Fungal Genomics

Agaricus bisporus var bisporus H39 Agaricus bisporus var bisporus H97 Agaricus bisporus var burnettii H119p4 Aspergillus niger CBS 112.32 Aspergillus niger CBS 113.50 Aspergillus niger CBS 115988 Aspergillus niger CBS 115989 Aspergillus niger CBS 118.52 Aspergillus niger CBS 124.48 Aspergillus niger CBS 131.52 Aspergillus niger CBS 133816 Aspergillus niger CBS 147320 Aspergillus niger CBS 147321 Aspergillus niger CBS 147322 Aspergillus niger CBS 147323 Aspergillus niger CBS 147324 Aspergillus niger CBS 147343 Aspergillus niger CBS 147344 Aspergillus niger CBS 147345 Aspergillus niger CBS 147346 Aspergillus niger CBS 147347 Aspergillus niger CBS 147352 Aspergillus niger CBS 147353 Aspergillus niger CBS 147371 Aspergillus niger CBS 147482 Aspergillus niger CBS 630.78 Aspergillus niger CBS 769.97 Niveomyces coronatus CBS 149186 Ophiocordyceps australis 1348a (Ghana) Ophiocordyceps australis map64 (Brazil) Ophiocordyceps camponoti-floridani Ophiocordyceps camponoti-rufipedis Ophiocordyceps kimflemingae Ophiocordyceps subramaniannii Penicillium roqueforti DTO002I6 Penicillium roqueforti DTO003C3 Penicillium roqueforti DTO003H1 (CBS 147308) Penicillium roqueforti DTO006G1 Penicillium roqueforti DTO006G7 Penicillium roqueforti DTO012A1 Penicillium roqueforti DTO012A2 (CBS 147309) Penicillium roqueforti DTO012A6 (CBS 147310) Penicillium roqueforti DTO012A7 Penicillium roqueforti DTO012A8 Penicillium roqueforti DTO012A9 Penicillium roqueforti DTO013E5 Penicillium roqueforti DTO013F2 Penicillium roqueforti DTO013F5 (CBS 147311) Penicillium roqueforti DTO027I6 Penicillium roqueforti DTO032C6 Penicillium roqueforti DTO039G3 Penicillium roqueforti DTO046C5 Penicillium roqueforti DTO070G2 (CBS 147317) Penicillium roqueforti DTO081F9 (CBS 147318) Penicillium roqueforti DTO101D6 (CBS 147325) Penicillium roqueforti DTO102I9 (CBS 147326) Penicillium roqueforti DTO126G2 (CBS 147330) Penicillium roqueforti DTO127F7 (CBS 147331) Penicillium roqueforti DTO127F9 (CBS 147332) Penicillium roqueforti DTO130C1 (CBS 147333) Penicillium roqueforti DTO163C3 (CBS 147337) Penicillium roqueforti DTO163F5 (CBS 147338) Penicillium roqueforti DTO163G4 (CBS 147339) Penicillium roqueforti DTO265D5 (CBS 147372) Penicillium roqueforti DTO369A1 (CBS 147354) Penicillium roqueforti DTO375B1 (CBS 147355) Penicillium roqueforti DTO377G2 (LCP 96.3914a) Penicillium roqueforti LCP96 04111 Rhodonia placenta FPRL280 Torrubiellomyces zombiae CBS 149187

General Properties

Protein ID	Pro_DTO377G3_2|g3628.t1
Gene name
Location	scaffold_06:258945..262090
Strand	+
Gene length (bp)	3145
Transcript length (bp)	3096
Coding sequence length (bp)	3096
Protein length (aa)	1032

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PFAM Domains

PFAM Domain ID	Short name	Long name	E-value	Start	End
PF00773	RNB	RNB domain	4.7E-97	520	852
PF17216	Rrp44_CSD1	Rrp44-like cold shock domain	8.3E-30	255	393
PF17215	Rrp44_S1	S1 domain	2.3E-29	919	1023
PF17849	OB_Dis3	Dis3-like cold-shock domain 2 (CSD2)	8.6E-20	418	485
PF13638	PIN_4	PIN domain	2.8E-08	87	220

GO

GO Term	Description	Terminal node
GO:0003723	RNA binding	Yes
GO:0004540	ribonuclease activity	Yes
GO:0003824	catalytic activity	No
GO:0140640	catalytic activity, acting on a nucleic acid	No
GO:0097159	organic cyclic compound binding	No
GO:0005488	binding	No
GO:0016788	hydrolase activity, acting on ester bonds	No
GO:0140098	catalytic activity, acting on RNA	No
GO:0004518	nuclease activity	No
GO:1901363	heterocyclic compound binding	No
GO:0003676	nucleic acid binding	No
GO:0003674	molecular_function	No
GO:0016787	hydrolase activity	No

SignalP

[Help with interpreting these statistics]

SignalP signal predicted	Location (based on Ymax)	D score (significance: > 0.45)
No	1 - 29	0.45

Transmembrane Domains

(None)

Transcription Factor Class

(None)

Expression data

Analysis 1: Genome-wide gene expression in conidia of Penicillium roqueforti during growth at various temperatures and for various amounts of time. Published in Punt et al., 2020.

Expression values

Label	Description	Expression (RPKM)	Confidence interval (low)	Confidence interval (high)
3d_25C	Three days - 25 degrees Celsius	25.54	15.30	35.78
5d_25C	Five days - 25 degrees Celsius	23.78	14.29	33.28
7d_25C	Seven days - 25 degrees Celsius	25.94	15.55	36.33
10d_25C	Ten days - 25 degrees Celsius	25.13	15.08	35.18
7d_15C	Seven days - 15 degrees Celsius	28.89	17.53	40.26
7d_30C	Seven days - 30 degrees Celsius	25.09	15.03	35.14

Differential expression

Label1	Label2	Q-value	Significant difference
3d_25C	5d_25C	0.819214	no
3d_25C	7d_25C	0.965686	no
3d_25C	7d_15C	0.658568	no
3d_25C	7d_30C	0.960234	no
3d_25C	10d_25C	0.964034	no
5d_25C	7d_25C	0.777428	no
5d_25C	7d_15C	0.445392	no
5d_25C	7d_30C	0.871407	no
5d_25C	10d_25C	0.867593	no
7d_25C	7d_15C	0.711897	no
7d_25C	7d_30C	0.924229	no
7d_25C	10d_25C	0.928910	no
7d_15C	7d_30C	0.602394	no
7d_15C	10d_25C	0.607738	no
7d_30C	10d_25C	0.996031	no

Sequences

Type of sequence	Sequence
Locus	Download genbank file of locus The gene with 5 kb flanks (if sufficient flanking sequence is available). For use in cloning design programs. NOTE: features (genes or exons) that are only partially contained within the sequence are completely excluded.
Protein	>Pro_DTO377G3_2|g3628.t1 MKSLRRDLSANPQAANVTSKVFVRSTKSGKVQKIVRELYLREDIPCSSKLCSQCPTIAPADANGNIAPFILSDRP AGTTAFPRGHYIVPDTNALLNGMDLFEHTGAFYDVIVLQTVLEELRNRSIPLYNRLLALVKSDEKRFYLFFNEFR RETHVRRGPEETINDRNDRAVRMVATWYSSHLQQSAKKGKKEKAIPAIVVITDDKENLRKCKEENVAALSLSDYV SGLEGSEMLLDMISESKDARDAKETTRGEFFYPEYFTMSKLTTGLRAGTLHQGVFNVSPYNYLEASVKTAAFDKP LLILGRDNSNRAIAGDSVVVEVLPQDQWKSPSTKIVDEEAVTRNDNPDTEETDAVVTDRERKALQEEVKKAHGKN SDGKPQPTAKVVGVIKRSWRQYVGHIDSNSTGSQASGRRQQNVFLLPMDKRIPKIRVRTRQASDILGQRILVTID SWDRDSRYPTGHFIRSLGELETKGAETEALLLEYDVQYKPFPKSVLDCLPSEGHNWKVPVSKEDKGWTGRKDLRD LLICSIDPPGCQDIDDALHARLLPNGNFEVGVHIADVSHFVKPNNPMDLEASIRGTTVYLVDKRIDMLPHLLGTD LCSLKPYVERYAFSVQWEMTPDAEIVSSNFSKSVIRSREAFSYEQAQLRIDDKSQQDELTESMRTLLKFSKVLRQ KRMDAGALNLASPEVRIESEGDEVGDPLTDVKTKAMLDTNSLVEEFMLLANITVASKVYESFPQTALLRRHATPP PQNFEDLQKQLSKKRDMELDVSSSRALADSLDRCIDPKNPFFNTLVRILATRCMTSAEYFCAGAFGESEFRHYGL ASPIYTHFTSPIRRYADLMVHRQLASAIGYEGEDGHAVIEGVSTRNKLEDICRNINVRHRNAQHAGRASIEYYVG QALKARGEKMAADGVDAGIEEEGYVMRVFENGVVIFVPRFGIEGVVRLEDFVLPGESGARSVAERRELAPHRTTE FDSEEYTLCVEEKGHPEKERSVTVELFQKVRVNVSSVKEEGRGAGKRRVRILVTEA*
Coding	>Pro_DTO377G3_2|g3628.t1 ATGAAGAGTTTACGAAGAGACTTGTCTGCCAACCCGCAGGCCGCAAATGTTACCAGCAAGGTCTTCGTTAGGTCT ACGAAAAGTGGAAAGGTGCAAAAGATTGTCCGCGAGCTCTATTTGAGAGAAGATATTCCTTGCTCTTCTAAGCTC TGCTCACAATGCCCGACGATTGCGCCGGCTGATGCCAATGGAAACATTGCACCGTTCATCCTATCTGATCGCCCC GCCGGCACAACGGCATTCCCCCGAGGCCACTACATTGTTCCCGATACAAATGCGCTGCTTAATGGAATGGATCTT TTTGAGCACACTGGGGCTTTTTACGATGTGATTGTCCTCCAGACTGTCCTCGAGGAATTGAGAAACCGATCAATA CCACTTTACAACCGTCTTCTGGCCCTCGTCAAGTCAGACGAAAAGCGCTTCTACCTCTTTTTCAACGAGTTTCGC CGAGAGACTCATGTTCGCAGAGGCCCGGAGGAAACAATCAACGACAGGAACGATCGCGCCGTGCGCATGGTAGCA ACCTGGTACAGTTCTCACCTGCAACAATCAGCAAAAAAAGGGAAGAAAGAGAAGGCGATACCGGCAATTGTTGTC ATAACTGATGACAAAGAGAATCTTCGGAAATGCAAGGAAGAAAATGTGGCGGCCTTGTCGCTATCCGACTATGTC TCCGGCTTAGAGGGGTCCGAAATGTTGCTGGATATGATCAGCGAGTCAAAGGATGCGCGAGATGCCAAAGAGACA ACCCGCGGGGAGTTTTTCTACCCTGAATATTTCACAATGTCAAAGCTCACGACTGGTCTGCGAGCCGGGACATTG CACCAGGGAGTGTTCAATGTTTCTCCTTACAACTACCTGGAAGCCTCCGTCAAGACCGCGGCTTTCGATAAACCT CTTCTCATTTTGGGCCGTGATAATAGTAACCGCGCTATTGCGGGTGATTCTGTCGTGGTCGAAGTACTACCACAG GACCAGTGGAAGAGCCCTTCGACTAAGATTGTGGATGAGGAAGCCGTGACCCGTAATGATAACCCTGATACTGAG GAGACCGATGCTGTGGTAACGGACAGAGAACGCAAAGCCCTCCAGGAAGAAGTCAAAAAGGCCCATGGCAAGAAC TCGGATGGCAAGCCACAGCCTACTGCCAAGGTTGTTGGTGTTATCAAGCGCAGCTGGCGTCAATACGTTGGTCAC ATTGACTCGAATTCTACTGGCTCACAGGCCTCTGGTAGACGGCAACAAAACGTTTTCTTACTACCCATGGACAAG CGTATCCCGAAGATCAGAGTACGCACAAGACAGGCTAGCGATATTCTCGGTCAGCGTATTCTTGTCACCATCGAT TCTTGGGACCGCGATTCGAGATATCCTACCGGTCACTTCATTCGGTCTCTGGGAGAGCTCGAAACCAAGGGTGCC GAAACCGAGGCTTTATTGCTTGAATACGACGTGCAGTATAAGCCGTTCCCGAAATCTGTGTTGGACTGCCTTCCA TCTGAAGGTCATAATTGGAAGGTTCCTGTCTCGAAGGAGGATAAAGGCTGGACCGGCCGGAAAGATCTTCGAGAC TTGCTTATTTGCAGTATCGATCCACCCGGCTGTCAGGATATTGACGACGCACTTCACGCGCGTCTTCTGCCAAAT GGAAACTTTGAGGTTGGTGTCCACATTGCAGATGTGTCACATTTCGTCAAACCCAACAACCCAATGGATCTCGAG GCCAGTATTCGCGGAACCACTGTTTACCTAGTCGATAAGCGTATCGACATGCTCCCGCACCTTCTTGGTACAGAT CTTTGCTCTCTCAAGCCCTATGTTGAACGATATGCGTTCTCGGTTCAGTGGGAGATGACACCTGATGCCGAGATA GTGTCTTCAAATTTCAGCAAGTCGGTCATTCGCTCCCGGGAAGCATTCAGTTACGAACAAGCTCAGTTACGCATT GACGACAAATCACAGCAGGACGAGCTGACCGAAAGCATGCGCACTCTCTTGAAATTCTCCAAGGTTCTCCGTCAG AAGCGTATGGACGCTGGTGCCTTGAACCTCGCTTCCCCAGAAGTCCGCATTGAGAGTGAAGGGGATGAAGTGGGC GATCCTTTGACGGACGTCAAGACCAAGGCTATGCTTGACACTAATAGCTTGGTCGAAGAGTTCATGCTTCTCGCC AATATCACTGTTGCCTCGAAGGTCTATGAGTCCTTTCCTCAGACGGCCTTGCTACGTCGGCACGCCACTCCCCCG CCTCAAAATTTCGAGGACCTTCAAAAACAACTCTCGAAGAAGCGAGACATGGAGCTGGATGTTTCCAGCTCACGA GCTCTGGCTGATTCTTTGGATCGTTGTATCGATCCTAAGAACCCATTCTTCAACACCCTGGTCCGTATCTTGGCG ACCCGTTGCATGACCTCTGCCGAGTATTTCTGCGCGGGGGCCTTTGGCGAATCCGAATTCCGTCACTACGGTCTC GCCTCCCCCATTTACACCCACTTTACTTCACCCATTCGACGATATGCCGATCTGATGGTTCACCGGCAATTGGCT TCTGCCATTGGGTATGAAGGTGAGGATGGACACGCAGTTATCGAGGGTGTCAGCACCCGCAACAAGCTAGAAGAC ATCTGCCGGAACATCAACGTCCGTCACCGCAATGCACAGCATGCTGGCCGCGCTAGTATTGAATACTACGTGGGC CAGGCTCTCAAGGCCCGTGGAGAGAAGATGGCCGCCGACGGTGTTGATGCGGGTATTGAAGAAGAAGGATACGTG ATGCGTGTGTTCGAGAACGGTGTTGTCATCTTCGTTCCCCGCTTCGGCATTGAAGGTGTCGTTCGTCTGGAGGAC TTCGTCCTACCCGGTGAATCTGGAGCTCGTTCTGTCGCAGAGAGACGGGAGCTAGCTCCTCACCGCACTACGGAG TTTGATAGCGAGGAATATACCCTTTGTGTGGAGGAGAAGGGTCACCCGGAGAAGGAACGCAGTGTGACTGTTGAA CTTTTCCAAAAGGTTCGTGTCAATGTCAGCTCCGTCAAGGAAGAAGGTCGTGGCGCCGGCAAGAGAAGGGTCCGG ATCTTGGTTACGGAGGCATGA
Transcript	>Pro_DTO377G3_2|g3628.t1 ATGAAGAGTTTACGAAGAGACTTGTCTGCCAACCCGCAGGCCGCAAATGTTACCAGCAAGGTCTTCGTTAGGTCT ACGAAAAGTGGAAAGGTGCAAAAGATTGTCCGCGAGCTCTATTTGAGAGAAGATATTCCTTGCTCTTCTAAGCTC TGCTCACAATGCCCGACGATTGCGCCGGCTGATGCCAATGGAAACATTGCACCGTTCATCCTATCTGATCGCCCC GCCGGCACAACGGCATTCCCCCGAGGCCACTACATTGTTCCCGATACAAATGCGCTGCTTAATGGAATGGATCTT TTTGAGCACACTGGGGCTTTTTACGATGTGATTGTCCTCCAGACTGTCCTCGAGGAATTGAGAAACCGATCAATA CCACTTTACAACCGTCTTCTGGCCCTCGTCAAGTCAGACGAAAAGCGCTTCTACCTCTTTTTCAACGAGTTTCGC CGAGAGACTCATGTTCGCAGAGGCCCGGAGGAAACAATCAACGACAGGAACGATCGCGCCGTGCGCATGGTAGCA ACCTGGTACAGTTCTCACCTGCAACAATCAGCAAAAAAAGGGAAGAAAGAGAAGGCGATACCGGCAATTGTTGTC ATAACTGATGACAAAGAGAATCTTCGGAAATGCAAGGAAGAAAATGTGGCGGCCTTGTCGCTATCCGACTATGTC TCCGGCTTAGAGGGGTCCGAAATGTTGCTGGATATGATCAGCGAGTCAAAGGATGCGCGAGATGCCAAAGAGACA ACCCGCGGGGAGTTTTTCTACCCTGAATATTTCACAATGTCAAAGCTCACGACTGGTCTGCGAGCCGGGACATTG CACCAGGGAGTGTTCAATGTTTCTCCTTACAACTACCTGGAAGCCTCCGTCAAGACCGCGGCTTTCGATAAACCT CTTCTCATTTTGGGCCGTGATAATAGTAACCGCGCTATTGCGGGTGATTCTGTCGTGGTCGAAGTACTACCACAG GACCAGTGGAAGAGCCCTTCGACTAAGATTGTGGATGAGGAAGCCGTGACCCGTAATGATAACCCTGATACTGAG GAGACCGATGCTGTGGTAACGGACAGAGAACGCAAAGCCCTCCAGGAAGAAGTCAAAAAGGCCCATGGCAAGAAC TCGGATGGCAAGCCACAGCCTACTGCCAAGGTTGTTGGTGTTATCAAGCGCAGCTGGCGTCAATACGTTGGTCAC ATTGACTCGAATTCTACTGGCTCACAGGCCTCTGGTAGACGGCAACAAAACGTTTTCTTACTACCCATGGACAAG CGTATCCCGAAGATCAGAGTACGCACAAGACAGGCTAGCGATATTCTCGGTCAGCGTATTCTTGTCACCATCGAT TCTTGGGACCGCGATTCGAGATATCCTACCGGTCACTTCATTCGGTCTCTGGGAGAGCTCGAAACCAAGGGTGCC GAAACCGAGGCTTTATTGCTTGAATACGACGTGCAGTATAAGCCGTTCCCGAAATCTGTGTTGGACTGCCTTCCA TCTGAAGGTCATAATTGGAAGGTTCCTGTCTCGAAGGAGGATAAAGGCTGGACCGGCCGGAAAGATCTTCGAGAC TTGCTTATTTGCAGTATCGATCCACCCGGCTGTCAGGATATTGACGACGCACTTCACGCGCGTCTTCTGCCAAAT GGAAACTTTGAGGTTGGTGTCCACATTGCAGATGTGTCACATTTCGTCAAACCCAACAACCCAATGGATCTCGAG GCCAGTATTCGCGGAACCACTGTTTACCTAGTCGATAAGCGTATCGACATGCTCCCGCACCTTCTTGGTACAGAT CTTTGCTCTCTCAAGCCCTATGTTGAACGATATGCGTTCTCGGTTCAGTGGGAGATGACACCTGATGCCGAGATA GTGTCTTCAAATTTCAGCAAGTCGGTCATTCGCTCCCGGGAAGCATTCAGTTACGAACAAGCTCAGTTACGCATT GACGACAAATCACAGCAGGACGAGCTGACCGAAAGCATGCGCACTCTCTTGAAATTCTCCAAGGTTCTCCGTCAG AAGCGTATGGACGCTGGTGCCTTGAACCTCGCTTCCCCAGAAGTCCGCATTGAGAGTGAAGGGGATGAAGTGGGC GATCCTTTGACGGACGTCAAGACCAAGGCTATGCTTGACACTAATAGCTTGGTCGAAGAGTTCATGCTTCTCGCC AATATCACTGTTGCCTCGAAGGTCTATGAGTCCTTTCCTCAGACGGCCTTGCTACGTCGGCACGCCACTCCCCCG CCTCAAAATTTCGAGGACCTTCAAAAACAACTCTCGAAGAAGCGAGACATGGAGCTGGATGTTTCCAGCTCACGA GCTCTGGCTGATTCTTTGGATCGTTGTATCGATCCTAAGAACCCATTCTTCAACACCCTGGTCCGTATCTTGGCG ACCCGTTGCATGACCTCTGCCGAGTATTTCTGCGCGGGGGCCTTTGGCGAATCCGAATTCCGTCACTACGGTCTC GCCTCCCCCATTTACACCCACTTTACTTCACCCATTCGACGATATGCCGATCTGATGGTTCACCGGCAATTGGCT TCTGCCATTGGGTATGAAGGTGAGGATGGACACGCAGTTATCGAGGGTGTCAGCACCCGCAACAAGCTAGAAGAC ATCTGCCGGAACATCAACGTCCGTCACCGCAATGCACAGCATGCTGGCCGCGCTAGTATTGAATACTACGTGGGC CAGGCTCTCAAGGCCCGTGGAGAGAAGATGGCCGCCGACGGTGTTGATGCGGGTATTGAAGAAGAAGGATACGTG ATGCGTGTGTTCGAGAACGGTGTTGTCATCTTCGTTCCCCGCTTCGGCATTGAAGGTGTCGTTCGTCTGGAGGAC TTCGTCCTACCCGGTGAATCTGGAGCTCGTTCTGTCGCAGAGAGACGGGAGCTAGCTCCTCACCGCACTACGGAG TTTGATAGCGAGGAATATACCCTTTGTGTGGAGGAGAAGGGTCACCCGGAGAAGGAACGCAGTGTGACTGTTGAA CTTTTCCAAAAGGTTCGTGTCAATGTCAGCTCCGTCAAGGAAGAAGGTCGTGGCGCCGGCAAGAGAAGGGTCCGG ATCTTGGTTACGGAGGCATGA
Gene	>Pro_DTO377G3_2|g3628.t1 ATGAAGAGTTTACGAAGAGACTTGTCTGCCAACCCGCAGGCCGCAAATGTTACCAGCAAGGTCTTCGTTAGGTCT ACGAAAAGTGGAAAGGTGCAAAAGATTGTCCGCGAGCTCTATTTGAGAGAAGATATTCCTTGCTCTTCTAAGCTC TGCTCACAATGCCCGACGATTGCGCCGGCTGATGCCAATGGAAACAGTAAGGAAATTATTACGGTAATGGTCAAG CAAGTTGCTAATCGAAACAGTTGCACCGTTCATCCTATCTGATCGCCCCGCCGGCACAACGGCATTCCCCCGAGG CCACTACATTGTTCCCGATACAAATGCGCTGCTTAATGGAATGGATCTTTTTGAGCACACTGGGGCTTTTTACGA TGTGATTGTCCTCCAGACTGTCCTCGAGGAATTGAGAAACCGATCAATACCACTTTACAACCGTCTTCTGGCCCT CGTCAAGTCAGACGAAAAGCGCTTCTACCTCTTTTTCAACGAGTTTCGCCGAGAGACTCATGTTCGCAGAGGCCC GGAGGAAACAATCAACGACAGGAACGATCGCGCCGTGCGCATGGTAGCAACCTGGTACAGTTCTCACCTGCAACA ATCAGCAAAAAAAGGGAAGAAAGAGAAGGCGATACCGGCAATTGTTGTCATAACTGATGACAAAGAGAATCTTCG GAAATGCAAGGAAGAAAATGTGGCGGCCTTGTCGCTATCCGACTATGTCTCCGGCTTAGAGGGGTCCGAAATGTT GCTGGATATGATCAGCGAGTCAAAGGATGCGCGAGATGCCAAAGAGACAACCCGCGGGGAGTTTTTCTACCCTGA ATATTTCACAATGTCAAAGCTCACGACTGGTCTGCGAGCCGGGACATTGCACCAGGGAGTGTTCAATGTTTCTCC TTACAACTACCTGGAAGCCTCCGTCAAGACCGCGGCTTTCGATAAACCTCTTCTCATTTTGGGCCGTGATAATAG TAACCGCGCTATTGCGGGTGATTCTGTCGTGGTCGAAGTACTACCACAGGACCAGTGGAAGAGCCCTTCGACTAA GATTGTGGATGAGGAAGCCGTGACCCGTAATGATAACCCTGATACTGAGGAGACCGATGCTGTGGTAACGGACAG AGAACGCAAAGCCCTCCAGGAAGAAGTCAAAAAGGCCCATGGCAAGAACTCGGATGGCAAGCCACAGCCTACTGC CAAGGTTGTTGGTGTTATCAAGCGCAGCTGGCGTCAATACGTTGGTCACATTGACTCGAATTCTACTGGCTCACA GGCCTCTGGTAGACGGCAACAAAACGTTTTCTTACTACCCATGGACAAGCGTATCCCGAAGATCAGAGTACGCAC AAGACAGGCTAGCGATATTCTCGGTCAGCGTATTCTTGTCACCATCGATTCTTGGGACCGCGATTCGAGATATCC TACCGGTCACTTCATTCGGTCTCTGGGAGAGCTCGAAACCAAGGGTGCCGAAACCGAGGCTTTATTGCTTGAATA CGACGTGCAGTATAAGCCGTTCCCGAAATCTGTGTTGGACTGCCTTCCATCTGAAGGTCATAATTGGAAGGTTCC TGTCTCGAAGGAGGATAAAGGCTGGACCGGCCGGAAAGATCTTCGAGACTTGCTTATTTGCAGTATCGATCCACC CGGCTGTCAGGATATTGACGACGCACTTCACGCGCGTCTTCTGCCAAATGGAAACTTTGAGGTTGGTGTCCACAT TGCAGATGTGTCACATTTCGTCAAACCCAACAACCCAATGGATCTCGAGGCCAGTATTCGCGGAACCACTGTTTA CCTAGTCGATAAGCGTATCGACATGCTCCCGCACCTTCTTGGTACAGATCTTTGCTCTCTCAAGCCCTATGTTGA ACGATATGCGTTCTCGGTTCAGTGGGAGATGACACCTGATGCCGAGATAGTGTCTTCAAATTTCAGCAAGTCGGT CATTCGCTCCCGGGAAGCATTCAGTTACGAACAAGCTCAGTTACGCATTGACGACAAATCACAGCAGGACGAGCT GACCGAAAGCATGCGCACTCTCTTGAAATTCTCCAAGGTTCTCCGTCAGAAGCGTATGGACGCTGGTGCCTTGAA CCTCGCTTCCCCAGAAGTCCGCATTGAGAGTGAAGGGGATGAAGTGGGCGATCCTTTGACGGACGTCAAGACCAA GGCTATGCTTGACACTAATAGCTTGGTCGAAGAGTTCATGCTTCTCGCCAATATCACTGTTGCCTCGAAGGTCTA TGAGTCCTTTCCTCAGACGGCCTTGCTACGTCGGCACGCCACTCCCCCGCCTCAAAATTTCGAGGACCTTCAAAA ACAACTCTCGAAGAAGCGAGACATGGAGCTGGATGTTTCCAGCTCACGAGCTCTGGCTGATTCTTTGGATCGTTG TATCGATCCTAAGAACCCATTCTTCAACACCCTGGTCCGTATCTTGGCGACCCGTTGCATGACCTCTGCCGAGTA TTTCTGCGCGGGGGCCTTTGGCGAATCCGAATTCCGTCACTACGGTCTCGCCTCCCCCATTTACACCCACTTTAC TTCACCCATTCGACGATATGCCGATCTGATGGTTCACCGGCAATTGGCTTCTGCCATTGGGTATGAAGGTGAGGA TGGACACGCAGTTATCGAGGGTGTCAGCACCCGCAACAAGCTAGAAGACATCTGCCGGAACATCAACGTCCGTCA CCGCAATGCACAGCATGCTGGCCGCGCTAGTATTGAATACTACGTGGGCCAGGCTCTCAAGGCCCGTGGAGAGAA GATGGCCGCCGACGGTGTTGATGCGGGTATTGAAGAAGAAGGATACGTGATGCGTGTGTTCGAGAACGGTGTTGT CATCTTCGTTCCCCGCTTCGGCATTGAAGGTGTCGTTCGTCTGGAGGACTTCGTCCTACCCGGTGAATCTGGAGC TCGTTCTGTCGCAGAGAGACGGGAGCTAGCTCCTCACCGCACTACGGAGTTTGATAGCGAGGAATATACCCTTTG TGTGGAGGAGAAGGGTCACCCGGAGAAGGAACGCAGTGTGACTGTTGAACTTTTCCAAAAGGTTCGTGTCAATGT CAGCTCCGTCAAGGAAGAAGGTCGTGGCGCCGGCAAGAGAAGGGTCCGGATCTTGGTTACGGAGGCATGA