Fungal Genomics

Agaricus bisporus var bisporus H39 Agaricus bisporus var bisporus H97 Agaricus bisporus var burnettii H119p4 Aspergillus niger CBS 112.32 Aspergillus niger CBS 113.50 Aspergillus niger CBS 115988 Aspergillus niger CBS 115989 Aspergillus niger CBS 118.52 Aspergillus niger CBS 124.48 Aspergillus niger CBS 131.52 Aspergillus niger CBS 133816 Aspergillus niger CBS 147320 Aspergillus niger CBS 147321 Aspergillus niger CBS 147322 Aspergillus niger CBS 147323 Aspergillus niger CBS 147324 Aspergillus niger CBS 147343 Aspergillus niger CBS 147344 Aspergillus niger CBS 147345 Aspergillus niger CBS 147346 Aspergillus niger CBS 147347 Aspergillus niger CBS 147352 Aspergillus niger CBS 147353 Aspergillus niger CBS 147371 Aspergillus niger CBS 147482 Aspergillus niger CBS 630.78 Aspergillus niger CBS 769.97 Niveomyces coronatus CBS 149186 Ophiocordyceps australis 1348a (Ghana) Ophiocordyceps australis map64 (Brazil) Ophiocordyceps camponoti-floridani Ophiocordyceps camponoti-rufipedis Ophiocordyceps kimflemingae Ophiocordyceps subramaniannii Penicillium roqueforti DTO002I6 Penicillium roqueforti DTO003C3 Penicillium roqueforti DTO003H1 (CBS 147308) Penicillium roqueforti DTO006G1 Penicillium roqueforti DTO006G7 Penicillium roqueforti DTO012A1 Penicillium roqueforti DTO012A2 (CBS 147309) Penicillium roqueforti DTO012A6 (CBS 147310) Penicillium roqueforti DTO012A7 Penicillium roqueforti DTO012A8 Penicillium roqueforti DTO012A9 Penicillium roqueforti DTO013E5 Penicillium roqueforti DTO013F2 Penicillium roqueforti DTO013F5 (CBS 147311) Penicillium roqueforti DTO027I6 Penicillium roqueforti DTO032C6 Penicillium roqueforti DTO039G3 Penicillium roqueforti DTO046C5 Penicillium roqueforti DTO070G2 (CBS 147317) Penicillium roqueforti DTO081F9 (CBS 147318) Penicillium roqueforti DTO101D6 (CBS 147325) Penicillium roqueforti DTO102I9 (CBS 147326) Penicillium roqueforti DTO126G2 (CBS 147330) Penicillium roqueforti DTO127F7 (CBS 147331) Penicillium roqueforti DTO127F9 (CBS 147332) Penicillium roqueforti DTO130C1 (CBS 147333) Penicillium roqueforti DTO163C3 (CBS 147337) Penicillium roqueforti DTO163F5 (CBS 147338) Penicillium roqueforti DTO163G4 (CBS 147339) Penicillium roqueforti DTO265D5 (CBS 147372) Penicillium roqueforti DTO369A1 (CBS 147354) Penicillium roqueforti DTO375B1 (CBS 147355) Penicillium roqueforti DTO377G2 (LCP 96.3914a) Penicillium roqueforti LCP96 04111 Rhodonia placenta FPRL280 Torrubiellomyces zombiae CBS 149187

General Properties

Protein ID	Pro_DTO377G3_2|g8915.t1
Gene name
Location	scaffold_38:186225..190490
Strand	+
Gene length (bp)	4265
Transcript length (bp)	3417
Coding sequence length (bp)	3417
Protein length (aa)	1139

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PFAM Domains

PFAM Domain ID	Short name	Long name	E-value	Start	End
PF08767	CRM1_C	CRM1 C terminal	5.2E-136	772	1094
PF08389	Xpo1	Exportin 1-like protein	4.3E-43	170	314
PF18784	CRM1_repeat_2	CRM1 / Exportin repeat 2	1.6E-33	468	535
PF18787	CRM1_repeat_3	CRM1 / Exportin repeat 3	2.5E-28	548	598
PF18777	CRM1_repeat	Chromosome region maintenance or exportin repeat	1.6E-18	393	429
PF03810	IBN_N	Importin-beta N-terminal domain	6.5E-11	92	156

GO

GO Term	Description	Terminal node
GO:0005049	nuclear export signal receptor activity	Yes
GO:0031267	small GTPase binding	Yes
GO:0006886	intracellular protein transport	Yes
GO:0140142	nucleocytoplasmic carrier activity	No
GO:0045184	establishment of protein localization	No
GO:0046907	intracellular transport	No
GO:0051020	GTPase binding	No
GO:0006810	transport	No
GO:0008150	biological_process	No
GO:0140104	molecular carrier activity	No
GO:0019899	enzyme binding	No
GO:0015031	protein transport	No
GO:0051234	establishment of localization	No
GO:0051641	cellular localization	No
GO:0005488	binding	No
GO:0005515	protein binding	No
GO:0071702	organic substance transport	No
GO:0003674	molecular_function	No
GO:0070727	cellular macromolecule localization	No
GO:0051649	establishment of localization in cell	No
GO:0051179	localization	No
GO:0008104	protein localization	No
GO:0071705	nitrogen compound transport	No
GO:0033036	macromolecule localization	No
GO:0009987	cellular process	No

SignalP

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SignalP signal predicted	Location (based on Ymax)	D score (significance: > 0.45)
No	1 - 17	0.45

Transmembrane Domains

(None)

Transcription Factor Class

(None)

Expression data

Analysis 1: Genome-wide gene expression in conidia of Penicillium roqueforti during growth at various temperatures and for various amounts of time. Published in Punt et al., 2020.

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Sequences

Type of sequence	Sequence
Locus	Download genbank file of locus The gene with 5 kb flanks (if sufficient flanking sequence is available). For use in cloning design programs. NOTE: features (genes or exons) that are only partially contained within the sequence are completely excluded.
Protein	>Pro_DTO377G3_2|g8915.t1 MIPGRVWISTPPNTLASYSPLSFDTALQPPWQYHNLSRRFPSSSPLDSRVSNPIPSSEAISPVCAEMSISVQELD NTVRALFEGKGAVQNQAQQTLTEFKQNPDAWVTVGNILQEASYLQTKYIALQVLDNVIMTRWKVLPRDQCQGIRN FIVRFILENSESEEKIQAERPLLNKLNLVLVSILKQEWPHNWPTFINEIISSCHASLSICENNMTILRLLSEEVF DFSQDQMTSAKARNLKTSMTSEFASIFQLCSEVLSTANQPSLVKATLETLLRFLNWIPLGYIFETPIINTLLTRF LGEPEFRNVTLKCLTEIGGLQIGAPYNYDERLVHMFTETLTTVSNVIPLSLDLKQTYAMSNGRDQEFVSNLALFL SSFFSAHLDLIEKLPNQDYLTHAHFYLIRVSQIDDREVFKICLDYWTRLVQELYEEMQQLPITDINPLVSMSVSG LANGGAPNPTTLANYPLRKHKYETVLTNLRTVMIEKMVRPEEVLVVENDEGEIVREFVKESDTIQLYKTIRECLV YLTHLDVVDTETIMVDKLAKQVDGTEWSWVNCNTLCWAIGSISGAMNEETEKRFLVTVIKDLLGLTEQKRGKDNK AVVASNIMYIVGQYPRFLKAHWKFLKTVVNKLFEFMHETHEGVQDMACDTFIKIANKCRRHFVALQPGESEPFIE EIVRNMRKITMDLSPQQIHTFYEACGYMISAQGQKGLQDRLTENLMALPNTAWDQIIAEANQNPAILQDANTIKI VGNIMKTNVAACSSIGTYFYSQIGRIYHDMLNMYRAASQLINDAVASDGAIAPKTPKVRGLRTIKKEILKLIDTY VDKSDDLEMVNASMVPPLMEAVLIDYARNVPDAREAEVLNAMTTIIHKLHNLMEDKIPAIMDSVFNCTLEMINKD FHEYPEHRVEFFKLLQAVNLYCFQALLKLDAAQFKFVIDSCMWASKHDNREVENTGLTMCLELMNNMAETDQQTS SIFFREFYIPILQDVFFVLTDSDHKAGFKSQAMLLSRMFYFVESGKIQQPIYSPEQAPPGTSNKEFLQEHIANLL HNAFGNLQEAQIKQFVIGLFLYTDDLNKFKTHLRDFLISLKEFSDDNAELYAEEREQAVRDAQVAERDRAMKVGG LLKPSEMDQEDEL*
Coding	>Pro_DTO377G3_2|g8915.t1 ATGATCCCTGGGCGAGTCTGGATCTCTACCCCACCGAACACACTTGCTTCTTATTCCCCTCTATCATTTGATACT GCCCTGCAGCCGCCCTGGCAATACCATAACCTGTCCAGGCGGTTCCCATCATCCTCCCCTCTTGACTCTCGTGTC TCAAACCCTATTCCGTCATCAGAGGCGATATCGCCAGTCTGCGCCGAGATGTCGATTTCGGTACAAGAGCTGGAC AACACGGTCCGAGCTTTGTTTGAAGGCAAAGGTGCCGTGCAAAACCAAGCACAGCAGACTTTGACAGAATTCAAG CAAAATCCCGATGCCTGGGTCACCGTGGGCAACATCCTCCAAGAGGCTTCATACCTTCAAACCAAATACATTGCT CTCCAAGTCTTAGACAATGTGATTATGACCCGATGGAAGGTTCTACCAAGAGACCAATGTCAGGGTATCCGCAAT TTTATTGTGCGATTCATTCTCGAAAACTCCGAATCCGAAGAGAAGATCCAAGCGGAGCGCCCTCTGTTGAACAAG CTCAATCTCGTTCTTGTCTCCATTTTGAAGCAAGAATGGCCGCACAACTGGCCCACCTTCATCAATGAGATTATT TCCTCTTGCCATGCCAGCCTTTCGATCTGTGAAAACAACATGACAATTCTCCGTCTGTTGTCGGAAGAAGTCTTC GATTTCTCGCAAGACCAAATGACCTCTGCCAAGGCACGGAACTTAAAGACCTCTATGACCTCGGAATTTGCATCG ATCTTCCAATTGTGCTCCGAGGTTCTCAGCACTGCCAACCAGCCCAGTCTGGTGAAAGCGACCCTCGAAACTCTC CTTCGATTTCTGAACTGGATCCCGTTGGGCTACATTTTCGAAACCCCCATCATCAATACCCTCCTCACCCGATTC CTAGGAGAACCCGAGTTCCGAAATGTGACTTTGAAGTGTCTGACTGAGATTGGTGGCTTGCAAATTGGCGCTCCT TACAACTATGACGAACGATTGGTGCACATGTTCACCGAGACCCTGACCACCGTTTCCAATGTCATTCCTCTGTCC TTGGACCTGAAGCAGACGTATGCCATGAGCAATGGACGAGACCAAGAGTTTGTATCAAACTTGGCCTTGTTCCTC TCGAGCTTTTTCAGTGCTCACCTTGATCTTATCGAAAAGTTGCCTAATCAAGATTACCTCACGCACGCACATTTC TATCTGATTCGGGTCAGCCAGATCGACGATCGGGAGGTGTTCAAGATTTGCTTGGACTACTGGACAAGACTCGTG CAGGAACTTTACGAAGAGATGCAGCAGCTCCCAATCACCGACATCAACCCGCTGGTCTCTATGAGCGTTAGTGGT TTGGCGAACGGTGGTGCCCCCAATCCTACGACCCTAGCGAACTACCCATTGCGCAAGCACAAGTACGAGACTGTG TTAACAAACCTTCGCACCGTGATGATCGAGAAGATGGTCCGCCCAGAGGAGGTCTTGGTTGTGGAAAACGATGAG GGTGAAATTGTGCGCGAGTTCGTTAAGGAGAGTGATACCATCCAACTTTACAAGACGATACGCGAGTGCTTGGTC TACCTGACCCATCTTGATGTGGTCGATACGGAGACTATCATGGTGGATAAATTGGCTAAGCAAGTTGATGGAACC GAATGGTCTTGGGTGAACTGCAACACGCTATGCTGGGCTATTGGTTCGATCTCTGGAGCCATGAACGAGGAAACC GAGAAACGTTTCCTGGTTACCGTAATCAAGGATTTGCTTGGCCTCACAGAGCAGAAGCGCGGGAAGGACAACAAA GCTGTGGTGGCGAGTAACATCATGTACATCGTGGGACAATACCCCCGGTTCTTGAAGGCTCACTGGAAGTTCCTG AAGACGGTCGTCAACAAGTTGTTCGAGTTTATGCACGAGACGCACGAAGGTGTCCAGGATATGGCTTGCGATACG TTCATCAAGATTGCCAACAAGTGCAGACGCCATTTCGTGGCACTTCAACCTGGTGAAAGTGAACCTTTCATCGAA GAAATTGTACGGAACATGAGGAAGATCACCATGGACCTTTCCCCGCAACAGATTCATACCTTCTACGAAGCTTGT GGCTACATGATTTCGGCTCAAGGTCAAAAGGGTCTCCAAGACCGATTGACTGAAAACTTGATGGCGCTCCCTAAC ACCGCCTGGGATCAGATTATCGCGGAGGCAAACCAAAACCCGGCGATTCTCCAAGACGCCAACACCATCAAGATT GTCGGAAACATCATGAAGACTAATGTCGCAGCTTGCTCCTCGATTGGGACCTACTTTTATTCTCAAATTGGTCGG ATCTATCACGACATGTTGAATATGTACCGTGCTGCCAGTCAGCTGATTAATGATGCTGTTGCAAGTGATGGAGCT ATTGCACCCAAAACCCCCAAGGTCCGAGGACTTCGGACCATCAAGAAAGAGATCTTGAAGCTCATTGACACCTAC GTGGACAAGTCAGATGACCTTGAGATGGTCAATGCCAGCATGGTACCGCCGCTCATGGAGGCTGTACTGATCGAT TATGCCCGGAACGTCCCCGATGCACGCGAGGCTGAGGTCTTGAATGCCATGACTACGATCATCCACAAACTTCAC AATCTGATGGAGGATAAGATTCCAGCCATCATGGACAGCGTTTTCAACTGCACTCTTGAGATGATCAACAAGGAC TTCCACGAATATCCTGAGCACCGGGTCGAGTTCTTCAAATTGCTTCAAGCTGTCAACCTGTACTGCTTCCAAGCA CTTCTGAAGCTCGATGCTGCGCAGTTCAAGTTTGTCATTGATTCATGCATGTGGGCGTCGAAGCATGACAACCGC GAGGTGGAGAACACTGGCCTTACGATGTGTTTGGAGCTGATGAACAACATGGCCGAAACTGACCAGCAAACCTCG AGCATTTTCTTCCGCGAGTTTTACATTCCAATTCTTCAGGATGTCTTCTTTGTCCTCACGGATAGTGACCACAAG GCTGGATTCAAATCCCAGGCCATGCTTTTGTCGCGCATGTTCTACTTTGTGGAATCAGGCAAAATCCAGCAGCCT ATCTACTCCCCCGAGCAAGCCCCGCCTGGAACTTCAAACAAAGAATTTTTGCAGGAGCACATCGCAAATCTGCTA CACAATGCATTCGGCAATCTCCAAGAAGCACAAATCAAGCAGTTTGTTATTGGGCTGTTTTTATACACTGATGAC CTAAACAAATTCAAGACTCACCTTCGTGATTTCTTGATTTCTCTGAAAGAGTTTTCCGATGACAACGCGGAGCTG TATGCGGAAGAACGAGAACAGGCGGTGCGTGATGCCCAGGTTGCCGAGCGTGACCGAGCTATGAAGGTCGGAGGG CTGTTGAAGCCATCGGAGATGGATCAGGAGGATGAGCTATGA
Transcript	>Pro_DTO377G3_2|g8915.t1 ATGATCCCTGGGCGAGTCTGGATCTCTACCCCACCGAACACACTTGCTTCTTATTCCCCTCTATCATTTGATACT GCCCTGCAGCCGCCCTGGCAATACCATAACCTGTCCAGGCGGTTCCCATCATCCTCCCCTCTTGACTCTCGTGTC TCAAACCCTATTCCGTCATCAGAGGCGATATCGCCAGTCTGCGCCGAGATGTCGATTTCGGTACAAGAGCTGGAC AACACGGTCCGAGCTTTGTTTGAAGGCAAAGGTGCCGTGCAAAACCAAGCACAGCAGACTTTGACAGAATTCAAG CAAAATCCCGATGCCTGGGTCACCGTGGGCAACATCCTCCAAGAGGCTTCATACCTTCAAACCAAATACATTGCT CTCCAAGTCTTAGACAATGTGATTATGACCCGATGGAAGGTTCTACCAAGAGACCAATGTCAGGGTATCCGCAAT TTTATTGTGCGATTCATTCTCGAAAACTCCGAATCCGAAGAGAAGATCCAAGCGGAGCGCCCTCTGTTGAACAAG CTCAATCTCGTTCTTGTCTCCATTTTGAAGCAAGAATGGCCGCACAACTGGCCCACCTTCATCAATGAGATTATT TCCTCTTGCCATGCCAGCCTTTCGATCTGTGAAAACAACATGACAATTCTCCGTCTGTTGTCGGAAGAAGTCTTC GATTTCTCGCAAGACCAAATGACCTCTGCCAAGGCACGGAACTTAAAGACCTCTATGACCTCGGAATTTGCATCG ATCTTCCAATTGTGCTCCGAGGTTCTCAGCACTGCCAACCAGCCCAGTCTGGTGAAAGCGACCCTCGAAACTCTC CTTCGATTTCTGAACTGGATCCCGTTGGGCTACATTTTCGAAACCCCCATCATCAATACCCTCCTCACCCGATTC CTAGGAGAACCCGAGTTCCGAAATGTGACTTTGAAGTGTCTGACTGAGATTGGTGGCTTGCAAATTGGCGCTCCT TACAACTATGACGAACGATTGGTGCACATGTTCACCGAGACCCTGACCACCGTTTCCAATGTCATTCCTCTGTCC TTGGACCTGAAGCAGACGTATGCCATGAGCAATGGACGAGACCAAGAGTTTGTATCAAACTTGGCCTTGTTCCTC TCGAGCTTTTTCAGTGCTCACCTTGATCTTATCGAAAAGTTGCCTAATCAAGATTACCTCACGCACGCACATTTC TATCTGATTCGGGTCAGCCAGATCGACGATCGGGAGGTGTTCAAGATTTGCTTGGACTACTGGACAAGACTCGTG CAGGAACTTTACGAAGAGATGCAGCAGCTCCCAATCACCGACATCAACCCGCTGGTCTCTATGAGCGTTAGTGGT TTGGCGAACGGTGGTGCCCCCAATCCTACGACCCTAGCGAACTACCCATTGCGCAAGCACAAGTACGAGACTGTG TTAACAAACCTTCGCACCGTGATGATCGAGAAGATGGTCCGCCCAGAGGAGGTCTTGGTTGTGGAAAACGATGAG GGTGAAATTGTGCGCGAGTTCGTTAAGGAGAGTGATACCATCCAACTTTACAAGACGATACGCGAGTGCTTGGTC TACCTGACCCATCTTGATGTGGTCGATACGGAGACTATCATGGTGGATAAATTGGCTAAGCAAGTTGATGGAACC GAATGGTCTTGGGTGAACTGCAACACGCTATGCTGGGCTATTGGTTCGATCTCTGGAGCCATGAACGAGGAAACC GAGAAACGTTTCCTGGTTACCGTAATCAAGGATTTGCTTGGCCTCACAGAGCAGAAGCGCGGGAAGGACAACAAA GCTGTGGTGGCGAGTAACATCATGTACATCGTGGGACAATACCCCCGGTTCTTGAAGGCTCACTGGAAGTTCCTG AAGACGGTCGTCAACAAGTTGTTCGAGTTTATGCACGAGACGCACGAAGGTGTCCAGGATATGGCTTGCGATACG TTCATCAAGATTGCCAACAAGTGCAGACGCCATTTCGTGGCACTTCAACCTGGTGAAAGTGAACCTTTCATCGAA GAAATTGTACGGAACATGAGGAAGATCACCATGGACCTTTCCCCGCAACAGATTCATACCTTCTACGAAGCTTGT GGCTACATGATTTCGGCTCAAGGTCAAAAGGGTCTCCAAGACCGATTGACTGAAAACTTGATGGCGCTCCCTAAC ACCGCCTGGGATCAGATTATCGCGGAGGCAAACCAAAACCCGGCGATTCTCCAAGACGCCAACACCATCAAGATT GTCGGAAACATCATGAAGACTAATGTCGCAGCTTGCTCCTCGATTGGGACCTACTTTTATTCTCAAATTGGTCGG ATCTATCACGACATGTTGAATATGTACCGTGCTGCCAGTCAGCTGATTAATGATGCTGTTGCAAGTGATGGAGCT ATTGCACCCAAAACCCCCAAGGTCCGAGGACTTCGGACCATCAAGAAAGAGATCTTGAAGCTCATTGACACCTAC GTGGACAAGTCAGATGACCTTGAGATGGTCAATGCCAGCATGGTACCGCCGCTCATGGAGGCTGTACTGATCGAT TATGCCCGGAACGTCCCCGATGCACGCGAGGCTGAGGTCTTGAATGCCATGACTACGATCATCCACAAACTTCAC AATCTGATGGAGGATAAGATTCCAGCCATCATGGACAGCGTTTTCAACTGCACTCTTGAGATGATCAACAAGGAC TTCCACGAATATCCTGAGCACCGGGTCGAGTTCTTCAAATTGCTTCAAGCTGTCAACCTGTACTGCTTCCAAGCA CTTCTGAAGCTCGATGCTGCGCAGTTCAAGTTTGTCATTGATTCATGCATGTGGGCGTCGAAGCATGACAACCGC GAGGTGGAGAACACTGGCCTTACGATGTGTTTGGAGCTGATGAACAACATGGCCGAAACTGACCAGCAAACCTCG AGCATTTTCTTCCGCGAGTTTTACATTCCAATTCTTCAGGATGTCTTCTTTGTCCTCACGGATAGTGACCACAAG GCTGGATTCAAATCCCAGGCCATGCTTTTGTCGCGCATGTTCTACTTTGTGGAATCAGGCAAAATCCAGCAGCCT ATCTACTCCCCCGAGCAAGCCCCGCCTGGAACTTCAAACAAAGAATTTTTGCAGGAGCACATCGCAAATCTGCTA CACAATGCATTCGGCAATCTCCAAGAAGCACAAATCAAGCAGTTTGTTATTGGGCTGTTTTTATACACTGATGAC CTAAACAAATTCAAGACTCACCTTCGTGATTTCTTGATTTCTCTGAAAGAGTTTTCCGATGACAACGCGGAGCTG TATGCGGAAGAACGAGAACAGGCGGTGCGTGATGCCCAGGTTGCCGAGCGTGACCGAGCTATGAAGGTCGGAGGG CTGTTGAAGCCATCGGAGATGGATCAGGAGGATGAGCTATGA
Gene	>Pro_DTO377G3_2|g8915.t1 ATGATCCCTGGGCGGTATCCCCGGGCGGTGGGGGATCGCATGCTGACTAAGATCTCAACAGAGGGATCAAGTTCA AACATCCAACGCGCTCTCACCGCCAGAGTCTACGATAGCTTCCTTTTTTGACCCCCAATTTTCCTGCCTGTTTTT TTTACTGCCTTCAGAGTCTGGTAAGTCTTGACCTGGATTCACCTCCTCTAGTCCCCCGTCCAATCATTTCTCATC CTGACATCGTGCTGATCCCCCAACCCCTCCAAAGGATCTCTACCCCACCGAACACACTTGCTTCTTATTCCCCTC TATCATTTGATACTGCCCTGCAGCCGCCCTGGCAATACCATAACCTGTCCAGGCGGTTCCCATCATCCTCCCCTC TTGACTCTCGTGTCTCAAACCCTATTCCGTCATCAGAGGCGATATCGCCAGTCTGCGCCGAGATGTCGATTTCGG TACAAGAGCTGGACAACACGGTCCGAGCTTTGTTTGAAGGCAAAGGTGCCGTGGTAAGTCGAACCTGTCTCCTCT ACACGGCTTGGGTCGCAGAATTCATGGAATCTGTGTATCCTCCGTGGAGCTCTGGGGACACCAACACTGACATTG AGAACCGTCTAGCAAAACCAAGCACAGCAGACTTTGACAGAAGTAAGCGCATAGCCCCTCCACAACGTCATATGA ATTGAACACTAATAATCCCTGTGCTATTAGTTCAAGCAAAATCCCGATGCCTGGGTCACCGTGGGCAACATCCTC CAAGAGGCTTCATACCTTCAAACCAAATGTGTGTCTTGAGTCTTTGGCAATCTCCCTTGTGCCTGGAAATGCCTG GGAAACACTTGCTGATTTTCACAGACATTGCTCTCCAAGTCTTAGACAATGTGATTATGACCCGATGGAAGGTTC TACCAAGAGACCAATGTCAGGGTAAGAACTACATGCATTGACCTCGTCGTTTTACCTCCCCATACTAAGAACGTT CTTCATAGGTATCCGCAATTTTATTGTGCGATTCATTCTCGAAAACTCCGAATCCGAAGAGAAGATCCAAGCGGA GCGCCCTCTGTTGAACAAGCTCAATCTCGTTCTTGTCTCCATTTTGAAGCAAGAATGGCCGCACAACTGGCCCAC CTTCATCAATGAGATTATTTCCTCTTGCCATGCCAGCCTTTCGATCTGTGAAAACAACATGACAATTCTCCGTCT GTTGTCGGAAGAAGTCTTCGATTTCTCGCAAGACCAAATGACCTCTGCCAAGGCACGGAACTTAAAGACCTCTAT GACCTCGGAATTTGCATCGATCTTCCAATTGTGCTCCGAGGTTCTCAGCACTGCCAACCAGCCCAGTCTGGTGAA AGCGACCCTCGAAACTCTCCTTCGATTTCTGAACTGGATCCCGTTGGGCTACATTTTCGAAACCCCCATCATCAA TACCCTCCTCACCCGATTCCTAGGAGAACCCGAGTTCCGAAATGTGACTTTGAAGTGTCTGACTGAGATTGGTGG CTTGCAAATTGGCGCTCCTTACAACTATGACGAACGATTGGTGCACATGTTCACCGAGACCCTGACCACCGTTTC CAATGTCATTCCTCTGTCCTTGGACCTGAAGCAGACGTATGCCATGAGCAATGGACGAGACCAAGAGTTTGTATC AAACTTGGCCTTGTTCCTCTCGAGCTTTTTCAGTGCTCACCTTGATGTATGCTCCCTTTTCCTTTAACCATGTTT TTTTAGTCTGTTTGATGCTAACCTTTTCCTTCTTTTATAGCTTATCGAAAAGTTGCCTAATCAAGATTACCTCAC GCACGCACATTTCTATCTGATTCGGGTCAGCCAGATCGACGATCGGGAGGTGTTCAAGATTTGCTTGGACTACTG GACAAGACTCGTGCAGGAACTTTACGAAGAGATGCAGCAGCTCCCAATCACCGACATCAACCCGCTGGTCTCTAT GAGCGTTAGTGGTTTGGCGAACGGTGGTGCCCCCAATCCTACGACCCTAGCGAACTACCCATTGCGCAAGCACAA GTACGAGACTGTGTTAACAAACCTTCGCACCGTGATGATCGAGAAGATGGTCCGCCCAGAGGAGGTCTTGGTTGT GGAAAACGATGAGGGTGAAATTGTGCGCGAGTTCGTTAAGGAGAGTGATACCATCCAACTTTACAAGACGATACG CGAGTGCTTGGTCTACCTGACCCATCTTGATGTGGTCGATACGGAGACTATCATGGTGGATAAATTGGCTAAGCA AGTTGATGGAACCGAATGGTCTTGGGTGAACTGCAACACGCTATGCTGGGCTATTGGTTCGATCTCTGGAGCCAT GAACGAGGAAACCGAGAAACGTTTCCTGGTTACCGTAATCAAGGATTTGCTTGGCCTCACAGAGCAGAAGCGCGG GAAGGACAACAAAGCTGTGGTGGCGAGTAACATCATGTACATCGTGGGACAATACCCCCGGTTCTTGAAGGCTCA CTGGAAGTTCCTGAAGACGGTCGTCAACAAGTTGTTCGAGTTTATGCACGAGACGCACGAAGGTGTCCAGGATAT GGCTTGCGATACGTTCATCAAGATTGCCAACAAGTGCAGACGCCATTTCGTGGCACTTCAACCTGGTGAAAGTGA ACCTTTCATCGAAGAAATTGTACGGAACATGAGGAAGATCACCATGGACCTTTCCCCGCAACAGATTCATACCTT CTACGAAGCTTGTGGCTACATGATTTCGGCTCAAGGTCAAAAGGGTCTCCAAGACCGATTGACTGAAAACTTGAT GGCGCTCCCTAACACCGCCTGGGATCAGATTATCGCGGAGGCAAACCAAAACCCGGCGATTCTCCAAGACGCCAA CACCATCAAGATTGTCGGAAACATCATGAAGACTAATGTCGCAGCTTGCTCCTCGATTGGGACCTACTTTTATTC TCAAATTGGTCGGATCTATCACGACATGTTGAATATGTACCGTGCTGCCAGTCAGCTGATTAATGATGCTGTTGC AAGTGATGGTAACTAATCCAATTCACGCTGACGGACACCGAATTTCTTACTGACACAAAAATAGGAGCTATTGCA CCCAAAACCCCCAAGGTCCGAGGACTTCGGACCATCAAGAAAGAGATCTTGAAGCTCATTGACACCTACGTGGAC AAGTCAGATGACCTTGAGATGGTCAATGCCAGCATGGTACCGCCGCTCATGGAGGCTGTACTGATCGATTATGCC CGGAACGTCCCCGATGCACGCGAGGCTGAGGTCTTGAATGCCATGACTACGATCATCCACAAACTTCACGTATGT TTTTCGCCCTGCTGATTATTGGTGCCCTTATTTGATAGCCTGCTAACATGTCAATCAGAATCTGATGGAGGATAA GATTCCAGCCATCATGGACAGCGTTTTCAACTGCACTCTTGAGATGATCAACAAGGACTTCCACGAATATCCTGA GCACCGGGTCGAGTTCTTCAAATTGCTTCAAGCTGTCAACCTGTACTGCTTCCAAGCACTTCTGAAGCTCGATGC TGCGCAGTTCAAGTTTGTCATTGATTCATGCATGTGGGCGTCGAAGCATGACAACCGCGAGGTGGAGAACACTGG CCTTACGATGTGTTTGGAGCTGATGAACAACATGGCCGAAACTGACCAGCAAACCTCGAGCATTTTCTTCCGCGA GTTTTACATTCCAATTCTTCAGGATGTCTTCTTTGTCCTCACGGATAGTGACCACAAGGCTGGTAAGTAATGTCC TTTGTCCGGATATGAAGCAAGAAGCTAACAATCCGATTTTTTAGGATTCAAATCCCAGGCCATGCTTTTGTCGCG CATGTTCTACTTTGTGGAATCAGGCAAAATCCAGCAGCCTATCTACTCCCCCGAGCAAGCCCCGCCTGGAACTTC AAACAAAGAATTTTTGCAGGAGCACATCGCAAATCTGCTACACAATGCATTCGGCAATCTCCAAGAGTAAGCTCC CTCGGCGTCGGTTGAAACCATGCAAGAGTATACTAACTTTCTCCACCAGAGCACAAATCAAGCAGTTTGTTATTG GGCTGTTTTTATACACTGATGACCTAAACAAATTCAAGACTCACCTTCGTGATTTCTTGATTTCTCTGAAAGAGT TTTCCGATGACAACGCGGAGCTGTATGCGGAAGAACGAGAACAGGCGGTGCGTGATGCCCAGGTTGCCGAGCGTG ACCGAGCTATGAAGGTCGGAGGGCTGTTGAAGCCATCGGAGATGGATCAGGAGGATGAGCTATGA