Fungal Genomics

Agaricus bisporus var bisporus H39 Agaricus bisporus var bisporus H97 Agaricus bisporus var burnettii H119p4 Aspergillus niger CBS 112.32 Aspergillus niger CBS 113.50 Aspergillus niger CBS 115988 Aspergillus niger CBS 115989 Aspergillus niger CBS 118.52 Aspergillus niger CBS 124.48 Aspergillus niger CBS 131.52 Aspergillus niger CBS 133816 Aspergillus niger CBS 147320 Aspergillus niger CBS 147321 Aspergillus niger CBS 147322 Aspergillus niger CBS 147323 Aspergillus niger CBS 147324 Aspergillus niger CBS 147343 Aspergillus niger CBS 147344 Aspergillus niger CBS 147345 Aspergillus niger CBS 147346 Aspergillus niger CBS 147347 Aspergillus niger CBS 147352 Aspergillus niger CBS 147353 Aspergillus niger CBS 147371 Aspergillus niger CBS 147482 Aspergillus niger CBS 630.78 Aspergillus niger CBS 769.97 Niveomyces coronatus CBS 149186 Ophiocordyceps australis 1348a (Ghana) Ophiocordyceps australis map64 (Brazil) Ophiocordyceps camponoti-floridani Ophiocordyceps camponoti-rufipedis Ophiocordyceps kimflemingae Ophiocordyceps subramaniannii Penicillium roqueforti DTO002I6 Penicillium roqueforti DTO003C3 Penicillium roqueforti DTO003H1 (CBS 147308) Penicillium roqueforti DTO006G1 Penicillium roqueforti DTO006G7 Penicillium roqueforti DTO012A1 Penicillium roqueforti DTO012A2 (CBS 147309) Penicillium roqueforti DTO012A6 (CBS 147310) Penicillium roqueforti DTO012A7 Penicillium roqueforti DTO012A8 Penicillium roqueforti DTO012A9 Penicillium roqueforti DTO013E5 Penicillium roqueforti DTO013F2 Penicillium roqueforti DTO013F5 (CBS 147311) Penicillium roqueforti DTO027I6 Penicillium roqueforti DTO032C6 Penicillium roqueforti DTO039G3 Penicillium roqueforti DTO046C5 Penicillium roqueforti DTO070G2 (CBS 147317) Penicillium roqueforti DTO081F9 (CBS 147318) Penicillium roqueforti DTO101D6 (CBS 147325) Penicillium roqueforti DTO102I9 (CBS 147326) Penicillium roqueforti DTO126G2 (CBS 147330) Penicillium roqueforti DTO127F7 (CBS 147331) Penicillium roqueforti DTO127F9 (CBS 147332) Penicillium roqueforti DTO130C1 (CBS 147333) Penicillium roqueforti DTO163C3 (CBS 147337) Penicillium roqueforti DTO163F5 (CBS 147338) Penicillium roqueforti DTO163G4 (CBS 147339) Penicillium roqueforti DTO265D5 (CBS 147372) Penicillium roqueforti DTO369A1 (CBS 147354) Penicillium roqueforti DTO375B1 (CBS 147355) Penicillium roqueforti DTO377G2 (LCP 96.3914a) Penicillium roqueforti LCP96 04111 Rhodonia placenta FPRL280 Torrubiellomyces zombiae CBS 149187

General Properties

Protein ID	Pro_DTO377G3_2|g2588.t1
Gene name
Location	scaffold_03:420411..424809
Strand	+
Gene length (bp)	4398
Transcript length (bp)	3033
Coding sequence length (bp)	3033
Protein length (aa)	1011

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PFAM Domains

PFAM Domain ID	Short name	Long name	E-value	Start	End
PF11951	Fungal_trans_2	Fungal specific transcription factor domain	3.6E-52	617	1002
PF13520	AA_permease_2	Amino acid permease	1.7E-40	45	380
PF00324	AA_permease	Amino acid permease	1.6E-21	59	380
PF00172	Zn_clus	Fungal Zn(2)-Cys(6) binuclear cluster domain	1.3E-07	409	442

GO

GO Term	Description	Terminal node
GO:0016020	membrane	Yes
GO:0008270	zinc ion binding	Yes
GO:0055085	transmembrane transport	Yes
GO:0022857	transmembrane transporter activity	Yes
GO:0006355	regulation of transcription, DNA-templated	Yes
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Yes
GO:0008150	biological_process	No
GO:0140110	transcription regulator activity	No
GO:0010468	regulation of gene expression	No
GO:0051234	establishment of localization	No
GO:0010556	regulation of macromolecule biosynthetic process	No
GO:0050794	regulation of cellular process	No
GO:0005575	cellular_component	No
GO:0060255	regulation of macromolecule metabolic process	No
GO:0005488	binding	No
GO:0051252	regulation of RNA metabolic process	No
GO:0006810	transport	No
GO:0043167	ion binding	No
GO:0009987	cellular process	No
GO:0046872	metal ion binding	No
GO:0031323	regulation of cellular metabolic process	No
GO:1903506	regulation of nucleic acid-templated transcription	No
GO:0050789	regulation of biological process	No
GO:2001141	regulation of RNA biosynthetic process	No
GO:0046914	transition metal ion binding	No
GO:0065007	biological regulation	No
GO:0003674	molecular_function	No
GO:0051171	regulation of nitrogen compound metabolic process	No
GO:0019222	regulation of metabolic process	No
GO:0019219	regulation of nucleobase-containing compound metabolic process	No
GO:0031326	regulation of cellular biosynthetic process	No
GO:0051179	localization	No
GO:0080090	regulation of primary metabolic process	No
GO:0009889	regulation of biosynthetic process	No
GO:0005215	transporter activity	No
GO:0043169	cation binding	No
GO:0110165	cellular anatomical entity	No
GO:0003700	DNA-binding transcription factor activity	No

SignalP

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SignalP signal predicted	Location (based on Ymax)	D score (significance: > 0.45)
No	1 - 55	0.5

Transmembrane Domains

Domain #	Start	End	Length
1	40	62	22
2	82	104	22
3	125	147	22
4	162	181	19
5	188	210	22
6	276	298	22
7	328	350	22

Transcription Factor Class

Transcription Factor Class (based on PFAM domains)
Fungal Specific TF

Expression data

Analysis 1: Genome-wide gene expression in conidia of Penicillium roqueforti during growth at various temperatures and for various amounts of time. Published in Punt et al., 2020.

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Sequences

Type of sequence	Sequence
Locus	Download genbank file of locus The gene with 5 kb flanks (if sufficient flanking sequence is available). For use in cloning design programs. NOTE: features (genes or exons) that are only partially contained within the sequence are completely excluded.
Protein	>Pro_DTO377G3_2|g2588.t1 MAQFETKENPGDLESSLQGSTKEVTETQVTPVLAKSFNLLSACATGITTGNAWAVLGGGIIASLYNGGPPGVIYE FATASFFYCFIAASIAELASAIPASGGVYHWATITAGPRYGRLCGWFAGWLNGLAWTFAVAGNCSMTGSMIVYSY TLYHPEVKPQRWHVFVCYLIITWLCCLTVMFCQRALAVISRIGSFFIIVGFVISVLVCAIMPSRDGAGYASNEFV WTDWNNITGYSDGFTFLAGMLNGAFAIGAIDCVTHIAEEIPDARRNIPKALACQVTIGFATGLCYLISIFYAVTD LSLIVNADSISPLGDIYLQATGSRAGAVGLLTLTIVPIFIATIGCYITAGRTFYVLGRDNATPFSKHIGAISPKW HSPLQTDTMGGPVTAPRKQTKRIRQAKQKSVTFTGCWTCRSRKVKCDERQENGCRVCQKSRLECAGYGVNLCWIT DKKRDIQGLRRRQVRLEQSTSPSISDAEINRMISSLDTISTPSRTVSIGPFSIFSSREPGIEYLEPHASLENSHQ TQDCTSEIAPSPVDTVDLSSGDFEIITNDTVIPNSEIHFIDFPSDWESVIAMMDTSNSPTLPYSRKMSLTIYPSP DMELSIPLFKDHNTSMLMYHYKNHVAELLQPVFHPRNPWRTTYLPFALEGCPEFCLVQNPVPSSEVSISLFHSIL SSAAFHLRNIMGGSREYHKLGLQHRAKALQALKTALITPNDSEKYTVYLTAMLALVTIDTMTGEDSDFPIHLKGC RQLERPGRASDSPNDSSRQVSSICHFLSLLARTTAHELEHRQWTTEGPLFEQPYFHDDDTNIQYMYGITPYLGNL LQRTCQVAEYLAFYQGAEVPTILLEACSALKDEIFSWDIDSESFHHVMLEQPTMLEIIRCQALSFHSAIAIFYYR AIEDSSPVDLQQQVGAIWKNLSLAEDLKDVYSSDGKRAAPMSWPAFIAACEAIDRQPWVEWWERVQRYSMGNFKR QWKVIQEIWNIMDLDENVLNWRDALKQSGKLVLPI*
Coding	>Pro_DTO377G3_2|g2588.t1 ATGGCACAGTTTGAAACCAAAGAAAACCCTGGCGATCTCGAGTCTTCCCTCCAAGGATCGACAAAAGAGGTTACT GAGACTCAGGTCACGCCTGTACTTGCGAAGAGCTTTAATCTCCTGAGTGCTTGCGCAACTGGAATCACTACCGGG AATGCTTGGGCGGTCCTGGGAGGCGGAATTATTGCCTCACTCTACAATGGTGGACCACCTGGAGTAATATACGAG TTCGCCACTGCCTCCTTTTTCTATTGCTTCATTGCCGCATCAATTGCCGAGCTCGCTTCTGCTATTCCGGCATCT GGGGGCGTTTATCACTGGGCTACAATAACCGCTGGTCCTCGTTATGGCAGGTTGTGCGGCTGGTTTGCAGGGTGG TTGAATGGCCTCGCATGGACATTCGCCGTAGCAGGGAACTGTTCCATGACAGGAAGCATGATTGTCTATTCATAC ACGCTCTACCATCCAGAGGTAAAACCGCAGCGCTGGCATGTTTTTGTTTGCTATTTGATCATCACCTGGCTATGT TGTCTTACTGTGATGTTCTGCCAACGGGCTCTCGCGGTCATCAGCAGGATCGGATCGTTCTTCATTATTGTCGGT TTTGTCATCTCAGTCTTAGTTTGTGCTATTATGCCAAGCAGGGATGGAGCAGGATATGCATCGAATGAATTCGTC TGGACAGACTGGAACAACATTACTGGTTACTCTGACGGATTCACATTCCTTGCAGGCATGTTGAACGGGGCATTT GCAATCGGCGCCATTGACTGCGTCACTCACATTGCAGAAGAGATTCCTGATGCGAGACGGAATATCCCCAAAGCA CTTGCTTGCCAAGTGACCATCGGCTTCGCAACTGGTCTTTGCTATCTGATTTCCATATTCTATGCTGTCACCGAC CTATCCCTCATTGTGAACGCCGATTCTATCTCTCCTCTCGGTGATATCTATTTGCAAGCAACCGGTTCCCGAGCA GGTGCAGTGGGGCTTCTTACACTCACGATCGTACCCATCTTCATTGCAACGATTGGATGCTATATTACCGCAGGA AGGACATTCTATGTCCTGGGTCGCGATAACGCGACGCCATTTTCCAAACATATCGGGGCTATAAGCCCGAAATGG CATAGCCCACTTCAGACCGATACAATGGGTGGCCCCGTGACAGCTCCTAGAAAACAAACCAAACGTATTCGCCAA GCAAAGCAGAAATCGGTGACATTCACAGGATGCTGGACCTGCAGGTCTCGGAAGGTCAAATGTGATGAGCGTCAA GAAAATGGGTGTCGAGTTTGCCAGAAATCCCGCCTGGAATGCGCCGGCTACGGTGTGAATCTGTGCTGGATTACA GATAAGAAGCGAGATATTCAAGGCCTACGACGCAGGCAGGTCAGACTAGAACAATCCACTTCCCCTAGCATTTCG GATGCCGAGATCAACCGAATGATATCCTCTCTTGACACAATCTCAACACCATCGCGCACAGTCAGTATAGGGCCC TTTTCAATATTCTCCAGCCGGGAACCCGGCATTGAATATCTCGAACCTCACGCTTCTTTGGAGAACAGTCATCAG ACTCAGGACTGTACTTCTGAGATCGCTCCTAGTCCAGTGGACACAGTTGACTTGTCCAGCGGAGATTTTGAAATA ATTACGAATGACACTGTCATTCCTAATTCAGAAATCCATTTCATAGATTTCCCCTCAGACTGGGAGTCAGTGATA GCCATGATGGATACATCGAATTCTCCAACATTACCATACTCGAGAAAAATGTCACTCACAATATATCCATCACCA GACATGGAGCTTTCAATACCTCTGTTCAAAGATCACAATACGTCAATGCTTATGTATCACTACAAAAATCATGTC GCGGAGCTCCTACAACCAGTTTTCCATCCGAGGAACCCTTGGCGCACAACATATCTCCCATTCGCCCTCGAGGGC TGCCCTGAGTTCTGTCTCGTCCAAAATCCGGTGCCTTCCTCGGAAGTCTCGATTTCACTATTCCACAGTATATTA TCATCGGCTGCATTCCACCTCCGGAACATCATGGGTGGTTCACGAGAATACCACAAACTTGGTCTCCAGCATCGG GCCAAAGCTTTACAAGCACTCAAGACTGCCCTCATAACGCCCAATGACTCTGAGAAATATACAGTCTATCTCACG GCAATGCTGGCCTTGGTCACAATCGATACAATGACGGGAGAAGATTCAGATTTTCCAATTCATCTCAAGGGTTGT CGTCAGCTGGAAAGACCAGGCCGTGCGTCCGATTCACCCAATGACTCCAGTCGGCAGGTTAGCAGTATTTGCCAT TTCCTAAGCCTCCTGGCTCGAACGACAGCACACGAGCTAGAGCATAGACAATGGACAACAGAAGGTCCATTATTT GAGCAGCCTTACTTCCACGACGACGACACCAACATCCAATACATGTATGGGATTACCCCATATCTGGGGAATCTT CTACAAAGGACCTGTCAGGTGGCCGAGTATTTAGCCTTCTACCAGGGTGCTGAAGTGCCAACAATCTTGCTGGAG GCATGCTCGGCATTAAAAGATGAAATCTTTTCGTGGGATATAGACTCCGAGTCTTTCCATCACGTCATGCTAGAG CAGCCGACGATGCTTGAGATAATACGTTGCCAGGCTCTATCATTTCACAGCGCGATCGCAATTTTTTATTATCGA GCAATTGAAGACTCCAGCCCGGTGGATCTTCAGCAGCAAGTAGGGGCAATTTGGAAGAACCTTTCGCTGGCAGAA GACCTTAAAGATGTATACTCAAGTGACGGAAAACGCGCAGCTCCTATGTCTTGGCCAGCATTTATCGCTGCATGC GAGGCGATCGATCGACAACCTTGGGTTGAATGGTGGGAGCGAGTTCAGAGGTACTCAATGGGCAATTTCAAAAGG CAATGGAAAGTCATACAGGAAATCTGGAACATCATGGATTTAGATGAGAATGTGCTTAACTGGAGAGATGCGCTC AAACAATCGGGCAAGTTGGTCTTGCCTATCTGA
Transcript	>Pro_DTO377G3_2|g2588.t1 ATGGCACAGTTTGAAACCAAAGAAAACCCTGGCGATCTCGAGTCTTCCCTCCAAGGATCGACAAAAGAGGTTACT GAGACTCAGGTCACGCCTGTACTTGCGAAGAGCTTTAATCTCCTGAGTGCTTGCGCAACTGGAATCACTACCGGG AATGCTTGGGCGGTCCTGGGAGGCGGAATTATTGCCTCACTCTACAATGGTGGACCACCTGGAGTAATATACGAG TTCGCCACTGCCTCCTTTTTCTATTGCTTCATTGCCGCATCAATTGCCGAGCTCGCTTCTGCTATTCCGGCATCT GGGGGCGTTTATCACTGGGCTACAATAACCGCTGGTCCTCGTTATGGCAGGTTGTGCGGCTGGTTTGCAGGGTGG TTGAATGGCCTCGCATGGACATTCGCCGTAGCAGGGAACTGTTCCATGACAGGAAGCATGATTGTCTATTCATAC ACGCTCTACCATCCAGAGGTAAAACCGCAGCGCTGGCATGTTTTTGTTTGCTATTTGATCATCACCTGGCTATGT TGTCTTACTGTGATGTTCTGCCAACGGGCTCTCGCGGTCATCAGCAGGATCGGATCGTTCTTCATTATTGTCGGT TTTGTCATCTCAGTCTTAGTTTGTGCTATTATGCCAAGCAGGGATGGAGCAGGATATGCATCGAATGAATTCGTC TGGACAGACTGGAACAACATTACTGGTTACTCTGACGGATTCACATTCCTTGCAGGCATGTTGAACGGGGCATTT GCAATCGGCGCCATTGACTGCGTCACTCACATTGCAGAAGAGATTCCTGATGCGAGACGGAATATCCCCAAAGCA CTTGCTTGCCAAGTGACCATCGGCTTCGCAACTGGTCTTTGCTATCTGATTTCCATATTCTATGCTGTCACCGAC CTATCCCTCATTGTGAACGCCGATTCTATCTCTCCTCTCGGTGATATCTATTTGCAAGCAACCGGTTCCCGAGCA GGTGCAGTGGGGCTTCTTACACTCACGATCGTACCCATCTTCATTGCAACGATTGGATGCTATATTACCGCAGGA AGGACATTCTATGTCCTGGGTCGCGATAACGCGACGCCATTTTCCAAACATATCGGGGCTATAAGCCCGAAATGG CATAGCCCACTTCAGACCGATACAATGGGTGGCCCCGTGACAGCTCCTAGAAAACAAACCAAACGTATTCGCCAA GCAAAGCAGAAATCGGTGACATTCACAGGATGCTGGACCTGCAGGTCTCGGAAGGTCAAATGTGATGAGCGTCAA GAAAATGGGTGTCGAGTTTGCCAGAAATCCCGCCTGGAATGCGCCGGCTACGGTGTGAATCTGTGCTGGATTACA GATAAGAAGCGAGATATTCAAGGCCTACGACGCAGGCAGGTCAGACTAGAACAATCCACTTCCCCTAGCATTTCG GATGCCGAGATCAACCGAATGATATCCTCTCTTGACACAATCTCAACACCATCGCGCACAGTCAGTATAGGGCCC TTTTCAATATTCTCCAGCCGGGAACCCGGCATTGAATATCTCGAACCTCACGCTTCTTTGGAGAACAGTCATCAG ACTCAGGACTGTACTTCTGAGATCGCTCCTAGTCCAGTGGACACAGTTGACTTGTCCAGCGGAGATTTTGAAATA ATTACGAATGACACTGTCATTCCTAATTCAGAAATCCATTTCATAGATTTCCCCTCAGACTGGGAGTCAGTGATA GCCATGATGGATACATCGAATTCTCCAACATTACCATACTCGAGAAAAATGTCACTCACAATATATCCATCACCA GACATGGAGCTTTCAATACCTCTGTTCAAAGATCACAATACGTCAATGCTTATGTATCACTACAAAAATCATGTC GCGGAGCTCCTACAACCAGTTTTCCATCCGAGGAACCCTTGGCGCACAACATATCTCCCATTCGCCCTCGAGGGC TGCCCTGAGTTCTGTCTCGTCCAAAATCCGGTGCCTTCCTCGGAAGTCTCGATTTCACTATTCCACAGTATATTA TCATCGGCTGCATTCCACCTCCGGAACATCATGGGTGGTTCACGAGAATACCACAAACTTGGTCTCCAGCATCGG GCCAAAGCTTTACAAGCACTCAAGACTGCCCTCATAACGCCCAATGACTCTGAGAAATATACAGTCTATCTCACG GCAATGCTGGCCTTGGTCACAATCGATACAATGACGGGAGAAGATTCAGATTTTCCAATTCATCTCAAGGGTTGT CGTCAGCTGGAAAGACCAGGCCGTGCGTCCGATTCACCCAATGACTCCAGTCGGCAGGTTAGCAGTATTTGCCAT TTCCTAAGCCTCCTGGCTCGAACGACAGCACACGAGCTAGAGCATAGACAATGGACAACAGAAGGTCCATTATTT GAGCAGCCTTACTTCCACGACGACGACACCAACATCCAATACATGTATGGGATTACCCCATATCTGGGGAATCTT CTACAAAGGACCTGTCAGGTGGCCGAGTATTTAGCCTTCTACCAGGGTGCTGAAGTGCCAACAATCTTGCTGGAG GCATGCTCGGCATTAAAAGATGAAATCTTTTCGTGGGATATAGACTCCGAGTCTTTCCATCACGTCATGCTAGAG CAGCCGACGATGCTTGAGATAATACGTTGCCAGGCTCTATCATTTCACAGCGCGATCGCAATTTTTTATTATCGA GCAATTGAAGACTCCAGCCCGGTGGATCTTCAGCAGCAAGTAGGGGCAATTTGGAAGAACCTTTCGCTGGCAGAA GACCTTAAAGATGTATACTCAAGTGACGGAAAACGCGCAGCTCCTATGTCTTGGCCAGCATTTATCGCTGCATGC GAGGCGATCGATCGACAACCTTGGGTTGAATGGTGGGAGCGAGTTCAGAGGTACTCAATGGGCAATTTCAAAAGG CAATGGAAAGTCATACAGGAAATCTGGAACATCATGGATTTAGATGAGAATGTGCTTAACTGGAGAGATGCGCTC AAACAATCGGGCAAGTTGGTCTTGCCTATCTGA
Gene	>Pro_DTO377G3_2|g2588.t1 ATGGCACAGTTTGAAACCAAAGAAAACCCTGGCGATCTCGAGTCTTCCCTCCAAGGATCGACAAAAGAGGTTACT GAGACTCAGGTCACGCCTGTACTTGCGAAGAGCTTTAATCTCCTGAGTGCTTGCGCAACTGGAATCACTACCGGG AATGCTTGGGCGGTCCTGGGAGGCGGAATTGTAAGCACCAGATACTCTCTCCAAATTGTGCACTACTAAAACATC TTAGATTGCCTCACTCTACAATGGTGGACCACCTGGAGTAATATACGAGTTGTAGGTCCCCACACGTTTACGGAA GTTTTTCCTAGGATGCTTACACGAAGGATAGCGCCACTGCCTCCTTTTTCTATTGCTTCATTGCCGCATCAATTG CCGAGCTCGCTTCTGCTATTCCGGCATCTGGGGGCGTTTATCACTGGGCTACAATAACCGCTGGTCCTCGTTATG GCAGGTTGTGCGGCTGGTTTGCAGGGTGGTTGAATGGCCTCGCATGGACATTCGCCGTAGCAGGGAACTGTTCCA TGACAGGAAGCATGATTGTCTATTCATACACGCTCTACCATCCAGAGGTAAAACCGCAGCGCTGGCATGTTTTTG TTTGCTATTTGATCATCACCTGGCTATGTTGTCTTACTGTGATGTTCTGCCAACGGGCTCTCGCGGTCATCAGCA GGATCGGATCGTTCTTCATTATTGTCGGTTTTGTCATCTCAGTCTTAGTTTGTGCTATTATGCCAAGCAGGGATG GAGCAGGATATGCATCGAATGAATTCGTCTGGACAGACTGGAACAACATTACTGGTTACTCTGACGGATTCACAT TCCTTGCAGGCATGTTGAACGGGGCATTTGCAATCGGCGCCATTGACTGCGTCACTCACATTGCAGAAGAGATTC CTGAGTAGGCAATATCGGTCTATGGTAATGCTTCTTTCGCTGACACTTCGACTAGTGCGAGACGGAATATCCCCA AAGCACTTGCTTGCCAAGTGACCATCGGCTTCGCAACTGGTCTTTGCTATCTGATTTCCATATTCTATGCTGTCA CCGACCTATCCCTCATTGTGAACGCCGATTCTATCTCTCCTCTCGGTGATATCTATTTGCAAGCAACCGGTTCCC GAGCAGGTGCAGTGGGGCTTCTTACACTCACGATCGTACCCATCTTCATTGCAACGATTGGATGCTATATTACCG CAGGAAGGACATTCTATGTCCTGGGTCGCGATAACGCGACGCCATTTTCCAAACATATCGGGGCTATAAGCCCGA AATGGCATAGCCCACTGTATGCAACTTTGGCATGCGGAGTGTTTCTGACATGTATCGGAGCAATTTATGTGGGAT CCTATACTGCCTTCTCGGCCTTTATCGGTTCGTTTGTGCTGCTGACGACAGTCTCATACTTCCTCGCGATATTTC CACATTTGATAACTGGACGCAAGAACATCCGCCCTGGTCCATTTTGGATGGGGAAAATTGGCCCTGTTGTCAATT CTGTCGCATGCATGTACATTGCTGTCTCTTTTGTGATTTACTGCTTCCCTTATACCCTGCCAACATCCCCGGAAG ATATGAACTATACCAGTGTGATCACATGTGGATTGACGTTGTTAGTGGCGCTGTGGTGGATATTGCACGGAAAAG GGAACTATACAGGACCGCAGGTGGAGTTGCACTGAGATAGGCTGAAGCATTCCGTGCCAGTCTGTCAATGGGTTG AGCCAATGATATCAATCGAAGATTATACATAGAAATGTTGTCTACCAAATTAAGCCTTTTCTTGCCTTCTTCCAC CGTAAGAAGGGAGAAGATATCTATAAAAAGAAACATCTAAAGAACTACTATCAACCCAACTAATGGCAGAGGCCG CAAAAGCCATTATCCTGGTGTGGCTAAAAATACGTCCATTCTACATGTCCAACTGGTCTAAGATTACTTGCTCTC GCTGGCTCCTTCCCTTTTCAAAAGGCCTATCCAAGATAGGGTGATAAGATAAGACACTGATAAAGAATTGATAAG ACCTCGGCTTGCCAACCTGATAAGGCGGAGTTCATCCCCAAAATATGTTATGTCATGGAATCAAGATATTTGAAC CCCACAGTCTTGGGGTCCAGAGCAGATATCTTTGCACAAGGGGCACATCATCGGCTATTACCTGCAATTATTGGT CCTCACTGACCCCGTATCTCAAGCTAGCTCCACTATCGAGAACTGCGTGGTCTTGACCATCCAACTGCACGTTGT GCCATAACGCGGGTCTCTCTGATACCCTTACGACCATCGAAAGGTGACTCCCATTGCTCATATTGACAGTCAGAC CGATACAATGGGTGGCCCCGTGACAGCTCCTAGAAAACAAACCAAACGTATTCGCCAAGCAAAGCAGAAATCGGT GACATTCACAGGGTAATACATCAAGTTTCAACTATATTCGAACTTCCACGTACCTTTCAAGCTGACATGAACAGA TGCTGGACCTGCAGGTCTCGGAAGGTCAAATGTGATGAGCGTCAAGAAAATGGGTGTCGAGTTTGCCAGAAATCC CGCCTGGAATGCGCCGGCTACGGTGTGAATCTGTGCTGGATTACAGATAAGAAGCGAGATATTCAAGGCCTACGA CGCAGGCAGGTCAGACTAGGTGAGTTCCGACCCTCTTCTTGGCCTTGTTTCAAAGGCACATTCACTGATAGATAT CATAATTAAGAACAATCCACTTCCCCTAGCATTTCGGATGCCGAGATCAACCGAATGATATCCTCTCTTGACACA ATCTCAACACCATCGCGCACAGTCAGTATAGGGCCCTTTTCAATATTCTCCAGCCGGGAACCCGGCATTGAATAT CTCGAACCTCACGCTTCTTTGGAGAACAGTCATCAGACTCAGGACTGTACTTCTGAGATCGCTCCTAGTCCAGTG GACACAGTTGACTTGTCCAGCGGAGATTTTGAAATAATTACGAATGACACTGTCATTCCTAATTCAGAAATCCAT TTCATAGATTTCCCCTCAGACTGGGAGTCAGTGATAGCCATGATGGATACATCGAATTCTCCAACATTACCATAC TCGAGAAAAATGTCACTCACAATATATCCATCACCAGACATGGAGCTTTCAATACCTCTGTTCAAAGATCACAAT ACGTCAATGCTTATGTATCACTACAAAAATCATGTCGCGGAGCTCCTACAACCAGTTTTCCATCCGAGGAACCCT TGGCGCACAACATATCTCCCATTCGCCCTCGAGGGCTGCCCTGAGTTCTGTCTCGTCCAAAATCCGGTGCCTTCC TCGGAAGTCTCGATTTCACTATTCCACAGTATATTATCATCGGCTGCATTCCACCTCCGGAACATCATGGGTGGT TCACGAGAATACCACAAACTTGGTCTCCAGCATCGGGCCAAAGCTTTACAAGCACTCAAGACTGCCCTCATAACG CCCAATGACTCTGAGAAATATACAGTCTATCTCACGGCAATGCTGGCCTTGGTCACAATCGATGTAGGTAGCTTT CGCTCCACGTTATAAAAAAGCTTATTAAATCTAACAAATCAGACAATGACGGGAGAAGATTCAGATTTTCCAATT CATCTCAAGGGTTGTCGTCAGCTGGAAAGACCAGGCCGTGCGTCCGATTCACCCAATGACTCCAGTCGGCAGGTT AGCAGTATTTGCCATTTCCTAAGCCTCCTGGCTCGAACGACAGCACACGAGCTAGAGCATAGACAATGGACAACA GAAGGTCCATTATTTGAGCAGCCTTACTTCCACGACGACGACACCAACATCCAATACATGTATGGGATTACCCCA TATCTGGGGAATCTTCTACAAAGGACCTGTCAGGTGGCCGAGTATTTAGCCTTCTACCAGGGTGCTGAAGTGCCA ACAATCTTGCTGGAGGCATGCTCGGCATTAAAAGATGAAATCTTTTCGTGGGATATAGACTCCGAGTCTTTCCAT CACGTCATGCTAGAGCAGCCGACGATGCTTGAGATAATACGTTGCCAGGCTCTATCATTTCACAGCGCGATCGCA ATTTTTTATTATCGAGCAATTGAAGACTCCAGCCCGGTGGATCTTCAGCAGCAAGTAGGGGCAATTTGGAAGAAC CTTTCGCTGGCAGAAGACCTTAAAGATGTATACTCAAGTGACGGAAAACGCGCAGCTCCTATGTCTTGGCCAGCA TTTATCGCTGCATGCGAGGCGATCGATCGACAACCTTGGGTTGAATGGTGGGAGCGAGTTCAGAGGTACTCAATG GGCAATTTCAAAAGGCAATGGAAAGTCATACAGGAAATCTGGAACATCATGGATTTAGATGAGAATGTGCTTAAC TGGAGAGATGCGCTCAAACAATCGGGCAAGTTGGTCTTGCCTATCTGA