Fungal Genomics

Agaricus bisporus var bisporus H39 Agaricus bisporus var bisporus H97 Agaricus bisporus var burnettii H119p4 Aspergillus niger CBS 112.32 Aspergillus niger CBS 113.50 Aspergillus niger CBS 115988 Aspergillus niger CBS 115989 Aspergillus niger CBS 118.52 Aspergillus niger CBS 124.48 Aspergillus niger CBS 131.52 Aspergillus niger CBS 133816 Aspergillus niger CBS 147320 Aspergillus niger CBS 147321 Aspergillus niger CBS 147322 Aspergillus niger CBS 147323 Aspergillus niger CBS 147324 Aspergillus niger CBS 147343 Aspergillus niger CBS 147344 Aspergillus niger CBS 147345 Aspergillus niger CBS 147346 Aspergillus niger CBS 147347 Aspergillus niger CBS 147352 Aspergillus niger CBS 147353 Aspergillus niger CBS 147371 Aspergillus niger CBS 147482 Aspergillus niger CBS 630.78 Aspergillus niger CBS 769.97 Niveomyces coronatus CBS 149186 Ophiocordyceps australis 1348a (Ghana) Ophiocordyceps australis map64 (Brazil) Ophiocordyceps camponoti-floridani Ophiocordyceps camponoti-rufipedis Ophiocordyceps kimflemingae Ophiocordyceps subramaniannii Penicillium roqueforti DTO002I6 Penicillium roqueforti DTO003C3 Penicillium roqueforti DTO003H1 (CBS 147308) Penicillium roqueforti DTO006G1 Penicillium roqueforti DTO006G7 Penicillium roqueforti DTO012A1 Penicillium roqueforti DTO012A2 (CBS 147309) Penicillium roqueforti DTO012A6 (CBS 147310) Penicillium roqueforti DTO012A7 Penicillium roqueforti DTO012A8 Penicillium roqueforti DTO012A9 Penicillium roqueforti DTO013E5 Penicillium roqueforti DTO013F2 Penicillium roqueforti DTO013F5 (CBS 147311) Penicillium roqueforti DTO027I6 Penicillium roqueforti DTO032C6 Penicillium roqueforti DTO039G3 Penicillium roqueforti DTO046C5 Penicillium roqueforti DTO070G2 (CBS 147317) Penicillium roqueforti DTO081F9 (CBS 147318) Penicillium roqueforti DTO101D6 (CBS 147325) Penicillium roqueforti DTO102I9 (CBS 147326) Penicillium roqueforti DTO126G2 (CBS 147330) Penicillium roqueforti DTO127F7 (CBS 147331) Penicillium roqueforti DTO127F9 (CBS 147332) Penicillium roqueforti DTO130C1 (CBS 147333) Penicillium roqueforti DTO163C3 (CBS 147337) Penicillium roqueforti DTO163F5 (CBS 147338) Penicillium roqueforti DTO163G4 (CBS 147339) Penicillium roqueforti DTO265D5 (CBS 147372) Penicillium roqueforti DTO369A1 (CBS 147354) Penicillium roqueforti DTO375B1 (CBS 147355) Penicillium roqueforti DTO377G2 (LCP 96.3914a) Penicillium roqueforti LCP96 04111 Rhodonia placenta FPRL280 Torrubiellomyces zombiae CBS 149187

General Properties

Protein ID	Pro_DTO377G3_2|g542.t1
Gene name
Location	scaffold_01:1394581..1398614
Strand	+
Gene length (bp)	4033
Transcript length (bp)	3657
Coding sequence length (bp)	3657
Protein length (aa)	1219

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PFAM Domains

PFAM Domain ID	Short name	Long name	E-value	Start	End
PF00617	RasGEF	RasGEF domain	2.5E-58	968	1148
PF00618	RasGEF_N	RasGEF N-terminal motif	6.8E-30	800	901
PF00018	SH3_1	SH3 domain	1.5E-14	79	124
PF14604	SH3_9	Variant SH3 domain	2.5E-11	80	126
PF07653	SH3_2	Variant SH3 domain	8.7E-10	77	129

GO

GO Term	Description	Terminal node
GO:0005515	protein binding	Yes
GO:0005085	guanyl-nucleotide exchange factor activity	Yes
GO:0007264	small GTPase mediated signal transduction	Yes
GO:0030234	enzyme regulator activity	No
GO:0060589	nucleoside-triphosphatase regulator activity	No
GO:0008150	biological_process	No
GO:0098772	molecular function regulator activity	No
GO:0030695	GTPase regulator activity	No
GO:0050789	regulation of biological process	No
GO:0050794	regulation of cellular process	No
GO:0009987	cellular process	No
GO:0005488	binding	No
GO:0007165	signal transduction	No
GO:0035556	intracellular signal transduction	No
GO:0003674	molecular_function	No
GO:0065007	biological regulation	No

SignalP

[Help with interpreting these statistics]

SignalP signal predicted	Location (based on Ymax)	D score (significance: > 0.45)
No	1 - 18	0.45

Transmembrane Domains

(None)

Transcription Factor Class

(None)

Expression data

Analysis 1: Genome-wide gene expression in conidia of Penicillium roqueforti during growth at various temperatures and for various amounts of time. Published in Punt et al., 2020.

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Sequences

Type of sequence	Sequence
Locus	Download genbank file of locus The gene with 5 kb flanks (if sufficient flanking sequence is available). For use in cloning design programs. NOTE: features (genes or exons) that are only partially contained within the sequence are completely excluded.
Protein	>Pro_DTO377G3_2|g542.t1 MFGIRAADLAVDTTALAKSGSVATAFEYTDEQVTTPTALSRYRGRGNSVSRDFNHINHSPSKMASGYAVSPEPPA LFVRAMYDYDADDHTSLSFRRGDIIQVLNQLETGWWDGVIDDVRGWFPSNYCTPLTEADDFTNQFAHTHLETELG ADSGLEDEYGDGHDEDEVHSDDNARDPQPILPMEGVAAPKEQEEAAFWIPQATPDGRLFYFNTLTGYSTMELPFE NPTATIEPGPRDRNNFYVPDQTRPPPEMMARGFERDEDEYDGSASEAEGESLMLGSHGSISRRRQSVMDGISPAT SMDSLYAPGSKDFKMPHPPNKRPQKSYSLGGNSTSTSMTESYSRPSISYPPQHFVDDGFAPPITWPLLVDNMRHA VESYRQTLFKGERAEYVRKAEDISDHLRMLLAAGSDTTDNHSGNPSIISTNKALYPYFRDMMSKFSKLVLSSHIA AADWPGADSANKCLQEADGVMQGVYGYVEVAQQQRGDVIHRIVPGFVSGSSSGGSWQNNGVSLHTSGPTSFLVPD GDSRSEPSVSLDTAFLDSIDILRRSFVGSIRRLEERLVVNRKIVTAQEHADIADAISAAAIKVIEQFRPWISSVE SMNLAPLGTSFQNPQLVDFSLQKQRAYDAIGDFVLSCQAVSAPLADEWAELRGNSLDDRVNAVRGIARQLENYVS QIGFSLSLLLEQIPTEPVSSLRRGSRQESDDESFKKMHSRGESMAKIAESIGIPSSYAPEKEGGTDKVRRNMDKA QRFFGQAPPTAITREPIREPVREPEETPWFLKMAHEGEVFYDNKGDLPILKCGTLAGLVEHLTRHDKLDASFNNT FLLTYRSFTTATELFELLVQRFNVQPPFGLNQDDMQMWIDRKQKPIRFRVVNILKSWFDHFWMEPNDELHMDLLR RVHTFTSDSIATTKTPGTPTLLAVIEQRLRGQDTTVKRLVPTQSTAAPTPIIPKNMKKLKFLDIDPTEFARQLTI IESRLYSKIRPTECLNKTWQKKVGPDEPEPSPNVKALILHSNQLTNWVAEMILAQGDVKKRVVVIKHFVNVADKC RNLNNYSTLTSIISALGTAPIHRLGRTWGQVSGRTSAVLEQMRRLMASTKNFGEYRETLHLANPPCIPFFGVYLT DLTFIEDGIPSLTPSELINFNKRAKTAEVIRDIQQYQNVPYLLQPVGELQDYILSNLQGAGDVHDMYERSLEIEP REREDEKIARLLSESGFL*
Coding	>Pro_DTO377G3_2|g542.t1 ATGTTTGGGATTCGCGCGGCAGATTTAGCTGTCGACACTACTGCGCTGGCCAAATCCGGATCTGTTGCGACCGCA TTCGAGTACACCGACGAACAAGTGACCACGCCCACAGCCCTATCCCGCTATCGCGGTCGGGGAAACAGTGTATCA CGAGATTTCAACCACATCAACCATTCCCCGAGCAAAATGGCCTCTGGATATGCGGTCAGCCCGGAGCCCCCCGCG CTCTTCGTACGGGCCATGTACGACTATGATGCCGACGATCACACTAGCCTGAGTTTCCGCCGTGGCGACATTATT CAGGTCCTCAACCAGCTAGAAACCGGATGGTGGGATGGGGTAATCGATGATGTTCGAGGCTGGTTCCCAAGTAAC TATTGTACCCCACTCACGGAAGCGGACGATTTCACCAACCAGTTCGCACACACCCACCTTGAAACCGAGCTCGGC GCGGACTCTGGACTCGAAGATGAATATGGCGATGGACATGATGAGGATGAAGTGCACTCCGATGACAACGCTCGA GACCCACAGCCGATTCTTCCTATGGAGGGAGTCGCAGCGCCCAAGGAGCAGGAAGAGGCCGCATTCTGGATCCCC CAGGCGACACCGGACGGCCGTCTTTTCTACTTCAATACCCTCACCGGATATTCCACTATGGAGCTCCCTTTCGAA AACCCGACCGCAACAATCGAACCCGGCCCACGAGATCGAAATAATTTCTATGTCCCCGACCAGACACGGCCACCC CCGGAGATGATGGCCCGTGGTTTTGAGCGAGATGAAGACGAGTACGATGGCTCTGCATCGGAGGCCGAAGGAGAA TCATTGATGTTAGGCTCGCATGGCTCGATTTCTCGCCGACGCCAGTCCGTGATGGACGGGATATCCCCCGCCACG TCTATGGATTCGTTGTACGCCCCAGGATCTAAAGATTTCAAAATGCCGCACCCGCCGAACAAGCGCCCGCAAAAA TCATACAGCCTGGGCGGAAACAGTACCAGTACATCTATGACCGAAAGCTATTCGAGACCTTCTATTTCCTACCCT CCTCAGCATTTTGTCGACGATGGCTTCGCACCACCAATAACCTGGCCTTTGCTTGTGGATAATATGCGCCACGCC GTGGAATCTTATCGCCAAACGCTTTTCAAAGGTGAGCGTGCAGAGTATGTAAGAAAGGCCGAGGACATATCCGAC CATCTTCGCATGCTGCTTGCTGCTGGATCTGACACCACGGATAACCACTCTGGCAACCCATCTATCATTTCCACA AACAAGGCCCTATATCCTTATTTCCGGGATATGATGTCCAAATTCTCGAAGCTGGTTCTTTCATCACACATTGCT GCCGCTGATTGGCCTGGTGCCGACTCGGCCAATAAATGCTTGCAGGAGGCCGACGGAGTTATGCAGGGTGTGTAT GGCTACGTGGAAGTGGCACAACAACAGCGCGGAGATGTGATTCATCGCATTGTGCCTGGCTTCGTCAGTGGTAGC TCTTCCGGTGGTAGCTGGCAGAACAATGGTGTTTCTTTGCATACTTCAGGTCCAACATCATTCCTTGTCCCGGAT GGAGACTCGCGATCAGAGCCTTCGGTCTCTCTTGACACTGCGTTTTTGGATTCAATCGACATACTCAGGAGATCT TTTGTTGGTAGCATCCGGCGGCTAGAAGAGCGGCTGGTTGTAAACCGGAAGATCGTCACAGCGCAGGAACATGCA GATATTGCGGATGCAATCTCCGCTGCTGCAATCAAGGTCATTGAACAGTTTCGCCCATGGATCTCTTCTGTCGAG TCGATGAATTTAGCTCCGTTGGGGACCAGCTTCCAGAACCCCCAGCTAGTAGACTTTAGCTTGCAAAAGCAGAGA GCCTACGATGCTATTGGAGATTTCGTCCTGAGCTGTCAAGCAGTTTCCGCCCCTCTGGCCGATGAGTGGGCCGAG CTTCGTGGTAATTCTCTCGACGATCGTGTGAATGCCGTGCGAGGCATCGCCAGGCAGTTGGAGAACTATGTCTCC CAGATTGGTTTCTCGCTGTCGCTGCTCCTTGAGCAAATTCCCACCGAGCCAGTATCATCTCTACGACGTGGTAGC CGCCAGGAATCGGATGATGAGTCGTTCAAGAAGATGCATAGCCGTGGCGAGTCCATGGCCAAGATTGCAGAGTCA ATCGGAATTCCATCCTCCTACGCCCCTGAAAAAGAAGGTGGCACCGATAAAGTACGAAGAAATATGGACAAGGCC CAACGATTCTTTGGCCAGGCACCCCCAACAGCTATCACGCGAGAGCCAATCCGTGAGCCAGTCCGCGAGCCAGAA GAGACTCCCTGGTTCTTGAAAATGGCCCATGAAGGCGAAGTGTTCTACGATAACAAGGGAGACCTGCCAATCCTC AAATGTGGAACACTCGCGGGATTGGTTGAACACCTCACCCGCCACGATAAGCTTGATGCATCCTTCAACAACACC TTCCTCCTCACCTATCGCTCTTTCACGACTGCCACCGAACTATTTGAATTGCTTGTCCAGCGATTTAACGTTCAG CCTCCATTTGGCTTAAATCAAGATGACATGCAAATGTGGATTGATCGGAAACAGAAGCCGATCAGATTCCGTGTC GTCAACATTCTTAAGAGTTGGTTCGATCACTTCTGGATGGAGCCTAATGATGAACTGCACATGGACCTCCTGCGG CGTGTCCATACTTTTACCAGCGACTCAATCGCTACTACAAAAACGCCAGGAACCCCTACATTATTGGCCGTGATC GAACAACGACTTCGAGGACAAGACACAACCGTCAAGCGCCTTGTTCCAACTCAGAGCACCGCCGCACCAACACCA ATTATCCCTAAGAATATGAAGAAGTTGAAGTTCCTCGACATTGATCCGACGGAGTTTGCTCGGCAGTTGACCATC ATTGAGTCGCGCCTCTACTCCAAAATCCGGCCCACTGAGTGTTTGAACAAGACATGGCAGAAGAAGGTTGGCCCC GATGAGCCAGAACCATCTCCCAATGTCAAGGCCTTGATTCTTCACTCGAACCAGCTTACTAACTGGGTCGCTGAA ATGATTCTCGCTCAAGGCGATGTCAAGAAGCGTGTGGTGGTCATCAAACACTTTGTGAACGTGGCTGATAAATGT CGCAACCTGAACAATTATTCTACCCTGACATCCATCATTTCGGCTCTTGGAACTGCACCCATTCATCGTCTAGGT AGGACATGGGGCCAGGTTAGCGGACGCACGTCCGCTGTTTTGGAACAGATGCGTCGGCTTATGGCTAGTACGAAG AACTTTGGCGAATATCGAGAAACCCTACATCTCGCTAACCCGCCCTGTATTCCATTCTTCGGTGTCTATCTTACA GATTTGACCTTCATTGAAGACGGTATTCCGTCTCTAACACCATCAGAATTGATCAACTTCAATAAGCGGGCAAAG ACTGCAGAAGTCATTCGGGATATCCAGCAATACCAGAATGTGCCTTATCTTTTGCAACCCGTCGGCGAACTTCAA GATTACATTCTCAGTAACCTCCAAGGTGCTGGCGATGTACACGACATGTACGAACGAAGTCTGGAAATCGAGCCT AGGGAGCGCGAGGATGAAAAGATTGCAAGATTACTATCTGAGTCCGGCTTCCTGTAA
Transcript	>Pro_DTO377G3_2|g542.t1 ATGTTTGGGATTCGCGCGGCAGATTTAGCTGTCGACACTACTGCGCTGGCCAAATCCGGATCTGTTGCGACCGCA TTCGAGTACACCGACGAACAAGTGACCACGCCCACAGCCCTATCCCGCTATCGCGGTCGGGGAAACAGTGTATCA CGAGATTTCAACCACATCAACCATTCCCCGAGCAAAATGGCCTCTGGATATGCGGTCAGCCCGGAGCCCCCCGCG CTCTTCGTACGGGCCATGTACGACTATGATGCCGACGATCACACTAGCCTGAGTTTCCGCCGTGGCGACATTATT CAGGTCCTCAACCAGCTAGAAACCGGATGGTGGGATGGGGTAATCGATGATGTTCGAGGCTGGTTCCCAAGTAAC TATTGTACCCCACTCACGGAAGCGGACGATTTCACCAACCAGTTCGCACACACCCACCTTGAAACCGAGCTCGGC GCGGACTCTGGACTCGAAGATGAATATGGCGATGGACATGATGAGGATGAAGTGCACTCCGATGACAACGCTCGA GACCCACAGCCGATTCTTCCTATGGAGGGAGTCGCAGCGCCCAAGGAGCAGGAAGAGGCCGCATTCTGGATCCCC CAGGCGACACCGGACGGCCGTCTTTTCTACTTCAATACCCTCACCGGATATTCCACTATGGAGCTCCCTTTCGAA AACCCGACCGCAACAATCGAACCCGGCCCACGAGATCGAAATAATTTCTATGTCCCCGACCAGACACGGCCACCC CCGGAGATGATGGCCCGTGGTTTTGAGCGAGATGAAGACGAGTACGATGGCTCTGCATCGGAGGCCGAAGGAGAA TCATTGATGTTAGGCTCGCATGGCTCGATTTCTCGCCGACGCCAGTCCGTGATGGACGGGATATCCCCCGCCACG TCTATGGATTCGTTGTACGCCCCAGGATCTAAAGATTTCAAAATGCCGCACCCGCCGAACAAGCGCCCGCAAAAA TCATACAGCCTGGGCGGAAACAGTACCAGTACATCTATGACCGAAAGCTATTCGAGACCTTCTATTTCCTACCCT CCTCAGCATTTTGTCGACGATGGCTTCGCACCACCAATAACCTGGCCTTTGCTTGTGGATAATATGCGCCACGCC GTGGAATCTTATCGCCAAACGCTTTTCAAAGGTGAGCGTGCAGAGTATGTAAGAAAGGCCGAGGACATATCCGAC CATCTTCGCATGCTGCTTGCTGCTGGATCTGACACCACGGATAACCACTCTGGCAACCCATCTATCATTTCCACA AACAAGGCCCTATATCCTTATTTCCGGGATATGATGTCCAAATTCTCGAAGCTGGTTCTTTCATCACACATTGCT GCCGCTGATTGGCCTGGTGCCGACTCGGCCAATAAATGCTTGCAGGAGGCCGACGGAGTTATGCAGGGTGTGTAT GGCTACGTGGAAGTGGCACAACAACAGCGCGGAGATGTGATTCATCGCATTGTGCCTGGCTTCGTCAGTGGTAGC TCTTCCGGTGGTAGCTGGCAGAACAATGGTGTTTCTTTGCATACTTCAGGTCCAACATCATTCCTTGTCCCGGAT GGAGACTCGCGATCAGAGCCTTCGGTCTCTCTTGACACTGCGTTTTTGGATTCAATCGACATACTCAGGAGATCT TTTGTTGGTAGCATCCGGCGGCTAGAAGAGCGGCTGGTTGTAAACCGGAAGATCGTCACAGCGCAGGAACATGCA GATATTGCGGATGCAATCTCCGCTGCTGCAATCAAGGTCATTGAACAGTTTCGCCCATGGATCTCTTCTGTCGAG TCGATGAATTTAGCTCCGTTGGGGACCAGCTTCCAGAACCCCCAGCTAGTAGACTTTAGCTTGCAAAAGCAGAGA GCCTACGATGCTATTGGAGATTTCGTCCTGAGCTGTCAAGCAGTTTCCGCCCCTCTGGCCGATGAGTGGGCCGAG CTTCGTGGTAATTCTCTCGACGATCGTGTGAATGCCGTGCGAGGCATCGCCAGGCAGTTGGAGAACTATGTCTCC CAGATTGGTTTCTCGCTGTCGCTGCTCCTTGAGCAAATTCCCACCGAGCCAGTATCATCTCTACGACGTGGTAGC CGCCAGGAATCGGATGATGAGTCGTTCAAGAAGATGCATAGCCGTGGCGAGTCCATGGCCAAGATTGCAGAGTCA ATCGGAATTCCATCCTCCTACGCCCCTGAAAAAGAAGGTGGCACCGATAAAGTACGAAGAAATATGGACAAGGCC CAACGATTCTTTGGCCAGGCACCCCCAACAGCTATCACGCGAGAGCCAATCCGTGAGCCAGTCCGCGAGCCAGAA GAGACTCCCTGGTTCTTGAAAATGGCCCATGAAGGCGAAGTGTTCTACGATAACAAGGGAGACCTGCCAATCCTC AAATGTGGAACACTCGCGGGATTGGTTGAACACCTCACCCGCCACGATAAGCTTGATGCATCCTTCAACAACACC TTCCTCCTCACCTATCGCTCTTTCACGACTGCCACCGAACTATTTGAATTGCTTGTCCAGCGATTTAACGTTCAG CCTCCATTTGGCTTAAATCAAGATGACATGCAAATGTGGATTGATCGGAAACAGAAGCCGATCAGATTCCGTGTC GTCAACATTCTTAAGAGTTGGTTCGATCACTTCTGGATGGAGCCTAATGATGAACTGCACATGGACCTCCTGCGG CGTGTCCATACTTTTACCAGCGACTCAATCGCTACTACAAAAACGCCAGGAACCCCTACATTATTGGCCGTGATC GAACAACGACTTCGAGGACAAGACACAACCGTCAAGCGCCTTGTTCCAACTCAGAGCACCGCCGCACCAACACCA ATTATCCCTAAGAATATGAAGAAGTTGAAGTTCCTCGACATTGATCCGACGGAGTTTGCTCGGCAGTTGACCATC ATTGAGTCGCGCCTCTACTCCAAAATCCGGCCCACTGAGTGTTTGAACAAGACATGGCAGAAGAAGGTTGGCCCC GATGAGCCAGAACCATCTCCCAATGTCAAGGCCTTGATTCTTCACTCGAACCAGCTTACTAACTGGGTCGCTGAA ATGATTCTCGCTCAAGGCGATGTCAAGAAGCGTGTGGTGGTCATCAAACACTTTGTGAACGTGGCTGATAAATGT CGCAACCTGAACAATTATTCTACCCTGACATCCATCATTTCGGCTCTTGGAACTGCACCCATTCATCGTCTAGGT AGGACATGGGGCCAGGTTAGCGGACGCACGTCCGCTGTTTTGGAACAGATGCGTCGGCTTATGGCTAGTACGAAG AACTTTGGCGAATATCGAGAAACCCTACATCTCGCTAACCCGCCCTGTATTCCATTCTTCGGTGTCTATCTTACA GATTTGACCTTCATTGAAGACGGTATTCCGTCTCTAACACCATCAGAATTGATCAACTTCAATAAGCGGGCAAAG ACTGCAGAAGTCATTCGGGATATCCAGCAATACCAGAATGTGCCTTATCTTTTGCAACCCGTCGGCGAACTTCAA GATTACATTCTCAGTAACCTCCAAGGTGCTGGCGATGTACACGACATGTACGAACGAAGTCTGGAAATCGAGCCT AGGGAGCGCGAGGATGAAAAGATTGCAAGATTACTATCTGAGTCCGGCTTCCTGTAA
Gene	>Pro_DTO377G3_2|g542.t1 ATGTTTGGGATTCGCGCGGCAGATTTAGCTGTCGACACTACTGCGCTGGCCAAATCCGGATCTGTTGCGACCGCA TTCGAGTACACCGACGAACAAGTGACCACGCCCACAGCCCTATCCCGCTATCGCGGTCGGGGAAACAGTGTATCA CGAGATTTCAACCACATCAACCATTCCCCGAGCAAAATGGCCTCTGGATATGCGGTCAGCCCGGAGCCCCCCGCG CTCTTCGTACGGGCCATGTACGACTATGATGCCGACGATCACACTAGCCTGAGTTTCCGCCGTGGCGACATTATT CAGGTCCTCAACCAGCTAGAAACCGGATGGTGGGATGGGGTAATCGATGATGTTCGAGGCTGGTTCCCAAGTAAC TATTGTACCCCACTCACGGAAGCGGACGATTTCACCAACCAGTTCGCACACACCCACCTTGAAACCGAGCTCGGC GCGGACTCTGGACTCGAAGATGAATATGGCGATGGACATGATGAGGATGAAGTGCACTCCGATGACAACGCTCGA GACCCACAGCCGATTCTTCCTATGGAGGGAGTCGCAGCGCCCAAGGAGCAGGAAGAGGCCGCATTCTGGATCCCC CAGGCGACACCGGACGGCCGTCTTTTCTACTTCAATACCCTCACCGGATATTCCACTATGGAGCTCCCTTTCGAA AACCCGACCGCAACAATCGAACCCGGCCCACGAGATCGAAATAATTTCTATGTCCCCGACCAGACACGGCCACCC CCGGAGATGATGGCCCGTGGTTTTGAGCGAGATGAAGACGAGTACGATGGCTCTGCATCGGAGGCCGAAGGAGAA TCATTGATGTTAGGCTCGCATGGCTCGATTTCTCGCCGACGCCAGTCCGTGATGGACGGGATATCCCCCGCCACG TCTATGGATTCGTTGTACGCCCCAGGATCTAAAGATTTCAAAATGCCGCACCCGCCGAACAAGCGCCCGCAAAAA TCATACAGCCTGGGCGGAAACAGTACCAGTACATCTATGACCGAAAGCTATTCGAGACCTTCTATTTCCTACCCT CCTCAGCATTTTGTCGACGATGGCTTCGCACCACCAATAACCTGGCCTTTGCTTGTGGATAATATGCGCCACGCC GTGGAATCTTATCGCCAAACGCTTTTCAAAGGTGAGCGTGCAGAGTATGTAAGAAAGGCCGAGGACATATCCGAC CATCTTCGCATGCTGCTTGCTGCTGGATCTGACACCACGGATAACCACTCTGGCAACCCATCTATCATTTCCACA AACAAGGCCCTATATCCTTATTTCCGGGATATGATGTCCAAATTCTCGAAGCTGGTTCTTTCATCACACATTGCT GCCGCTGATTGGCCTGGTGCCGACTCGGCCAATAAATGCTTGCAGGAGGCCGACGGAGTTATGCAGGGTGTGTAT GGCTACGTGGAAGTGGCACAACAACAGCGCGGAGATGTGATTCATCGCATTGTGCCTGGCTTCGTCAGTGGTAGC TCTTCCGGTGGTAGCTGGCAGAACAATGGTGTTTCTTTGCATACTTCAGGTCCAACATCATTCCTTGTCCCGGAT GGAGACTCGCGATCAGAGCCTTCGGTCTCTCTTGACACTGCGTTTTTGGATTCAATCGACATACTCAGGAGATCT TTTGTTGGTAGCATCCGGCGGCTAGAAGAGCGGCTGGTTGTAAACCGGAAGATCGTCACAGCGCAGGAACATGCA GATATTGCGGATGCAATCTCCGCTGCTGCAATCAAGGTCATTGAACAGTTTCGCCCATGGATCTCTTCTGTCGAG TCGATGAATTTAGCTCCGTTGGGGACCAGCTTCCAGAACCCCCAGCTAGTAGACTTTAGCTTGCAAAAGCAGAGA GCCTACGATGCTATTGGAGATTTCGTCCTGAGCTGTCAAGCAGTTTCCGCCCCTCTGGCCGATGAGTGGGCCGAG CTTCGTGGTAATTCTCTCGACGATCGTGTGAATGCCGTGCGAGGCATCGCCAGGCAGTTGGAGAACTATGTCTCC CAGATTGGTTTCTCGCTGTCGCTGCTCCTTGAGCAAATTCCCACCGAGCCAGTATCATCTCTACGACGTGGTAGC CGCCAGGAATCGGATGATGAGTCGTTCAAGAAGATGCATAGCCGTGGCGAGTCCATGGCCAAGATTGCAGAGTCA ATCGGAATTCCATCCTCCTACGCCCCTGAAAAAGAAGGTGGCACCGATAAAGTACGAAGAAATATGGACAAGGCC CAACGATTCTTTGGCCAGGCACCCCCAACAGCTATCACGCGAGAGCCAATCCGTGAGCCAGTCCGCGAGCCAGAA GAGACTCCCTGGTTCTTGAAAATGGCCCATGAAGGCGAAGTGTTCTACGATAACAAGGGAGACCTGCCAATCCTC AAATGTGGAACACTCGCGGGATTGGTTGAACACCTCACCCGCCACGATAAGCTTGATGCATCCTTCAACAACACC TTCCTCCTCACCTATCGCTCTTTCACGACTGCCACCGAACTATTTGAATTGCTTGTCCAGCGATTTAACGTTCAG CCTCCATTTGGCTTAAATCAAGATGACATGCAAATGTGGATTGATCGGAAACAGAAGCCGATCAGATTCCGTGTC GTCAACATTCTTAAGAGTTGGTTCGATCACTTCTGGATGGAGCCTAATGATGAACTGCACATGGACCTCCTGCGG CGTGTCCATACTTTTACCAGCGACTCAATCGCTACTACAAAAACGCCAGGAACCCCTACATTATTGGCCGTGATC GAACAACGACTTCGAGGACAAGACACAACCGTCAAGCGCCTTGTTCCAACTCAGAGCACCGCCGCACCAACACCA ATTATCCCTAAGAATATGAAGAAGTTGAAGTTCCTCGACATTGATCCGACGGAGTTTGCTCGGCAGTTGACCATC ATTGAGTCGCGCCTCTACTCCAAAATCCGGCCCACTGAGTGTTTGAACAAGACATGGCAGAAGAAGGTTGGCCCC GATGAGCCAGAACCATCTCCCAATGTCAAGGCCTTGATTCTTCACTCGAACCAGCTTACTAACTGGGTCGCTGAA ATGATTCTCGCTCAAGGCGATGTCAAGAAGCGTGTGGTGGTCATCAAACACTTTGTGAACGTGGCTGATGTATGT ATTTTCTATATCTATTTGATATTGACCTTACTAACTCGACTATACAGAAATGTCGCAACCTGAACAATTATTCTA CCCTGACATCCATCATTTCGGCTCTTGGAACTGCACCCATTCATCGTCTAGGTAGGACATGGGGCCAGGTTAGCG GACGCACGTCCGCTGTTTTGGAACAGATGCGTCGGCTTATGGCTAGTACGAAGAACTTTGGCGAATATCGAGAAA CCCTACATCTCGCTAACCCGCCCTGTATTCCATTCTTCGGTATGCATCACAACCATTTCAAGCAGAATGTCTTGG AGCATCTCACCCCTTTGATTTGACTAACACATCGTAGGTGTCTATCTTACAGATTTGACCTTCATTGAAGACGGT ATTCCGTCTCTAACACCATCAGAATTGATCAACTTCAATAAGCGGGCAAAGACTGCAGAAGTCATTCGGGATATC CAGCAATACCAGAATGTGCCTTATCTTTTGCAACCCGTCGGCGAACTTCAAGATTACATTCTCAGTAACCTCCAA GGTGCTGGCGATGTACACGACATGTACGAACGAAGTCTGGAAATCGAGCCTAGGGAGCGCGAGGATGAAAAGATT GCAAGGTATGCTGAAGCCTCAAGCAGAGACAAGAGCTCCTTGTTGTTTGCATCCACCGTTGCTGTTTTGCGATAA TCTTGTTTTTTTCTTTTTCTTAAAAACTGGCGTTTGGCATTTGCCCGGCGATACCCAAATTTGACCTATTCTCTT TTTTTTGGGGGCCAAGACAACGACAACTCTGCTTTCTTTTTTTTTTCTTTCTCTCAAAACTGTTCGGCTGTTGAG ACTAACCGTTTTGGATTCTGAATCTCGTAGATTACTATCTGAGTCCGGCTTCCTGTAA