Fungal Genomics

Agaricus bisporus var bisporus H39 Agaricus bisporus var bisporus H97 Agaricus bisporus var burnettii H119p4 Aspergillus niger CBS 112.32 Aspergillus niger CBS 113.50 Aspergillus niger CBS 115988 Aspergillus niger CBS 115989 Aspergillus niger CBS 118.52 Aspergillus niger CBS 124.48 Aspergillus niger CBS 131.52 Aspergillus niger CBS 133816 Aspergillus niger CBS 147320 Aspergillus niger CBS 147321 Aspergillus niger CBS 147322 Aspergillus niger CBS 147323 Aspergillus niger CBS 147324 Aspergillus niger CBS 147343 Aspergillus niger CBS 147344 Aspergillus niger CBS 147345 Aspergillus niger CBS 147346 Aspergillus niger CBS 147347 Aspergillus niger CBS 147352 Aspergillus niger CBS 147353 Aspergillus niger CBS 147371 Aspergillus niger CBS 147482 Aspergillus niger CBS 630.78 Aspergillus niger CBS 769.97 Niveomyces coronatus CBS 149186 Ophiocordyceps australis 1348a (Ghana) Ophiocordyceps australis map64 (Brazil) Ophiocordyceps camponoti-floridani Ophiocordyceps camponoti-rufipedis Ophiocordyceps kimflemingae Ophiocordyceps subramaniannii Penicillium roqueforti DTO002I6 Penicillium roqueforti DTO003C3 Penicillium roqueforti DTO003H1 (CBS 147308) Penicillium roqueforti DTO006G1 Penicillium roqueforti DTO006G7 Penicillium roqueforti DTO012A1 Penicillium roqueforti DTO012A2 (CBS 147309) Penicillium roqueforti DTO012A6 (CBS 147310) Penicillium roqueforti DTO012A7 Penicillium roqueforti DTO012A8 Penicillium roqueforti DTO012A9 Penicillium roqueforti DTO013E5 Penicillium roqueforti DTO013F2 Penicillium roqueforti DTO013F5 (CBS 147311) Penicillium roqueforti DTO027I6 Penicillium roqueforti DTO032C6 Penicillium roqueforti DTO039G3 Penicillium roqueforti DTO046C5 Penicillium roqueforti DTO070G2 (CBS 147317) Penicillium roqueforti DTO081F9 (CBS 147318) Penicillium roqueforti DTO101D6 (CBS 147325) Penicillium roqueforti DTO102I9 (CBS 147326) Penicillium roqueforti DTO126G2 (CBS 147330) Penicillium roqueforti DTO127F7 (CBS 147331) Penicillium roqueforti DTO127F9 (CBS 147332) Penicillium roqueforti DTO130C1 (CBS 147333) Penicillium roqueforti DTO163C3 (CBS 147337) Penicillium roqueforti DTO163F5 (CBS 147338) Penicillium roqueforti DTO163G4 (CBS 147339) Penicillium roqueforti DTO265D5 (CBS 147372) Penicillium roqueforti DTO369A1 (CBS 147354) Penicillium roqueforti DTO375B1 (CBS 147355) Penicillium roqueforti DTO377G2 (LCP 96.3914a) Penicillium roqueforti LCP96 04111 Rhodonia placenta FPRL280 Torrubiellomyces zombiae CBS 149187

General Properties

Protein ID	Pro_DTO377G3_2|g9473.t1
Gene name
Location	scaffold_48:97744..101533
Strand	-
Gene length (bp)	3789
Transcript length (bp)	3582
Coding sequence length (bp)	3582
Protein length (aa)	1194

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PFAM Domains

PFAM Domain ID	Short name	Long name	E-value	Start	End
PF02518	HATPase_c	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	3.1E-20	696	812
PF00072	Response_reg	Response regulator receiver domain	5.9E-19	1064	1179
PF00512	HisKA	His Kinase A (phospho-acceptor) domain	4.8E-13	527	589

GO

GO Term	Description	Terminal node
GO:0007165	signal transduction	Yes
GO:0000160	phosphorelay signal transduction system	Yes
GO:0000155	phosphorelay sensor kinase activity	Yes
GO:0003824	catalytic activity	No
GO:0140299	small molecule sensor activity	No
GO:0140096	catalytic activity, acting on a protein	No
GO:0004672	protein kinase activity	No
GO:0016772	transferase activity, transferring phosphorus-containing groups	No
GO:0008150	biological_process	No
GO:0016740	transferase activity	No
GO:0004673	protein histidine kinase activity	No
GO:0050789	regulation of biological process	No
GO:0016301	kinase activity	No
GO:0065007	biological regulation	No
GO:0003674	molecular_function	No
GO:0035556	intracellular signal transduction	No
GO:0016775	phosphotransferase activity, nitrogenous group as acceptor	No
GO:0050794	regulation of cellular process	No
GO:0009987	cellular process	No
GO:0016773	phosphotransferase activity, alcohol group as acceptor	No

SignalP

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SignalP signal predicted	Location (based on Ymax)	D score (significance: > 0.45)
No	1 - 44	0.45

Transmembrane Domains

(None)

Transcription Factor Class

(None)

Expression data

Analysis 1: Genome-wide gene expression in conidia of Penicillium roqueforti during growth at various temperatures and for various amounts of time. Published in Punt et al., 2020.

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Sequences

Type of sequence	Sequence
Locus	Download genbank file of locus The gene with 5 kb flanks (if sufficient flanking sequence is available). For use in cloning design programs. NOTE: features (genes or exons) that are only partially contained within the sequence are completely excluded.
Protein	>Pro_DTO377G3_2|g9473.t1 MENPTQETIHAHEADRQAREVYRYFQPANPAALNAAWLPRSAASEFETESSSLSSPNTTLTSFAQQAAIRLNAQR AFITILNHDSQFIIAEATKTTNIGNSKLYTAEGDGLFAGTSTLPNAWNICWETVAVASETDDGTFPVLVVNDLTQ EERFRQLPFVKGEPHSRFYAGTPLITDSGTNLGCLFVLDTQPRDGLSDDGKDALGTVAAMVMDYLHVSRRAVEGH RASRLSQSLRSFVDGKSSFADNDHMSRSQSSNSSSSSRGSAHSRTSRSASSENSDAHSQIGDPRSSSAVSNENSD VEPFANAAASFRSSRRGGSSSSISSDSNDRIFQRAANLLRQGLDLHGAGGVIFLKVSDVSPDCFSSGDSTSVNPK TSASVLSISTRIDPFSSQDNSLSPCAAANMDKDFLYRLTRRYPKGRLWSFHRDGSLSTSDEEHSTTATQKQRIKH KASETFKLNSYFPDACQVMFVPLWDATNSEWFAGCFCWTPQPTRVFSRAVDLTSIFGFASSIMTEYSRVESVIAD RQKGDFISSISHELRSPLHGVLAATEFLGDTQLDDFQESLIETINACGRTLLDTMNQVLDFSKIMSLERRKRRSR RRKDFSKLKFTEQNPARMDQFVATNIATLTEDVVDSVCLGHSHMKQSASLANHSKLISRSLPTQLVREDEEVTSS PDIEIVINITNNDWVYKVQPGSLRRLIMNLLGNALKYTEKGLVSICVEATQCPKGRSRRQNPEDMVTLTISDTGK GISSEYLRTRLYTPFSQEDTLSVGTGLGLSIVRGIVDILDGSIDFQSRVGEGTVVQVSIPLERLTEEEYSSSIDV DCAGKSPIPSTQLSCMGLTKSCAAFWGMDSSLIGNQFWSSIAQYLMDWYGIKVVPWSANEYIDFVFVNETYLSDE KVRQSLTGSPNLLVFCNEWDNSSDPRKKWSHLAGAFSVLRRPCGPQRLARGILGCLNSTPASPRSHLPTAGSESA FPERLKLARPPPMAETSTHSSLGHPEKPAAESLDFTPNLHSHVGSVRRDNPVLLSGTEISGRTTSSTLSNSSSLN PTGTPNESQSGPRVLLVDDNDINLRLMTTFMNKRKVPLLEIAQNGREAVECVERMSKGYDLIFMDISMPIMDGNE ATRIIRTMEKARDGCVRAKIIAFTGLSSSHAEIKALDSGVDLFLTKPVSLKEVSRLLNEWETEQPNWK*
Coding	>Pro_DTO377G3_2|g9473.t1 ATGGAAAACCCAACACAAGAGACTATCCATGCCCACGAAGCAGATCGTCAAGCTCGCGAGGTCTATCGGTATTTC CAACCAGCCAACCCCGCCGCGCTTAACGCAGCATGGCTTCCTCGCTCTGCTGCCTCCGAATTTGAAACCGAATCT AGCTCCCTGTCTAGTCCGAATACGACATTGACCTCGTTCGCACAGCAGGCAGCCATACGCCTCAACGCACAGCGT GCCTTTATCACTATATTGAATCACGATTCACAGTTCATCATAGCCGAAGCTACGAAGACTACAAATATTGGAAAC TCGAAGTTGTACACGGCGGAGGGAGATGGGCTTTTTGCCGGAACATCGACTTTGCCAAACGCTTGGAACATATGT TGGGAAACAGTCGCAGTTGCCTCAGAAACGGATGATGGAACCTTCCCCGTACTGGTCGTCAACGATCTTACACAG GAGGAGCGCTTCAGACAATTGCCATTCGTCAAAGGAGAGCCACACTCTCGCTTCTATGCTGGAACACCCTTGATC ACCGACAGCGGTACTAATCTAGGATGCTTGTTTGTGTTGGATACTCAACCCCGTGACGGCCTGTCTGACGATGGG AAGGACGCACTAGGAACAGTGGCAGCGATGGTCATGGACTATCTACACGTCAGCCGACGGGCCGTCGAAGGGCAC CGCGCCTCGCGGCTGTCGCAGAGTCTGCGTTCTTTCGTTGATGGCAAATCCAGTTTCGCCGACAATGACCACATG TCTCGCTCCCAGAGCTCAAACTCTAGTTCTTCCTCGCGGGGATCGGCGCACTCTCGGACGAGCCGATCTGCCAGC TCTGAAAATAGCGATGCGCACTCTCAAATTGGTGACCCTCGGTCTTCAAGCGCAGTTTCCAACGAGAATTCAGAC GTAGAGCCTTTTGCAAACGCAGCGGCTTCATTCAGAAGCTCACGTCGAGGCGGCAGCAGTTCATCGATATCCTCG GATAGCAATGACCGGATTTTTCAACGAGCTGCAAATCTTTTAAGGCAAGGTCTAGACTTGCACGGTGCTGGCGGC GTGATCTTTCTCAAGGTCAGCGACGTCTCGCCAGATTGTTTCTCTAGCGGTGACTCTACTTCTGTCAATCCGAAA ACTTCTGCGTCTGTTCTTTCCATTTCCACCAGGATTGATCCATTTTCGTCTCAGGATAACTCTTTGTCGCCATGC GCGGCTGCCAATATGGACAAAGATTTTCTATATCGATTAACTCGTCGCTATCCCAAGGGAAGACTCTGGTCATTT CACAGAGATGGGTCTTTATCCACCTCGGACGAAGAGCATTCCACTACCGCAACTCAGAAACAACGGATCAAGCAC AAGGCCTCAGAAACCTTTAAACTCAATTCGTATTTTCCTGATGCGTGCCAAGTCATGTTTGTTCCCTTATGGGAT GCCACCAATTCTGAGTGGTTTGCTGGATGCTTCTGTTGGACACCTCAACCGACAAGAGTTTTCAGTCGGGCTGTT GATTTGACCTCAATATTTGGCTTCGCATCGTCCATAATGACCGAATACAGCCGTGTTGAATCGGTCATCGCAGAC CGCCAGAAGGGGGACTTCATAAGTAGCATCTCACACGAGCTTCGCAGCCCCCTGCATGGTGTCTTGGCTGCAACC GAATTCCTGGGAGACACTCAGCTGGATGATTTCCAGGAATCTCTTATCGAGACTATCAATGCATGTGGGCGAACA CTATTGGATACGATGAACCAAGTGCTAGACTTTAGCAAAATCATGTCATTGGAAAGGCGGAAGAGAAGGTCCAGG CGCCGAAAGGATTTCTCAAAGCTAAAGTTTACCGAGCAAAACCCAGCGCGCATGGATCAATTCGTGGCGACTAAT ATTGCCACATTGACAGAGGACGTTGTTGATAGTGTGTGCTTGGGACATTCCCATATGAAACAGTCTGCATCGCTA GCCAATCATTCCAAACTTATTTCACGGAGTTTGCCTACCCAACTGGTAAGAGAGGACGAGGAAGTCACCTCCAGT CCAGATATCGAGATTGTCATTAATATTACCAACAACGACTGGGTATATAAAGTTCAGCCAGGATCGCTGCGGCGC CTCATCATGAACCTTCTCGGTAATGCTCTCAAGTATACCGAGAAGGGCCTGGTTTCAATTTGCGTGGAGGCCACT CAGTGTCCGAAAGGTCGTTCGCGGCGTCAGAATCCCGAGGATATGGTAACCTTGACTATATCCGACACAGGGAAA GGCATTTCGAGCGAATACCTACGGACTCGTTTATATACTCCATTTTCGCAGGAGGATACGCTGTCAGTGGGTACC GGCCTTGGTCTGTCAATTGTTCGCGGCATTGTGGATATACTTGACGGAAGTATCGACTTTCAAAGCCGAGTAGGC GAAGGCACTGTGGTCCAAGTCTCGATTCCTCTTGAGCGTCTAACCGAGGAAGAATATTCATCATCAATTGATGTG GATTGCGCAGGAAAGTCGCCTATCCCGTCCACACAACTTTCTTGTATGGGGTTAACGAAGAGTTGTGCTGCCTTT TGGGGAATGGACTCCTCCCTTATCGGAAATCAGTTCTGGTCTTCGATCGCTCAGTATTTGATGGATTGGTATGGC ATCAAGGTCGTGCCTTGGTCTGCCAATGAATATATTGATTTTGTATTTGTTAACGAGACCTACTTGTCCGACGAA AAGGTACGGCAATCACTTACTGGATCACCAAATTTGCTCGTCTTTTGCAATGAATGGGACAACTCCAGTGACCCT AGGAAAAAGTGGTCACACCTTGCTGGGGCTTTTAGCGTTCTACGTCGACCTTGCGGTCCACAAAGACTCGCAAGA GGTATCTTGGGCTGTCTTAATTCGACACCGGCGTCTCCTAGATCGCATCTACCTACTGCCGGATCAGAATCTGCC TTTCCGGAACGACTCAAGCTTGCACGCCCGCCTCCAATGGCCGAGACTTCCACACATTCGTCACTTGGTCATCCA GAGAAACCAGCTGCTGAGTCATTGGATTTCACACCAAACCTACACTCACATGTTGGCTCCGTCAGGCGTGATAAT CCCGTGCTACTTTCAGGGACAGAAATATCCGGTCGTACCACGTCGTCTACTCTATCGAATTCTTCCAGCCTAAAT CCTACTGGTACGCCAAATGAGAGCCAGAGCGGACCTCGGGTCTTGCTGGTAGATGATAACGATATCAATCTCCGC CTGATGACGACTTTTATGAACAAACGAAAGGTCCCGCTTTTGGAGATAGCACAAAACGGCAGAGAAGCAGTAGAG TGCGTCGAGAGGATGTCGAAGGGGTATGACCTCATTTTCATGGATATTTCCATGCCCATCATGGACGGAAATGAA GCAACGCGCATCATTCGCACGATGGAAAAAGCACGGGATGGGTGCGTTCGGGCAAAAATAATTGCTTTTACTGGC CTTAGTAGCTCCCATGCGGAGATCAAGGCGCTAGACTCAGGAGTGGACCTATTTCTTACGAAACCTGTCTCGTTG AAGGAAGTATCGCGATTGCTTAATGAGTGGGAAACTGAACAACCAAATTGGAAATAA
Transcript	>Pro_DTO377G3_2|g9473.t1 ATGGAAAACCCAACACAAGAGACTATCCATGCCCACGAAGCAGATCGTCAAGCTCGCGAGGTCTATCGGTATTTC CAACCAGCCAACCCCGCCGCGCTTAACGCAGCATGGCTTCCTCGCTCTGCTGCCTCCGAATTTGAAACCGAATCT AGCTCCCTGTCTAGTCCGAATACGACATTGACCTCGTTCGCACAGCAGGCAGCCATACGCCTCAACGCACAGCGT GCCTTTATCACTATATTGAATCACGATTCACAGTTCATCATAGCCGAAGCTACGAAGACTACAAATATTGGAAAC TCGAAGTTGTACACGGCGGAGGGAGATGGGCTTTTTGCCGGAACATCGACTTTGCCAAACGCTTGGAACATATGT TGGGAAACAGTCGCAGTTGCCTCAGAAACGGATGATGGAACCTTCCCCGTACTGGTCGTCAACGATCTTACACAG GAGGAGCGCTTCAGACAATTGCCATTCGTCAAAGGAGAGCCACACTCTCGCTTCTATGCTGGAACACCCTTGATC ACCGACAGCGGTACTAATCTAGGATGCTTGTTTGTGTTGGATACTCAACCCCGTGACGGCCTGTCTGACGATGGG AAGGACGCACTAGGAACAGTGGCAGCGATGGTCATGGACTATCTACACGTCAGCCGACGGGCCGTCGAAGGGCAC CGCGCCTCGCGGCTGTCGCAGAGTCTGCGTTCTTTCGTTGATGGCAAATCCAGTTTCGCCGACAATGACCACATG TCTCGCTCCCAGAGCTCAAACTCTAGTTCTTCCTCGCGGGGATCGGCGCACTCTCGGACGAGCCGATCTGCCAGC TCTGAAAATAGCGATGCGCACTCTCAAATTGGTGACCCTCGGTCTTCAAGCGCAGTTTCCAACGAGAATTCAGAC GTAGAGCCTTTTGCAAACGCAGCGGCTTCATTCAGAAGCTCACGTCGAGGCGGCAGCAGTTCATCGATATCCTCG GATAGCAATGACCGGATTTTTCAACGAGCTGCAAATCTTTTAAGGCAAGGTCTAGACTTGCACGGTGCTGGCGGC GTGATCTTTCTCAAGGTCAGCGACGTCTCGCCAGATTGTTTCTCTAGCGGTGACTCTACTTCTGTCAATCCGAAA ACTTCTGCGTCTGTTCTTTCCATTTCCACCAGGATTGATCCATTTTCGTCTCAGGATAACTCTTTGTCGCCATGC GCGGCTGCCAATATGGACAAAGATTTTCTATATCGATTAACTCGTCGCTATCCCAAGGGAAGACTCTGGTCATTT CACAGAGATGGGTCTTTATCCACCTCGGACGAAGAGCATTCCACTACCGCAACTCAGAAACAACGGATCAAGCAC AAGGCCTCAGAAACCTTTAAACTCAATTCGTATTTTCCTGATGCGTGCCAAGTCATGTTTGTTCCCTTATGGGAT GCCACCAATTCTGAGTGGTTTGCTGGATGCTTCTGTTGGACACCTCAACCGACAAGAGTTTTCAGTCGGGCTGTT GATTTGACCTCAATATTTGGCTTCGCATCGTCCATAATGACCGAATACAGCCGTGTTGAATCGGTCATCGCAGAC CGCCAGAAGGGGGACTTCATAAGTAGCATCTCACACGAGCTTCGCAGCCCCCTGCATGGTGTCTTGGCTGCAACC GAATTCCTGGGAGACACTCAGCTGGATGATTTCCAGGAATCTCTTATCGAGACTATCAATGCATGTGGGCGAACA CTATTGGATACGATGAACCAAGTGCTAGACTTTAGCAAAATCATGTCATTGGAAAGGCGGAAGAGAAGGTCCAGG CGCCGAAAGGATTTCTCAAAGCTAAAGTTTACCGAGCAAAACCCAGCGCGCATGGATCAATTCGTGGCGACTAAT ATTGCCACATTGACAGAGGACGTTGTTGATAGTGTGTGCTTGGGACATTCCCATATGAAACAGTCTGCATCGCTA GCCAATCATTCCAAACTTATTTCACGGAGTTTGCCTACCCAACTGGTAAGAGAGGACGAGGAAGTCACCTCCAGT CCAGATATCGAGATTGTCATTAATATTACCAACAACGACTGGGTATATAAAGTTCAGCCAGGATCGCTGCGGCGC CTCATCATGAACCTTCTCGGTAATGCTCTCAAGTATACCGAGAAGGGCCTGGTTTCAATTTGCGTGGAGGCCACT CAGTGTCCGAAAGGTCGTTCGCGGCGTCAGAATCCCGAGGATATGGTAACCTTGACTATATCCGACACAGGGAAA GGCATTTCGAGCGAATACCTACGGACTCGTTTATATACTCCATTTTCGCAGGAGGATACGCTGTCAGTGGGTACC GGCCTTGGTCTGTCAATTGTTCGCGGCATTGTGGATATACTTGACGGAAGTATCGACTTTCAAAGCCGAGTAGGC GAAGGCACTGTGGTCCAAGTCTCGATTCCTCTTGAGCGTCTAACCGAGGAAGAATATTCATCATCAATTGATGTG GATTGCGCAGGAAAGTCGCCTATCCCGTCCACACAACTTTCTTGTATGGGGTTAACGAAGAGTTGTGCTGCCTTT TGGGGAATGGACTCCTCCCTTATCGGAAATCAGTTCTGGTCTTCGATCGCTCAGTATTTGATGGATTGGTATGGC ATCAAGGTCGTGCCTTGGTCTGCCAATGAATATATTGATTTTGTATTTGTTAACGAGACCTACTTGTCCGACGAA AAGGTACGGCAATCACTTACTGGATCACCAAATTTGCTCGTCTTTTGCAATGAATGGGACAACTCCAGTGACCCT AGGAAAAAGTGGTCACACCTTGCTGGGGCTTTTAGCGTTCTACGTCGACCTTGCGGTCCACAAAGACTCGCAAGA GGTATCTTGGGCTGTCTTAATTCGACACCGGCGTCTCCTAGATCGCATCTACCTACTGCCGGATCAGAATCTGCC TTTCCGGAACGACTCAAGCTTGCACGCCCGCCTCCAATGGCCGAGACTTCCACACATTCGTCACTTGGTCATCCA GAGAAACCAGCTGCTGAGTCATTGGATTTCACACCAAACCTACACTCACATGTTGGCTCCGTCAGGCGTGATAAT CCCGTGCTACTTTCAGGGACAGAAATATCCGGTCGTACCACGTCGTCTACTCTATCGAATTCTTCCAGCCTAAAT CCTACTGGTACGCCAAATGAGAGCCAGAGCGGACCTCGGGTCTTGCTGGTAGATGATAACGATATCAATCTCCGC CTGATGACGACTTTTATGAACAAACGAAAGGTCCCGCTTTTGGAGATAGCACAAAACGGCAGAGAAGCAGTAGAG TGCGTCGAGAGGATGTCGAAGGGGTATGACCTCATTTTCATGGATATTTCCATGCCCATCATGGACGGAAATGAA GCAACGCGCATCATTCGCACGATGGAAAAAGCACGGGATGGGTGCGTTCGGGCAAAAATAATTGCTTTTACTGGC CTTAGTAGCTCCCATGCGGAGATCAAGGCGCTAGACTCAGGAGTGGACCTATTTCTTACGAAACCTGTCTCGTTG AAGGAAGTATCGCGATTGCTTAATGAGTGGGAAACTGAACAACCAAATTGGAAATAA
Gene	>Pro_DTO377G3_2|g9473.t1 ATGGAAAACCCAACACAAGAGACTATCCATGCCCACGAAGCAGATCGTCAAGCTCGCGAGGTCTATCGGTATTTC CAACCAGCCAACCCCGCCGCGCTTAACGCAGCATGGCTTCCTCGCTCTGCTGCCTCCGAATTTGAAACCGAATCT AGCTCCCTGTCTAGTCCGAATACGACATTGACCTCGTTCGCACAGCAGGCAGCCATACGCCTCAACGCACAGCGT GCCTTTATCACGTAATTCTTCCATTATCTTTCAAATCTCCAAGACGGATCTACCTACATTTTCGTTGACCTTGGG CTGATTTTTGGCCATCAAGTATATTGAATCACGATTCACAGTTCATCATAGCCGAAGCTACGAAGACTACAAATA TTGGAAACTCGAAGTTGTACACGGCGGAGGGAGATGGGCTTTTTGCCGGAACATCGACTTTGCCAAACGCTTGGA ACATATGTTGGGTAAGGCCAATCAATCTGTGATTTTGCCACGCACCCGTCATTGTTCTGGATTTGATCTTTTATC TGAACAGGAAACAGTCGCAGTTGCCTCAGAAACGGATGATGGAACCTTCCCCGTACTGGTCGTCAACGATCTTAC ACAGGAGGAGCGCTTCAGACAATTGCCATTCGTCAAAGGAGAGCCACACTCTCGCTTCTATGCTGGAACACCCTT GATCACCGACAGCGGTACTAATCTAGGATGCTTGTTTGTGTTGGATACTCAACCCCGTGACGGCCTGTCTGACGA TGGGAAGGACGCACTAGGAACAGTGGCAGCGATGGTCATGGACTATCTACACGTCAGCCGACGGGCCGTCGAAGG GCACCGCGCCTCGCGGCTGTCGCAGAGTCTGCGTTCTTTCGTTGATGGCAAATCCAGTTTCGCCGACAATGACCA CATGTCTCGCTCCCAGAGCTCAAACTCTAGTTCTTCCTCGCGGGGATCGGCGCACTCTCGGACGAGCCGATCTGC CAGCTCTGAAAATAGCGATGCGCACTCTCAAATTGGTGACCCTCGGTCTTCAAGCGCAGTTTCCAACGAGAATTC AGACGTAGAGCCTTTTGCAAACGCAGCGGCTTCATTCAGAAGCTCACGTCGAGGCGGCAGCAGTTCATCGATATC CTCGGATAGCAATGACCGGATTTTTCAACGAGCTGCAAATCTTTTAAGGCAAGGTCTAGACTTGCACGGTGCTGG CGGCGTGATCTTTCTCAAGGTCAGCGACGTCTCGCCAGATTGTTTCTCTAGCGGTGACTCTACTTCTGTCAATCC GAAAACTTCTGCGTCTGTTCTTTCCATTTCCACCAGGATTGATCCATTTTCGTCTCAGGATAACTCTTTGTCGCC ATGCGCGGCTGCCAATATGGACAAAGATTTTCTATATCGATTAACTCGTCGCTATCCCAAGGGAAGACTCTGGTC ATTTCACAGAGATGGGTCTTTATCCACCTCGGACGAAGAGCATTCCACTACCGCAACTCAGAAACAACGGATCAA GCACAAGGCCTCAGAAACCTTTAAACTCAATTCGTATTTTCCTGATGCGTGCCAAGTCATGTTTGTTCCCTTATG GGATGCCACCAATTCTGAGTGGTTTGCTGGATGCTTCTGTTGGACACCTCAACCGACAAGAGTTTTCAGTCGGGC TGTTGATTTGACCTCAATATTTGGCTTCGCATCGTCCATAATGACCGAATACAGCCGTGTTGAATCGGTCATCGC AGACCGCCAGAAGGGGGACTTCATAAGTAGCATCTCGTGAGTCATCATTTGCTCTCTAAAATGCAGCTGGTACTG ACTCTGTTTCTTAGACACGAGCTTCGCAGCCCCCTGCATGGTGTCTTGGCTGCAACCGAATTCCTGGGAGACACT CAGCTGGATGATTTCCAGGAATCTCTTATCGAGACTATCAATGCATGTGGGCGAACACTATTGGATACGATGAAC CAAGTGCTAGACTTTAGCAAAATCATGTCATTGGAAAGGCGGAAGAGAAGGTCCAGGCGCCGAAAGGATTTCTCA AAGCTAAAGTTTACCGAGCAAAACCCAGCGCGCATGGATCAATTCGTGGCGACTAATATTGCCACATTGACAGAG GACGTTGTTGATAGTGTGTGCTTGGGACATTCCCATATGAAACAGTCTGCATCGCTAGCCAATCATTCCAAACTT ATTTCACGGAGTTTGCCTACCCAACTGGTAAGAGAGGACGAGGAAGTCACCTCCAGTCCAGATATCGAGATTGTC ATTAATATTACCAACAACGACTGGGTATATAAAGTTCAGCCAGGATCGCTGCGGCGCCTCATCATGAACCTTCTC GGTAATGCTCTCAAGTATACCGAGAAGGGCCTGGTTTCAATTTGCGTGGAGGCCACTCAGTGTCCGAAAGGTCGT TCGCGGCGTCAGAATCCCGAGGATATGGTAACCTTGACTATATCCGACACAGGGAAAGGCATTTCGAGCGAATAC CTACGGACTCGTTTATATACTCCATTTTCGCAGGAGGATACGCTGTCAGTGGGTACCGGCCTTGGTCTGTCAATT GTTCGCGGCATTGTGGATATACTTGACGGAAGTATCGACTTTCAAAGCCGAGTAGGCGAAGGCACTGTGGTCCAA GTCTCGATTCCTCTTGAGCGTCTAACCGAGGAAGAATATTCATCATCAATTGATGTGGATTGCGCAGGAAAGTCG CCTATCCCGTCCACACAACTTTCTTGTATGGGGTTAACGAAGAGTTGTGCTGCCTTTTGGGGAATGGACTCCTCC CTTATCGGAAATCAGTTCTGGTCTTCGATCGCTCAGTATTTGATGGATTGGTATGGCATCAAGGTCGTGCCTTGG TCTGCCAATGAATATATTGATTTTGTATTTGTTAACGAGACCTACTTGTCCGACGAAAAGGTACGGCAATCACTT ACTGGATCACCAAATTTGCTCGTCTTTTGCAATGAATGGGACAACTCCAGTGACCCTAGGAAAAAGTGGTCACAC CTTGCTGGGGCTTTTAGCGTTCTACGTCGACCTTGCGGTCCACAAAGACTCGCAAGAGGTATCTTGGGCTGTCTT AATTCGACACCGGCGTCTCCTAGATCGCATCTACCTACTGCCGGATCAGAATCTGCCTTTCCGGAACGACTCAAG CTTGCACGCCCGCCTCCAATGGCCGAGACTTCCACACATTCGTCACTTGGTCATCCAGAGAAACCAGCTGCTGAG TCATTGGATTTCACACCAAACCTACACTCACATGTTGGCTCCGTCAGGCGTGATAATCCCGTGCTACTTTCAGGG ACAGAAATATCCGGTCGTACCACGTCGTCTACTCTATCGAATTCTTCCAGCCTAAATCCTACTGGTACGCCAAAT GAGAGCCAGAGCGGACCTCGGGTCTTGCTGGTAGATGATAACGATATCAATCTCCGCCTGATGACGACTTTTATG AACAAACGAAAGGTCCCGCTTTTGGAGATAGCACAAAACGGCAGAGAAGCAGTAGAGTGCGTCGAGAGGATGTCG AAGGGGTATGACCTCATTTTCATGGATATTTCCATGCCCATCATGGACGGAAATGAAGCAACGCGCATCATTCGC ACGATGGAAAAAGCACGGGATGGGTGCGTTCGGGCAAAAATAATTGCTTTTACTGGCCTTAGTAGCTCCCATGCG GAGATCAAGGCGCTAGACTCAGGAGTGGACCTATTTCTTACGAAACCTGTCTCGTTGAAGGAAGTATCGCGATTG CTTAATGAGTGGGAAACTGAACAACCAAATTGGAAATAA