Fungal Genomics

Agaricus bisporus var bisporus H39 Agaricus bisporus var bisporus H97 Agaricus bisporus var burnettii H119p4 Aspergillus niger CBS 112.32 Aspergillus niger CBS 113.50 Aspergillus niger CBS 115988 Aspergillus niger CBS 115989 Aspergillus niger CBS 118.52 Aspergillus niger CBS 124.48 Aspergillus niger CBS 131.52 Aspergillus niger CBS 133816 Aspergillus niger CBS 147320 Aspergillus niger CBS 147321 Aspergillus niger CBS 147322 Aspergillus niger CBS 147323 Aspergillus niger CBS 147324 Aspergillus niger CBS 147343 Aspergillus niger CBS 147344 Aspergillus niger CBS 147345 Aspergillus niger CBS 147346 Aspergillus niger CBS 147347 Aspergillus niger CBS 147352 Aspergillus niger CBS 147353 Aspergillus niger CBS 147371 Aspergillus niger CBS 147482 Aspergillus niger CBS 630.78 Aspergillus niger CBS 769.97 Ophiocordyceps australis 1348a (Ghana) Ophiocordyceps australis map64 (Brazil) Ophiocordyceps camponoti-floridani Ophiocordyceps camponoti-rufipedis Ophiocordyceps kimflemingae Ophiocordyceps subramaniannii Penicillium roqueforti DTO002I6 Penicillium roqueforti DTO003C3 Penicillium roqueforti DTO003H1 (CBS 147308) Penicillium roqueforti DTO006G1 Penicillium roqueforti DTO006G7 Penicillium roqueforti DTO012A1 Penicillium roqueforti DTO012A2 (CBS 147309) Penicillium roqueforti DTO012A6 (CBS 147310) Penicillium roqueforti DTO012A7 Penicillium roqueforti DTO012A8 Penicillium roqueforti DTO012A9 Penicillium roqueforti DTO013E5 Penicillium roqueforti DTO013F2 Penicillium roqueforti DTO013F5 (CBS 147311) Penicillium roqueforti DTO027I6 Penicillium roqueforti DTO032C6 Penicillium roqueforti DTO039G3 Penicillium roqueforti DTO046C5 Penicillium roqueforti DTO070G2 (CBS 147317) Penicillium roqueforti DTO081F9 (CBS 147318) Penicillium roqueforti DTO101D6 (CBS 147325) Penicillium roqueforti DTO102I9 (CBS 147326) Penicillium roqueforti DTO126G2 (CBS 147330) Penicillium roqueforti DTO127F7 (CBS 147331) Penicillium roqueforti DTO127F9 (CBS 147332) Penicillium roqueforti DTO130C1 (CBS 147333) Penicillium roqueforti DTO163C3 (CBS 147337) Penicillium roqueforti DTO163F5 (CBS 147338) Penicillium roqueforti DTO163G4 (CBS 147339) Penicillium roqueforti DTO265D5 (CBS 147372) Penicillium roqueforti DTO369A1 (CBS 147354) Penicillium roqueforti DTO375B1 (CBS 147355) Penicillium roqueforti DTO377G2 (LCP 96.3914a) Penicillium roqueforti LCP96 04111 Rhodonia placenta FPRL280

General Properties

Protein ID	Pro_DTO377G3_2|g8525.t1
Gene name
Location	scaffold_34:59431..63157
Strand	+
Gene length (bp)	3726
Transcript length (bp)	3615
Coding sequence length (bp)	3615
Protein length (aa)	1205

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PFAM Domains

PFAM Domain ID	Short name	Long name	E-value	Start	End
PF00018	SH3_1	SH3 domain	3.5E-06	12	59
PF07653	SH3_2	Variant SH3 domain	5.9E-05	8	64

GO

GO Term	Description	Terminal node
GO:0005515	protein binding	Yes
GO:0005488	binding	No
GO:0003674	molecular_function	No

SignalP

[Help with interpreting these statistics]

SignalP signal predicted	Location (based on Ymax)	D score (significance: > 0.45)
No	1 - 18	0.45

Transmembrane Domains

(None)

Transcription Factor Class

(None)

Expression data

Analysis 1: Genome-wide gene expression in conidia of Penicillium roqueforti during growth at various temperatures and for various amounts of time. Published in Punt et al., 2020.

Expression values

Label	Description	Expression (RPKM)	Confidence interval (low)	Confidence interval (high)
3d_25C	Three days - 25 degrees Celsius	48.16	29.37	66.95
5d_25C	Five days - 25 degrees Celsius	62.12	37.64	86.61
7d_25C	Seven days - 25 degrees Celsius	62.27	37.58	86.97
10d_25C	Ten days - 25 degrees Celsius	87.53	52.28	122.77
7d_15C	Seven days - 15 degrees Celsius	56.13	33.79	78.48
7d_30C	Seven days - 30 degrees Celsius	63.31	38.19	88.43

Differential expression

Label1	Label2	Q-value	Significant difference
3d_25C	5d_25C	0.284873	no
3d_25C	7d_25C	0.274292	no
3d_25C	7d_15C	0.564120	no
3d_25C	7d_30C	0.242839	no
3d_25C	10d_25C	0.002761	yes
5d_25C	7d_25C	0.994748	no
5d_25C	7d_15C	0.726036	no
5d_25C	7d_30C	0.957553	no
5d_25C	10d_25C	0.118954	no
7d_25C	7d_15C	0.717430	no
7d_25C	7d_30C	0.963184	no
7d_25C	10d_25C	0.125681	no
7d_15C	7d_30C	0.671222	no
7d_15C	10d_25C	0.038184	yes
7d_30C	10d_25C	0.153388	no

Sequences

Type of sequence	Sequence
Locus	Download genbank file of locus The gene with 5 kb flanks (if sufficient flanking sequence is available). For use in cloning design programs. NOTE: features (genes or exons) that are only partially contained within the sequence are completely excluded.
Protein	>Pro_DTO377G3_2|g8525.t1 MSVPPFTVRSVFEYASGHDDDLNFPIGQIVTVTALEDDDWYYGEYSDAQGARQEGIFPKNFVEKYEPPAPPRPSR PRPKKEPETLPVESPVVESKQAEREPEPAVQPTEEDYGIQSSQPLPQSPRLHASAPVSEVVSSPPQPAKAPAPAH PVAPTESAAKAPSKPAPPAVADKPSGSSFRDRIAAFNKPAAAPVTPFKPGGSQPSFVKKPFVAPPPSRDAYKPPP REPAPKIYKREEDPDVKEQIAREPPVSESRPAHIEGGEEGAEDQPKPTSLKDRIALLQKQQLEQAQRHAEAAQKK EKPSRPPKKSMDEPVAPAVLDEEQEPPSVEEPPATRDTSVDTLRAAAPPSQPPAPFSPTQEVASDANDADYSAAA DSEDAGETSTSKDDEEDQAQPRPVSRRQPLTPAVEQTAEADVEDEGDAEEEEEEEMDPETKRRMELRERMAKMSG GMGMMGLFGPPIGGMPGMPGMASAGSARKPKTPIESEKRLGELESEPTSPANAPPVPMIPLPGMNAASKPVPSYT EVEKEEEEPLATPLTEQHPARDVPDVEEVVHEGALPRTSIDRPAPAPPSQDRSAPPPPHRESRPVPTVPVEPPAS PPPVPAGRPAPPLPRPTTADKGEESDDELSVHTSTLSLNNSPAPPPVPTHAVHEHIDSRRSSIYDPMPSTASTPA AEKRASRLPPPIPVNPPMPPSAQGRAPPPLPSDQLRRRSTVDSRTSALSAPRQAGEEAEGEVTEYDGDYDTDIAS GVKHKDALKAHERESSFDEGIFTDDYSIQSPRSPQESRHHHLPPPPPTAPRAVPPPPPSQPPRNARASIDTPRGP PPPPPDREPNSDDDVEYDPFNYAAPRHGLPASPPVPVGRPGPPPPFPTQAADEFDDLYDAPPVQSPVRERSDKRL SLALPQGQASGLPSPSAARTQRASVDILRSQPNLRRSMDVSRPSIDQGYIATDVDFAAYTLWWTKPKTPPPAFQN RTDLLFEVEETASTNRSGKTTVSKDVYILFIDYSQTVLNVQFDPKNPKDASFEQRHEPPPLPSRQDQLEQAHIQL GTRISEAVNSVQNSTVGDGTPFGLVQHLLSPLSDALLPVGTRAYGASVYSNLANASVSQNDEIRAGDIVSFRNAR FQGHRGTMHQKYSAEVGRPDHVGIVVDWDGTKKKIRAWEQGRESKKVKMESFKLNDLRSGECKVWRVMPRSWVGW EASK*
Coding	>Pro_DTO377G3_2|g8525.t1 ATGTCAGTTCCGCCCTTCACGGTCCGCTCGGTCTTCGAGTACGCGTCGGGCCACGATGATGACCTCAACTTCCCG ATCGGTCAAATCGTGACCGTCACCGCCCTGGAGGACGACGATTGGTACTACGGTGAATACTCAGACGCCCAGGGG GCCAGACAGGAGGGCATCTTCCCGAAAAACTTCGTTGAAAAATATGAGCCTCCGGCCCCTCCGAGGCCATCTCGA CCCAGGCCCAAAAAGGAGCCCGAGACGTTGCCAGTGGAGTCTCCCGTGGTCGAAAGCAAGCAGGCTGAGCGCGAG CCCGAGCCCGCGGTGCAGCCTACAGAGGAAGATTATGGGATTCAATCTTCGCAGCCACTGCCCCAGTCCCCTCGT CTACATGCGAGTGCCCCTGTATCAGAAGTTGTATCCTCGCCCCCGCAGCCAGCAAAGGCGCCCGCTCCCGCCCAT CCCGTGGCCCCAACCGAATCCGCAGCCAAAGCACCCTCAAAACCTGCGCCTCCAGCTGTAGCGGATAAGCCCTCG GGGTCATCATTCAGGGATCGTATTGCTGCCTTCAATAAACCTGCCGCTGCACCGGTTACGCCATTCAAACCCGGT GGTTCCCAGCCATCCTTCGTCAAGAAGCCTTTCGTCGCACCACCTCCTAGCCGGGATGCCTATAAGCCTCCACCA AGGGAACCTGCGCCCAAGATCTATAAACGAGAGGAGGATCCAGATGTGAAGGAACAAATTGCCCGCGAGCCTCCG GTTTCTGAAAGCCGGCCTGCCCATATTGAAGGTGGCGAAGAGGGAGCAGAGGACCAGCCTAAGCCAACTAGTCTG AAAGACCGAATTGCTTTGCTTCAGAAGCAGCAATTAGAGCAAGCTCAACGTCATGCAGAGGCAGCTCAGAAGAAA GAAAAACCCTCTCGCCCTCCCAAGAAGTCGATGGACGAACCCGTGGCTCCCGCAGTCCTCGACGAGGAACAGGAA CCTCCCTCCGTTGAAGAACCACCGGCTACTCGCGATACTAGTGTTGATACATTGAGGGCTGCGGCCCCTCCTTCA CAGCCCCCTGCCCCATTCTCACCCACCCAGGAAGTCGCGAGTGACGCCAATGATGCCGACTACTCCGCTGCTGCA GACTCCGAGGATGCCGGCGAAACATCCACCAGCAAGGACGATGAGGAAGATCAGGCTCAACCGCGTCCAGTTTCT CGTCGTCAACCGTTGACTCCTGCAGTCGAACAAACTGCCGAGGCAGATGTTGAAGACGAGGGCGATGCAGAGGAA GAGGAAGAGGAGGAAATGGACCCTGAAACTAAACGCAGAATGGAGTTGCGTGAGCGAATGGCCAAGATGAGCGGA GGAATGGGCATGATGGGTCTCTTCGGCCCGCCTATCGGAGGTATGCCAGGTATGCCAGGTATGGCTAGTGCCGGT AGTGCTCGCAAGCCCAAGACTCCCATCGAGTCAGAGAAGCGGCTTGGAGAGCTCGAATCTGAGCCCACTTCCCCT GCCAATGCGCCCCCTGTCCCTATGATCCCACTTCCTGGGATGAACGCGGCTAGCAAGCCGGTACCTTCTTATACT GAGGTGGAGAAGGAAGAGGAGGAGCCTTTGGCAACTCCTCTCACTGAACAACACCCCGCACGCGATGTGCCAGAC GTCGAGGAGGTCGTCCACGAAGGTGCACTGCCTCGTACCTCTATTGACCGTCCGGCCCCGGCTCCACCATCTCAA GATCGTTCCGCGCCTCCTCCGCCTCACCGAGAGTCAAGGCCCGTCCCGACAGTTCCAGTCGAGCCACCGGCTTCA CCTCCGCCAGTTCCTGCTGGTCGACCAGCTCCTCCTCTACCACGGCCCACAACTGCCGACAAGGGCGAAGAGTCT GATGATGAATTGTCGGTGCACACATCTACTCTGTCGTTGAATAATTCGCCTGCTCCACCACCCGTGCCTACACAT GCGGTTCATGAACATATTGACTCTCGCCGATCTTCAATATACGACCCTATGCCCTCTACGGCTTCGACCCCCGCG GCTGAAAAGAGAGCTAGTCGTCTACCACCCCCTATTCCAGTCAATCCGCCAATGCCACCATCGGCGCAGGGCCGC GCTCCCCCTCCCCTGCCTTCTGACCAGCTTCGTCGCCGATCTACCGTCGACAGTCGCACGAGTGCGTTATCTGCT CCTCGACAGGCTGGAGAAGAAGCGGAAGGAGAGGTGACTGAATATGATGGAGACTATGACACAGATATCGCATCG GGTGTGAAACACAAGGATGCTCTGAAAGCCCACGAGCGTGAATCCAGCTTTGACGAGGGTATTTTCACCGACGAC TATTCCATCCAGTCTCCGCGCAGCCCCCAGGAATCCCGGCATCATCACCTACCTCCTCCTCCACCCACGGCTCCC AGAGCAGTTCCGCCTCCACCGCCAAGCCAGCCGCCCCGGAATGCACGTGCGTCTATCGACACACCTAGGGGACCG CCGCCCCCTCCGCCGGACAGAGAGCCAAACAGCGATGATGATGTTGAATATGACCCTTTCAACTACGCTGCTCCC CGACATGGTCTTCCGGCGTCTCCACCCGTCCCAGTCGGTCGCCCAGGGCCGCCTCCTCCTTTCCCAACACAAGCG GCCGATGAATTTGACGATCTATATGATGCCCCTCCTGTGCAAAGCCCAGTAAGAGAAAGGAGTGATAAGCGCCTT TCACTGGCGCTTCCCCAAGGCCAGGCTTCGGGTTTGCCATCCCCGTCCGCAGCTCGAACCCAGCGCGCATCTGTG GATATTCTAAGAAGTCAGCCCAATCTTCGCCGATCTATGGATGTTTCTCGCCCATCTATTGACCAAGGCTACATC GCCACCGATGTTGATTTCGCCGCGTATACCCTCTGGTGGACTAAACCCAAGACACCGCCTCCAGCTTTCCAGAAC CGTACTGATCTGCTTTTCGAGGTCGAGGAGACTGCATCTACGAACCGCAGTGGCAAAACGACAGTCTCTAAGGAC GTCTATATTCTATTCATCGATTACTCTCAGACAGTGTTGAATGTCCAGTTCGATCCCAAGAACCCCAAGGATGCT TCCTTCGAGCAGCGCCATGAACCCCCACCGCTCCCGTCTCGCCAGGATCAGCTCGAGCAGGCTCACATTCAGCTT GGAACCCGAATCTCGGAAGCCGTCAACTCGGTCCAAAACTCTACCGTTGGAGACGGCACTCCGTTCGGATTGGTC CAGCACCTGCTCAGTCCTCTTTCCGACGCGCTACTTCCGGTGGGGACCCGCGCTTACGGTGCCTCGGTTTATTCA AACCTGGCCAATGCCTCCGTGTCTCAGAACGATGAAATCCGCGCTGGTGACATTGTCAGCTTCCGCAATGCCCGA TTCCAGGGTCACCGCGGTACTATGCACCAGAAGTACAGCGCCGAGGTTGGAAGACCCGACCACGTCGGCATCGTG GTCGATTGGGATGGCACGAAGAAGAAGATCCGAGCCTGGGAGCAAGGCCGCGAGAGCAAGAAGGTCAAAATGGAG AGCTTTAAGCTCAACGACCTCCGTAGTGGTGAATGCAAGGTCTGGCGAGTGATGCCCCGTAGCTGGGTGGGCTGG GAAGCCAGTAAGTAA
Transcript	>Pro_DTO377G3_2|g8525.t1 ATGTCAGTTCCGCCCTTCACGGTCCGCTCGGTCTTCGAGTACGCGTCGGGCCACGATGATGACCTCAACTTCCCG ATCGGTCAAATCGTGACCGTCACCGCCCTGGAGGACGACGATTGGTACTACGGTGAATACTCAGACGCCCAGGGG GCCAGACAGGAGGGCATCTTCCCGAAAAACTTCGTTGAAAAATATGAGCCTCCGGCCCCTCCGAGGCCATCTCGA CCCAGGCCCAAAAAGGAGCCCGAGACGTTGCCAGTGGAGTCTCCCGTGGTCGAAAGCAAGCAGGCTGAGCGCGAG CCCGAGCCCGCGGTGCAGCCTACAGAGGAAGATTATGGGATTCAATCTTCGCAGCCACTGCCCCAGTCCCCTCGT CTACATGCGAGTGCCCCTGTATCAGAAGTTGTATCCTCGCCCCCGCAGCCAGCAAAGGCGCCCGCTCCCGCCCAT CCCGTGGCCCCAACCGAATCCGCAGCCAAAGCACCCTCAAAACCTGCGCCTCCAGCTGTAGCGGATAAGCCCTCG GGGTCATCATTCAGGGATCGTATTGCTGCCTTCAATAAACCTGCCGCTGCACCGGTTACGCCATTCAAACCCGGT GGTTCCCAGCCATCCTTCGTCAAGAAGCCTTTCGTCGCACCACCTCCTAGCCGGGATGCCTATAAGCCTCCACCA AGGGAACCTGCGCCCAAGATCTATAAACGAGAGGAGGATCCAGATGTGAAGGAACAAATTGCCCGCGAGCCTCCG GTTTCTGAAAGCCGGCCTGCCCATATTGAAGGTGGCGAAGAGGGAGCAGAGGACCAGCCTAAGCCAACTAGTCTG AAAGACCGAATTGCTTTGCTTCAGAAGCAGCAATTAGAGCAAGCTCAACGTCATGCAGAGGCAGCTCAGAAGAAA GAAAAACCCTCTCGCCCTCCCAAGAAGTCGATGGACGAACCCGTGGCTCCCGCAGTCCTCGACGAGGAACAGGAA CCTCCCTCCGTTGAAGAACCACCGGCTACTCGCGATACTAGTGTTGATACATTGAGGGCTGCGGCCCCTCCTTCA CAGCCCCCTGCCCCATTCTCACCCACCCAGGAAGTCGCGAGTGACGCCAATGATGCCGACTACTCCGCTGCTGCA GACTCCGAGGATGCCGGCGAAACATCCACCAGCAAGGACGATGAGGAAGATCAGGCTCAACCGCGTCCAGTTTCT CGTCGTCAACCGTTGACTCCTGCAGTCGAACAAACTGCCGAGGCAGATGTTGAAGACGAGGGCGATGCAGAGGAA GAGGAAGAGGAGGAAATGGACCCTGAAACTAAACGCAGAATGGAGTTGCGTGAGCGAATGGCCAAGATGAGCGGA GGAATGGGCATGATGGGTCTCTTCGGCCCGCCTATCGGAGGTATGCCAGGTATGCCAGGTATGGCTAGTGCCGGT AGTGCTCGCAAGCCCAAGACTCCCATCGAGTCAGAGAAGCGGCTTGGAGAGCTCGAATCTGAGCCCACTTCCCCT GCCAATGCGCCCCCTGTCCCTATGATCCCACTTCCTGGGATGAACGCGGCTAGCAAGCCGGTACCTTCTTATACT GAGGTGGAGAAGGAAGAGGAGGAGCCTTTGGCAACTCCTCTCACTGAACAACACCCCGCACGCGATGTGCCAGAC GTCGAGGAGGTCGTCCACGAAGGTGCACTGCCTCGTACCTCTATTGACCGTCCGGCCCCGGCTCCACCATCTCAA GATCGTTCCGCGCCTCCTCCGCCTCACCGAGAGTCAAGGCCCGTCCCGACAGTTCCAGTCGAGCCACCGGCTTCA CCTCCGCCAGTTCCTGCTGGTCGACCAGCTCCTCCTCTACCACGGCCCACAACTGCCGACAAGGGCGAAGAGTCT GATGATGAATTGTCGGTGCACACATCTACTCTGTCGTTGAATAATTCGCCTGCTCCACCACCCGTGCCTACACAT GCGGTTCATGAACATATTGACTCTCGCCGATCTTCAATATACGACCCTATGCCCTCTACGGCTTCGACCCCCGCG GCTGAAAAGAGAGCTAGTCGTCTACCACCCCCTATTCCAGTCAATCCGCCAATGCCACCATCGGCGCAGGGCCGC GCTCCCCCTCCCCTGCCTTCTGACCAGCTTCGTCGCCGATCTACCGTCGACAGTCGCACGAGTGCGTTATCTGCT CCTCGACAGGCTGGAGAAGAAGCGGAAGGAGAGGTGACTGAATATGATGGAGACTATGACACAGATATCGCATCG GGTGTGAAACACAAGGATGCTCTGAAAGCCCACGAGCGTGAATCCAGCTTTGACGAGGGTATTTTCACCGACGAC TATTCCATCCAGTCTCCGCGCAGCCCCCAGGAATCCCGGCATCATCACCTACCTCCTCCTCCACCCACGGCTCCC AGAGCAGTTCCGCCTCCACCGCCAAGCCAGCCGCCCCGGAATGCACGTGCGTCTATCGACACACCTAGGGGACCG CCGCCCCCTCCGCCGGACAGAGAGCCAAACAGCGATGATGATGTTGAATATGACCCTTTCAACTACGCTGCTCCC CGACATGGTCTTCCGGCGTCTCCACCCGTCCCAGTCGGTCGCCCAGGGCCGCCTCCTCCTTTCCCAACACAAGCG GCCGATGAATTTGACGATCTATATGATGCCCCTCCTGTGCAAAGCCCAGTAAGAGAAAGGAGTGATAAGCGCCTT TCACTGGCGCTTCCCCAAGGCCAGGCTTCGGGTTTGCCATCCCCGTCCGCAGCTCGAACCCAGCGCGCATCTGTG GATATTCTAAGAAGTCAGCCCAATCTTCGCCGATCTATGGATGTTTCTCGCCCATCTATTGACCAAGGCTACATC GCCACCGATGTTGATTTCGCCGCGTATACCCTCTGGTGGACTAAACCCAAGACACCGCCTCCAGCTTTCCAGAAC CGTACTGATCTGCTTTTCGAGGTCGAGGAGACTGCATCTACGAACCGCAGTGGCAAAACGACAGTCTCTAAGGAC GTCTATATTCTATTCATCGATTACTCTCAGACAGTGTTGAATGTCCAGTTCGATCCCAAGAACCCCAAGGATGCT TCCTTCGAGCAGCGCCATGAACCCCCACCGCTCCCGTCTCGCCAGGATCAGCTCGAGCAGGCTCACATTCAGCTT GGAACCCGAATCTCGGAAGCCGTCAACTCGGTCCAAAACTCTACCGTTGGAGACGGCACTCCGTTCGGATTGGTC CAGCACCTGCTCAGTCCTCTTTCCGACGCGCTACTTCCGGTGGGGACCCGCGCTTACGGTGCCTCGGTTTATTCA AACCTGGCCAATGCCTCCGTGTCTCAGAACGATGAAATCCGCGCTGGTGACATTGTCAGCTTCCGCAATGCCCGA TTCCAGGGTCACCGCGGTACTATGCACCAGAAGTACAGCGCCGAGGTTGGAAGACCCGACCACGTCGGCATCGTG GTCGATTGGGATGGCACGAAGAAGAAGATCCGAGCCTGGGAGCAAGGCCGCGAGAGCAAGAAGGTCAAAATGGAG AGCTTTAAGCTCAACGACCTCCGTAGTGGTGAATGCAAGGTCTGGCGAGTGATGCCCCGTAGCTGGGTGGGCTGG GAAGCCAGTAAGTAA
Gene	>Pro_DTO377G3_2|g8525.t1 ATGTCAGTTCCGCCCTTCACGGTCCGCTCGGTCTTCGAGTACGCGTCGGGCCACGATGATGACCTCAACTTCCCG ATCGGTCAAATCGTGACCGTCACCGCCCTGGAGGACGACGATTGGTACTACGGTGAATACTCAGACGCCCAGGGG GCCAGACAGGAGGGCATCTTCCCGAAAAACTTCGTTGAAAAATATGAGCCTCCGGCCCCTCCGAGGCCATCTCGA CCCAGGCCCAAAAAGGAGCCCGAGACGTTGCCAGTGGAGTCTCCCGTGGTCGAAAGCAAGCAGGCTGAGCGCGAG CCCGAGCCCGCGGTGCAGCCTACAGAGGAAGATTATGGGATTCAATCTTCGCAGCCACTGCCCCAGTCCCCTCGT CTACATGCGAGTGCCCCTGTATCAGAAGTTGTATCCTCGCCCCCGCAGCCAGCAAAGGCGCCCGCTCCCGCCCAT CCCGTGGCCCCAACCGAATCCGCAGCCAAAGCACCCTCAAAACCTGCGCCTCCAGCTGTAGCGGATAAGCCCTCG GGGTCATCATTCAGGGATCGTATTGCTGCCTTCAATAAACCTGCCGCTGCACCGGTTACGCCATTCAAACCCGGT GGTTCCCAGCCATCCTTCGTCAAGAAGCCTTTCGTCGCACCACCTCCTAGCCGGGATGCCTATAAGCCTCCACCA AGGGAACCTGCGCCCAAGATCTATAAACGAGAGGAGGATCCAGATGTGAAGGAACAAATTGCCCGCGAGCCTCCG GTTTCTGAAAGCCGGCCTGCCCATATTGAAGGTGGCGAAGAGGGAGCAGAGGACCAGCCTAAGCCAACTAGTCTG AAAGACCGAATTGCTTTGCTTCAGAAGCAGCAATTAGAGCAAGCTCAACGTCATGCAGAGGCAGCTCAGAAGAAA GAAAAACCCTCTCGCCCTCCCAAGAAGTCGATGGACGAACCCGTGGCTCCCGCAGTCCTCGACGAGGAACAGGAA CCTCCCTCCGTTGAAGAACCACCGGCTACTCGCGATACTAGTGTTGATACATTGAGGGCTGCGGCCCCTCCTTCA CAGCCCCCTGCCCCATTCTCACCCACCCAGGAAGTCGCGAGTGACGCCAATGATGCCGACTACTCCGCTGCTGCA GACTCCGAGGATGCCGGCGAAACATCCACCAGCAAGGACGATGAGGAAGATCAGGCTCAACCGCGTCCAGTTTCT CGTCGTCAACCGTTGACTCCTGCAGTCGAACAAACTGCCGAGGCAGATGTTGAAGACGAGGGCGATGCAGAGGAA GAGGAAGAGGAGGAAATGGACCCTGAAACTAAACGCAGAATGGAGTTGCGTGAGCGAATGGCCAAGATGAGCGGA GGAATGGGCATGATGGGTCTCTTCGGCCCGCCTATCGGAGGTATGCCAGGTATGCCAGGTATGGCTAGTGCCGGT AGTGCTCGCAAGCCCAAGACTCCCATCGAGTCAGAGAAGCGGCTTGGAGAGCTCGAATCTGAGCCCACTTCCCCT GCCAATGCGCCCCCTGTCCCTATGATCCCACTTCCTGGGATGAACGCGGCTAGCAAGCCGGTACCTTCTTATACT GAGGTGGAGAAGGAAGAGGAGGAGCCTTTGGCAACTCCTCTCACTGAACAACACCCCGCACGCGATGTGCCAGAC GTCGAGGAGGTCGTCCACGAAGGTGCACTGCCTCGTACCTCTATTGACCGTCCGGCCCCGGCTCCACCATCTCAA GGTAAATTATTCTCCAGCAGTCTGATGCATGGTTCCAATTCCTGATAGTCGCAGATCGTTCCGCGCCTCCTCCGC CTCACCGAGAGTCAAGGCCCGTCCCGACAGTTCCAGTCGAGCCACCGGCTTCACCTCCGCCAGTTCCTGCTGGTA AGTACCCAGATCCGGAAGCAAATTATACGACCTGGGCATTAACGATGATATACAGGTCGACCAGCTCCTCCTCTA CCACGGCCCACAACTGCCGACAAGGGCGAAGAGTCTGATGATGAATTGTCGGTGCACACATCTACTCTGTCGTTG AATAATTCGCCTGCTCCACCACCCGTGCCTACACATGCGGTTCATGAACATATTGACTCTCGCCGATCTTCAATA TACGACCCTATGCCCTCTACGGCTTCGACCCCCGCGGCTGAAAAGAGAGCTAGTCGTCTACCACCCCCTATTCCA GTCAATCCGCCAATGCCACCATCGGCGCAGGGCCGCGCTCCCCCTCCCCTGCCTTCTGACCAGCTTCGTCGCCGA TCTACCGTCGACAGTCGCACGAGTGCGTTATCTGCTCCTCGACAGGCTGGAGAAGAAGCGGAAGGAGAGGTGACT GAATATGATGGAGACTATGACACAGATATCGCATCGGGTGTGAAACACAAGGATGCTCTGAAAGCCCACGAGCGT GAATCCAGCTTTGACGAGGGTATTTTCACCGACGACTATTCCATCCAGTCTCCGCGCAGCCCCCAGGAATCCCGG CATCATCACCTACCTCCTCCTCCACCCACGGCTCCCAGAGCAGTTCCGCCTCCACCGCCAAGCCAGCCGCCCCGG AATGCACGTGCGTCTATCGACACACCTAGGGGACCGCCGCCCCCTCCGCCGGACAGAGAGCCAAACAGCGATGAT GATGTTGAATATGACCCTTTCAACTACGCTGCTCCCCGACATGGTCTTCCGGCGTCTCCACCCGTCCCAGTCGGT CGCCCAGGGCCGCCTCCTCCTTTCCCAACACAAGCGGCCGATGAATTTGACGATCTATATGATGCCCCTCCTGTG CAAAGCCCAGTAAGAGAAAGGAGTGATAAGCGCCTTTCACTGGCGCTTCCCCAAGGCCAGGCTTCGGGTTTGCCA TCCCCGTCCGCAGCTCGAACCCAGCGCGCATCTGTGGATATTCTAAGAAGTCAGCCCAATCTTCGCCGATCTATG GATGTTTCTCGCCCATCTATTGACCAAGGCTACATCGCCACCGATGTTGATTTCGCCGCGTATACCCTCTGGTGG ACTAAACCCAAGACACCGCCTCCAGCTTTCCAGAACCGTACTGATCTGCTTTTCGAGGTCGAGGAGACTGCATCT ACGAACCGCAGTGGCAAAACGACAGTCTCTAAGGACGTCTATATTCTATTCATCGATTACTCTCAGACAGTGTTG AATGTCCAGTTCGATCCCAAGAACCCCAAGGATGCTTCCTTCGAGCAGCGCCATGAACCCCCACCGCTCCCGTCT CGCCAGGATCAGCTCGAGCAGGCTCACATTCAGCTTGGAACCCGAATCTCGGAAGCCGTCAACTCGGTCCAAAAC TCTACCGTTGGAGACGGCACTCCGTTCGGATTGGTCCAGCACCTGCTCAGTCCTCTTTCCGACGCGCTACTTCCG GTGGGGACCCGCGCTTACGGTGCCTCGGTTTATTCAAACCTGGCCAATGCCTCCGTGTCTCAGAACGATGAAATC CGCGCTGGTGACATTGTCAGCTTCCGCAATGCCCGATTCCAGGGTCACCGCGGTACTATGCACCAGAAGTACAGC GCCGAGGTTGGAAGACCCGACCACGTCGGCATCGTGGTCGATTGGGATGGCACGAAGAAGAAGATCCGAGCCTGG GAGCAAGGCCGCGAGAGCAAGAAGGTCAAAATGGAGAGCTTTAAGCTCAACGACCTCCGTAGTGGTGAATGCAAG GTCTGGCGAGTGATGCCCCGTAGCTGGGTGGGCTGGGAAGCCAGTAAGTAA