Fungal Genomics

Agaricus bisporus var bisporus H39 Agaricus bisporus var bisporus H97 Agaricus bisporus var burnettii H119p4 Aspergillus niger CBS 112.32 Aspergillus niger CBS 113.50 Aspergillus niger CBS 115988 Aspergillus niger CBS 115989 Aspergillus niger CBS 118.52 Aspergillus niger CBS 124.48 Aspergillus niger CBS 131.52 Aspergillus niger CBS 133816 Aspergillus niger CBS 147320 Aspergillus niger CBS 147321 Aspergillus niger CBS 147322 Aspergillus niger CBS 147323 Aspergillus niger CBS 147324 Aspergillus niger CBS 147343 Aspergillus niger CBS 147344 Aspergillus niger CBS 147345 Aspergillus niger CBS 147346 Aspergillus niger CBS 147347 Aspergillus niger CBS 147352 Aspergillus niger CBS 147353 Aspergillus niger CBS 147371 Aspergillus niger CBS 147482 Aspergillus niger CBS 630.78 Aspergillus niger CBS 769.97 Niveomyces coronatus CBS 149186 Ophiocordyceps australis 1348a (Ghana) Ophiocordyceps australis map64 (Brazil) Ophiocordyceps camponoti-floridani Ophiocordyceps camponoti-rufipedis Ophiocordyceps kimflemingae Ophiocordyceps subramaniannii Penicillium roqueforti DTO002I6 Penicillium roqueforti DTO003C3 Penicillium roqueforti DTO003H1 (CBS 147308) Penicillium roqueforti DTO006G1 Penicillium roqueforti DTO006G7 Penicillium roqueforti DTO012A1 Penicillium roqueforti DTO012A2 (CBS 147309) Penicillium roqueforti DTO012A6 (CBS 147310) Penicillium roqueforti DTO012A7 Penicillium roqueforti DTO012A8 Penicillium roqueforti DTO012A9 Penicillium roqueforti DTO013E5 Penicillium roqueforti DTO013F2 Penicillium roqueforti DTO013F5 (CBS 147311) Penicillium roqueforti DTO027I6 Penicillium roqueforti DTO032C6 Penicillium roqueforti DTO039G3 Penicillium roqueforti DTO046C5 Penicillium roqueforti DTO070G2 (CBS 147317) Penicillium roqueforti DTO081F9 (CBS 147318) Penicillium roqueforti DTO101D6 (CBS 147325) Penicillium roqueforti DTO102I9 (CBS 147326) Penicillium roqueforti DTO126G2 (CBS 147330) Penicillium roqueforti DTO127F7 (CBS 147331) Penicillium roqueforti DTO127F9 (CBS 147332) Penicillium roqueforti DTO130C1 (CBS 147333) Penicillium roqueforti DTO163C3 (CBS 147337) Penicillium roqueforti DTO163F5 (CBS 147338) Penicillium roqueforti DTO163G4 (CBS 147339) Penicillium roqueforti DTO265D5 (CBS 147372) Penicillium roqueforti DTO369A1 (CBS 147354) Penicillium roqueforti DTO375B1 (CBS 147355) Penicillium roqueforti DTO377G2 (LCP 96.3914a) Penicillium roqueforti LCP96 04111 Rhodonia placenta FPRL280 Torrubiellomyces zombiae CBS 149187

General Properties

Protein ID	Pro_DTO377G3_2|g2871.t1
Gene name
Location	scaffold_04:88665..91970
Strand	+
Gene length (bp)	3305
Transcript length (bp)	3123
Coding sequence length (bp)	3123
Protein length (aa)	1041

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PFAM Domains

PFAM Domain ID	Short name	Long name	E-value	Start	End
PF07993	NAD_binding_4	Male sterility protein	4.9E-42	676	917
PF00501	AMP-binding	AMP-binding enzyme	1.0E-28	14	336
PF01370	Epimerase	NAD dependent epimerase/dehydratase family	7.1E-09	674	892
PF00550	PP-binding	Phosphopantetheine attachment site	4.1E-06	556	626

GO

(None)

SignalP

[Help with interpreting these statistics]

SignalP signal predicted	Location (based on Ymax)	D score (significance: > 0.45)
No	1 - 67	0.45

Transmembrane Domains

(None)

Transcription Factor Class

(None)

Expression data

Analysis 1: Genome-wide gene expression in conidia of Penicillium roqueforti during growth at various temperatures and for various amounts of time. Published in Punt et al., 2020.

Expression values

Label	Description	Expression (RPKM)	Confidence interval (low)	Confidence interval (high)
3d_25C	Three days - 25 degrees Celsius	1.54	0.42	2.66
5d_25C	Five days - 25 degrees Celsius	0.94	0.19	1.69
7d_25C	Seven days - 25 degrees Celsius	1.08	0.22	1.93
10d_25C	Ten days - 25 degrees Celsius	0.75	0.12	1.38
7d_15C	Seven days - 15 degrees Celsius	1.25	0.30	2.19
7d_30C	Seven days - 30 degrees Celsius	0.99	0.21	1.77

Differential expression

Label1	Label2	Q-value	Significant difference
3d_25C	5d_25C	0.287937	no
3d_25C	7d_25C	0.476963	no
3d_25C	7d_15C	0.693804	no
3d_25C	7d_30C	0.349054	no
3d_25C	10d_25C	0.090767	no
5d_25C	7d_25C	0.834442	no
5d_25C	7d_15C	0.595163	no
5d_25C	7d_30C	0.942722	no
5d_25C	10d_25C	0.690273	no
7d_25C	7d_15C	0.804309	no
7d_25C	7d_30C	0.897285	no
7d_25C	10d_25C	0.484220	no
7d_15C	7d_30C	0.669609	no
7d_15C	10d_25C	0.262793	no
7d_30C	10d_25C	0.616338	no

Sequences

Type of sequence	Sequence
Locus	Download genbank file of locus The gene with 5 kb flanks (if sufficient flanking sequence is available). For use in cloning design programs. NOTE: features (genes or exons) that are only partially contained within the sequence are completely excluded.
Protein	>Pro_DTO377G3_2|g2871.t1 MESFRKRLLATTIDEQAETKPTQRFAVISQGLDLSNGLRDISIKDLAQAVNFMCWWIESIIGPAHSDSPETVAYM GGNDVRYLIFFLACQKTGYQAFLPSTRNSDEAYVHLLSAINCTKFFFGEERQERVLEIHGLVPKLDIFQAPTLNT ILSDESGLRHYPYTKSYADAEDDIVCIIHSSGTTGMPKPVYLTNGFIMTFDSVTYLEKPPGRRPNTFHDLDQSQL LLAAAPFFHLMGLVTFIFSVWNECPMFVAPDKPLSVDYMIELLSTGHPTVALLPPSVLEDMSQSEKALASLKEVK KVYFAGAPLPLEIGEKLRKYTEIITVIGSSEAGVIPGLIPEDKTNWGYFEWNEDYGVEMQDTGGGVFELVIPRKK DSRDWKAVFHTYPELDAYPTNDLFTQHPTDPRLWKFCGRKDDVIVLSNGEKFNPIGMEGIIEGHPLVRKAVVVGQ SRFQAGLLVDPSPAGWDMDPKVFIEEIWPVVQAANQTIAAHGRVMKNKIRLAVKTKPFQTTPKGNVRRRMVLQDY EEEIDMIYTEDLVDDLDQSLPQTLDHESLTEYIRQVITRVLEKPEIADDQDFYAAGLDSLMTIHASRILQKGIQL RRPDVEAGAINAQTIYGNPTVDRLSQSVMDILDGRAQADIPRAEKIKSLLEKYTSDLPVREVYRENGLPSPSTVI LTGSTGSLGTYLLHDLLNSDSITKIYCLNRSDAEARQKKGFEEKGLHFDENDWKDKVEFLQVSFGEPQFGLDESK YQELLDSVDTIIHNAWKVDFNHSVDSFEGTHIRGVRRFIDFSLNSRNNAHVHFVSSISTVGAWTPDKGDLVPEVP IDDISVVLSQGYGESKHIAERICLEASQRSQVPTSVHRVGQIAGPTSARGQWNRQEWLPTIIATSKAMGKIPDQL GSVAVDWVPVDTLSNIIVEIVNTRHRDSSEARSAVFHLTNPEQTSWSTLIPAVQSEYAVEPVAFSRWLGELESIT NPSSEEVASKPALKLLGFYRGLEGEGSALSVPLDVQRTKAASASMRALGAVSPSLMRNWLQQWQF*
Coding	>Pro_DTO377G3_2|g2871.t1 ATGGAATCTTTTCGGAAAAGACTGCTTGCGACAACGATCGATGAGCAGGCTGAAACCAAACCCACTCAACGATTT GCAGTTATTTCACAGGGATTGGACCTCAGCAATGGGCTCCGAGACATTTCAATCAAAGACCTGGCACAGGCCGTG AACTTCATGTGTTGGTGGATTGAGAGCATCATTGGACCGGCACACTCTGACTCCCCAGAGACGGTGGCCTATATG GGGGGCAACGATGTGCGCTATCTCATCTTCTTTCTTGCATGCCAGAAGACTGGATATCAGGCCTTCTTGCCTTCT ACCAGGAACTCAGACGAAGCGTATGTTCATCTACTGAGCGCGATAAACTGCACAAAGTTCTTCTTCGGCGAGGAG CGTCAAGAACGAGTACTGGAGATACATGGACTTGTACCGAAATTGGACATCTTCCAGGCCCCGACCCTGAACACA ATCCTCAGCGACGAGAGTGGTCTACGCCACTACCCATATACCAAGTCCTATGCCGATGCAGAGGATGACATTGTT TGCATCATCCATAGCTCTGGAACGACAGGCATGCCCAAGCCGGTGTATCTCACCAACGGCTTCATCATGACCTTT GATTCTGTCACTTACCTTGAAAAGCCACCAGGTCGCCGGCCAAATACATTCCACGACCTGGATCAAAGTCAGCTG CTGCTGGCCGCGGCACCTTTCTTCCATCTGATGGGACTAGTAACATTCATCTTCTCGGTGTGGAACGAATGTCCC ATGTTCGTTGCCCCCGATAAGCCACTCTCTGTCGACTATATGATAGAGCTGCTGAGCACTGGCCACCCCACAGTC GCACTCCTGCCACCCTCGGTCCTGGAAGATATGAGCCAATCCGAGAAAGCACTAGCTAGTTTGAAAGAAGTCAAA AAAGTGTATTTCGCCGGCGCGCCTCTGCCCCTAGAGATCGGCGAGAAATTGCGCAAGTATACGGAGATCATAACG GTAATTGGAAGCAGTGAGGCCGGCGTGATCCCAGGGCTAATACCGGAGGACAAAACCAACTGGGGCTACTTCGAA TGGAATGAAGACTACGGAGTGGAAATGCAAGACACCGGCGGCGGCGTGTTCGAGTTGGTGATTCCTCGGAAGAAG GATTCTCGCGACTGGAAGGCCGTTTTCCACACATATCCCGAGCTCGATGCGTATCCAACCAACGATCTCTTCACC CAACACCCAACGGACCCACGTCTGTGGAAGTTCTGCGGGCGCAAGGACGATGTGATTGTCCTCAGCAATGGCGAA AAGTTTAATCCTATCGGGATGGAGGGTATCATCGAGGGACACCCGCTGGTTCGGAAGGCGGTGGTAGTCGGCCAG TCCCGGTTCCAGGCCGGACTGCTCGTCGATCCGAGTCCTGCGGGATGGGATATGGACCCGAAGGTCTTTATTGAG GAGATCTGGCCGGTAGTACAGGCGGCTAACCAGACCATCGCGGCTCATGGCCGGGTAATGAAGAACAAGATCAGG CTCGCTGTGAAGACAAAGCCATTCCAGACGACTCCTAAGGGTAACGTGCGGCGCCGGATGGTGCTTCAGGACTAC GAGGAAGAGATTGATATGATATATACCGAGGACCTCGTGGATGACTTGGACCAGTCTCTACCGCAGACGTTAGAC CATGAGAGTCTTACGGAGTATATCCGCCAGGTTATTACCCGTGTCCTGGAGAAACCCGAGATCGCAGATGATCAG GACTTTTACGCTGCCGGTCTTGATTCTCTAATGACCATTCATGCCTCTCGGATACTGCAAAAGGGCATTCAGCTA CGTCGGCCGGATGTAGAAGCAGGAGCCATCAACGCCCAGACGATCTATGGCAACCCCACAGTCGACCGATTGTCT CAATCCGTGATGGACATCTTAGATGGAAGAGCCCAAGCTGATATCCCGCGAGCAGAGAAGATCAAGAGTCTGCTG GAGAAGTATACGTCTGATCTTCCAGTGCGGGAAGTCTACCGCGAGAATGGATTGCCCTCGCCTTCGACTGTGATT CTGACCGGTTCAACTGGCTCACTGGGTACTTATCTCCTGCATGATCTACTAAACAGCGATTCCATCACCAAGATC TACTGCCTCAATCGTTCGGATGCCGAAGCACGACAGAAGAAAGGCTTCGAAGAAAAAGGCTTACACTTCGACGAA AACGACTGGAAAGACAAGGTCGAGTTCCTACAAGTCTCATTCGGAGAACCACAATTCGGCCTGGACGAGTCCAAG TACCAGGAACTTCTCGACTCGGTCGACACCATCATCCACAACGCCTGGAAAGTCGACTTCAACCACTCCGTCGAT TCGTTCGAGGGCACTCACATCCGGGGTGTGCGGCGCTTTATCGACTTCAGCTTGAACAGCCGCAACAACGCCCAT GTTCACTTCGTCTCCTCCATCAGCACGGTAGGCGCTTGGACCCCCGACAAGGGAGATCTGGTCCCAGAAGTACCG ATCGACGACATTTCAGTCGTTCTCTCACAGGGCTACGGCGAGTCCAAGCACATTGCCGAGCGCATCTGTCTCGAG GCATCGCAAAGATCTCAAGTCCCCACGTCGGTACATCGCGTCGGACAGATCGCGGGACCGACTAGCGCGCGCGGA CAGTGGAATCGACAGGAATGGCTGCCGACGATCATTGCGACGTCAAAAGCGATGGGTAAAATCCCCGACCAACTC GGCTCGGTCGCGGTCGATTGGGTCCCAGTGGACACACTATCCAATATTATAGTGGAAATTGTCAACACACGTCAT CGGGACTCCTCCGAAGCAAGATCTGCCGTGTTTCATCTCACCAATCCCGAGCAGACATCATGGTCGACGTTGATC CCGGCGGTCCAGAGCGAGTATGCAGTCGAGCCAGTTGCGTTCTCGAGGTGGCTTGGCGAGCTGGAGAGTATCACC AATCCCAGCAGTGAGGAAGTTGCCTCCAAGCCGGCACTCAAGCTGCTGGGTTTCTACCGGGGGTTGGAAGGCGAG GGCAGTGCCTTGTCTGTACCGCTGGATGTCCAGCGGACGAAAGCGGCAAGTGCCAGCATGAGAGCGCTGGGCGCG GTCTCTCCCTCGTTGATGCGAAACTGGCTGCAGCAATGGCAATTCTGA
Transcript	>Pro_DTO377G3_2|g2871.t1 ATGGAATCTTTTCGGAAAAGACTGCTTGCGACAACGATCGATGAGCAGGCTGAAACCAAACCCACTCAACGATTT GCAGTTATTTCACAGGGATTGGACCTCAGCAATGGGCTCCGAGACATTTCAATCAAAGACCTGGCACAGGCCGTG AACTTCATGTGTTGGTGGATTGAGAGCATCATTGGACCGGCACACTCTGACTCCCCAGAGACGGTGGCCTATATG GGGGGCAACGATGTGCGCTATCTCATCTTCTTTCTTGCATGCCAGAAGACTGGATATCAGGCCTTCTTGCCTTCT ACCAGGAACTCAGACGAAGCGTATGTTCATCTACTGAGCGCGATAAACTGCACAAAGTTCTTCTTCGGCGAGGAG CGTCAAGAACGAGTACTGGAGATACATGGACTTGTACCGAAATTGGACATCTTCCAGGCCCCGACCCTGAACACA ATCCTCAGCGACGAGAGTGGTCTACGCCACTACCCATATACCAAGTCCTATGCCGATGCAGAGGATGACATTGTT TGCATCATCCATAGCTCTGGAACGACAGGCATGCCCAAGCCGGTGTATCTCACCAACGGCTTCATCATGACCTTT GATTCTGTCACTTACCTTGAAAAGCCACCAGGTCGCCGGCCAAATACATTCCACGACCTGGATCAAAGTCAGCTG CTGCTGGCCGCGGCACCTTTCTTCCATCTGATGGGACTAGTAACATTCATCTTCTCGGTGTGGAACGAATGTCCC ATGTTCGTTGCCCCCGATAAGCCACTCTCTGTCGACTATATGATAGAGCTGCTGAGCACTGGCCACCCCACAGTC GCACTCCTGCCACCCTCGGTCCTGGAAGATATGAGCCAATCCGAGAAAGCACTAGCTAGTTTGAAAGAAGTCAAA AAAGTGTATTTCGCCGGCGCGCCTCTGCCCCTAGAGATCGGCGAGAAATTGCGCAAGTATACGGAGATCATAACG GTAATTGGAAGCAGTGAGGCCGGCGTGATCCCAGGGCTAATACCGGAGGACAAAACCAACTGGGGCTACTTCGAA TGGAATGAAGACTACGGAGTGGAAATGCAAGACACCGGCGGCGGCGTGTTCGAGTTGGTGATTCCTCGGAAGAAG GATTCTCGCGACTGGAAGGCCGTTTTCCACACATATCCCGAGCTCGATGCGTATCCAACCAACGATCTCTTCACC CAACACCCAACGGACCCACGTCTGTGGAAGTTCTGCGGGCGCAAGGACGATGTGATTGTCCTCAGCAATGGCGAA AAGTTTAATCCTATCGGGATGGAGGGTATCATCGAGGGACACCCGCTGGTTCGGAAGGCGGTGGTAGTCGGCCAG TCCCGGTTCCAGGCCGGACTGCTCGTCGATCCGAGTCCTGCGGGATGGGATATGGACCCGAAGGTCTTTATTGAG GAGATCTGGCCGGTAGTACAGGCGGCTAACCAGACCATCGCGGCTCATGGCCGGGTAATGAAGAACAAGATCAGG CTCGCTGTGAAGACAAAGCCATTCCAGACGACTCCTAAGGGTAACGTGCGGCGCCGGATGGTGCTTCAGGACTAC GAGGAAGAGATTGATATGATATATACCGAGGACCTCGTGGATGACTTGGACCAGTCTCTACCGCAGACGTTAGAC CATGAGAGTCTTACGGAGTATATCCGCCAGGTTATTACCCGTGTCCTGGAGAAACCCGAGATCGCAGATGATCAG GACTTTTACGCTGCCGGTCTTGATTCTCTAATGACCATTCATGCCTCTCGGATACTGCAAAAGGGCATTCAGCTA CGTCGGCCGGATGTAGAAGCAGGAGCCATCAACGCCCAGACGATCTATGGCAACCCCACAGTCGACCGATTGTCT CAATCCGTGATGGACATCTTAGATGGAAGAGCCCAAGCTGATATCCCGCGAGCAGAGAAGATCAAGAGTCTGCTG GAGAAGTATACGTCTGATCTTCCAGTGCGGGAAGTCTACCGCGAGAATGGATTGCCCTCGCCTTCGACTGTGATT CTGACCGGTTCAACTGGCTCACTGGGTACTTATCTCCTGCATGATCTACTAAACAGCGATTCCATCACCAAGATC TACTGCCTCAATCGTTCGGATGCCGAAGCACGACAGAAGAAAGGCTTCGAAGAAAAAGGCTTACACTTCGACGAA AACGACTGGAAAGACAAGGTCGAGTTCCTACAAGTCTCATTCGGAGAACCACAATTCGGCCTGGACGAGTCCAAG TACCAGGAACTTCTCGACTCGGTCGACACCATCATCCACAACGCCTGGAAAGTCGACTTCAACCACTCCGTCGAT TCGTTCGAGGGCACTCACATCCGGGGTGTGCGGCGCTTTATCGACTTCAGCTTGAACAGCCGCAACAACGCCCAT GTTCACTTCGTCTCCTCCATCAGCACGGTAGGCGCTTGGACCCCCGACAAGGGAGATCTGGTCCCAGAAGTACCG ATCGACGACATTTCAGTCGTTCTCTCACAGGGCTACGGCGAGTCCAAGCACATTGCCGAGCGCATCTGTCTCGAG GCATCGCAAAGATCTCAAGTCCCCACGTCGGTACATCGCGTCGGACAGATCGCGGGACCGACTAGCGCGCGCGGA CAGTGGAATCGACAGGAATGGCTGCCGACGATCATTGCGACGTCAAAAGCGATGGGTAAAATCCCCGACCAACTC GGCTCGGTCGCGGTCGATTGGGTCCCAGTGGACACACTATCCAATATTATAGTGGAAATTGTCAACACACGTCAT CGGGACTCCTCCGAAGCAAGATCTGCCGTGTTTCATCTCACCAATCCCGAGCAGACATCATGGTCGACGTTGATC CCGGCGGTCCAGAGCGAGTATGCAGTCGAGCCAGTTGCGTTCTCGAGGTGGCTTGGCGAGCTGGAGAGTATCACC AATCCCAGCAGTGAGGAAGTTGCCTCCAAGCCGGCACTCAAGCTGCTGGGTTTCTACCGGGGGTTGGAAGGCGAG GGCAGTGCCTTGTCTGTACCGCTGGATGTCCAGCGGACGAAAGCGGCAAGTGCCAGCATGAGAGCGCTGGGCGCG GTCTCTCCCTCGTTGATGCGAAACTGGCTGCAGCAATGGCAATTCTGA
Gene	>Pro_DTO377G3_2|g2871.t1 ATGGAATCTTTTCGGAAAAGACTGCTTGCGACAACGATCGATGAGCAGGCTGAAACCAAACCCACTCAACGATTT GCAGTTATTTCACAGGGATTGGACCTCAGCAATGGGCTCCGAGACATTTCAATCAAAGACCTGGCACAGGCCGTG AACTTCATGTGTTGGTGGATTGAGAGCATCATTGGACCGGCACACTCTGACTCCCCAGAGACGGTGGCCTATATG GGGGGCAACGATGTGCGCTATCTCATCTTCTTTCTTGCATGCCAGAAGACTGGATATCAGGTAAGGAAACATGCC ACTCAAACTGAGAATATAACAGCCGGACTGACTCTTATAGGCCTTCTTGCCTTCTACCAGGAACTCAGACGAAGC GTATGTTCATCTACTGAGCGCGATAAACTGCACAAAGTTCTTCTTCGGCGAGGAGCGTCAAGAACGAGTACTGGA GATACATGGACTTGTACCGAAATTGGACATCTTCCAGGCCCCGACCCTGAACACAATCCTCAGCGACGAGAGTGG TCTACGCCACTACCCATATACCAAGTCCTATGCCGATGCAGAGGATGACATTGTTTGCATCATCCATAGCTCTGG AACGACAGGTAAATCCCATGAACGTGGCACTGTGACTGTGAACCAAGCTAATTCCCGACAGGCATGCCCAAGCCG GTGTATCTCACCAACGGCTTCATCATGACCTTTGATTCTGTCACTTACCTTGAAAAGCCACCAGGTCGCCGGCCA AATACATTCCACGACCTGGATCAAAGTCAGCTGCTGCTGGCCGCGGCACCTTTCTTCCATCTGATGGGACTAGTA ACATTCATCTTCTCGGTGTGGAACGAATGTCCCATGTTCGTTGCCCCCGATAAGCCACTCTCTGTCGACTATATG ATAGAGCTGCTGAGCACTGGCCACCCCACAGTCGCACTCCTGCCACCCTCGGTCCTGGAAGATATGAGCCAATCC GAGAAAGCACTAGCTAGTTTGAAAGAAGTCAAAAAAGTGTATTTCGCCGGCGCGCCTCTGCCCCTAGAGATCGGC GAGAAATTGCGCAAGTATACGGAGATCATAACGGTAATTGGAAGCAGTGAGGCCGGCGTGATCCCAGGGCTAATA CCGGAGGACAAAACCAACTGGGGCTACTTCGAATGGAATGAAGACTACGGAGTGGAAATGCAAGACACCGGCGGC GGCGTGTTCGAGTTGGTGATTCCTCGGAAGAAGGATTCTCGCGACTGGAAGGCCGTTTTCCACACATATCCCGAG CTCGATGCGTATCCAACCAACGATCTCTTCACCCAACACCCAACGGACCCACGTCTGTGGAAGTTCTGCGGGCGC AAGGACGATGTGATTGTCCTCAGCAATGGCGAAAAGTTTAATCCTATCGGGATGGAGGGTATCATCGAGGGACAC CCGCTGGTTCGGAAGGCGGTGGTAGTCGGCCAGTCCCGGTTCCAGGCCGGACTGCTCGTCGATCCGAGTCCTGCG GGATGGGATATGGACCCGAAGGTCTTTATTGAGGAGATCTGGCCGGTAGTACAGGCGGCTAACCAGACCATCGCG GCTCATGGCCGGGTAATGAAGAACAAGATCAGGCTCGCTGTGAAGACAAAGCCATTCCAGACGACTCCTAAGGGT AACGTGCGGCGCCGGATGGTGCTTCAGGACTACGAGGAAGAGATTGATATGATATATACCGAGGACCTCGTGGAT GACTTGGACCAGTCTCTACCGCAGACGTTAGACCATGAGAGTCTTACGGAGTATATCCGCCAGGTTATTACCCGT GTCCTGGAGAAACCCGAGATCGCAGATGATCAGGACTTTTACGCTGCCGGTCTTGATTCTCTAATGACCATTCAT GCCTCTCGGATACTGCAAAAGGGCATTCAGCTACGTCGGCCGGATGTAGAAGCAGGAGCCATCAACGCCCAGACG ATCTATGGCAACCCCACAGTCGACCGATTGTCTCAATCCGTGATGGACATCTTAGATGGAAGAGCCCAAGCTGAT ATCCCGCGAGCAGAGAAGATCAAGAGTCTGCTGGAGAAGTATACGTCTGATCTTCCAGTGCGGGAAGTCTACCGC GAGAATGGATTGCCCTCGCCTTCGACTGTGATTCTGACCGGTTCAACTGGCTCACTGGGTACTTATCTCCTGCAT GATCTACTAAACAGCGATTCCATCACCAAGATCTACTGCCTCAATCGTTCGGATGCCGAAGCACGACAGAAGAAA GGCTTCGAAGAAAAAGGCTTACACTTCGACGAAAACGACTGGAAAGACAAGGTCGAGTTCCTACAAGTCTCATTC GGAGAACCACAATTCGGCCTGGACGAGTCCAAGTACCAGGAACTTCTCGACTCGGTCGACACCATCATCCACAAC GCCTGGAAAGTCGACTTCAACCACTCCGTCGATTCGTTCGAGGGCACTCACATCCGGGGTGTGCGGCGCTTTATC GACTTCAGCTTGAACAGCCGCAACAACGCCCATGTTCACTTCGTCTCCTCCATCAGCACGGTAGGCGCTTGGACC CCCGACAAGGGAGATCTGGTCCCAGAAGTACCGATCGACGACATTTCAGTCGTTCTCTCACAGGGCTACGGCGAG TCCAAGCACATTGCCGAGCGCATCTGTCTCGAGGCATCGCAAAGATCTCAAGTCCCCACGTCGGTACATCGCGTC GGACAGATCGCGGGACCGACTAGCGCGCGCGGACAGTGGAATCGACAGGAATGGCTGCCGACGATCATTGCGACG TCAAAAGCGATGGGTAAAATCCCCGACCAACTCGGCTCGGTCGCGGTCGATTGGGTCCCAGTGGTAAGTCCCCCG AAAATTATGATTCACTAGCTCAGCCAAGAGAAAAAAATTTTAATTTTCTAACTTGATTTTAGGACACACTATCCA ATATTATAGTGGAAATTGTCAACACACGTCATCGGGACTCCTCCGAAGCAAGATCTGCCGTGTTTCATCTCACCA ATCCCGAGCAGACATCATGGTCGACGTTGATCCCGGCGGTCCAGAGCGAGTATGCAGTCGAGCCAGTTGCGTTCT CGAGGTGGCTTGGCGAGCTGGAGAGTATCACCAATCCCAGCAGTGAGGAAGTTGCCTCCAAGCCGGCACTCAAGC TGCTGGGTTTCTACCGGGGGTTGGAAGGCGAGGGCAGTGCCTTGTCTGTACCGCTGGATGTCCAGCGGACGAAAG CGGCAAGTGCCAGCATGAGAGCGCTGGGCGCGGTCTCTCCCTCGTTGATGCGAAACTGGCTGCAGCAATGGCAAT TCTGA