Fungal Genomics

Agaricus bisporus var bisporus H39 Agaricus bisporus var bisporus H97 Agaricus bisporus var burnettii H119p4 Aspergillus niger CBS 112.32 Aspergillus niger CBS 113.50 Aspergillus niger CBS 115988 Aspergillus niger CBS 115989 Aspergillus niger CBS 118.52 Aspergillus niger CBS 124.48 Aspergillus niger CBS 131.52 Aspergillus niger CBS 133816 Aspergillus niger CBS 147320 Aspergillus niger CBS 147321 Aspergillus niger CBS 147322 Aspergillus niger CBS 147323 Aspergillus niger CBS 147324 Aspergillus niger CBS 147343 Aspergillus niger CBS 147344 Aspergillus niger CBS 147345 Aspergillus niger CBS 147346 Aspergillus niger CBS 147347 Aspergillus niger CBS 147352 Aspergillus niger CBS 147353 Aspergillus niger CBS 147371 Aspergillus niger CBS 147482 Aspergillus niger CBS 630.78 Aspergillus niger CBS 769.97 Niveomyces coronatus CBS 149186 Ophiocordyceps australis 1348a (Ghana) Ophiocordyceps australis map64 (Brazil) Ophiocordyceps camponoti-floridani Ophiocordyceps camponoti-rufipedis Ophiocordyceps kimflemingae Ophiocordyceps subramaniannii Penicillium roqueforti DTO002I6 Penicillium roqueforti DTO003C3 Penicillium roqueforti DTO003H1 (CBS 147308) Penicillium roqueforti DTO006G1 Penicillium roqueforti DTO006G7 Penicillium roqueforti DTO012A1 Penicillium roqueforti DTO012A2 (CBS 147309) Penicillium roqueforti DTO012A6 (CBS 147310) Penicillium roqueforti DTO012A7 Penicillium roqueforti DTO012A8 Penicillium roqueforti DTO012A9 Penicillium roqueforti DTO013E5 Penicillium roqueforti DTO013F2 Penicillium roqueforti DTO013F5 (CBS 147311) Penicillium roqueforti DTO027I6 Penicillium roqueforti DTO032C6 Penicillium roqueforti DTO039G3 Penicillium roqueforti DTO046C5 Penicillium roqueforti DTO070G2 (CBS 147317) Penicillium roqueforti DTO081F9 (CBS 147318) Penicillium roqueforti DTO101D6 (CBS 147325) Penicillium roqueforti DTO102I9 (CBS 147326) Penicillium roqueforti DTO126G2 (CBS 147330) Penicillium roqueforti DTO127F7 (CBS 147331) Penicillium roqueforti DTO127F9 (CBS 147332) Penicillium roqueforti DTO130C1 (CBS 147333) Penicillium roqueforti DTO163C3 (CBS 147337) Penicillium roqueforti DTO163F5 (CBS 147338) Penicillium roqueforti DTO163G4 (CBS 147339) Penicillium roqueforti DTO265D5 (CBS 147372) Penicillium roqueforti DTO369A1 (CBS 147354) Penicillium roqueforti DTO375B1 (CBS 147355) Penicillium roqueforti DTO377G2 (LCP 96.3914a) Penicillium roqueforti LCP96 04111 Rhodonia placenta FPRL280 Torrubiellomyces zombiae CBS 149187

General Properties

Protein ID	Pro_DTO377G3_2|g4107.t1
Gene name
Location	scaffold_08:17824..20711
Strand	-
Gene length (bp)	2887
Transcript length (bp)	2823
Coding sequence length (bp)	2823
Protein length (aa)	941

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PFAM Domains

PFAM Domain ID	Short name	Long name	E-value	Start	End
PF02194	PXA	PXA domain	2.6E-34	157	333
PF08628	Nexin_C	Sorting nexin C terminal	3.0E-22	804	920

GO

(None)

SignalP

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SignalP signal predicted	Location (based on Ymax)	D score (significance: > 0.45)
No	1 - 31	0.5

Transmembrane Domains

Domain #	Start	End	Length
1	53	75	22

Transcription Factor Class

(None)

Expression data

Analysis 1: Genome-wide gene expression in conidia of Penicillium roqueforti during growth at various temperatures and for various amounts of time. Published in Punt et al., 2020.

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Sequences

Type of sequence	Sequence
Locus	Download genbank file of locus The gene with 5 kb flanks (if sufficient flanking sequence is available). For use in cloning design programs. NOTE: features (genes or exons) that are only partially contained within the sequence are completely excluded.
Protein	>Pro_DTO377G3_2|g4107.t1 MSRLSDDDSEVISAPSDKDHNTPTTKDPILNTAISKELINAILNFLSTSTNETLLGVFALLALVTYIVLGRIGLL LIGVAVGVVLHASWEGSDNEHGEEASHVQKPNRRRELALEVSNRLLDWPRRAGASDIQGDDGSINTLEDMSSADL EYATFQPATAVALRTLTDAVIQDYVKYWYEPLLPSEPSFPDSCRRILTHFITSVSSHLSRKRTEDTFLQFLTNSS SIVIVFLNELAAAFTAASSSPTEAQKTVDQYLEQFPDSSLANVLSAEQQKKKLSMIADDILSNFLDAKTYNYPAV RDFLREVFAGVILGSTVTSLARPEFINEWIIYLLQGGESEIMHAIDAGVEGARNQGVSAPRSSEHPKADSVKATQ RDSMHVARATEEEAVLEVKRLSAMIVSHDTQNSESERTRQNEQFDENYPLNTDLASDTTDENENHEDQGPIPNTQ SLASPKSFEDSSVPPLILHGAQVLVDDDGARDEKGQIKSRPVWDYLLQVEPASTRSTGWMVFRKYSDFQSLHEIL GTVSRLNQISSFSERHPILPTWKGKTRLALARDLGWYLQDAMKHESLADTDRMRRFLQKDAGASTQPSCNNKPGF SFPSQIAFEHMGKGMLGALTNAPRGVAGGGKAVFEGMTGVFGGTANGKKPAVGADQIQPKVDDSSRAIRSQTRFS FADRTDVSNENVDSPMVFPSDPLEIQGGEISKSSSVGSTRESFESERGAWTTEISPSKTSLDISDHTAELDVRAT ETIDQTSSHRRSDTGQSIDKPRNQGNPITADETKIAVELIFAVINELYTLSSAWNIRRTLLNAAKSYILRPGSPT LETIRTLLQDSMIEGHTSDDALGYYLVKLRENALPTEEELKAWPSPPSEEEKIRLRDTARKLFVQRGIPQALTSV MGAAASREALEKIFDSLQVESVARGFVFSILLQGLRVLTL*
Coding	>Pro_DTO377G3_2|g4107.t1 ATGAGTCGCCTCAGTGATGACGACTCCGAAGTCATTTCAGCTCCATCCGACAAAGACCACAATACTCCCACGACG AAAGATCCCATCTTAAATACAGCGATCTCAAAGGAACTCATCAATGCTATCCTCAATTTTCTCTCAACCTCTACC AATGAGACCCTCCTTGGAGTCTTTGCGCTTCTTGCACTCGTCACCTATATTGTCCTGGGGAGAATCGGTCTACTT CTGATTGGAGTGGCTGTGGGGGTTGTCCTACACGCGTCCTGGGAGGGATCAGATAACGAACACGGAGAAGAAGCG TCCCACGTGCAAAAGCCCAACCGGCGTAGAGAACTTGCCCTGGAAGTCTCCAACAGACTTTTAGACTGGCCGAGG CGGGCTGGTGCTTCAGACATCCAGGGGGACGATGGTTCTATAAACACGCTGGAAGATATGTCTTCGGCAGACTTG GAGTATGCCACCTTCCAACCGGCCACCGCTGTCGCGCTGAGAACGCTCACCGATGCTGTCATTCAAGATTATGTC AAATACTGGTATGAGCCACTTTTACCGTCCGAGCCAAGTTTTCCAGACTCCTGTCGAAGGATTTTGACTCATTTC ATTACTTCAGTTTCTTCGCACCTCTCGCGGAAACGAACAGAGGACACGTTCTTGCAGTTTCTCACCAACTCCTCA TCTATCGTCATTGTATTCTTGAATGAACTTGCAGCAGCATTCACTGCTGCGAGCTCATCCCCGACGGAAGCCCAA AAAACCGTGGACCAATACCTTGAACAATTCCCGGATAGCAGCCTAGCGAATGTCTTGTCTGCGGAACAACAAAAG AAAAAACTCAGCATGATCGCGGATGACATACTGTCGAATTTCTTGGATGCCAAAACCTACAATTATCCGGCTGTA CGGGACTTCCTCCGTGAGGTCTTTGCGGGCGTGATATTGGGGTCAACTGTTACCAGTCTTGCCCGTCCTGAATTT ATCAATGAATGGATTATCTATCTTCTTCAGGGCGGTGAATCCGAAATTATGCACGCTATCGACGCAGGCGTTGAG GGTGCACGGAACCAGGGTGTCAGTGCTCCTAGGTCTTCAGAACACCCAAAGGCAGACTCCGTCAAAGCCACACAG AGAGATTCCATGCATGTAGCGAGGGCTACAGAGGAAGAGGCGGTTCTAGAGGTGAAACGTCTGAGTGCTATGATT GTATCCCACGATACACAGAACTCGGAGTCAGAACGGACGCGCCAAAACGAACAATTTGACGAAAATTACCCTTTG AACACTGATTTGGCTTCAGACACGACTGATGAGAACGAAAACCACGAAGACCAGGGGCCGATACCTAATACGCAA TCACTTGCAAGCCCGAAATCATTCGAAGACTCTTCTGTGCCACCTTTGATTCTTCATGGGGCACAAGTGTTGGTA GATGATGATGGAGCAAGGGATGAAAAAGGCCAAATCAAGTCGCGACCCGTGTGGGATTATCTGCTACAGGTCGAA CCAGCGTCAACACGCTCGACTGGATGGATGGTGTTTCGCAAATATTCGGACTTCCAATCTCTTCACGAGATACTG GGGACCGTTTCACGATTGAATCAGATTTCGAGTTTCTCGGAGCGTCACCCCATACTGCCCACTTGGAAGGGCAAA ACACGACTAGCTCTCGCTCGGGACCTTGGGTGGTATTTACAAGATGCCATGAAGCACGAGTCACTTGCCGACACT GATCGAATGCGGCGATTTTTGCAAAAAGACGCTGGTGCTTCCACTCAACCTAGCTGTAACAACAAACCGGGATTC TCTTTCCCTAGTCAAATTGCGTTTGAACACATGGGCAAGGGTATGCTGGGTGCATTGACCAATGCGCCCAGGGGA GTGGCAGGGGGCGGTAAAGCCGTCTTTGAAGGAATGACAGGGGTGTTTGGCGGCACCGCCAATGGCAAGAAACCG GCTGTCGGTGCTGATCAGATTCAACCCAAAGTTGATGACTCCAGTCGCGCCATCCGGTCGCAGACACGGTTTAGC TTTGCTGATCGTACCGACGTAAGCAACGAAAACGTTGATTCGCCTATGGTGTTCCCTAGCGACCCCCTGGAAATC CAAGGAGGCGAAATTTCCAAGTCGTCTTCGGTTGGCAGTACCAGAGAGTCGTTTGAGAGTGAACGGGGTGCATGG ACCACAGAGATCTCACCCTCTAAAACCTCACTTGATATCAGCGATCATACTGCAGAACTTGATGTCCGGGCAACG GAAACTATTGATCAAACCTCATCACATCGCCGATCAGATACTGGGCAGAGTATTGATAAACCCCGCAATCAGGGG AATCCCATCACAGCTGATGAGACGAAAATAGCAGTAGAGCTGATCTTTGCGGTCATCAATGAGTTGTACACCTTG TCGTCTGCGTGGAACATACGCCGGACCCTTCTGAATGCTGCCAAATCGTATATTCTACGTCCCGGCAGCCCGACA TTGGAAACTATTCGTACGCTGTTGCAAGATTCCATGATAGAAGGCCACACTTCGGACGACGCCCTGGGGTATTAC CTCGTCAAGCTTCGTGAGAACGCGCTTCCGACAGAGGAGGAACTTAAAGCCTGGCCCTCTCCACCCAGTGAGGAG GAGAAGATCCGATTACGGGATACTGCACGTAAACTATTTGTGCAGCGGGGAATTCCACAGGCCTTAACAAGTGTT ATGGGGGCAGCTGCTAGTCGAGAAGCGCTAGAGAAGATCTTTGATAGTCTTCAAGTTGAGAGTGTCGCTCGAGGA TTTGTCTTCTCGATTTTACTACAGGGCCTTAGAGTATTGACTCTTTAA
Transcript	>Pro_DTO377G3_2|g4107.t1 ATGAGTCGCCTCAGTGATGACGACTCCGAAGTCATTTCAGCTCCATCCGACAAAGACCACAATACTCCCACGACG AAAGATCCCATCTTAAATACAGCGATCTCAAAGGAACTCATCAATGCTATCCTCAATTTTCTCTCAACCTCTACC AATGAGACCCTCCTTGGAGTCTTTGCGCTTCTTGCACTCGTCACCTATATTGTCCTGGGGAGAATCGGTCTACTT CTGATTGGAGTGGCTGTGGGGGTTGTCCTACACGCGTCCTGGGAGGGATCAGATAACGAACACGGAGAAGAAGCG TCCCACGTGCAAAAGCCCAACCGGCGTAGAGAACTTGCCCTGGAAGTCTCCAACAGACTTTTAGACTGGCCGAGG CGGGCTGGTGCTTCAGACATCCAGGGGGACGATGGTTCTATAAACACGCTGGAAGATATGTCTTCGGCAGACTTG GAGTATGCCACCTTCCAACCGGCCACCGCTGTCGCGCTGAGAACGCTCACCGATGCTGTCATTCAAGATTATGTC AAATACTGGTATGAGCCACTTTTACCGTCCGAGCCAAGTTTTCCAGACTCCTGTCGAAGGATTTTGACTCATTTC ATTACTTCAGTTTCTTCGCACCTCTCGCGGAAACGAACAGAGGACACGTTCTTGCAGTTTCTCACCAACTCCTCA TCTATCGTCATTGTATTCTTGAATGAACTTGCAGCAGCATTCACTGCTGCGAGCTCATCCCCGACGGAAGCCCAA AAAACCGTGGACCAATACCTTGAACAATTCCCGGATAGCAGCCTAGCGAATGTCTTGTCTGCGGAACAACAAAAG AAAAAACTCAGCATGATCGCGGATGACATACTGTCGAATTTCTTGGATGCCAAAACCTACAATTATCCGGCTGTA CGGGACTTCCTCCGTGAGGTCTTTGCGGGCGTGATATTGGGGTCAACTGTTACCAGTCTTGCCCGTCCTGAATTT ATCAATGAATGGATTATCTATCTTCTTCAGGGCGGTGAATCCGAAATTATGCACGCTATCGACGCAGGCGTTGAG GGTGCACGGAACCAGGGTGTCAGTGCTCCTAGGTCTTCAGAACACCCAAAGGCAGACTCCGTCAAAGCCACACAG AGAGATTCCATGCATGTAGCGAGGGCTACAGAGGAAGAGGCGGTTCTAGAGGTGAAACGTCTGAGTGCTATGATT GTATCCCACGATACACAGAACTCGGAGTCAGAACGGACGCGCCAAAACGAACAATTTGACGAAAATTACCCTTTG AACACTGATTTGGCTTCAGACACGACTGATGAGAACGAAAACCACGAAGACCAGGGGCCGATACCTAATACGCAA TCACTTGCAAGCCCGAAATCATTCGAAGACTCTTCTGTGCCACCTTTGATTCTTCATGGGGCACAAGTGTTGGTA GATGATGATGGAGCAAGGGATGAAAAAGGCCAAATCAAGTCGCGACCCGTGTGGGATTATCTGCTACAGGTCGAA CCAGCGTCAACACGCTCGACTGGATGGATGGTGTTTCGCAAATATTCGGACTTCCAATCTCTTCACGAGATACTG GGGACCGTTTCACGATTGAATCAGATTTCGAGTTTCTCGGAGCGTCACCCCATACTGCCCACTTGGAAGGGCAAA ACACGACTAGCTCTCGCTCGGGACCTTGGGTGGTATTTACAAGATGCCATGAAGCACGAGTCACTTGCCGACACT GATCGAATGCGGCGATTTTTGCAAAAAGACGCTGGTGCTTCCACTCAACCTAGCTGTAACAACAAACCGGGATTC TCTTTCCCTAGTCAAATTGCGTTTGAACACATGGGCAAGGGTATGCTGGGTGCATTGACCAATGCGCCCAGGGGA GTGGCAGGGGGCGGTAAAGCCGTCTTTGAAGGAATGACAGGGGTGTTTGGCGGCACCGCCAATGGCAAGAAACCG GCTGTCGGTGCTGATCAGATTCAACCCAAAGTTGATGACTCCAGTCGCGCCATCCGGTCGCAGACACGGTTTAGC TTTGCTGATCGTACCGACGTAAGCAACGAAAACGTTGATTCGCCTATGGTGTTCCCTAGCGACCCCCTGGAAATC CAAGGAGGCGAAATTTCCAAGTCGTCTTCGGTTGGCAGTACCAGAGAGTCGTTTGAGAGTGAACGGGGTGCATGG ACCACAGAGATCTCACCCTCTAAAACCTCACTTGATATCAGCGATCATACTGCAGAACTTGATGTCCGGGCAACG GAAACTATTGATCAAACCTCATCACATCGCCGATCAGATACTGGGCAGAGTATTGATAAACCCCGCAATCAGGGG AATCCCATCACAGCTGATGAGACGAAAATAGCAGTAGAGCTGATCTTTGCGGTCATCAATGAGTTGTACACCTTG TCGTCTGCGTGGAACATACGCCGGACCCTTCTGAATGCTGCCAAATCGTATATTCTACGTCCCGGCAGCCCGACA TTGGAAACTATTCGTACGCTGTTGCAAGATTCCATGATAGAAGGCCACACTTCGGACGACGCCCTGGGGTATTAC CTCGTCAAGCTTCGTGAGAACGCGCTTCCGACAGAGGAGGAACTTAAAGCCTGGCCCTCTCCACCCAGTGAGGAG GAGAAGATCCGATTACGGGATACTGCACGTAAACTATTTGTGCAGCGGGGAATTCCACAGGCCTTAACAAGTGTT ATGGGGGCAGCTGCTAGTCGAGAAGCGCTAGAGAAGATCTTTGATAGTCTTCAAGTTGAGAGTGTCGCTCGAGGA TTTGTCTTCTCGATTTTACTACAGGGCCTTAGAGTATTGACTCTTTAA
Gene	>Pro_DTO377G3_2|g4107.t1 ATGAGTCGCCTCAGTGATGACGACTCCGAAGTCATTTCAGCTCCATCCGACAAAGACCACAATACTCCCACGACG AAAGATCCCATCTTAAATACAGCGATCTCAAAGGAACTCATCAATGCTATCCTCAATTTTCTCTCAACCTCTACC AATGAGACCCTCCTTGGAGTCTTTGCGCTTCTTGCACTCGTCACCTATATTGTCCTGGGGAGAATCGGTCTACTT CTGATTGGAGTGGCTGTGGGGGTTGTCCTACACGCGTCCTGGGAGGGATCAGATAACGAACACGGAGAAGAAGCG TCCCACGTGCAAAAGCCCAACCGGCGTAGAGAACTTGCCCTGGAAGTCTCCAACAGACTTTTAGACTGGCCGAGG CGGGCTGGTGCTTCAGACATCCAGGGGGACGATGGTTCTATAAACACGCTGGAAGATATGTCTTCGGCAGACTTG GAGTATGCCACCTTCCAACCGGCCACCGCTGTCGCGCTGAGAACGCTCACCGATGCTGTCATTCAAGATTATGTC AAGTAAGTATCCTCTATTAACGTCCCCTTGTCCAACCGTGAAACAAGTAGCTTATCCCAAATAAAGATACTGGTA TGAGCCACTTTTACCGTCCGAGCCAAGTTTTCCAGACTCCTGTCGAAGGATTTTGACTCATTTCATTACTTCAGT TTCTTCGCACCTCTCGCGGAAACGAACAGAGGACACGTTCTTGCAGTTTCTCACCAACTCCTCATCTATCGTCAT TGTATTCTTGAATGAACTTGCAGCAGCATTCACTGCTGCGAGCTCATCCCCGACGGAAGCCCAAAAAACCGTGGA CCAATACCTTGAACAATTCCCGGATAGCAGCCTAGCGAATGTCTTGTCTGCGGAACAACAAAAGAAAAAACTCAG CATGATCGCGGATGACATACTGTCGAATTTCTTGGATGCCAAAACCTACAATTATCCGGCTGTACGGGACTTCCT CCGTGAGGTCTTTGCGGGCGTGATATTGGGGTCAACTGTTACCAGTCTTGCCCGTCCTGAATTTATCAATGAATG GATTATCTATCTTCTTCAGGGCGGTGAATCCGAAATTATGCACGCTATCGACGCAGGCGTTGAGGGTGCACGGAA CCAGGGTGTCAGTGCTCCTAGGTCTTCAGAACACCCAAAGGCAGACTCCGTCAAAGCCACACAGAGAGATTCCAT GCATGTAGCGAGGGCTACAGAGGAAGAGGCGGTTCTAGAGGTGAAACGTCTGAGTGCTATGATTGTATCCCACGA TACACAGAACTCGGAGTCAGAACGGACGCGCCAAAACGAACAATTTGACGAAAATTACCCTTTGAACACTGATTT GGCTTCAGACACGACTGATGAGAACGAAAACCACGAAGACCAGGGGCCGATACCTAATACGCAATCACTTGCAAG CCCGAAATCATTCGAAGACTCTTCTGTGCCACCTTTGATTCTTCATGGGGCACAAGTGTTGGTAGATGATGATGG AGCAAGGGATGAAAAAGGCCAAATCAAGTCGCGACCCGTGTGGGATTATCTGCTACAGGTCGAACCAGCGTCAAC ACGCTCGACTGGATGGATGGTGTTTCGCAAATATTCGGACTTCCAATCTCTTCACGAGATACTGGGGACCGTTTC ACGATTGAATCAGATTTCGAGTTTCTCGGAGCGTCACCCCATACTGCCCACTTGGAAGGGCAAAACACGACTAGC TCTCGCTCGGGACCTTGGGTGGTATTTACAAGATGCCATGAAGCACGAGTCACTTGCCGACACTGATCGAATGCG GCGATTTTTGCAAAAAGACGCTGGTGCTTCCACTCAACCTAGCTGTAACAACAAACCGGGATTCTCTTTCCCTAG TCAAATTGCGTTTGAACACATGGGCAAGGGTATGCTGGGTGCATTGACCAATGCGCCCAGGGGAGTGGCAGGGGG CGGTAAAGCCGTCTTTGAAGGAATGACAGGGGTGTTTGGCGGCACCGCCAATGGCAAGAAACCGGCTGTCGGTGC TGATCAGATTCAACCCAAAGTTGATGACTCCAGTCGCGCCATCCGGTCGCAGACACGGTTTAGCTTTGCTGATCG TACCGACGTAAGCAACGAAAACGTTGATTCGCCTATGGTGTTCCCTAGCGACCCCCTGGAAATCCAAGGAGGCGA AATTTCCAAGTCGTCTTCGGTTGGCAGTACCAGAGAGTCGTTTGAGAGTGAACGGGGTGCATGGACCACAGAGAT CTCACCCTCTAAAACCTCACTTGATATCAGCGATCATACTGCAGAACTTGATGTCCGGGCAACGGAAACTATTGA TCAAACCTCATCACATCGCCGATCAGATACTGGGCAGAGTATTGATAAACCCCGCAATCAGGGGAATCCCATCAC AGCTGATGAGACGAAAATAGCAGTAGAGCTGATCTTTGCGGTCATCAATGAGTTGTACACCTTGTCGTCTGCGTG GAACATACGCCGGACCCTTCTGAATGCTGCCAAATCGTATATTCTACGTCCCGGCAGCCCGACATTGGAAACTAT TCGTACGCTGTTGCAAGATTCCATGATAGAAGGCCACACTTCGGACGACGCCCTGGGGTATTACCTCGTCAAGCT TCGTGAGAACGCGCTTCCGACAGAGGAGGAACTTAAAGCCTGGCCCTCTCCACCCAGTGAGGAGGAGAAGATCCG ATTACGGGATACTGCACGTAAACTATTTGTGCAGCGGGGAATTCCACAGGCCTTAACAAGTGTTATGGGGGCAGC TGCTAGTCGAGAAGCGCTAGAGAAGATCTTTGATAGTCTTCAAGTTGAGAGTGTCGCTCGAGGATTTGTCTTCTC GATTTTACTACAGGGCCTTAGAGTATTGACTCTTTAA