Fungal Genomics

Agaricus bisporus var bisporus H39 Agaricus bisporus var bisporus H97 Agaricus bisporus var burnettii H119p4 Aspergillus niger CBS 112.32 Aspergillus niger CBS 113.50 Aspergillus niger CBS 115988 Aspergillus niger CBS 115989 Aspergillus niger CBS 118.52 Aspergillus niger CBS 124.48 Aspergillus niger CBS 131.52 Aspergillus niger CBS 133816 Aspergillus niger CBS 147320 Aspergillus niger CBS 147321 Aspergillus niger CBS 147322 Aspergillus niger CBS 147323 Aspergillus niger CBS 147324 Aspergillus niger CBS 147343 Aspergillus niger CBS 147344 Aspergillus niger CBS 147345 Aspergillus niger CBS 147346 Aspergillus niger CBS 147347 Aspergillus niger CBS 147352 Aspergillus niger CBS 147353 Aspergillus niger CBS 147371 Aspergillus niger CBS 147482 Aspergillus niger CBS 630.78 Aspergillus niger CBS 769.97 Niveomyces coronatus CBS 149186 Ophiocordyceps australis 1348a (Ghana) Ophiocordyceps australis map64 (Brazil) Ophiocordyceps camponoti-floridani Ophiocordyceps camponoti-rufipedis Ophiocordyceps kimflemingae Ophiocordyceps subramaniannii Penicillium roqueforti DTO002I6 Penicillium roqueforti DTO003C3 Penicillium roqueforti DTO003H1 (CBS 147308) Penicillium roqueforti DTO006G1 Penicillium roqueforti DTO006G7 Penicillium roqueforti DTO012A1 Penicillium roqueforti DTO012A2 (CBS 147309) Penicillium roqueforti DTO012A6 (CBS 147310) Penicillium roqueforti DTO012A7 Penicillium roqueforti DTO012A8 Penicillium roqueforti DTO012A9 Penicillium roqueforti DTO013E5 Penicillium roqueforti DTO013F2 Penicillium roqueforti DTO013F5 (CBS 147311) Penicillium roqueforti DTO027I6 Penicillium roqueforti DTO032C6 Penicillium roqueforti DTO039G3 Penicillium roqueforti DTO046C5 Penicillium roqueforti DTO070G2 (CBS 147317) Penicillium roqueforti DTO081F9 (CBS 147318) Penicillium roqueforti DTO101D6 (CBS 147325) Penicillium roqueforti DTO102I9 (CBS 147326) Penicillium roqueforti DTO126G2 (CBS 147330) Penicillium roqueforti DTO127F7 (CBS 147331) Penicillium roqueforti DTO127F9 (CBS 147332) Penicillium roqueforti DTO130C1 (CBS 147333) Penicillium roqueforti DTO163C3 (CBS 147337) Penicillium roqueforti DTO163F5 (CBS 147338) Penicillium roqueforti DTO163G4 (CBS 147339) Penicillium roqueforti DTO265D5 (CBS 147372) Penicillium roqueforti DTO369A1 (CBS 147354) Penicillium roqueforti DTO375B1 (CBS 147355) Penicillium roqueforti DTO377G2 (LCP 96.3914a) Penicillium roqueforti LCP96 04111 Rhodonia placenta FPRL280 Torrubiellomyces zombiae CBS 149187

General Properties

Protein ID	Pro_DTO377G3_2|g6238.t1
Gene name
Location	scaffold_16:295970..299261
Strand	+
Gene length (bp)	3291
Transcript length (bp)	3141
Coding sequence length (bp)	3141
Protein length (aa)	1047

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PFAM Domains

PFAM Domain ID	Short name	Long name	E-value	Start	End
PF00009	GTP_EFTU	Elongation factor Tu GTP binding domain	2.7E-33	457	665
PF11987	IF-2	Translation-initiation factor 2	7.5E-22	781	893
PF03144	GTP_EFTU_D2	Elongation factor Tu domain 2	1.0E-09	694	769
PF01926	MMR_HSR1	50S ribosome-binding GTPase	1.2E-05	458	581

GO

GO Term	Description	Terminal node
GO:0005525	GTP binding	Yes
GO:0003924	GTPase activity	Yes
GO:0036094	small molecule binding	No
GO:0003824	catalytic activity	No
GO:0035639	purine ribonucleoside triphosphate binding	No
GO:0043167	ion binding	No
GO:0017076	purine nucleotide binding	No
GO:0097367	carbohydrate derivative binding	No
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	No
GO:0016462	pyrophosphatase activity	No
GO:0000166	nucleotide binding	No
GO:0005488	binding	No
GO:0017111	nucleoside-triphosphatase activity	No
GO:0003674	molecular_function	No
GO:0032561	guanyl ribonucleotide binding	No
GO:0019001	guanyl nucleotide binding	No
GO:0097159	organic cyclic compound binding	No
GO:0032553	ribonucleotide binding	No
GO:0032555	purine ribonucleotide binding	No
GO:0016787	hydrolase activity	No
GO:1901363	heterocyclic compound binding	No
GO:0043168	anion binding	No
GO:0016817	hydrolase activity, acting on acid anhydrides	No
GO:1901265	nucleoside phosphate binding	No

SignalP

[Help with interpreting these statistics]

SignalP signal predicted	Location (based on Ymax)	D score (significance: > 0.45)
No	1 - 45	0.45

Transmembrane Domains

(None)

Transcription Factor Class

(None)

Expression data

Analysis 1: Genome-wide gene expression in conidia of Penicillium roqueforti during growth at various temperatures and for various amounts of time. Published in Punt et al., 2020.

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Sequences

Type of sequence	Sequence
Locus	Download genbank file of locus The gene with 5 kb flanks (if sufficient flanking sequence is available). For use in cloning design programs. NOTE: features (genes or exons) that are only partially contained within the sequence are completely excluded.
Protein	>Pro_DTO377G3_2|g6238.t1 MAPKKKSNKRQEEDWEADLGESVPAAAPADEQPQEDANEEAAPVGGLMAALRKNKAKKAKKGKTNDFVEGEDAEG VDALASKQPEEGNFDDDDVFAGKKTKPIKEVVKPAAEEPEGEFRVKSKKEKEREKKEKEKQRKKEQAATKKKLTP AQEKAEAKKTAAAEAKKDEAAAAAAASTTETGKKKKLPPHLAALQKQQELLRKQREEEERIAAEEKAAAAKQKLL DEEEEKKRAEARERKKEKEREKKEQLRKEGKLLTKAQREAKERNELRMQQMIAAGAKVAGLEEGGEKKQRPVYEN KKKRAGKKQEEDLEAAAARAQAQREAEDRKKAAEEKAKAEAAAAAAAAAAVTPTEEDAIEDWEQAADEDVKDSWD AESDEEEKPAQEAPSQKDQKEESGSESESDSDESSDEDSSDEEQSANQRAIQARKAEAAERRKLKHEEALAARSK DDLRSPICCILGHVDTGKTKLLDKIRQTNVQEGEAGGITQQIGATYFPVDALRTKTQVVNKDGKFEFKVPGLLII DTPGHESFSNLRSRGSSLCNIAILVVDIMHGLEPQTLESMRLLRDRKTPFIVALNKIDRLYGWKKIDNNGFEDSL AMQNKGVQNEFRTRLEATKLAFAEQGFNSELFFENKSLSRNVSLVPTSAHTGEGVPDMLKLLTSLSQERMTNSLM YLSEVECTVLEVKVIEGLGTTIDVILSNGILREGDRIVMCGLNGPITTNIRALLTPAPLKELRLKSQYVHNKEVK AALGVKIAANDLEHAIAGSRMLVVGPDDDEEDLEEEVMTDLENLLSRVSTDQRGVTVQASTLGSLEALLEFLKVS KIPVANISIGPVYKRDVMMAGTMLEKNKEYAVMLCFDVKVDKDAMAYANEIGVKIFTADIIYHLFDNFTEHMAQI TEQRKEEAKLLAIFPCVIKPIAVFNKTDPIVIGVDVIEGSLRLHTPLAAVRTNAAGVREIIDIGRVTSIERDHKA VPVCKRGQPSVAVKVEGPNQPMYGRHLEEKDQLISHISRASIDTLKEFYRSEVSMEEWALVKRLKPVFDIP*
Coding	>Pro_DTO377G3_2|g6238.t1 ATGGCGCCCAAGAAGAAGAGTAACAAGAGGCAGGAAGAGGACTGGGAGGCTGATCTCGGCGAGTCCGTTCCCGCC GCCGCTCCCGCCGACGAGCAGCCCCAAGAAGATGCCAACGAGGAGGCAGCGCCGGTCGGTGGCCTTATGGCTGCT TTGAGAAAAAACAAAGCCAAGAAGGCTAAGAAGGGCAAGACCAATGACTTTGTCGAGGGTGAGGACGCCGAGGGT GTCGATGCTTTGGCTAGCAAGCAGCCCGAGGAGGGTAACTTCGATGATGACGATGTCTTCGCTGGAAAGAAGACC AAGCCCATCAAGGAAGTGGTTAAGCCTGCGGCGGAAGAGCCTGAGGGCGAGTTCCGAGTAAAGAGTAAGAAGGAG AAGGAGCGTGAGAAGAAGGAGAAGGAGAAGCAGCGCAAGAAGGAGCAGGCTGCCACAAAGAAGAAGCTCACCCCT GCTCAAGAAAAGGCCGAAGCCAAGAAGACTGCCGCCGCTGAAGCCAAGAAGGATGAAGCCGCCGCCGCCGCCGCC GCATCTACCACAGAGACTGGCAAGAAGAAGAAGCTCCCTCCTCACCTAGCAGCCCTTCAGAAACAACAGGAGCTT CTTCGGAAGCAACGTGAGGAGGAGGAGCGCATTGCAGCGGAGGAGAAGGCTGCCGCGGCCAAGCAGAAGCTCCTC GATGAAGAGGAAGAGAAGAAGCGTGCAGAGGCTCGTGAGCGCAAGAAGGAGAAGGAGCGCGAAAAGAAGGAACAG CTACGCAAGGAAGGCAAGCTGCTTACCAAAGCTCAACGAGAGGCCAAGGAGCGCAATGAATTGCGCATGCAGCAG ATGATTGCCGCTGGTGCCAAGGTTGCTGGCTTAGAGGAGGGTGGCGAAAAGAAGCAGCGCCCTGTATATGAGAAC AAGAAGAAGAGGGCTGGCAAGAAGCAGGAAGAGGACCTCGAAGCCGCCGCCGCTCGAGCCCAGGCTCAGCGCGAA GCTGAAGATCGAAAGAAGGCGGCCGAGGAGAAGGCGAAGGCTGAGGCCGCCGCCGCTGCCGCTGCTGCTGCTGCC GTCACTCCTACGGAAGAGGACGCCATTGAAGACTGGGAGCAGGCTGCCGATGAAGATGTCAAGGACAGCTGGGAT GCGGAATCTGATGAGGAAGAGAAGCCCGCTCAGGAGGCACCTTCCCAAAAGGATCAGAAAGAAGAATCCGGCTCC GAGTCCGAGTCCGACTCCGACGAATCATCTGATGAAGATTCATCTGACGAAGAGCAATCCGCCAACCAAAGGGCC ATTCAGGCAAGAAAGGCCGAGGCTGCGGAGCGAAGAAAGCTCAAGCACGAGGAGGCTCTGGCGGCTCGTTCGAAG GATGATCTTCGATCCCCTATTTGCTGTATTCTTGGTCACGTCGATACTGGTAAGACCAAGCTGCTTGACAAAATC CGACAGACCAACGTGCAGGAGGGCGAAGCTGGTGGTATTACCCAGCAAATCGGTGCCACTTACTTCCCCGTCGAT GCTCTACGCACAAAGACCCAGGTTGTCAACAAGGATGGCAAGTTCGAGTTCAAGGTCCCTGGTCTGTTGATCATC GATACCCCCGGTCACGAGTCCTTCTCCAACTTGCGATCAAGAGGTTCCTCCCTCTGCAACATTGCTATTCTTGTT GTTGATATCATGCACGGTCTCGAGCCCCAGACTCTTGAGTCTATGCGTTTGCTGCGTGACCGCAAGACTCCTTTC ATCGTCGCATTGAACAAAATCGATCGTCTTTATGGCTGGAAGAAGATTGATAACAATGGCTTCGAAGATAGTTTG GCTATGCAGAACAAGGGTGTTCAAAACGAGTTCCGCACTCGTCTTGAGGCCACCAAGCTTGCTTTCGCCGAGCAG GGTTTCAACTCCGAGCTGTTCTTCGAGAACAAGTCTCTGTCTCGCAACGTATCTCTCGTTCCGACCTCCGCCCAC ACCGGAGAGGGTGTTCCTGACATGCTGAAGCTGCTGACCAGCTTGAGTCAAGAGCGTATGACTAACTCGCTTATG TACTTGTCTGAGGTCGAGTGTACGGTTCTGGAAGTCAAGGTCATTGAGGGTCTCGGTACCACCATTGACGTTATT CTATCCAACGGTATTCTTCGCGAGGGTGATCGCATCGTAATGTGCGGTCTCAACGGACCTATTACAACCAATATT CGTGCTCTTCTGACACCAGCACCGCTCAAGGAGCTGCGTCTGAAGTCCCAGTACGTTCACAACAAGGAGGTCAAG GCCGCCCTTGGTGTGAAGATTGCTGCCAACGACTTGGAGCACGCTATCGCCGGTTCTCGCATGCTTGTCGTCGGC CCTGATGATGATGAGGAGGATCTTGAGGAGGAGGTCATGACCGATCTGGAGAATCTGCTGAGTCGTGTCTCGACT GATCAGCGTGGTGTCACTGTCCAGGCCTCTACCCTAGGCTCCCTTGAGGCTCTCCTGGAGTTCCTCAAGGTTTCT AAGATTCCTGTTGCCAATATCTCCATCGGTCCCGTTTACAAGCGTGATGTCATGATGGCTGGTACCATGCTCGAG AAGAATAAGGAATATGCTGTCATGCTGTGCTTCGATGTCAAGGTCGATAAGGATGCGATGGCCTATGCCAACGAA ATCGGTGTAAAGATCTTCACCGCCGACATCATTTACCACTTGTTCGATAACTTCACTGAGCACATGGCTCAAATC ACAGAGCAGCGTAAGGAGGAGGCTAAGCTTCTTGCTATCTTCCCCTGTGTCATCAAGCCCATTGCTGTCTTCAAC AAGACCGACCCTATCGTCATCGGTGTTGATGTCATTGAAGGAAGCCTGCGTCTCCACACTCCTTTGGCTGCGGTC AGGACCAATGCCGCTGGTGTAAGGGAGATTATTGATATTGGTAGAGTCACATCCATCGAGCGCGATCACAAGGCT GTTCCAGTTTGCAAGAGAGGCCAGCCCTCCGTTGCTGTTAAGGTCGAGGGTCCGAACCAGCCCATGTATGGTCGT CACCTCGAAGAGAAGGATCAGCTTATCTCGCATATCTCGCGTGCTAGTATCGATACCCTCAAGGAGTTCTACCGG TCCGAGGTATCCATGGAGGAATGGGCTCTGGTCAAGAGGCTCAAGCCCGTCTTCGACATTCCTTGA
Transcript	>Pro_DTO377G3_2|g6238.t1 ATGGCGCCCAAGAAGAAGAGTAACAAGAGGCAGGAAGAGGACTGGGAGGCTGATCTCGGCGAGTCCGTTCCCGCC GCCGCTCCCGCCGACGAGCAGCCCCAAGAAGATGCCAACGAGGAGGCAGCGCCGGTCGGTGGCCTTATGGCTGCT TTGAGAAAAAACAAAGCCAAGAAGGCTAAGAAGGGCAAGACCAATGACTTTGTCGAGGGTGAGGACGCCGAGGGT GTCGATGCTTTGGCTAGCAAGCAGCCCGAGGAGGGTAACTTCGATGATGACGATGTCTTCGCTGGAAAGAAGACC AAGCCCATCAAGGAAGTGGTTAAGCCTGCGGCGGAAGAGCCTGAGGGCGAGTTCCGAGTAAAGAGTAAGAAGGAG AAGGAGCGTGAGAAGAAGGAGAAGGAGAAGCAGCGCAAGAAGGAGCAGGCTGCCACAAAGAAGAAGCTCACCCCT GCTCAAGAAAAGGCCGAAGCCAAGAAGACTGCCGCCGCTGAAGCCAAGAAGGATGAAGCCGCCGCCGCCGCCGCC GCATCTACCACAGAGACTGGCAAGAAGAAGAAGCTCCCTCCTCACCTAGCAGCCCTTCAGAAACAACAGGAGCTT CTTCGGAAGCAACGTGAGGAGGAGGAGCGCATTGCAGCGGAGGAGAAGGCTGCCGCGGCCAAGCAGAAGCTCCTC GATGAAGAGGAAGAGAAGAAGCGTGCAGAGGCTCGTGAGCGCAAGAAGGAGAAGGAGCGCGAAAAGAAGGAACAG CTACGCAAGGAAGGCAAGCTGCTTACCAAAGCTCAACGAGAGGCCAAGGAGCGCAATGAATTGCGCATGCAGCAG ATGATTGCCGCTGGTGCCAAGGTTGCTGGCTTAGAGGAGGGTGGCGAAAAGAAGCAGCGCCCTGTATATGAGAAC AAGAAGAAGAGGGCTGGCAAGAAGCAGGAAGAGGACCTCGAAGCCGCCGCCGCTCGAGCCCAGGCTCAGCGCGAA GCTGAAGATCGAAAGAAGGCGGCCGAGGAGAAGGCGAAGGCTGAGGCCGCCGCCGCTGCCGCTGCTGCTGCTGCC GTCACTCCTACGGAAGAGGACGCCATTGAAGACTGGGAGCAGGCTGCCGATGAAGATGTCAAGGACAGCTGGGAT GCGGAATCTGATGAGGAAGAGAAGCCCGCTCAGGAGGCACCTTCCCAAAAGGATCAGAAAGAAGAATCCGGCTCC GAGTCCGAGTCCGACTCCGACGAATCATCTGATGAAGATTCATCTGACGAAGAGCAATCCGCCAACCAAAGGGCC ATTCAGGCAAGAAAGGCCGAGGCTGCGGAGCGAAGAAAGCTCAAGCACGAGGAGGCTCTGGCGGCTCGTTCGAAG GATGATCTTCGATCCCCTATTTGCTGTATTCTTGGTCACGTCGATACTGGTAAGACCAAGCTGCTTGACAAAATC CGACAGACCAACGTGCAGGAGGGCGAAGCTGGTGGTATTACCCAGCAAATCGGTGCCACTTACTTCCCCGTCGAT GCTCTACGCACAAAGACCCAGGTTGTCAACAAGGATGGCAAGTTCGAGTTCAAGGTCCCTGGTCTGTTGATCATC GATACCCCCGGTCACGAGTCCTTCTCCAACTTGCGATCAAGAGGTTCCTCCCTCTGCAACATTGCTATTCTTGTT GTTGATATCATGCACGGTCTCGAGCCCCAGACTCTTGAGTCTATGCGTTTGCTGCGTGACCGCAAGACTCCTTTC ATCGTCGCATTGAACAAAATCGATCGTCTTTATGGCTGGAAGAAGATTGATAACAATGGCTTCGAAGATAGTTTG GCTATGCAGAACAAGGGTGTTCAAAACGAGTTCCGCACTCGTCTTGAGGCCACCAAGCTTGCTTTCGCCGAGCAG GGTTTCAACTCCGAGCTGTTCTTCGAGAACAAGTCTCTGTCTCGCAACGTATCTCTCGTTCCGACCTCCGCCCAC ACCGGAGAGGGTGTTCCTGACATGCTGAAGCTGCTGACCAGCTTGAGTCAAGAGCGTATGACTAACTCGCTTATG TACTTGTCTGAGGTCGAGTGTACGGTTCTGGAAGTCAAGGTCATTGAGGGTCTCGGTACCACCATTGACGTTATT CTATCCAACGGTATTCTTCGCGAGGGTGATCGCATCGTAATGTGCGGTCTCAACGGACCTATTACAACCAATATT CGTGCTCTTCTGACACCAGCACCGCTCAAGGAGCTGCGTCTGAAGTCCCAGTACGTTCACAACAAGGAGGTCAAG GCCGCCCTTGGTGTGAAGATTGCTGCCAACGACTTGGAGCACGCTATCGCCGGTTCTCGCATGCTTGTCGTCGGC CCTGATGATGATGAGGAGGATCTTGAGGAGGAGGTCATGACCGATCTGGAGAATCTGCTGAGTCGTGTCTCGACT GATCAGCGTGGTGTCACTGTCCAGGCCTCTACCCTAGGCTCCCTTGAGGCTCTCCTGGAGTTCCTCAAGGTTTCT AAGATTCCTGTTGCCAATATCTCCATCGGTCCCGTTTACAAGCGTGATGTCATGATGGCTGGTACCATGCTCGAG AAGAATAAGGAATATGCTGTCATGCTGTGCTTCGATGTCAAGGTCGATAAGGATGCGATGGCCTATGCCAACGAA ATCGGTGTAAAGATCTTCACCGCCGACATCATTTACCACTTGTTCGATAACTTCACTGAGCACATGGCTCAAATC ACAGAGCAGCGTAAGGAGGAGGCTAAGCTTCTTGCTATCTTCCCCTGTGTCATCAAGCCCATTGCTGTCTTCAAC AAGACCGACCCTATCGTCATCGGTGTTGATGTCATTGAAGGAAGCCTGCGTCTCCACACTCCTTTGGCTGCGGTC AGGACCAATGCCGCTGGTGTAAGGGAGATTATTGATATTGGTAGAGTCACATCCATCGAGCGCGATCACAAGGCT GTTCCAGTTTGCAAGAGAGGCCAGCCCTCCGTTGCTGTTAAGGTCGAGGGTCCGAACCAGCCCATGTATGGTCGT CACCTCGAAGAGAAGGATCAGCTTATCTCGCATATCTCGCGTGCTAGTATCGATACCCTCAAGGAGTTCTACCGG TCCGAGGTATCCATGGAGGAATGGGCTCTGGTCAAGAGGCTCAAGCCCGTCTTCGACATTCCTTGA
Gene	>Pro_DTO377G3_2|g6238.t1 ATGGCGCCCAAGAAGAAGAGTAACAAGAGGCAGGAAGAGGACTGGGAGGCTGATCTCGGCGAGTCCGTTCCCGCC GCCGCTCCCGCCGACGAGCAGCCCCAAGAAGATGCCAACGAGGAGGCAGCGCCGGTCGGTGGCCTTATGGCTGCT TTGAGAAAAAACAAAGCCAAGAAGGCTAAGAAGGGCAAGACCAATGACTTTGTCGAGGGTGAGGACGCCGAGGGT GTCGATGCTTTGGCTAGCAAGCAGCCCGAGGAGGGTAACTTCGATGATGACGATGTCTTCGCTGGAAAGAAGACC AAGCCCATCAAGGAAGTGGTTAAGCCTGCGGCGGAAGAGCCTGAGGGCGAGTTCCGAGTAAAGAGTAAGAAGGAG AAGGAGCGTGAGAAGAAGGAGAAGGAGAAGCAGCGCAAGAAGGAGCAGGTAGGTTTTTACATTTTTCGCCATGCT GGAAATACGTGCCGGGTGTCCAGCTCATTTACTAATCGGTCTTTCTCTCGTCTACATAGGCTGCCACAAAGAAGA AGCTCACCCCTGCTCAAGAAAAGGCCGAAGCCAAGAAGACTGCCGCCGCTGAAGCCAAGAAGGATGAAGCCGCCG CCGCCGCCGCCGCATCTACCACAGAGACTGGCAAGAAGAAGAAGCTCCCTCCTCACCTAGCAGCCCTTCAGAAAC AACAGGAGCTTCTTCGGAAGCAACGTGAGGAGGAGGAGCGCATTGCAGCGGAGGAGAAGGCTGCCGCGGCCAAGC AGAAGCTCCTCGATGAAGAGGAAGAGAAGAAGCGTGCAGAGGCTCGTGAGCGCAAGAAGGAGAAGGAGCGCGAAA AGAAGGAACAGCTACGCAAGGAAGGCAAGCTGCTTACCAAAGCTCAACGAGAGGCCAAGGAGCGCAATGAATTGC GCATGCAGCAGATGATTGCCGCTGGTGCCAAGGTTGCTGGCTTAGAGGAGGGTGGCGAAAAGAAGCAGCGCCCTG TATATGAGAACAAGAAGAAGAGGGCTGGCAAGAAGCAGGAAGAGGACCTCGAAGCCGCCGCCGCTCGAGCCCAGG CTCAGCGCGAAGCTGAAGATCGAAAGAAGGCGGCCGAGGAGAAGGCGAAGGCTGAGGCCGCCGCCGCTGCCGCTG CTGCTGCTGCCGTCACTCCTACGGAAGAGGACGCCATTGAAGACTGGGAGCAGGCTGCCGATGAAGATGTCAAGG ACAGCTGGGATGCGGAATCTGATGAGGAAGAGAAGCCCGCTCAGGAGGCACCTTCCCAAAAGGATCAGAAAGAAG AATCCGGCTCCGAGTCCGAGTCCGACTCCGACGAATCATCTGATGAAGATTCATCTGACGAAGAGCAATCCGCCA ACCAAAGGGCCATTCAGGCAAGAAAGGCCGAGGCTGCGGAGCGAAGAAAGCTCAAGCACGAGGAGGCTCTGGCGG CTCGTTCGAAGGATGATCTTCGATCCCCTATTTGCTGTATTCTTGGTCACGTCGATACTGGTAAGACCAAGCTGC TTGACAAAATCCGACAGACCAACGTGCAGGAGGGCGAAGCTGGTGGTATTACCCAGCAAATCGGTGCCACTTACT TCCCCGTCGATGCTCTACGCACAAAGACCCAGGTTGTCAACAAGGATGGCAAGTTCGAGTTCAAGGTCCCTGGTC TGTTGATCATCGATACCCCCGGTCACGAGTCCTTCTCCAACTTGCGATCAAGAGGTTCCTCCCTCTGCAACATTG CTATTCTTGTTGTTGATATCATGCACGGTCTCGAGCCCCAGACTCTTGAGTCTATGCGTTTGCTGCGTGACCGCA AGACTCCTTTCATCGTCGCATTGAACAAAATCGATCGTCTTTATGGCTGGAAGAAGATTGATAACAATGGCTTCG AAGATAGTTTGGCTATGCAGAACAAGGGTGTTCAAAACGAGTTCCGCACTCGTCTTGAGGCCACCAAGCTTGCTT TCGCCGAGCAGGGTTTCAACTCCGAGCTGTTCTTCGAGAACAAGTCTCTGTCTCGCAACGTATCTCTCGTTCCGA CCTCCGCCCACACCGGAGAGGGTGTTCCTGACATGCTGAAGCTGCTGACCAGCTTGAGTCAAGAGCGTATGACTA ACTCGCTTATGTACTTGTCTGAGGTCGAGTGTACGGTTCTGGAAGTCAAGGTCATTGAGGGTCTCGGTACCACCA TTGACGTTATTCTATCCAACGGTATTCTTCGCGAGGGTGATCGCATCGTAATGTGCGGTCTCAACGGACCTATTA CAACCAATATTCGTGCTCTTCTGACACCAGCACCGCTCAAGGAGCTGCGTCTGAAGTCCCAGTACGTTCACAACA AGGAGGTCAAGGCCGCCCTTGGTGTGAAGATTGCTGCCAACGACTTGGAGCACGCTATCGCCGGTTCTCGCATGC TTGTCGTCGGCCCTGATGATGATGAGGAGGATCTTGAGGAGGAGGTCATGACCGATCTGGAGAATCTGCTGAGTC GTGTCTCGACTGATCAGCGTGGTGTCACTGTCCAGGCCTCTACCCTAGGCTCCCTTGAGGCTCTCCTGGAGTTCC TCAAGGTTTCTAAGATTCCTGTTGCCAATATCTCCATCGGTCCCGTTTACAAGCGTGATGTCATGATGGCTGGTA CCATGCTCGAGAAGAATAAGGAATATGCTGTCATGCTGTGCTTCGATGTCAAGGTCGATAAGGATGCGATGGCCT ATGCCAACGAAATCGGTGTAAAGATCTTCACCGCCGACATCATTTACCACTTGTTCGATAACTTCACTGAGCACA TGGCTCAAATCACAGAGCAGCGTAAGGAGGAGGCTAAGCTTCTTGCTATCTTCCCCTGTGTCATCAAGCCCATTG CTGTCTTCAACAAGACCGACCCTATCGTCATCGGTGTTGATGTCATTGAAGGAAGCCTGCGTCTCCACACTCCTT TGGCTGCGGTCAGGACCAATGCCGCTGGTGTAAGGGAGATTATTGATATTGGTAGAGTGTAAGTTTTGGTTCCCT GGATTTTTTCCCCCTTTTGTCTGATTTCTGACGCAATCGTTTCACAGCACATCCATCGAGCGCGATCACAAGGCT GTTCCAGTTTGCAAGAGAGGCCAGCCCTCCGTTGCTGTTAAGGTCGAGGGTCCGAACCAGCCCATGTATGGTCGT CACCTCGAAGAGAAGGATCAGCTTATCTCGCATATCTCGCGTGCTAGTATCGATACCCTCAAGGAGTTCTACCGG TCCGAGGTATCCATGGAGGAATGGGCTCTGGTCAAGAGGCTCAAGCCCGTCTTCGACATTCCTTGA