Fungal Genomics

Agaricus bisporus var bisporus H39 Agaricus bisporus var bisporus H97 Agaricus bisporus var burnettii H119p4 Aspergillus niger CBS 112.32 Aspergillus niger CBS 113.50 Aspergillus niger CBS 115988 Aspergillus niger CBS 115989 Aspergillus niger CBS 118.52 Aspergillus niger CBS 124.48 Aspergillus niger CBS 131.52 Aspergillus niger CBS 133816 Aspergillus niger CBS 147320 Aspergillus niger CBS 147321 Aspergillus niger CBS 147322 Aspergillus niger CBS 147323 Aspergillus niger CBS 147324 Aspergillus niger CBS 147343 Aspergillus niger CBS 147344 Aspergillus niger CBS 147345 Aspergillus niger CBS 147346 Aspergillus niger CBS 147347 Aspergillus niger CBS 147352 Aspergillus niger CBS 147353 Aspergillus niger CBS 147371 Aspergillus niger CBS 147482 Aspergillus niger CBS 630.78 Aspergillus niger CBS 769.97 Ophiocordyceps australis 1348a (Ghana) Ophiocordyceps australis map64 (Brazil) Ophiocordyceps camponoti-floridani Ophiocordyceps camponoti-rufipedis Ophiocordyceps kimflemingae Ophiocordyceps subramaniannii Penicillium roqueforti DTO002I6 Penicillium roqueforti DTO003C3 Penicillium roqueforti DTO003H1 (CBS 147308) Penicillium roqueforti DTO006G1 Penicillium roqueforti DTO006G7 Penicillium roqueforti DTO012A1 Penicillium roqueforti DTO012A2 (CBS 147309) Penicillium roqueforti DTO012A6 (CBS 147310) Penicillium roqueforti DTO012A7 Penicillium roqueforti DTO012A8 Penicillium roqueforti DTO012A9 Penicillium roqueforti DTO013E5 Penicillium roqueforti DTO013F2 Penicillium roqueforti DTO013F5 (CBS 147311) Penicillium roqueforti DTO027I6 Penicillium roqueforti DTO032C6 Penicillium roqueforti DTO039G3 Penicillium roqueforti DTO046C5 Penicillium roqueforti DTO070G2 (CBS 147317) Penicillium roqueforti DTO081F9 (CBS 147318) Penicillium roqueforti DTO101D6 (CBS 147325) Penicillium roqueforti DTO102I9 (CBS 147326) Penicillium roqueforti DTO126G2 (CBS 147330) Penicillium roqueforti DTO127F7 (CBS 147331) Penicillium roqueforti DTO127F9 (CBS 147332) Penicillium roqueforti DTO130C1 (CBS 147333) Penicillium roqueforti DTO163C3 (CBS 147337) Penicillium roqueforti DTO163F5 (CBS 147338) Penicillium roqueforti DTO163G4 (CBS 147339) Penicillium roqueforti DTO265D5 (CBS 147372) Penicillium roqueforti DTO369A1 (CBS 147354) Penicillium roqueforti DTO375B1 (CBS 147355) Penicillium roqueforti DTO377G2 (LCP 96.3914a) Penicillium roqueforti LCP96 04111 Rhodonia placenta FPRL280

General Properties

Protein ID	Pro_DTO377G3_2|g2088.t1
Gene name
Location	scaffold_02:1629734..1633445
Strand	+
Gene length (bp)	3711
Transcript length (bp)	3159
Coding sequence length (bp)	3159
Protein length (aa)	1053

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PFAM Domains

PFAM Domain ID	Short name	Long name	E-value	Start	End
PF13424	TPR_12	Tetratricopeptide repeat	2.8E-10	926	985
PF13374	TPR_10	Tetratricopeptide repeat	5.0E-04	825	855
PF00931	NB-ARC	NB-ARC domain	8.5E-09	349	553

GO

GO Term	Description	Terminal node
GO:0043531	ADP binding	Yes
GO:0097367	carbohydrate derivative binding	No
GO:0017076	purine nucleotide binding	No
GO:0032555	purine ribonucleotide binding	No
GO:1901265	nucleoside phosphate binding	No
GO:0097159	organic cyclic compound binding	No
GO:0032553	ribonucleotide binding	No
GO:0005488	binding	No
GO:0043167	ion binding	No
GO:0000166	nucleotide binding	No
GO:0043168	anion binding	No
GO:1901363	heterocyclic compound binding	No
GO:0032559	adenyl ribonucleotide binding	No
GO:0003674	molecular_function	No
GO:0030554	adenyl nucleotide binding	No
GO:0036094	small molecule binding	No

SignalP

[Help with interpreting these statistics]

SignalP signal predicted	Location (based on Ymax)	D score (significance: > 0.45)
No	1 - 67	0.45

Transmembrane Domains

(None)

Transcription Factor Class

(None)

Expression data

Analysis 1: Genome-wide gene expression in conidia of Penicillium roqueforti during growth at various temperatures and for various amounts of time. Published in Punt et al., 2020.

Expression values

Label	Description	Expression (RPKM)	Confidence interval (low)	Confidence interval (high)
3d_25C	Three days - 25 degrees Celsius	0.39	0.00	0.78
5d_25C	Five days - 25 degrees Celsius	0.93	0.15	1.72
7d_25C	Seven days - 25 degrees Celsius	1.34	0.28	2.40
10d_25C	Ten days - 25 degrees Celsius	1.03	0.12	1.95
7d_15C	Seven days - 15 degrees Celsius	4.51	1.56	7.45
7d_30C	Seven days - 30 degrees Celsius	1.78	0.45	3.11

Differential expression

Label1	Label2	Q-value	Significant difference
3d_25C	5d_25C	0.106191	no
3d_25C	7d_25C	0.020393	yes
3d_25C	7d_15C	0.000700	yes
3d_25C	7d_30C	0.001804	yes
3d_25C	10d_25C	0.078956	no
5d_25C	7d_25C	0.485456	no
5d_25C	7d_15C	0.000700	yes
5d_25C	7d_30C	0.163055	no
5d_25C	10d_25C	0.889433	no
7d_25C	7d_15C	0.001804	yes
7d_25C	7d_30C	0.597973	no
7d_25C	10d_25C	0.662907	no
7d_15C	7d_30C	0.015833	yes
7d_15C	10d_25C	0.001278	yes
7d_30C	10d_25C	0.295940	no

Sequences

Type of sequence	Sequence
Locus	Download genbank file of locus The gene with 5 kb flanks (if sufficient flanking sequence is available). For use in cloning design programs. NOTE: features (genes or exons) that are only partially contained within the sequence are completely excluded.
Protein	>Pro_DTO377G3_2|g2088.t1 MIAPLSVVYDGVRKPEIDLVSIPGLPTIHPTYKLKDHTKWLREVLSHQVPQARIMAFQYDFAKDSMEVSWAELFR NVEYLLYSLVHRREGTEDRPVLFICYSFGAIILKKALLIAKKTPIFRNILDKTRGIIFLGCLNDESNPQIEELCL KCAAVELGVIMKNKMIDTLRKTDDWTIIRDVIESFRVLRCRFPVRNLYELRPTNIMSRTLGVKKVKREMLCDLRV SSLGWSDEDCVGIEKDHGELTMYPLRSDEDGYFETFMRTLTRMIDEIVPRPTQQAWERNDPDDDQNWLVMEGTSS NRSANLEADITKSMLSYNDSASFHTSHGTHIPCYVMTPFEDNPNFVGREKTLTAIHDALAPGSPSVGQRVFALTG LGGMGKTQTAVRYAFSQMEVTYKIVLWAHADGQSKLSESFSLFASELGLGDGLTHAKAKQAVKDYLAIVDVDWLM IFDNADGDDKTELLAEFWPRGDKGSILITSRDKTLTNRYHGRFLKELHSKNAVDLLLKLTGMPTTTTEERLAARE IVKRVGFLPLGINQAANLIINLSCTFSEFLGAYDLQELIEDSSDVQLISGGSYKYSLRTVWNMNFEKLSSADQAL LKMISFLDPDRIQMKLLLEGGAESANPNLHFINTSYKVTKCRAGLLRSSLISQNERKDELQMHRLVQAYCQLKVS PEEAQQSFGNAISLVKQVWPVPPRSEVHNPSLWERQRALLPHVQKLYVVNWDFPSVVYEASWFCYESGMLESVSD LLNPAKDYCIQHLASGRGYRLLADIYGCFGSLCTESNQFQGAYDNFATEWKYLEKAFEAGELERPSIWEVFGLGR LGNGHHGLHQYAEAEAYYRKALAAWENLPGDKKLWHSHLATCLWLQGRPDEGEVVVRGVIKDENDTTNFRTAMAM YALGNIQIAQATGLTLEGKKKDAEDKLAEAMNTHVKVLNLWTKTLGPRHHKTSDAMYKVGWHLHRRQEYAQALDM FERALDIYESQPHLYKNEIARTKYKIGCLKQDTQHHSDGAALIREADRIRQQIVPPEDWEPAKCEEDFDNIVQFW TR*
Coding	>Pro_DTO377G3_2|g2088.t1 ATGATTGCTCCCCTTTCGGTTGTCTACGACGGTGTCAGAAAGCCTGAGATTGACCTTGTCTCAATTCCGGGCCTT CCAACTATCCATCCTACGTACAAGTTGAAAGACCACACGAAATGGCTTCGGGAAGTACTGAGCCATCAGGTGCCC CAAGCGCGAATCATGGCATTTCAGTATGATTTTGCAAAGGATTCAATGGAAGTCTCCTGGGCGGAACTATTTCGA AATGTTGAATACCTACTATACAGTTTGGTACATCGGCGCGAGGGCACAGAAGACCGGCCTGTCTTATTCATCTGC TACAGCTTTGGGGCAATCATCCTCAAGAAGGCTTTGTTGATCGCAAAGAAAACCCCGATATTCCGAAACATTCTC GACAAGACCAGGGGTATCATATTCCTTGGCTGTCTGAACGATGAATCAAATCCACAAATCGAGGAGCTATGTCTT AAATGCGCTGCGGTGGAGCTAGGAGTGATCATGAAGAACAAGATGATCGACACCCTGCGAAAAACGGACGATTGG ACAATAATTCGAGACGTGATAGAGAGCTTCCGCGTTTTGAGATGCCGGTTCCCGGTACGCAACCTCTACGAACTC AGGCCGACTAACATTATGAGCCGTACACTCGGAGTCAAGAAAGTAAAGCGAGAAATGCTATGCGATTTACGGGTA TCGTCCTTAGGTTGGTCTGATGAGGATTGCGTGGGCATTGAAAAGGATCATGGGGAACTCACAATGTATCCACTC AGAAGCGATGAAGATGGATATTTCGAGACATTTATGCGCACACTCACGAGAATGATCGATGAGATTGTCCCAAGG CCAACGCAACAAGCATGGGAAAGAAATGATCCCGACGACGACCAAAACTGGCTTGTGATGGAAGGAACTTCTAGC AACCGGTCTGCGAATCTGGAGGCTGATATCACAAAGTCGATGTTGTCGTATAACGACTCAGCTTCATTTCACACA TCACATGGTACTCATATACCATGTTATGTCATGACCCCGTTTGAAGATAATCCCAATTTCGTTGGAAGAGAAAAA ACTCTCACTGCCATACACGATGCCTTGGCCCCAGGTAGTCCTAGCGTCGGACAAAGGGTATTCGCACTTACAGGC TTAGGCGGAATGGGGAAAACCCAGACAGCAGTACGTTATGCCTTTTCACAGATGGAAGTGACCTACAAGATTGTG CTATGGGCACACGCAGACGGGCAGTCCAAACTTTCAGAGAGCTTCTCTCTTTTCGCTTCCGAGCTGGGTCTGGGA GATGGATTGACCCACGCAAAAGCCAAGCAAGCGGTCAAAGACTACCTCGCGATTGTCGATGTGGACTGGCTCATG ATTTTTGACAATGCTGATGGTGATGATAAGACGGAACTGCTAGCAGAATTTTGGCCCCGAGGTGACAAAGGGTCT ATACTAATCACTAGCCGCGACAAAACTTTGACAAATCGGTACCATGGGAGATTCTTAAAGGAGCTTCATTCAAAA AACGCCGTGGATCTTCTGCTGAAACTCACTGGAATGCCCACCACTACCACAGAAGAGAGACTTGCAGCCCGCGAA ATTGTCAAGAGAGTAGGCTTCCTACCACTAGGAATAAACCAGGCTGCAAATTTGATCATAAATCTCTCATGCACT TTCTCCGAATTCCTTGGAGCATACGACTTGCAAGAGCTCATTGAAGACTCGTCTGATGTCCAGCTCATATCGGGG GGTTCTTACAAGTACTCGCTTCGAACGGTTTGGAACATGAACTTCGAGAAGCTTAGTAGTGCGGACCAAGCTCTG CTGAAGATGATCTCGTTTCTTGACCCCGATCGCATTCAAATGAAGTTGCTCCTGGAAGGAGGAGCAGAGAGCGCG AATCCAAACCTGCACTTCATTAATACTTCTTACAAAGTGACCAAATGCCGGGCAGGGCTTTTGCGCAGCTCTCTG ATCTCGCAAAATGAACGAAAAGATGAGCTTCAGATGCATCGTCTCGTACAAGCATACTGCCAACTCAAAGTGTCA CCAGAAGAAGCACAACAAAGTTTTGGCAATGCAATCTCGCTCGTGAAACAAGTCTGGCCAGTCCCGCCTCGATCA GAGGTGCATAATCCATCTTTATGGGAGAGACAAAGAGCTCTTCTGCCACATGTTCAAAAGTTATACGTCGTGAAT TGGGACTTTCCTTCCGTGGTATACGAGGCAAGCTGGTTCTGCTACGAGAGTGGGATGCTAGAGTCTGTTTCAGAC TTGCTGAATCCCGCGAAGGATTACTGTATCCAACATTTGGCTTCTGGAAGGGGTTATCGCCTGTTGGCAGATATA TATGGGTGCTTCGGATCTCTATGCACAGAGTCAAACCAATTTCAAGGCGCCTACGATAACTTCGCCACTGAATGG AAATATCTCGAGAAAGCTTTCGAAGCAGGGGAGCTTGAAAGACCAAGTATTTGGGAAGTCTTTGGTTTAGGGAGG CTTGGAAACGGGCACCATGGGCTGCATCAATATGCAGAAGCAGAAGCATACTATCGAAAGGCATTGGCCGCCTGG GAAAATCTTCCAGGTGATAAGAAGCTCTGGCACAGTCATCTTGCAACGTGTTTGTGGTTACAAGGTCGCCCAGAT GAAGGAGAGGTAGTCGTGCGAGGAGTCATCAAAGACGAAAATGACACAACCAATTTCAGAACTGCAATGGCAATG TATGCACTAGGCAATATTCAAATTGCCCAAGCTACAGGTTTGACACTCGAAGGAAAGAAAAAGGACGCCGAAGAT AAGCTAGCTGAGGCAATGAATACCCATGTCAAAGTACTCAATTTGTGGACGAAGACATTGGGACCAAGACACCAC AAGACCTCGGATGCAATGTACAAGGTCGGCTGGCATTTGCACAGACGCCAGGAATATGCCCAGGCATTGGACATG TTCGAGAGAGCGTTGGATATCTATGAAAGTCAGCCGCATCTATACAAAAACGAAATTGCCCGAACGAAATACAAG ATAGGCTGCCTGAAGCAGGATACACAGCATCATAGTGACGGTGCAGCTTTGATCCGCGAAGCGGACCGAATCAGA CAGCAGATAGTGCCGCCAGAAGACTGGGAGCCTGCGAAGTGCGAGGAGGACTTTGACAATATAGTCCAGTTCTGG ACACGATAA
Transcript	>Pro_DTO377G3_2|g2088.t1 ATGATTGCTCCCCTTTCGGTTGTCTACGACGGTGTCAGAAAGCCTGAGATTGACCTTGTCTCAATTCCGGGCCTT CCAACTATCCATCCTACGTACAAGTTGAAAGACCACACGAAATGGCTTCGGGAAGTACTGAGCCATCAGGTGCCC CAAGCGCGAATCATGGCATTTCAGTATGATTTTGCAAAGGATTCAATGGAAGTCTCCTGGGCGGAACTATTTCGA AATGTTGAATACCTACTATACAGTTTGGTACATCGGCGCGAGGGCACAGAAGACCGGCCTGTCTTATTCATCTGC TACAGCTTTGGGGCAATCATCCTCAAGAAGGCTTTGTTGATCGCAAAGAAAACCCCGATATTCCGAAACATTCTC GACAAGACCAGGGGTATCATATTCCTTGGCTGTCTGAACGATGAATCAAATCCACAAATCGAGGAGCTATGTCTT AAATGCGCTGCGGTGGAGCTAGGAGTGATCATGAAGAACAAGATGATCGACACCCTGCGAAAAACGGACGATTGG ACAATAATTCGAGACGTGATAGAGAGCTTCCGCGTTTTGAGATGCCGGTTCCCGGTACGCAACCTCTACGAACTC AGGCCGACTAACATTATGAGCCGTACACTCGGAGTCAAGAAAGTAAAGCGAGAAATGCTATGCGATTTACGGGTA TCGTCCTTAGGTTGGTCTGATGAGGATTGCGTGGGCATTGAAAAGGATCATGGGGAACTCACAATGTATCCACTC AGAAGCGATGAAGATGGATATTTCGAGACATTTATGCGCACACTCACGAGAATGATCGATGAGATTGTCCCAAGG CCAACGCAACAAGCATGGGAAAGAAATGATCCCGACGACGACCAAAACTGGCTTGTGATGGAAGGAACTTCTAGC AACCGGTCTGCGAATCTGGAGGCTGATATCACAAAGTCGATGTTGTCGTATAACGACTCAGCTTCATTTCACACA TCACATGGTACTCATATACCATGTTATGTCATGACCCCGTTTGAAGATAATCCCAATTTCGTTGGAAGAGAAAAA ACTCTCACTGCCATACACGATGCCTTGGCCCCAGGTAGTCCTAGCGTCGGACAAAGGGTATTCGCACTTACAGGC TTAGGCGGAATGGGGAAAACCCAGACAGCAGTACGTTATGCCTTTTCACAGATGGAAGTGACCTACAAGATTGTG CTATGGGCACACGCAGACGGGCAGTCCAAACTTTCAGAGAGCTTCTCTCTTTTCGCTTCCGAGCTGGGTCTGGGA GATGGATTGACCCACGCAAAAGCCAAGCAAGCGGTCAAAGACTACCTCGCGATTGTCGATGTGGACTGGCTCATG ATTTTTGACAATGCTGATGGTGATGATAAGACGGAACTGCTAGCAGAATTTTGGCCCCGAGGTGACAAAGGGTCT ATACTAATCACTAGCCGCGACAAAACTTTGACAAATCGGTACCATGGGAGATTCTTAAAGGAGCTTCATTCAAAA AACGCCGTGGATCTTCTGCTGAAACTCACTGGAATGCCCACCACTACCACAGAAGAGAGACTTGCAGCCCGCGAA ATTGTCAAGAGAGTAGGCTTCCTACCACTAGGAATAAACCAGGCTGCAAATTTGATCATAAATCTCTCATGCACT TTCTCCGAATTCCTTGGAGCATACGACTTGCAAGAGCTCATTGAAGACTCGTCTGATGTCCAGCTCATATCGGGG GGTTCTTACAAGTACTCGCTTCGAACGGTTTGGAACATGAACTTCGAGAAGCTTAGTAGTGCGGACCAAGCTCTG CTGAAGATGATCTCGTTTCTTGACCCCGATCGCATTCAAATGAAGTTGCTCCTGGAAGGAGGAGCAGAGAGCGCG AATCCAAACCTGCACTTCATTAATACTTCTTACAAAGTGACCAAATGCCGGGCAGGGCTTTTGCGCAGCTCTCTG ATCTCGCAAAATGAACGAAAAGATGAGCTTCAGATGCATCGTCTCGTACAAGCATACTGCCAACTCAAAGTGTCA CCAGAAGAAGCACAACAAAGTTTTGGCAATGCAATCTCGCTCGTGAAACAAGTCTGGCCAGTCCCGCCTCGATCA GAGGTGCATAATCCATCTTTATGGGAGAGACAAAGAGCTCTTCTGCCACATGTTCAAAAGTTATACGTCGTGAAT TGGGACTTTCCTTCCGTGGTATACGAGGCAAGCTGGTTCTGCTACGAGAGTGGGATGCTAGAGTCTGTTTCAGAC TTGCTGAATCCCGCGAAGGATTACTGTATCCAACATTTGGCTTCTGGAAGGGGTTATCGCCTGTTGGCAGATATA TATGGGTGCTTCGGATCTCTATGCACAGAGTCAAACCAATTTCAAGGCGCCTACGATAACTTCGCCACTGAATGG AAATATCTCGAGAAAGCTTTCGAAGCAGGGGAGCTTGAAAGACCAAGTATTTGGGAAGTCTTTGGTTTAGGGAGG CTTGGAAACGGGCACCATGGGCTGCATCAATATGCAGAAGCAGAAGCATACTATCGAAAGGCATTGGCCGCCTGG GAAAATCTTCCAGGTGATAAGAAGCTCTGGCACAGTCATCTTGCAACGTGTTTGTGGTTACAAGGTCGCCCAGAT GAAGGAGAGGTAGTCGTGCGAGGAGTCATCAAAGACGAAAATGACACAACCAATTTCAGAACTGCAATGGCAATG TATGCACTAGGCAATATTCAAATTGCCCAAGCTACAGGTTTGACACTCGAAGGAAAGAAAAAGGACGCCGAAGAT AAGCTAGCTGAGGCAATGAATACCCATGTCAAAGTACTCAATTTGTGGACGAAGACATTGGGACCAAGACACCAC AAGACCTCGGATGCAATGTACAAGGTCGGCTGGCATTTGCACAGACGCCAGGAATATGCCCAGGCATTGGACATG TTCGAGAGAGCGTTGGATATCTATGAAAGTCAGCCGCATCTATACAAAAACGAAATTGCCCGAACGAAATACAAG ATAGGCTGCCTGAAGCAGGATACACAGCATCATAGTGACGGTGCAGCTTTGATCCGCGAAGCGGACCGAATCAGA CAGCAGATAGTGCCGCCAGAAGACTGGGAGCCTGCGAAGTGCGAGGAGGACTTTGACAATATAGTCCAGTTCTGG ACACGATAA
Gene	>Pro_DTO377G3_2|g2088.t1 ATGATTGCTCCCCTTTCGGTTGTCTACGACGGTGTCAGAAAGCCTGAGATTGAGTAAGTTCTCCTCTGTTAGAAA AGACGTTTTGTCGAATAAACTAAATAAAATAATAATAGCCTTGTCTCAATTCCGGGCCTTCCAACTATCCATCCT ACGTACAAGTTGAAAGACCACACGAAATGGCTTCGGGAAGTACTGAGCCATCAGGTGCCCCAAGCGCGAATCATG GCATTTCAGTATGATTTTGCAAAGGATTCAATGGAAGTCTCCTGGGCGGAACTATTTCGAAATGTTGAATACCTA CTATACAGTTTGGTACATCGGCGCGAGGGCACAGAAGACCGGCCTGTCTTATTCATCTGCTACAGCTTTGGGGCA ATCATCCTCAAGAAGGCAAGTCACAAGTAGATTATTTATTCCACCTCCATAATTCGTAGCTAACATTATGTATTT CTTGATCAAGGCTTTGTTGATCGCAAAGAAAACCCCGATATTCCGAAACATTCTCGACAAGACCAGGGGTATCAT ATTCCTTGGCTGTCTGAACGATGAATCAAATCCACAAATCGAGGAGCTATGTCTTAAATGCGCTGCGGTGGAGCT AGGAGTGATCATGAAGAACAAGATGATCGACACCCTGCGAAAAACGGACGATTGGACAATAATTCGAGACGTGAT AGAGAGCTTCCGCGTTTTGAGATGCCGGTTCCCGGTACGCAACCTCTACGAACTCAGGCCGACTAACATTATGAG CCGTACACTCGGAGTCAAGAAAGTAAAGCGAGAAATGGTAGCTTTCACCCGAGATTAAGTGTCCAGGTTGATGAA GCTGATGAGCTAACATTGGTCAAAGCTATGCGATTTACGGGTATCGTCCTTAGGTTGGTCTGATGAGGATTGCGT GGGCATTGAAAAGGATCATGGGGAACTCACAATGTATCCACTCAGAAGCGATGAAGATGGATATTTCGAGACATT TATGCGCACACTCACGAGAATGATCGATGAGATTGTCCCAAGGCCAACGCAACAAGCATGGGAAAGAAATGATCC CGACGACGACCAAAACTGGCTTGTGATGGAAGGAACTTCTAGCAACCGGTCTGCGAATCTGGAGGGTATGTTAAC CCTCAAACCATGTTATTTTCAATATCTTATCTGACATATTTATCTCCCTGCTACCTTTAGCTGATATCACAAAGT CGATGTTGTCGTATAACGACTCAGCTTCATTTCACACATCACATGGTACTCATATACCATGTTATGTCATGACCC CGTTTGAAGATAATCCCAATTTCGTTGGAAGAGAAAAAACTCTCACTGCCATACACGATGCCTTGGCCCCAGGTA GTCCTAGCGTCGGACAAAGGGTATTCGCACTTACAGGCTTAGGCGGAATGGGGAAAACCCAGACAGCAGTACGTT ATGCCTTTTCACAGATGGAAGTGACCTACAAGATTGTGCTATGGGCACACGCAGACGGGCAGTCCAAACTTTCAG AGAGCTTCTCTCTTTTCGCTTCCGAGCTGGGTCTGGGAGATGGATTGACCCACGCAAAAGCCAAGCAAGCGGTCA AAGACTACCTCGCGATTGTCGGTAGGAGCTATCAATTGAAACCACTATTGATTCTGATCTGACCCTTAATCTAGA TGTGGACTGGCTCATGATTTTTGACAATGCTGATGGTGATGATAAGACGGAACTGCTAGCAGAATTTTGGCCCCG AGGTGACAAAGGGTCTATACTAATCACTAGCCGCGACAAAACTTTGACAAATCGGTACCATGGGAGATTCTTAAA GGAGCTTCATTCAAAAAACGCCGTGGATCTTCTGCTGAAACTCACTGGAATGCCCACCACTACCACAGAAGAGAG ACTTGCAGCCCGCGAAATTGTCAAGAGAGTAGGCTTCCTACCACTAGGAATAAACCAGGCTGCAAATTTGATCAT AAATCTCTCATGCACTTTCTCCGAATTCCTTGGAGCATACGACTTGCAAGAGCTCATTGAAGACTCGTCTGATGT CCAGCTCATATCGGGGGGTTCTTACAAGTACTCGCTTCGAACGGTTTGGAACATGAACTTCGAGAAGCTTAGTAG TGCGGACCAAGCTCTGCTGAAGATGATCTCGTTTCTTGACCCCGATCGCATTCAAATGAAGTTGCTCCTGGAAGG AGGAGCAGAGAGCGCGAATCCAAACCTGCACTTCATTAATACTTCTTACAAAGTGACCAAATGCCGGGCAGGGCT TTTGCGCAGCTCTCTGATCTCGCAAAATGAACGAAAAGATGAGCTTCAGATGCATCGTCTCGTACAAGCATACTG CCAACTCAAAGTGTCACCAGAAGAAGCACAACAAAGTTTTGGCAATGCAATCTCGCTCGTGAAACAAGTCTGGCC AGTCCCGCCTCGATCAGAGGTGCATAATCCATCTTTATGGGAGAGACAAAGAGCTCTTCTGCCACATGTTCAAAA GTTATGTGAGTTTTACGTGGCATCTTGCCGAAGAGACCAGCCTCTTATCCCAAAAGACGTCGTGAATTGGGACTT TCCTTCCGTGGTATACGAGGCAAGCTGGTGAGAAAAGAAACTCTTAGGCTTGAAAGTAGCAACTAATTAATTCAA CATTCAGGTTCTGCTACGAGAGTGGGATGCTAGAGTCTGTTTCAGACTTGCTGAATCCCGCGAAGGATTACTGTA TCCAACATTTGGCTTCTGGAAGGGGTTATCGCCTGTTGGCAGATATATATGGGTGCTTCGGATCTCTATGCACAG AGTCAAACCAATTTCAAGGCGCCTACGATAACTTCGCCACTGAATGGAAATATCTCGAGAAAGCTTTCGAAGCAG GGGAGCTTGAAAGACCAAGTATTTGGGAAGTCTTTGGTTTAGGGAGGCTTGGAAACGGGCACCATGGGCTGCATC AATATGCAGAAGCAGAAGCATACTATCGAAAGGCATTGGCCGCCTGGGAAAATCTTCCAGGTGATAAGAAGCTCT GGCACAGTCATCTTGCAACGTGTTTGTGGTTACAAGGTCGCCCAGATGAAGGAGAGGTAGTCGTGCGAGGAGTCA TCAAAGACGAAAATGACACAACCAATTTCAGGTAGGACCTAGAGTTCACCCCTGGAGACCATCGGTATTCAGTGC TAATGCATGAAGCCTTTAGAACTGCAATGGCAATGTATGCACTAGGCAATATTCAAATTGCCCAAGCTACAGGTT TGACACTCGAAGGAAAGAAAAAGGACGCCGAAGATAAGCTAGCTGAGGCAATGAATACCCATGTCAAAGTACTCA ATTTGTGGACGAAGACATTGGGACCAAGACACCACAAGACCTCGGATGCAATGTACAAGGTCGGCTGGCATTTGC ACAGACGCCAGGAATATGCCCAGGCATTGTCAGTCTCTATCGTTATTTCTCGCCTCGATGGCCTTTCTGCGTGCA GTACTGACTAATTGAATTAGGGACATGTTCGAGAGAGCGTTGGATATCTATGAAAGTCAGCCGCATCTATACAAA AACGAAATTGCCCGAACGAAATACAAGATAGGCTGCCTGAAGCAGGATACACAGCATCATAGTGACGGTGCAGCT TTGATCCGCGAAGCGGACCGAATCAGACAGCAGATAGTGCCGCCAGAAGACTGGGAGCCTGCGAAGTGCGAGGAG GACTTTGACAATATAGTCCAGTTCTGGACACGATAA