Fungal Genomics

Agaricus bisporus var bisporus H39 Agaricus bisporus var bisporus H97 Agaricus bisporus var burnettii H119p4 Ophiocordyceps australis 1348a (Ghana) Ophiocordyceps australis map64 (Brazil) Ophiocordyceps camponoti-floridani Ophiocordyceps camponoti-rufipedis Ophiocordyceps kimflemingae Ophiocordyceps subramaniannii Penicillium roqueforti DTO002I6 Penicillium roqueforti DTO003C3 Penicillium roqueforti DTO003H1 (CBS 147308) Penicillium roqueforti DTO006G1 Penicillium roqueforti DTO006G7 Penicillium roqueforti DTO012A1 Penicillium roqueforti DTO012A2 (CBS 147309) Penicillium roqueforti DTO012A6 (CBS 147310) Penicillium roqueforti DTO012A7 Penicillium roqueforti DTO012A8 Penicillium roqueforti DTO012A9 Penicillium roqueforti DTO013E5 Penicillium roqueforti DTO013F2 Penicillium roqueforti DTO013F5 (CBS 147311) Penicillium roqueforti DTO027I6 Penicillium roqueforti DTO032C6 Penicillium roqueforti DTO039G3 Penicillium roqueforti DTO046C5 Penicillium roqueforti DTO070G2 (CBS 147317) Penicillium roqueforti DTO081F9 (CBS 147318) Penicillium roqueforti DTO101D6 (CBS 147325) Penicillium roqueforti DTO102I9 (CBS 147326) Penicillium roqueforti DTO126G2 (CBS 147330) Penicillium roqueforti DTO127F7 (CBS 147331) Penicillium roqueforti DTO127F9 (CBS 147332) Penicillium roqueforti DTO130C1 (CBS 147333) Penicillium roqueforti DTO163C3 (CBS 147337) Penicillium roqueforti DTO163F5 (CBS 147338) Penicillium roqueforti DTO163G4 (CBS 147339) Penicillium roqueforti DTO265D5 (CBS 147372) Penicillium roqueforti DTO369A1 (CBS 147354) Penicillium roqueforti DTO375B1 (CBS 147355) Penicillium roqueforti DTO377G2 (LCP 96.3914a) Penicillium roqueforti LCP96 04111 Rhodonia placenta FPRL280

General Properties

Protein ID	Pro_DTO377G3_2|g6095.t1
Gene name
Location	scaffold_15:588968..593091
Strand	-
Gene length (bp)	4123
Transcript length (bp)	4011
Coding sequence length (bp)	4011
Protein length (aa)	1337

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PFAM Domains

PFAM Domain ID	Short name	Long name	E-value	Start	End
PF00620	RhoGAP	RhoGAP domain	1.2E-41	1038	1186
PF00169	PH	PH domain	1.4E-14	723	833

GO

GO Term	Description	Terminal node
GO:0007165	signal transduction	Yes
GO:0008150	biological_process	No
GO:0009987	cellular process	No
GO:0065007	biological regulation	No
GO:0050789	regulation of biological process	No
GO:0050794	regulation of cellular process	No

SignalP

[Help with interpreting these statistics]

SignalP signal predicted	Location (based on Ymax)	D score (significance: > 0.45)
No	1 - 52	0.45

Transmembrane Domains

(None)

Transcription Factor Class

(None)

Expression data

Analysis 1: Genome-wide gene expression in conidia of Penicillium roqueforti during growth at various temperatures and for various amounts of time. Published in Punt et al., 2020.

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Sequences

Type of sequence	Sequence
Locus	Download genbank file of locus The gene with 5 kb flanks (if sufficient flanking sequence is available). For use in cloning design programs. NOTE: features (genes or exons) that are only partially contained within the sequence are completely excluded.
Protein	>Pro_DTO377G3_2|g6095.t1 MSQIPRENNESPPTSSNNRSGFPVNNGLIPRDYLARSDQRPGPTPGSRNITPSPLHTSSLPQSHRVGGSTSSDSP LSPKSNPSSAQNWSPITRVANAPYTAPPSSTGQSASQSPEMDSGNTSGRPGETNTPKSTRAPEPDRSGSSSVSSV HSMPGDRTPNRIMPRTSSIDSAISSLSSSSQRSAFDVNALSSADINNLINAAGSAEAVIVHLLKEKHQAASQNAQ LWKLVDKQRTLILGLNKDLERAFQEKEKYRKKLKDIQDAPPLPVAEPSASVTAPSSDKENVSRKPDQPSIVLASE SSRREGFEHTRSPVYAADIPSPVGDGNNRIPYPNRKPPPAPLNLRQADNDRASSASDSDSGSDYGDSQDVNGLPS AGRGRRKTREQDDQDREAALEKDMSGSTGSVEPPQTASSQSSRDTATCSPRTVPREHSTRSPPNVGDSNSLGSLL GSRPPPSSSVNGRSIAAMPLSPGLPLSPRPEDRPVNSPMPRMPRDFSTSMAAGYQAQGLPLSPRMANHPTGFAPI PSGRGPIPLIDPTIMIDSPRSANFPDNQIYRGLMSDEYQGLLLPPNALPLVQVRVSSSRLRPSRNSYMASRPLDE EPVFTLSVILRSEMSELWRVEKVIGALPQLDQKVRQSSPFSGKLPDRSIFSGHSPAKVDLRRAALNAYFDRLLDT PMDENAALAICQFLTSDAIEPRDDETSLLKGLAQTRPDMPRGPDGKPQKEGYLTKRGKNFGGWKARYFVLDGPDL RYYESPGGPHMGTIKLHHAQIGKQSPKPNENVPSPGAEDDSDNQYRHAFLVLEPKKKDSSALVRHVLCAESDEER DTWVDALMEYVENASSENEGRGSVSSKSQPQSQDESHVQQKQLLSGSETKSKIFNGSKRSGRVDSPDQDLGGSVQ GFSFEDAVPADPPTIGSSVEQAPRSPRIPTTLSTEFKDTTMSPDQTMQSPRLISRPTNGTVIQDLEAWGNKAKTS TKEKKRSIWGFRSRSSFDLANHASGDTSGHNAERTGPVRPVFGIPLAEAVQDCGLPGIDAGLPAVVYRCIEYLHA KEAALEEGIFRLSGSNVVIKALKERFNTEGDVDFVSGDQYYDIHAVASLFKQYLRELPTTVLTRELHLDFLRVLE LDDRQKKVAAFNSLVHRLPRPNLALLRALSQFLIEIVNNSDVNKMTVRNVGIVFAPTLNIPAPVFSMFLTDYDSI FGDTDSSFARPAMELTVENTLSPDDIRSPRHQMFSDLPTPSYQQTSFRPIGDGNGPSDGPRTHHDTGFTPMQPSY DQPTSSRHEQYHHHQHQSAGASYSSLNGMLGASSEDTRSAKTKRRESSMLFMEDPSFYQGK*
Coding	>Pro_DTO377G3_2|g6095.t1 ATGTCGCAAATCCCGCGGGAGAATAATGAAAGCCCGCCAACTTCATCTAATAATCGGTCCGGTTTCCCAGTCAAT AACGGTCTCATTCCGCGAGATTATTTAGCTCGATCTGATCAACGCCCCGGTCCTACTCCTGGTTCCCGAAATATC ACACCCTCCCCGTTGCATACAAGTTCCCTCCCCCAGTCGCACCGTGTCGGCGGATCTACATCATCCGACAGTCCC CTATCTCCGAAATCCAACCCTTCTTCCGCCCAGAATTGGTCGCCAATCACTCGCGTAGCCAATGCACCATACACT GCGCCACCCTCCAGTACTGGTCAAAGCGCGTCGCAATCACCAGAAATGGATTCGGGGAATACTAGCGGTCGACCT GGCGAAACCAATACGCCGAAATCAACCCGTGCGCCAGAACCAGATCGATCTGGCTCTTCCTCCGTCAGCTCTGTA CACTCGATGCCGGGTGATCGCACACCCAATCGCATCATGCCTCGCACCTCGTCAATCGATTCTGCTATCTCGTCC CTGTCCTCCAGCTCTCAGAGATCGGCCTTTGATGTCAATGCTCTGAGTTCAGCCGACATAAACAATCTCATCAAT GCCGCTGGATCTGCCGAGGCTGTGATCGTGCACCTCTTGAAAGAGAAACACCAAGCGGCCTCTCAGAACGCGCAA CTTTGGAAATTAGTGGACAAACAAAGGACTTTAATCCTCGGCCTTAACAAGGATCTAGAGCGTGCTTTTCAAGAG AAGGAGAAATATCGGAAGAAGCTTAAAGATATACAAGACGCTCCGCCATTGCCCGTTGCCGAGCCCTCGGCGTCT GTGACTGCACCGAGCAGTGACAAAGAGAATGTGTCTCGCAAACCTGACCAACCATCGATTGTCCTAGCTTCTGAA TCCTCTCGGCGGGAGGGCTTCGAACACACCAGAAGCCCAGTCTATGCCGCCGATATCCCGTCTCCGGTAGGAGAC GGAAATAACAGGATTCCGTACCCAAATCGCAAACCACCGCCTGCGCCTCTGAATCTACGACAAGCAGACAATGAC AGGGCATCTTCAGCTTCCGATTCCGATTCCGGTTCCGATTACGGCGATTCCCAGGATGTAAATGGCCTTCCGAGT GCGGGTCGTGGGCGGAGAAAGACGAGAGAGCAGGATGATCAGGACCGCGAAGCTGCGCTGGAGAAGGATATGTCT GGGTCTACCGGCTCTGTGGAACCGCCTCAGACAGCATCCTCTCAGAGCTCCCGGGATACAGCAACATGTAGCCCG AGAACAGTCCCCAGGGAGCATTCTACGAGATCACCGCCAAATGTGGGTGATTCTAACTCACTGGGGTCACTTTTG GGCTCTCGGCCCCCTCCTTCTTCGTCCGTCAATGGGCGCTCTATCGCTGCTATGCCCTTGAGCCCTGGACTGCCC TTGAGCCCGAGGCCAGAAGATCGACCCGTTAATTCTCCCATGCCGCGCATGCCACGAGACTTTTCCACTTCCATG GCAGCCGGGTATCAGGCCCAGGGATTGCCGCTCTCGCCAAGAATGGCTAATCATCCCACGGGCTTTGCTCCCATC CCTTCCGGACGTGGTCCTATTCCATTAATTGATCCCACAATCATGATTGACAGCCCGAGATCTGCAAATTTCCCC GACAATCAAATCTACCGAGGTTTGATGTCTGATGAATACCAGGGCCTGCTTTTACCTCCGAATGCCCTTCCTCTG GTTCAAGTCAGGGTATCTTCGTCGCGGCTTCGACCTTCCCGGAATAGTTACATGGCGTCGAGGCCCCTGGACGAG GAGCCTGTTTTTACTCTCAGTGTGATCCTGCGGTCAGAAATGTCAGAGCTATGGCGAGTTGAAAAGGTCATCGGT GCTTTACCACAGCTGGATCAAAAAGTCCGACAATCTTCTCCGTTTTCCGGAAAATTACCGGATAGGAGCATTTTC AGCGGACACTCCCCTGCTAAGGTTGACCTGAGACGTGCCGCACTGAATGCGTACTTTGACAGACTGTTGGACACG CCAATGGACGAGAATGCCGCGCTAGCTATCTGCCAATTTTTGACAAGTGATGCCATAGAACCTCGAGACGACGAG ACAAGTTTGCTGAAAGGTCTCGCCCAGACAAGGCCCGACATGCCACGTGGACCAGACGGAAAGCCTCAAAAGGAA GGTTACTTGACCAAACGAGGCAAGAACTTCGGTGGCTGGAAAGCGAGATATTTCGTTCTCGATGGACCTGATCTG AGATACTACGAATCTCCCGGTGGTCCGCACATGGGTACTATTAAACTTCATCATGCCCAGATCGGCAAGCAATCG CCAAAACCCAACGAGAATGTTCCATCTCCTGGGGCCGAGGATGATTCTGATAACCAGTATCGCCATGCCTTTCTG GTATTGGAACCAAAGAAGAAGGATTCTTCGGCACTTGTTCGGCATGTTCTCTGCGCCGAGAGCGACGAGGAGCGT GATACGTGGGTTGATGCTCTCATGGAATATGTTGAGAATGCTTCTTCCGAAAATGAGGGACGTGGCAGCGTATCT TCCAAGAGTCAGCCTCAGTCTCAAGATGAATCCCACGTGCAGCAAAAGCAACTACTCTCCGGATCCGAGACCAAG TCTAAAATATTCAACGGAAGCAAGAGATCTGGTCGAGTTGATAGTCCCGACCAGGATCTAGGAGGCTCTGTGCAG GGTTTCAGCTTTGAGGATGCAGTGCCAGCTGATCCTCCGACTATTGGTTCCAGTGTTGAGCAAGCTCCCCGGTCC CCACGAATCCCGACGACGTTGTCGACAGAATTCAAGGACACGACGATGTCTCCCGACCAAACAATGCAGTCTCCC AGATTGATATCTAGGCCCACAAACGGCACGGTCATTCAAGACCTGGAGGCTTGGGGCAACAAAGCAAAGACATCG ACGAAAGAGAAGAAACGTAGTATCTGGGGTTTCCGGTCCAGGTCTTCTTTCGACCTTGCCAACCACGCCAGCGGC GATACATCAGGCCACAATGCTGAGAGGACGGGTCCTGTTAGACCTGTATTTGGTATACCCTTGGCAGAGGCCGTG CAAGATTGCGGACTGCCAGGCATTGATGCAGGGCTGCCGGCAGTGGTTTATCGCTGCATTGAATATCTCCATGCC AAGGAAGCTGCCTTGGAGGAAGGTATCTTCCGTCTGAGCGGTTCCAATGTGGTGATTAAAGCGTTGAAAGAACGT TTCAACACTGAAGGTGATGTTGATTTCGTGTCTGGAGATCAGTATTACGACATTCATGCTGTGGCTTCTCTCTTC AAGCAATATCTTCGAGAGCTTCCGACGACAGTCTTAACTAGGGAGCTTCATTTGGACTTCCTTCGCGTTCTCGAA CTTGACGACCGTCAAAAGAAGGTCGCTGCCTTCAACTCTCTAGTGCATAGGCTGCCTAGACCCAATCTCGCATTG CTACGAGCTCTATCGCAATTCTTGATCGAGATTGTGAACAATTCCGATGTGAACAAGATGACGGTCAGGAACGTG GGCATTGTCTTTGCCCCAACTCTCAATATTCCGGCACCGGTCTTCTCGATGTTCCTCACGGACTACGACAGTATC TTTGGCGATACTGATTCGAGCTTTGCGAGGCCGGCTATGGAACTGACAGTTGAAAACACTCTGTCGCCCGATGAT ATTCGTTCCCCACGTCATCAAATGTTCTCAGACCTCCCTACACCTTCGTACCAGCAGACTTCGTTCCGACCCATT GGTGATGGCAACGGTCCTTCCGATGGCCCCAGGACACACCACGACACTGGTTTCACTCCAATGCAACCTAGCTAT GACCAACCGACGTCTTCCAGACATGAGCAATACCACCACCATCAACATCAGAGTGCCGGCGCTTCGTATTCTTCC TTGAATGGCATGTTGGGGGCTAGCTCGGAAGACACTCGCTCGGCAAAGACCAAGCGACGGGAGAGTTCAATGCTC TTTATGGAGGATCCTTCTTTCTACCAGGGCAAGTGA
Transcript	>Pro_DTO377G3_2|g6095.t1 ATGTCGCAAATCCCGCGGGAGAATAATGAAAGCCCGCCAACTTCATCTAATAATCGGTCCGGTTTCCCAGTCAAT AACGGTCTCATTCCGCGAGATTATTTAGCTCGATCTGATCAACGCCCCGGTCCTACTCCTGGTTCCCGAAATATC ACACCCTCCCCGTTGCATACAAGTTCCCTCCCCCAGTCGCACCGTGTCGGCGGATCTACATCATCCGACAGTCCC CTATCTCCGAAATCCAACCCTTCTTCCGCCCAGAATTGGTCGCCAATCACTCGCGTAGCCAATGCACCATACACT GCGCCACCCTCCAGTACTGGTCAAAGCGCGTCGCAATCACCAGAAATGGATTCGGGGAATACTAGCGGTCGACCT GGCGAAACCAATACGCCGAAATCAACCCGTGCGCCAGAACCAGATCGATCTGGCTCTTCCTCCGTCAGCTCTGTA CACTCGATGCCGGGTGATCGCACACCCAATCGCATCATGCCTCGCACCTCGTCAATCGATTCTGCTATCTCGTCC CTGTCCTCCAGCTCTCAGAGATCGGCCTTTGATGTCAATGCTCTGAGTTCAGCCGACATAAACAATCTCATCAAT GCCGCTGGATCTGCCGAGGCTGTGATCGTGCACCTCTTGAAAGAGAAACACCAAGCGGCCTCTCAGAACGCGCAA CTTTGGAAATTAGTGGACAAACAAAGGACTTTAATCCTCGGCCTTAACAAGGATCTAGAGCGTGCTTTTCAAGAG AAGGAGAAATATCGGAAGAAGCTTAAAGATATACAAGACGCTCCGCCATTGCCCGTTGCCGAGCCCTCGGCGTCT GTGACTGCACCGAGCAGTGACAAAGAGAATGTGTCTCGCAAACCTGACCAACCATCGATTGTCCTAGCTTCTGAA TCCTCTCGGCGGGAGGGCTTCGAACACACCAGAAGCCCAGTCTATGCCGCCGATATCCCGTCTCCGGTAGGAGAC GGAAATAACAGGATTCCGTACCCAAATCGCAAACCACCGCCTGCGCCTCTGAATCTACGACAAGCAGACAATGAC AGGGCATCTTCAGCTTCCGATTCCGATTCCGGTTCCGATTACGGCGATTCCCAGGATGTAAATGGCCTTCCGAGT GCGGGTCGTGGGCGGAGAAAGACGAGAGAGCAGGATGATCAGGACCGCGAAGCTGCGCTGGAGAAGGATATGTCT GGGTCTACCGGCTCTGTGGAACCGCCTCAGACAGCATCCTCTCAGAGCTCCCGGGATACAGCAACATGTAGCCCG AGAACAGTCCCCAGGGAGCATTCTACGAGATCACCGCCAAATGTGGGTGATTCTAACTCACTGGGGTCACTTTTG GGCTCTCGGCCCCCTCCTTCTTCGTCCGTCAATGGGCGCTCTATCGCTGCTATGCCCTTGAGCCCTGGACTGCCC TTGAGCCCGAGGCCAGAAGATCGACCCGTTAATTCTCCCATGCCGCGCATGCCACGAGACTTTTCCACTTCCATG GCAGCCGGGTATCAGGCCCAGGGATTGCCGCTCTCGCCAAGAATGGCTAATCATCCCACGGGCTTTGCTCCCATC CCTTCCGGACGTGGTCCTATTCCATTAATTGATCCCACAATCATGATTGACAGCCCGAGATCTGCAAATTTCCCC GACAATCAAATCTACCGAGGTTTGATGTCTGATGAATACCAGGGCCTGCTTTTACCTCCGAATGCCCTTCCTCTG GTTCAAGTCAGGGTATCTTCGTCGCGGCTTCGACCTTCCCGGAATAGTTACATGGCGTCGAGGCCCCTGGACGAG GAGCCTGTTTTTACTCTCAGTGTGATCCTGCGGTCAGAAATGTCAGAGCTATGGCGAGTTGAAAAGGTCATCGGT GCTTTACCACAGCTGGATCAAAAAGTCCGACAATCTTCTCCGTTTTCCGGAAAATTACCGGATAGGAGCATTTTC AGCGGACACTCCCCTGCTAAGGTTGACCTGAGACGTGCCGCACTGAATGCGTACTTTGACAGACTGTTGGACACG CCAATGGACGAGAATGCCGCGCTAGCTATCTGCCAATTTTTGACAAGTGATGCCATAGAACCTCGAGACGACGAG ACAAGTTTGCTGAAAGGTCTCGCCCAGACAAGGCCCGACATGCCACGTGGACCAGACGGAAAGCCTCAAAAGGAA GGTTACTTGACCAAACGAGGCAAGAACTTCGGTGGCTGGAAAGCGAGATATTTCGTTCTCGATGGACCTGATCTG AGATACTACGAATCTCCCGGTGGTCCGCACATGGGTACTATTAAACTTCATCATGCCCAGATCGGCAAGCAATCG CCAAAACCCAACGAGAATGTTCCATCTCCTGGGGCCGAGGATGATTCTGATAACCAGTATCGCCATGCCTTTCTG GTATTGGAACCAAAGAAGAAGGATTCTTCGGCACTTGTTCGGCATGTTCTCTGCGCCGAGAGCGACGAGGAGCGT GATACGTGGGTTGATGCTCTCATGGAATATGTTGAGAATGCTTCTTCCGAAAATGAGGGACGTGGCAGCGTATCT TCCAAGAGTCAGCCTCAGTCTCAAGATGAATCCCACGTGCAGCAAAAGCAACTACTCTCCGGATCCGAGACCAAG TCTAAAATATTCAACGGAAGCAAGAGATCTGGTCGAGTTGATAGTCCCGACCAGGATCTAGGAGGCTCTGTGCAG GGTTTCAGCTTTGAGGATGCAGTGCCAGCTGATCCTCCGACTATTGGTTCCAGTGTTGAGCAAGCTCCCCGGTCC CCACGAATCCCGACGACGTTGTCGACAGAATTCAAGGACACGACGATGTCTCCCGACCAAACAATGCAGTCTCCC AGATTGATATCTAGGCCCACAAACGGCACGGTCATTCAAGACCTGGAGGCTTGGGGCAACAAAGCAAAGACATCG ACGAAAGAGAAGAAACGTAGTATCTGGGGTTTCCGGTCCAGGTCTTCTTTCGACCTTGCCAACCACGCCAGCGGC GATACATCAGGCCACAATGCTGAGAGGACGGGTCCTGTTAGACCTGTATTTGGTATACCCTTGGCAGAGGCCGTG CAAGATTGCGGACTGCCAGGCATTGATGCAGGGCTGCCGGCAGTGGTTTATCGCTGCATTGAATATCTCCATGCC AAGGAAGCTGCCTTGGAGGAAGGTATCTTCCGTCTGAGCGGTTCCAATGTGGTGATTAAAGCGTTGAAAGAACGT TTCAACACTGAAGGTGATGTTGATTTCGTGTCTGGAGATCAGTATTACGACATTCATGCTGTGGCTTCTCTCTTC AAGCAATATCTTCGAGAGCTTCCGACGACAGTCTTAACTAGGGAGCTTCATTTGGACTTCCTTCGCGTTCTCGAA CTTGACGACCGTCAAAAGAAGGTCGCTGCCTTCAACTCTCTAGTGCATAGGCTGCCTAGACCCAATCTCGCATTG CTACGAGCTCTATCGCAATTCTTGATCGAGATTGTGAACAATTCCGATGTGAACAAGATGACGGTCAGGAACGTG GGCATTGTCTTTGCCCCAACTCTCAATATTCCGGCACCGGTCTTCTCGATGTTCCTCACGGACTACGACAGTATC TTTGGCGATACTGATTCGAGCTTTGCGAGGCCGGCTATGGAACTGACAGTTGAAAACACTCTGTCGCCCGATGAT ATTCGTTCCCCACGTCATCAAATGTTCTCAGACCTCCCTACACCTTCGTACCAGCAGACTTCGTTCCGACCCATT GGTGATGGCAACGGTCCTTCCGATGGCCCCAGGACACACCACGACACTGGTTTCACTCCAATGCAACCTAGCTAT GACCAACCGACGTCTTCCAGACATGAGCAATACCACCACCATCAACATCAGAGTGCCGGCGCTTCGTATTCTTCC TTGAATGGCATGTTGGGGGCTAGCTCGGAAGACACTCGCTCGGCAAAGACCAAGCGACGGGAGAGTTCAATGCTC TTTATGGAGGATCCTTCTTTCTACCAGGGCAAGTGA
Gene	>Pro_DTO377G3_2|g6095.t1 ATGTCGCAAATCCCGCGGGAGAATAATGAAAGCCCGCCAACTTCATCTAATAATCGGTCCGGTTTCCCAGTCAAT AACGGTCTCATTCCGCGAGATTATTTAGCTCGATCTGATCAACGCCCCGGTCCTACTCCTGGTTCCCGAAATATC ACACCCTCCCCGTTGCATACAAGTTCCCTCCCCCAGTCGCACCGTGTCGGCGGATCTACATCATCCGACAGTCCC CTATCTCCGAAATCCAACCCTTCTTCCGCCCAGAATTGGTCGCCAATCACTCGCGTAGCCAATGCACCATACACT GCGCCACCCTCCAGTACTGGTCAAAGCGCGTCGCAATCACCAGAAATGGATTCGGGGAATACTAGCGGTCGACCT GGCGAAACCAATACGCCGAAATCAACCCGTGCGCCAGAACCAGATCGATCTGGCTCTTCCTCCGTCAGCTCTGTA CACTCGATGCCGGGTGATCGCACACCCAATCGCATCATGCCTCGCACCTCGTCAATCGATTCTGCTATCTCGTCC CTGTCCTCCAGCTCTCAGAGATCGGCCTTTGATGTCAATGCTCTGAGTTCAGCCGACATAAACAATCTCATCAAT GCCGCTGGATCTGCCGAGGCTGTGATCGTGCACCTCTTGAAAGAGAAACACCAAGCGGCCTCTCAGAACGCGCAA CTTTGGAAATTAGTGGACAAACAAAGGACTTTAATCCTCGGCCTTAACAAGGATCTAGAGCGTGCTTTTCAAGAG AAGGAGAAATATCGGAAGAAGCTTAAAGATATACAAGACGCTCCGCCATTGCCCGTTGCCGAGCCCTCGGCGTCT GTGACTGCACCGAGCAGTGACAAAGAGAATGTGTCTCGCAAACCTGACCAACCATCGATTGTCCTAGCTTCTGAA TCCTCTCGGCGGGAGGGCTTCGAACACACCAGAAGCCCAGTCTATGCCGCCGATATCCCGTCTCCGGTAGGAGAC GGAAATAACAGGATTCCGTACCCAAATCGCAAACCACCGCCTGCGCCTCTGAATCTACGACAAGCAGACAATGAC AGGGCATCTTCAGCTTCCGATTCCGATTCCGGTTCCGATTACGGCGATTCCCAGGATGTAAATGGCCTTCCGAGT GCGGGTCGTGGGCGGAGAAAGACGAGAGAGCAGGATGATCAGGACCGCGAAGCTGCGCTGGAGAAGGATATGTCT GGGTCTACCGGCTCTGTGGAACCGCCTCAGACAGCATCCTCTCAGAGCTCCCGGGATACAGCAACATGTAGCCCG AGAACAGTCCCCAGGGAGCATTCTACGAGATCACCGCCAAATGTGGGTGATTCTAACTCACTGGGGTCACTTTTG GGCTCTCGGCCCCCTCCTTCTTCGTCCGTCAATGGGCGCTCTATCGCTGCTATGCCCTTGAGCCCTGGACTGCCC TTGAGCCCGAGGCCAGAAGATCGACCCGTTAATTCTCCCATGCCGCGCATGCCACGAGACTTTTCCACTTCCATG GCAGCCGGGTATCAGGCCCAGGGATTGCCGCTCTCGCCAAGAATGGCTAATCATCCCACGGGCTTTGCTCCCATC CCTTCCGGACGTGGTCCTATTCCATTAATTGATCCCACAATCATGATTGACAGCCCGAGATCTGCAAATTTCCCC GACAATCAAATCTACCGAGGTTTGATGTCTGATGAATACCAGGGCCTGCTTTTACCTCCGAATGCCCTTCCTCTG GTTCAAGTCAGGGTATCTTCGTCGCGGCTTCGACCTTCCCGGAATAGTTACATGGCGTCGAGGCCCCTGGACGAG GAGCCTGTTTTTACTCTCAGTGTGATCCTGCGGTCAGAAATGTCAGAGCTATGGCGAGTTGAAAAGGTCATCGGT GCTTTACCACAGCTGGATCAAAAAGTCCGACAATCTTCTCCGTTTTCCGGAAAATTACCGGATAGGAGCATTTTC AGCGGACACTCCCCTGCTAAGGTTGACCTGAGACGTGCCGCACTGAATGCGTACTTTGACAGACTGTTGGACACG CCAATGGACGAGAATGCCGCGCTAGCTATCTGCCAATTTTTGACAAGTGATGCCATAGAACCTCGAGACGACGAG ACAAGTTTGCTGAAAGGTCTCGCCCAGACAAGGCCCGACATGCCACGTGGACCAGACGGAAAGCCTCAAAAGGAA GGTTACTTGACCAAACGAGGCAAGAACTTCGGTGGCTGGAAAGCGAGATATTTCGTTCTCGATGGACCTGATCTG AGATACTACGAATCTCCCGGTGGTCCGCACATGGGTACTATTAAACTTCATCATGCCCAGATCGGCAAGCAATCG CCAAAACCCAACGAGAATGTTCCATCTCCTGGGGCCGAGGATGATTCTGATAACCAGTATCGCCATGCCTTTCTG GTATTGGAACCAAAGAAGAAGGATTCTTCGGCACTTGTTCGGCATGTTCTCTGCGCCGAGAGCGACGAGGAGCGT GATACGTGGGTTGATGCTCTCATGGAATATGTTGAGAATGCTTCTTCCGAAAATGAGGGACGTGGCAGCGTATCT TCCAAGAGTCAGCCTCAGTCTCAAGATGAATCCCACGTGCAGCAAAAGCAACTACTCTCCGGATCCGAGACCAAG TCTAAAATATTCAACGGAAGCAAGAGATCTGGTCGAGTTGATAGTCCCGACCAGGATCTAGGAGGCTCTGTGCAG GGTTTCAGCTTTGAGGATGCAGTGCCAGCTGATCCTCCGACTATTGGTTCCAGTGTTGAGCAAGCTCCCCGGTCC CCACGAATCCCGACGACGTTGTCGACAGAATTCAAGGACACGACGATGTCTCCCGACCAAACAATGCAGTCTCCC AGATTGATATCTAGGCCCACAAACGGCACGGTCATTCAAGACCTGGAGGCTTGGGGCAACAAAGCAAAGACATCG ACGAAAGAGAAGAAACGTAGTATCTGGGGTTTCCGGTCCAGGTCTTCTTTCGACCTTGCCAACCACGCCAGCGGC GATACATCAGGCCACAATGCTGAGAGGACGGGTCCTGTTAGACCTGTATTTGGTATACCCTTGGCAGAGGCCGTG CAAGATTGCGGACTGCCAGGCATTGATGCAGGGCTGCCGGCAGTGGTTTATCGCTGCATTGAATATCTCCATGCC AAGGAAGCTGCCTTGGAGGAAGGTATCTTCCGTCTGAGCGGTTCCAATGTGGTGATTAAAGCGTTGAAAGAACGT TTCAACACTGAAGGTGATGTTGATTTCGTGTCTGGAGATCAGTATTACGACATTCATGCTGTGGCTTCTCTCTTC AAGCAATATCTTCGAGAGCTTCCGACGACAGTCTTAACTAGGGAGCTTCATTTGGACTTCCTTCGCGTTCTCGGT ATGTACACATTTGGTGTTCTCTTTTTTTTTTTTACTAACCTGATTGAAAAGAACTTGACGACCGTCAAAAGAAGG TCGCTGCCTTCAACTCTCTAGTGCATAGGCTGCCTAGACCCAATCTCGCATTGCTACGAGCTCTATCGCAATTCT TGATCGAGATTGTGAACAATTCCGATGTGAACAAGATGACGGTCAGGAACGTGGGCATTGTCTTTGCCCCAACTC TCAATATTCCGGCACCGGTCTTCTCGATGTTCCTCACGGACTACGACAGTATCTTTGGCGATACTGATTCGAGCT TTGCGAGGCCGGCTATGGAACTGACAGTTGAAAACACTCTGTCGCCCGATGATATTCGTTCCCCACGTCATCAAA TGTTCTCAGACCTCCCTACACCTTCGTACCAGCAGACTTCGTTCCGACCCATTGGTGATGGCAACGGTCCTTCCG ATGGCCCCAGGACACACCACGACACTGGTTTCACTCCAATGCAACCTAGCTATGACCAACCGACGTCTTCCAGAC ATGAGCAATACCACCACCATCAACATCAGAGTGCCGGCGCTTCGTATTCTTCCTTGAATGGCATGTTGGGGGCTA GCTCGGAAGACACTCGCTCGGCAAAGACCAAGCGACGGGAGAGTTCAATGCTCTTTATGGAGGGTAAGACCCAAG CACGAGAATATTCCCACGGACTTTACTAATCTGTACTGTCTATGAAGATCCTTCTTTCTACCAGGGCAAGTGA