Fungal Genomics

Agaricus bisporus var bisporus H39 Agaricus bisporus var bisporus H97 Agaricus bisporus var burnettii H119p4 Aspergillus niger CBS 112.32 Aspergillus niger CBS 113.50 Aspergillus niger CBS 115988 Aspergillus niger CBS 115989 Aspergillus niger CBS 118.52 Aspergillus niger CBS 124.48 Aspergillus niger CBS 131.52 Aspergillus niger CBS 133816 Aspergillus niger CBS 147320 Aspergillus niger CBS 147321 Aspergillus niger CBS 147322 Aspergillus niger CBS 147323 Aspergillus niger CBS 147324 Aspergillus niger CBS 147343 Aspergillus niger CBS 147344 Aspergillus niger CBS 147345 Aspergillus niger CBS 147346 Aspergillus niger CBS 147347 Aspergillus niger CBS 147352 Aspergillus niger CBS 147353 Aspergillus niger CBS 147371 Aspergillus niger CBS 147482 Aspergillus niger CBS 630.78 Aspergillus niger CBS 769.97 Niveomyces coronatus CBS 149186 Ophiocordyceps australis 1348a (Ghana) Ophiocordyceps australis map64 (Brazil) Ophiocordyceps camponoti-floridani Ophiocordyceps camponoti-rufipedis Ophiocordyceps kimflemingae Ophiocordyceps subramaniannii Penicillium roqueforti DTO002I6 Penicillium roqueforti DTO003C3 Penicillium roqueforti DTO003H1 (CBS 147308) Penicillium roqueforti DTO006G1 Penicillium roqueforti DTO006G7 Penicillium roqueforti DTO012A1 Penicillium roqueforti DTO012A2 (CBS 147309) Penicillium roqueforti DTO012A6 (CBS 147310) Penicillium roqueforti DTO012A7 Penicillium roqueforti DTO012A8 Penicillium roqueforti DTO012A9 Penicillium roqueforti DTO013E5 Penicillium roqueforti DTO013F2 Penicillium roqueforti DTO013F5 (CBS 147311) Penicillium roqueforti DTO027I6 Penicillium roqueforti DTO032C6 Penicillium roqueforti DTO039G3 Penicillium roqueforti DTO046C5 Penicillium roqueforti DTO070G2 (CBS 147317) Penicillium roqueforti DTO081F9 (CBS 147318) Penicillium roqueforti DTO101D6 (CBS 147325) Penicillium roqueforti DTO102I9 (CBS 147326) Penicillium roqueforti DTO126G2 (CBS 147330) Penicillium roqueforti DTO127F7 (CBS 147331) Penicillium roqueforti DTO127F9 (CBS 147332) Penicillium roqueforti DTO130C1 (CBS 147333) Penicillium roqueforti DTO163C3 (CBS 147337) Penicillium roqueforti DTO163F5 (CBS 147338) Penicillium roqueforti DTO163G4 (CBS 147339) Penicillium roqueforti DTO265D5 (CBS 147372) Penicillium roqueforti DTO369A1 (CBS 147354) Penicillium roqueforti DTO375B1 (CBS 147355) Penicillium roqueforti DTO377G2 (LCP 96.3914a) Penicillium roqueforti LCP96 04111 Rhodonia placenta FPRL280 Torrubiellomyces zombiae CBS 149187

General Properties

Protein ID	Pro_DTO377G3_2|g3232.t1
Gene name
Location	scaffold_05:50735..54406
Strand	+
Gene length (bp)	3671
Transcript length (bp)	3618
Coding sequence length (bp)	3618
Protein length (aa)	1206

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PFAM Domains

PFAM Domain ID	Short name	Long name	E-value	Start	End
PF00122	E1-E2_ATPase	E1-E2 ATPase	6.6E-48	688	877
PF00702	Hydrolase	haloacid dehalogenase-like hydrolase	2.1E-21	896	1107
PF00403	HMA	Heavy-metal-associated domain	5.9E-06	410	457

GO

GO Term	Description	Terminal node
GO:0046872	metal ion binding	Yes
GO:0005488	binding	No
GO:0043167	ion binding	No
GO:0043169	cation binding	No
GO:0003674	molecular_function	No

SignalP

[Help with interpreting these statistics]

SignalP signal predicted	Location (based on Ymax)	D score (significance: > 0.45)
No	1 - 11	0.45

Transmembrane Domains

Domain #	Start	End	Length
1	557	579	22
2	584	606	22
3	621	643	22
4	806	828	22
5	848	870	22
6	1152	1171	19
7	1181	1203	22

Transcription Factor Class

(None)

Expression data

Analysis 1: Genome-wide gene expression in conidia of Penicillium roqueforti during growth at various temperatures and for various amounts of time. Published in Punt et al., 2020.

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Sequences

Type of sequence	Sequence
Locus	Download genbank file of locus The gene with 5 kb flanks (if sufficient flanking sequence is available). For use in cloning design programs. NOTE: features (genes or exons) that are only partially contained within the sequence are completely excluded.
Protein	>Pro_DTO377G3_2|g3232.t1 MEGDYCGLPTPAPEPNVTALAAPSEKPSSCQDSCCDSDDTEHTPAPGQKTPAPEKLDDCCSPEKCADNKSENHTD APDCCRGKVSPCCDTSCLDRLAMRECEMSAMAAPGPNSQPNTCGGATDHKACNQHSLSALDRYGATLQALGCICR ALIALGQETCCEIRDRQSLDGKQCSKKSSARSFRISLNSCSNGSVTKDQAAQNRSRLRRGSRESTRSVEKASAHA CVVALCSKDKPAKEPPVKSKCPEPCCSEDTPTTAPLVKDNCAKSCYSLEKPDVSCPGSCCPRDQRVKDNNTKSVY ADLCCSKVGSVVEPLTSGCAGSFCGTAKNTISKQLPNAASSGSCCKPPKQDIVSCADSRCTEKQPANPQGSCTDA CCSSAVPDPGLEIEEASIQAITDIENQSTGKEHVVLSISGMTCTGCETKLSRTLDTLPAVKDLKTSLVLSRAEFN IDLRLSSVEEVMKHLERTTEFKCKRVQNQGSSLDLIVPDEPSNFISQTWPDGVLDMAPVDKQTVRVAFDPNIVGA RELSKIWGPPIELAPPRGDPSLEAGSKHVRHVGYMTLLSAVLTIPVLVMAWASLPDGEVAYSSASLTLATIVQVV IAGPFYPKALKALIFSRVIEMDLLIVLSTSAAYIFSVVSFGYLIAEQPLSTGQFFETSTLLVTLIMVGRWVAALA RQRAVESISIRSLQASTAILVDQKSGTEREIDARLLQYGDTFKVLPDTRIPTDGTVINGSSEVDESMLTGESRPV EKYPKSVVVAGSVNGSGVMTVRLNRLPSDNTINAIAAMVDEAKLSKPKLQDLADRVASYFVPVVLALTIITFVIW VAVGMTVRGYDGSEATIQAITYAITVLIVSCPCAIGLAVPMVIVIASGVAAERGIIFKSSDAIEVAHKTSHVVFD KTGTLTRGKLSVVTTECANVDKLPLLLGLIENNRHPVSVSVAAHLKDAGVTASTVPEPKSLTGKGVETTFGGRKL RAGNSRWLNLSENEVVQPMLAQGYTVFCFTIDNALQAVYGLEDELRPDAAGTIETLHRRGVSVHVVSGDDDGAVR SLASKLSIPGGQVRSRSSPADKKDYIQTLLRTRIDRKEPVVVFCGDGTNDAVALAQATIGVHMNEGTDVAQSAAD VVLMRPFLAGIPTMMDASRKSVNRIKFNFIWSFVYNTFAVLLAAGAFVNARIPPEFAGLGELVSVLPVIAAALLL RWSKF*
Coding	>Pro_DTO377G3_2|g3232.t1 ATGGAAGGCGACTATTGCGGCCTACCGACTCCGGCCCCTGAGCCCAATGTTACGGCACTCGCGGCTCCAAGTGAG AAGCCGAGCAGTTGCCAGGATTCTTGCTGCGATAGCGACGACACTGAGCACACCCCGGCCCCGGGTCAGAAAACG CCCGCCCCGGAAAAACTGGATGATTGCTGCTCTCCTGAAAAATGTGCGGACAACAAATCCGAGAATCATACCGAC GCGCCTGACTGCTGCCGTGGCAAAGTCAGCCCATGCTGCGACACGTCTTGCCTTGACCGCTTGGCTATGCGGGAA TGCGAGATGAGTGCTATGGCTGCCCCCGGCCCAAACAGTCAGCCAAACACTTGCGGTGGAGCTACCGACCACAAG GCATGCAACCAACATAGTCTCTCTGCCCTCGACCGCTACGGCGCTACTCTACAGGCTCTGGGATGTATCTGCCGC GCTCTTATTGCTCTTGGCCAGGAAACCTGCTGTGAAATTCGCGACCGACAGTCACTGGACGGGAAGCAGTGCTCT AAGAAGTCGTCTGCTCGCTCCTTTCGCATTTCACTGAATTCCTGCAGCAACGGCTCAGTCACCAAGGACCAGGCC GCGCAGAACCGTTCTCGCCTGCGAAGGGGCTCTCGTGAAAGCACCAGGTCTGTCGAGAAGGCGTCCGCCCATGCC TGTGTTGTCGCTTTGTGTTCGAAGGACAAGCCCGCCAAAGAGCCTCCTGTCAAAAGCAAGTGCCCGGAGCCGTGC TGCTCTGAGGACACTCCCACCACGGCTCCATTAGTTAAGGATAACTGTGCCAAGTCTTGCTACTCCCTCGAAAAG CCCGATGTCAGCTGCCCCGGATCTTGCTGTCCCAGAGACCAGCGTGTCAAAGACAATAACACCAAGAGCGTTTAT GCGGACCTATGCTGTTCGAAGGTCGGATCCGTTGTTGAACCTCTAACTAGTGGGTGTGCAGGGTCTTTTTGTGGA ACAGCTAAGAACACGATTAGCAAACAGCTACCTAACGCCGCCTCCTCTGGCTCTTGCTGTAAGCCACCGAAGCAG GATATCGTTAGTTGCGCAGATTCTCGCTGCACAGAAAAGCAGCCGGCCAACCCCCAAGGCTCTTGCACTGATGCT TGCTGCTCTTCTGCTGTGCCCGACCCTGGTTTAGAGATTGAGGAAGCCTCGATTCAGGCTATCACCGACATAGAG AATCAGAGTACCGGCAAGGAACATGTTGTCCTCAGCATTTCTGGCATGACTTGTACTGGTTGCGAGACAAAGCTT AGCCGAACCTTGGATACTCTCCCCGCCGTCAAAGACCTGAAAACCAGTCTGGTTCTCTCACGAGCCGAGTTCAAC ATTGATCTGCGCCTTAGCTCAGTTGAGGAAGTCATGAAACATCTGGAGCGAACCACTGAATTTAAGTGCAAAAGA GTCCAGAACCAGGGATCTAGCCTAGATCTTATTGTCCCTGATGAGCCCTCGAATTTCATTAGTCAGACGTGGCCG GACGGAGTTCTCGACATGGCACCTGTAGACAAGCAGACTGTGCGAGTTGCGTTTGATCCGAATATCGTGGGAGCT CGAGAACTCTCCAAGATTTGGGGTCCGCCAATTGAACTTGCTCCTCCACGTGGCGACCCTTCGCTGGAGGCTGGC AGCAAGCATGTTCGTCATGTCGGATACATGACGCTTCTCTCCGCTGTCTTAACGATTCCGGTCCTAGTCATGGCA TGGGCTTCGCTTCCTGACGGGGAGGTGGCATATTCATCGGCTTCACTCACATTGGCCACGATTGTTCAAGTTGTC ATAGCAGGGCCTTTCTATCCTAAGGCCCTGAAGGCTCTCATTTTCTCGAGGGTTATCGAGATGGACCTCTTGATC GTCTTGAGCACCAGTGCTGCCTACATATTCTCGGTGGTCTCCTTTGGGTACCTCATTGCAGAGCAGCCCCTTTCG ACTGGTCAATTCTTTGAAACGAGCACTCTCTTAGTCACCTTGATCATGGTTGGTCGATGGGTTGCCGCTCTCGCT CGTCAGAGAGCTGTTGAATCTATTTCTATCCGGTCACTTCAGGCATCGACAGCTATCCTTGTCGACCAAAAGAGC GGAACGGAACGTGAGATTGACGCCCGACTTCTTCAATACGGCGACACCTTCAAAGTTCTCCCTGACACCAGAATC CCGACAGACGGCACTGTCATCAATGGGTCGTCTGAGGTTGACGAGTCTATGCTCACTGGTGAATCTAGACCAGTA GAGAAATATCCCAAGTCTGTGGTGGTTGCTGGGTCTGTCAATGGCTCTGGAGTTATGACTGTTCGACTGAACCGC TTGCCTAGCGATAACACTATCAATGCCATTGCTGCGATGGTCGATGAGGCCAAACTGTCGAAACCTAAGCTGCAG GATCTCGCAGACCGGGTAGCGTCCTACTTCGTCCCGGTTGTGCTGGCATTGACAATCATCACGTTCGTCATCTGG GTTGCAGTAGGCATGACTGTTCGTGGATATGATGGATCCGAAGCTACAATTCAGGCCATCACCTATGCCATTACT GTCCTCATTGTTTCTTGCCCCTGCGCCATTGGACTGGCTGTTCCTATGGTCATTGTGATTGCCAGCGGAGTCGCG GCGGAAAGAGGTATCATCTTCAAGTCATCAGATGCTATTGAAGTGGCTCATAAGACGTCGCACGTCGTGTTTGAC AAGACTGGGACCTTGACTCGGGGAAAGCTTTCTGTCGTAACGACGGAGTGCGCCAACGTGGACAAGCTCCCGCTT CTTCTAGGCCTCATCGAGAACAACCGACATCCAGTCTCAGTTTCTGTGGCTGCTCACCTCAAGGATGCCGGAGTT ACGGCTTCGACTGTTCCTGAGCCCAAGAGCCTTACTGGCAAAGGTGTTGAAACCACCTTTGGTGGCCGGAAACTT CGAGCAGGCAATTCTCGCTGGCTGAATTTATCGGAAAATGAAGTTGTTCAGCCAATGCTTGCTCAAGGGTACACT GTCTTCTGCTTTACTATCGACAATGCGTTACAGGCGGTCTATGGTCTTGAAGATGAGCTTCGACCTGACGCTGCG GGAACGATTGAGACCTTACACAGGCGTGGCGTCTCGGTACATGTCGTTTCTGGCGACGATGACGGAGCTGTTCGG TCTTTGGCGTCCAAGCTTAGCATTCCTGGCGGTCAAGTGCGTTCTCGAAGCTCGCCCGCCGACAAGAAGGACTAT ATCCAGACACTCCTCCGTACTCGCATAGATCGTAAGGAACCGGTTGTTGTTTTCTGCGGTGACGGCACGAACGAT GCTGTTGCTCTCGCACAGGCTACGATTGGCGTCCACATGAACGAAGGCACAGATGTCGCGCAATCCGCCGCGGAC GTGGTTCTCATGCGGCCTTTTCTGGCTGGTATCCCCACCATGATGGACGCCAGTCGGAAATCTGTCAACCGCATC AAGTTCAACTTTATATGGAGCTTCGTATACAATACCTTTGCAGTCCTTCTCGCTGCGGGTGCTTTTGTCAATGCC AGAATTCCCCCAGAGTTTGCGGGACTGGGAGAGTTGGTGAGTGTGTTGCCAGTCATTGCTGCTGCGCTGCTTCTG CGCTGGTCGAAGTTCTAG
Transcript	>Pro_DTO377G3_2|g3232.t1 ATGGAAGGCGACTATTGCGGCCTACCGACTCCGGCCCCTGAGCCCAATGTTACGGCACTCGCGGCTCCAAGTGAG AAGCCGAGCAGTTGCCAGGATTCTTGCTGCGATAGCGACGACACTGAGCACACCCCGGCCCCGGGTCAGAAAACG CCCGCCCCGGAAAAACTGGATGATTGCTGCTCTCCTGAAAAATGTGCGGACAACAAATCCGAGAATCATACCGAC GCGCCTGACTGCTGCCGTGGCAAAGTCAGCCCATGCTGCGACACGTCTTGCCTTGACCGCTTGGCTATGCGGGAA TGCGAGATGAGTGCTATGGCTGCCCCCGGCCCAAACAGTCAGCCAAACACTTGCGGTGGAGCTACCGACCACAAG GCATGCAACCAACATAGTCTCTCTGCCCTCGACCGCTACGGCGCTACTCTACAGGCTCTGGGATGTATCTGCCGC GCTCTTATTGCTCTTGGCCAGGAAACCTGCTGTGAAATTCGCGACCGACAGTCACTGGACGGGAAGCAGTGCTCT AAGAAGTCGTCTGCTCGCTCCTTTCGCATTTCACTGAATTCCTGCAGCAACGGCTCAGTCACCAAGGACCAGGCC GCGCAGAACCGTTCTCGCCTGCGAAGGGGCTCTCGTGAAAGCACCAGGTCTGTCGAGAAGGCGTCCGCCCATGCC TGTGTTGTCGCTTTGTGTTCGAAGGACAAGCCCGCCAAAGAGCCTCCTGTCAAAAGCAAGTGCCCGGAGCCGTGC TGCTCTGAGGACACTCCCACCACGGCTCCATTAGTTAAGGATAACTGTGCCAAGTCTTGCTACTCCCTCGAAAAG CCCGATGTCAGCTGCCCCGGATCTTGCTGTCCCAGAGACCAGCGTGTCAAAGACAATAACACCAAGAGCGTTTAT GCGGACCTATGCTGTTCGAAGGTCGGATCCGTTGTTGAACCTCTAACTAGTGGGTGTGCAGGGTCTTTTTGTGGA ACAGCTAAGAACACGATTAGCAAACAGCTACCTAACGCCGCCTCCTCTGGCTCTTGCTGTAAGCCACCGAAGCAG GATATCGTTAGTTGCGCAGATTCTCGCTGCACAGAAAAGCAGCCGGCCAACCCCCAAGGCTCTTGCACTGATGCT TGCTGCTCTTCTGCTGTGCCCGACCCTGGTTTAGAGATTGAGGAAGCCTCGATTCAGGCTATCACCGACATAGAG AATCAGAGTACCGGCAAGGAACATGTTGTCCTCAGCATTTCTGGCATGACTTGTACTGGTTGCGAGACAAAGCTT AGCCGAACCTTGGATACTCTCCCCGCCGTCAAAGACCTGAAAACCAGTCTGGTTCTCTCACGAGCCGAGTTCAAC ATTGATCTGCGCCTTAGCTCAGTTGAGGAAGTCATGAAACATCTGGAGCGAACCACTGAATTTAAGTGCAAAAGA GTCCAGAACCAGGGATCTAGCCTAGATCTTATTGTCCCTGATGAGCCCTCGAATTTCATTAGTCAGACGTGGCCG GACGGAGTTCTCGACATGGCACCTGTAGACAAGCAGACTGTGCGAGTTGCGTTTGATCCGAATATCGTGGGAGCT CGAGAACTCTCCAAGATTTGGGGTCCGCCAATTGAACTTGCTCCTCCACGTGGCGACCCTTCGCTGGAGGCTGGC AGCAAGCATGTTCGTCATGTCGGATACATGACGCTTCTCTCCGCTGTCTTAACGATTCCGGTCCTAGTCATGGCA TGGGCTTCGCTTCCTGACGGGGAGGTGGCATATTCATCGGCTTCACTCACATTGGCCACGATTGTTCAAGTTGTC ATAGCAGGGCCTTTCTATCCTAAGGCCCTGAAGGCTCTCATTTTCTCGAGGGTTATCGAGATGGACCTCTTGATC GTCTTGAGCACCAGTGCTGCCTACATATTCTCGGTGGTCTCCTTTGGGTACCTCATTGCAGAGCAGCCCCTTTCG ACTGGTCAATTCTTTGAAACGAGCACTCTCTTAGTCACCTTGATCATGGTTGGTCGATGGGTTGCCGCTCTCGCT CGTCAGAGAGCTGTTGAATCTATTTCTATCCGGTCACTTCAGGCATCGACAGCTATCCTTGTCGACCAAAAGAGC GGAACGGAACGTGAGATTGACGCCCGACTTCTTCAATACGGCGACACCTTCAAAGTTCTCCCTGACACCAGAATC CCGACAGACGGCACTGTCATCAATGGGTCGTCTGAGGTTGACGAGTCTATGCTCACTGGTGAATCTAGACCAGTA GAGAAATATCCCAAGTCTGTGGTGGTTGCTGGGTCTGTCAATGGCTCTGGAGTTATGACTGTTCGACTGAACCGC TTGCCTAGCGATAACACTATCAATGCCATTGCTGCGATGGTCGATGAGGCCAAACTGTCGAAACCTAAGCTGCAG GATCTCGCAGACCGGGTAGCGTCCTACTTCGTCCCGGTTGTGCTGGCATTGACAATCATCACGTTCGTCATCTGG GTTGCAGTAGGCATGACTGTTCGTGGATATGATGGATCCGAAGCTACAATTCAGGCCATCACCTATGCCATTACT GTCCTCATTGTTTCTTGCCCCTGCGCCATTGGACTGGCTGTTCCTATGGTCATTGTGATTGCCAGCGGAGTCGCG GCGGAAAGAGGTATCATCTTCAAGTCATCAGATGCTATTGAAGTGGCTCATAAGACGTCGCACGTCGTGTTTGAC AAGACTGGGACCTTGACTCGGGGAAAGCTTTCTGTCGTAACGACGGAGTGCGCCAACGTGGACAAGCTCCCGCTT CTTCTAGGCCTCATCGAGAACAACCGACATCCAGTCTCAGTTTCTGTGGCTGCTCACCTCAAGGATGCCGGAGTT ACGGCTTCGACTGTTCCTGAGCCCAAGAGCCTTACTGGCAAAGGTGTTGAAACCACCTTTGGTGGCCGGAAACTT CGAGCAGGCAATTCTCGCTGGCTGAATTTATCGGAAAATGAAGTTGTTCAGCCAATGCTTGCTCAAGGGTACACT GTCTTCTGCTTTACTATCGACAATGCGTTACAGGCGGTCTATGGTCTTGAAGATGAGCTTCGACCTGACGCTGCG GGAACGATTGAGACCTTACACAGGCGTGGCGTCTCGGTACATGTCGTTTCTGGCGACGATGACGGAGCTGTTCGG TCTTTGGCGTCCAAGCTTAGCATTCCTGGCGGTCAAGTGCGTTCTCGAAGCTCGCCCGCCGACAAGAAGGACTAT ATCCAGACACTCCTCCGTACTCGCATAGATCGTAAGGAACCGGTTGTTGTTTTCTGCGGTGACGGCACGAACGAT GCTGTTGCTCTCGCACAGGCTACGATTGGCGTCCACATGAACGAAGGCACAGATGTCGCGCAATCCGCCGCGGAC GTGGTTCTCATGCGGCCTTTTCTGGCTGGTATCCCCACCATGATGGACGCCAGTCGGAAATCTGTCAACCGCATC AAGTTCAACTTTATATGGAGCTTCGTATACAATACCTTTGCAGTCCTTCTCGCTGCGGGTGCTTTTGTCAATGCC AGAATTCCCCCAGAGTTTGCGGGACTGGGAGAGTTGGTGAGTGTGTTGCCAGTCATTGCTGCTGCGCTGCTTCTG CGCTGGTCGAAGTTCTAG
Gene	>Pro_DTO377G3_2|g3232.t1 ATGGAAGGCGACTATTGCGGCCTACCGACTCCGGCCCCTGAGCCCAATGTTACGGCACTCGCGGCTCCAAGTGAG AAGCCGAGCAGTTGCCAGGATTCTTGCTGCGATAGCGACGACACTGAGCACACCCCGGCCCCGGGTCAGAAAACG CCCGCCCCGGAAAAACTGGATGATTGCTGCTCTCCTGAAAAATGTGCGGACAACAAATCCGAGAATCATACCGAC GCGCCTGACTGCTGCCGTGGCAAAGTCAGCCCATGCTGCGACACGTCTTGCCTTGACCGCTTGGCTATGCGGGAA TGCGAGATGAGTGCTATGGCTGCCCCCGGCCCAAACAGTCAGCCAAACAGTGAGTGTCCGCCCTTTGAGAATGGC ATTCAAAGATTGCTAACTCCCTTTCAGCTTGCGGTGGAGCTACCGACCACAAGGCATGCAACCAACATAGTCTCT CTGCCCTCGACCGCTACGGCGCTACTCTACAGGCTCTGGGATGTATCTGCCGCGCTCTTATTGCTCTTGGCCAGG AAACCTGCTGTGAAATTCGCGACCGACAGTCACTGGACGGGAAGCAGTGCTCTAAGAAGTCGTCTGCTCGCTCCT TTCGCATTTCACTGAATTCCTGCAGCAACGGCTCAGTCACCAAGGACCAGGCCGCGCAGAACCGTTCTCGCCTGC GAAGGGGCTCTCGTGAAAGCACCAGGTCTGTCGAGAAGGCGTCCGCCCATGCCTGTGTTGTCGCTTTGTGTTCGA AGGACAAGCCCGCCAAAGAGCCTCCTGTCAAAAGCAAGTGCCCGGAGCCGTGCTGCTCTGAGGACACTCCCACCA CGGCTCCATTAGTTAAGGATAACTGTGCCAAGTCTTGCTACTCCCTCGAAAAGCCCGATGTCAGCTGCCCCGGAT CTTGCTGTCCCAGAGACCAGCGTGTCAAAGACAATAACACCAAGAGCGTTTATGCGGACCTATGCTGTTCGAAGG TCGGATCCGTTGTTGAACCTCTAACTAGTGGGTGTGCAGGGTCTTTTTGTGGAACAGCTAAGAACACGATTAGCA AACAGCTACCTAACGCCGCCTCCTCTGGCTCTTGCTGTAAGCCACCGAAGCAGGATATCGTTAGTTGCGCAGATT CTCGCTGCACAGAAAAGCAGCCGGCCAACCCCCAAGGCTCTTGCACTGATGCTTGCTGCTCTTCTGCTGTGCCCG ACCCTGGTTTAGAGATTGAGGAAGCCTCGATTCAGGCTATCACCGACATAGAGAATCAGAGTACCGGCAAGGAAC ATGTTGTCCTCAGCATTTCTGGCATGACTTGTACTGGTTGCGAGACAAAGCTTAGCCGAACCTTGGATACTCTCC CCGCCGTCAAAGACCTGAAAACCAGTCTGGTTCTCTCACGAGCCGAGTTCAACATTGATCTGCGCCTTAGCTCAG TTGAGGAAGTCATGAAACATCTGGAGCGAACCACTGAATTTAAGTGCAAAAGAGTCCAGAACCAGGGATCTAGCC TAGATCTTATTGTCCCTGATGAGCCCTCGAATTTCATTAGTCAGACGTGGCCGGACGGAGTTCTCGACATGGCAC CTGTAGACAAGCAGACTGTGCGAGTTGCGTTTGATCCGAATATCGTGGGAGCTCGAGAACTCTCCAAGATTTGGG GTCCGCCAATTGAACTTGCTCCTCCACGTGGCGACCCTTCGCTGGAGGCTGGCAGCAAGCATGTTCGTCATGTCG GATACATGACGCTTCTCTCCGCTGTCTTAACGATTCCGGTCCTAGTCATGGCATGGGCTTCGCTTCCTGACGGGG AGGTGGCATATTCATCGGCTTCACTCACATTGGCCACGATTGTTCAAGTTGTCATAGCAGGGCCTTTCTATCCTA AGGCCCTGAAGGCTCTCATTTTCTCGAGGGTTATCGAGATGGACCTCTTGATCGTCTTGAGCACCAGTGCTGCCT ACATATTCTCGGTGGTCTCCTTTGGGTACCTCATTGCAGAGCAGCCCCTTTCGACTGGTCAATTCTTTGAAACGA GCACTCTCTTAGTCACCTTGATCATGGTTGGTCGATGGGTTGCCGCTCTCGCTCGTCAGAGAGCTGTTGAATCTA TTTCTATCCGGTCACTTCAGGCATCGACAGCTATCCTTGTCGACCAAAAGAGCGGAACGGAACGTGAGATTGACG CCCGACTTCTTCAATACGGCGACACCTTCAAAGTTCTCCCTGACACCAGAATCCCGACAGACGGCACTGTCATCA ATGGGTCGTCTGAGGTTGACGAGTCTATGCTCACTGGTGAATCTAGACCAGTAGAGAAATATCCCAAGTCTGTGG TGGTTGCTGGGTCTGTCAATGGCTCTGGAGTTATGACTGTTCGACTGAACCGCTTGCCTAGCGATAACACTATCA ATGCCATTGCTGCGATGGTCGATGAGGCCAAACTGTCGAAACCTAAGCTGCAGGATCTCGCAGACCGGGTAGCGT CCTACTTCGTCCCGGTTGTGCTGGCATTGACAATCATCACGTTCGTCATCTGGGTTGCAGTAGGCATGACTGTTC GTGGATATGATGGATCCGAAGCTACAATTCAGGCCATCACCTATGCCATTACTGTCCTCATTGTTTCTTGCCCCT GCGCCATTGGACTGGCTGTTCCTATGGTCATTGTGATTGCCAGCGGAGTCGCGGCGGAAAGAGGTATCATCTTCA AGTCATCAGATGCTATTGAAGTGGCTCATAAGACGTCGCACGTCGTGTTTGACAAGACTGGGACCTTGACTCGGG GAAAGCTTTCTGTCGTAACGACGGAGTGCGCCAACGTGGACAAGCTCCCGCTTCTTCTAGGCCTCATCGAGAACA ACCGACATCCAGTCTCAGTTTCTGTGGCTGCTCACCTCAAGGATGCCGGAGTTACGGCTTCGACTGTTCCTGAGC CCAAGAGCCTTACTGGCAAAGGTGTTGAAACCACCTTTGGTGGCCGGAAACTTCGAGCAGGCAATTCTCGCTGGC TGAATTTATCGGAAAATGAAGTTGTTCAGCCAATGCTTGCTCAAGGGTACACTGTCTTCTGCTTTACTATCGACA ATGCGTTACAGGCGGTCTATGGTCTTGAAGATGAGCTTCGACCTGACGCTGCGGGAACGATTGAGACCTTACACA GGCGTGGCGTCTCGGTACATGTCGTTTCTGGCGACGATGACGGAGCTGTTCGGTCTTTGGCGTCCAAGCTTAGCA TTCCTGGCGGTCAAGTGCGTTCTCGAAGCTCGCCCGCCGACAAGAAGGACTATATCCAGACACTCCTCCGTACTC GCATAGATCGTAAGGAACCGGTTGTTGTTTTCTGCGGTGACGGCACGAACGATGCTGTTGCTCTCGCACAGGCTA CGATTGGCGTCCACATGAACGAAGGCACAGATGTCGCGCAATCCGCCGCGGACGTGGTTCTCATGCGGCCTTTTC TGGCTGGTATCCCCACCATGATGGACGCCAGTCGGAAATCTGTCAACCGCATCAAGTTCAACTTTATATGGAGCT TCGTATACAATACCTTTGCAGTCCTTCTCGCTGCGGGTGCTTTTGTCAATGCCAGAATTCCCCCAGAGTTTGCGG GACTGGGAGAGTTGGTGAGTGTGTTGCCAGTCATTGCTGCTGCGCTGCTTCTGCGCTGGTCGAAGTTCTAG