Aspergillus niger CBS 115989 Aspergillus niger CBS 118.52 Aspergillus niger CBS 124.48 Aspergillus niger CBS 131.52 Aspergillus niger CBS 133816 Aspergillus niger CBS 147320 Aspergillus niger CBS 147321 Aspergillus niger CBS 147322 Aspergillus niger CBS 147323 Aspergillus niger CBS 147324 Aspergillus niger CBS 147343 Aspergillus niger CBS 147344 Aspergillus niger CBS 147345 Aspergillus niger CBS 147346 Aspergillus niger CBS 147347 Aspergillus niger CBS 147352 Aspergillus niger CBS 147353 Aspergillus niger CBS 147371 Aspergillus niger CBS 147482 Aspergillus niger CBS 630.78 Aspergillus niger CBS 769.97 Niveomyces coronatus CBS 149186 Ophiocordyceps australis 1348a (Ghana) Ophiocordyceps australis map64 (Brazil) Ophiocordyceps camponoti-floridani Ophiocordyceps camponoti-rufipedis Ophiocordyceps kimflemingae Ophiocordyceps subramaniannii Penicillium roqueforti DTO002I6 Penicillium roqueforti DTO003C3 Penicillium roqueforti DTO003H1 (CBS 147308) Penicillium roqueforti DTO006G1 Penicillium roqueforti DTO006G7 Penicillium roqueforti DTO012A1 Penicillium roqueforti DTO012A2 (CBS 147309) Penicillium roqueforti DTO012A6 (CBS 147310) Penicillium roqueforti DTO012A7 Penicillium roqueforti DTO012A8 Penicillium roqueforti DTO012A9 Penicillium roqueforti DTO013E5 Penicillium roqueforti DTO013F2 Penicillium roqueforti DTO013F5 (CBS 147311) Penicillium roqueforti DTO027I6 Penicillium roqueforti DTO032C6 Penicillium roqueforti DTO039G3 Penicillium roqueforti DTO046C5 Penicillium roqueforti DTO070G2 (CBS 147317) Penicillium roqueforti DTO081F9 (CBS 147318) Penicillium roqueforti DTO101D6 (CBS 147325) Penicillium roqueforti DTO102I9 (CBS 147326) Penicillium roqueforti DTO126G2 (CBS 147330) Penicillium roqueforti DTO127F7 (CBS 147331) Penicillium roqueforti DTO127F9 (CBS 147332) Penicillium roqueforti DTO130C1 (CBS 147333) Penicillium roqueforti DTO163C3 (CBS 147337) Penicillium roqueforti DTO163F5 (CBS 147338) Penicillium roqueforti DTO163G4 (CBS 147339) Penicillium roqueforti DTO265D5 (CBS 147372) Penicillium roqueforti DTO369A1 (CBS 147354) Penicillium roqueforti DTO375B1 (CBS 147355) Penicillium roqueforti DTO377G2 (LCP 96.3914a) Penicillium roqueforti LCP96 04111 Rhodonia placenta FPRL280 Torrubiellomyces zombiae CBS 149187

General Properties

Protein ID	Pro_DTO377G3_2|g9666.t1
Gene name
Location	scaffold_58:17272..21228
Strand	+
Gene length (bp)	3956
Transcript length (bp)	3411
Coding sequence length (bp)	3411
Protein length (aa)	1137

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PFAM Domains

PFAM Domain ID	Short name	Long name	E-value	Start	End
PF00654	Voltage_CLC	Voltage gated chloride channel	1.8E-88	253	634
PF12243	CTK3	CTD kinase subunit gamma CTK3	3.6E-50	893	1013
PF12350	CTK3_C	CTD kinase subunit gamma CTK3 C-terminus	1.4E-16	1059	1120

GO

GO Term	Description	Terminal node
GO:0005247	voltage-gated chloride channel activity	Yes
GO:0016020	membrane	Yes
GO:0055085	transmembrane transport	Yes
GO:0006821	chloride transport	Yes
GO:0015698	inorganic anion transport	No
GO:0015267	channel activity	No
GO:0022836	gated channel activity	No
GO:0006820	anion transport	No
GO:0051234	establishment of localization	No
GO:0022857	transmembrane transporter activity	No
GO:0005575	cellular_component	No
GO:0015108	chloride transmembrane transporter activity	No
GO:0022832	voltage-gated channel activity	No
GO:0008150	biological_process	No
GO:0006810	transport	No
GO:0005253	anion channel activity	No
GO:0005254	chloride channel activity	No
GO:0003674	molecular_function	No
GO:0022803	passive transmembrane transporter activity	No
GO:0008308	voltage-gated anion channel activity	No
GO:0006811	ion transport	No
GO:0005216	ion channel activity	No
GO:0015103	inorganic anion transmembrane transporter activity	No
GO:0015075	ion transmembrane transporter activity	No
GO:0051179	localization	No
GO:0015318	inorganic molecular entity transmembrane transporter activity	No
GO:0005215	transporter activity	No
GO:0110165	cellular anatomical entity	No
GO:0008509	anion transmembrane transporter activity	No
GO:0009987	cellular process	No
GO:0005244	voltage-gated ion channel activity	No

SignalP

[Help with interpreting these statistics]

SignalP signal predicted	Location (based on Ymax)	D score (significance: > 0.45)
No	1 - 46	0.45

Transmembrane Domains

Domain #	Start	End	Length
1	160	182	22
2	238	260	22
3	344	366	22
4	416	438	22
5	458	480	22
6	511	533	22
7	540	562	22
8	582	599	17
9	606	628	22

Transcription Factor Class

(None)

Expression data

Analysis 1: Genome-wide gene expression in conidia of Penicillium roqueforti during growth at various temperatures and for various amounts of time. Published in Punt et al., 2020.

Expression values

Label	Description	Expression (RPKM)	Confidence interval (low)	Confidence interval (high)
3d_25C	Three days - 25 degrees Celsius	33.37	20.46	46.27
5d_25C	Five days - 25 degrees Celsius	30.09	18.33	41.85
7d_25C	Seven days - 25 degrees Celsius	27.99	17.07	38.91
10d_25C	Ten days - 25 degrees Celsius	27.77	16.91	38.62
7d_15C	Seven days - 15 degrees Celsius	30.41	18.63	42.19
7d_30C	Seven days - 30 degrees Celsius	29.28	17.78	40.78

Differential expression

Label1	Label2	Q-value	Significant difference
3d_25C	5d_25C	0.719289	no
3d_25C	7d_25C	0.493904	no
3d_25C	7d_15C	0.744517	no
3d_25C	7d_30C	0.637317	no
3d_25C	10d_25C	0.462537	no
5d_25C	7d_25C	0.814783	no
5d_25C	7d_15C	0.976712	no
5d_25C	7d_30C	0.936747	no
5d_25C	10d_25C	0.789183	no
7d_25C	7d_15C	0.775634	no
7d_25C	7d_30C	0.892116	no
7d_25C	10d_25C	0.983223	no
7d_15C	7d_30C	0.909237	no
7d_15C	10d_25C	0.757026	no
7d_30C	10d_25C	0.870761	no

Sequences

Type of sequence	Sequence
Locus	Download genbank file of locus The gene with 5 kb flanks (if sufficient flanking sequence is available). For use in cloning design programs. NOTE: features (genes or exons) that are only partially contained within the sequence are completely excluded.
Protein	>Pro_DTO377G3_2|g9666.t1 MSGQGSGGEGQSGTQLGSDQDILQPQEVNREAERLHEPISFKRKQKQRSRFSLSNLLSPPSGGSDTGFGSPAPQG GQNGDASPLDPYAPIGLNSGAEASKDGAPLDWYVEGPGRRVGYDDFTAIDWIYEYTKERQRKRLLYSSGQGLLGH ARRLLDASNVWLVLIATGIAVGIIAASIDIATDWLGDLKSGYCKNGSGGGKFYLNKSFCCWGLDDQSKCLDWTPW GNALGAKSSGGAYTVGYVFYVSFSVFFAACACFLVRNYAVYARHSGIPEIKTILGGTVIRHFMGPWTLAIKSLGL CLSVASGLWLGKEGPLVHVACCCANILMKPFESLKGNEARKREVLSAAAAAGISVAFGAPIGGVLFSLEQLSYYF PDKTMWQSFVCAMVAAVTLQALNPFRTGKIVLYQVTYTRGWHRFEIIPFIILGIIGGLYGAFLIRLNTKVTKWRR ARTSSRPIIEVVVVALITALINYPNHFMRAQNSELVQSLFAECNSVTYDRFGLCATGSASIGVAIYLVVAALLAF FLASLTFGLEIPAGIILPSVAIGALYGRALGIIVRLWQESYPQAFLFSRCEPDIPCVTPGLYAIIGAAAALGGAT RMTLSIVVIMFELTGALTYVIPIMIAVMLSKWCGDIFGKRGIYESWIRLNEYPFLDHRDDTTPPDVSANRVMTTV DDISIITATGHTIASIRNLLANTTYRGFPIVSDTSSPVLLGYITRNEISFALKYSTSGTARNLSDETQVFFSHQP FADPSDTLDLRPWMDQTPMTLNSNITFLIVLKMFQRLGLRYVLFANKGILQGLLTKKDVWSVLNGVEIRREEALR DEEYQDFENRNEAEEQVIEIKLRLRPTAFLTPHISVGFLKLTALISTGTATDLPTLEEAITPEDKMMIDPFEVRM RFTTQLQHLSAAVTSSQKAAHYALKYRDLDEDLHSCILEQLERNNMNNRANIMYFIEHLCEMAIKENYLPYVRMM QRDILRVVDSVVPPDGTGAANVKHVRHVLNGLRAKEVLSAETVAEIDAALKDRDSHPSHLDLEHEEGPEGGSKSK SEKPQLRLDKKQIEQRIEEDRERNKRQRESMWAMTGSDQDEYNQMWEELSPIGEDDFIRSREEALERAECFRKHE EFYKNLYGINE*
Coding	>Pro_DTO377G3_2|g9666.t1 ATGAGTGGTCAGGGCTCAGGTGGCGAGGGCCAATCTGGGACGCAACTAGGATCTGATCAAGACATCCTTCAGCCT CAAGAAGTGAATCGGGAAGCCGAGAGGTTACATGAGCCGATCTCCTTCAAGCGAAAACAAAAACAACGATCACGG TTCAGTCTATCTAACCTTCTCTCCCCTCCCTCCGGCGGATCGGATACTGGCTTTGGCTCTCCGGCGCCGCAAGGT GGTCAGAACGGCGATGCATCGCCACTCGATCCTTACGCGCCGATAGGGCTCAATAGTGGTGCTGAAGCCTCAAAA GATGGCGCGCCATTGGACTGGTACGTGGAAGGCCCAGGACGACGTGTGGGCTACGACGACTTCACTGCTATCGAT TGGATCTACGAGTATACCAAGGAGCGGCAAAGGAAACGGCTTCTTTACTCGAGTGGACAGGGTCTATTGGGCCAT GCTCGTCGACTGCTTGACGCAAGCAATGTCTGGTTAGTGTTGATTGCGACAGGCATTGCTGTAGGAATAATCGCT GCTTCTATCGATATTGCAACGGATTGGCTAGGTGACCTGAAGTCCGGATATTGCAAAAATGGAAGTGGAGGTGGC AAGTTTTATCTCAACAAGAGCTTTTGCTGCTGGGGTCTCGATGATCAATCTAAGTGTTTAGACTGGACACCTTGG GGAAATGCATTAGGCGCAAAGTCCAGTGGAGGGGCATATACGGTTGGATATGTCTTTTATGTTTCATTTTCGGTT TTCTTTGCTGCATGTGCTTGCTTCTTGGTGCGAAATTATGCCGTTTATGCTAGACACAGTGGAATCCCCGAGATA AAAACGATCCTCGGTGGAACTGTCATCCGACATTTCATGGGACCATGGACACTTGCCATTAAATCACTGGGCCTG TGTCTTTCTGTGGCTTCCGGTCTATGGCTAGGTAAAGAGGGCCCACTTGTGCATGTTGCATGCTGTTGCGCGAAT ATCCTGATGAAACCTTTTGAAAGCCTGAAAGGCAATGAAGCACGCAAACGAGAGGTTCTTTCTGCGGCTGCTGCA GCAGGTATATCAGTCGCATTCGGGGCACCCATCGGAGGTGTTCTTTTTAGTTTGGAGCAACTTTCATATTATTTT CCCGACAAGACAATGTGGCAAAGCTTTGTCTGTGCCATGGTCGCAGCTGTCACTTTGCAAGCCTTGAACCCATTC CGGACAGGTAAAATTGTGCTGTATCAAGTCACCTACACTCGAGGCTGGCACCGCTTTGAGATCATCCCGTTCATT ATTCTTGGCATCATTGGCGGCCTCTACGGTGCATTCCTCATCCGCCTGAATACTAAAGTCACCAAATGGAGGCGA GCTCGGACTTCCTCTCGACCAATCATCGAAGTGGTTGTCGTGGCTCTCATTACAGCTTTGATCAACTATCCAAAT CACTTCATGCGGGCTCAGAACTCGGAGCTTGTCCAGTCGCTGTTCGCCGAGTGCAACAGTGTGACATATGATCGA TTTGGTCTCTGCGCCACGGGATCTGCCTCAATCGGCGTGGCAATCTACCTGGTCGTTGCTGCTTTACTTGCCTTT TTCTTGGCTTCCTTGACATTTGGACTTGAGATTCCTGCGGGTATCATCCTTCCTTCGGTCGCTATCGGTGCTCTT TACGGGCGTGCTCTGGGCATTATAGTTCGCTTGTGGCAAGAATCTTATCCGCAAGCATTCCTGTTTAGCAGGTGC GAGCCAGACATTCCATGTGTCACACCTGGCTTATACGCAATTATCGGGGCTGCTGCTGCTCTTGGTGGTGCTACT CGAATGACTTTGTCAATTGTCGTTATCATGTTCGAATTGACCGGCGCGCTGACCTACGTCATCCCGATCATGATT GCTGTGATGCTGTCCAAGTGGTGTGGTGACATCTTCGGGAAGCGAGGTATCTACGAGTCATGGATTCGACTAAAC GAGTATCCTTTCCTCGATCATCGTGATGACACCACTCCGCCAGACGTATCTGCCAACCGGGTCATGACAACCGTG GACGATATCAGCATCATTACTGCCACCGGTCATACTATTGCCTCGATCCGCAACCTCCTAGCTAACACTACATAT CGCGGATTCCCCATAGTATCAGACACGTCGAGTCCCGTCCTTCTAGGCTACATCACCCGCAATGAGATTTCTTTT GCGCTGAAATACTCGACCTCTGGTACAGCCCGCAACCTCTCCGACGAGACACAGGTCTTCTTTTCGCATCAACCT TTTGCAGACCCTAGTGATACCCTTGATCTACGACCTTGGATGGATCAGACACCGATGACATTGAACAGTAACATC ACCTTTTTGATTGTTTTGAAAATGTTCCAGCGCCTTGGCTTGCGTTATGTGTTATTTGCCAACAAGGGTATTCTA CAAGGACTACTGACCAAGAAAGATGTTTGGTCAGTGCTGAATGGCGTGGAAATCCGCCGAGAAGAAGCCCTTCGA GACGAAGAATACCAGGATTTCGAAAATCGTAATGAGGCTGAAGAGCAGGTTATCGAAATAAAATTGCGGCTTCGC CCCACCGCCTTTCTGACCCCACATATTTCTGTCGGCTTTTTAAAACTGACCGCTCTCATCTCTACCGGTACGGCT ACTGATCTTCCTACCCTTGAGGAAGCCATAACACCGGAAGATAAAATGATGATCGATCCTTTTGAGGTGCGCATG CGCTTCACTACACAGCTGCAGCACCTCAGTGCTGCTGTGACATCATCGCAGAAGGCTGCGCATTATGCGCTGAAG TACCGTGACCTCGATGAGGATCTTCACTCATGCATCCTGGAGCAGCTTGAGCGGAACAACATGAACAATCGTGCG AACATCATGTACTTTATTGAACACCTCTGCGAAATGGCCATCAAGGAAAACTACCTCCCATACGTGCGCATGATG CAACGAGACATTTTGCGCGTGGTCGACTCGGTCGTTCCTCCCGATGGCACTGGCGCAGCCAATGTCAAGCACGTC CGTCACGTCTTGAACGGTCTCCGAGCGAAGGAAGTCCTCAGCGCCGAAACCGTGGCCGAGATCGACGCGGCTCTG AAAGACCGCGATTCCCATCCCTCCCACCTGGATCTTGAACATGAGGAAGGCCCCGAGGGAGGCAGCAAGTCGAAG TCTGAGAAGCCCCAACTGCGCCTTGACAAGAAGCAGATCGAGCAGCGCATCGAGGAAGACCGGGAGCGCAACAAG CGTCAGCGCGAGAGCATGTGGGCCATGACTGGCAGTGATCAAGACGAATATAATCAGATGTGGGAGGAGCTCAGC CCCATTGGGGAGGACGACTTTATCCGGTCTCGTGAGGAGGCTTTAGAACGCGCCGAGTGTTTTCGCAAGCACGAG GAGTTTTATAAGAACCTCTACGGTATCAATGAGTAA
Transcript	>Pro_DTO377G3_2|g9666.t1 ATGAGTGGTCAGGGCTCAGGTGGCGAGGGCCAATCTGGGACGCAACTAGGATCTGATCAAGACATCCTTCAGCCT CAAGAAGTGAATCGGGAAGCCGAGAGGTTACATGAGCCGATCTCCTTCAAGCGAAAACAAAAACAACGATCACGG TTCAGTCTATCTAACCTTCTCTCCCCTCCCTCCGGCGGATCGGATACTGGCTTTGGCTCTCCGGCGCCGCAAGGT GGTCAGAACGGCGATGCATCGCCACTCGATCCTTACGCGCCGATAGGGCTCAATAGTGGTGCTGAAGCCTCAAAA GATGGCGCGCCATTGGACTGGTACGTGGAAGGCCCAGGACGACGTGTGGGCTACGACGACTTCACTGCTATCGAT TGGATCTACGAGTATACCAAGGAGCGGCAAAGGAAACGGCTTCTTTACTCGAGTGGACAGGGTCTATTGGGCCAT GCTCGTCGACTGCTTGACGCAAGCAATGTCTGGTTAGTGTTGATTGCGACAGGCATTGCTGTAGGAATAATCGCT GCTTCTATCGATATTGCAACGGATTGGCTAGGTGACCTGAAGTCCGGATATTGCAAAAATGGAAGTGGAGGTGGC AAGTTTTATCTCAACAAGAGCTTTTGCTGCTGGGGTCTCGATGATCAATCTAAGTGTTTAGACTGGACACCTTGG GGAAATGCATTAGGCGCAAAGTCCAGTGGAGGGGCATATACGGTTGGATATGTCTTTTATGTTTCATTTTCGGTT TTCTTTGCTGCATGTGCTTGCTTCTTGGTGCGAAATTATGCCGTTTATGCTAGACACAGTGGAATCCCCGAGATA AAAACGATCCTCGGTGGAACTGTCATCCGACATTTCATGGGACCATGGACACTTGCCATTAAATCACTGGGCCTG TGTCTTTCTGTGGCTTCCGGTCTATGGCTAGGTAAAGAGGGCCCACTTGTGCATGTTGCATGCTGTTGCGCGAAT ATCCTGATGAAACCTTTTGAAAGCCTGAAAGGCAATGAAGCACGCAAACGAGAGGTTCTTTCTGCGGCTGCTGCA GCAGGTATATCAGTCGCATTCGGGGCACCCATCGGAGGTGTTCTTTTTAGTTTGGAGCAACTTTCATATTATTTT CCCGACAAGACAATGTGGCAAAGCTTTGTCTGTGCCATGGTCGCAGCTGTCACTTTGCAAGCCTTGAACCCATTC CGGACAGGTAAAATTGTGCTGTATCAAGTCACCTACACTCGAGGCTGGCACCGCTTTGAGATCATCCCGTTCATT ATTCTTGGCATCATTGGCGGCCTCTACGGTGCATTCCTCATCCGCCTGAATACTAAAGTCACCAAATGGAGGCGA GCTCGGACTTCCTCTCGACCAATCATCGAAGTGGTTGTCGTGGCTCTCATTACAGCTTTGATCAACTATCCAAAT CACTTCATGCGGGCTCAGAACTCGGAGCTTGTCCAGTCGCTGTTCGCCGAGTGCAACAGTGTGACATATGATCGA TTTGGTCTCTGCGCCACGGGATCTGCCTCAATCGGCGTGGCAATCTACCTGGTCGTTGCTGCTTTACTTGCCTTT TTCTTGGCTTCCTTGACATTTGGACTTGAGATTCCTGCGGGTATCATCCTTCCTTCGGTCGCTATCGGTGCTCTT TACGGGCGTGCTCTGGGCATTATAGTTCGCTTGTGGCAAGAATCTTATCCGCAAGCATTCCTGTTTAGCAGGTGC GAGCCAGACATTCCATGTGTCACACCTGGCTTATACGCAATTATCGGGGCTGCTGCTGCTCTTGGTGGTGCTACT CGAATGACTTTGTCAATTGTCGTTATCATGTTCGAATTGACCGGCGCGCTGACCTACGTCATCCCGATCATGATT GCTGTGATGCTGTCCAAGTGGTGTGGTGACATCTTCGGGAAGCGAGGTATCTACGAGTCATGGATTCGACTAAAC GAGTATCCTTTCCTCGATCATCGTGATGACACCACTCCGCCAGACGTATCTGCCAACCGGGTCATGACAACCGTG GACGATATCAGCATCATTACTGCCACCGGTCATACTATTGCCTCGATCCGCAACCTCCTAGCTAACACTACATAT CGCGGATTCCCCATAGTATCAGACACGTCGAGTCCCGTCCTTCTAGGCTACATCACCCGCAATGAGATTTCTTTT GCGCTGAAATACTCGACCTCTGGTACAGCCCGCAACCTCTCCGACGAGACACAGGTCTTCTTTTCGCATCAACCT TTTGCAGACCCTAGTGATACCCTTGATCTACGACCTTGGATGGATCAGACACCGATGACATTGAACAGTAACATC ACCTTTTTGATTGTTTTGAAAATGTTCCAGCGCCTTGGCTTGCGTTATGTGTTATTTGCCAACAAGGGTATTCTA CAAGGACTACTGACCAAGAAAGATGTTTGGTCAGTGCTGAATGGCGTGGAAATCCGCCGAGAAGAAGCCCTTCGA GACGAAGAATACCAGGATTTCGAAAATCGTAATGAGGCTGAAGAGCAGGTTATCGAAATAAAATTGCGGCTTCGC CCCACCGCCTTTCTGACCCCACATATTTCTGTCGGCTTTTTAAAACTGACCGCTCTCATCTCTACCGGTACGGCT ACTGATCTTCCTACCCTTGAGGAAGCCATAACACCGGAAGATAAAATGATGATCGATCCTTTTGAGGTGCGCATG CGCTTCACTACACAGCTGCAGCACCTCAGTGCTGCTGTGACATCATCGCAGAAGGCTGCGCATTATGCGCTGAAG TACCGTGACCTCGATGAGGATCTTCACTCATGCATCCTGGAGCAGCTTGAGCGGAACAACATGAACAATCGTGCG AACATCATGTACTTTATTGAACACCTCTGCGAAATGGCCATCAAGGAAAACTACCTCCCATACGTGCGCATGATG CAACGAGACATTTTGCGCGTGGTCGACTCGGTCGTTCCTCCCGATGGCACTGGCGCAGCCAATGTCAAGCACGTC CGTCACGTCTTGAACGGTCTCCGAGCGAAGGAAGTCCTCAGCGCCGAAACCGTGGCCGAGATCGACGCGGCTCTG AAAGACCGCGATTCCCATCCCTCCCACCTGGATCTTGAACATGAGGAAGGCCCCGAGGGAGGCAGCAAGTCGAAG TCTGAGAAGCCCCAACTGCGCCTTGACAAGAAGCAGATCGAGCAGCGCATCGAGGAAGACCGGGAGCGCAACAAG CGTCAGCGCGAGAGCATGTGGGCCATGACTGGCAGTGATCAAGACGAATATAATCAGATGTGGGAGGAGCTCAGC CCCATTGGGGAGGACGACTTTATCCGGTCTCGTGAGGAGGCTTTAGAACGCGCCGAGTGTTTTCGCAAGCACGAG GAGTTTTATAAGAACCTCTACGGTATCAATGAGTAA
Gene	>Pro_DTO377G3_2|g9666.t1 ATGAGTGGTCAGGGCTCAGGTGGCGAGGGCCAATCTGGGACGCAACTAGGATCTGATCAAGACATCCTTCAGCCT CAAGAAGTGAATCGGGAAGCCGAGAGGTTACATGAGCCGTATGCCTTGGAGCCTCCACCTTTCGCTACGGCGCTG ATCAGGTTATTTATTTAGGATCTCCTTCAAGCGAAAACAAAAACAACGATCACGGTTCAGTCTATCTAACCTTCT CTCCCCTCCCTCCGGCGGATCGGATACTGGCTTTGGCTCTCCGGCGCCGCAAGGTGGTCAGAACGGCGATGCATC GCCACTCGATCCTTACGCGCCGATAGGGCTCAATAGTGGTGCTGAAGCCTCAAAAGATGGCGCGCCATTGGACTG GTACGTGGAAGGCCCAGGACGACGTGTGGGCTACGACGACTTCACTGCTATCGATTGGATCTACGAGTATACCAA GGAGCGGCAAAGGAAACGGCTTCTTTACTCGAGTGGACAGGGTCTATTGGGCCATGCTCGTCGACTGCTTGACGC AAGCAATGTCTGGTTAGTGTTGATTGCGACAGGCATTGCTGTAGGAATAATCGCTGCTTCTATCGATATTGCAAC GGATTGGCTAGGTGACCTGAAGTCCGGATATTGCAAAAATGGAAGTGGAGGTGGCAAGTTTTATCTCAACAAGAG CTTTTGCTGCTGGGGTCTCGATGGTAAGCCGATGGCGTCAAATCTCTACAAGTCTCACTACTGAATCTGGATTTG GTATAGATCAATCTAAGTGTTTAGACTGGACACCTTGGGGAAATGCATTAGGCGCAAAGTCCAGTGGAGGGGCAT ATACGGTTGGATATGTCTTTTATGTTTCATTTTCGGTAATGATGTCTCTGTCTCTTACCTTTAGGGCTCTATTGA CAGTACATATCTAGGTTTTCTTTGCTGCATGTGCTTGCTTCTTGGTGCGAAATTATGCCGTTTATGCTAGACACA GTGGAATCCCCGAGATAAAAACGATCCTCGGTGGAACTGTCATCCGACATTTCATGGGACCATGGACACTTGCCA TTAAATCACTGGGCCTGGTGAGTCAAGCTTCTTCTTGTTATAAGGCATTTTTGCTGACAACGATCAGTGTCTTTC TGTGGCTTCCGGTCTATGGCTAGGTAAAGAGGGCCCACTTGTGCATGTTGCATGCTGTTGCGCGAATATCCTGAT GAAACCTTTTGAAAGCCTGAAAGGCAATGAAGGTACGTGATTAATTCTATATTTCCCTCTGCGCATTTACTCATT TCACAGCACGCAAACGAGAGGTTCTTTCTGCGGCTGCTGCAGCAGGTATATCAGTCGCATTCGGGGCACCCATCG GAGGTGTTCTTTTTAGTTTGGAGGTATGAGCCATTTTCAATCTTGTCCTATATACTTTGCTGATTATTCTAGCAA CTTTCATATTATTTTCCCGACAAGACAATGTGGCAAAGCTTTGTCTGTGCCATGGTCGCAGCTGTCACTTTGCAA GCCTTGAACCCATTCCGGACAGGTAAAATTGTGCTGTATCAAGTCACCTACACTCGAGGCTGGCACCGCTTTGAG ATCATCCCGTTCATTATTCTTGGCATCATTGGCGGCCTCTACGGTGCATTCCTCATCCGCCTGAATACTAAAGTC ACCAAATGGAGGCGAGCTCGGACTTCCTCTCGACCAATCATCGAAGTGGTTGTCGTGGCTCTCATTACAGCTTTG ATCAACTATCCAAATCACTTCATGCGGGCTCAGAACTCGGAGCTTGTCCAGTCGCTGTTCGCCGAGTGCAACAGT GTGACATATGATCGATTTGGTCTCTGCGCCACGGGATCTGCCTCAATCGGCGTGGCAATCTACCTGGTCGTTGCT GCTTTACTTGCCTTTTTCTTGGCTTCCTTGACATTTGGACTTGAGATTCCTGCGGGTATCATCCTTCCTTCGGTC GCTATCGGTGCTCTTTACGGGCGTGCTCTGGGCATTATAGTTCGCTTGTGGCAAGAATCTTATCCGCAAGCATTC CTGTTTAGCAGGTGCGAGCCAGACATTCCATGTGTCACACCTGGCTTATACGCAATTATCGGGGCTGCTGCTGCT CTTGGTGGTGCTACTCGAATGACTTTGTCAATTGTCGTTATCATGTTCGAATTGACCGGCGCGCTGACCTACGTC ATCCCGATCATGATTGCTGTGATGCTGTCCAAGTGGTGTGGTGACATCTTCGGGAAGCGAGGTATCTACGAGTCA TGGATTCGACTAAACGAGTATCCTTTCCTCGATCATCGTGATGACACCACTCCGCCAGACGTATCTGCCAACCGG GTCATGACAACCGTGGACGATATCAGCATCATTACTGCCACCGGTCATACTATTGCCTCGATCCGCAACCTCCTA GCTAACACTACATATCGCGGATTCCCCATAGTATCAGACACGTCGAGTCCCGTCCTTCTAGGCTACATCACCCGC AATGAGATTTCTTTTGCGCTGAAATACTCGACCTCTGGTACAGCCCGCAACCTCTCCGACGAGACACAGGTCTTC TTTTCGCATCAACCTTTTGCAGACCCTAGTGATACCCTTGATCTACGACCTTGGATGGATCAGACACCGATGACA TTGAACAGTAACATCACCTTTTTGATTGTTTTGAAAATGTTCCAGCGCCTTGGCTTGCGTTATGTGTTATTTGCC AACAAGGGTATTCTACAAGGACTACTGACCAAGAAAGATGTTTGGTCAGTGCTGAATGGCGTGGAAATCCGCCGA GAAGAAGCCCTTCGAGACGAAGAATACCAGGATTTCGAAAATCGTAATGAGGCTGAAGAGGTTGGTTTGCTTGAT GGGAATGATACATCTAGTCTTGGTAGTTCGCTGAGGCGGGATTCCCTTTGATGATATTTGCTACCATATTGCTCG GTGTATCTTGATTTTGTTACAATGTTCACGAATATTCACTTCAAATGATGCCAGAGAAGTCGCTACGTTATGTAT GGAGTACGTAGCAGGTTATCGAAATAAAATTGCGGCTTCGCCCCACCGCCTTTCTGACCCCACATATTTCTGTCG GCTTTTTAAAACTGACCGCTCTCATCTCTACCGGTACGGCTACTGATCTTCCTACCCTTGAGGAAGCCATAACAC CGGAAGATAAAATGATGATCGATCCTTTTGAGGTGCGCATGCGCTTCACTACACAGCTGCAGCACCTCAGTGCTG CTGTGACATCATCGCAGAAGGCTGCGCATTATGCGCTGAAGTACCGTGACCTCGATGAGGATCTTCACTCATGCA TCCTGGAGCAGCTTGAGCGGGTAAGAGCTCCGATTTCATTGTGTGTTGATCTATTCTGACTTTACATGTGGCAGA ACAACATGAACAATCGTGCGAACATCATGTACTTTATTGAACACCTCTGCGAAATGGCCATCAAGGAAAACTACC TCCCATACGTGCGCATGATGCAACGAGACATTTTGCGCGTGGTCGACTCGGTCGTTCCTCCCGATGGCACTGGCG CAGCCAATGTCAAGCACGTCCGTCACGTCTTGAACGGTCTCCGAGCGAAGGAAGTCCTCAGCGCCGAAACCGTGG CCGAGATCGACGCGGCTCTGAAAGACCGCGATTCCCATCCCTCCCACCTGGATCTTGAACATGAGGAAGGCCCCG AGGGAGGCAGCAAGTCGAAGTCTGAGAAGCCCCAACTGCGCCTTGACAAGAAGCAGATCGAGCAGCGCATCGAGG AAGACCGGGAGCGCAACAAGCGTCAGCGCGAGAGCATGTGGGCCATGACTGGCAGTGATCAAGACGAATATAATC AGATGTGGGAGGAGCTCAGCCCCATTGGGGAGGACGACTTTATCCGGTCTCGTGAGGAGGCTTTAGAACGCGCCG AGTGTTTTCGCAAGCACGAGGAGTTTTATAAGAACCTCTACGGTATCAATGAGTAA