Fungal Genomics

Agaricus bisporus var bisporus H39 Agaricus bisporus var bisporus H97 Agaricus bisporus var burnettii H119p4 Aspergillus niger CBS 112.32 Aspergillus niger CBS 113.50 Aspergillus niger CBS 115988 Aspergillus niger CBS 115989 Aspergillus niger CBS 118.52 Aspergillus niger CBS 124.48 Aspergillus niger CBS 131.52 Aspergillus niger CBS 133816 Aspergillus niger CBS 147320 Aspergillus niger CBS 147321 Aspergillus niger CBS 147322 Aspergillus niger CBS 147323 Aspergillus niger CBS 147324 Aspergillus niger CBS 147343 Aspergillus niger CBS 147344 Aspergillus niger CBS 147345 Aspergillus niger CBS 147346 Aspergillus niger CBS 147347 Aspergillus niger CBS 147352 Aspergillus niger CBS 147353 Aspergillus niger CBS 147371 Aspergillus niger CBS 147482 Aspergillus niger CBS 630.78 Aspergillus niger CBS 769.97 Ophiocordyceps australis 1348a (Ghana) Ophiocordyceps australis map64 (Brazil) Ophiocordyceps camponoti-floridani Ophiocordyceps camponoti-rufipedis Ophiocordyceps kimflemingae Ophiocordyceps subramaniannii Penicillium roqueforti DTO002I6 Penicillium roqueforti DTO003C3 Penicillium roqueforti DTO003H1 (CBS 147308) Penicillium roqueforti DTO006G1 Penicillium roqueforti DTO006G7 Penicillium roqueforti DTO012A1 Penicillium roqueforti DTO012A2 (CBS 147309) Penicillium roqueforti DTO012A6 (CBS 147310) Penicillium roqueforti DTO012A7 Penicillium roqueforti DTO012A8 Penicillium roqueforti DTO012A9 Penicillium roqueforti DTO013E5 Penicillium roqueforti DTO013F2 Penicillium roqueforti DTO013F5 (CBS 147311) Penicillium roqueforti DTO027I6 Penicillium roqueforti DTO032C6 Penicillium roqueforti DTO039G3 Penicillium roqueforti DTO046C5 Penicillium roqueforti DTO070G2 (CBS 147317) Penicillium roqueforti DTO081F9 (CBS 147318) Penicillium roqueforti DTO101D6 (CBS 147325) Penicillium roqueforti DTO102I9 (CBS 147326) Penicillium roqueforti DTO126G2 (CBS 147330) Penicillium roqueforti DTO127F7 (CBS 147331) Penicillium roqueforti DTO127F9 (CBS 147332) Penicillium roqueforti DTO130C1 (CBS 147333) Penicillium roqueforti DTO163C3 (CBS 147337) Penicillium roqueforti DTO163F5 (CBS 147338) Penicillium roqueforti DTO163G4 (CBS 147339) Penicillium roqueforti DTO265D5 (CBS 147372) Penicillium roqueforti DTO369A1 (CBS 147354) Penicillium roqueforti DTO375B1 (CBS 147355) Penicillium roqueforti DTO377G2 (LCP 96.3914a) Penicillium roqueforti LCP96 04111 Rhodonia placenta FPRL280

General Properties

Protein ID	Pro_DTO377G3_2|g6169.t1
Gene name
Location	scaffold_16:131418..135103
Strand	+
Gene length (bp)	3685
Transcript length (bp)	3573
Coding sequence length (bp)	3573
Protein length (aa)	1191

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PFAM Domains

PFAM Domain ID	Short name	Long name	E-value	Start	End
PF00632	HECT	HECT-domain (ubiquitin-transferase)	6.7E-71	873	1189

GO

GO Term	Description	Terminal node
GO:0004842	ubiquitin-protein transferase activity	Yes
GO:0019787	ubiquitin-like protein transferase activity	No
GO:0140096	catalytic activity, acting on a protein	No
GO:0003824	catalytic activity	No
GO:0003674	molecular_function	No
GO:0016740	transferase activity	No

SignalP

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SignalP signal predicted	Location (based on Ymax)	D score (significance: > 0.45)
No	1 - 13	0.45

Transmembrane Domains

(None)

Transcription Factor Class

(None)

Expression data

Analysis 1: Genome-wide gene expression in conidia of Penicillium roqueforti during growth at various temperatures and for various amounts of time. Published in Punt et al., 2020.

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Sequences

Type of sequence	Sequence
Locus	Download genbank file of locus The gene with 5 kb flanks (if sufficient flanking sequence is available). For use in cloning design programs. NOTE: features (genes or exons) that are only partially contained within the sequence are completely excluded.
Protein	>Pro_DTO377G3_2|g6169.t1 MPSRPERHLPIPPISSAGNAAIPGIHPSQFSGLEINPRRMARPRDASIMPPLNGGTPKSSYHRGHSRSISNPFAG FGRKRDKTVAKYATWDSDDDDDDEVTYPLEPESSSPRKGAAPGNDLAEGKCQTCDATVRWPRHLKVFRCTDCLMI TDLEPISHDSKDKPPQGSQGGASNLASKVFPLTANQIRGMVGGCLNMYFDSLLDNSPRSWLSPDDDRKNKPLPNL PPMQDHASGPKNLSPPRTGDSRSRSASHSSERERLAASKENSGYLTPPSVRWEGNDTPVRVRANSDLRSTPKLDS RTQDVSQAGNPEFQSCDNRTHIFKRLENTIATAFKGCDCLNESFTTYPPPRSARAASNGNPPKTKMEPTTMPQPA QDAPVFEPDAKTLLLGDLTENSSWWMNEWAETEGQNPAYSKEKNTPKSRMISSRSPRINWSELAQWYHSILSAGN SWNELWAAKKPDPTRSEADLIRAKRWASIDPSLIGRQVSESRLHLQRALLKATEGLLKRPRRVLKKPEDTRFLFI LLANPMLSSPASYYQNTSISPSHRDERRPSHPKDYLKSATRDGKPLQKEPHKAPARLDGSSHHYGIIKRILGLAS NLPNDCHHYIVSWASRFSVRHFERLVELIGGFLTYRLSRQHGRKRPQNPQNGDDLIPSFASASGNTAAELHAAIN RSSPNKKPGKKTEDPIIYAEDWQIRAAARVMSLFFTANISSATRKSDGTPRSLEVPKNPGPRQGHMIPISAFYNT LLDYSDLVADFETWEAKVSKFSFCQYPFLLSIWAKIHIMEHDARRQMEVKARDAFFDSVLNHTAVSQYLVLKVRR ECLIEDSLKGVSEIVGTGQEEIKKGLRIEFSGEEGIDAGGLRKEWFLLLVREVFDPLHGLFIYDDDSQYCYFNPY CFESSEQFFLVGVLLGLAIYNSTILDVSLPPFAFKKLLSSAGHANGPQLATSLRSTFKCTLEDLAEYRPALAKGL RGLLEFEGNVAETFCYDFVAQVDRYGEIISVPLCANGENRPVTNSNKREFVDLYVQYLLDTAVARQFEPFKRGFF TVCGGNALSLFRPEEIEMLVRGSDEPLDVNSLRAVATYDNWSHPRPESVPVVRWFWDFLEKSDPQAQRKILSFIT GSDRIPAMGATSLIIRLACLGDDCPRYPIARTCFNTLGLYRYPTRGKFQRLLWDAVVNSEGFGLK*
Coding	>Pro_DTO377G3_2|g6169.t1 ATGCCGTCCCGGCCTGAACGTCATCTGCCTATCCCTCCGATCTCAAGTGCTGGCAACGCCGCCATCCCTGGAATA CACCCTTCCCAATTTTCTGGACTGGAAATCAATCCACGCCGTATGGCTCGACCTCGCGATGCTTCGATCATGCCC CCATTAAACGGCGGTACCCCCAAGAGTTCGTACCACCGAGGACATTCACGCTCGATCAGCAATCCGTTCGCTGGG TTTGGGCGAAAACGGGACAAGACAGTCGCCAAGTATGCGACTTGGGACTCTGACGATGATGACGACGATGAGGTA ACATATCCCTTGGAGCCAGAGTCGTCAAGTCCCCGGAAAGGTGCAGCACCTGGAAATGATCTCGCCGAGGGCAAG TGTCAGACTTGTGATGCTACCGTCCGGTGGCCACGGCACTTGAAGGTGTTTAGATGTACCGACTGCTTGATGATC ACAGACCTCGAGCCGATTTCTCATGATTCAAAAGACAAACCCCCACAAGGGTCTCAGGGTGGAGCGTCCAATTTG GCAAGCAAAGTGTTTCCTTTGACGGCCAATCAAATTCGTGGTATGGTCGGGGGGTGTCTCAACATGTATTTCGAT AGCCTTTTGGACAATAGCCCTCGGTCATGGTTGTCGCCGGACGACGACAGAAAGAACAAACCGCTACCTAATCTT CCGCCAATGCAGGATCATGCCTCTGGTCCAAAAAATCTCTCGCCCCCACGCACTGGCGATTCTCGGAGTCGTAGT GCTTCCCATTCTAGTGAACGGGAAAGGTTGGCGGCGTCAAAAGAAAACTCAGGTTACTTGACACCACCATCTGTT CGCTGGGAGGGCAATGACACGCCTGTCAGAGTCCGAGCAAATTCAGATCTCCGATCAACTCCAAAGCTAGACAGC CGCACGCAAGACGTTTCGCAAGCCGGGAACCCGGAGTTTCAAAGCTGCGACAATCGGACACACATTTTCAAACGG CTGGAAAATACCATCGCCACTGCCTTCAAAGGCTGTGACTGCCTCAACGAATCTTTCACTACATATCCACCACCT CGGTCAGCCCGAGCAGCTAGTAATGGTAATCCACCGAAAACGAAGATGGAACCGACCACAATGCCCCAACCAGCG CAAGACGCTCCAGTTTTTGAACCAGATGCCAAAACTCTTCTTTTAGGAGATTTGACTGAGAACTCCTCTTGGTGG ATGAATGAATGGGCTGAGACCGAAGGCCAAAATCCCGCATATTCCAAAGAGAAGAACACCCCAAAGTCTCGGATG ATATCATCGCGAAGTCCTCGGATCAACTGGTCCGAGTTAGCCCAGTGGTACCATTCGATCCTGTCCGCGGGAAAT TCTTGGAATGAGCTCTGGGCCGCCAAAAAGCCTGACCCCACAAGATCAGAAGCGGATCTGATCCGAGCCAAGAGA TGGGCGTCTATTGATCCGTCCTTGATCGGAAGACAAGTCAGCGAGTCTCGTTTGCACTTACAACGGGCACTCTTG AAAGCTACCGAGGGCCTCCTCAAACGCCCGCGCCGTGTTCTGAAGAAACCAGAAGATACCAGGTTCTTGTTCATA TTGTTAGCGAATCCCATGTTGTCTTCACCTGCGTCTTATTATCAGAATACATCCATCTCGCCGTCTCATCGAGAT GAGAGGCGCCCATCGCATCCAAAAGACTACCTGAAATCGGCAACCCGAGACGGAAAACCCTTGCAGAAAGAGCCG CACAAAGCCCCTGCTCGTCTAGATGGCTCCAGTCACCATTATGGAATTATCAAACGAATCCTGGGACTCGCGTCT AATTTGCCCAATGACTGCCATCACTACATCGTGTCTTGGGCTTCCCGTTTCTCTGTTAGACATTTCGAGCGACTG GTAGAACTTATCGGTGGATTTCTCACTTACCGTTTGAGTCGCCAGCATGGGCGAAAACGCCCTCAAAATCCTCAA AACGGAGATGATCTAATACCGAGCTTTGCCAGTGCTTCGGGAAATACTGCTGCGGAACTCCACGCTGCGATTAAT CGAAGTAGCCCGAACAAGAAGCCTGGCAAAAAGACCGAAGACCCCATAATATACGCCGAGGACTGGCAGATCAGA GCAGCAGCAAGAGTAATGTCGCTGTTCTTCACGGCTAACATCTCCTCTGCAACGAGGAAGTCTGATGGAACTCCG CGCAGTCTTGAAGTTCCCAAGAACCCAGGCCCTCGTCAAGGACATATGATTCCAATCAGTGCATTCTACAATACA CTGCTGGACTATTCGGATTTAGTGGCGGACTTCGAGACTTGGGAGGCTAAAGTCTCGAAGTTTTCGTTCTGTCAG TATCCGTTCCTCCTTAGCATCTGGGCCAAAATTCATATCATGGAGCATGATGCGCGTCGTCAAATGGAAGTGAAA GCACGCGATGCATTTTTCGACAGCGTCCTCAACCACACGGCGGTTAGTCAGTACCTGGTGTTGAAGGTACGGCGT GAGTGTTTGATTGAAGACAGCCTGAAGGGAGTGAGTGAAATTGTTGGTACTGGCCAAGAAGAAATCAAAAAGGGT CTCCGGATCGAATTTTCGGGCGAAGAAGGCATTGATGCTGGCGGCCTGCGGAAGGAATGGTTTCTGCTGCTTGTT CGAGAGGTCTTTGACCCGCTTCATGGCCTCTTCATCTACGATGACGATTCGCAGTATTGCTACTTCAATCCTTAT TGCTTTGAGTCATCCGAACAATTCTTCTTGGTTGGGGTTCTTCTAGGTCTCGCCATCTACAACTCCACCATCCTT GATGTTAGTCTCCCGCCGTTTGCGTTTAAGAAATTGCTGTCGTCAGCGGGGCATGCCAACGGGCCACAACTGGCT ACTTCCTTGCGTTCGACCTTCAAATGCACCCTAGAAGATCTTGCCGAGTACCGGCCAGCTCTCGCCAAAGGACTC CGGGGTCTGCTAGAATTCGAAGGCAATGTCGCGGAGACATTCTGCTACGATTTCGTTGCCCAGGTCGATCGCTAC GGCGAGATTATCAGTGTGCCACTCTGTGCAAATGGCGAGAACCGACCGGTGACCAACTCCAACAAGCGTGAGTTT GTGGATTTGTATGTCCAATATCTGCTAGACACAGCCGTGGCTCGACAGTTCGAACCTTTCAAACGCGGTTTCTTC ACGGTCTGCGGCGGCAATGCACTATCACTATTCCGACCAGAAGAGATCGAAATGCTAGTCCGCGGCTCAGATGAA CCACTCGATGTCAATTCTCTCCGGGCGGTGGCCACCTACGACAACTGGTCACACCCACGACCAGAATCAGTCCCT GTAGTGCGCTGGTTCTGGGACTTCTTGGAGAAATCAGACCCTCAAGCACAGCGCAAGATCTTGTCATTCATTACT GGTAGCGATCGGATCCCTGCCATGGGGGCTACAAGCCTTATTATCCGGCTTGCTTGTCTTGGGGATGACTGTCCT CGTTACCCGATTGCGCGTACATGTTTCAACACGCTGGGCCTTTACCGCTACCCCACACGGGGGAAGTTCCAGCGG CTGCTCTGGGATGCAGTTGTAAATAGCGAAGGATTTGGCTTGAAATGA
Transcript	>Pro_DTO377G3_2|g6169.t1 ATGCCGTCCCGGCCTGAACGTCATCTGCCTATCCCTCCGATCTCAAGTGCTGGCAACGCCGCCATCCCTGGAATA CACCCTTCCCAATTTTCTGGACTGGAAATCAATCCACGCCGTATGGCTCGACCTCGCGATGCTTCGATCATGCCC CCATTAAACGGCGGTACCCCCAAGAGTTCGTACCACCGAGGACATTCACGCTCGATCAGCAATCCGTTCGCTGGG TTTGGGCGAAAACGGGACAAGACAGTCGCCAAGTATGCGACTTGGGACTCTGACGATGATGACGACGATGAGGTA ACATATCCCTTGGAGCCAGAGTCGTCAAGTCCCCGGAAAGGTGCAGCACCTGGAAATGATCTCGCCGAGGGCAAG TGTCAGACTTGTGATGCTACCGTCCGGTGGCCACGGCACTTGAAGGTGTTTAGATGTACCGACTGCTTGATGATC ACAGACCTCGAGCCGATTTCTCATGATTCAAAAGACAAACCCCCACAAGGGTCTCAGGGTGGAGCGTCCAATTTG GCAAGCAAAGTGTTTCCTTTGACGGCCAATCAAATTCGTGGTATGGTCGGGGGGTGTCTCAACATGTATTTCGAT AGCCTTTTGGACAATAGCCCTCGGTCATGGTTGTCGCCGGACGACGACAGAAAGAACAAACCGCTACCTAATCTT CCGCCAATGCAGGATCATGCCTCTGGTCCAAAAAATCTCTCGCCCCCACGCACTGGCGATTCTCGGAGTCGTAGT GCTTCCCATTCTAGTGAACGGGAAAGGTTGGCGGCGTCAAAAGAAAACTCAGGTTACTTGACACCACCATCTGTT CGCTGGGAGGGCAATGACACGCCTGTCAGAGTCCGAGCAAATTCAGATCTCCGATCAACTCCAAAGCTAGACAGC CGCACGCAAGACGTTTCGCAAGCCGGGAACCCGGAGTTTCAAAGCTGCGACAATCGGACACACATTTTCAAACGG CTGGAAAATACCATCGCCACTGCCTTCAAAGGCTGTGACTGCCTCAACGAATCTTTCACTACATATCCACCACCT CGGTCAGCCCGAGCAGCTAGTAATGGTAATCCACCGAAAACGAAGATGGAACCGACCACAATGCCCCAACCAGCG CAAGACGCTCCAGTTTTTGAACCAGATGCCAAAACTCTTCTTTTAGGAGATTTGACTGAGAACTCCTCTTGGTGG ATGAATGAATGGGCTGAGACCGAAGGCCAAAATCCCGCATATTCCAAAGAGAAGAACACCCCAAAGTCTCGGATG ATATCATCGCGAAGTCCTCGGATCAACTGGTCCGAGTTAGCCCAGTGGTACCATTCGATCCTGTCCGCGGGAAAT TCTTGGAATGAGCTCTGGGCCGCCAAAAAGCCTGACCCCACAAGATCAGAAGCGGATCTGATCCGAGCCAAGAGA TGGGCGTCTATTGATCCGTCCTTGATCGGAAGACAAGTCAGCGAGTCTCGTTTGCACTTACAACGGGCACTCTTG AAAGCTACCGAGGGCCTCCTCAAACGCCCGCGCCGTGTTCTGAAGAAACCAGAAGATACCAGGTTCTTGTTCATA TTGTTAGCGAATCCCATGTTGTCTTCACCTGCGTCTTATTATCAGAATACATCCATCTCGCCGTCTCATCGAGAT GAGAGGCGCCCATCGCATCCAAAAGACTACCTGAAATCGGCAACCCGAGACGGAAAACCCTTGCAGAAAGAGCCG CACAAAGCCCCTGCTCGTCTAGATGGCTCCAGTCACCATTATGGAATTATCAAACGAATCCTGGGACTCGCGTCT AATTTGCCCAATGACTGCCATCACTACATCGTGTCTTGGGCTTCCCGTTTCTCTGTTAGACATTTCGAGCGACTG GTAGAACTTATCGGTGGATTTCTCACTTACCGTTTGAGTCGCCAGCATGGGCGAAAACGCCCTCAAAATCCTCAA AACGGAGATGATCTAATACCGAGCTTTGCCAGTGCTTCGGGAAATACTGCTGCGGAACTCCACGCTGCGATTAAT CGAAGTAGCCCGAACAAGAAGCCTGGCAAAAAGACCGAAGACCCCATAATATACGCCGAGGACTGGCAGATCAGA GCAGCAGCAAGAGTAATGTCGCTGTTCTTCACGGCTAACATCTCCTCTGCAACGAGGAAGTCTGATGGAACTCCG CGCAGTCTTGAAGTTCCCAAGAACCCAGGCCCTCGTCAAGGACATATGATTCCAATCAGTGCATTCTACAATACA CTGCTGGACTATTCGGATTTAGTGGCGGACTTCGAGACTTGGGAGGCTAAAGTCTCGAAGTTTTCGTTCTGTCAG TATCCGTTCCTCCTTAGCATCTGGGCCAAAATTCATATCATGGAGCATGATGCGCGTCGTCAAATGGAAGTGAAA GCACGCGATGCATTTTTCGACAGCGTCCTCAACCACACGGCGGTTAGTCAGTACCTGGTGTTGAAGGTACGGCGT GAGTGTTTGATTGAAGACAGCCTGAAGGGAGTGAGTGAAATTGTTGGTACTGGCCAAGAAGAAATCAAAAAGGGT CTCCGGATCGAATTTTCGGGCGAAGAAGGCATTGATGCTGGCGGCCTGCGGAAGGAATGGTTTCTGCTGCTTGTT CGAGAGGTCTTTGACCCGCTTCATGGCCTCTTCATCTACGATGACGATTCGCAGTATTGCTACTTCAATCCTTAT TGCTTTGAGTCATCCGAACAATTCTTCTTGGTTGGGGTTCTTCTAGGTCTCGCCATCTACAACTCCACCATCCTT GATGTTAGTCTCCCGCCGTTTGCGTTTAAGAAATTGCTGTCGTCAGCGGGGCATGCCAACGGGCCACAACTGGCT ACTTCCTTGCGTTCGACCTTCAAATGCACCCTAGAAGATCTTGCCGAGTACCGGCCAGCTCTCGCCAAAGGACTC CGGGGTCTGCTAGAATTCGAAGGCAATGTCGCGGAGACATTCTGCTACGATTTCGTTGCCCAGGTCGATCGCTAC GGCGAGATTATCAGTGTGCCACTCTGTGCAAATGGCGAGAACCGACCGGTGACCAACTCCAACAAGCGTGAGTTT GTGGATTTGTATGTCCAATATCTGCTAGACACAGCCGTGGCTCGACAGTTCGAACCTTTCAAACGCGGTTTCTTC ACGGTCTGCGGCGGCAATGCACTATCACTATTCCGACCAGAAGAGATCGAAATGCTAGTCCGCGGCTCAGATGAA CCACTCGATGTCAATTCTCTCCGGGCGGTGGCCACCTACGACAACTGGTCACACCCACGACCAGAATCAGTCCCT GTAGTGCGCTGGTTCTGGGACTTCTTGGAGAAATCAGACCCTCAAGCACAGCGCAAGATCTTGTCATTCATTACT GGTAGCGATCGGATCCCTGCCATGGGGGCTACAAGCCTTATTATCCGGCTTGCTTGTCTTGGGGATGACTGTCCT CGTTACCCGATTGCGCGTACATGTTTCAACACGCTGGGCCTTTACCGCTACCCCACACGGGGGAAGTTCCAGCGG CTGCTCTGGGATGCAGTTGTAAATAGCGAAGGATTTGGCTTGAAATGA
Gene	>Pro_DTO377G3_2|g6169.t1 ATGCCGTCCCGGCCTGAACGTCATCTGCCTATCCCTCCGATCTCAAGTGCTGGCAACGCCGCCATCCCTGGAATA CACCCTTCCCAATTTTCTGGACTGGAAATCAATCCACGCCGTATGGCTCGACCTCGCGATGCTTCGATCATGCCC CCATTAAACGGCGGTACCCCCAAGAGTTCGTACCACCGAGGACATTCACGCTCGATCAGCAATCCGTTCGCTGGG TTTGGGCGAAAACGGGACAAGACAGTCGCCAAGTATGCGACTTGGGACTCTGACGATGATGACGACGATGAGGTA ACATATCCCTTGGAGCCAGAGTCGTCAAGTCCCCGGAAAGGTGCAGCACCTGGAAATGATCTCGCCGAGGGCAAG TGTCAGACTTGTGATGCTACCGTCCGGTGGCCACGGCACTTGAAGGTGTTTAGATGTACCGACTGCTTGATGATC ACAGACCTCGAGCCGATTTCTCATGATTCAAAAGACAAACCCCCACAAGGGTCTCAGGGTGGAGCGTCCAATTTG GCAAGCAAAGGTAACACCTCCAGATGCTAGTTTTGCGTCATATATTTGTAAAAGATACTGATTTGCTACCTAGTG TTTCCTTTGACGGCCAATCAAATTCGTGGTATGGTCGGGGGGTGTCTCAACATGTATTTCGATAGCCTTTTGGAC AATAGCCCTCGGTCATGGTTGTCGCCGGACGACGACAGAAAGAACAAACCGCTACCTAATCTTCCGCCAATGCAG GATCATGCCTCTGGTCCAAAAAATCTCTCGCCCCCACGCACTGGCGATTCTCGGAGTCGTAGTGCTTCCCATTCT AGTGAACGGGAAAGGTTGGCGGCGTCAAAAGAAAACTCAGGTTACTTGACACCACCATCTGTTCGCTGGGAGGGC AATGACACGCCTGTCAGAGTCCGAGCAAATTCAGATCTCCGATCAACTCCAAAGCTAGACAGCCGCACGCAAGAC GTTTCGCAAGCCGGGAACCCGGAGTTTCAAAGCTGCGACAATCGGACACACATTTTCAAACGGCTGGAAAATACC ATCGCCACTGCCTTCAAAGGCTGTGACTGCCTCAACGAATCTTTCACTACATATCCACCACCTCGGTCAGCCCGA GCAGCTAGTAATGGTAATCCACCGAAAACGAAGATGGAACCGACCACAATGCCCCAACCAGCGCAAGACGCTCCA GTTTTTGAACCAGATGCCAAAACTCTTCTTTTAGGAGATTTGACTGAGAACTCCTCTTGGTGGATGAATGAATGG GCTGAGACCGAAGGCCAAAATCCCGCATATTCCAAAGAGAAGAACACCCCAAAGTCTCGGATGATATCATCGCGA AGTCCTCGGATCAACTGGTCCGAGTTAGCCCAGTGGTACCATTCGATCCTGTCCGCGGGAAATTCTTGGAATGAG CTCTGGGCCGCCAAAAAGCCTGACCCCACAAGATCAGAAGCGGATCTGATCCGAGCCAAGAGATGGGCGTCTATT GATCCGTCCTTGATCGGAAGACAAGTCAGCGAGTCTCGTTTGCACTTACAACGGGCACTCTTGAAAGCTACCGAG GGCCTCCTCAAACGCCCGCGCCGTGTTCTGAAGAAACCAGAAGATACCAGGTTCTTGTTCATATTGTTAGCGAAT CCCATGTTGTCTTCACCTGCGTCTTATTATCAGAATACATCCATCTCGCCGTCTCATCGAGATGAGAGGCGCCCA TCGCATCCAAAAGACTACCTGAAATCGGCAACCCGAGACGGAAAACCCTTGCAGAAAGAGCCGCACAAAGCCCCT GCTCGTCTAGATGGCTCCAGTCACCATTATGGAATTATCAAACGAATCCTGGGACTCGCGTCTAATTTGCCCAAT GACTGCCATCACTACATCGTGTCTTGGGCTTCCCGTTTCTCTGTTAGACATTTCGAGCGACTGGTAGAACTTATC GGTGGATTTCTCACTTACCGTTTGAGTCGCCAGCATGGGCGAAAACGCCCTCAAAATCCTCAAAACGGAGATGAT CTAATACCGAGCTTTGCCAGTGCTTCGGGAAATACTGCTGCGGAACTCCACGCTGCGATTAATCGAAGTAGCCCG AACAAGAAGCCTGGCAAAAAGACCGAAGACCCCATAATATACGCCGAGGACTGGCAGATCAGAGCAGCAGCAAGA GTAATGTCGCTGTTCTTCACGGCTAACATCTCCTCTGCAACGAGGAAGTCTGATGGAACTCCGCGCAGTCTTGAA GTTCCCAAGAACCCAGGCCCTCGTCAAGGACATATGATTCCAATCAGTGCATTCTACAATACACTGCTGGACTAT TCGGATTTAGTGGCGGACTTCGAGACTTGGGAGGCTAAAGTCTCGAAGTTTTCGTTCTGTCAGTATCCGTTCCTC CTTAGCATCTGGGCCAAAATTCATATCATGGAGCATGATGCGCGTCGTCAAATGGAAGTGAAAGCACGCGATGCA TTTTTCGACAGCGTCCTCAACCACACGGCGGTTAGTCAGTACCTGGTGTTGAAGGTACGGCGTGAGTGTTTGATT GAAGACAGCCTGAAGGGAGTGAGTGAAATTGTTGGTACTGGCCAAGAAGAAATCAAAAAGGGTCTCCGGATCGAA TTTTCGGGCGAAGAAGGCATTGATGCTGGCGGCCTGCGGAAGGAATGGTTTCTGCTGCTTGTTCGAGAGGTCTTT GACCCGCTTCATGGTCAGCGTTTTCCGATCTTAGAGTGAAATGACTCGCTAATTCAAAATAGGCCTCTTCATCTA CGATGACGATTCGCAGTATTGCTACTTCAATCCTTATTGCTTTGAGTCATCCGAACAATTCTTCTTGGTTGGGGT TCTTCTAGGTCTCGCCATCTACAACTCCACCATCCTTGATGTTAGTCTCCCGCCGTTTGCGTTTAAGAAATTGCT GTCGTCAGCGGGGCATGCCAACGGGCCACAACTGGCTACTTCCTTGCGTTCGACCTTCAAATGCACCCTAGAAGA TCTTGCCGAGTACCGGCCAGCTCTCGCCAAAGGACTCCGGGGTCTGCTAGAATTCGAAGGCAATGTCGCGGAGAC ATTCTGCTACGATTTCGTTGCCCAGGTCGATCGCTACGGCGAGATTATCAGTGTGCCACTCTGTGCAAATGGCGA GAACCGACCGGTGACCAACTCCAACAAGCGTGAGTTTGTGGATTTGTATGTCCAATATCTGCTAGACACAGCCGT GGCTCGACAGTTCGAACCTTTCAAACGCGGTTTCTTCACGGTCTGCGGCGGCAATGCACTATCACTATTCCGACC AGAAGAGATCGAAATGCTAGTCCGCGGCTCAGATGAACCACTCGATGTCAATTCTCTCCGGGCGGTGGCCACCTA CGACAACTGGTCACACCCACGACCAGAATCAGTCCCTGTAGTGCGCTGGTTCTGGGACTTCTTGGAGAAATCAGA CCCTCAAGCACAGCGCAAGATCTTGTCATTCATTACTGGTAGCGATCGGATCCCTGCCATGGGGGCTACAAGCCT TATTATCCGGCTTGCTTGTCTTGGGGATGACTGTCCTCGTTACCCGATTGCGCGTACATGTTTCAACACGCTGGG CCTTTACCGCTACCCCACACGGGGGAAGTTCCAGCGGCTGCTCTGGGATGCAGTTGTAAATAGCGAAGGATTTGG CTTGAAATGA