Fungal Genomics

Agaricus bisporus var bisporus H39 Agaricus bisporus var bisporus H97 Agaricus bisporus var burnettii H119p4 Aspergillus niger CBS 112.32 Aspergillus niger CBS 113.50 Aspergillus niger CBS 115988 Aspergillus niger CBS 115989 Aspergillus niger CBS 118.52 Aspergillus niger CBS 124.48 Aspergillus niger CBS 131.52 Aspergillus niger CBS 133816 Aspergillus niger CBS 147320 Aspergillus niger CBS 147321 Aspergillus niger CBS 147322 Aspergillus niger CBS 147323 Aspergillus niger CBS 147324 Aspergillus niger CBS 147343 Aspergillus niger CBS 147344 Aspergillus niger CBS 147345 Aspergillus niger CBS 147346 Aspergillus niger CBS 147347 Aspergillus niger CBS 147352 Aspergillus niger CBS 147353 Aspergillus niger CBS 147371 Aspergillus niger CBS 147482 Aspergillus niger CBS 630.78 Aspergillus niger CBS 769.97 Niveomyces coronatus CBS 149186 Ophiocordyceps australis 1348a (Ghana) Ophiocordyceps australis map64 (Brazil) Ophiocordyceps camponoti-floridani Ophiocordyceps camponoti-rufipedis Ophiocordyceps kimflemingae Ophiocordyceps subramaniannii Penicillium roqueforti DTO002I6 Penicillium roqueforti DTO003C3 Penicillium roqueforti DTO003H1 (CBS 147308) Penicillium roqueforti DTO006G1 Penicillium roqueforti DTO006G7 Penicillium roqueforti DTO012A1 Penicillium roqueforti DTO012A2 (CBS 147309) Penicillium roqueforti DTO012A6 (CBS 147310) Penicillium roqueforti DTO012A7 Penicillium roqueforti DTO012A8 Penicillium roqueforti DTO012A9 Penicillium roqueforti DTO013E5 Penicillium roqueforti DTO013F2 Penicillium roqueforti DTO013F5 (CBS 147311) Penicillium roqueforti DTO027I6 Penicillium roqueforti DTO032C6 Penicillium roqueforti DTO039G3 Penicillium roqueforti DTO046C5 Penicillium roqueforti DTO070G2 (CBS 147317) Penicillium roqueforti DTO081F9 (CBS 147318) Penicillium roqueforti DTO101D6 (CBS 147325) Penicillium roqueforti DTO102I9 (CBS 147326) Penicillium roqueforti DTO126G2 (CBS 147330) Penicillium roqueforti DTO127F7 (CBS 147331) Penicillium roqueforti DTO127F9 (CBS 147332) Penicillium roqueforti DTO130C1 (CBS 147333) Penicillium roqueforti DTO163C3 (CBS 147337) Penicillium roqueforti DTO163F5 (CBS 147338) Penicillium roqueforti DTO163G4 (CBS 147339) Penicillium roqueforti DTO265D5 (CBS 147372) Penicillium roqueforti DTO369A1 (CBS 147354) Penicillium roqueforti DTO375B1 (CBS 147355) Penicillium roqueforti DTO377G2 (LCP 96.3914a) Penicillium roqueforti LCP96 04111 Rhodonia placenta FPRL280 Torrubiellomyces zombiae CBS 149187

General Properties

Protein ID	Pro_DTO377G3_2|g8552.t1
Gene name
Location	scaffold_34:131175..134917
Strand	-
Gene length (bp)	3742
Transcript length (bp)	3507
Coding sequence length (bp)	3507
Protein length (aa)	1169

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PFAM Domains

PFAM Domain ID	Short name	Long name	E-value	Start	End
PF02786	CPSase_L_D2	Carbamoyl-phosphate synthase L chain, ATP binding domain	2.1E-84	213	416
PF02786	CPSase_L_D2	Carbamoyl-phosphate synthase L chain, ATP binding domain	3.0E-20	750	954
PF02787	CPSase_L_D3	Carbamoyl-phosphate synthetase large chain, oligomerisation domain	3.4E-27	501	581
PF07478	Dala_Dala_lig_C	D-ala D-ala ligase C-terminus	7.8E-08	238	383
PF07478	Dala_Dala_lig_C	D-ala D-ala ligase C-terminus	5.9E-07	765	900
PF02222	ATP-grasp	ATP-grasp domain	2.1E-07	222	373

GO

GO Term	Description	Terminal node
GO:0008716	D-alanine-D-alanine ligase activity	Yes
GO:0005524	ATP binding	Yes
GO:0005488	binding	No
GO:0032553	ribonucleotide binding	No
GO:0035639	purine ribonucleoside triphosphate binding	No
GO:0032559	adenyl ribonucleotide binding	No
GO:0016879	ligase activity, forming carbon-nitrogen bonds	No
GO:0043167	ion binding	No
GO:0016881	acid-amino acid ligase activity	No
GO:0017076	purine nucleotide binding	No
GO:0097367	carbohydrate derivative binding	No
GO:0030554	adenyl nucleotide binding	No
GO:0000166	nucleotide binding	No
GO:0003824	catalytic activity	No
GO:0036094	small molecule binding	No
GO:0003674	molecular_function	No
GO:0016874	ligase activity	No
GO:0097159	organic cyclic compound binding	No
GO:0032555	purine ribonucleotide binding	No
GO:1901363	heterocyclic compound binding	No
GO:0043168	anion binding	No
GO:1901265	nucleoside phosphate binding	No

SignalP

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SignalP signal predicted	Location (based on Ymax)	D score (significance: > 0.45)
No	1 - 21	0.45

Transmembrane Domains

(None)

Transcription Factor Class

(None)

Expression data

Analysis 1: Genome-wide gene expression in conidia of Penicillium roqueforti during growth at various temperatures and for various amounts of time. Published in Punt et al., 2020.

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Sequences

Type of sequence	Sequence
Locus	Download genbank file of locus The gene with 5 kb flanks (if sufficient flanking sequence is available). For use in cloning design programs. NOTE: features (genes or exons) that are only partially contained within the sequence are completely excluded.
Protein	>Pro_DTO377G3_2|g8552.t1 MALAARCGQAAALLRQRCIAETRPALSLRAFSSQSVRSTASTLRLQKIPTARSQQLRSFSSTLNRLAAERPPAAE SYLASGAVSAGSNLVDVKKVLVIGSGGLSIGQAGEFDYSGSQALKALKEAGVHSILINPNIATIQTDHKLADEVY YLPVTPEYVTHVIERERPDGILLTFGGQTALNLGVQMNRMGTFERYGVKVLGTPIKTLETSEDRDLFAQALNEID IPIAESTAVETVEDALKAAEQVGYPIIVRSAYALGGLGSGFANNPDELRDLSSRSLSLSPQILVEKSLKGWKEVE YEVVRDAANNCITVCNMENFDPLGIHTGDSIVVAPSQTLSDEEYHMLRTAAIKIVRHLGVVGECNVQYALQPDGL DYRVIEVNARLSRSSALASKATGYPLAYTAAKIGLGHTLPELPNAVTKTTTANFEPSLDYVVTKIPRWDLSKFQH VNRDIGSAMKSVGEVMAIGRTWEESLQKAIRQVDPQYLGLQGDKFDDLDETLRNPTDRRWLAVGQAMLHENYSVD KVHELTKIDKWFLYKIQNIVDCNNELKEIGSLFGLKQEILMKAKKLGFSDKQISLLVGSTEDDVRARRKSFGITP WVKKIDTLAAEFPADTNYLYTTYNASSHDVTFDDHGIIILGSGVYRIGSSVEFDWCAVNATLSLREMGKKTVMIN YNPETYSTDFDTADKLYFEELSYERVMDIYELEASSGVVVSVGGQLPQNIALRLQESGGATIMGTNPLDIDKAED RHKFSSILDSIGVDQPAWKELTSVADAEVFADTVGYPVLVRPSYVLSGAAMNVIYGVDELKEKLLNAAAVSPDHP VVITKFIEGAEEIDVDAVASNGKLLVHAVSEHVEPAGVHSGDATLVLPPATLEEPIMARVKEIAEKVAKAWNITG PFNMQIIKADQEGGEPALKVIECNLRASRSFPFVSKVLGTNFIDVATKALVGRDVPEPVDLMKVKRDYLATKVPQ FSWTRLAGADPFLGVEMSSTGEIACFGKDLIEAYWSSLQSTMNFRVPEPGEGILLGGDTNQPYLTRIVDYLHPLG YKFYAVNPEVKAHIESTAQNDVSVKLIEFPKKDKRALREVFQKYDIRGCFNLAKTRGKTQLDEDYVMRRNAVDFS VPLFMEPKTAQLFAQCMSQKLPRAEGIPSEVRTWANFVGGKAL*
Coding	>Pro_DTO377G3_2|g8552.t1 ATGGCTCTCGCTGCTCGATGTGGGCAGGCGGCCGCTCTGCTGCGCCAGCGCTGCATTGCTGAAACCCGACCAGCA CTTTCTCTGCGCGCATTCTCATCTCAGTCCGTCCGTTCAACGGCCTCCACACTACGCCTGCAGAAGATCCCCACG GCTCGGTCTCAGCAGCTCCGTTCTTTCTCTAGCACATTGAACCGCCTGGCTGCTGAGAGGCCCCCGGCTGCTGAG TCTTATCTCGCTAGCGGTGCTGTGTCGGCAGGTAGCAACCTCGTCGATGTCAAGAAGGTCCTCGTCATTGGCAGT GGTGGTTTGAGCATTGGACAAGCTGGAGAATTCGATTATTCTGGCTCTCAAGCACTCAAGGCTCTCAAGGAAGCT GGCGTCCACTCGATCCTGATCAACCCCAACATTGCGACCATCCAGACCGACCACAAGCTTGCGGACGAAGTCTAC TACCTCCCCGTCACCCCCGAATATGTTACCCACGTCATTGAGCGCGAGCGCCCCGATGGTATTCTCCTCACCTTC GGTGGTCAGACTGCCCTGAACCTGGGTGTGCAGATGAACCGCATGGGCACCTTTGAACGCTACGGTGTCAAGGTT CTCGGCACCCCCATCAAGACCCTGGAGACTAGTGAGGACCGTGACCTCTTCGCCCAGGCCTTGAACGAGATCGAT ATTCCCATTGCTGAATCGACCGCTGTCGAGACTGTCGAGGACGCTCTCAAGGCTGCCGAGCAGGTTGGATACCCC ATCATTGTTCGGTCTGCTTACGCCCTCGGTGGCCTGGGTTCTGGCTTCGCCAACAACCCCGATGAGCTCCGTGAC TTGTCCTCGCGCTCTCTGTCTCTGTCTCCCCAGATTCTGGTCGAGAAGTCCCTTAAGGGCTGGAAGGAGGTTGAG TACGAGGTTGTCCGTGACGCTGCCAACAACTGTATTACCGTTTGCAACATGGAGAACTTCGACCCTCTCGGAATT CATACCGGTGACAGTATCGTTGTTGCCCCTAGTCAGACTCTGTCTGATGAGGAGTACCACATGCTCCGCACTGCT GCTATTAAGATTGTCCGTCACTTGGGTGTCGTTGGCGAGTGCAATGTCCAATACGCTCTGCAGCCCGATGGACTC GACTACCGTGTCATTGAGGTTAACGCTCGTCTTTCGCGTTCCTCCGCCCTGGCTTCCAAGGCCACCGGTTACCCG CTTGCTTATACCGCGGCTAAGATCGGGTTGGGACATACTCTTCCCGAGCTCCCTAATGCCGTTACTAAGACCACC ACTGCCAACTTCGAGCCCAGTCTGGACTATGTTGTCACCAAGATTCCCCGCTGGGATTTGAGCAAGTTCCAGCAC GTTAACCGCGACATTGGCTCCGCCATGAAGTCGGTCGGCGAGGTTATGGCTATTGGCCGTACCTGGGAGGAGTCC CTGCAGAAGGCCATCCGTCAGGTTGACCCTCAATACCTTGGTCTCCAGGGTGATAAGTTTGATGACCTTGACGAG ACTCTCCGCAACCCCACTGATCGCCGCTGGTTGGCTGTTGGCCAGGCTATGCTCCACGAGAACTACTCCGTTGAC AAGGTTCACGAGCTGACAAAGATCGACAAGTGGTTCTTGTACAAGATCCAGAACATTGTGGATTGCAACAATGAA CTCAAGGAAATCGGCAGCCTCTTCGGCCTCAAGCAGGAGATCCTGATGAAGGCTAAGAAGCTCGGTTTCTCCGAT AAGCAGATCTCTCTCCTGGTTGGATCTACCGAGGATGATGTCCGTGCTCGCCGTAAGTCCTTCGGCATCACTCCT TGGGTTAAGAAGATCGATACCCTTGCTGCCGAGTTCCCCGCCGATACCAACTACCTCTACACTACCTATAACGCT TCCTCCCACGATGTTACCTTCGATGACCACGGAATTATCATTCTTGGCAGCGGTGTGTACCGTATTGGTAGCTCC GTTGAGTTCGATTGGTGCGCTGTTAACGCTACTCTCTCCCTCCGTGAGATGGGCAAGAAGACCGTTATGATTAAC TACAACCCCGAGACCTACTCCACTGACTTCGATACCGCTGATAAGCTGTACTTCGAGGAGCTCAGCTACGAGCGT GTCATGGATATCTACGAGCTCGAGGCGTCTAGCGGTGTCGTTGTCTCTGTCGGTGGTCAGCTTCCTCAGAACATT GCCCTCCGCCTGCAAGAGAGCGGTGGTGCTACTATTATGGGTACCAACCCTCTGGACATTGACAAGGCCGAGGAC CGTCACAAGTTCTCCTCTATCCTCGATAGCATTGGTGTTGACCAGCCCGCCTGGAAGGAACTGACCTCTGTCGCT GATGCTGAGGTCTTCGCCGACACTGTGGGTTACCCCGTCTTGGTTCGTCCCAGTTACGTTCTGTCCGGTGCCGCC ATGAACGTCATCTACGGTGTCGATGAGCTCAAGGAGAAGCTCTTGAACGCCGCTGCCGTTTCCCCTGATCACCCC GTTGTCATCACCAAGTTCATCGAGGGTGCCGAGGAGATTGATGTGGATGCCGTCGCTTCCAACGGTAAGCTGCTT GTCCACGCTGTTTCCGAGCACGTCGAGCCCGCTGGTGTTCACTCCGGTGATGCCACCCTCGTCCTGCCCCCCGCT ACCCTTGAGGAGCCCATCATGGCCCGCGTCAAGGAGATCGCCGAAAAGGTCGCTAAGGCCTGGAACATTACTGGC CCCTTCAACATGCAGATCATCAAGGCCGACCAGGAGGGTGGCGAGCCCGCGCTCAAGGTTATTGAGTGCAACCTG CGCGCCTCTCGCTCCTTCCCCTTCGTCAGCAAGGTCCTAGGTACCAACTTCATCGACGTCGCCACCAAGGCTCTC GTCGGCCGTGATGTCCCCGAGCCCGTCGACCTCATGAAGGTGAAGCGTGACTACCTCGCTACCAAGGTTCCCCAG TTCTCCTGGACCCGTCTGGCTGGTGCCGACCCCTTCCTGGGCGTCGAGATGTCCTCCACCGGTGAAATTGCTTGC TTCGGTAAGGATCTGATCGAGGCATACTGGTCTTCCCTCCAGTCCACCATGAACTTCCGCGTGCCCGAGCCCGGC GAGGGTATCTTGCTCGGCGGTGATACCAACCAGCCCTACCTGACCAGGATTGTCGACTACCTGCACCCTCTTGGC TACAAGTTCTATGCCGTCAACCCCGAAGTCAAGGCTCACATCGAGTCCACCGCCCAGAATGACGTCTCCGTGAAG CTGATTGAGTTCCCCAAGAAGGACAAGCGTGCTCTCCGTGAAGTGTTCCAGAAGTACGACATCCGTGGCTGCTTC AACCTTGCCAAGACCCGTGGCAAGACCCAGCTTGATGAAGACTATGTCATGCGTCGCAACGCTGTCGATTTCAGC GTGCCTCTATTCATGGAGCCTAAGACTGCCCAGCTCTTTGCTCAGTGCATGAGCCAGAAGCTGCCCCGCGCCGAA GGAATTCCCTCCGAGGTCCGCACCTGGGCCAACTTTGTCGGCGGCAAGGCACTGTAA
Transcript	>Pro_DTO377G3_2|g8552.t1 ATGGCTCTCGCTGCTCGATGTGGGCAGGCGGCCGCTCTGCTGCGCCAGCGCTGCATTGCTGAAACCCGACCAGCA CTTTCTCTGCGCGCATTCTCATCTCAGTCCGTCCGTTCAACGGCCTCCACACTACGCCTGCAGAAGATCCCCACG GCTCGGTCTCAGCAGCTCCGTTCTTTCTCTAGCACATTGAACCGCCTGGCTGCTGAGAGGCCCCCGGCTGCTGAG TCTTATCTCGCTAGCGGTGCTGTGTCGGCAGGTAGCAACCTCGTCGATGTCAAGAAGGTCCTCGTCATTGGCAGT GGTGGTTTGAGCATTGGACAAGCTGGAGAATTCGATTATTCTGGCTCTCAAGCACTCAAGGCTCTCAAGGAAGCT GGCGTCCACTCGATCCTGATCAACCCCAACATTGCGACCATCCAGACCGACCACAAGCTTGCGGACGAAGTCTAC TACCTCCCCGTCACCCCCGAATATGTTACCCACGTCATTGAGCGCGAGCGCCCCGATGGTATTCTCCTCACCTTC GGTGGTCAGACTGCCCTGAACCTGGGTGTGCAGATGAACCGCATGGGCACCTTTGAACGCTACGGTGTCAAGGTT CTCGGCACCCCCATCAAGACCCTGGAGACTAGTGAGGACCGTGACCTCTTCGCCCAGGCCTTGAACGAGATCGAT ATTCCCATTGCTGAATCGACCGCTGTCGAGACTGTCGAGGACGCTCTCAAGGCTGCCGAGCAGGTTGGATACCCC ATCATTGTTCGGTCTGCTTACGCCCTCGGTGGCCTGGGTTCTGGCTTCGCCAACAACCCCGATGAGCTCCGTGAC TTGTCCTCGCGCTCTCTGTCTCTGTCTCCCCAGATTCTGGTCGAGAAGTCCCTTAAGGGCTGGAAGGAGGTTGAG TACGAGGTTGTCCGTGACGCTGCCAACAACTGTATTACCGTTTGCAACATGGAGAACTTCGACCCTCTCGGAATT CATACCGGTGACAGTATCGTTGTTGCCCCTAGTCAGACTCTGTCTGATGAGGAGTACCACATGCTCCGCACTGCT GCTATTAAGATTGTCCGTCACTTGGGTGTCGTTGGCGAGTGCAATGTCCAATACGCTCTGCAGCCCGATGGACTC GACTACCGTGTCATTGAGGTTAACGCTCGTCTTTCGCGTTCCTCCGCCCTGGCTTCCAAGGCCACCGGTTACCCG CTTGCTTATACCGCGGCTAAGATCGGGTTGGGACATACTCTTCCCGAGCTCCCTAATGCCGTTACTAAGACCACC ACTGCCAACTTCGAGCCCAGTCTGGACTATGTTGTCACCAAGATTCCCCGCTGGGATTTGAGCAAGTTCCAGCAC GTTAACCGCGACATTGGCTCCGCCATGAAGTCGGTCGGCGAGGTTATGGCTATTGGCCGTACCTGGGAGGAGTCC CTGCAGAAGGCCATCCGTCAGGTTGACCCTCAATACCTTGGTCTCCAGGGTGATAAGTTTGATGACCTTGACGAG ACTCTCCGCAACCCCACTGATCGCCGCTGGTTGGCTGTTGGCCAGGCTATGCTCCACGAGAACTACTCCGTTGAC AAGGTTCACGAGCTGACAAAGATCGACAAGTGGTTCTTGTACAAGATCCAGAACATTGTGGATTGCAACAATGAA CTCAAGGAAATCGGCAGCCTCTTCGGCCTCAAGCAGGAGATCCTGATGAAGGCTAAGAAGCTCGGTTTCTCCGAT AAGCAGATCTCTCTCCTGGTTGGATCTACCGAGGATGATGTCCGTGCTCGCCGTAAGTCCTTCGGCATCACTCCT TGGGTTAAGAAGATCGATACCCTTGCTGCCGAGTTCCCCGCCGATACCAACTACCTCTACACTACCTATAACGCT TCCTCCCACGATGTTACCTTCGATGACCACGGAATTATCATTCTTGGCAGCGGTGTGTACCGTATTGGTAGCTCC GTTGAGTTCGATTGGTGCGCTGTTAACGCTACTCTCTCCCTCCGTGAGATGGGCAAGAAGACCGTTATGATTAAC TACAACCCCGAGACCTACTCCACTGACTTCGATACCGCTGATAAGCTGTACTTCGAGGAGCTCAGCTACGAGCGT GTCATGGATATCTACGAGCTCGAGGCGTCTAGCGGTGTCGTTGTCTCTGTCGGTGGTCAGCTTCCTCAGAACATT GCCCTCCGCCTGCAAGAGAGCGGTGGTGCTACTATTATGGGTACCAACCCTCTGGACATTGACAAGGCCGAGGAC CGTCACAAGTTCTCCTCTATCCTCGATAGCATTGGTGTTGACCAGCCCGCCTGGAAGGAACTGACCTCTGTCGCT GATGCTGAGGTCTTCGCCGACACTGTGGGTTACCCCGTCTTGGTTCGTCCCAGTTACGTTCTGTCCGGTGCCGCC ATGAACGTCATCTACGGTGTCGATGAGCTCAAGGAGAAGCTCTTGAACGCCGCTGCCGTTTCCCCTGATCACCCC GTTGTCATCACCAAGTTCATCGAGGGTGCCGAGGAGATTGATGTGGATGCCGTCGCTTCCAACGGTAAGCTGCTT GTCCACGCTGTTTCCGAGCACGTCGAGCCCGCTGGTGTTCACTCCGGTGATGCCACCCTCGTCCTGCCCCCCGCT ACCCTTGAGGAGCCCATCATGGCCCGCGTCAAGGAGATCGCCGAAAAGGTCGCTAAGGCCTGGAACATTACTGGC CCCTTCAACATGCAGATCATCAAGGCCGACCAGGAGGGTGGCGAGCCCGCGCTCAAGGTTATTGAGTGCAACCTG CGCGCCTCTCGCTCCTTCCCCTTCGTCAGCAAGGTCCTAGGTACCAACTTCATCGACGTCGCCACCAAGGCTCTC GTCGGCCGTGATGTCCCCGAGCCCGTCGACCTCATGAAGGTGAAGCGTGACTACCTCGCTACCAAGGTTCCCCAG TTCTCCTGGACCCGTCTGGCTGGTGCCGACCCCTTCCTGGGCGTCGAGATGTCCTCCACCGGTGAAATTGCTTGC TTCGGTAAGGATCTGATCGAGGCATACTGGTCTTCCCTCCAGTCCACCATGAACTTCCGCGTGCCCGAGCCCGGC GAGGGTATCTTGCTCGGCGGTGATACCAACCAGCCCTACCTGACCAGGATTGTCGACTACCTGCACCCTCTTGGC TACAAGTTCTATGCCGTCAACCCCGAAGTCAAGGCTCACATCGAGTCCACCGCCCAGAATGACGTCTCCGTGAAG CTGATTGAGTTCCCCAAGAAGGACAAGCGTGCTCTCCGTGAAGTGTTCCAGAAGTACGACATCCGTGGCTGCTTC AACCTTGCCAAGACCCGTGGCAAGACCCAGCTTGATGAAGACTATGTCATGCGTCGCAACGCTGTCGATTTCAGC GTGCCTCTATTCATGGAGCCTAAGACTGCCCAGCTCTTTGCTCAGTGCATGAGCCAGAAGCTGCCCCGCGCCGAA GGAATTCCCTCCGAGGTCCGCACCTGGGCCAACTTTGTCGGCGGCAAGGCACTGTAA
Gene	>Pro_DTO377G3_2|g8552.t1 ATGGCTCTCGCTGCTCGATGTGGGCAGGCGGCCGCTCTGCTGCGCCAGCGCTGCATTGCTGAAACCCGACCAGCA CTTTCTCTGCGCGCATTCTCATCTCAGTCCGTCCGTTCAACGGCCTCCACACTACGCCTGCAGAAGATCCCCACG GCTCGGTCTCAGCAGCTCCGTTCTTTCTCTAGCACATTGAACCGCCTGGCTGCTGAGAGGCCCCCGGCTGCTGAG TCTTATCTCGCTAGCGGTGCTGTGTCGGCAGGTAGCAACCTCGTCGATGTCAAGAAGGTCCTCGTCATTGGCAGT GGTGGTTTGAGCATTGGACAAGCTGGAGAATTCGATTATTCTGGTAAGTTGCAATCACTTGGAGATGAAATTTTC GATCACATCGCCCTGTCAGTCCCCATGGGGGTTGCGTCTGCACGAGAAGCTTTTCTGTGGGGAATACAGAGAGCT TGAAAAATGATCGCTAAAAATCAATCTAAATGAGAACTGTAACTAATCTTTTGACTGTGCGATAAAATAGGCTCT CAAGCACTCAAGGCTCTCAAGGAAGCTGGCGTCCACTCGATCCTGATCAACCCCAACATTGCGACCATCCAGACC GACCACAAGCTTGCGGACGAAGTCTACTACCTCCCCGTCACCCCCGAATATGTTACCCACGTCATTGAGCGCGAG CGCCCCGATGGTATTCTCCTCACCTTCGGTGGTCAGACTGCCCTGAACCTGGGTGTGCAGATGAACCGCATGGGC ACCTTTGAACGCTACGGTGTCAAGGTTCTCGGCACCCCCATCAAGACCCTGGAGACTAGTGAGGACCGTGACCTC TTCGCCCAGGCCTTGAACGAGATCGATATTCCCATTGCTGAATCGACCGCTGTCGAGACTGTCGAGGACGCTCTC AAGGCTGCCGAGCAGGTTGGATACCCCATCATTGTTCGGTCTGCTTACGCCCTCGGTGGCCTGGGTTCTGGCTTC GCCAACAACCCCGATGAGCTCCGTGACTTGTCCTCGCGCTCTCTGTCTCTGTCTCCCCAGATTCTGGTCGAGAAG TCCCTTAAGGGCTGGAAGGAGGTTGAGTACGAGGTTGTCCGTGACGCTGCCAACAACTGTATTACCGTTTGCAAC ATGGAGAACTTCGACCCTCTCGGAATTCATACCGGTGACAGTATCGTTGTTGCCCCTAGTCAGACTCTGTCTGAT GAGGAGTACCACATGCTCCGCACTGCTGCTATTAAGATTGTCCGTCACTTGGGTGTCGTTGGCGAGTGCAATGTC CAATACGCTCTGCAGCCCGATGGACTCGACTACCGTGTCATTGAGGTTAACGCTCGTCTTTCGCGTTCCTCCGCC CTGGCTTCCAAGGCCACCGGTTACCCGCTTGCTTATACCGCGGCTAAGATCGGGTTGGGACATACTCTTCCCGAG CTCCCTAATGCCGTTACTAAGACCACCACTGCCAACTTCGAGCCCAGTCTGGACTATGTTGTCACCAAGATTCCC CGCTGGGATTTGAGCAAGTTCCAGCACGTTAACCGCGACATTGGCTCCGCCATGAAGTCGGTCGGCGAGGTTATG GCTATTGGCCGTACCTGGGAGGAGTCCCTGCAGAAGGCCATCCGTCAGGTTGACCCTCAATACCTTGGTCTCCAG GGTGATAAGTTTGATGACCTTGACGAGACTCTCCGCAACCCCACTGATCGCCGCTGGTTGGCTGTTGGCCAGGCT ATGCTCCACGAGAACTACTCCGTTGACAAGGTTCACGAGCTGACAAAGATCGACAAGTGGTTCTTGTACAAGATC CAGAACATTGTGGATTGCAACAATGAACTCAAGGAAATCGGCAGCCTCTTCGGCCTCAAGCAGGAGATCCTGATG AAGGCTAAGAAGCTCGGTTTCTCCGATAAGCAGATCTCTCTCCTGGTTGGATCTACCGAGGATGATGTCCGTGCT CGCCGTAAGTCCTTCGGCATCACTCCTTGGGTTAAGAAGATCGATACCCTTGCTGCCGAGTTCCCCGCCGATACC AACTACCTCTACACTACCTATAACGCTTCCTCCCACGATGTTACCTTCGATGACCACGGAATTATCATTCTTGGC AGCGGTGTGTACCGTATTGGTAGCTCCGTTGAGTTCGATTGGTGCGCTGTTAACGCTACTCTCTCCCTCCGTGAG ATGGGCAAGAAGACCGTTATGATTAACTACAACCCCGAGACCTACTCCACTGACTTCGATACCGCTGATAAGCTG TACTTCGAGGAGCTCAGCTACGAGCGTGTCATGGATATCTACGAGCTCGAGGCGTCTAGCGGTGTCGTTGTCTCT GTCGGTGGTCAGCTTCCTCAGAACATTGCCCTCCGCCTGCAAGAGAGCGGTGGTGCTACTATTATGGGTACCAAC CCTCTGGACATTGACAAGGCCGAGGACCGTCACAAGTTCTCCTCTATCCTCGATAGCATTGGTGTTGACCAGCCC GCCTGGAAGGAACTGACCTCTGTCGCTGATGCTGAGGTCTTCGCCGACACTGTGGGTTACCCCGTCTTGGTTCGT CCCAGTTACGTTCTGTCCGGTGCCGCCATGAACGTCATCTACGGTGTCGATGAGCTCAAGGAGAAGCTCTTGAAC GCCGCTGCCGTTTCCCCTGATCACCCCGTTGTCATCACCAAGTTCATCGAGGGTGCCGAGGAGATTGATGTGGAT GCCGTCGCTTCCAACGGTAAGCTGCTTGTCCACGCTGTTTCCGAGCACGTCGAGCCCGCTGGTGTTCACTCCGGT GATGCCACCCTCGTCCTGCCCCCCGCTACCCTTGAGGAGCCCATCATGGCCCGCGTCAAGGAGATCGCCGAAAAG GTCGCTAAGGCCTGGAACATTACTGGCCCCTTCAACATGCAGATCATCAAGGCCGACCAGGAGGGTGGCGAGCCC GCGCTCAAGGTTATTGAGTGCAACCTGCGCGCCTCTCGCTCCTTCCCCTTCGTCAGCAAGGTCCTAGGTACCAAC TTCATCGACGTCGCCACCAAGGCTCTCGTCGGCCGTGATGTCCCCGAGCCCGTCGACCTCATGAAGGTGAAGCGT GACTACCTCGCTACCAAGGTTCCCCAGTTCTCCTGGACCCGTCTGGCTGGTGCCGACCCCTTCCTGGGCGTCGAG ATGTCCTCCACCGGTGAAATTGCTTGCTTCGGTAAGGATCTGATCGAGGCATACTGGTCTTCCCTCCAGTCCACC ATGAACTTCCGCGTGCCCGAGCCCGGCGAGGGTATCTTGCTCGGCGGTGATACCAACCAGCCCTACCTGACCAGG ATTGTCGACTACCTGCACCCTCTTGGCTACAAGTTCTATGCCGTCAACCCCGAAGTCAAGGCTCACATCGAGTCC ACCGCCCAGAATGACGTCTCCGTGAAGCTGATTGAGTTCCCCAAGAAGGACAAGCGTGCTCTCCGTGAAGTGTTC CAGAAGTACGACATCCGTGGCTGCTTCAACCTTGCCAAGACCCGTGGCAAGACCCAGCTTGATGAAGACTATGTC ATGCGTCGCAACGCTGTCGATTTCAGCGTGCCTCTATTCATGGAGCCTAAGGTATGTTCAAAGAGCTGATACTCC ATAATTATTCAACTTGCTAACTGATCCTCTACAGACTGCCCAGCTCTTTGCTCAGTGCATGAGCCAGAAGCTGCC CCGCGCCGAAGGAATTCCCTCCGAGGTCCGCACCTGGGCCAACTTTGTCGGCGGCAAGGCACTGTAA