Fungal Genomics

Agaricus bisporus var bisporus H39 Agaricus bisporus var bisporus H97 Agaricus bisporus var burnettii H119p4 Aspergillus niger CBS 112.32 Aspergillus niger CBS 113.50 Aspergillus niger CBS 115988 Aspergillus niger CBS 115989 Aspergillus niger CBS 118.52 Aspergillus niger CBS 124.48 Aspergillus niger CBS 131.52 Aspergillus niger CBS 133816 Aspergillus niger CBS 147320 Aspergillus niger CBS 147321 Aspergillus niger CBS 147322 Aspergillus niger CBS 147323 Aspergillus niger CBS 147324 Aspergillus niger CBS 147343 Aspergillus niger CBS 147344 Aspergillus niger CBS 147345 Aspergillus niger CBS 147346 Aspergillus niger CBS 147347 Aspergillus niger CBS 147352 Aspergillus niger CBS 147353 Aspergillus niger CBS 147371 Aspergillus niger CBS 147482 Aspergillus niger CBS 630.78 Aspergillus niger CBS 769.97 Ophiocordyceps australis 1348a (Ghana) Ophiocordyceps australis map64 (Brazil) Ophiocordyceps camponoti-floridani Ophiocordyceps camponoti-rufipedis Ophiocordyceps kimflemingae Ophiocordyceps subramaniannii Penicillium roqueforti DTO002I6 Penicillium roqueforti DTO003C3 Penicillium roqueforti DTO003H1 (CBS 147308) Penicillium roqueforti DTO006G1 Penicillium roqueforti DTO006G7 Penicillium roqueforti DTO012A1 Penicillium roqueforti DTO012A2 (CBS 147309) Penicillium roqueforti DTO012A6 (CBS 147310) Penicillium roqueforti DTO012A7 Penicillium roqueforti DTO012A8 Penicillium roqueforti DTO012A9 Penicillium roqueforti DTO013E5 Penicillium roqueforti DTO013F2 Penicillium roqueforti DTO013F5 (CBS 147311) Penicillium roqueforti DTO027I6 Penicillium roqueforti DTO032C6 Penicillium roqueforti DTO039G3 Penicillium roqueforti DTO046C5 Penicillium roqueforti DTO070G2 (CBS 147317) Penicillium roqueforti DTO081F9 (CBS 147318) Penicillium roqueforti DTO101D6 (CBS 147325) Penicillium roqueforti DTO102I9 (CBS 147326) Penicillium roqueforti DTO126G2 (CBS 147330) Penicillium roqueforti DTO127F7 (CBS 147331) Penicillium roqueforti DTO127F9 (CBS 147332) Penicillium roqueforti DTO130C1 (CBS 147333) Penicillium roqueforti DTO163C3 (CBS 147337) Penicillium roqueforti DTO163F5 (CBS 147338) Penicillium roqueforti DTO163G4 (CBS 147339) Penicillium roqueforti DTO265D5 (CBS 147372) Penicillium roqueforti DTO369A1 (CBS 147354) Penicillium roqueforti DTO375B1 (CBS 147355) Penicillium roqueforti DTO377G2 (LCP 96.3914a) Penicillium roqueforti LCP96 04111 Rhodonia placenta FPRL280

General Properties

Protein ID	Pro_DTO377G3_2|g6313.t1
Gene name
Location	scaffold_16:495287..499756
Strand	+
Gene length (bp)	4469
Transcript length (bp)	3237
Coding sequence length (bp)	3237
Protein length (aa)	1079

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PFAM Domains

PFAM Domain ID	Short name	Long name	E-value	Start	End
PF11815	DUF3336	Domain of unknown function (DUF3336)	7.0E-36	369	486
PF03006	HlyIII	Haemolysin-III related	8.9E-33	71	277
PF01734	Patatin	Patatin-like phospholipase	1.7E-21	517	705

GO

GO Term	Description	Terminal node
GO:0006629	lipid metabolic process	Yes
GO:0016021	integral component of membrane	Yes
GO:0004806	triglyceride lipase activity	Yes
GO:0008150	biological_process	No
GO:0044238	primary metabolic process	No
GO:0016298	lipase activity	No
GO:0016788	hydrolase activity, acting on ester bonds	No
GO:0110165	cellular anatomical entity	No
GO:0008152	metabolic process	No
GO:0005575	cellular_component	No
GO:0031224	intrinsic component of membrane	No
GO:0052689	carboxylic ester hydrolase activity	No
GO:0003674	molecular_function	No
GO:0003824	catalytic activity	No
GO:0016787	hydrolase activity	No
GO:0071704	organic substance metabolic process	No

SignalP

[Help with interpreting these statistics]

SignalP signal predicted	Location (based on Ymax)	D score (significance: > 0.45)
No	1 - 23	0.45

Transmembrane Domains

Domain #	Start	End	Length
1	84	106	22
2	113	135	22
3	150	172	22
4	179	201	22
5	211	233	22
6	240	262	22

Transcription Factor Class

(None)

Expression data

Analysis 1: Genome-wide gene expression in conidia of Penicillium roqueforti during growth at various temperatures and for various amounts of time. Published in Punt et al., 2020.

Expression values

Label	Description	Expression (RPKM)	Confidence interval (low)	Confidence interval (high)
3d_25C	Three days - 25 degrees Celsius	32.85	19.97	45.73
5d_25C	Five days - 25 degrees Celsius	39.88	24.30	55.46
7d_25C	Seven days - 25 degrees Celsius	42.51	25.90	59.12
10d_25C	Ten days - 25 degrees Celsius	54.36	33.07	75.65
7d_15C	Seven days - 15 degrees Celsius	50.30	30.29	70.31
7d_30C	Seven days - 30 degrees Celsius	39.77	24.44	55.10

Differential expression

Label1	Label2	Q-value	Significant difference
3d_25C	5d_25C	0.440632	no
3d_25C	7d_25C	0.274534	no
3d_25C	7d_15C	0.048064	yes
3d_25C	7d_30C	0.440026	no
3d_25C	10d_25C	0.017204	yes
5d_25C	7d_25C	0.836827	no
5d_25C	7d_15C	0.330124	no
5d_25C	7d_30C	0.993328	no
5d_25C	10d_25C	0.158622	no
7d_25C	7d_15C	0.517162	no
7d_25C	7d_30C	0.830579	no
7d_25C	10d_25C	0.290868	no
7d_15C	7d_30C	0.320184	no
7d_15C	10d_25C	0.800009	no
7d_30C	10d_25C	0.148751	no

Sequences

Type of sequence	Sequence
Locus	Download genbank file of locus The gene with 5 kb flanks (if sufficient flanking sequence is available). For use in cloning design programs. NOTE: features (genes or exons) that are only partially contained within the sequence are completely excluded.
Protein	>Pro_DTO377G3_2|g6313.t1 MSSLRLAMTSLLTGLRPEVVEKLQSDKTGFPQKQHVFHASDVPKWMQWDPFIQRGYRTQLNSFKRCFWSLFYLHN ESINTWSHVLAGIYFLAVLLATDYWIAQLGLKVPLSDILAIQTYVAGTAGCLIFSATFHATNAHSPEVAHAFLKL DYFGIVLTISTTCISVAYFALHGEPRLQCVYIFFTVLCAAMVFCITLDVGMDGTRAGPWRATVFTLLAASGLAPI FHVISSGSPRDFIRIPWETLIVTCSSYAIGTVAYLFRFPERYWPAQFDIIISAFHTPAEWLASLMHRPTMSVLGD PTLVQCHHGRKHSQEYSLPQPLPPRPLCKTISIPTVSSLVKDSWNWAGDTLHTYRDGLSKEQRKQRADIEDRKQV LYLKIKNAVSYEEWRSCASELDELEDNNAWKQTLECTEYDPRLVQDRLRQLEEARISCDVSRMLFLVRTALSRDL AHMSNASLYRHSHIGTKDLIDRYITTALDTIATLVDLSVHDRCDGLELKYILDQLLAARQAFGRSALLFSGGATF GMTHIGVLKALYEAKMIPRIISGASAGSIVCAVFCTRTDEELPALLDTYVHGDFDVFNEKGQEENILQKMTRFLK FGSFFDISHLAKTIRNWLGDMTFQEAYNRTRRILNICVSSAGMYELPRLLNYISAPNVLIWSAVAVSCSVPFVFR PFTLMAKDPLTGEPVPWNDLHKQYIDGSVDGDLPMTRLSEMFNVNHFIVSQVNPHVVPFLPKETGPQDATNDGPS FIPRWMNMMAHLAKDEVLHRMNVLSELGVFPTSMTKFASIVNQKYHGDINIYPELLSSNLPRLLENPTTEFMLSS CLSGERATWPRLSRIRNHCAIELALDNAIQNMRARVAFSPSQVDLRMPHRSRHSIDSADSNGRGRYRDRRRGSHS PEFEKRQSGGQELRRPDHELRKERSTVSLENPPLSQSSESIFMPTQTRTHRRTSSVFFSNGGMFDIGSSSDDELE RSYMLRPKLAGHRTFSESSSFGRVAPSHGPRSPVRSRRSSLSSNPAYNFSSTARRSSPKQVYTPSARDFSVTIPP SSRHLLSMTPTPTLLPSSPEPLTRKRQN*
Coding	>Pro_DTO377G3_2|g6313.t1 ATGTCTTCTCTCCGTCTAGCAATGACCAGTCTGTTAACCGGGTTGCGCCCAGAGGTGGTGGAAAAACTTCAGTCG GACAAGACTGGCTTTCCTCAAAAGCAACATGTCTTCCATGCATCCGACGTTCCTAAATGGATGCAATGGGACCCG TTTATCCAACGAGGATACCGAACCCAGCTGAATAGTTTCAAGCGGTGTTTCTGGTCCCTATTCTATCTACATAAT GAATCAATCAACACCTGGTCACACGTCCTTGCAGGAATTTATTTCCTCGCCGTTCTTCTCGCCACCGACTATTGG ATCGCCCAACTGGGACTCAAAGTGCCATTATCAGACATACTTGCTATTCAGACGTATGTTGCCGGCACTGCAGGG TGTCTCATATTCTCCGCTACCTTCCACGCAACCAACGCTCATTCGCCTGAAGTCGCTCATGCCTTCCTCAAACTA GATTACTTCGGAATTGTGCTCACCATCTCAACTACATGTATCTCAGTCGCTTATTTCGCCCTGCACGGAGAACCG AGGCTCCAATGCGTCTACATTTTCTTCACTGTTCTCTGCGCAGCTATGGTCTTCTGTATCACACTTGATGTCGGT ATGGATGGTACACGTGCTGGTCCATGGAGAGCAACTGTATTCACCCTTCTTGCGGCTAGCGGCCTAGCCCCTATC TTCCACGTCATCTCGAGCGGTTCCCCTCGCGATTTCATCCGCATCCCTTGGGAGACTCTCATAGTAACCTGTTCT TCATACGCAATTGGCACAGTGGCGTATCTCTTCCGGTTTCCAGAGCGGTATTGGCCGGCGCAATTTGATATTATC ATCTCCGCATTTCACACCCCGGCTGAATGGCTTGCTTCTCTAATGCACAGGCCTACCATGTCGGTGTTGGGCGAC CCCACATTAGTTCAGTGCCATCATGGGCGCAAACACTCCCAAGAATACTCTTTACCCCAACCCTTACCTCCGCGA CCGCTCTGCAAAACGATCTCCATCCCAACCGTATCGTCGCTCGTGAAGGATTCGTGGAATTGGGCCGGTGATACT CTGCACACCTACCGTGATGGTCTCTCGAAGGAACAACGGAAACAAAGGGCGGACATCGAGGACCGCAAGCAAGTC CTGTATCTGAAAATAAAGAATGCTGTGTCGTACGAAGAATGGCGAAGTTGCGCCAGTGAACTGGACGAACTAGAG GATAACAACGCTTGGAAGCAGACACTCGAGTGCACCGAATATGATCCTCGTTTGGTACAGGATCGTTTGCGACAG TTGGAAGAGGCTCGCATCAGCTGTGATGTAAGCCGGATGTTGTTCTTGGTGCGTACTGCGCTGAGTCGGGACCTG GCGCATATGAGCAATGCCTCTCTCTATCGCCATTCGCATATTGGTACAAAGGACTTGATCGATAGGTATATCACC ACGGCTTTGGATACTATCGCTACGCTGGTGGATCTCTCGGTGCATGATCGCTGTGATGGGTTGGAGCTGAAGTAT ATCCTGGACCAGCTCCTGGCAGCTCGACAGGCATTTGGTCGCAGTGCTCTCCTTTTCTCCGGTGGTGCCACTTTT GGCATGACCCATATCGGGGTTCTCAAGGCCCTCTATGAAGCAAAAATGATTCCGCGAATTATCTCAGGTGCCTCG GCTGGTAGCATTGTGTGCGCGGTATTTTGCACGCGCACAGACGAAGAGCTTCCGGCGCTTTTGGATACCTATGTA CATGGGGATTTCGACGTTTTCAATGAAAAGGGCCAAGAGGAAAATATCTTGCAGAAGATGACTCGTTTTTTGAAG TTTGGATCATTTTTTGACATATCTCACTTGGCGAAGACTATCAGAAACTGGCTGGGGGATATGACTTTTCAGGAA GCATATAACCGCACCCGCAGAATCCTAAATATCTGTGTGTCAAGTGCCGGCATGTATGAGCTTCCACGGCTGTTG AACTATATTTCTGCTCCCAATGTGTTGATCTGGTCTGCTGTCGCGGTATCATGCTCTGTTCCTTTTGTCTTTAGG CCATTCACGTTGATGGCTAAAGATCCGTTGACAGGGGAACCGGTCCCCTGGAATGATCTTCACAAGCAGTATATT GATGGCTCGGTCGATGGAGATTTACCCATGACACGCTTATCGGAGATGTTTAACGTGAATCACTTTATAGTCTCC CAAGTGAACCCCCATGTGGTTCCATTTCTTCCAAAGGAAACAGGCCCACAGGATGCGACAAACGACGGCCCTTCG TTCATTCCTCGATGGATGAACATGATGGCGCACCTTGCCAAAGACGAGGTTCTGCATCGGATGAACGTCCTCTCA GAACTTGGAGTCTTTCCAACATCAATGACCAAGTTTGCCTCTATTGTGAACCAGAAATATCATGGAGACATCAAC ATATACCCAGAACTCCTTTCCTCTAACCTCCCAAGGCTCCTGGAGAATCCCACAACGGAGTTCATGCTTTCGTCA TGCCTGAGTGGCGAGCGGGCGACATGGCCGAGACTAAGCCGTATCCGAAACCACTGCGCCATTGAGCTGGCACTC GATAATGCAATTCAAAATATGCGGGCCCGGGTGGCCTTCAGTCCAAGTCAGGTTGATCTACGTATGCCGCACCGT AGTCGTCACTCGATTGACTCGGCAGACAGCAACGGAAGGGGACGTTATCGGGACAGGCGAAGAGGGTCCCACAGC CCCGAATTTGAAAAGAGGCAGTCGGGTGGGCAGGAACTACGTCGGCCAGATCACGAACTGAGAAAGGAACGAAGC ACTGTTTCGTTAGAGAACCCGCCTCTCTCGCAATCAAGCGAGTCAATCTTCATGCCAACCCAAACAAGGACCCAC CGCCGTACATCCTCAGTATTCTTCAGCAATGGAGGGATGTTCGATATTGGGTCAAGCAGCGATGACGAGCTCGAA CGATCATACATGCTTCGTCCCAAACTCGCAGGCCACCGAACGTTCTCAGAGTCATCTTCGTTTGGCAGAGTAGCT CCGAGTCACGGGCCCCGCAGCCCTGTCCGGTCCCGACGATCATCATTATCCTCTAACCCGGCCTATAATTTCTCC TCCACGGCTCGTCGCAGTTCCCCAAAGCAGGTTTATACGCCGTCGGCTCGCGATTTCTCCGTGACCATACCACCT TCATCCCGCCATCTGCTCAGTATGACTCCAACGCCAACACTCCTTCCGAGCTCGCCTGAGCCCCTCACGCGCAAG CGGCAGAATTGA
Transcript	>Pro_DTO377G3_2|g6313.t1 ATGTCTTCTCTCCGTCTAGCAATGACCAGTCTGTTAACCGGGTTGCGCCCAGAGGTGGTGGAAAAACTTCAGTCG GACAAGACTGGCTTTCCTCAAAAGCAACATGTCTTCCATGCATCCGACGTTCCTAAATGGATGCAATGGGACCCG TTTATCCAACGAGGATACCGAACCCAGCTGAATAGTTTCAAGCGGTGTTTCTGGTCCCTATTCTATCTACATAAT GAATCAATCAACACCTGGTCACACGTCCTTGCAGGAATTTATTTCCTCGCCGTTCTTCTCGCCACCGACTATTGG ATCGCCCAACTGGGACTCAAAGTGCCATTATCAGACATACTTGCTATTCAGACGTATGTTGCCGGCACTGCAGGG TGTCTCATATTCTCCGCTACCTTCCACGCAACCAACGCTCATTCGCCTGAAGTCGCTCATGCCTTCCTCAAACTA GATTACTTCGGAATTGTGCTCACCATCTCAACTACATGTATCTCAGTCGCTTATTTCGCCCTGCACGGAGAACCG AGGCTCCAATGCGTCTACATTTTCTTCACTGTTCTCTGCGCAGCTATGGTCTTCTGTATCACACTTGATGTCGGT ATGGATGGTACACGTGCTGGTCCATGGAGAGCAACTGTATTCACCCTTCTTGCGGCTAGCGGCCTAGCCCCTATC TTCCACGTCATCTCGAGCGGTTCCCCTCGCGATTTCATCCGCATCCCTTGGGAGACTCTCATAGTAACCTGTTCT TCATACGCAATTGGCACAGTGGCGTATCTCTTCCGGTTTCCAGAGCGGTATTGGCCGGCGCAATTTGATATTATC ATCTCCGCATTTCACACCCCGGCTGAATGGCTTGCTTCTCTAATGCACAGGCCTACCATGTCGGTGTTGGGCGAC CCCACATTAGTTCAGTGCCATCATGGGCGCAAACACTCCCAAGAATACTCTTTACCCCAACCCTTACCTCCGCGA CCGCTCTGCAAAACGATCTCCATCCCAACCGTATCGTCGCTCGTGAAGGATTCGTGGAATTGGGCCGGTGATACT CTGCACACCTACCGTGATGGTCTCTCGAAGGAACAACGGAAACAAAGGGCGGACATCGAGGACCGCAAGCAAGTC CTGTATCTGAAAATAAAGAATGCTGTGTCGTACGAAGAATGGCGAAGTTGCGCCAGTGAACTGGACGAACTAGAG GATAACAACGCTTGGAAGCAGACACTCGAGTGCACCGAATATGATCCTCGTTTGGTACAGGATCGTTTGCGACAG TTGGAAGAGGCTCGCATCAGCTGTGATGTAAGCCGGATGTTGTTCTTGGTGCGTACTGCGCTGAGTCGGGACCTG GCGCATATGAGCAATGCCTCTCTCTATCGCCATTCGCATATTGGTACAAAGGACTTGATCGATAGGTATATCACC ACGGCTTTGGATACTATCGCTACGCTGGTGGATCTCTCGGTGCATGATCGCTGTGATGGGTTGGAGCTGAAGTAT ATCCTGGACCAGCTCCTGGCAGCTCGACAGGCATTTGGTCGCAGTGCTCTCCTTTTCTCCGGTGGTGCCACTTTT GGCATGACCCATATCGGGGTTCTCAAGGCCCTCTATGAAGCAAAAATGATTCCGCGAATTATCTCAGGTGCCTCG GCTGGTAGCATTGTGTGCGCGGTATTTTGCACGCGCACAGACGAAGAGCTTCCGGCGCTTTTGGATACCTATGTA CATGGGGATTTCGACGTTTTCAATGAAAAGGGCCAAGAGGAAAATATCTTGCAGAAGATGACTCGTTTTTTGAAG TTTGGATCATTTTTTGACATATCTCACTTGGCGAAGACTATCAGAAACTGGCTGGGGGATATGACTTTTCAGGAA GCATATAACCGCACCCGCAGAATCCTAAATATCTGTGTGTCAAGTGCCGGCATGTATGAGCTTCCACGGCTGTTG AACTATATTTCTGCTCCCAATGTGTTGATCTGGTCTGCTGTCGCGGTATCATGCTCTGTTCCTTTTGTCTTTAGG CCATTCACGTTGATGGCTAAAGATCCGTTGACAGGGGAACCGGTCCCCTGGAATGATCTTCACAAGCAGTATATT GATGGCTCGGTCGATGGAGATTTACCCATGACACGCTTATCGGAGATGTTTAACGTGAATCACTTTATAGTCTCC CAAGTGAACCCCCATGTGGTTCCATTTCTTCCAAAGGAAACAGGCCCACAGGATGCGACAAACGACGGCCCTTCG TTCATTCCTCGATGGATGAACATGATGGCGCACCTTGCCAAAGACGAGGTTCTGCATCGGATGAACGTCCTCTCA GAACTTGGAGTCTTTCCAACATCAATGACCAAGTTTGCCTCTATTGTGAACCAGAAATATCATGGAGACATCAAC ATATACCCAGAACTCCTTTCCTCTAACCTCCCAAGGCTCCTGGAGAATCCCACAACGGAGTTCATGCTTTCGTCA TGCCTGAGTGGCGAGCGGGCGACATGGCCGAGACTAAGCCGTATCCGAAACCACTGCGCCATTGAGCTGGCACTC GATAATGCAATTCAAAATATGCGGGCCCGGGTGGCCTTCAGTCCAAGTCAGGTTGATCTACGTATGCCGCACCGT AGTCGTCACTCGATTGACTCGGCAGACAGCAACGGAAGGGGACGTTATCGGGACAGGCGAAGAGGGTCCCACAGC CCCGAATTTGAAAAGAGGCAGTCGGGTGGGCAGGAACTACGTCGGCCAGATCACGAACTGAGAAAGGAACGAAGC ACTGTTTCGTTAGAGAACCCGCCTCTCTCGCAATCAAGCGAGTCAATCTTCATGCCAACCCAAACAAGGACCCAC CGCCGTACATCCTCAGTATTCTTCAGCAATGGAGGGATGTTCGATATTGGGTCAAGCAGCGATGACGAGCTCGAA CGATCATACATGCTTCGTCCCAAACTCGCAGGCCACCGAACGTTCTCAGAGTCATCTTCGTTTGGCAGAGTAGCT CCGAGTCACGGGCCCCGCAGCCCTGTCCGGTCCCGACGATCATCATTATCCTCTAACCCGGCCTATAATTTCTCC TCCACGGCTCGTCGCAGTTCCCCAAAGCAGGTTTATACGCCGTCGGCTCGCGATTTCTCCGTGACCATACCACCT TCATCCCGCCATCTGCTCAGTATGACTCCAACGCCAACACTCCTTCCGAGCTCGCCTGAGCCCCTCACGCGCAAG CGGCAGAATTGA
Gene	>Pro_DTO377G3_2|g6313.t1 ATGTCTTCTCTCCGTCTAGCAATGACCAGTCTGTTAACCGGGTTGCGCCCAGAGGTGGTGGAAAAACTTCAGTCG GACAAGACTGGCTTTCCTCAAAAGCAACATGTCTTCCATGCATCCGACGTTCCTAAATGGATGCAATGGGACCCG TTTATCCAACGAGGATACCGAACCCAGCTGAATAGTTTCAAGCGGTGTTTCTGGTCCCTATTCTATCTACATAAT GAATCAATCAACACCTGGTCACACGTCCTTGCAGGAATTTATTTCCTCGCCGTTCTTCTCGCCACCGACTATTGG ATCGCCCAACTGGGACTCAAAGTGCCATTATCAGACATACTTGCTATTCAGACGTATGTTGCCGGCACTGCAGGG TGTCTCATATTCTCCGTCAGTCTCTCCGTTAATCAATCCTTTTTACAAAATCCAGAAGTACTTAACTGATCCTCA CAATTCTAGGCTACCTTCCACGCAACCAACGCTCATTCGCCTGAAGTCGCTCATGCCTTCCTCAAACTAGATTAC TTCGGAATTGTGCTCACCATCTCAACTACATGTATCTCAGTCGCTTATTTCGCCCTGCACGGAGAACCGAGGCTC CAATGCGTCTACATTTTCTTCACTGTTCTCTGCGCAGCTATGGTCTTCTGTATCACACTTGATGTCGGTATGGAT GGTACACGTGCTGGTCCATGGAGGTAAGCTCTAGCATAATATCTTCTCATGTGTTATTGCAGCATTTCAGTTCAA TAACACCTGTTCTTTCCTCACACAGAGCAACTGTATTCACCCTTCTTGCGGCTAGCGGCCTAGCCCCTATCTTCC ACGTCATCTCGAGCGGTTCCCCTCGCGATTTCATCCGCATCCCTTGGGAGACTCTCATAGTAACCTGTTCTTCAT ACGCAATTGGCACAGTGGCGTATCTCTTCCGGTTTCCAGAGCGGTATTGGCCGGCGCAATTTGATATTATCGTGA GTCTGATTCATGTTCATAACGGAAAGAGGATGGTTTGGGACTAATGAGAAATATAGGGTGCTAGCCATCAGATAT TCCATATTTTGGTTGCGTTTGGCCAGGTTGTGCATCTGTTCGGACTTCGGGATGTGCTTGTAGGAATCCACCTAG AGTCGCATACGGTGTAGGCACTCAGTAGTACCGTACCATACGTCTCAATGAAGAGAAAGTGTGTTTTAAAATGAG GTGGCAGTGAAGAGCTTTGGTAGAATGCAATAATTCAGGAAAACGAACGAGTTCTATAAGGCCAACCCGGATCAG AAAAGGATGCTGTTCATGTCACGGATAGTTAGCCAGATGGAAATCAAATGATTCGGGCATGGCAATTTCAACTAT CAGTCGGGCCTGTCAAACTTCATGCATTCCAGCTAACTAAATCAATCCATCGCACAAATGTCATCAATAGTGTCC ACGCTTTGGGCAAGATTCACGAGGTCAGGTGCCCAGATGAGCACCTGACCTGTATTCAACTTACGTAATTATCAG GTGATCTGGGTGTTTACCTGATTATGTAAGACTCAGGGCGTGCTCAATTTTACTCAGGGGAGCAAAAGCGGCAAG GAATAAGCACTAAAACGCAAAGGGAAAGGTGATGACCATGCAGCAATGCTTCCCCACTGTCCGAGATGAGGTTGA TCGTGGGGTGAGATCATGTCTTCTGATACTATCGGTTATAGAAGAAATATTGTATATCGCACATCTTTTCCTAGA GTAGTAAAATAGTGTATGGCATGTGATAGTGAAATCGTCATAAAAGGAACCAAGTGGCTCAAAGGGCCCGAAGAA AATGGCTACCATTGGCCCTCGTGACGTTTGTTAGGTCACCGCCAAACTTGACTTGAATCCGGGGAATCTCTACTT TTATAACTCGTTTACTGGTTTCGTTTTTATTATAATACTTTCATTCCGGAGCTAACAGATCTCCGCATTTCACAC CCCGGCTGAATGGCTTGCTTCTCTAATGCACAGGCCTACCATGTCGGTGTTGGGCGACCCCACATTAGTTCAGTG CCATCATGGGCGCAAACACTCCCAAGAATACTCTTTACCCCAACCCTTACCTCCGCGACCGCTCTGCAAAACGAT CTCCATCCCAACCGTATCGTCGCTCGTGAAGGATTCGTGGAATTGGGCCGGTGATACTCTGCACACCTACCGTGA TGGTCTCTCGAAGGAACAACGGAAACAAAGGGCGGACATCGAGGACCGCAAGCAAGTCCTGTATCTGAAAATAAA GAATGTATGTACATGCGGTGTACCTGGGCCGAGCGATCGCATCTGCAGGGTGACCCCTTTCTAACCCTTGGGCTG CAGGCTGTGTCGTACGAAGAATGGCGAAGTTGCGCCAGTGAACTGGACGAACTAGAGGATAACAACGCTTGGAAG CAGACACTCGAGTGCACCGAATATGATCCTCGTTTGGTACAGGATCGTTTGCGACAGTTGGAAGAGGCTCGCATC AGCTGTGATGTAAGCCGGATGTTGTTCTTGGTGCGTACTGCGCTGAGTCGGGACCTGGCGCATATGAGCAATGCC TCTCTCTATCGCCATTCGCATATTGGTACAAAGGACTTGATCGATAGGTATATCACCACGGCTTTGGATACTATC GCTACGCTGGTGGATCTCTCGGTGCATGATCGCTGTGATGGGTTGGAGCTGAAGTATATCCTGGACCAGCTCCTG GCAGCTCGACAGGCATTTGGTCGCAGTGCTCTCCTTTTCTCCGGTGGTGCCACTTTTGGCATGACCCATATCGGG GTTCTCAAGGCCCTCTATGAAGCAAAAATGATTCCGCGAATTATCTCAGGTGCCTCGGCTGGTAGCATTGTGTGC GCGGTATTTTGCACGCGCACAGACGAAGAGCTTCCGGCGCTTTTGGATACCTATGTACATGGGGATTTCGACGTT TTCAATGAAAAGGGCCAAGAGGAAAATATCTTGCAGAAGATGACTCGTTTTTTGAAGTTTGGATCATTTTTTGAC ATATCTCACTTGGCGAAGACTATCAGAAACTGGCTGGGGGATATGACTTTTCAGGAAGCATATAACCGCACCCGC AGAATCCTAAATATCTGTGTGTCAAGTGCCGGCATGTATGAGCTTCCACGGCTGTTGAACTATATTTCTGCTCCC AATGTGTTGATCTGGTCTGCTGTGTAAGTTCCTCCTTTTTCACATCATCAACCCATTTCTAACGTCTTTCAAGCG CGGTATCATGCTCTGTTCCTTTTGTCTTTAGGCCATTCACGTTGATGGCTAAAGATCCGTTGACAGGGGAACCGG TCCCCTGGAATGATCTTCACAAGCAGTATATTGATGGCTCGGTCGATGGAGATTTACCCATGACACGCTTATCGG AGATGTTTAACGTGAATCACTTTATAGTCTCCCAAGTGAACCCCCATGTGGTTCCATTTCTTCCAAAGGAAACAG GCCCACAGGATGCGACAAACGACGGCCCTTCGTTCATTCCTCGATGGATGAACATGATGGCGCACCTTGCCAAAG ACGAGGTTCTGCATCGGATGAACGTCCTCTCAGAACTTGGAGTCTTTCCAACATCAATGACCAAGTTTGCCTCTA TTGTGAACCAGAAATATCATGGAGACATCAACATATACCCAGAACTCCTTTCCTCTAACCTCCCAAGGCTCCTGG AGAATCCCACAACGGAGTTCATGCTTTCGTCATGCCTGAGTGGCGAGCGGGCGACATGGCCGAGACTAAGCCGTA TCCGAAACCACTGCGCCATTGAGCTGGCACTCGATAATGCAATTCAAAATATGCGGGCCCGGGTGGCCTTCAGTC CAAGTCAGGTTGATCTACGTATGCCGCACCGTAGTCGTCACTCGATTGACTCGGCAGACAGCAACGGAAGGGGAC GTTATCGGGACAGGCGAAGAGGGTCCCACAGCCCCGAATTTGAAAAGAGGCAGTCGGGTGGGCAGGAACTACGTC GGCCAGATCACGAACTGAGAAAGGAACGAAGCACTGTTTCGTTAGAGAACCCGCCTCTCTCGCAATCAAGCGAGT CAATCTTCATGCCAACCCAAACAAGGACCCACCGCCGTACATCCTCAGTATTCTTCAGCAATGGAGGGATGTTCG ATATTGGGTCAAGCAGCGATGACGAGCTCGAACGATCATACATGCTTCGTCCCAAACTCGCAGGCCACCGAACGT TCTCAGAGTCATCTTCGTTTGGCAGAGTAGCTCCGAGTCACGGGCCCCGCAGCCCTGTCCGGTCCCGACGATCAT CATTATCCTCTAACCCGGCCTATAATTTCTCCTCCACGGCTCGTCGCAGTTCCCCAAAGCAGGTTTATACGCCGT CGGCTCGCGATTTCTCCGTGACCATACCACCTTCATCCCGCCATCTGCTCAGTATGACTCCAACGCCAACACTCC TTCCGAGCTCGCCTGAGCCCCTCACGCGCAAGCGGCAGAATTGA