Fungal Genomics

Agaricus bisporus var bisporus H39 Agaricus bisporus var bisporus H97 Agaricus bisporus var burnettii H119p4 Aspergillus niger CBS 112.32 Aspergillus niger CBS 113.50 Aspergillus niger CBS 115988 Aspergillus niger CBS 115989 Aspergillus niger CBS 118.52 Aspergillus niger CBS 124.48 Aspergillus niger CBS 131.52 Aspergillus niger CBS 133816 Aspergillus niger CBS 147320 Aspergillus niger CBS 147321 Aspergillus niger CBS 147322 Aspergillus niger CBS 147323 Aspergillus niger CBS 147324 Aspergillus niger CBS 147343 Aspergillus niger CBS 147344 Aspergillus niger CBS 147345 Aspergillus niger CBS 147346 Aspergillus niger CBS 147347 Aspergillus niger CBS 147352 Aspergillus niger CBS 147353 Aspergillus niger CBS 147371 Aspergillus niger CBS 147482 Aspergillus niger CBS 630.78 Aspergillus niger CBS 769.97 Niveomyces coronatus CBS 149186 Ophiocordyceps australis 1348a (Ghana) Ophiocordyceps australis map64 (Brazil) Ophiocordyceps camponoti-floridani Ophiocordyceps camponoti-rufipedis Ophiocordyceps kimflemingae Ophiocordyceps subramaniannii Penicillium roqueforti DTO002I6 Penicillium roqueforti DTO003C3 Penicillium roqueforti DTO003H1 (CBS 147308) Penicillium roqueforti DTO006G1 Penicillium roqueforti DTO006G7 Penicillium roqueforti DTO012A1 Penicillium roqueforti DTO012A2 (CBS 147309) Penicillium roqueforti DTO012A6 (CBS 147310) Penicillium roqueforti DTO012A7 Penicillium roqueforti DTO012A8 Penicillium roqueforti DTO012A9 Penicillium roqueforti DTO013E5 Penicillium roqueforti DTO013F2 Penicillium roqueforti DTO013F5 (CBS 147311) Penicillium roqueforti DTO027I6 Penicillium roqueforti DTO032C6 Penicillium roqueforti DTO039G3 Penicillium roqueforti DTO046C5 Penicillium roqueforti DTO070G2 (CBS 147317) Penicillium roqueforti DTO081F9 (CBS 147318) Penicillium roqueforti DTO101D6 (CBS 147325) Penicillium roqueforti DTO102I9 (CBS 147326) Penicillium roqueforti DTO126G2 (CBS 147330) Penicillium roqueforti DTO127F7 (CBS 147331) Penicillium roqueforti DTO127F9 (CBS 147332) Penicillium roqueforti DTO130C1 (CBS 147333) Penicillium roqueforti DTO163C3 (CBS 147337) Penicillium roqueforti DTO163F5 (CBS 147338) Penicillium roqueforti DTO163G4 (CBS 147339) Penicillium roqueforti DTO265D5 (CBS 147372) Penicillium roqueforti DTO369A1 (CBS 147354) Penicillium roqueforti DTO375B1 (CBS 147355) Penicillium roqueforti DTO377G2 (LCP 96.3914a) Penicillium roqueforti LCP96 04111 Rhodonia placenta FPRL280 Torrubiellomyces zombiae CBS 149187

General Properties

Protein ID	Pro_DTO377G3_2|g2098.t1
Gene name
Location	scaffold_02:1652926..1656603
Strand	-
Gene length (bp)	3677
Transcript length (bp)	3255
Coding sequence length (bp)	3255
Protein length (aa)	1085

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PFAM Domains

PFAM Domain ID	Short name	Long name	E-value	Start	End
PF07992	Pyr_redox_2	Pyridine nucleotide-disulphide oxidoreductase	1.4E-44	27	316
PF01077	NIR_SIR	Nitrite and sulphite reductase 4Fe-4S domain	9.0E-23	692	816
PF13806	Rieske_2	Rieske-like [2Fe-2S] domain	4.5E-16	913	1023
PF00070	Pyr_redox	Pyridine nucleotide-disulphide oxidoreductase	4.4E-15	176	259
PF00355	Rieske	Rieske [2Fe-2S] domain	1.7E-13	913	1010
PF04324	Fer2_BFD	BFD-like [2Fe-2S] binding domain	5.3E-12	479	527
PF03460	NIR_SIR_ferr	Nitrite/Sulfite reductase ferredoxin-like half domain	1.9E-10	619	680

GO

GO Term	Description	Terminal node
GO:0016491	oxidoreductase activity	Yes
GO:0051537	2 iron, 2 sulfur cluster binding	Yes
GO:0008942	nitrite reductase [NAD(P)H] activity	Yes
GO:0051536	iron-sulfur cluster binding	Yes
GO:0020037	heme binding	Yes
GO:0046906	tetrapyrrole binding	No
GO:0097159	organic cyclic compound binding	No
GO:0005488	binding	No
GO:0046857	oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor	No
GO:0051540	metal cluster binding	No
GO:1901363	heterocyclic compound binding	No
GO:0016661	oxidoreductase activity, acting on other nitrogenous compounds as donors	No
GO:0098809	nitrite reductase activity	No
GO:0003674	molecular_function	No
GO:0003824	catalytic activity	No

SignalP

[Help with interpreting these statistics]

SignalP signal predicted	Location (based on Ymax)	D score (significance: > 0.45)
No	1 - 42	0.45

Transmembrane Domains

(None)

Transcription Factor Class

(None)

Expression data

Analysis 1: Genome-wide gene expression in conidia of Penicillium roqueforti during growth at various temperatures and for various amounts of time. Published in Punt et al., 2020.

Expression values

Label	Description	Expression (RPKM)	Confidence interval (low)	Confidence interval (high)
3d_25C	Three days - 25 degrees Celsius	0.02	0.00	0.08
5d_25C	Five days - 25 degrees Celsius	0.13	0.00	0.30
7d_25C	Seven days - 25 degrees Celsius	0.52	0.02	1.01
10d_25C	Ten days - 25 degrees Celsius	0.25	0.00	0.52
7d_15C	Seven days - 15 degrees Celsius	0.32	0.00	0.66
7d_30C	Seven days - 30 degrees Celsius	0.02	0.00	0.08

Differential expression

Label1	Label2	Q-value	Significant difference
3d_25C	5d_25C	1.0	no
3d_25C	7d_25C	1.0	no
3d_25C	7d_15C	1.0	no
3d_25C	7d_30C	1.0	no
3d_25C	10d_25C	1.0	no
5d_25C	7d_25C	1.0	no
5d_25C	7d_15C	1.0	no
5d_25C	7d_30C	1.0	no
5d_25C	10d_25C	1.0	no
7d_25C	7d_15C	1.0	no
7d_25C	7d_30C	1.0	no
7d_25C	10d_25C	1.0	no
7d_15C	7d_30C	1.0	no
7d_15C	10d_25C	1.0	no
7d_30C	10d_25C	1.0	no

Sequences

Type of sequence	Sequence
Locus	Download genbank file of locus The gene with 5 kb flanks (if sufficient flanking sequence is available). For use in cloning design programs. NOTE: features (genes or exons) that are only partially contained within the sequence are completely excluded.
Protein	>Pro_DTO377G3_2|g2098.t1 MPVLDGLRYGEPVDGSPSPATHVQRQKIVVVGLGMVAISLIEKIIKQDTERKYDIVVIGEESHVAYNRVGLSSFF EHRKIEDLYLNPTEWYDSFKERSFDHHINTRVTAINPKEKTVQTSTGDTIAYDILVLATGSDATLPTHTPGYDAK GVFVYRTISDLERLIDFAAQHKGQTAVTVGGGLLGLEAAKAMTDLEDFGNVKLIDRNKWVLARQLDGDAGSLVTR KIQELGLDVLHQKRVKIVHTDEGNNVTGITFEDGESIDCCCICFAIGVQPRDELGRNIGIQCGERGGFVIDECLQ TSIPDIYAVGECASWENQTFGIIAPGIEMADVLAFNLTNPDKQPRGFTRPDLSTKLKLLGVDVASFGDFFADRDG PKFLPGRRPSTGPGLGGDTSLEEPPVKALTYKDPFSGVYKKYLFTMDGKFLLGGMMIGDTKDYLKLNQMVKLQKE LEVPPSQFILGAQNGGEENADDLDDSTQICSCHNVTKGDVADNVKNGTCTTIAQVKSCTKAGTGCGGCMPLVQSI FNKTMLEMGQEVSNHLCSHIPYSRADLYNIVAIKQLKTFVDIMKAVGKNPESLGCELCKPAIGSILSSLFNPHVM DKGINDLQDTNDKFLANIQRNGTFSVVPRIPGGEITADKLIAIGSVAKKYGLYCKITGAQRIDMFGAKKQDLLNI WTELVDAGMESGHAYAKALRAIKSCVGTTWCRFGVGDSVGMAIRLEERYKSIRAPHKFKGAVSGCVRECAEAQNK DFGLIATENGFNIFVGGNGGAKPRHAELLVTDVPAEMVMPIIDRYLIFYIRTADKLQRTARWIENLPGGIHYLKE VIVDDKLGICADMEKQMRELVDTYFCEWTETVKDPKRRKVFQQFANTDETVETVEVIQERSQQRPTYWPKDSAER EDFKGHKWSSVSWQPVVRADHFSDEPPQVSSANVKRGDTQLAIFKIKGKFYATQQMCPHKRAFVLSDGLVGDDDA GKYWVSCPYHKRNFELNGEQAGRCSNDESMNIATFPVEERDDGWVYVKLPPIEELDSILGTEKWKVRKSETEDPF HKVDKKFKGMKGKKVTDGFLTGVSAVQPAKSIDW*
Coding	>Pro_DTO377G3_2|g2098.t1 ATGCCTGTGCTGGATGGACTACGATATGGGGAGCCAGTCGATGGCAGCCCTAGTCCTGCAACTCATGTCCAGCGC CAGAAAATCGTAGTAGTTGGGCTGGGAATGGTGGCTATCTCACTCATCGAGAAGATTATTAAACAGGATACGGAG CGAAAATACGACATCGTTGTCATCGGCGAAGAGTCCCATGTAGCATACAACCGCGTCGGACTCTCGTCGTTTTTC GAGCATCGCAAGATTGAGGACTTATACCTCAATCCAACGGAATGGTATGACTCGTTCAAAGAACGATCCTTCGAT CACCACATCAACACACGAGTAACAGCAATCAATCCCAAGGAGAAAACTGTCCAAACCTCCACCGGTGACACTATA GCCTATGACATCCTCGTCCTCGCAACAGGCTCCGATGCAACTCTTCCAACACACACACCTGGTTACGATGCCAAA GGCGTCTTCGTATATCGAACTATCTCAGACTTGGAACGCCTCATCGACTTTGCTGCTCAGCATAAAGGCCAAACG GCTGTTACAGTCGGGGGCGGACTACTAGGCCTGGAAGCTGCGAAGGCGATGACAGACCTGGAGGATTTCGGAAAT GTCAAATTGATTGATCGGAATAAATGGGTCCTGGCGCGACAGCTAGACGGAGATGCAGGGTCCTTGGTCACTCGC AAGATCCAGGAGTTGGGACTTGATGTTCTCCATCAGAAACGGGTCAAGATTGTTCATACCGACGAGGGAAATAAT GTGACAGGGATTACTTTCGAGGATGGTGAGAGCATTGATTGTTGCTGTATTTGCTTTGCGATTGGAGTTCAACCT CGAGATGAGCTGGGTCGTAACATTGGGATCCAGTGTGGTGAGCGTGGAGGATTTGTGATCGATGAATGTCTGCAA ACTTCAATCCCAGATATCTACGCTGTCGGAGAATGCGCAAGCTGGGAGAACCAGACATTCGGAATCATTGCTCCC GGCATTGAGATGGCCGATGTGCTCGCCTTCAATCTGACCAACCCAGATAAACAGCCTAGGGGTTTCACGCGGCCG GACCTCAGCACAAAGTTGAAGCTTCTCGGAGTTGATGTCGCTAGTTTCGGTGACTTCTTTGCTGACAGAGATGGG CCGAAATTTCTTCCCGGTCGTCGACCTTCCACTGGCCCTGGTCTGGGAGGGGATACTTCACTAGAGGAGCCTCCT GTGAAGGCTTTGACATATAAGGACCCCTTTAGTGGAGTGTACAAGAAGTACTTGTTTACTATGGACGGCAAATTC TTGCTTGGTGGCATGATGATTGGAGATACCAAAGACTATCTGAAGTTGAATCAGATGGTTAAGCTTCAGAAAGAA CTCGAGGTTCCTCCAAGTCAATTCATCCTTGGTGCCCAAAATGGCGGGGAGGAAAATGCAGATGACCTTGATGAC AGCACTCAGATCTGTTCATGCCACAATGTCACCAAGGGAGATGTGGCCGATAATGTGAAGAATGGCACATGCACA ACCATTGCACAAGTCAAGTCATGCACGAAAGCAGGAACAGGCTGTGGAGGTTGCATGCCTCTTGTTCAGTCAATC TTCAACAAGACAATGCTTGAAATGGGACAAGAGGTATCAAACCACCTGTGTTCACATATTCCCTACTCCCGAGCC GATCTATACAACATCGTGGCCATCAAGCAACTGAAAACCTTTGTCGATATCATGAAAGCCGTCGGAAAGAACCCA GAATCTCTTGGTTGCGAACTTTGCAAGCCCGCAATTGGTTCCATTCTGTCTAGTTTGTTCAATCCGCACGTCATG GACAAGGGTATCAATGACTTGCAAGATACAAACGACAAGTTTCTGGCCAACATCCAAAGAAACGGCACATTCTCT GTGGTGCCCCGAATTCCAGGTGGTGAAATCACGGCCGATAAACTCATTGCTATCGGATCTGTAGCCAAGAAATAC GGTCTGTATTGCAAAATCACCGGTGCCCAGCGCATCGACATGTTCGGTGCGAAGAAGCAGGATCTTCTAAATATC TGGACGGAACTTGTGGATGCGGGTATGGAGAGCGGACACGCATATGCAAAGGCTCTTCGAGCAATCAAAAGTTGC GTTGGAACCACATGGTGTCGCTTCGGTGTTGGCGACAGTGTCGGCATGGCAATTCGACTGGAAGAGCGATACAAG AGCATTCGTGCGCCTCATAAATTCAAGGGAGCTGTATCTGGCTGCGTACGAGAGTGTGCCGAGGCCCAAAACAAA GACTTCGGGCTCATCGCCACCGAAAATGGGTTCAACATATTTGTTGGAGGCAACGGAGGTGCAAAACCTAGACAC GCCGAACTCCTTGTTACAGATGTGCCAGCGGAGATGGTGATGCCCATAATCGACCGCTACCTGATCTTCTATATC CGCACCGCCGACAAGCTCCAGCGAACAGCACGATGGATCGAAAATCTTCCGGGCGGAATCCACTACCTCAAAGAA GTGATCGTGGATGATAAACTTGGGATCTGCGCCGACATGGAAAAGCAAATGCGCGAACTAGTCGATACTTACTTC TGCGAGTGGACCGAGACCGTCAAAGACCCCAAGCGCCGAAAAGTCTTCCAACAATTTGCAAACACAGACGAAACG GTCGAGACGGTAGAAGTTATCCAAGAACGATCCCAGCAGCGACCCACATACTGGCCCAAGGACTCTGCCGAGCGA GAGGATTTCAAAGGCCACAAGTGGTCAAGTGTCTCCTGGCAGCCAGTTGTCCGAGCAGATCATTTCTCCGACGAG CCACCTCAGGTGTCATCGGCGAATGTCAAGCGCGGTGACACGCAGCTTGCTATCTTCAAGATCAAGGGCAAGTTC TATGCGACGCAGCAGATGTGCCCGCACAAACGAGCTTTTGTTCTTTCTGATGGCCTCGTTGGCGATGATGATGCT GGGAAATATTGGGTGTCGTGTCCGTATCACAAGCGCAACTTCGAGCTCAACGGTGAACAGGCGGGTCGTTGCTCA AATGATGAGAGTATGAATATTGCTACGTTCCCTGTTGAGGAGAGGGACGATGGCTGGGTATATGTCAAACTTCCG CCGATTGAGGAGTTGGATTCGATTTTGGGCACGGAGAAGTGGAAAGTGCGTAAGAGTGAGACGGAGGATCCTTTC CACAAGGTTGATAAGAAGTTCAAGGGTATGAAGGGGAAGAAGGTCACCGATGGCTTTTTGACTGGTGTATCAGCG GTGCAACCAGCCAAGTCCATTGATTGGTAG
Transcript	>Pro_DTO377G3_2|g2098.t1 ATGCCTGTGCTGGATGGACTACGATATGGGGAGCCAGTCGATGGCAGCCCTAGTCCTGCAACTCATGTCCAGCGC CAGAAAATCGTAGTAGTTGGGCTGGGAATGGTGGCTATCTCACTCATCGAGAAGATTATTAAACAGGATACGGAG CGAAAATACGACATCGTTGTCATCGGCGAAGAGTCCCATGTAGCATACAACCGCGTCGGACTCTCGTCGTTTTTC GAGCATCGCAAGATTGAGGACTTATACCTCAATCCAACGGAATGGTATGACTCGTTCAAAGAACGATCCTTCGAT CACCACATCAACACACGAGTAACAGCAATCAATCCCAAGGAGAAAACTGTCCAAACCTCCACCGGTGACACTATA GCCTATGACATCCTCGTCCTCGCAACAGGCTCCGATGCAACTCTTCCAACACACACACCTGGTTACGATGCCAAA GGCGTCTTCGTATATCGAACTATCTCAGACTTGGAACGCCTCATCGACTTTGCTGCTCAGCATAAAGGCCAAACG GCTGTTACAGTCGGGGGCGGACTACTAGGCCTGGAAGCTGCGAAGGCGATGACAGACCTGGAGGATTTCGGAAAT GTCAAATTGATTGATCGGAATAAATGGGTCCTGGCGCGACAGCTAGACGGAGATGCAGGGTCCTTGGTCACTCGC AAGATCCAGGAGTTGGGACTTGATGTTCTCCATCAGAAACGGGTCAAGATTGTTCATACCGACGAGGGAAATAAT GTGACAGGGATTACTTTCGAGGATGGTGAGAGCATTGATTGTTGCTGTATTTGCTTTGCGATTGGAGTTCAACCT CGAGATGAGCTGGGTCGTAACATTGGGATCCAGTGTGGTGAGCGTGGAGGATTTGTGATCGATGAATGTCTGCAA ACTTCAATCCCAGATATCTACGCTGTCGGAGAATGCGCAAGCTGGGAGAACCAGACATTCGGAATCATTGCTCCC GGCATTGAGATGGCCGATGTGCTCGCCTTCAATCTGACCAACCCAGATAAACAGCCTAGGGGTTTCACGCGGCCG GACCTCAGCACAAAGTTGAAGCTTCTCGGAGTTGATGTCGCTAGTTTCGGTGACTTCTTTGCTGACAGAGATGGG CCGAAATTTCTTCCCGGTCGTCGACCTTCCACTGGCCCTGGTCTGGGAGGGGATACTTCACTAGAGGAGCCTCCT GTGAAGGCTTTGACATATAAGGACCCCTTTAGTGGAGTGTACAAGAAGTACTTGTTTACTATGGACGGCAAATTC TTGCTTGGTGGCATGATGATTGGAGATACCAAAGACTATCTGAAGTTGAATCAGATGGTTAAGCTTCAGAAAGAA CTCGAGGTTCCTCCAAGTCAATTCATCCTTGGTGCCCAAAATGGCGGGGAGGAAAATGCAGATGACCTTGATGAC AGCACTCAGATCTGTTCATGCCACAATGTCACCAAGGGAGATGTGGCCGATAATGTGAAGAATGGCACATGCACA ACCATTGCACAAGTCAAGTCATGCACGAAAGCAGGAACAGGCTGTGGAGGTTGCATGCCTCTTGTTCAGTCAATC TTCAACAAGACAATGCTTGAAATGGGACAAGAGGTATCAAACCACCTGTGTTCACATATTCCCTACTCCCGAGCC GATCTATACAACATCGTGGCCATCAAGCAACTGAAAACCTTTGTCGATATCATGAAAGCCGTCGGAAAGAACCCA GAATCTCTTGGTTGCGAACTTTGCAAGCCCGCAATTGGTTCCATTCTGTCTAGTTTGTTCAATCCGCACGTCATG GACAAGGGTATCAATGACTTGCAAGATACAAACGACAAGTTTCTGGCCAACATCCAAAGAAACGGCACATTCTCT GTGGTGCCCCGAATTCCAGGTGGTGAAATCACGGCCGATAAACTCATTGCTATCGGATCTGTAGCCAAGAAATAC GGTCTGTATTGCAAAATCACCGGTGCCCAGCGCATCGACATGTTCGGTGCGAAGAAGCAGGATCTTCTAAATATC TGGACGGAACTTGTGGATGCGGGTATGGAGAGCGGACACGCATATGCAAAGGCTCTTCGAGCAATCAAAAGTTGC GTTGGAACCACATGGTGTCGCTTCGGTGTTGGCGACAGTGTCGGCATGGCAATTCGACTGGAAGAGCGATACAAG AGCATTCGTGCGCCTCATAAATTCAAGGGAGCTGTATCTGGCTGCGTACGAGAGTGTGCCGAGGCCCAAAACAAA GACTTCGGGCTCATCGCCACCGAAAATGGGTTCAACATATTTGTTGGAGGCAACGGAGGTGCAAAACCTAGACAC GCCGAACTCCTTGTTACAGATGTGCCAGCGGAGATGGTGATGCCCATAATCGACCGCTACCTGATCTTCTATATC CGCACCGCCGACAAGCTCCAGCGAACAGCACGATGGATCGAAAATCTTCCGGGCGGAATCCACTACCTCAAAGAA GTGATCGTGGATGATAAACTTGGGATCTGCGCCGACATGGAAAAGCAAATGCGCGAACTAGTCGATACTTACTTC TGCGAGTGGACCGAGACCGTCAAAGACCCCAAGCGCCGAAAAGTCTTCCAACAATTTGCAAACACAGACGAAACG GTCGAGACGGTAGAAGTTATCCAAGAACGATCCCAGCAGCGACCCACATACTGGCCCAAGGACTCTGCCGAGCGA GAGGATTTCAAAGGCCACAAGTGGTCAAGTGTCTCCTGGCAGCCAGTTGTCCGAGCAGATCATTTCTCCGACGAG CCACCTCAGGTGTCATCGGCGAATGTCAAGCGCGGTGACACGCAGCTTGCTATCTTCAAGATCAAGGGCAAGTTC TATGCGACGCAGCAGATGTGCCCGCACAAACGAGCTTTTGTTCTTTCTGATGGCCTCGTTGGCGATGATGATGCT GGGAAATATTGGGTGTCGTGTCCGTATCACAAGCGCAACTTCGAGCTCAACGGTGAACAGGCGGGTCGTTGCTCA AATGATGAGAGTATGAATATTGCTACGTTCCCTGTTGAGGAGAGGGACGATGGCTGGGTATATGTCAAACTTCCG CCGATTGAGGAGTTGGATTCGATTTTGGGCACGGAGAAGTGGAAAGTGCGTAAGAGTGAGACGGAGGATCCTTTC CACAAGGTTGATAAGAAGTTCAAGGGTATGAAGGGGAAGAAGGTCACCGATGGCTTTTTGACTGGTGTATCAGCG GTGCAACCAGCCAAGTCCATTGATTGGTAG
Gene	>Pro_DTO377G3_2|g2098.t1 ATGCCTGTGCTGGATGGACTACGATATGGGGAGCCAGTCGATGGCAGCCCTAGTCCTGCAACTCATGTCCAGCGC CAGAAAATCGTAGTAGTTGGGCTGGGAATGGTGGCTATCTCACTCATGTAAGGAAAATTCAACGACGGACATGAG AAATTTTCTAACAAAAACTAGCGAGAAGATTATTAAACAGGATACGGAGCGAAAATACGACATCGTTGTCATCGG CGAAGAGTCCCATGTAGCATACAACCGCGTCGGACTCTCGTCGTTTTTCGAGCATCGCAAGATTGAGGACTTATA CCTCAATCCAACGGAATGGGTAAGCCTTCACCTATTCGAGAGCGAAGAACATAAGACCTAATAAAAAAACACCTT ATTAGTATGACTCGTTCAAAGAACGATCCTTCGATCACCACATCAACACACGAGTAACAGCAATCAATCCCAAGG AGAAAACTGTCCAAACCTCCACCGGTGACACTATAGCCTATGACATCCTCGTCCTCGCAACAGGCTCCGATGCAA CTCTTCCAACACACACACCTGGTTACGATGCCAAAGGCGTCTTCGTATATCGAACTATCTCAGACTTGGAACGCC TCATCGACTTTGCTGCTCAGCATAAAGGCCAAACGGCTGTTACAGTCGGGGGCGGACTACTAGGCCTGGAAGCTG CGAAGGCGATGACAGACCTGGAGGATTTCGGAAATGTCAAATTGATTGATCGGAATAAATGGGTCCTGGCGCGAC AGCTAGACGGAGATGCAGGGTCCTTGGTCACTCGCAAGATCCAGGAGTTGGGACTTGATGTTCTCCATCAGAAAC GGGTCAAGATTGTTCATACCGACGAGGGAAATAATGTGACAGGGATTACTTTCGAGGATGGTGAGAGCATTGATT GTTGCTGTATTTGCTTTGCGGTATGTGTCCTTGTTTGCTTTCGTCTGATGATGGATGTGCTGATTCAGACTTAGA TTGGAGTTCAACCTCGAGATGAGCTGGGTCGTAACATTGGGATCCAGTGTGGTGAGCGTGGAGGATTTGTGATCG ATGAATGGTTCGTCCATTAACAGTCTTTTGGTCAGTCTCCAACTAACTTGCATAGTCTGCAAACTTCAATCCCAG ATATCTACGCTGTCGGAGAATGCGCAAGCTGGGAGAACCAGACATTCGGAATCATTGCTCCCGGCATTGAGATGG CCGATGTGCTCGCCTTCAATCTGACCAACCCAGATAAACAGCCTAGGGGTTTCACGCGGCCGGACCTCAGCACAA AGTTGAAGCTTCTCGGAGTTGATGTCGCTAGTTTCGGTGACTTCTTTGCTGACAGAGATGGGCCGAAATTTCTTC CCGGTCGTCGACCTTCCACTGGCCCTGGTCTGGGAGGGGATACTTCACTAGAGGAGCCTCCTGTGAAGGCTTTGA CATATAAGGACCCCTTTAGTGGAGTGTACAAGAAGTACTTGTTTACTATGGACGGCAAATTCTTGCTTGGTGGCA TGATGATTGGAGATACCAAAGACTATCTGAAGTTGAATCAGATGGTTAAGCTTCAGAAAGAACTCGAGGTTCCTC CAAGTCAATTCATCCTTGGTGCCCAAAATGGCGGGGAGGAAAATGCAGATGACCTGTGAGTATCGTTAGTTCTGC TATTGGGGAGAAATTCTAACTCATCTCTGCAGTGATGACAGCACTCAGATCTGTTCATGCCACAATGTCACCAAG GGAGATGTGGCCGATAATGTGAAGAATGGCACATGCACAACCATTGCACAAGTCAAGTCATGCACGAAAGCAGGA ACAGGCTGTGGAGGTTGCATGCCTCTTGTTCAGTCAATCTTCAACAAGACAATGCTTGAAATGGGACAAGAGGTA TCAAACCACCGTAAGTAATATCAACTTTCTCCAGTGCTAGCTCCTGTCATCATTAACATTTTCAGTGTGTTCACA TATTCCCTACTCCCGAGCCGATCTATACAACATCGTGGCCATCAAGCAACTGAAAACCTTTGTCGATATCATGAA AGCCGTCGGAAAGAACCCAGAATCTCTTGGTTGCGAACTTTGCAAGCCCGCAATTGGTTCCATTCTGTCTAGTTT GTTCAATCCGCACGTCATGGACAAGGGTATCAATGACTTGCAAGATACAAACGACAAGTTTCTGGCCAACATCCA AAGAAACGGCACATTCTCTGTGGTGCCCCGAATTCCAGGTGGTGAAATCACGGCCGATAAACTCATTGCTATCGG ATCTGTAGCCAAGAAATACGGTCTGTATTGCAAAATCACCGGTGCCCAGCGCATCGACATGTTCGGTGCGAAGAA GCAGGATCTTCTAAATATCTGGACGGAACTTGTGGATGCGGGTATGGAGAGCGGACACGCATATGCAAAGGCTCT TCGAGCAATCAAAGTACGTGGAGCAATTATCTTCAAGAGAGTACCAACTGACAGTGAACGTTCAGAGTTGCGTTG GAACCACATGGTGTCGCTTCGGTGTTGGCGACAGTGTCGGCATGGCAATTCGACTGGAAGAGCGATACAAGAGCA TTCGTGCGCCTCATAAATTCAAGGGAGCTGTATCTGGCTGCGTACGAGAGTGTGCCGAGGCCCAAAACAAAGAGT GAGTGCAAATCCTACGCTGGTGAAAACACTCAGGACTAATAGTTGCCAGCTTCGGGCTCATCGCCACCGAAAATG GGTTCAACATATTTGTTGGAGGCAACGGAGGTGCAAAACCTAGACACGCCGAACTCCTTGTTACAGATGTGCCAG CGGAGATGGTGATGCCCATAATCGACCGCTACCTGATCTTCTATATCCGCACCGCCGACAAGCTCCAGCGAACAG CACGATGGATCGAAAATCTTCCGGGCGGAATCCACTACCTCAAAGAAGTGATCGTGGATGATAAACTTGGGATCT GCGCCGACATGGAAAAGCAAATGCGCGAACTAGTCGATACTTACTTCTGCGAGTGGACCGAGACCGTCAAAGACC CCAAGCGCCGAAAAGTCTTCCAACAATTTGCAAACACAGACGAAACGGTCGAGACGGTAGAAGTTATCCAAGAAC GATCCCAGCAGCGACCCACATACTGGCCCAAGGACTCTGCCGAGCGAGAGGATTTCAAAGGCCACAAGTGGTCAA GTGTCTCCTGGCAGCCAGTTGTCCGAGCAGATCATTTCTCCGACGAGCCACCTCAGGTGTCATCGGCGAATGTCA AGCGCGGTGACACGCAGCTTGCTATCTTCAAGATCAAGGGCAAGTTCTATGCGACGCAGCAGATGTGCCCGCACA AACGAGCTTTTGTTCTTTCTGATGGCCTCGTTGGCGATGATGATGCTGGGAAATATTGGGTGTCGTGTCCGTATC ACAAGCGCAACTTCGAGCTCAACGGTGAACAGGCGGGTCGTTGCTCAAATGATGAGAGTATGAATATTGCTACGT TCCCTGTTGAGGAGAGGGACGATGGCTGGGTATATGTCAAACTTCCGCCGATTGAGGAGTTGGATTCGATTTTGG GCACGGAGAAGTGGAAAGTGCGTAAGAGTGAGACGGAGGATCCTTTCCACAAGGTTGATAAGAAGTTCAAGGGTA TGAAGGGGAAGAAGGTCACCGATGGCTTTTTGACTGGTGTATCAGCGGTGCAACCAGCCAAGTCCATTGATTGGT AG