Fungal Genomics

Agaricus bisporus var bisporus H39 Agaricus bisporus var bisporus H97 Agaricus bisporus var burnettii H119p4 Aspergillus niger CBS 112.32 Aspergillus niger CBS 113.50 Aspergillus niger CBS 115988 Aspergillus niger CBS 115989 Aspergillus niger CBS 118.52 Aspergillus niger CBS 124.48 Aspergillus niger CBS 131.52 Aspergillus niger CBS 133816 Aspergillus niger CBS 147320 Aspergillus niger CBS 147321 Aspergillus niger CBS 147322 Aspergillus niger CBS 147323 Aspergillus niger CBS 147324 Aspergillus niger CBS 147343 Aspergillus niger CBS 147344 Aspergillus niger CBS 147345 Aspergillus niger CBS 147346 Aspergillus niger CBS 147347 Aspergillus niger CBS 147352 Aspergillus niger CBS 147353 Aspergillus niger CBS 147371 Aspergillus niger CBS 147482 Aspergillus niger CBS 630.78 Aspergillus niger CBS 769.97 Niveomyces coronatus CBS 149186 Ophiocordyceps australis 1348a (Ghana) Ophiocordyceps australis map64 (Brazil) Ophiocordyceps camponoti-floridani Ophiocordyceps camponoti-rufipedis Ophiocordyceps kimflemingae Ophiocordyceps subramaniannii Penicillium roqueforti DTO002I6 Penicillium roqueforti DTO003C3 Penicillium roqueforti DTO003H1 (CBS 147308) Penicillium roqueforti DTO006G1 Penicillium roqueforti DTO006G7 Penicillium roqueforti DTO012A1 Penicillium roqueforti DTO012A2 (CBS 147309) Penicillium roqueforti DTO012A6 (CBS 147310) Penicillium roqueforti DTO012A7 Penicillium roqueforti DTO012A8 Penicillium roqueforti DTO012A9 Penicillium roqueforti DTO013E5 Penicillium roqueforti DTO013F2 Penicillium roqueforti DTO013F5 (CBS 147311) Penicillium roqueforti DTO027I6 Penicillium roqueforti DTO032C6 Penicillium roqueforti DTO039G3 Penicillium roqueforti DTO046C5 Penicillium roqueforti DTO070G2 (CBS 147317) Penicillium roqueforti DTO081F9 (CBS 147318) Penicillium roqueforti DTO101D6 (CBS 147325) Penicillium roqueforti DTO102I9 (CBS 147326) Penicillium roqueforti DTO126G2 (CBS 147330) Penicillium roqueforti DTO127F7 (CBS 147331) Penicillium roqueforti DTO127F9 (CBS 147332) Penicillium roqueforti DTO130C1 (CBS 147333) Penicillium roqueforti DTO163C3 (CBS 147337) Penicillium roqueforti DTO163F5 (CBS 147338) Penicillium roqueforti DTO163G4 (CBS 147339) Penicillium roqueforti DTO265D5 (CBS 147372) Penicillium roqueforti DTO369A1 (CBS 147354) Penicillium roqueforti DTO375B1 (CBS 147355) Penicillium roqueforti DTO377G2 (LCP 96.3914a) Penicillium roqueforti LCP96 04111 Rhodonia placenta FPRL280 Torrubiellomyces zombiae CBS 149187

General Properties

Protein ID	Pro_DTO377G3_2|g7926.t1
Gene name
Location	scaffold_27:183518..187214
Strand	+
Gene length (bp)	3696
Transcript length (bp)	3597
Coding sequence length (bp)	3597
Protein length (aa)	1199

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PFAM Domains

PFAM Domain ID	Short name	Long name	E-value	Start	End
PF03142	Chitin_synth_2	Chitin synthase	6.8E-289	651	1172
PF13632	Glyco_trans_2_3	Glycosyl transferase family group 2	5.6E-10	851	1085

GO

(None)

SignalP

[Help with interpreting these statistics]

SignalP signal predicted	Location (based on Ymax)	D score (significance: > 0.45)
No	1 - 11	0.45

Transmembrane Domains

Domain #	Start	End	Length
1	220	242	22
2	472	494	22
3	992	1011	19
4	1044	1066	22
5	1076	1098	22
6	1105	1127	22

Transcription Factor Class

(None)

Expression data

Analysis 1: Genome-wide gene expression in conidia of Penicillium roqueforti during growth at various temperatures and for various amounts of time. Published in Punt et al., 2020.

Expression values

Label	Description	Expression (RPKM)	Confidence interval (low)	Confidence interval (high)
3d_25C	Three days - 25 degrees Celsius	12.03	6.74	17.31
5d_25C	Five days - 25 degrees Celsius	10.53	5.63	15.42
7d_25C	Seven days - 25 degrees Celsius	10.45	5.38	15.52
10d_25C	Ten days - 25 degrees Celsius	5.80	2.69	8.92
7d_15C	Seven days - 15 degrees Celsius	9.58	4.47	14.68
7d_30C	Seven days - 30 degrees Celsius	22.07	12.43	31.70

Differential expression

Label1	Label2	Q-value	Significant difference
3d_25C	5d_25C	0.685497	no
3d_25C	7d_25C	0.674016	no
3d_25C	7d_15C	0.459171	no
3d_25C	7d_30C	0.009124	yes
3d_25C	10d_25C	0.003625	yes
5d_25C	7d_25C	0.987140	no
5d_25C	7d_15C	0.809623	no
5d_25C	7d_30C	0.001278	yes
5d_25C	10d_25C	0.025858	yes
7d_25C	7d_15C	0.828621	no
7d_25C	7d_30C	0.001804	yes
7d_25C	10d_25C	0.029770	yes
7d_15C	7d_30C	0.000700	yes
7d_15C	10d_25C	0.085512	no
7d_30C	10d_25C	0.000700	yes

Sequences

Type of sequence	Sequence
Locus	Download genbank file of locus The gene with 5 kb flanks (if sufficient flanking sequence is available). For use in cloning design programs. NOTE: features (genes or exons) that are only partially contained within the sequence are completely excluded.
Protein	>Pro_DTO377G3_2|g7926.t1 MSLPQRPGRPSPRREEARAFREPSQRRRRDIDSGTYSDDPTSHSHRHRRRHSSHRRAMDTDEERMDRSGDVRHKK RMVKPERRKDDRDQPNYHYRQRSNHMRIFPSTTGNDPLLDKRDEVETNSSRSMDMKSKGLYARGNINKPMERVPS RHRSKKKKRGSRRSRGVAEEKRREKAIEQSGPPELWPTYCVVLTFFIPDFLLKCCGMPQKEQRTAWREKIGLISI IMMIGAFVGFLTFGFTATVCASPPVRLKVNEVSSNYMIFHGKAYDLSGSKHPAVTGISANANVLYDLPHKYGGQD GSFFFQQVNGACKGLITATSDSDIPTNSDGDLGWYFPCAPFNQDGSSEPNTTVEYYVGWACHTSKAAREPFYTLH SEGDVYYTWEDTKNKSRNLAIYSGNVLDLDLLAWFDTSQVSYPKQFDELRKNPDVRGVDLTYYLQSGEEKKIGKC LAQIIKVGSIDTDTVGCIASKVVLYVSLIFILSIVGVKFAFALLFQWFLAPRFAAQTTSMASDARTRNQQIEDWS NDIYRPAPRMTEPTIPDRLSKRASFLPTTSRFSSPYNVNSSAGSKQKPLYVTMASQNSTSRLMPSSNPGTMYKLS HSGSGGTLSADNSRHNPGASRTSLVPTGQGQQDTGYATLSTDYEGLGPAGYIHEAVVPQPPPEWQPFGYPLAHSL CLITCYSEGEEGIRSTLDSIAMTDYPNSHKTILVICDGIIKGKGESFSTPDIVLGMLREPVVPEDEVEPYSYVAV ATGSKRHNMAKVYTGFYDYGHNSIIPADKQQRVPMMVIVKCGTPQESTQSKPGNRGKRDSQIILMSFLQKVMFDE RMTELEYEMFNGLWNVTGIAPDFYEVVLMVDADTKVFPDSLTHMVSAMVKDPEIMGLCGETKIANKTDSWVTMIQ VFEYFISHHQAKSFESVFGGVTCLPGCFTMYRIKAPKGGQNYWVPILANPDIVEHYSENVVDTLHKKNLLLLGED RYLTTLMLKTFPKRKQIFVPQAVCKTVVPDAFLVLLSQRRRWINSTVHNLFELVLVRDLCGTFCFSMQFVIFIEL IGTLVLPAAISFTVYVVVVSIVKKPVQVIPLVLLALVLGLPGVLIVVTAHRLVYVLWMLIYLLSLPIWNFVLPMY AFWKFDDFSWGDTRKTAGEKDKGHGDAEGEFDSTKITMKRWRDFEKDRRLRSAWSQPPTTDVHPSQYEPYSHY*
Coding	>Pro_DTO377G3_2|g7926.t1 ATGTCTTTGCCGCAGCGGCCAGGGAGACCCTCGCCTCGGCGTGAAGAAGCCCGCGCATTTCGCGAACCATCCCAG CGCCGTCGACGGGATATCGACTCGGGAACTTACAGCGACGACCCGACTTCCCACTCCCATCGGCATCGCCGCCGA CATTCCAGCCATCGGAGAGCAATGGACACGGACGAAGAACGCATGGACCGGAGCGGGGATGTGAGACACAAAAAG CGCATGGTCAAACCAGAGCGCAGGAAAGACGACCGTGACCAACCCAACTATCACTACCGTCAGCGATCAAATCAC ATGCGTATTTTTCCCTCGACGACGGGAAACGATCCGTTATTGGATAAGAGAGATGAGGTGGAGACGAACAGCTCG CGCAGCATGGACATGAAGAGCAAGGGTCTTTACGCGCGGGGTAATATCAACAAACCCATGGAGCGTGTCCCTAGC AGACATCGCTCGAAGAAGAAGAAGAGAGGCTCGCGAAGGTCAAGGGGCGTTGCGGAGGAAAAGAGACGTGAAAAG GCAATTGAGCAGAGTGGTCCGCCCGAGTTATGGCCTACATATTGTGTAGTTCTCACATTCTTCATCCCGGACTTT TTGCTGAAATGCTGTGGAATGCCACAGAAAGAGCAGCGCACTGCTTGGCGGGAGAAGATCGGCCTTATCAGCATC ATTATGATGATCGGTGCTTTTGTCGGTTTCCTGACTTTCGGTTTCACGGCTACAGTTTGTGCCTCGCCCCCGGTT CGATTGAAGGTCAACGAAGTCAGTTCCAACTACATGATCTTCCATGGAAAGGCATATGACTTGTCCGGTTCGAAA CACCCCGCTGTCACTGGTATCTCTGCCAATGCGAATGTTCTCTACGACTTACCACACAAGTATGGCGGACAAGAT GGCAGCTTCTTCTTCCAACAGGTCAACGGTGCGTGCAAGGGACTGATTACTGCCACGTCTGATAGCGATATTCCA ACAAACTCCGATGGAGATCTCGGTTGGTACTTCCCTTGTGCGCCCTTCAACCAGGATGGTTCGTCCGAACCGAAT ACGACTGTTGAATATTATGTGGGCTGGGCTTGTCATACCAGCAAGGCGGCCCGCGAGCCTTTCTATACCCTGCAC AGTGAAGGGGATGTGTACTACACCTGGGAGGATACAAAGAACAAGAGTCGAAATCTGGCCATATACTCCGGAAAT GTACTCGACCTCGATCTTCTCGCCTGGTTTGACACTAGCCAGGTGTCCTATCCCAAACAATTCGACGAGCTCCGC AAGAATCCTGATGTCCGCGGTGTTGATCTGACTTACTACCTGCAAAGCGGGGAGGAGAAGAAGATCGGCAAGTGC TTGGCGCAGATCATCAAAGTCGGCAGTATCGACACTGATACTGTTGGCTGTATCGCGTCAAAAGTGGTGCTATAC GTATCCCTGATCTTCATTCTCTCCATCGTGGGTGTCAAATTCGCCTTCGCCCTGCTCTTCCAGTGGTTCCTGGCA CCCAGGTTTGCCGCGCAGACCACGAGTATGGCCTCCGACGCTAGGACTCGCAATCAGCAGATCGAAGACTGGTCC AACGACATATATCGACCCGCTCCACGAATGACCGAACCCACCATTCCCGATCGCCTCAGCAAACGCGCCAGCTTC CTCCCGACCACTTCTCGTTTCTCCAGCCCGTATAATGTGAACAGCAGCGCTGGGAGCAAGCAAAAGCCGTTGTAT GTCACGATGGCTAGCCAGAACTCGACGTCTCGGCTCATGCCCAGCTCCAATCCTGGCACTATGTATAAGCTGAGC CACAGCGGGAGCGGGGGCACTCTGAGCGCTGACAATTCCCGGCATAATCCTGGTGCCAGTCGGACTAGCTTGGTT CCGACCGGCCAGGGTCAACAAGATACGGGTTATGCCACGCTATCGACGGATTACGAGGGCTTAGGTCCTGCTGGT TACATTCACGAGGCTGTTGTTCCGCAACCTCCGCCTGAATGGCAGCCATTCGGCTACCCTCTAGCCCACAGTCTT TGTCTGATTACTTGCTACTCTGAGGGTGAAGAGGGTATTCGGTCGACTTTAGATTCTATTGCCATGACCGACTAC CCGAACAGTCACAAAACGATCTTGGTCATTTGTGATGGTATCATTAAAGGTAAGGGAGAATCGTTTTCCACGCCA GACATTGTGCTAGGCATGCTCAGGGAGCCTGTTGTTCCCGAGGACGAGGTCGAGCCCTACTCCTACGTGGCTGTG GCTACTGGCTCCAAGCGACACAACATGGCCAAGGTCTACACTGGGTTCTACGACTACGGCCATAATTCGATCATC CCGGCGGATAAGCAGCAGCGCGTTCCCATGATGGTGATTGTCAAGTGCGGAACTCCTCAAGAGTCGACCCAGTCA AAGCCCGGTAACCGTGGCAAGCGAGACAGTCAGATCATTCTCATGTCTTTCCTCCAGAAGGTTATGTTCGACGAG CGCATGACGGAACTAGAGTACGAGATGTTCAATGGCCTGTGGAACGTCACAGGCATTGCCCCAGACTTCTACGAG GTTGTTCTCATGGTCGACGCCGATACAAAGGTGTTCCCAGACAGTTTGACCCACATGGTCTCGGCCATGGTCAAG GACCCAGAAATCATGGGTCTCTGTGGAGAAACTAAGATCGCCAACAAGACTGACAGCTGGGTAACAATGATCCAG GTCTTCGAGTACTTTATCTCCCATCACCAAGCGAAATCATTCGAATCCGTGTTCGGTGGTGTAACCTGTCTCCCT GGATGTTTCACCATGTACCGAATCAAAGCCCCCAAGGGCGGCCAGAACTACTGGGTGCCCATTCTCGCCAACCCA GATATCGTTGAACACTACTCGGAAAACGTCGTGGATACTCTACACAAGAAGAACCTGCTCCTTCTCGGTGAAGAT CGCTACCTGACCACCCTGATGCTCAAGACCTTCCCGAAACGCAAGCAGATCTTCGTCCCACAAGCCGTCTGCAAA ACAGTCGTGCCGGACGCATTCCTCGTCCTACTCTCCCAGCGCCGTCGCTGGATCAACAGTACCGTCCACAACCTA TTTGAACTCGTCCTTGTGCGCGACCTGTGCGGAACCTTCTGCTTCAGCATGCAATTCGTCATCTTCATCGAGCTT ATCGGAACCCTGGTTCTGCCCGCTGCTATCTCCTTCACCGTCTATGTCGTCGTCGTCTCCATCGTCAAGAAACCC GTCCAGGTCATTCCGCTGGTTCTGCTCGCTCTGGTCTTGGGTCTGCCGGGTGTGTTGATCGTGGTCACTGCACAC AGACTGGTCTATGTGCTCTGGATGCTGATCTACCTCCTCTCGCTTCCGATCTGGAACTTCGTTCTGCCCATGTAT GCGTTCTGGAAGTTCGACGATTTCAGTTGGGGTGATACCCGTAAGACTGCGGGCGAGAAGGATAAGGGACACGGC GATGCCGAGGGCGAGTTTGATAGTACGAAGATCACGATGAAGAGGTGGCGCGATTTCGAAAAAGATCGTCGTCTA CGAAGTGCCTGGTCACAGCCCCCTACAACGGATGTTCATCCATCGCAGTACGAGCCTTATTCACATTACTAA
Transcript	>Pro_DTO377G3_2|g7926.t1 ATGTCTTTGCCGCAGCGGCCAGGGAGACCCTCGCCTCGGCGTGAAGAAGCCCGCGCATTTCGCGAACCATCCCAG CGCCGTCGACGGGATATCGACTCGGGAACTTACAGCGACGACCCGACTTCCCACTCCCATCGGCATCGCCGCCGA CATTCCAGCCATCGGAGAGCAATGGACACGGACGAAGAACGCATGGACCGGAGCGGGGATGTGAGACACAAAAAG CGCATGGTCAAACCAGAGCGCAGGAAAGACGACCGTGACCAACCCAACTATCACTACCGTCAGCGATCAAATCAC ATGCGTATTTTTCCCTCGACGACGGGAAACGATCCGTTATTGGATAAGAGAGATGAGGTGGAGACGAACAGCTCG CGCAGCATGGACATGAAGAGCAAGGGTCTTTACGCGCGGGGTAATATCAACAAACCCATGGAGCGTGTCCCTAGC AGACATCGCTCGAAGAAGAAGAAGAGAGGCTCGCGAAGGTCAAGGGGCGTTGCGGAGGAAAAGAGACGTGAAAAG GCAATTGAGCAGAGTGGTCCGCCCGAGTTATGGCCTACATATTGTGTAGTTCTCACATTCTTCATCCCGGACTTT TTGCTGAAATGCTGTGGAATGCCACAGAAAGAGCAGCGCACTGCTTGGCGGGAGAAGATCGGCCTTATCAGCATC ATTATGATGATCGGTGCTTTTGTCGGTTTCCTGACTTTCGGTTTCACGGCTACAGTTTGTGCCTCGCCCCCGGTT CGATTGAAGGTCAACGAAGTCAGTTCCAACTACATGATCTTCCATGGAAAGGCATATGACTTGTCCGGTTCGAAA CACCCCGCTGTCACTGGTATCTCTGCCAATGCGAATGTTCTCTACGACTTACCACACAAGTATGGCGGACAAGAT GGCAGCTTCTTCTTCCAACAGGTCAACGGTGCGTGCAAGGGACTGATTACTGCCACGTCTGATAGCGATATTCCA ACAAACTCCGATGGAGATCTCGGTTGGTACTTCCCTTGTGCGCCCTTCAACCAGGATGGTTCGTCCGAACCGAAT ACGACTGTTGAATATTATGTGGGCTGGGCTTGTCATACCAGCAAGGCGGCCCGCGAGCCTTTCTATACCCTGCAC AGTGAAGGGGATGTGTACTACACCTGGGAGGATACAAAGAACAAGAGTCGAAATCTGGCCATATACTCCGGAAAT GTACTCGACCTCGATCTTCTCGCCTGGTTTGACACTAGCCAGGTGTCCTATCCCAAACAATTCGACGAGCTCCGC AAGAATCCTGATGTCCGCGGTGTTGATCTGACTTACTACCTGCAAAGCGGGGAGGAGAAGAAGATCGGCAAGTGC TTGGCGCAGATCATCAAAGTCGGCAGTATCGACACTGATACTGTTGGCTGTATCGCGTCAAAAGTGGTGCTATAC GTATCCCTGATCTTCATTCTCTCCATCGTGGGTGTCAAATTCGCCTTCGCCCTGCTCTTCCAGTGGTTCCTGGCA CCCAGGTTTGCCGCGCAGACCACGAGTATGGCCTCCGACGCTAGGACTCGCAATCAGCAGATCGAAGACTGGTCC AACGACATATATCGACCCGCTCCACGAATGACCGAACCCACCATTCCCGATCGCCTCAGCAAACGCGCCAGCTTC CTCCCGACCACTTCTCGTTTCTCCAGCCCGTATAATGTGAACAGCAGCGCTGGGAGCAAGCAAAAGCCGTTGTAT GTCACGATGGCTAGCCAGAACTCGACGTCTCGGCTCATGCCCAGCTCCAATCCTGGCACTATGTATAAGCTGAGC CACAGCGGGAGCGGGGGCACTCTGAGCGCTGACAATTCCCGGCATAATCCTGGTGCCAGTCGGACTAGCTTGGTT CCGACCGGCCAGGGTCAACAAGATACGGGTTATGCCACGCTATCGACGGATTACGAGGGCTTAGGTCCTGCTGGT TACATTCACGAGGCTGTTGTTCCGCAACCTCCGCCTGAATGGCAGCCATTCGGCTACCCTCTAGCCCACAGTCTT TGTCTGATTACTTGCTACTCTGAGGGTGAAGAGGGTATTCGGTCGACTTTAGATTCTATTGCCATGACCGACTAC CCGAACAGTCACAAAACGATCTTGGTCATTTGTGATGGTATCATTAAAGGTAAGGGAGAATCGTTTTCCACGCCA GACATTGTGCTAGGCATGCTCAGGGAGCCTGTTGTTCCCGAGGACGAGGTCGAGCCCTACTCCTACGTGGCTGTG GCTACTGGCTCCAAGCGACACAACATGGCCAAGGTCTACACTGGGTTCTACGACTACGGCCATAATTCGATCATC CCGGCGGATAAGCAGCAGCGCGTTCCCATGATGGTGATTGTCAAGTGCGGAACTCCTCAAGAGTCGACCCAGTCA AAGCCCGGTAACCGTGGCAAGCGAGACAGTCAGATCATTCTCATGTCTTTCCTCCAGAAGGTTATGTTCGACGAG CGCATGACGGAACTAGAGTACGAGATGTTCAATGGCCTGTGGAACGTCACAGGCATTGCCCCAGACTTCTACGAG GTTGTTCTCATGGTCGACGCCGATACAAAGGTGTTCCCAGACAGTTTGACCCACATGGTCTCGGCCATGGTCAAG GACCCAGAAATCATGGGTCTCTGTGGAGAAACTAAGATCGCCAACAAGACTGACAGCTGGGTAACAATGATCCAG GTCTTCGAGTACTTTATCTCCCATCACCAAGCGAAATCATTCGAATCCGTGTTCGGTGGTGTAACCTGTCTCCCT GGATGTTTCACCATGTACCGAATCAAAGCCCCCAAGGGCGGCCAGAACTACTGGGTGCCCATTCTCGCCAACCCA GATATCGTTGAACACTACTCGGAAAACGTCGTGGATACTCTACACAAGAAGAACCTGCTCCTTCTCGGTGAAGAT CGCTACCTGACCACCCTGATGCTCAAGACCTTCCCGAAACGCAAGCAGATCTTCGTCCCACAAGCCGTCTGCAAA ACAGTCGTGCCGGACGCATTCCTCGTCCTACTCTCCCAGCGCCGTCGCTGGATCAACAGTACCGTCCACAACCTA TTTGAACTCGTCCTTGTGCGCGACCTGTGCGGAACCTTCTGCTTCAGCATGCAATTCGTCATCTTCATCGAGCTT ATCGGAACCCTGGTTCTGCCCGCTGCTATCTCCTTCACCGTCTATGTCGTCGTCGTCTCCATCGTCAAGAAACCC GTCCAGGTCATTCCGCTGGTTCTGCTCGCTCTGGTCTTGGGTCTGCCGGGTGTGTTGATCGTGGTCACTGCACAC AGACTGGTCTATGTGCTCTGGATGCTGATCTACCTCCTCTCGCTTCCGATCTGGAACTTCGTTCTGCCCATGTAT GCGTTCTGGAAGTTCGACGATTTCAGTTGGGGTGATACCCGTAAGACTGCGGGCGAGAAGGATAAGGGACACGGC GATGCCGAGGGCGAGTTTGATAGTACGAAGATCACGATGAAGAGGTGGCGCGATTTCGAAAAAGATCGTCGTCTA CGAAGTGCCTGGTCACAGCCCCCTACAACGGATGTTCATCCATCGCAGTACGAGCCTTATTCACATTACTAA
Gene	>Pro_DTO377G3_2|g7926.t1 ATGTCTTTGCCGCAGCGGCCAGGGAGACCCTCGCCTCGGCGTGAAGAAGCCCGCGCATTTCGCGAACCATCCCAG CGCCGTCGACGGGATATCGACTCGGGAACTTACAGCGACGACCCGACTTCCCACTCCCATCGGCATCGCCGCCGA CATTCCAGCCATCGGAGAGCAATGGACACGGACGAAGAACGCATGGACCGGAGCGGGGATGTGAGACACAAAAAG CGCATGGTCAAACCAGAGCGCAGGAAAGACGACCGTGACCAACCCAACTATCACTACCGTCAGCGATCAAATCAC ATGCGTATTTTTCCCTCGACGACGGGAAACGATCCGTTATTGGATAAGAGAGATGAGGTGGAGACGAACAGCTCG CGCAGCATGGACATGAAGAGCAAGGGTCTTTACGCGCGGGGTAATATCAACAAACCCATGGAGCGTGTCCCTAGC AGACATCGCTCGAAGAAGAAGAAGAGAGGCTCGCGAAGGTCAAGGGGCGTTGCGGAGGAAAAGAGACGTGAAAAG GCAATTGAGCAGAGTGGTCCGCCCGAGTTATGGCCTACATATTGTGTAGTTCTCACATTCTTCATCCCGGACTTT TTGCTGAAATGCTGTGGAATGCCACAGAAAGAGCAGCGCACTGCTTGGCGGGAGAAGATCGGCCTTATCAGCATC ATTATGATGATCGGTGCTTTTGTCGGTTTCCTGACTTTCGGTTTCACGGCTACAGTTTGTGCCTCGCCCCCGGTT CGATTGAAGGTCAACGAAGTCAGTTCCAACTACATGATCTTCCATGGAAAGGCATATGACTTGTCCGGTTCGAAA CACCCCGCTGTCACTGGTATCTCTGCCAATGCGAATGTTCTCTACGACTTACCACACAAGTATGGCGGACAAGAT GGCAGCTTCTTCTTCCAACAGGTCAACGGTGCGTGCAAGGGACTGATTACTGCCACGTCTGATAGCGATATTCCA ACAAACTCCGATGGAGATCTCGGTTGGTACTTCCCTTGTGCGCCCTTCAACCAGGATGGTTCGTCCGAACCGAAT ACGACTGTTGAATATTATGTGGGCTGGGCTTGTCATACCAGCAAGGCGGCCCGCGAGCCTTTCTATACCCTGCAC AGTGAAGGGGATGTGTACTACACCTGGGAGGATACAAAGAACAAGAGTCGAAATCTGGCCATATACTCCGGAAAT GTACTCGACCTCGATCTTCTCGCCTGGTTTGACACTAGCCAGGTGTCCTATCCCAAACAATTCGACGAGCTCCGC AAGAATCCTGATGTCCGCGGTGTTGATCTGACTTACTACCTGCAAAGCGGGGAGGAGAAGAAGATCGGCAAGTGC TTGGCGCAGATCATCAAAGTCGGCAGTATCGACACTGATACTGTTGGCTGTATCGCGTCAAAAGTGGTGCTATAC GTATCCCTGATCTTCATTCTCTCCATCGTGGGTGTCAAATTCGCCTTCGCCCTGCTCTTCCAGTGGTTCCTGGCA CCCAGGTTTGCCGCGCAGACCACGAGTATGGCCTCCGACGCTAGGACTCGCAATCAGCAGATCGAAGACTGGTCC AACGACATATATCGACCCGCTCCACGAATGACCGAACCCACCATTCCCGATCGCCTCAGCAAACGCGCCAGCTTC CTCCCGACCACTTCTCGTTTCTCCAGCCCGTATAATGTGAACAGCAGCGCTGGGAGCAAGCAAAAGCCGTTGTAT GTCACGATGGCTAGCCAGAACTCGACGTCTCGGCTCATGCCCAGCTCCAATCCTGGCACTATGTATAAGCTGAGC CACAGCGGGAGCGGGGGCACTCTGAGCGCTGACAATTCCCGGCATAATCCTGGTGCCAGTCGGACTAGCTTGGTT CCGACCGGCCAGGGTCAACAAGATACGGGTTATGCCACGCTATCGACGGATTACGAGGGCTTAGGTCCTGCTGGT TACATTCACGAGGCTGTTGTTCCGCAACCTCCGCCTGAATGGCAGCCATTCGGCTACCCTCTAGCCCACAGTCTT TGTCTGATTACTTGCTACTCTGAGGGTGAAGAGGGTATTCGGTCGACTTTAGATTCTATTGCCATGACCGACTAC CCGAACAGTCACAAAACGATCTTGGTCATTTGTGATGGTATCATTAAAGGTAAGGGAGAATCGTTTTCCACGCCA GACATTGTGCTAGGCATGCTCAGGGAGCCTGTTGTTCCCGAGGACGAGGTCGAGCCCTACTCCTACGTGGCTGTG GCTACTGGCTCCAAGCGACACAACATGGCCAAGGTCTACACTGGGTTCTACGACTACGGCCATAATTCGATCATC CCGGCGGATAAGCAGCAGCGCGTTCCCATGATGGTGATTGTCAAGTGCGGAACTCCTCAAGAGTCGACCCAGTCA AAGCCCGGTAACCGTGGCAAGCGAGACAGTCAGATCATTCTCATGTCTTTCCTCCAGAAGGTTATGTTCGACGAG CGCATGACGGAACTAGAGTACGAGATGTTCAATGGCCTGTGGAACGTCACAGGCATTGCCCCAGACTTCTACGAG GTTGTTCTCATGGTCGACGCCGATACAAAGGTGTTCCCAGACAGTTTGACCCACATGGTCTCGGCCATGGTCAAG GACCCAGAAATCATGGGTCTCTGTGGAGAAACTAAGATCGCCAACAAGACTGACAGCTGGGTAACAATGATCCAG GTCTTCGAGTAAGTCTCCACTGTCCATTAGCAGCGCAGTAACTAATTCAAAACAGGTACTTTATCTCCCATCACC AAGCGAAATCATTCGAATCCGTGTTCGGTGGTGTAACCTGTCTCCCTGGATGTTTCACCATGTACCGAATCAAAG CCCCCAAGGGCGGCCAGAACTACTGGGTGCCCATTCTCGCCAACCCAGATATCGTTGAACACTACTCGGAAAACG TCGTGGATACTCTACACAAGAAGAACCTGCTCCTTCTCGGTGAAGATCGCTACCTGACCACCCTGATGCTCAAGA CCTTCCCGAAACGCAAGCAGATCTTCGTCCCACAAGCCGTCTGCAAAACAGTCGTGCCGGACGCATTCCTCGTCC TACTCTCCCAGCGCCGTCGCTGGATCAACAGTACCGTCCACAACCTATTTGAACTCGTCCTTGTGCGCGACCTGT GCGGAACCTTCTGCTTCAGCATGCAATTCGTCATCTTCATCGAGCTTATCGGAACCCTGGTTCTGCCCGCTGCTA TCTCCTTCACCGTCTATGTCGTCGTCGTCTCCATCGTCAAGAAACCCGTCCAGGTCATTCCGCTGGTTCTGCTCG CTCTGGTCTTGGGTCTGCCGGGTGTGTTGATCGTGGTCACTGCACACAGACTGGTCTATGTGCTCTGGATGCTGA TCTACCTCCTCTCGCTTCCGATCTGGAACTTCGTTCTGCCCATGTATGCGTTCTGGAAGTTCGACGATTTCAGTT GGGGTGATACCCGTAAGACTGCGGGCGAGAAGGATAAGGGACACGGCGATGCCGAGGGCGAGTTTGATAGTACGA AGATCACGATGAAGAGGTGGCGCGATTTCGAAAAAGGTATGTCTTAGGTTGCCCTGGAATGATTTGTCGATTCTA ATATTCTCGATAGATCGTCGTCTACGAAGTGCCTGGTCACAGCCCCCTACAACGGATGTTCATCCATCGCAGTAC GAGCCTTATTCACATTACTAA