Fungal Genomics

Agaricus bisporus var bisporus H39 Agaricus bisporus var bisporus H97 Agaricus bisporus var burnettii H119p4 Aspergillus niger CBS 112.32 Aspergillus niger CBS 113.50 Aspergillus niger CBS 115988 Aspergillus niger CBS 115989 Aspergillus niger CBS 118.52 Aspergillus niger CBS 124.48 Aspergillus niger CBS 131.52 Aspergillus niger CBS 133816 Aspergillus niger CBS 147320 Aspergillus niger CBS 147321 Aspergillus niger CBS 147322 Aspergillus niger CBS 147323 Aspergillus niger CBS 147324 Aspergillus niger CBS 147343 Aspergillus niger CBS 147344 Aspergillus niger CBS 147345 Aspergillus niger CBS 147346 Aspergillus niger CBS 147347 Aspergillus niger CBS 147352 Aspergillus niger CBS 147353 Aspergillus niger CBS 147371 Aspergillus niger CBS 147482 Aspergillus niger CBS 630.78 Aspergillus niger CBS 769.97 Niveomyces coronatus CBS 149186 Ophiocordyceps australis 1348a (Ghana) Ophiocordyceps australis map64 (Brazil) Ophiocordyceps camponoti-floridani Ophiocordyceps camponoti-rufipedis Ophiocordyceps kimflemingae Ophiocordyceps subramaniannii Penicillium roqueforti DTO002I6 Penicillium roqueforti DTO003C3 Penicillium roqueforti DTO003H1 (CBS 147308) Penicillium roqueforti DTO006G1 Penicillium roqueforti DTO006G7 Penicillium roqueforti DTO012A1 Penicillium roqueforti DTO012A2 (CBS 147309) Penicillium roqueforti DTO012A6 (CBS 147310) Penicillium roqueforti DTO012A7 Penicillium roqueforti DTO012A8 Penicillium roqueforti DTO012A9 Penicillium roqueforti DTO013E5 Penicillium roqueforti DTO013F2 Penicillium roqueforti DTO013F5 (CBS 147311) Penicillium roqueforti DTO027I6 Penicillium roqueforti DTO032C6 Penicillium roqueforti DTO039G3 Penicillium roqueforti DTO046C5 Penicillium roqueforti DTO070G2 (CBS 147317) Penicillium roqueforti DTO081F9 (CBS 147318) Penicillium roqueforti DTO101D6 (CBS 147325) Penicillium roqueforti DTO102I9 (CBS 147326) Penicillium roqueforti DTO126G2 (CBS 147330) Penicillium roqueforti DTO127F7 (CBS 147331) Penicillium roqueforti DTO127F9 (CBS 147332) Penicillium roqueforti DTO130C1 (CBS 147333) Penicillium roqueforti DTO163C3 (CBS 147337) Penicillium roqueforti DTO163F5 (CBS 147338) Penicillium roqueforti DTO163G4 (CBS 147339) Penicillium roqueforti DTO265D5 (CBS 147372) Penicillium roqueforti DTO369A1 (CBS 147354) Penicillium roqueforti DTO375B1 (CBS 147355) Penicillium roqueforti DTO377G2 (LCP 96.3914a) Penicillium roqueforti LCP96 04111 Rhodonia placenta FPRL280 Torrubiellomyces zombiae CBS 149187

General Properties

Protein ID	Pro_DTO377G3_2|g3199.t1
Gene name
Location	scaffold_04:952555..956244
Strand	-
Gene length (bp)	3689
Transcript length (bp)	3312
Coding sequence length (bp)	3312
Protein length (aa)	1104

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PFAM Domains

PFAM Domain ID	Short name	Long name	E-value	Start	End
PF01644	Chitin_synth_1	Chitin synthase	2.4E-77	379	541
PF08407	Chitin_synth_1N	Chitin synthase N-terminal	1.0E-25	306	378
PF03142	Chitin_synth_2	Chitin synthase	7.2E-20	519	693

GO

GO Term	Description	Terminal node
GO:0006031	chitin biosynthetic process	Yes
GO:0004100	chitin synthase activity	Yes
GO:1901073	glucosamine-containing compound biosynthetic process	No
GO:0043170	macromolecule metabolic process	No
GO:0046349	amino sugar biosynthetic process	No
GO:0008194	UDP-glycosyltransferase activity	No
GO:0016758	hexosyltransferase activity	No
GO:1901566	organonitrogen compound biosynthetic process	No
GO:0016757	glycosyltransferase activity	No
GO:0008150	biological_process	No
GO:0071704	organic substance metabolic process	No
GO:0016740	transferase activity	No
GO:0008152	metabolic process	No
GO:1901071	glucosamine-containing compound metabolic process	No
GO:0003824	catalytic activity	No
GO:0009058	biosynthetic process	No
GO:0003674	molecular_function	No
GO:0006807	nitrogen compound metabolic process	No
GO:0006040	amino sugar metabolic process	No
GO:0006030	chitin metabolic process	No
GO:0008375	acetylglucosaminyltransferase activity	No
GO:1901137	carbohydrate derivative biosynthetic process	No
GO:0006022	aminoglycan metabolic process	No
GO:1901135	carbohydrate derivative metabolic process	No
GO:1901564	organonitrogen compound metabolic process	No
GO:0009059	macromolecule biosynthetic process	No
GO:1901576	organic substance biosynthetic process	No
GO:0006023	aminoglycan biosynthetic process	No

SignalP

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SignalP signal predicted	Location (based on Ymax)	D score (significance: > 0.45)
No	1 - 14	0.45

Transmembrane Domains

Domain #	Start	End	Length
1	723	745	22
2	766	788	22
3	798	820	22
4	841	863	22
5	873	892	19
6	972	994	22
7	999	1021	22

Transcription Factor Class

(None)

Expression data

Analysis 1: Genome-wide gene expression in conidia of Penicillium roqueforti during growth at various temperatures and for various amounts of time. Published in Punt et al., 2020.

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Sequences

Type of sequence	Sequence
Locus	Download genbank file of locus The gene with 5 kb flanks (if sufficient flanking sequence is available). For use in cloning design programs. NOTE: features (genes or exons) that are only partially contained within the sequence are completely excluded.
Protein	>Pro_DTO377G3_2|g3199.t1 MNRHPPSEYGDAPPAYLNHDASSYLSDPDSPTNASRLNGGTMRLLPSGDGVDDSGISHMPSHYDPDYDHTPGFPR DGATCTAKSDSFIDGTERLGASSNCPSMGIATRTEPTPSFLAVPSVASPSRPPSSLSSVPSIPPPTANLADTSVY PSIPPRTGSPIRPWSPSHIRPPSVSSVGYERADLNGSPRPGTPSSRYGGSPRRPLPPAPLFTGPKSTMDTSIDIG DAHGEDPFGGDGRTINHTSRASVRSFMSESTMLGDEKDGMSKVDLDDDYDDESHVLDPNLHYGPAPDKQGRRGVR SKQVAKKEVQLVNGELILECKIPTILHSFLPRRDEREFTHMRYTAVTTDPDDYGERGYKLRQQIGTTTRETELFI CITMYNEDEIGFTRTMHGVMQNISHFCSRTKSRTWGRDGWKKIVVCIVADGRKKVHPRTLNALAALGVYQEGIAK NIVNQKEVQAHVYEYTTQVSLDDDLKFKGAEKGIVPCQVIFCLKEHNKKKLNSHRWFFNAFGRALQPNICILLDV GTRPEPMALYHLWKAFDQDSNVAGAAGEIKAAKGKNMLGLLNPLVASQNFEYKMSNILDKPLESVFGYITVLPGA LSAYRFFALQNDADGHGPLNQYFKGETLHGQDADVFTANMYLAEDRILCWELVAKREERWVLKFVKNAVGETDVP DSVPEFISQRRRWLNGAFFAAVYSIFNAKQIWKTDHTFTRKVLLHIEFFYQFLNLLFTYFGLANFYLAFYFIAGS LTDEKLDPFGHNMGKYIFIVLRYACVLVMCLQFIISLGNRPQGAKNLYLSGIIVYAIIMFYTVFCALYLVVKELL ARAGVGNDDLEVGDSLMMNIVISMLSTVGLYFYSSFLYLDPWHMFTSSVQYFLLMPSYICILQVYAFCNTHDVTW GTKGDNVINTDLGAAKTINGSTVVIEMPSEQLDIDSGYDAALRNLRDRLEVPEPPPSDTQLQEDYYRAVRTYMVS IWMVANVILAMAVSEIYGVDSGGTNIYLAIILWSVAVLAAIRAVGSTAYAILNVVQKIVEGKTKFDAGNMTNFAP SSFGGSSATATSESGAASSRPVRYGGGVSFKDKLAEARWAAGRTVGKAMFWRK*
Coding	>Pro_DTO377G3_2|g3199.t1 ATGAACCGCCATCCGCCATCCGAATACGGCGACGCGCCGCCCGCATACCTCAACCATGACGCAAGTTCCTATCTG TCCGATCCTGACTCTCCGACCAATGCCTCACGTCTGAATGGAGGAACGATGCGCTTGTTGCCAAGCGGCGACGGT GTCGATGATTCAGGTATCAGTCATATGCCCTCCCATTATGACCCAGATTATGATCACACTCCTGGTTTCCCTCGC GATGGAGCCACGTGCACTGCCAAATCCGACTCCTTCATTGACGGGACGGAGAGGCTGGGAGCCTCGAGCAATTGC CCGTCAATGGGCATTGCTACAAGGACCGAGCCAACTCCTTCCTTCCTTGCTGTGCCTAGCGTCGCTTCACCTTCG CGTCCACCATCCAGCTTGTCCAGTGTACCCAGTATCCCGCCTCCCACAGCAAACCTCGCAGACACTTCTGTCTAC CCATCTATTCCCCCACGCACAGGATCGCCAATTCGCCCATGGAGCCCATCCCACATCCGACCACCCTCCGTGTCA AGTGTTGGATATGAGCGCGCCGATTTAAACGGTAGTCCAAGGCCCGGTACACCCAGCTCAAGATATGGGGGTAGT CCCCGTCGACCATTGCCTCCTGCGCCGTTGTTCACTGGACCAAAATCAACAATGGATACGAGCATCGATATTGGT GATGCCCATGGCGAAGATCCATTCGGTGGTGATGGCCGCACAATTAACCACACCTCACGCGCCAGTGTCCGATCA TTCATGAGCGAATCGACAATGTTGGGAGACGAGAAAGATGGCATGTCCAAAGTCGATCTCGATGATGATTATGAC GACGAATCGCACGTTTTGGATCCCAACCTCCACTATGGCCCAGCACCCGACAAGCAGGGCCGTCGTGGTGTCCGA TCCAAGCAGGTCGCCAAAAAAGAAGTTCAGTTGGTCAATGGAGAGCTTATTTTGGAGTGCAAAATTCCCACCATT CTTCACAGCTTCCTCCCTCGCCGCGATGAGCGTGAGTTCACGCACATGCGATATACCGCTGTTACAACCGATCCG GACGACTATGGCGAACGTGGATATAAGCTTCGGCAGCAGATTGGTACCACGACTCGCGAGACAGAGCTGTTTATT TGTATTACCATGTACAACGAAGACGAGATTGGTTTCACCCGTACTATGCATGGCGTTATGCAGAATATCAGCCAC TTCTGCTCGCGCACCAAGTCGCGTACTTGGGGCCGCGATGGATGGAAGAAAATCGTTGTTTGCATTGTGGCTGAT GGACGTAAGAAGGTCCACCCGCGCACACTCAATGCATTGGCCGCCCTGGGTGTTTACCAGGAGGGTATTGCGAAG AATATTGTCAACCAAAAGGAAGTTCAGGCACACGTGTACGAGTACACCACGCAGGTCTCGCTTGATGATGATCTC AAGTTTAAGGGTGCGGAGAAGGGAATTGTTCCGTGTCAGGTTATCTTCTGTTTGAAGGAACACAACAAGAAGAAG CTGAACTCCCACAGATGGTTTTTCAATGCCTTTGGTCGTGCCCTTCAGCCTAACATTTGTATTTTGCTCGATGTT GGAACTCGACCAGAGCCAATGGCGCTCTACCACTTGTGGAAGGCGTTTGATCAGGACTCCAATGTTGCCGGCGCT GCTGGAGAGATCAAGGCTGCTAAAGGTAAGAACATGCTCGGTCTGCTCAACCCTCTGGTGGCAAGTCAGAACTTC GAATACAAAATGTCCAATATTCTCGACAAGCCGCTGGAATCAGTCTTCGGTTACATCACTGTGTTGCCCGGTGCG CTCAGCGCATATCGATTCTTTGCGCTGCAAAACGACGCAGACGGACATGGCCCCCTGAACCAATATTTCAAGGGT GAAACACTCCACGGTCAAGATGCAGACGTTTTCACTGCCAACATGTATCTCGCCGAAGATCGTATTCTTTGCTGG GAGTTGGTCGCCAAACGGGAAGAGAGATGGGTATTGAAGTTTGTTAAGAACGCCGTTGGAGAAACCGATGTGCCG GACTCGGTTCCTGAGTTCATCTCCCAGCGTCGAAGATGGCTGAACGGTGCGTTCTTCGCGGCTGTTTACTCGATT TTCAATGCCAAACAGATCTGGAAGACCGATCATACTTTTACCCGGAAGGTCTTGCTTCACATCGAGTTCTTTTAT CAATTCCTTAATTTGCTGTTTACTTACTTTGGTCTTGCCAATTTCTACCTCGCTTTCTATTTCATTGCTGGCTCT TTAACCGATGAGAAACTTGACCCATTTGGTCACAACATGGGCAAATATATCTTCATTGTTCTGCGCTATGCCTGT GTCCTGGTTATGTGTTTGCAGTTTATTATCTCGCTGGGTAATCGACCGCAAGGTGCCAAGAATCTCTATCTCTCT GGTATCATTGTGTACGCCATTATCATGTTCTACACGGTCTTCTGCGCCCTCTACTTGGTGGTCAAAGAGTTACTC GCACGTGCTGGGGTTGGAAACGATGACCTAGAAGTTGGCGATAGCCTAATGATGAACATTGTGATTTCCATGTTG TCAACTGTCGGTCTCTACTTCTACAGCTCATTCCTCTACCTGGACCCGTGGCACATGTTCACCTCTTCGGTCCAA TACTTTTTGCTCATGCCCAGCTACATCTGCATTCTCCAAGTCTACGCCTTCTGCAACACCCACGACGTCACTTGG GGAACCAAAGGTGACAACGTAATCAACACCGATCTCGGTGCAGCAAAGACCATCAACGGCTCAACCGTCGTCATC GAAATGCCCTCCGAACAACTCGATATTGACTCCGGCTACGACGCGGCCCTCCGCAACCTCCGCGATCGCCTCGAG GTCCCCGAGCCCCCGCCATCGGATACCCAGTTGCAGGAGGACTACTATCGTGCTGTCCGTACTTACATGGTCTCC ATCTGGATGGTCGCAAACGTAATCCTCGCCATGGCTGTGTCCGAAATCTACGGTGTTGACTCCGGCGGCACAAAC ATCTATCTCGCTATCATCTTGTGGTCTGTCGCTGTCCTCGCGGCTATTCGTGCTGTTGGCTCTACTGCTTATGCT ATCTTGAACGTCGTTCAAAAAATCGTTGAAGGAAAGACGAAGTTCGATGCGGGTAATATGACGAACTTCGCTCCT AGTTCTTTCGGCGGTTCGAGTGCGACTGCTACTTCTGAGTCTGGAGCGGCCTCCTCCCGCCCTGTGCGCTACGGC GGCGGTGTGTCCTTCAAGGATAAGCTAGCCGAAGCTCGCTGGGCTGCTGGCAGGACCGTTGGAAAAGCTATGTTC TGGCGGAAGTAG
Transcript	>Pro_DTO377G3_2|g3199.t1 ATGAACCGCCATCCGCCATCCGAATACGGCGACGCGCCGCCCGCATACCTCAACCATGACGCAAGTTCCTATCTG TCCGATCCTGACTCTCCGACCAATGCCTCACGTCTGAATGGAGGAACGATGCGCTTGTTGCCAAGCGGCGACGGT GTCGATGATTCAGGTATCAGTCATATGCCCTCCCATTATGACCCAGATTATGATCACACTCCTGGTTTCCCTCGC GATGGAGCCACGTGCACTGCCAAATCCGACTCCTTCATTGACGGGACGGAGAGGCTGGGAGCCTCGAGCAATTGC CCGTCAATGGGCATTGCTACAAGGACCGAGCCAACTCCTTCCTTCCTTGCTGTGCCTAGCGTCGCTTCACCTTCG CGTCCACCATCCAGCTTGTCCAGTGTACCCAGTATCCCGCCTCCCACAGCAAACCTCGCAGACACTTCTGTCTAC CCATCTATTCCCCCACGCACAGGATCGCCAATTCGCCCATGGAGCCCATCCCACATCCGACCACCCTCCGTGTCA AGTGTTGGATATGAGCGCGCCGATTTAAACGGTAGTCCAAGGCCCGGTACACCCAGCTCAAGATATGGGGGTAGT CCCCGTCGACCATTGCCTCCTGCGCCGTTGTTCACTGGACCAAAATCAACAATGGATACGAGCATCGATATTGGT GATGCCCATGGCGAAGATCCATTCGGTGGTGATGGCCGCACAATTAACCACACCTCACGCGCCAGTGTCCGATCA TTCATGAGCGAATCGACAATGTTGGGAGACGAGAAAGATGGCATGTCCAAAGTCGATCTCGATGATGATTATGAC GACGAATCGCACGTTTTGGATCCCAACCTCCACTATGGCCCAGCACCCGACAAGCAGGGCCGTCGTGGTGTCCGA TCCAAGCAGGTCGCCAAAAAAGAAGTTCAGTTGGTCAATGGAGAGCTTATTTTGGAGTGCAAAATTCCCACCATT CTTCACAGCTTCCTCCCTCGCCGCGATGAGCGTGAGTTCACGCACATGCGATATACCGCTGTTACAACCGATCCG GACGACTATGGCGAACGTGGATATAAGCTTCGGCAGCAGATTGGTACCACGACTCGCGAGACAGAGCTGTTTATT TGTATTACCATGTACAACGAAGACGAGATTGGTTTCACCCGTACTATGCATGGCGTTATGCAGAATATCAGCCAC TTCTGCTCGCGCACCAAGTCGCGTACTTGGGGCCGCGATGGATGGAAGAAAATCGTTGTTTGCATTGTGGCTGAT GGACGTAAGAAGGTCCACCCGCGCACACTCAATGCATTGGCCGCCCTGGGTGTTTACCAGGAGGGTATTGCGAAG AATATTGTCAACCAAAAGGAAGTTCAGGCACACGTGTACGAGTACACCACGCAGGTCTCGCTTGATGATGATCTC AAGTTTAAGGGTGCGGAGAAGGGAATTGTTCCGTGTCAGGTTATCTTCTGTTTGAAGGAACACAACAAGAAGAAG CTGAACTCCCACAGATGGTTTTTCAATGCCTTTGGTCGTGCCCTTCAGCCTAACATTTGTATTTTGCTCGATGTT GGAACTCGACCAGAGCCAATGGCGCTCTACCACTTGTGGAAGGCGTTTGATCAGGACTCCAATGTTGCCGGCGCT GCTGGAGAGATCAAGGCTGCTAAAGGTAAGAACATGCTCGGTCTGCTCAACCCTCTGGTGGCAAGTCAGAACTTC GAATACAAAATGTCCAATATTCTCGACAAGCCGCTGGAATCAGTCTTCGGTTACATCACTGTGTTGCCCGGTGCG CTCAGCGCATATCGATTCTTTGCGCTGCAAAACGACGCAGACGGACATGGCCCCCTGAACCAATATTTCAAGGGT GAAACACTCCACGGTCAAGATGCAGACGTTTTCACTGCCAACATGTATCTCGCCGAAGATCGTATTCTTTGCTGG GAGTTGGTCGCCAAACGGGAAGAGAGATGGGTATTGAAGTTTGTTAAGAACGCCGTTGGAGAAACCGATGTGCCG GACTCGGTTCCTGAGTTCATCTCCCAGCGTCGAAGATGGCTGAACGGTGCGTTCTTCGCGGCTGTTTACTCGATT TTCAATGCCAAACAGATCTGGAAGACCGATCATACTTTTACCCGGAAGGTCTTGCTTCACATCGAGTTCTTTTAT CAATTCCTTAATTTGCTGTTTACTTACTTTGGTCTTGCCAATTTCTACCTCGCTTTCTATTTCATTGCTGGCTCT TTAACCGATGAGAAACTTGACCCATTTGGTCACAACATGGGCAAATATATCTTCATTGTTCTGCGCTATGCCTGT GTCCTGGTTATGTGTTTGCAGTTTATTATCTCGCTGGGTAATCGACCGCAAGGTGCCAAGAATCTCTATCTCTCT GGTATCATTGTGTACGCCATTATCATGTTCTACACGGTCTTCTGCGCCCTCTACTTGGTGGTCAAAGAGTTACTC GCACGTGCTGGGGTTGGAAACGATGACCTAGAAGTTGGCGATAGCCTAATGATGAACATTGTGATTTCCATGTTG TCAACTGTCGGTCTCTACTTCTACAGCTCATTCCTCTACCTGGACCCGTGGCACATGTTCACCTCTTCGGTCCAA TACTTTTTGCTCATGCCCAGCTACATCTGCATTCTCCAAGTCTACGCCTTCTGCAACACCCACGACGTCACTTGG GGAACCAAAGGTGACAACGTAATCAACACCGATCTCGGTGCAGCAAAGACCATCAACGGCTCAACCGTCGTCATC GAAATGCCCTCCGAACAACTCGATATTGACTCCGGCTACGACGCGGCCCTCCGCAACCTCCGCGATCGCCTCGAG GTCCCCGAGCCCCCGCCATCGGATACCCAGTTGCAGGAGGACTACTATCGTGCTGTCCGTACTTACATGGTCTCC ATCTGGATGGTCGCAAACGTAATCCTCGCCATGGCTGTGTCCGAAATCTACGGTGTTGACTCCGGCGGCACAAAC ATCTATCTCGCTATCATCTTGTGGTCTGTCGCTGTCCTCGCGGCTATTCGTGCTGTTGGCTCTACTGCTTATGCT ATCTTGAACGTCGTTCAAAAAATCGTTGAAGGAAAGACGAAGTTCGATGCGGGTAATATGACGAACTTCGCTCCT AGTTCTTTCGGCGGTTCGAGTGCGACTGCTACTTCTGAGTCTGGAGCGGCCTCCTCCCGCCCTGTGCGCTACGGC GGCGGTGTGTCCTTCAAGGATAAGCTAGCCGAAGCTCGCTGGGCTGCTGGCAGGACCGTTGGAAAAGCTATGTTC TGGCGGAAGTAG
Gene	>Pro_DTO377G3_2|g3199.t1 ATGAACCGCCATCCGCCATCCGAATACGGCGACGCGCCGCCCGCATACCTCAACCATGACGCAAGTTCCTATCTG TCCGATCCTGACTCTCCGACCAATGCCTCACGTCTGAATGGAGGAACGATGCGCTTGTTGCCAAGCGGCGACGGT GTCGATGATTCAGGTATCAGTCATATGCCCTCCCATTATGACCCAGATTATGATCACACTCCGTATGTACTTCCC TATACTTCCCAATTGTCTCTGATGCAACCCTGTCCGTCTTCACATTCCAGTGGTTTCCCTCGCGATGGAGCCACG TGCACTGCCAAATCCGACTCCTTCATTGACGGGACGGAGAGGCTGGGAGCCTCGAGCAATTGCCCGTCAATGGGC ATTGCTACAAGGACCGAGCCAACTCCTTCCTTCCTTGCTGTTTGTCAATCACCCACCCTGTAAACATTGTAAACA TTGTACACTTGATACTAGTGCATTGTTTACTGTCCCAACCCCCCTCCACCTCCACATTGGGCCTCTTAGTGCCAG CTTCGCGGCAAAATGGAACGTCTTCCAAGACCAAGGTCTAACACCAGGGCGCACAATTATAGGACCGGACATGAT CGAAGCTATGATAGTTATTACCAGGTGCCTAGCGTCGCTTCACCTTCGCGTCCACCATCCAGCTTGTCCAGTGTA CCCAGTATCCCGCCTCCCACAGCAAACCTCGCAGACACTTCTGTCTACCCATCTATTCCCCCACGCACAGGATCG CCAATTCGCCCATGGAGCCCATCCCACATCCGACCACCCTCCGTGTCAAGTGTTGGATATGAGCGCGCCGATTTA AACGGTAGTCCAAGGCCCGGTACACCCAGCTCAAGATATGGGGGTAGTCCCCGTCGACCATTGCCTCCTGCGCCG TTGTTCACTGGACCAAAATCAACAATGGATACGAGCATCGATATTGGTGATGCCCATGGCGAAGATCCATTCGGT GGTGATGGCCGCACAATTAACCACACCTCACGCGCCAGTGTCCGATCATTCATGAGCGAATCGACAATGTTGGGA GACGAGAAAGATGGCATGTCCAAAGTCGATCTCGATGATGATTATGACGACGAATCGCACGTTTTGGATCCCAAC CTCCACTATGGCCCAGCACCCGACAAGCAGGGCCGTCGTGGTGTCCGATCCAAGCAGGTCGCCAAAAAAGAAGTT CAGTTGGTCAATGGAGAGCTTATTTTGGAGTGCAAAATTCCCACCATTCTTCACAGCTTCCTCCCTCGCCGCGAT GAGCGTGAGTTCACGCACATGCGATATACCGCTGTTACAACCGATCCGGACGACTATGGCGAACGTGGATATAAG CTTCGGCAGCAGATTGGTACCACGACTCGCGAGACAGAGCTGTTTATTTGTATTACCATGTACAACGAAGACGAG ATTGGTTTCACCCGTACTATGCATGGCGTTATGCAGAATATCAGCCACTTCTGCTCGCGCACCAAGTCGCGTACT TGGGGCCGCGATGGATGGAAGAAAATCGTTGTTTGCATTGTGGCTGATGGACGTAAGAAGGTCCACCCGCGCACA CTCAATGCATTGGCCGCCCTGGGTGTTTACCAGGAGGGTATTGCGAAGAATATTGTCAACCAAAAGGAAGTTCAG GCACACGTGTACGAGTACACCACGCAGGTCTCGCTTGATGATGATCTCAAGTTTAAGGGTGCGGAGAAGGGAATT GTTCCGTGTCAGGTTATCTTCTGTTTGAAGGAACACAACAAGAAGAAGCTGAACTCCCACAGATGGTTTTTCAAT GCCTTTGGTCGTGCCCTTCAGCCTAACATTTGTATTTTGCTCGATGTTGGAACTCGACCAGAGCCAATGGCGCTC TACCACTTGTGGAAGGCGTTTGATCAGGACTCCAATGTTGCCGGCGCTGCTGGAGAGATCAAGGCTGCTAAAGGT AAGAACATGCTCGGTCTGCTCAACCCTCTGGTGGCAAGTCAGAACTTCGAATACAAAATGTCCAATATTCTCGAC AAGCCGCTGGAATCAGTCTTCGGTTACATCACTGTGTTGCCCGGTGCGCTCAGCGCATATCGATTCTTTGCGCTG CAAAACGACGCAGACGGACATGGCCCCCTGAACCAATATTTCAAGGGTGAAACACTCCACGGTCAAGATGCAGAC GTTTTCACTGCCAACATGTATCTCGCCGAAGATCGTATTCTTTGCTGGGAGTTGGTCGCCAAACGGGAAGAGAGA TGGGTATTGAAGTTTGTTAAGAACGCCGTTGGAGAAACCGATGTGCCGGACTCGGTTCCTGAGTTCATCTCCCAG CGTCGAAGATGGCTGAACGGTGCGTTCTTCGCGGCTGTTTACTCGATTTTCAATGCCAAACAGATCTGGAAGACC GATCATACTTTTACCCGGAAGGTCTTGCTTCACATCGAGTTCTTTTATCAATTCCTTAATTTGCTGTTTACTTAC TTTGGTCTTGTGAGTTTTGCGCTCTGTTTTCTTTGGGGGCGTCCACTGACTTTCACAGGCCAATTTCTACCTCGC TTTCTATTTCATTGCTGGCTCTTTAACCGATGAGAAACTTGACCCATTTGGTCACAACATGGGCAAATATATCTT CATTGTTCTGCGCTATGCCTGTGTCCTGGTTATGTGTTTGCAGTTTATTATCTCGCTGGGTAATCGACCGCAAGG GTGAGTCCAAAATGCTTCGTCATATATTCGAACTTGACTGACATTCTCTTTTCAGTGCCAAGAATCTCTATCTCT CTGGTATCATTGTGTACGCCATTATCATGTTCTACACGGTCTTCTGCGCCCTCTACTTGGTGGTCAAAGAGTTAC TCGCACGTGCTGGGGTTGGAAACGATGACCTAGAAGTTGGCGATAGCCTAATGATGAACATTGTGATTTCCATGT TGTCAACTGTCGGTCTCTACTTCTACAGCTCATTCCTCTACCTGGACCCGTGGCACATGTTCACCTCTTCGGTCC AATACTTTTTGCTCATGCCCAGCTACATCTGCATTCTCCAAGTCTACGCCTTCTGCAACACCCACGACGTCACTT GGGGAACCAAAGGTGACAACGTAATCAACACCGATCTCGGTGCAGCAAAGACCATCAACGGCTCAACCGTCGTCA TCGAAATGCCCTCCGAACAACTCGATATTGACTCCGGCTACGACGCGGCCCTCCGCAACCTCCGCGATCGCCTCG AGGTCCCCGAGCCCCCGCCATCGGATACCCAGTTGCAGGAGGACTACTATCGTGCTGTCCGTACTTACATGGTCT CCATCTGGATGGTCGCAAACGTAATCCTCGCCATGGCTGTGTCCGAAATCTACGGTGTTGACTCCGGCGGCACAA ACATCTATCTCGCTATCATCTTGTGGTCTGTCGCTGTCCTCGCGGCTATTCGTGCTGTTGGCTCTACTGCTTATG CTATCTTGAACGTCGTTCAAAAAATCGTTGAAGGAAAGACGAAGTTCGATGCGGGTAATATGACGAACTTCGCTC CTAGTTCTTTCGGCGGTTCGAGTGCGACTGCTACTTCTGAGTCTGGAGCGGCCTCCTCCCGCCCTGTGCGCTACG GCGGCGGTGTGTCCTTCAAGGATAAGCTAGCCGAAGCTCGCTGGGCTGCTGGCAGGACCGTTGGAAAAGCTATGT TCTGGCGGAAGTAG