Fungal Genomics

Agaricus bisporus var bisporus H39 Agaricus bisporus var bisporus H97 Agaricus bisporus var burnettii H119p4 Ophiocordyceps australis 1348a (Ghana) Ophiocordyceps australis map64 (Brazil) Ophiocordyceps camponoti-floridani Ophiocordyceps camponoti-rufipedis Ophiocordyceps kimflemingae Ophiocordyceps subramaniannii Penicillium roqueforti DTO002I6 Penicillium roqueforti DTO003C3 Penicillium roqueforti DTO003H1 (CBS 147308) Penicillium roqueforti DTO006G1 Penicillium roqueforti DTO006G7 Penicillium roqueforti DTO012A1 Penicillium roqueforti DTO012A2 (CBS 147309) Penicillium roqueforti DTO012A6 (CBS 147310) Penicillium roqueforti DTO012A7 Penicillium roqueforti DTO012A8 Penicillium roqueforti DTO012A9 Penicillium roqueforti DTO013E5 Penicillium roqueforti DTO013F2 Penicillium roqueforti DTO013F5 (CBS 147311) Penicillium roqueforti DTO027I6 Penicillium roqueforti DTO032C6 Penicillium roqueforti DTO039G3 Penicillium roqueforti DTO046C5 Penicillium roqueforti DTO070G2 (CBS 147317) Penicillium roqueforti DTO081F9 (CBS 147318) Penicillium roqueforti DTO101D6 (CBS 147325) Penicillium roqueforti DTO102I9 (CBS 147326) Penicillium roqueforti DTO126G2 (CBS 147330) Penicillium roqueforti DTO127F7 (CBS 147331) Penicillium roqueforti DTO127F9 (CBS 147332) Penicillium roqueforti DTO130C1 (CBS 147333) Penicillium roqueforti DTO163C3 (CBS 147337) Penicillium roqueforti DTO163F5 (CBS 147338) Penicillium roqueforti DTO163G4 (CBS 147339) Penicillium roqueforti DTO265D5 (CBS 147372) Penicillium roqueforti DTO369A1 (CBS 147354) Penicillium roqueforti DTO375B1 (CBS 147355) Penicillium roqueforti DTO377G2 (LCP 96.3914a) Penicillium roqueforti LCP96 04111 Rhodonia placenta FPRL280

General Properties

Protein ID	Pro_DTO377G3_2|g8558.t1
Gene name
Location	scaffold_34:146986..151108
Strand	-
Gene length (bp)	4122
Transcript length (bp)	3900
Coding sequence length (bp)	3900
Protein length (aa)	1300

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PFAM Domains

PFAM Domain ID	Short name	Long name	E-value	Start	End
PF08148	DSHCT	DSHCT (NUC185) domain	5.9E-52	1123	1294
PF17911	Ski2_N	Ski2 N-terminal region	1.0E-40	74	218
PF13234	rRNA_proc-arch	rRNA-processing arch domain	9.5E-25	828	1095
PF00270	DEAD	DEAD/DEAH box helicase	3.2E-17	325	470
PF00271	Helicase_C	Helicase conserved C-terminal domain	1.7E-05	688	771

GO

GO Term	Description	Terminal node
GO:0005524	ATP binding	Yes
GO:0003676	nucleic acid binding	Yes
GO:0000166	nucleotide binding	No
GO:0008144	drug binding	No
GO:0003674	molecular_function	No
GO:0043167	ion binding	No
GO:0032553	ribonucleotide binding	No
GO:0017076	purine nucleotide binding	No
GO:0035639	purine ribonucleoside triphosphate binding	No
GO:0097367	carbohydrate derivative binding	No
GO:0030554	adenyl nucleotide binding	No
GO:1901265	nucleoside phosphate binding	No
GO:0005488	binding	No
GO:1901363	heterocyclic compound binding	No
GO:0032559	adenyl ribonucleotide binding	No
GO:0043168	anion binding	No
GO:0032555	purine ribonucleotide binding	No
GO:0036094	small molecule binding	No
GO:0097159	organic cyclic compound binding	No

SignalP

[Help with interpreting these statistics]

SignalP signal predicted	Location (based on Ymax)	D score (significance: > 0.45)
No	1 - 45	0.45

Transmembrane Domains

(None)

Transcription Factor Class

(None)

Expression data

Analysis 1: Genome-wide gene expression in conidia of Penicillium roqueforti during growth at various temperatures and for various amounts of time. Published in Punt et al., 2020.

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Sequences

Type of sequence	Sequence
Locus	Download genbank file of locus The gene with 5 kb flanks (if sufficient flanking sequence is available). For use in cloning design programs. NOTE: features (genes or exons) that are only partially contained within the sequence are completely excluded.
Protein	>Pro_DTO377G3_2|g8558.t1 MADSLDSTMKELDIEGRHFDPATFDARLADEEDGKIENFQARKQAPQSAQELLTELENEFLTPSDQFSTKWLNSL QKRWDVSTDYADLFELAPTQTRTVTRFTREGLEGRVTGYQEVTVPAASATAKNSTSLLRRPAGRADFVRGAAGFF PFAPGGLDAIEALAAMEADAQVTEQSTKGKQSGLDRIINFGTEGGLLTTPPGFDNGIDFDEAKSKAATEGAQEVE TALLQEESDLKVDQPEESADVELGAEVELDDISDDEEEEDIDALLPVEFPALEPRSQLLAGVKQKGREWAHVVDV NKDIPNFNELVPDMAREWPFELDTFQKEAVYHLENGDSVFVAAHTSAGKTVVAEYAIALAAKHMTKAIYTSPIKA LSNQKYRDFRTEFDDVGILTGDVQINPEASCLIMTTEILRSMLYRGADLIRDVEFVIFDEVHYVNDLERGVVWEE VIIMLPEHVTLILLSATVPNTREFASWVGRTKKKDIYVISTHKRPVPLEHYLWAGKSKHKIVDSNKRFLESGWKE ADDILSGKDKAKAKKEAEAQAQSAQARAPAPQGRGRGQPANNRGGRGGPQRGGPQRGRGQSGGQYSNRGTGNIAR TGRGGGRTSAAQDKNTWVHLVSHLRKEDLLPGCVFVFSKKRCEENADSLSNQDFSNANEKSLTHMFIEKSLTRLK PEDRTLPQILRLRELLSRGIAVHHGGLLPIMKEVVEILFARSLVKVLFATETFAMGLNLPTRTVVFSGFRKHDGK SFRDLLPGEYTQMAGRAGRRGLDTVGYVIVTNSGKDEAPSAASLKQMILGDPTKLRSQFRLTYNMILNLLRVEAL KIEEMIKRSFSENATQALLPEHEKQVQVSEASLAKIKRAPCEICDLDLLTCHNAAMEYRKLTAEFHTELLSSPVG KRLFTMKRLVVYRKDGLRTAGVITRDGVSPGVIGAVPCIQVLEIGTLSSKRHPTDILPFLPLFRPYFQPLPNRVD DMSLRVCKIPLSDLECVTNTQVKITKPMWYLNIKKESMKWAETELCQFTNSWIDTAWDEIDWQRIKEMEIRDILD KRQVQAEIAQSCHCLQCPDFVNHFEMQHDEWQVKENISELKQLMSDQNLQLLPDYEQRIHVLRELGFVDEQSRVQ LKGKVACEIHSADELVLTELVLENVLAEYEPEEIVALLSAFVFQEKTDSTPTLTPRLEKGQKEIIRIAEKVNDFQ ILHQVIQSSEDSNDFASKPRFGLAEVVYEWAKGMSFNRITDLTDVMEGTIVRVITRLDETCREVKNAAKLVGDPT LYTKMQQAQELIKRDVIFAASLYM*
Coding	>Pro_DTO377G3_2|g8558.t1 ATGGCCGACTCGCTCGATTCCACAATGAAGGAGCTAGACATAGAAGGCAGACACTTCGACCCCGCGACCTTCGAT GCTCGTCTCGCAGACGAAGAGGATGGCAAGATCGAGAACTTCCAAGCTCGGAAGCAGGCCCCTCAGAGTGCGCAA GAGTTGCTAACAGAGCTCGAAAATGAGTTTCTGACCCCATCGGACCAATTCAGCACTAAATGGTTGAACTCTCTC CAAAAACGATGGGACGTTTCGACAGACTATGCAGACCTTTTCGAACTCGCGCCAACACAAACACGGACAGTAACG CGATTTACACGAGAGGGACTGGAAGGACGCGTCACTGGATATCAAGAAGTCACGGTTCCTGCTGCAAGCGCAACG GCCAAGAATTCCACCTCGCTTCTCCGCCGACCTGCTGGTCGTGCCGACTTTGTCAGAGGTGCCGCAGGTTTCTTT CCGTTCGCACCCGGAGGCTTGGACGCTATCGAGGCCTTGGCAGCAATGGAGGCCGATGCTCAGGTCACAGAACAA TCGACCAAGGGGAAACAATCTGGACTCGATCGCATCATCAACTTTGGCACCGAGGGAGGTCTTCTGACAACACCC CCTGGCTTCGATAACGGTATCGATTTCGATGAAGCAAAATCTAAAGCCGCCACCGAAGGTGCCCAAGAAGTCGAA ACCGCCCTTCTCCAAGAGGAAAGTGACCTGAAGGTGGATCAACCCGAGGAATCTGCGGATGTCGAATTAGGAGCA GAGGTCGAGCTTGATGATATCAGCGACGATGAAGAAGAAGAAGATATTGACGCTTTGCTACCAGTTGAGTTCCCG GCGTTGGAGCCGCGTAGCCAGTTGCTTGCAGGTGTCAAGCAAAAAGGTAGAGAATGGGCCCACGTTGTCGATGTC AACAAGGATATTCCCAACTTCAATGAGTTGGTTCCAGATATGGCCAGAGAGTGGCCATTCGAGCTCGACACTTTC CAAAAGGAGGCTGTTTACCACCTCGAAAATGGCGATTCGGTGTTTGTTGCAGCCCATACCTCGGCAGGCAAGACA GTTGTGGCTGAATATGCAATCGCCTTGGCTGCTAAGCATATGACCAAAGCAATCTATACTTCTCCCATCAAAGCG CTGAGCAACCAGAAATACCGTGATTTCAGAACCGAATTCGACGATGTCGGCATTCTGACTGGTGATGTTCAAATC AACCCGGAAGCGAGCTGTCTCATTATGACCACTGAGATCTTGCGAAGTATGCTGTACCGAGGTGCTGATCTCATC CGGGACGTTGAATTCGTCATTTTTGATGAGGTGCATTATGTGAACGACCTCGAACGAGGAGTGGTATGGGAAGAA GTCATCATTATGCTTCCCGAGCATGTCACGTTGATTCTTCTCTCTGCCACTGTTCCCAATACTCGGGAGTTTGCA TCCTGGGTGGGCCGTACAAAGAAGAAGGACATTTATGTAATTTCAACCCATAAGCGACCTGTCCCGCTGGAGCAC TATCTCTGGGCCGGGAAGAGCAAGCACAAGATCGTCGACTCCAACAAAAGATTCCTTGAGAGTGGCTGGAAGGAA GCGGATGATATCCTGTCCGGCAAAGATAAGGCCAAAGCTAAGAAGGAGGCTGAAGCTCAGGCGCAGTCGGCGCAA GCTAGAGCACCAGCTCCCCAGGGCCGAGGCCGCGGTCAGCCAGCGAATAACAGAGGCGGCCGCGGCGGCCCACAG CGTGGAGGCCCGCAACGAGGTCGAGGACAGAGCGGTGGACAGTACTCCAACCGAGGCACGGGTAACATCGCTCGT ACAGGCCGTGGTGGTGGTCGTACAAGTGCGGCCCAGGACAAAAACACTTGGGTGCATCTTGTTTCGCATCTTCGC AAAGAAGACTTGCTGCCGGGATGTGTCTTCGTTTTCTCTAAGAAACGATGCGAGGAGAACGCAGATTCACTTTCA AACCAAGACTTCAGCAATGCCAACGAGAAGAGTTTGACACACATGTTCATTGAAAAGTCACTCACTCGATTAAAG CCCGAGGACCGTACGCTGCCGCAAATCCTTCGCCTGCGCGAGCTATTAAGCAGAGGCATTGCTGTACACCATGGT GGTCTCCTGCCCATCATGAAGGAAGTTGTTGAGATTCTCTTCGCTAGGTCTCTGGTCAAGGTTCTGTTCGCCACA GAGACCTTCGCGATGGGCTTGAATCTTCCCACCCGAACTGTGGTATTCTCCGGGTTCCGCAAGCACGACGGCAAA AGCTTCCGTGATCTCCTGCCCGGCGAATATACGCAAATGGCTGGACGTGCTGGTCGTAGAGGTCTTGACACGGTG GGATATGTCATCGTGACAAACAGTGGAAAAGACGAGGCCCCATCTGCTGCCTCGTTGAAACAGATGATTCTTGGA GATCCGACAAAGCTCAGATCTCAATTCCGACTCACATACAACATGATACTAAATCTGTTGCGTGTGGAAGCCCTG AAGATCGAGGAAATGATCAAGCGGAGTTTCAGTGAAAACGCAACACAAGCCCTCTTACCAGAACACGAGAAGCAA GTCCAGGTATCTGAGGCCAGTCTTGCGAAAATCAAACGGGCACCATGTGAGATCTGTGATTTGGATCTATTGACC TGCCATAACGCCGCCATGGAGTATCGAAAGCTCACAGCTGAGTTCCACACCGAACTGCTATCATCGCCTGTCGGC AAACGTCTTTTCACAATGAAGAGGTTGGTTGTGTACCGCAAGGATGGACTCCGTACTGCTGGTGTTATTACGCGC GACGGAGTTTCTCCCGGAGTCATTGGGGCCGTGCCCTGTATTCAAGTACTTGAGATTGGAACCTTGAGTAGCAAG CGGCACCCCACTGACATTCTTCCATTCTTACCTTTATTCAGACCCTACTTCCAACCACTCCCCAATCGTGTAGAT GACATGAGCCTTCGAGTGTGCAAGATTCCGTTATCCGATCTCGAGTGCGTGACAAACACCCAGGTTAAAATCACA AAACCAATGTGGTATCTGAATATTAAGAAGGAGTCTATGAAGTGGGCAGAAACAGAACTATGCCAGTTCACCAAC TCTTGGATCGATACGGCCTGGGACGAGATCGACTGGCAACGTATCAAAGAAATGGAAATCCGCGATATCCTCGAC AAACGACAAGTTCAGGCAGAGATTGCCCAGTCATGCCACTGTCTACAATGTCCTGATTTCGTAAACCATTTCGAA ATGCAACACGACGAGTGGCAAGTTAAAGAAAACATCTCGGAGTTGAAGCAGCTGATGTCCGACCAAAACCTCCAA CTACTTCCGGATTATGAGCAGCGCATTCACGTACTGAGGGAGCTCGGCTTTGTTGACGAACAATCTCGTGTACAA CTGAAGGGCAAGGTGGCATGCGAAATTCACTCCGCCGACGAGTTGGTCTTAACCGAATTGGTTCTCGAGAACGTT CTTGCTGAATACGAGCCGGAGGAGATTGTTGCACTCCTCTCTGCATTTGTGTTCCAGGAAAAGACAGACAGCACT CCCACCCTCACTCCACGTCTGGAGAAGGGCCAGAAGGAGATCATTCGTATCGCCGAGAAAGTGAATGATTTCCAG ATTCTGCACCAGGTCATTCAATCTAGTGAAGATTCCAACGACTTCGCTAGTAAGCCACGCTTCGGTCTCGCTGAA GTTGTTTATGAGTGGGCCAAGGGAATGTCTTTCAATCGCATCACTGACCTCACGGACGTAATGGAGGGTACTATT GTTCGGGTGATCACCCGACTGGACGAGACTTGTCGCGAAGTGAAGAATGCGGCCAAACTGGTCGGAGACCCGACA CTTTACACTAAGATGCAGCAAGCTCAGGAGTTGATCAAGCGCGATGTCATCTTCGCGGCCTCTCTTTACATGTGA
Transcript	>Pro_DTO377G3_2|g8558.t1 ATGGCCGACTCGCTCGATTCCACAATGAAGGAGCTAGACATAGAAGGCAGACACTTCGACCCCGCGACCTTCGAT GCTCGTCTCGCAGACGAAGAGGATGGCAAGATCGAGAACTTCCAAGCTCGGAAGCAGGCCCCTCAGAGTGCGCAA GAGTTGCTAACAGAGCTCGAAAATGAGTTTCTGACCCCATCGGACCAATTCAGCACTAAATGGTTGAACTCTCTC CAAAAACGATGGGACGTTTCGACAGACTATGCAGACCTTTTCGAACTCGCGCCAACACAAACACGGACAGTAACG CGATTTACACGAGAGGGACTGGAAGGACGCGTCACTGGATATCAAGAAGTCACGGTTCCTGCTGCAAGCGCAACG GCCAAGAATTCCACCTCGCTTCTCCGCCGACCTGCTGGTCGTGCCGACTTTGTCAGAGGTGCCGCAGGTTTCTTT CCGTTCGCACCCGGAGGCTTGGACGCTATCGAGGCCTTGGCAGCAATGGAGGCCGATGCTCAGGTCACAGAACAA TCGACCAAGGGGAAACAATCTGGACTCGATCGCATCATCAACTTTGGCACCGAGGGAGGTCTTCTGACAACACCC CCTGGCTTCGATAACGGTATCGATTTCGATGAAGCAAAATCTAAAGCCGCCACCGAAGGTGCCCAAGAAGTCGAA ACCGCCCTTCTCCAAGAGGAAAGTGACCTGAAGGTGGATCAACCCGAGGAATCTGCGGATGTCGAATTAGGAGCA GAGGTCGAGCTTGATGATATCAGCGACGATGAAGAAGAAGAAGATATTGACGCTTTGCTACCAGTTGAGTTCCCG GCGTTGGAGCCGCGTAGCCAGTTGCTTGCAGGTGTCAAGCAAAAAGGTAGAGAATGGGCCCACGTTGTCGATGTC AACAAGGATATTCCCAACTTCAATGAGTTGGTTCCAGATATGGCCAGAGAGTGGCCATTCGAGCTCGACACTTTC CAAAAGGAGGCTGTTTACCACCTCGAAAATGGCGATTCGGTGTTTGTTGCAGCCCATACCTCGGCAGGCAAGACA GTTGTGGCTGAATATGCAATCGCCTTGGCTGCTAAGCATATGACCAAAGCAATCTATACTTCTCCCATCAAAGCG CTGAGCAACCAGAAATACCGTGATTTCAGAACCGAATTCGACGATGTCGGCATTCTGACTGGTGATGTTCAAATC AACCCGGAAGCGAGCTGTCTCATTATGACCACTGAGATCTTGCGAAGTATGCTGTACCGAGGTGCTGATCTCATC CGGGACGTTGAATTCGTCATTTTTGATGAGGTGCATTATGTGAACGACCTCGAACGAGGAGTGGTATGGGAAGAA GTCATCATTATGCTTCCCGAGCATGTCACGTTGATTCTTCTCTCTGCCACTGTTCCCAATACTCGGGAGTTTGCA TCCTGGGTGGGCCGTACAAAGAAGAAGGACATTTATGTAATTTCAACCCATAAGCGACCTGTCCCGCTGGAGCAC TATCTCTGGGCCGGGAAGAGCAAGCACAAGATCGTCGACTCCAACAAAAGATTCCTTGAGAGTGGCTGGAAGGAA GCGGATGATATCCTGTCCGGCAAAGATAAGGCCAAAGCTAAGAAGGAGGCTGAAGCTCAGGCGCAGTCGGCGCAA GCTAGAGCACCAGCTCCCCAGGGCCGAGGCCGCGGTCAGCCAGCGAATAACAGAGGCGGCCGCGGCGGCCCACAG CGTGGAGGCCCGCAACGAGGTCGAGGACAGAGCGGTGGACAGTACTCCAACCGAGGCACGGGTAACATCGCTCGT ACAGGCCGTGGTGGTGGTCGTACAAGTGCGGCCCAGGACAAAAACACTTGGGTGCATCTTGTTTCGCATCTTCGC AAAGAAGACTTGCTGCCGGGATGTGTCTTCGTTTTCTCTAAGAAACGATGCGAGGAGAACGCAGATTCACTTTCA AACCAAGACTTCAGCAATGCCAACGAGAAGAGTTTGACACACATGTTCATTGAAAAGTCACTCACTCGATTAAAG CCCGAGGACCGTACGCTGCCGCAAATCCTTCGCCTGCGCGAGCTATTAAGCAGAGGCATTGCTGTACACCATGGT GGTCTCCTGCCCATCATGAAGGAAGTTGTTGAGATTCTCTTCGCTAGGTCTCTGGTCAAGGTTCTGTTCGCCACA GAGACCTTCGCGATGGGCTTGAATCTTCCCACCCGAACTGTGGTATTCTCCGGGTTCCGCAAGCACGACGGCAAA AGCTTCCGTGATCTCCTGCCCGGCGAATATACGCAAATGGCTGGACGTGCTGGTCGTAGAGGTCTTGACACGGTG GGATATGTCATCGTGACAAACAGTGGAAAAGACGAGGCCCCATCTGCTGCCTCGTTGAAACAGATGATTCTTGGA GATCCGACAAAGCTCAGATCTCAATTCCGACTCACATACAACATGATACTAAATCTGTTGCGTGTGGAAGCCCTG AAGATCGAGGAAATGATCAAGCGGAGTTTCAGTGAAAACGCAACACAAGCCCTCTTACCAGAACACGAGAAGCAA GTCCAGGTATCTGAGGCCAGTCTTGCGAAAATCAAACGGGCACCATGTGAGATCTGTGATTTGGATCTATTGACC TGCCATAACGCCGCCATGGAGTATCGAAAGCTCACAGCTGAGTTCCACACCGAACTGCTATCATCGCCTGTCGGC AAACGTCTTTTCACAATGAAGAGGTTGGTTGTGTACCGCAAGGATGGACTCCGTACTGCTGGTGTTATTACGCGC GACGGAGTTTCTCCCGGAGTCATTGGGGCCGTGCCCTGTATTCAAGTACTTGAGATTGGAACCTTGAGTAGCAAG CGGCACCCCACTGACATTCTTCCATTCTTACCTTTATTCAGACCCTACTTCCAACCACTCCCCAATCGTGTAGAT GACATGAGCCTTCGAGTGTGCAAGATTCCGTTATCCGATCTCGAGTGCGTGACAAACACCCAGGTTAAAATCACA AAACCAATGTGGTATCTGAATATTAAGAAGGAGTCTATGAAGTGGGCAGAAACAGAACTATGCCAGTTCACCAAC TCTTGGATCGATACGGCCTGGGACGAGATCGACTGGCAACGTATCAAAGAAATGGAAATCCGCGATATCCTCGAC AAACGACAAGTTCAGGCAGAGATTGCCCAGTCATGCCACTGTCTACAATGTCCTGATTTCGTAAACCATTTCGAA ATGCAACACGACGAGTGGCAAGTTAAAGAAAACATCTCGGAGTTGAAGCAGCTGATGTCCGACCAAAACCTCCAA CTACTTCCGGATTATGAGCAGCGCATTCACGTACTGAGGGAGCTCGGCTTTGTTGACGAACAATCTCGTGTACAA CTGAAGGGCAAGGTGGCATGCGAAATTCACTCCGCCGACGAGTTGGTCTTAACCGAATTGGTTCTCGAGAACGTT CTTGCTGAATACGAGCCGGAGGAGATTGTTGCACTCCTCTCTGCATTTGTGTTCCAGGAAAAGACAGACAGCACT CCCACCCTCACTCCACGTCTGGAGAAGGGCCAGAAGGAGATCATTCGTATCGCCGAGAAAGTGAATGATTTCCAG ATTCTGCACCAGGTCATTCAATCTAGTGAAGATTCCAACGACTTCGCTAGTAAGCCACGCTTCGGTCTCGCTGAA GTTGTTTATGAGTGGGCCAAGGGAATGTCTTTCAATCGCATCACTGACCTCACGGACGTAATGGAGGGTACTATT GTTCGGGTGATCACCCGACTGGACGAGACTTGTCGCGAAGTGAAGAATGCGGCCAAACTGGTCGGAGACCCGACA CTTTACACTAAGATGCAGCAAGCTCAGGAGTTGATCAAGCGCGATGTCATCTTCGCGGCCTCTCTTTACATGTGA
Gene	>Pro_DTO377G3_2|g8558.t1 ATGGCCGACTCGCTCGATTCCACAATGAAGGAGCTAGACATAGAAGGCAGACACTTCGACCCCGCGACCTTCGAT GCTCGTCTCGCAGACGAAGAGGATGGCAAGATCGAGAACTTCCAAGCTCGGAAGCAGGCCCCTCAGAGTGCGCAA GAGTTGCTAACAGAGCTCGAAAATGAGTTTCTGACCCCATCGGACCAATTCAGCACTAAATGGTTGAACTCTCTC CAAAAGTAAGTAAGTATCTTGGTTTCATTCGCGGGGCAGCTTTTAACGGCTTTGGCAGACGATGGGACGTTTCGA CAGACTATGCAGACCTTTTCGAACTCGCGCCAACACAAACACGGACAGTAACGCGATTTACACGAGAGGGACTGG AAGGACGCGTCACTGGATATCAAGAAGTCACGGTTCCTGCTGCAAGCGCAACGGCCAAGAATTCCACCTCGCTTC TCCGCCGACCTGCTGGTCGTGCCGACTTTGTCAGAGGTGCCGCAGGTTTCTTTCCGTTCGCACCCGGAGGCTTGG ACGCTATCGAGGCCTTGGCAGCAATGGAGGCCGATGCTCAGGTCACAGAACAATCGACCAAGGGGAAACAATCTG GACTCGATCGCATCATCAACTTTGGCACCGAGGGAGGTCTTCTGACAACACCCCCTGGCTTCGATAACGGTATCG ATTTCGATGAAGCAAAATCTAAAGCCGCCACCGAAGGTGCCCAAGAAGTCGAAACCGCCCTTCTCCAAGAGGAAA GTGACCTGAAGGTGGATCAACCCGAGGAATCTGCGGATGTCGAATTAGGAGCAGAGGTCGAGCTTGATGATATCA GCGACGATGAAGAAGAAGAAGATATTGACGCTTTGCTACCAGTTGAGTTCCCGGCGTTGGAGCCGCGTAGCCAGT TGCTTGCAGGTGTCAAGCAAAAAGGTAGAGAATGGGCCCACGTTGTCGATGTCAACAAGGATATTCCCAACTTCA ATGAGTTGGTTCCAGATATGGCCAGAGAGTGGCCATTCGAGCTCGACACTTTCCAAAAGGAGGCTGTTTACCACC TCGAAAATGGCGATTCGGTGTTTGTTGCAGCCCATACCTCGGCAGGCAAGACAGTTGTGGCTGAATATGCAATCG CCTTGGCTGCTAAGCATATGACCAAAGCAATCTATACTTCTCCCATCAAAGCGCTGAGCAACCAGAAATACCGTG ATTTCAGAACCGAATTCGACGATGTCGGCATTCTGACTGGTGATGTTCAAATCAACCCGGAAGCGAGCTGTCTCA TTATGACCACTGAGATCTTGCGAAGTATGCTGTACCGAGGTGCTGATCTCATCCGGGACGTTGAATTCGTCATTT TTGATGAGGTGCATTATGTGAACGACCTCGAACGAGGAGTGGTATGGGAAGAAGTCATCATTATGCTTCCCGAGC ATGTCACGTTGATTCTTCTCTCTGCCACTGTTCCCAATACTCGGGAGTTTGCATCCTGGGTGGGCCGTACAAAGA AGAAGGACATTTATGTAATTTCAACCCATAAGCGACCTGTCCCGCTGGAGCACTATCTCTGGGCCGGGAAGAGCA AGCACAAGATCGTCGACTCCAACAAAAGATTCCTTGAGAGTGGCTGGAAGGAAGCGGATGATATCCTGTCCGGCA AAGATAAGGCCAAAGCTAAGAAGGAGGCTGAAGCTCAGGCGCAGTCGGCGCAAGCTAGAGCACCAGCTCCCCAGG GCCGAGGCCGCGGTCAGCCAGCGAATAACAGAGGCGGCCGCGGCGGCCCACAGCGTGGAGGCCCGCAACGAGGTC GAGGACAGAGCGGTGGACAGTACTCCAACCGAGGCACGGGTAACATCGCTCGTACAGGCCGTGGTGGTGGTCGTA CAAGTGCGGCCCAGGACAAAAACACTTGGGTGCATCTTGTTTCGCATCTTCGCAAAGAAGACTTGCTGCCGGGAT GTGTCTTCGTTTTCTCTAAGAAACGATGCGAGGAGAACGCAGATTCACTTTCAAACCAAGACTTCAGCAATGCCA ACGAGAAGAGTTTGACACACATGTTCATTGAAAAGTCACTCACTCGATTAAAGCCCGAGGACCGTACGCTGCCGC AAATCCTTCGCCTGCGCGAGCTATTAAGCAGAGGCATTGCTGTACACCATGGTGGTCTCCTGCCCATCATGAAGG AAGTTGTTGAGATTCTCTTCGCTAGGTCTCTGGTCAAGGTTCTGTTCGCCACAGAGACCTTCGCGATGGGCTTGA ATCTTCCCACCCGAACTGTGGTATTCTCCGGGTTCCGCAAGCACGACGGCAAAAGCTTCCGTGATCTCCTGCCCG GCGAATATACGCAAATGGCTGGACGTGCTGGTCGTAGAGGTCTTGACACGGTGGGATATGTCATCGTGACAAACA GTGGAAAAGACGAGGCCCCATCTGCTGCCTCGTTGAAACAGATGATTCTTGGAGATCCGACAAAGCTCAGATCTC AATTCCGACTCACATACAACATGATACTAAATCTGTTGCGTGTGGAAGCCCTGAAGATCGAGGAAATGATCAAGC GGAGTTTCAGTGAAAACGCAACACAAGCCCTCTTACCAGAACACGAGAAGCAAGTCCAGGTATCTGAGGCCAGTC TTGCGAAAATCAAACGGGCACCATGTGAGATCTGTGATTTGGATCTATTGACCTGCCATAACGCCGCCATGGAGT ATCGAAAGCTCACAGCTGAGTTCCACACCGAACTGCTATCATCGCCTGTCGGCAAACGTCTTTTCACAATGAAGA GGTTGGTTGTGTACCGCAAGGTGAGTGCTCGTGTTCTGTTGCGATATAATACATATTTGGTTTAAAGCTAACGTG AAACACAGGATGGACTCCGTACTGCTGGTGTTATTACGCGCGACGGAGTTTCTCCCGGAGTCATTGGGGCCGTGC CCTGTATTCAAGTACTTGAGATTGGAACCTTGAGTAGCAAGCGGCACCCCACTGACATTCTTCCATTCTTACCTT TATTCAGACCCTACTTCCAACCACTCCCCAATCGTGTAGATGACATGAGCCTTCGAGTGTGCAAGATTCCGTTAT CCGATCTCGAGTGCGTGACAAACACCCAGGTTAAAATCACAAAACCAATGTGGTATCTGAATATTAAGAAGGGTA AGTTCATACTGTCTTCTTGAACATACGGTTACGAAAATACTAATTCAGAAATAGAGTCTATGAAGTGGGCAGAAA CAGAACTATGCCAGTTCACCAACTCTTGGATCGATACGGCCTGGGACGAGATCGACTGGCAACGTATCAAAGAAA TGGAAATCCGCGATATCCTCGACAAACGACAAGTTCAGGCAGAGATTGCCCAGTCATGCCACTGTCTACAATGTC CTGATTTCGTAAACCATGTGAGTATCTCATTCCTATTGATCTGAACCCCATACTAATGCCATATAGTTCGAAATG CAACACGACGAGTGGCAAGTTAAAGAAAACATCTCGGAGTTGAAGCAGCTGATGTCCGACCAAAACCTCCAACTA CTTCCGGATTATGAGCAGCGCATTCACGTACTGAGGGAGCTCGGCTTTGTTGACGAACAATCTCGTGTACAACTG AAGGGCAAGGTGGCATGCGAAATTCACTCCGCCGACGAGTTGGTCTTAACCGAATTGGTTCTCGAGAACGTTCTT GCTGAATACGAGCCGGAGGAGATTGTTGCACTCCTCTCTGCATTTGTGTTCCAGGAAAAGACAGACAGCACTCCC ACCCTCACTCCACGTCTGGAGAAGGGCCAGAAGGAGATCATTCGTATCGCCGAGAAAGTGAATGATTTCCAGATT CTGCACCAGGTCATTCAATCTAGTGAAGATTCCAACGACTTCGCTAGTAAGCCACGCTTCGGTCTCGCTGAAGTT GTTTATGAGTGGGCCAAGGGAATGTCTTTCAATCGCATCACTGACCTCACGGACGTAATGGAGGGTACTATTGTT CGGGTGATCACCCGACTGGACGAGACTTGTCGCGAAGTGAAGAATGCGGCCAAACTGGTCGGAGACCCGACACTT TACACTAAGATGCAGCAAGCTCAGGAGTTGATCAAGCGCGATGTCATCTTCGCGGCCTCTCTTTACATGTGA