Fungal Genomics

Agaricus bisporus var bisporus H39 Agaricus bisporus var bisporus H97 Agaricus bisporus var burnettii H119p4 Aspergillus niger CBS 112.32 Aspergillus niger CBS 113.50 Aspergillus niger CBS 115988 Aspergillus niger CBS 115989 Aspergillus niger CBS 118.52 Aspergillus niger CBS 124.48 Aspergillus niger CBS 131.52 Aspergillus niger CBS 133816 Aspergillus niger CBS 147320 Aspergillus niger CBS 147321 Aspergillus niger CBS 147322 Aspergillus niger CBS 147323 Aspergillus niger CBS 147324 Aspergillus niger CBS 147343 Aspergillus niger CBS 147344 Aspergillus niger CBS 147345 Aspergillus niger CBS 147346 Aspergillus niger CBS 147347 Aspergillus niger CBS 147352 Aspergillus niger CBS 147353 Aspergillus niger CBS 147371 Aspergillus niger CBS 147482 Aspergillus niger CBS 630.78 Aspergillus niger CBS 769.97 Ophiocordyceps australis 1348a (Ghana) Ophiocordyceps australis map64 (Brazil) Ophiocordyceps camponoti-floridani Ophiocordyceps camponoti-rufipedis Ophiocordyceps kimflemingae Ophiocordyceps subramaniannii Penicillium roqueforti DTO002I6 Penicillium roqueforti DTO003C3 Penicillium roqueforti DTO003H1 (CBS 147308) Penicillium roqueforti DTO006G1 Penicillium roqueforti DTO006G7 Penicillium roqueforti DTO012A1 Penicillium roqueforti DTO012A2 (CBS 147309) Penicillium roqueforti DTO012A6 (CBS 147310) Penicillium roqueforti DTO012A7 Penicillium roqueforti DTO012A8 Penicillium roqueforti DTO012A9 Penicillium roqueforti DTO013E5 Penicillium roqueforti DTO013F2 Penicillium roqueforti DTO013F5 (CBS 147311) Penicillium roqueforti DTO027I6 Penicillium roqueforti DTO032C6 Penicillium roqueforti DTO039G3 Penicillium roqueforti DTO046C5 Penicillium roqueforti DTO070G2 (CBS 147317) Penicillium roqueforti DTO081F9 (CBS 147318) Penicillium roqueforti DTO101D6 (CBS 147325) Penicillium roqueforti DTO102I9 (CBS 147326) Penicillium roqueforti DTO126G2 (CBS 147330) Penicillium roqueforti DTO127F7 (CBS 147331) Penicillium roqueforti DTO127F9 (CBS 147332) Penicillium roqueforti DTO130C1 (CBS 147333) Penicillium roqueforti DTO163C3 (CBS 147337) Penicillium roqueforti DTO163F5 (CBS 147338) Penicillium roqueforti DTO163G4 (CBS 147339) Penicillium roqueforti DTO265D5 (CBS 147372) Penicillium roqueforti DTO369A1 (CBS 147354) Penicillium roqueforti DTO375B1 (CBS 147355) Penicillium roqueforti DTO377G2 (LCP 96.3914a) Penicillium roqueforti LCP96 04111 Rhodonia placenta FPRL280

General Properties

Protein ID	Pro_DTO377G3_2|g5444.t1
Gene name
Location	scaffold_13:129535..133090
Strand	+
Gene length (bp)	3555
Transcript length (bp)	3507
Coding sequence length (bp)	3507
Protein length (aa)	1169

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PFAM Domains

PFAM Domain ID	Short name	Long name	E-value	Start	End
PF12796	Ank_2	Ankyrin repeats (3 copies)	4.6E-08	876	937
PF12796	Ank_2	Ankyrin repeats (3 copies)	8.2E-11	947	1034
PF12796	Ank_2	Ankyrin repeats (3 copies)	9.8E-15	1044	1136
PF13637	Ank_4	Ankyrin repeats (many copies)	4.9E-06	877	928
PF13637	Ank_4	Ankyrin repeats (many copies)	4.4E-06	1008	1059
PF13637	Ank_4	Ankyrin repeats (many copies)	6.2E-07	1041	1094
PF13637	Ank_4	Ankyrin repeats (many copies)	1.1E-06	1077	1127
PF13637	Ank_4	Ankyrin repeats (many copies)	1.1E-04	1109	1160
PF00023	Ank	Ankyrin repeat	1.2E-03	877	904
PF00023	Ank	Ankyrin repeat	1.4E-02	1077	1103
PF00023	Ank	Ankyrin repeat	9.5E-03	1110	1136
PF17100	NACHT_N	N-terminal domain of NWD NACHT-NTPase	6.7E-26	116	320

GO

GO Term	Description	Terminal node
GO:0005515	protein binding	Yes
GO:0005488	binding	No
GO:0003674	molecular_function	No

SignalP

[Help with interpreting these statistics]

SignalP signal predicted	Location (based on Ymax)	D score (significance: > 0.45)
No	1 - 11	0.45

Transmembrane Domains

(None)

Transcription Factor Class

(None)

Expression data

Analysis 1: Genome-wide gene expression in conidia of Penicillium roqueforti during growth at various temperatures and for various amounts of time. Published in Punt et al., 2020.

Expression values

Label	Description	Expression (RPKM)	Confidence interval (low)	Confidence interval (high)
3d_25C	Three days - 25 degrees Celsius	1.74	0.55	2.93
5d_25C	Five days - 25 degrees Celsius	1.85	0.59	3.10
7d_25C	Seven days - 25 degrees Celsius	2.12	0.72	3.53
10d_25C	Ten days - 25 degrees Celsius	2.29	0.80	3.78
7d_15C	Seven days - 15 degrees Celsius	1.81	0.55	3.06
7d_30C	Seven days - 30 degrees Celsius	3.95	1.65	6.25

Differential expression

Label1	Label2	Q-value	Significant difference
3d_25C	5d_25C	0.921148	no
3d_25C	7d_25C	0.674702	no
3d_25C	7d_15C	0.945661	no
3d_25C	7d_30C	0.013513	yes
3d_25C	10d_25C	0.533069	no
5d_25C	7d_25C	0.780180	no
5d_25C	7d_15C	0.973462	no
5d_25C	7d_30C	0.028871	yes
5d_25C	10d_25C	0.644347	no
7d_25C	7d_15C	0.741075	no
7d_25C	7d_30C	0.060938	no
7d_25C	10d_25C	0.885476	no
7d_15C	7d_30C	0.019886	yes
7d_15C	10d_25C	0.599120	no
7d_30C	10d_25C	0.110419	no

Sequences

Type of sequence	Sequence
Locus	Download genbank file of locus The gene with 5 kb flanks (if sufficient flanking sequence is available). For use in cloning design programs. NOTE: features (genes or exons) that are only partially contained within the sequence are completely excluded.
Protein	>Pro_DTO377G3_2|g5444.t1 MEDPDRKMGKSTKMTNKLAAKLAKWRKKEKPDRTRGGALVVSPTAESNTSEPSMVNYVQPSDGLTGNPDKLSKPA LVTSNTMPVSSLFEPLSLETTDVQPENFIPGPSSSPTTEDTWARAYKLLQAREPELVKDYQTHLSLAQPENSEHI NLSNPHSVERVIKQLLEVRDQKQWRVSLVGKEVKIREQAEKLVKFLLWAEPAVKKAVSTQPYAALAWAGVSLLLP LLTSSTTSNLAMLEGFDSIDHVQIYWDICEKTYLQSKDGEEYQALIQPLAKVYSFILEYQARAICHFSKAQVSRA WENMTGESNWGKIRLTIEQLSDNCRSYVSPLKLGEVRRHRDRQLLEIKESRVILDGILDVLKADTSRNQKNYKDQ NERGFLQALASDYEDGKNYNPLRIPGTCDWFLQGDVLRNWRDNDRSSLLWISAGPGCGKSVLSRALIDENRLSTN ISTSTVCYFFFKDGDERRVSATDALCALLHQLFTHDSTGTLIQNAMPSHKNHGPNLVQNFSELWRLFIQCVSSPE VGEIVCVLDALDECNDHSSRQLIRKLRELYSEPQVSSLTSKLKFLITGRPYDHLEASFQDFPDTTTCVRLDGDEK TAEISNDIDLVIDARLQNLAQNLLESDRQMISDQLKSMENRTYLWLHLTFDIIEHSRSEYGRLSDMKELFSGLPS KVSEAYEKILDRSGEKLQTENLLQIVLAASRPLSLDEANIALTMALRKGTFSSYDDLQKDSWPRDNFKGVVENLC GLFINVYDSKLFFIHQTARDFLINPPRSGKWKGRLSMQHSHANMALLCLSFLSFLDGQSSVEQIEAKFPLARYSA QHWMDHARPAETENEVQKSVMEFFLQENQAWGELFESIYYRRSYGRPHILATPLYYASSFGLQQTAQLLLAKGAD VNAQIDNYGSALQAASDRGYIEIVELLLAHGAEINAQGGIYGNALEAASSGGHKEIMGLLLANGAGVNTQGSYGS ALQAASVSGHTEIAELLLANGAETNTQGGFYGSVLQAASVNGHTEIAELLLANGADIRTQGGLYGGALQAASSNG HKEMVELLLANGAEIDVNAQGGLDGNALQAASANGHKEIVELLLAHGAEINTQGGFYGSALQAASACGHKEVVEL LLAKGAEINAQGGLYGSSFQAASACGHKEVVELLLAKGAEINA*
Coding	>Pro_DTO377G3_2|g5444.t1 ATGGAAGACCCAGACCGGAAAATGGGTAAAAGTACAAAGATGACCAACAAACTGGCGGCGAAGCTAGCGAAATGG AGAAAGAAGGAGAAACCCGATAGAACACGTGGAGGTGCCCTTGTCGTCTCTCCGACCGCAGAGTCAAACACGTCC GAGCCTTCTATGGTAAACTATGTACAGCCTTCAGATGGCCTTACTGGAAATCCCGACAAGCTCTCCAAACCTGCT TTGGTGACTTCCAATACCATGCCGGTCTCAAGTCTTTTCGAGCCCCTCTCGCTGGAAACGACCGACGTGCAGCCC GAAAATTTCATACCCGGTCCATCATCTTCTCCTACGACCGAAGACACCTGGGCCCGGGCATATAAACTCTTGCAG GCTCGAGAGCCCGAGTTGGTAAAAGATTATCAGACTCATTTGAGCCTAGCGCAACCCGAGAACTCAGAGCACATA AATCTCTCAAATCCACACTCAGTTGAGCGGGTGATAAAGCAGCTGCTGGAAGTTCGGGACCAGAAGCAGTGGCGA GTCTCACTAGTGGGAAAGGAGGTGAAGATACGAGAGCAAGCCGAAAAACTAGTTAAGTTTCTCCTCTGGGCCGAA CCAGCCGTGAAGAAAGCCGTTAGCACCCAGCCATATGCAGCATTGGCGTGGGCTGGCGTTTCGCTGCTCTTACCT CTTCTCACAAGCAGTACCACTAGCAATCTTGCGATGCTTGAAGGCTTCGATTCCATTGATCATGTTCAGATCTAC TGGGATATCTGCGAGAAGACATACTTGCAGTCCAAGGATGGGGAAGAGTATCAAGCTCTCATCCAACCCCTTGCT AAGGTCTACTCTTTTATACTCGAATACCAAGCACGTGCTATCTGTCATTTCTCAAAAGCTCAAGTCTCTCGCGCA TGGGAGAACATGACGGGTGAAAGCAATTGGGGAAAAATAAGATTAACAATCGAACAATTGAGCGATAACTGTAGG AGCTATGTCTCCCCCCTCAAACTTGGGGAGGTTCGCCGTCATCGAGATCGTCAATTACTGGAGATTAAAGAGTCT CGGGTTATTCTTGATGGCATTTTGGATGTCCTAAAAGCGGACACGAGTCGGAACCAGAAGAATTATAAAGACCAG AACGAGCGAGGGTTTCTTCAAGCACTTGCGTCCGACTACGAGGATGGCAAGAATTATAACCCACTGAGAATCCCA GGGACATGCGATTGGTTCTTACAGGGTGACGTACTTCGAAACTGGCGGGATAACGACCGCTCCAGTCTTCTGTGG ATTTCCGCTGGGCCTGGCTGTGGAAAGTCGGTGTTGTCACGGGCTCTCATTGACGAGAATCGGCTTTCTACGAAT ATTTCGACATCTACTGTCTGCTATTTCTTTTTCAAAGATGGGGATGAGCGCCGCGTGTCAGCCACTGATGCTTTG TGCGCATTGCTTCACCAACTTTTCACCCACGATTCGACGGGCACACTGATCCAAAATGCAATGCCCAGCCACAAA AATCACGGCCCAAATCTAGTACAGAACTTCTCTGAGCTGTGGCGTCTGTTCATCCAATGCGTCAGCTCGCCAGAG GTTGGAGAGATAGTTTGTGTCCTTGATGCCCTGGATGAATGCAATGATCATAGCAGTCGGCAATTGATCCGCAAA CTAAGGGAGCTTTACTCCGAGCCCCAAGTTTCATCTTTAACCTCGAAACTGAAGTTTCTGATCACTGGTCGCCCT TATGATCACCTGGAGGCATCGTTCCAAGATTTCCCTGATACAACAACTTGTGTGCGCTTGGACGGAGATGAAAAG ACCGCCGAAATCAGCAACGATATAGATCTGGTCATCGATGCTAGACTACAAAACCTCGCCCAAAACCTCCTAGAG AGCGACCGTCAAATGATTTCAGATCAACTCAAGAGCATGGAGAATCGTACTTACCTCTGGCTACATCTCACTTTC GATATTATTGAGCATAGCCGGAGTGAGTATGGTCGACTGTCCGATATGAAAGAACTATTCTCTGGGCTGCCTTCT AAGGTCTCAGAAGCGTATGAGAAGATTCTGGATCGGAGCGGGGAAAAGCTCCAGACAGAAAATCTCCTTCAAATT GTCTTAGCTGCATCACGACCTCTATCACTTGACGAAGCCAACATAGCCTTAACGATGGCTTTGAGAAAGGGCACT TTTAGTTCTTACGACGATCTCCAGAAAGATTCTTGGCCGAGAGATAACTTCAAAGGCGTTGTGGAAAATCTTTGC GGTCTCTTCATCAATGTGTACGATTCTAAGTTGTTTTTTATCCATCAGACAGCCAGAGATTTTCTCATCAACCCT CCTCGGAGTGGAAAGTGGAAGGGGCGGCTGAGTATGCAACATTCACACGCGAACATGGCGCTGTTGTGTCTATCA TTCTTGTCGTTTCTAGATGGGCAATCATCAGTGGAGCAAATCGAGGCAAAGTTTCCGTTGGCGCGGTACTCGGCC CAGCATTGGATGGATCATGCACGGCCTGCGGAGACAGAGAACGAAGTCCAGAAAAGCGTCATGGAGTTTTTCCTT CAAGAAAATCAAGCTTGGGGTGAGCTCTTTGAGTCGATTTATTACCGGCGGTCATATGGACGACCCCACATCCTG GCAACTCCACTATACTACGCATCGTCCTTCGGTCTCCAACAAACAGCACAACTCCTATTGGCTAAAGGCGCGGAT GTCAACGCGCAGATTGACAATTATGGAAGTGCACTCCAGGCGGCTTCTGATAGAGGTTACATAGAGATTGTGGAG CTACTGTTAGCCCATGGCGCGGAAATCAACGCACAGGGTGGCATTTACGGAAATGCACTCGAGGCGGCTTCCTCT GGCGGCCATAAAGAGATCATGGGGCTACTATTAGCCAATGGCGCGGGGGTCAATACGCAGGGCTCTTATGGAAGC GCACTCCAGGCGGCTTCCGTTAGTGGTCATACAGAGATTGCGGAGCTGCTATTAGCCAATGGTGCGGAGACCAAT ACGCAGGGCGGCTTTTATGGGAGCGTACTCCAGGCGGCTTCCGTTAATGGTCATACAGAGATTGCGGAGCTGCTA TTAGCCAATGGTGCGGATATCAGGACGCAGGGTGGCTTATATGGAGGTGCACTCCAGGCGGCTTCCTCTAATGGT CATAAAGAGATGGTCGAGCTGCTATTAGCCAATGGCGCGGAGATCGATGTCAACGCTCAGGGCGGCTTAGATGGA AATGCACTCCAGGCGGCCTCCGCTAATGGTCATAAAGAGATTGTGGAGCTGCTATTAGCTCATGGCGCAGAGATT AATACACAGGGTGGCTTTTATGGAAGTGCACTCCAGGCGGCTTCTGCTTGCGGTCACAAAGAGGTCGTGGAGCTT CTATTAGCTAAGGGCGCGGAGATCAACGCGCAGGGAGGCTTATATGGAAGTTCATTCCAGGCGGCTTCCGCTTGC GGTCACAAAGAGGTTGTGGAGCTACTATTAGCCAAGGGCGCGGAGATCAACGCGTAG
Transcript	>Pro_DTO377G3_2|g5444.t1 ATGGAAGACCCAGACCGGAAAATGGGTAAAAGTACAAAGATGACCAACAAACTGGCGGCGAAGCTAGCGAAATGG AGAAAGAAGGAGAAACCCGATAGAACACGTGGAGGTGCCCTTGTCGTCTCTCCGACCGCAGAGTCAAACACGTCC GAGCCTTCTATGGTAAACTATGTACAGCCTTCAGATGGCCTTACTGGAAATCCCGACAAGCTCTCCAAACCTGCT TTGGTGACTTCCAATACCATGCCGGTCTCAAGTCTTTTCGAGCCCCTCTCGCTGGAAACGACCGACGTGCAGCCC GAAAATTTCATACCCGGTCCATCATCTTCTCCTACGACCGAAGACACCTGGGCCCGGGCATATAAACTCTTGCAG GCTCGAGAGCCCGAGTTGGTAAAAGATTATCAGACTCATTTGAGCCTAGCGCAACCCGAGAACTCAGAGCACATA AATCTCTCAAATCCACACTCAGTTGAGCGGGTGATAAAGCAGCTGCTGGAAGTTCGGGACCAGAAGCAGTGGCGA GTCTCACTAGTGGGAAAGGAGGTGAAGATACGAGAGCAAGCCGAAAAACTAGTTAAGTTTCTCCTCTGGGCCGAA CCAGCCGTGAAGAAAGCCGTTAGCACCCAGCCATATGCAGCATTGGCGTGGGCTGGCGTTTCGCTGCTCTTACCT CTTCTCACAAGCAGTACCACTAGCAATCTTGCGATGCTTGAAGGCTTCGATTCCATTGATCATGTTCAGATCTAC TGGGATATCTGCGAGAAGACATACTTGCAGTCCAAGGATGGGGAAGAGTATCAAGCTCTCATCCAACCCCTTGCT AAGGTCTACTCTTTTATACTCGAATACCAAGCACGTGCTATCTGTCATTTCTCAAAAGCTCAAGTCTCTCGCGCA TGGGAGAACATGACGGGTGAAAGCAATTGGGGAAAAATAAGATTAACAATCGAACAATTGAGCGATAACTGTAGG AGCTATGTCTCCCCCCTCAAACTTGGGGAGGTTCGCCGTCATCGAGATCGTCAATTACTGGAGATTAAAGAGTCT CGGGTTATTCTTGATGGCATTTTGGATGTCCTAAAAGCGGACACGAGTCGGAACCAGAAGAATTATAAAGACCAG AACGAGCGAGGGTTTCTTCAAGCACTTGCGTCCGACTACGAGGATGGCAAGAATTATAACCCACTGAGAATCCCA GGGACATGCGATTGGTTCTTACAGGGTGACGTACTTCGAAACTGGCGGGATAACGACCGCTCCAGTCTTCTGTGG ATTTCCGCTGGGCCTGGCTGTGGAAAGTCGGTGTTGTCACGGGCTCTCATTGACGAGAATCGGCTTTCTACGAAT ATTTCGACATCTACTGTCTGCTATTTCTTTTTCAAAGATGGGGATGAGCGCCGCGTGTCAGCCACTGATGCTTTG TGCGCATTGCTTCACCAACTTTTCACCCACGATTCGACGGGCACACTGATCCAAAATGCAATGCCCAGCCACAAA AATCACGGCCCAAATCTAGTACAGAACTTCTCTGAGCTGTGGCGTCTGTTCATCCAATGCGTCAGCTCGCCAGAG GTTGGAGAGATAGTTTGTGTCCTTGATGCCCTGGATGAATGCAATGATCATAGCAGTCGGCAATTGATCCGCAAA CTAAGGGAGCTTTACTCCGAGCCCCAAGTTTCATCTTTAACCTCGAAACTGAAGTTTCTGATCACTGGTCGCCCT TATGATCACCTGGAGGCATCGTTCCAAGATTTCCCTGATACAACAACTTGTGTGCGCTTGGACGGAGATGAAAAG ACCGCCGAAATCAGCAACGATATAGATCTGGTCATCGATGCTAGACTACAAAACCTCGCCCAAAACCTCCTAGAG AGCGACCGTCAAATGATTTCAGATCAACTCAAGAGCATGGAGAATCGTACTTACCTCTGGCTACATCTCACTTTC GATATTATTGAGCATAGCCGGAGTGAGTATGGTCGACTGTCCGATATGAAAGAACTATTCTCTGGGCTGCCTTCT AAGGTCTCAGAAGCGTATGAGAAGATTCTGGATCGGAGCGGGGAAAAGCTCCAGACAGAAAATCTCCTTCAAATT GTCTTAGCTGCATCACGACCTCTATCACTTGACGAAGCCAACATAGCCTTAACGATGGCTTTGAGAAAGGGCACT TTTAGTTCTTACGACGATCTCCAGAAAGATTCTTGGCCGAGAGATAACTTCAAAGGCGTTGTGGAAAATCTTTGC GGTCTCTTCATCAATGTGTACGATTCTAAGTTGTTTTTTATCCATCAGACAGCCAGAGATTTTCTCATCAACCCT CCTCGGAGTGGAAAGTGGAAGGGGCGGCTGAGTATGCAACATTCACACGCGAACATGGCGCTGTTGTGTCTATCA TTCTTGTCGTTTCTAGATGGGCAATCATCAGTGGAGCAAATCGAGGCAAAGTTTCCGTTGGCGCGGTACTCGGCC CAGCATTGGATGGATCATGCACGGCCTGCGGAGACAGAGAACGAAGTCCAGAAAAGCGTCATGGAGTTTTTCCTT CAAGAAAATCAAGCTTGGGGTGAGCTCTTTGAGTCGATTTATTACCGGCGGTCATATGGACGACCCCACATCCTG GCAACTCCACTATACTACGCATCGTCCTTCGGTCTCCAACAAACAGCACAACTCCTATTGGCTAAAGGCGCGGAT GTCAACGCGCAGATTGACAATTATGGAAGTGCACTCCAGGCGGCTTCTGATAGAGGTTACATAGAGATTGTGGAG CTACTGTTAGCCCATGGCGCGGAAATCAACGCACAGGGTGGCATTTACGGAAATGCACTCGAGGCGGCTTCCTCT GGCGGCCATAAAGAGATCATGGGGCTACTATTAGCCAATGGCGCGGGGGTCAATACGCAGGGCTCTTATGGAAGC GCACTCCAGGCGGCTTCCGTTAGTGGTCATACAGAGATTGCGGAGCTGCTATTAGCCAATGGTGCGGAGACCAAT ACGCAGGGCGGCTTTTATGGGAGCGTACTCCAGGCGGCTTCCGTTAATGGTCATACAGAGATTGCGGAGCTGCTA TTAGCCAATGGTGCGGATATCAGGACGCAGGGTGGCTTATATGGAGGTGCACTCCAGGCGGCTTCCTCTAATGGT CATAAAGAGATGGTCGAGCTGCTATTAGCCAATGGCGCGGAGATCGATGTCAACGCTCAGGGCGGCTTAGATGGA AATGCACTCCAGGCGGCCTCCGCTAATGGTCATAAAGAGATTGTGGAGCTGCTATTAGCTCATGGCGCAGAGATT AATACACAGGGTGGCTTTTATGGAAGTGCACTCCAGGCGGCTTCTGCTTGCGGTCACAAAGAGGTCGTGGAGCTT CTATTAGCTAAGGGCGCGGAGATCAACGCGCAGGGAGGCTTATATGGAAGTTCATTCCAGGCGGCTTCCGCTTGC GGTCACAAAGAGGTTGTGGAGCTACTATTAGCCAAGGGCGCGGAGATCAACGCGTAG
Gene	>Pro_DTO377G3_2|g5444.t1 ATGGAAGACCCAGACCGGAAAATGGGTAAAAGTACAAAGATGACCAACAAACTGGCGGCGAAGCTAGCGAAATGG AGAAAGAAGGAGAAACCCGATAGAACACGTGGAGGTGCCCTTGTCGTCTCTCCGACCGCAGAGTCAAACACGTCC GAGCCTTCTATGGTAAACTATGTACAGCCTTCAGATGGCCTTACTGGAAATCCCGACAAGCTCTCCAAACCTGCT TTGGTGACTTCCAATACCATGCCGGTCTCAAGTCTTTTCGAGCCCCTCTCGCTGGAAACGACCGACGTGCAGCCC GAAAATTTCATACCCGGTCCATCATCTTCTCCTACGACCGAAGACACCTGGGCCCGGGCATATAAACTCTTGCAG GCTCGAGAGCCCGAGTTGGTAAAAGATTATCAGACTCATTTGAGCCTAGCGCAACCCGAGAACTCAGAGCACATA AATCTCTCAAATCCACACTCAGTTGAGCGGGTGATAAAGCAGCTGCTGGAAGTTCGGGACCAGAAGCAGTGGCGA GTCTCACTAGTGGGAAAGGAGGTGAAGATACGAGAGCAAGCCGAAAAACTAGTTAAGTTTCTCCTCTGGGCCGAA CCAGCCGTGAAGAAAGCCGTTAGCACCCAGCCATATGCAGCATTGGCGTGGGCTGGCGTTTCGCTGCTCTTACCT GTAAGCCAAGCAATCCTCCTATTATCTAGCCAAGGCTGACCCAGACAGCTTCTCACAAGCAGTACCACTAGCAAT CTTGCGATGCTTGAAGGCTTCGATTCCATTGATCATGTTCAGATCTACTGGGATATCTGCGAGAAGACATACTTG CAGTCCAAGGATGGGGAAGAGTATCAAGCTCTCATCCAACCCCTTGCTAAGGTCTACTCTTTTATACTCGAATAC CAAGCACGTGCTATCTGTCATTTCTCAAAAGCTCAAGTCTCTCGCGCATGGGAGAACATGACGGGTGAAAGCAAT TGGGGAAAAATAAGATTAACAATCGAACAATTGAGCGATAACTGTAGGAGCTATGTCTCCCCCCTCAAACTTGGG GAGGTTCGCCGTCATCGAGATCGTCAATTACTGGAGATTAAAGAGTCTCGGGTTATTCTTGATGGCATTTTGGAT GTCCTAAAAGCGGACACGAGTCGGAACCAGAAGAATTATAAAGACCAGAACGAGCGAGGGTTTCTTCAAGCACTT GCGTCCGACTACGAGGATGGCAAGAATTATAACCCACTGAGAATCCCAGGGACATGCGATTGGTTCTTACAGGGT GACGTACTTCGAAACTGGCGGGATAACGACCGCTCCAGTCTTCTGTGGATTTCCGCTGGGCCTGGCTGTGGAAAG TCGGTGTTGTCACGGGCTCTCATTGACGAGAATCGGCTTTCTACGAATATTTCGACATCTACTGTCTGCTATTTC TTTTTCAAAGATGGGGATGAGCGCCGCGTGTCAGCCACTGATGCTTTGTGCGCATTGCTTCACCAACTTTTCACC CACGATTCGACGGGCACACTGATCCAAAATGCAATGCCCAGCCACAAAAATCACGGCCCAAATCTAGTACAGAAC TTCTCTGAGCTGTGGCGTCTGTTCATCCAATGCGTCAGCTCGCCAGAGGTTGGAGAGATAGTTTGTGTCCTTGAT GCCCTGGATGAATGCAATGATCATAGCAGTCGGCAATTGATCCGCAAACTAAGGGAGCTTTACTCCGAGCCCCAA GTTTCATCTTTAACCTCGAAACTGAAGTTTCTGATCACTGGTCGCCCTTATGATCACCTGGAGGCATCGTTCCAA GATTTCCCTGATACAACAACTTGTGTGCGCTTGGACGGAGATGAAAAGACCGCCGAAATCAGCAACGATATAGAT CTGGTCATCGATGCTAGACTACAAAACCTCGCCCAAAACCTCCTAGAGAGCGACCGTCAAATGATTTCAGATCAA CTCAAGAGCATGGAGAATCGTACTTACCTCTGGCTACATCTCACTTTCGATATTATTGAGCATAGCCGGAGTGAG TATGGTCGACTGTCCGATATGAAAGAACTATTCTCTGGGCTGCCTTCTAAGGTCTCAGAAGCGTATGAGAAGATT CTGGATCGGAGCGGGGAAAAGCTCCAGACAGAAAATCTCCTTCAAATTGTCTTAGCTGCATCACGACCTCTATCA CTTGACGAAGCCAACATAGCCTTAACGATGGCTTTGAGAAAGGGCACTTTTAGTTCTTACGACGATCTCCAGAAA GATTCTTGGCCGAGAGATAACTTCAAAGGCGTTGTGGAAAATCTTTGCGGTCTCTTCATCAATGTGTACGATTCT AAGTTGTTTTTTATCCATCAGACAGCCAGAGATTTTCTCATCAACCCTCCTCGGAGTGGAAAGTGGAAGGGGCGG CTGAGTATGCAACATTCACACGCGAACATGGCGCTGTTGTGTCTATCATTCTTGTCGTTTCTAGATGGGCAATCA TCAGTGGAGCAAATCGAGGCAAAGTTTCCGTTGGCGCGGTACTCGGCCCAGCATTGGATGGATCATGCACGGCCT GCGGAGACAGAGAACGAAGTCCAGAAAAGCGTCATGGAGTTTTTCCTTCAAGAAAATCAAGCTTGGGGTGAGCTC TTTGAGTCGATTTATTACCGGCGGTCATATGGACGACCCCACATCCTGGCAACTCCACTATACTACGCATCGTCC TTCGGTCTCCAACAAACAGCACAACTCCTATTGGCTAAAGGCGCGGATGTCAACGCGCAGATTGACAATTATGGA AGTGCACTCCAGGCGGCTTCTGATAGAGGTTACATAGAGATTGTGGAGCTACTGTTAGCCCATGGCGCGGAAATC AACGCACAGGGTGGCATTTACGGAAATGCACTCGAGGCGGCTTCCTCTGGCGGCCATAAAGAGATCATGGGGCTA CTATTAGCCAATGGCGCGGGGGTCAATACGCAGGGCTCTTATGGAAGCGCACTCCAGGCGGCTTCCGTTAGTGGT CATACAGAGATTGCGGAGCTGCTATTAGCCAATGGTGCGGAGACCAATACGCAGGGCGGCTTTTATGGGAGCGTA CTCCAGGCGGCTTCCGTTAATGGTCATACAGAGATTGCGGAGCTGCTATTAGCCAATGGTGCGGATATCAGGACG CAGGGTGGCTTATATGGAGGTGCACTCCAGGCGGCTTCCTCTAATGGTCATAAAGAGATGGTCGAGCTGCTATTA GCCAATGGCGCGGAGATCGATGTCAACGCTCAGGGCGGCTTAGATGGAAATGCACTCCAGGCGGCCTCCGCTAAT GGTCATAAAGAGATTGTGGAGCTGCTATTAGCTCATGGCGCAGAGATTAATACACAGGGTGGCTTTTATGGAAGT GCACTCCAGGCGGCTTCTGCTTGCGGTCACAAAGAGGTCGTGGAGCTTCTATTAGCTAAGGGCGCGGAGATCAAC GCGCAGGGAGGCTTATATGGAAGTTCATTCCAGGCGGCTTCCGCTTGCGGTCACAAAGAGGTTGTGGAGCTACTA TTAGCCAAGGGCGCGGAGATCAACGCGTAG