Fungal Genomics

Agaricus bisporus var bisporus H39 Agaricus bisporus var bisporus H97 Agaricus bisporus var burnettii H119p4 Aspergillus niger CBS 112.32 Aspergillus niger CBS 113.50 Aspergillus niger CBS 115988 Aspergillus niger CBS 115989 Aspergillus niger CBS 118.52 Aspergillus niger CBS 124.48 Aspergillus niger CBS 131.52 Aspergillus niger CBS 133816 Aspergillus niger CBS 147320 Aspergillus niger CBS 147321 Aspergillus niger CBS 147322 Aspergillus niger CBS 147323 Aspergillus niger CBS 147324 Aspergillus niger CBS 147343 Aspergillus niger CBS 147344 Aspergillus niger CBS 147345 Aspergillus niger CBS 147346 Aspergillus niger CBS 147347 Aspergillus niger CBS 147352 Aspergillus niger CBS 147353 Aspergillus niger CBS 147371 Aspergillus niger CBS 147482 Aspergillus niger CBS 630.78 Aspergillus niger CBS 769.97 Ophiocordyceps australis 1348a (Ghana) Ophiocordyceps australis map64 (Brazil) Ophiocordyceps camponoti-floridani Ophiocordyceps camponoti-rufipedis Ophiocordyceps kimflemingae Ophiocordyceps subramaniannii Penicillium roqueforti DTO002I6 Penicillium roqueforti DTO003C3 Penicillium roqueforti DTO003H1 (CBS 147308) Penicillium roqueforti DTO006G1 Penicillium roqueforti DTO006G7 Penicillium roqueforti DTO012A1 Penicillium roqueforti DTO012A2 (CBS 147309) Penicillium roqueforti DTO012A6 (CBS 147310) Penicillium roqueforti DTO012A7 Penicillium roqueforti DTO012A8 Penicillium roqueforti DTO012A9 Penicillium roqueforti DTO013E5 Penicillium roqueforti DTO013F2 Penicillium roqueforti DTO013F5 (CBS 147311) Penicillium roqueforti DTO027I6 Penicillium roqueforti DTO032C6 Penicillium roqueforti DTO039G3 Penicillium roqueforti DTO046C5 Penicillium roqueforti DTO070G2 (CBS 147317) Penicillium roqueforti DTO081F9 (CBS 147318) Penicillium roqueforti DTO101D6 (CBS 147325) Penicillium roqueforti DTO102I9 (CBS 147326) Penicillium roqueforti DTO126G2 (CBS 147330) Penicillium roqueforti DTO127F7 (CBS 147331) Penicillium roqueforti DTO127F9 (CBS 147332) Penicillium roqueforti DTO130C1 (CBS 147333) Penicillium roqueforti DTO163C3 (CBS 147337) Penicillium roqueforti DTO163F5 (CBS 147338) Penicillium roqueforti DTO163G4 (CBS 147339) Penicillium roqueforti DTO265D5 (CBS 147372) Penicillium roqueforti DTO369A1 (CBS 147354) Penicillium roqueforti DTO375B1 (CBS 147355) Penicillium roqueforti DTO377G2 (LCP 96.3914a) Penicillium roqueforti LCP96 04111 Rhodonia placenta FPRL280

General Properties

Protein ID	Pro_DTO377G3_2|g8476.t1
Gene name
Location	scaffold_33:176522..179974
Strand	+
Gene length (bp)	3452
Transcript length (bp)	3324
Coding sequence length (bp)	3324
Protein length (aa)	1108

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PFAM Domains

PFAM Domain ID	Short name	Long name	E-value	Start	End
PF00018	SH3_1	SH3 domain	6.5E-10	9	48
PF00018	SH3_1	SH3 domain	1.5E-05	74	119
PF00018	SH3_1	SH3 domain	7.3E-13	404	450
PF03983	SHD1	SLA1 homology domain 1, SHD1	1.5E-31	511	575
PF14604	SH3_9	Variant SH3 domain	8.2E-11	9	65
PF14604	SH3_9	Variant SH3 domain	1.5E-07	404	454
PF07653	SH3_2	Variant SH3 domain	2.3E-06	9	67

GO

GO Term	Description	Terminal node
GO:0005515	protein binding	Yes
GO:0043130	ubiquitin binding	Yes
GO:0008092	cytoskeletal protein binding	Yes
GO:0030674	protein-macromolecule adaptor activity	Yes
GO:0042802	identical protein binding	Yes
GO:0060090	molecular adaptor activity	No
GO:0005488	binding	No
GO:0032182	ubiquitin-like protein binding	No
GO:0003674	molecular_function	No

SignalP

[Help with interpreting these statistics]

SignalP signal predicted	Location (based on Ymax)	D score (significance: > 0.45)
No	1 - 63	0.45

Transmembrane Domains

(None)

Transcription Factor Class

(None)

Expression data

Analysis 1: Genome-wide gene expression in conidia of Penicillium roqueforti during growth at various temperatures and for various amounts of time. Published in Punt et al., 2020.

Expression values

Label	Description	Expression (RPKM)	Confidence interval (low)	Confidence interval (high)
3d_25C	Three days - 25 degrees Celsius	41.73	25.65	57.80
5d_25C	Five days - 25 degrees Celsius	45.26	27.77	62.75
7d_25C	Seven days - 25 degrees Celsius	40.39	24.78	56.00
10d_25C	Ten days - 25 degrees Celsius	42.94	26.12	59.75
7d_15C	Seven days - 15 degrees Celsius	47.41	28.93	65.89
7d_30C	Seven days - 30 degrees Celsius	39.40	24.21	54.59

Differential expression

Label1	Label2	Q-value	Significant difference
3d_25C	5d_25C	0.780540	no
3d_25C	7d_25C	0.923975	no
3d_25C	7d_15C	0.639483	no
3d_25C	7d_30C	0.855173	no
3d_25C	10d_25C	0.933107	no
5d_25C	7d_25C	0.681121	no
5d_25C	7d_15C	0.884766	no
5d_25C	7d_30C	0.596642	no
5d_25C	10d_25C	0.869707	no
7d_25C	7d_15C	0.536742	no
7d_25C	7d_30C	0.940486	no
7d_25C	10d_25C	0.845198	no
7d_15C	7d_30C	0.447444	no
7d_15C	10d_25C	0.735085	no
7d_30C	10d_25C	0.768319	no

Sequences

Type of sequence	Sequence
Locus	Download genbank file of locus The gene with 5 kb flanks (if sufficient flanking sequence is available). For use in cloning design programs. NOTE: features (genes or exons) that are only partially contained within the sequence are completely excluded.
Protein	>Pro_DTO377G3_2|g8476.t1 MGFIGVYSAVYDYQPQGAGELEIHEGDLLYILEKNADDAWWRAKKKASREDEDEPEGLVPNNYVEEVQPAHRATA LFDYTRQTDEEISFSEDAELMVYDTSDPDWTLVGANSEYGFAPSNYIEIIEDTSAETTPPPQPSVRAEPAAPTLP QRPTQTASEETEASPAASPVDMSHNPAAAAIASIIHKQHAPARVSAETTRDEPPPPSLPVRPSYDQEEDHEESPP PSLPRRPPSEHASPTMNRYSPDPTPPRPQQAAPAMGRDRTHVKASPPYNRAGEMTPRSPSGYHIYNINEMVEVMG KRKKMPTTLGINMATGIIFISPEGDDRQKEWSAEKLTHYSIEGKHVFVDLVRPSKSIDFHAGAKDTAHEIAAALG EIAGAYRAEGLREVIEAGEGGGPKKGQILYDFMAQGDDEVTVAVGDEVIILDDTKSEEWWMVRRLKNNKEGVVPS SYVEVIGLIPKAPLMPHEPGLSSVEKNRMEEMRLSKLAIGKSRTDSMDSSDRHSKRDSKIKSKPDMTKVRRWTDR TKDFTVEAQFIGLQDGKIQLHKVNGIKIAVPVSKMSVEDLEHVEKVAGVSLDEDKPLSSIRPRVTIGNDSKAGAS VQRSDYDWFDFFLKAGVGPHRCERYAQSFNKDAMDESVLPDITSEILQTLGLNQGDTLRVMKVLDAKYGRAPDKT KLRNVSFGGEEVIGNGEDGGQGGLFSGPGGVLRNNTRRARPTPNVPAGEVDPKAFGQGEEPKSSDSSASPPPAAA EKPAAGFEDDAWEVKQPKQPAGPPAATPTPPPAAAQVPQPTGAMADLTLLQAPLQPTPAQPTAPAAPPIPTLQPQ ATAVQSPAIQAQQTGATPSLFAQVAQIGQYQRSFSPQQTGFQAQARQRPQAPPTVGHNSLLPPPPQRPLSAPQNF SQLQNSFGPPPLQAQLTGLPQAGPPVAPPGQSLTEINQLRYQAAMQPQATGFMGQPQYQNGLMPQPTGFTPQSQF GIQQQQQQLPFGSQMAPQQTGFQGLGPQPTGFGGYGQFQQPMQTGINSVLPPALQPQPTGVNGYGNQSYTSPPPV PPIPQQPTATPLSPQKTGPAPPIRFGVKPDGPKKLEPQPTGLRANLSQATPNNPFGF*
Coding	>Pro_DTO377G3_2|g8476.t1 ATGGGTTTCATCGGTGTATACTCGGCTGTGTACGACTACCAGCCACAGGGAGCGGGCGAACTCGAGATTCACGAG GGCGACCTCCTCTACATTTTGGAAAAGAATGCGGATGATGCCTGGTGGAGGGCTAAAAAGAAGGCTAGTCGGGAG GATGAGGACGAACCTGAAGGCCTAGTTCCCAACAACTATGTCGAAGAGGTGCAACCAGCGCACAGAGCTACAGCC CTCTTCGACTATACGCGACAGACCGACGAGGAGATTTCCTTCTCAGAAGATGCTGAGCTGATGGTGTATGACACC TCGGATCCAGACTGGACGTTGGTTGGAGCCAACTCGGAGTATGGGTTTGCGCCGTCGAATTACATCGAAATCATC GAGGATACCTCCGCTGAAACTACTCCCCCTCCTCAACCTTCTGTTCGAGCCGAGCCTGCCGCGCCGACGCTTCCG CAGCGGCCGACGCAGACTGCATCGGAAGAAACCGAGGCATCCCCCGCCGCCTCTCCGGTTGATATGTCTCACAAC CCCGCTGCTGCTGCGATCGCCAGCATCATCCATAAGCAGCATGCCCCTGCGAGGGTATCTGCCGAGACGACCAGA GATGAACCCCCGCCACCCAGTCTTCCCGTCCGACCATCGTACGATCAAGAAGAGGACCACGAGGAGTCTCCGCCG CCTAGTCTGCCACGTCGACCACCTTCGGAACATGCGTCCCCCACTATGAACCGTTACTCGCCTGACCCAACTCCG CCACGTCCCCAGCAGGCGGCGCCTGCCATGGGTCGTGATCGGACACATGTCAAAGCATCACCCCCTTACAACCGG GCAGGTGAGATGACGCCTCGGTCCCCTTCCGGCTATCATATCTACAATATCAATGAGATGGTTGAAGTGATGGGC AAGAGAAAGAAGATGCCGACGACATTGGGAATCAACATGGCTACTGGAATCATCTTTATCTCTCCTGAAGGCGAT GATCGGCAGAAAGAATGGAGTGCAGAGAAGCTCACTCATTACTCGATCGAAGGCAAGCATGTCTTTGTTGACCTT GTCAGACCTAGCAAAAGTATCGATTTCCATGCAGGTGCCAAAGACACTGCCCACGAGATTGCAGCGGCACTCGGC GAGATCGCCGGTGCCTACCGGGCAGAAGGACTGCGTGAGGTGATCGAGGCAGGAGAAGGGGGCGGTCCCAAGAAG GGCCAGATCCTGTATGACTTTATGGCGCAAGGTGATGATGAAGTTACAGTAGCTGTGGGGGACGAGGTCATCATC CTTGATGATACTAAGTCTGAAGAGTGGTGGATGGTGCGGCGATTGAAGAACAACAAGGAGGGTGTTGTCCCTAGT AGCTATGTTGAAGTCATAGGATTGATACCGAAGGCGCCTTTGATGCCTCATGAACCAGGTTTGTCGAGTGTGGAA AAGAACCGGATGGAGGAGATGCGGCTGTCCAAACTTGCGATCGGCAAGTCACGGACGGACTCCATGGATTCATCG GACCGTCACAGCAAGCGCGACAGCAAAATCAAGTCGAAGCCCGATATGACTAAGGTGCGAAGGTGGACGGATCGG ACCAAGGATTTCACAGTGGAAGCCCAGTTCATAGGCCTCCAGGATGGTAAAATCCAGCTTCACAAGGTGAACGGT ATCAAGATTGCCGTCCCTGTCTCAAAGATGTCAGTTGAAGATCTCGAGCATGTGGAGAAAGTTGCCGGCGTCTCG CTAGATGAGGACAAACCTCTTTCAAGCATCCGACCTCGCGTTACCATTGGCAATGATTCCAAAGCTGGGGCTTCT GTGCAACGTTCCGATTACGATTGGTTTGACTTCTTCCTTAAGGCTGGCGTTGGGCCACATCGCTGTGAGCGATAC GCACAGTCATTTAACAAGGACGCGATGGACGAATCTGTGCTGCCGGACATTACATCTGAAATCCTTCAGACTCTG GGTCTAAACCAGGGTGATACCTTGCGAGTAATGAAGGTTTTGGATGCCAAATATGGCCGTGCCCCGGACAAGACC AAGCTTCGAAATGTCAGTTTCGGTGGTGAGGAAGTCATTGGCAATGGCGAGGACGGAGGGCAAGGTGGTCTGTTT TCCGGGCCCGGTGGTGTGCTGCGCAACAACACTCGCAGGGCCAGACCAACACCAAACGTTCCAGCCGGAGAGGTC GATCCCAAGGCGTTCGGGCAGGGAGAGGAACCTAAATCATCAGACAGCTCGGCAAGCCCACCACCTGCAGCAGCT GAAAAGCCTGCAGCCGGATTTGAAGATGATGCTTGGGAGGTGAAGCAGCCGAAGCAACCTGCTGGGCCACCTGCA GCCACCCCGACGCCACCGCCTGCGGCAGCTCAGGTTCCTCAGCCAACAGGGGCAATGGCGGATCTGACTTTGCTT CAAGCTCCTTTGCAGCCGACGCCGGCTCAGCCTACTGCACCAGCTGCCCCGCCTATACCCACCCTGCAGCCGCAG GCCACTGCCGTGCAATCACCAGCTATACAGGCTCAACAAACAGGTGCCACTCCTAGCTTGTTTGCGCAAGTGGCA CAGATAGGACAGTATCAACGATCTTTCAGCCCTCAACAGACCGGGTTCCAAGCACAGGCCAGACAACGCCCACAG GCCCCTCCGACAGTTGGGCATAATTCACTTCTGCCTCCGCCCCCGCAACGCCCACTGTCCGCGCCTCAGAACTTC TCGCAACTGCAAAACTCCTTTGGCCCTCCTCCATTGCAAGCTCAACTGACGGGCCTTCCCCAGGCGGGTCCTCCG GTTGCTCCTCCTGGCCAGAGTCTGACCGAAATAAACCAGCTACGTTACCAAGCCGCGATGCAGCCGCAAGCGACA GGATTTATGGGTCAACCTCAATATCAGAATGGCTTGATGCCGCAGCCCACCGGGTTTACTCCCCAGTCACAATTC GGTATCCAGCAACAGCAACAGCAACTGCCGTTTGGTAGCCAGATGGCCCCTCAACAAACTGGATTCCAGGGACTT GGGCCACAGCCCACAGGCTTTGGTGGATATGGGCAATTCCAACAACCAATGCAGACTGGTATCAACTCTGTCCTT CCCCCTGCACTGCAACCGCAACCCACTGGTGTCAATGGCTACGGCAACCAGTCCTACACATCTCCGCCTCCTGTG CCGCCAATTCCCCAGCAACCAACAGCGACCCCCCTGTCACCACAGAAGACCGGACCGGCTCCCCCCATCAGATTT GGTGTCAAGCCAGATGGTCCCAAGAAGCTTGAGCCACAACCGACTGGACTCAGAGCCAACCTTTCGCAAGCTACC CCCAATAATCCGTTCGGCTTCTAA
Transcript	>Pro_DTO377G3_2|g8476.t1 ATGGGTTTCATCGGTGTATACTCGGCTGTGTACGACTACCAGCCACAGGGAGCGGGCGAACTCGAGATTCACGAG GGCGACCTCCTCTACATTTTGGAAAAGAATGCGGATGATGCCTGGTGGAGGGCTAAAAAGAAGGCTAGTCGGGAG GATGAGGACGAACCTGAAGGCCTAGTTCCCAACAACTATGTCGAAGAGGTGCAACCAGCGCACAGAGCTACAGCC CTCTTCGACTATACGCGACAGACCGACGAGGAGATTTCCTTCTCAGAAGATGCTGAGCTGATGGTGTATGACACC TCGGATCCAGACTGGACGTTGGTTGGAGCCAACTCGGAGTATGGGTTTGCGCCGTCGAATTACATCGAAATCATC GAGGATACCTCCGCTGAAACTACTCCCCCTCCTCAACCTTCTGTTCGAGCCGAGCCTGCCGCGCCGACGCTTCCG CAGCGGCCGACGCAGACTGCATCGGAAGAAACCGAGGCATCCCCCGCCGCCTCTCCGGTTGATATGTCTCACAAC CCCGCTGCTGCTGCGATCGCCAGCATCATCCATAAGCAGCATGCCCCTGCGAGGGTATCTGCCGAGACGACCAGA GATGAACCCCCGCCACCCAGTCTTCCCGTCCGACCATCGTACGATCAAGAAGAGGACCACGAGGAGTCTCCGCCG CCTAGTCTGCCACGTCGACCACCTTCGGAACATGCGTCCCCCACTATGAACCGTTACTCGCCTGACCCAACTCCG CCACGTCCCCAGCAGGCGGCGCCTGCCATGGGTCGTGATCGGACACATGTCAAAGCATCACCCCCTTACAACCGG GCAGGTGAGATGACGCCTCGGTCCCCTTCCGGCTATCATATCTACAATATCAATGAGATGGTTGAAGTGATGGGC AAGAGAAAGAAGATGCCGACGACATTGGGAATCAACATGGCTACTGGAATCATCTTTATCTCTCCTGAAGGCGAT GATCGGCAGAAAGAATGGAGTGCAGAGAAGCTCACTCATTACTCGATCGAAGGCAAGCATGTCTTTGTTGACCTT GTCAGACCTAGCAAAAGTATCGATTTCCATGCAGGTGCCAAAGACACTGCCCACGAGATTGCAGCGGCACTCGGC GAGATCGCCGGTGCCTACCGGGCAGAAGGACTGCGTGAGGTGATCGAGGCAGGAGAAGGGGGCGGTCCCAAGAAG GGCCAGATCCTGTATGACTTTATGGCGCAAGGTGATGATGAAGTTACAGTAGCTGTGGGGGACGAGGTCATCATC CTTGATGATACTAAGTCTGAAGAGTGGTGGATGGTGCGGCGATTGAAGAACAACAAGGAGGGTGTTGTCCCTAGT AGCTATGTTGAAGTCATAGGATTGATACCGAAGGCGCCTTTGATGCCTCATGAACCAGGTTTGTCGAGTGTGGAA AAGAACCGGATGGAGGAGATGCGGCTGTCCAAACTTGCGATCGGCAAGTCACGGACGGACTCCATGGATTCATCG GACCGTCACAGCAAGCGCGACAGCAAAATCAAGTCGAAGCCCGATATGACTAAGGTGCGAAGGTGGACGGATCGG ACCAAGGATTTCACAGTGGAAGCCCAGTTCATAGGCCTCCAGGATGGTAAAATCCAGCTTCACAAGGTGAACGGT ATCAAGATTGCCGTCCCTGTCTCAAAGATGTCAGTTGAAGATCTCGAGCATGTGGAGAAAGTTGCCGGCGTCTCG CTAGATGAGGACAAACCTCTTTCAAGCATCCGACCTCGCGTTACCATTGGCAATGATTCCAAAGCTGGGGCTTCT GTGCAACGTTCCGATTACGATTGGTTTGACTTCTTCCTTAAGGCTGGCGTTGGGCCACATCGCTGTGAGCGATAC GCACAGTCATTTAACAAGGACGCGATGGACGAATCTGTGCTGCCGGACATTACATCTGAAATCCTTCAGACTCTG GGTCTAAACCAGGGTGATACCTTGCGAGTAATGAAGGTTTTGGATGCCAAATATGGCCGTGCCCCGGACAAGACC AAGCTTCGAAATGTCAGTTTCGGTGGTGAGGAAGTCATTGGCAATGGCGAGGACGGAGGGCAAGGTGGTCTGTTT TCCGGGCCCGGTGGTGTGCTGCGCAACAACACTCGCAGGGCCAGACCAACACCAAACGTTCCAGCCGGAGAGGTC GATCCCAAGGCGTTCGGGCAGGGAGAGGAACCTAAATCATCAGACAGCTCGGCAAGCCCACCACCTGCAGCAGCT GAAAAGCCTGCAGCCGGATTTGAAGATGATGCTTGGGAGGTGAAGCAGCCGAAGCAACCTGCTGGGCCACCTGCA GCCACCCCGACGCCACCGCCTGCGGCAGCTCAGGTTCCTCAGCCAACAGGGGCAATGGCGGATCTGACTTTGCTT CAAGCTCCTTTGCAGCCGACGCCGGCTCAGCCTACTGCACCAGCTGCCCCGCCTATACCCACCCTGCAGCCGCAG GCCACTGCCGTGCAATCACCAGCTATACAGGCTCAACAAACAGGTGCCACTCCTAGCTTGTTTGCGCAAGTGGCA CAGATAGGACAGTATCAACGATCTTTCAGCCCTCAACAGACCGGGTTCCAAGCACAGGCCAGACAACGCCCACAG GCCCCTCCGACAGTTGGGCATAATTCACTTCTGCCTCCGCCCCCGCAACGCCCACTGTCCGCGCCTCAGAACTTC TCGCAACTGCAAAACTCCTTTGGCCCTCCTCCATTGCAAGCTCAACTGACGGGCCTTCCCCAGGCGGGTCCTCCG GTTGCTCCTCCTGGCCAGAGTCTGACCGAAATAAACCAGCTACGTTACCAAGCCGCGATGCAGCCGCAAGCGACA GGATTTATGGGTCAACCTCAATATCAGAATGGCTTGATGCCGCAGCCCACCGGGTTTACTCCCCAGTCACAATTC GGTATCCAGCAACAGCAACAGCAACTGCCGTTTGGTAGCCAGATGGCCCCTCAACAAACTGGATTCCAGGGACTT GGGCCACAGCCCACAGGCTTTGGTGGATATGGGCAATTCCAACAACCAATGCAGACTGGTATCAACTCTGTCCTT CCCCCTGCACTGCAACCGCAACCCACTGGTGTCAATGGCTACGGCAACCAGTCCTACACATCTCCGCCTCCTGTG CCGCCAATTCCCCAGCAACCAACAGCGACCCCCCTGTCACCACAGAAGACCGGACCGGCTCCCCCCATCAGATTT GGTGTCAAGCCAGATGGTCCCAAGAAGCTTGAGCCACAACCGACTGGACTCAGAGCCAACCTTTCGCAAGCTACC CCCAATAATCCGTTCGGCTTCTAA
Gene	>Pro_DTO377G3_2|g8476.t1 ATGGGTTTCATCGGTGTATACTCGGCTGTGTACGACTACCAGCCACAGGGAGCGGGCGAACTCGAGATTCACGAG GGCGACCTCCTCTACATTTTGGAAAAGAATGCGGATGATGCCTGGTGGAGGGCTAAAAAGAAGGCTAGTCGGGAG GATGAGGACGAACCTGAAGGCCTAGTTCCCAACAACTATGTCGAAGAGGTGAGTCTCCGCCGATGGCACCCGCGC AGGCCTCGCTGCATGGACAATTGCTGATATTATATGAAACAGGTGCAACCAGCGCACAGAGCTACAGCCCTCTTC GACTATACGCGACAGACCGACGAGGAGATTTCCTTCTCAGAAGATGCTGAGCTGATGGTGTATGACACCTCGGAT CCAGACTGGACGTTGGTTGGAGCCAACTCGGAGTATGGGTTTGCGCCGTCGAATTACATCGAAATCATCGAGGAT ACCTCCGCTGAAACTACTCCCCCTCCTCAACCTTCTGTTCGAGCCGAGCCTGCCGCGCCGACGCTTCCGCAGCGG CCGACGCAGACTGCATCGGAAGAAACCGAGGCATCCCCCGCCGCCTCTCCGGTTGATATGTCTCACAACCCCGCT GCTGCTGCGATCGCCAGCATCATCCATAAGCAGCATGCCCCTGCGAGGGTATCTGCCGAGACGACCAGAGATGAA CCCCCGCCACCCAGTCTTCCCGTCCGACCATCGTACGATCAAGAAGAGGACCACGAGGAGTCTCCGCCGCCTAGT CTGCCACGTCGACCACCTTCGGAACATGCGTCCCCCACTATGAACCGTTACTCGCCTGACCCAACTCCGCCACGT CCCCAGCAGGCGGCGCCTGCCATGGGTCGTGATCGGACACATGTCAAAGCATCACCCCCTTACAACCGGGCAGGT GAGATGACGCCTCGGTCCCCTTCCGGCTATCATATCTACAATATCAATGAGATGGTTGAAGTGATGGGCAAGAGA AAGAAGATGCCGACGACATTGGGAATCAACATGGCTACTGGAATCATCTTTATCTCTCCTGAAGGCGATGATCGG CAGAAAGAATGGAGTGCAGAGAAGCTCACTCATTACTCGATCGAAGGCAAGCATGTCTTTGTTGACCTTGTCAGA CCTAGCAAAAGTATCGATTTCCATGCAGGTGCCAAAGACACTGCCCACGAGATTGCAGCGGCACTCGGCGAGATC GCCGGTGCCTACCGGGCAGAAGGACTGCGTGAGGTGATCGAGGCAGGAGAAGGGGGCGGTCCCAAGAAGGGCCAG ATCCTGTATGACTTTATGGCGCAAGGTGATGATGAAGTTACAGTAGCTGTGGGGGACGAGGTCATCATCCTTGAT GATACTAAGTCTGAAGAGTGGTGGATGGTGCGGCGATTGAAGAACAACAAGGAGGGTGTTGTCCCTAGTAGCTAT GTTGAAGTCATAGGATTGATACCGAAGGCGCCTTTGATGCCTCATGAACCAGGTTTGTCGAGTGTGGAAAAGAAC CGGATGGAGGAGATGCGGCTGTCCAAACTTGCGATCGGCAAGTCACGGACGGACTCCATGGATTCATCGGACCGT CACAGCAAGCGCGACAGCAAAATCAAGTCGAAGCCCGATATGACTAAGGTGCGAAGGTGGACGGATCGGACCAAG GATTTCACAGTGGAAGCCCAGTTCATAGGCCTCCAGGATGGTAAAATCCAGCTTCACAAGGTGAACGGTATCAAG ATTGCCGTCCCTGTCTCAAAGATGTCAGTTGAAGATCTCGAGCATGTGGAGAAAGTTGCCGGCGTCTCGCTAGAT GAGGACAAACCTCTTTCAAGCATCCGACCTCGCGTTACCATTGGCAATGATTCCAAAGCTGGGGCTTCTGTGCAA CGTTCCGATTACGATTGGTTTGACTTCTTCCTTAAGGCTGGCGTTGGGCCACATCGCTGTGAGCGATACGCACAG TCATTTAACAAGGACGCGATGGACGAATCTGTGCTGCCGGACATTACATCTGAAATCCTTCAGACTCTGGGTCTA AACCAGGGTGATACCTTGCGAGTAATGAAGGTTTTGGATGCCAAATATGGCCGTGCCCCGGACAAGACCAAGCTT CGAAATGTCAGTTTCGGTGGTGAGGAAGTCATTGGCAATGGCGAGGACGGAGGGCAAGGTGGTCTGTTTTCCGGG CCCGGTGGTGTGCTGCGCAACAACACTCGCAGGGCCAGACCAACACCAAACGTTCCAGCCGGAGAGGTCGATCCC AAGGCGTTCGGGCAGGGAGAGGAACCTAAATCATCAGACAGCTCGGCAAGCCCACCACCTGCAGCAGCTGAAAAG CCTGCAGCCGGATTTGAAGATGATGCTTGGGAGGTGAAGCAGCCGAAGCAACCTGCTGGGCCACCTGCAGCCACC CCGACGCCACCGCCTGCGGCAGCTCAGGTTCCTCAGCCAACAGGGGCAATGGCGGATCTGACTTTGCTTCAAGCT CCTTTGCAGCCGACGCCGGCTCAGCCTACTGCACCAGCTGCCCCGCCTATACCCACCCTGCAGCCGCAGGCCACT GCCGTGCAATCACCAGCTATACAGGCTCAACAAACAGGTGCCACTCCTAGCTTGTTTGCGCAAGTGGCACAGATA GGACAGTATCAACGATCTTTCAGCCCTCAACAGACCGGGTTCCAAGCACAGGCCAGACAACGCCCACAGGCCCCT CCGACAGTTGGGCATAATTCACTTCTGCCTCCGCCCCCGCAACGCCCACTGTCCGCGCCTCAGAACTTCTCGCAA CTGCAAAACTCCTTTGGCCCTCCTCCATTGCAAGCTCAACTGACGGGCCTTCCCCAGGCGGGTCCTCCGGTTGCT CCTCCTGGCCAGAGTCTGACCGAAATAAACCAGCTACGTTACCAAGCCGCGATGCAGCCGCAAGCGACAGGATTT ATGGGTCAACCTCAATATCAGAATGGCTTGATGCCGCAGCCCACCGGGTTTACTCCCCAGTCACAATTCGGTATC CAGCAACAGCAACAGCAACTGCCGTTTGGTAGCCAGATGGCCCCTCAACAAACTGGATTCCAGGGACTTGGGCCA CAGCCCACAGGCTTTGGTGGATATGGGCAATTCCAACAACCAATGCAGACTGGTATCAACTCTGTCCTTCCCCCT GCACTGCAACCGCAACCCACTGGTGTCAATGGCTACGGCAACCAGTCCTACACATCTCCGCCTCCTGTGCCGCCA ATTCCCCAGCAACCAACAGCGACCCCCCTGTCACCACAGAAGACCGGACCGGCTCCCCCCATCAGATTTGGTGTC AAGCCAGATGGTCCCAAGAAGCTTGAGCCACAACCGACTGGACTCAGAGCCAACCTTTCGCAAGCTAGTAAGTTT TTCTTACCATTAAAGGTGGTAAACTTGAACAGAAACTAACTCAATTTACAGCCCCCAATAATCCGTTCGGCTTCT AA