Fungal Genomics

Agaricus bisporus var bisporus H39 Agaricus bisporus var bisporus H97 Agaricus bisporus var burnettii H119p4 Ophiocordyceps australis 1348a (Ghana) Ophiocordyceps australis map64 (Brazil) Ophiocordyceps camponoti-floridani Ophiocordyceps camponoti-rufipedis Ophiocordyceps kimflemingae Ophiocordyceps subramaniannii Penicillium roqueforti DTO002I6 Penicillium roqueforti DTO003C3 Penicillium roqueforti DTO003H1 (CBS 147308) Penicillium roqueforti DTO006G1 Penicillium roqueforti DTO006G7 Penicillium roqueforti DTO012A1 Penicillium roqueforti DTO012A2 (CBS 147309) Penicillium roqueforti DTO012A6 (CBS 147310) Penicillium roqueforti DTO012A7 Penicillium roqueforti DTO012A8 Penicillium roqueforti DTO012A9 Penicillium roqueforti DTO013E5 Penicillium roqueforti DTO013F2 Penicillium roqueforti DTO013F5 (CBS 147311) Penicillium roqueforti DTO027I6 Penicillium roqueforti DTO032C6 Penicillium roqueforti DTO039G3 Penicillium roqueforti DTO046C5 Penicillium roqueforti DTO070G2 (CBS 147317) Penicillium roqueforti DTO081F9 (CBS 147318) Penicillium roqueforti DTO101D6 (CBS 147325) Penicillium roqueforti DTO102I9 (CBS 147326) Penicillium roqueforti DTO126G2 (CBS 147330) Penicillium roqueforti DTO127F7 (CBS 147331) Penicillium roqueforti DTO127F9 (CBS 147332) Penicillium roqueforti DTO130C1 (CBS 147333) Penicillium roqueforti DTO163C3 (CBS 147337) Penicillium roqueforti DTO163F5 (CBS 147338) Penicillium roqueforti DTO163G4 (CBS 147339) Penicillium roqueforti DTO265D5 (CBS 147372) Penicillium roqueforti DTO369A1 (CBS 147354) Penicillium roqueforti DTO375B1 (CBS 147355) Penicillium roqueforti DTO377G2 (LCP 96.3914a) Penicillium roqueforti LCP96 04111 Rhodonia placenta FPRL280

General Properties

Protein ID	Pro_DTO377G3_2|g2001.t1
Gene name
Location	scaffold_02:1387643..1390933
Strand	-
Gene length (bp)	3290
Transcript length (bp)	3240
Coding sequence length (bp)	3240
Protein length (aa)	1080

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PFAM Domains

PFAM Domain ID	Short name	Long name	E-value	Start	End
PF09416	UPF1_Zn_bind	RNA helicase (UPF2 interacting domain)	2.6E-71	69	220
PF13087	AAA_12	AAA domain	1.1E-59	633	829
PF13086	AAA_11	AAA domain	2.1E-21	424	522
PF13086	AAA_11	AAA domain	1.8E-30	526	626
PF18141	DUF5599	Domain of unknown function (DUF5599)	2.6E-32	273	367
PF13604	AAA_30	AAA domain	1.6E-12	424	622
PF13245	AAA_19	AAA domain	2.1E-10	428	621
PF04851	ResIII	Type III restriction enzyme, res subunit	9.5E-06	429	552

GO

GO Term	Description	Terminal node
GO:0005524	ATP binding	Yes
GO:0004386	helicase activity	Yes
GO:0016787	hydrolase activity	Yes
GO:0005737	cytoplasm	Yes
GO:0003677	DNA binding	Yes
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	Yes
GO:0008270	zinc ion binding	Yes
GO:1901360	organic cyclic compound metabolic process	No
GO:0010605	negative regulation of macromolecule metabolic process	No
GO:0044260	cellular macromolecule metabolic process	No
GO:0009057	macromolecule catabolic process	No
GO:0044238	primary metabolic process	No
GO:0034641	cellular nitrogen compound metabolic process	No
GO:0003824	catalytic activity	No
GO:0019439	aromatic compound catabolic process	No
GO:0009056	catabolic process	No
GO:0034655	nucleobase-containing compound catabolic process	No
GO:0046872	metal ion binding	No
GO:0032559	adenyl ribonucleotide binding	No
GO:0043168	anion binding	No
GO:0006402	mRNA catabolic process	No
GO:0097159	organic cyclic compound binding	No
GO:0046914	transition metal ion binding	No
GO:0044464	cell part	No
GO:0050789	regulation of biological process	No
GO:0046483	heterocycle metabolic process	No
GO:1901361	organic cyclic compound catabolic process	No
GO:0065007	biological regulation	No
GO:0090304	nucleic acid metabolic process	No
GO:1901363	heterocyclic compound binding	No
GO:0032555	purine ribonucleotide binding	No
GO:0044265	cellular macromolecule catabolic process	No
GO:0044248	cellular catabolic process	No
GO:0009892	negative regulation of metabolic process	No
GO:0000956	nuclear-transcribed mRNA catabolic process	No
GO:1901575	organic substance catabolic process	No
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	No
GO:0016462	pyrophosphatase activity	No
GO:0071704	organic substance metabolic process	No
GO:0032553	ribonucleotide binding	No
GO:0016071	mRNA metabolic process	No
GO:0005488	binding	No
GO:0000166	nucleotide binding	No
GO:0006807	nitrogen compound metabolic process	No
GO:0043167	ion binding	No
GO:0035639	purine ribonucleoside triphosphate binding	No
GO:0003676	nucleic acid binding	No
GO:0006725	cellular aromatic compound metabolic process	No
GO:0044424	intracellular part	No
GO:0019222	regulation of metabolic process	No
GO:0003674	molecular_function	No
GO:0016070	RNA metabolic process	No
GO:0043169	cation binding	No
GO:0016817	hydrolase activity, acting on acid anhydrides	No
GO:0044237	cellular metabolic process	No
GO:0010468	regulation of gene expression	No
GO:0036094	small molecule binding	No
GO:0048519	negative regulation of biological process	No
GO:0030554	adenyl nucleotide binding	No
GO:0044270	cellular nitrogen compound catabolic process	No
GO:0009987	cellular process	No
GO:0006139	nucleobase-containing compound metabolic process	No
GO:0006401	RNA catabolic process	No
GO:0017111	nucleoside-triphosphatase activity	No
GO:1901265	nucleoside phosphate binding	No
GO:0017076	purine nucleotide binding	No
GO:0097367	carbohydrate derivative binding	No
GO:0043170	macromolecule metabolic process	No
GO:0005575	cellular_component	No
GO:0008152	metabolic process	No
GO:0060255	regulation of macromolecule metabolic process	No
GO:0008150	biological_process	No
GO:0010629	negative regulation of gene expression	No
GO:0046700	heterocycle catabolic process	No
GO:0008144	drug binding	No

SignalP

[Help with interpreting these statistics]

SignalP signal predicted	Location (based on Ymax)	D score (significance: > 0.45)
No	1 - 50	0.45

Transmembrane Domains

(None)

Transcription Factor Class

(None)

Expression data

Analysis 1: Genome-wide gene expression in conidia of Penicillium roqueforti during growth at various temperatures and for various amounts of time. Published in Punt et al., 2020.

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Sequences

Type of sequence	Sequence
Locus	Download genbank file of locus The gene with 5 kb flanks (if sufficient flanking sequence is available). For use in cloning design programs. NOTE: features (genes or exons) that are only partially contained within the sequence are completely excluded.
Protein	>Pro_DTO377G3_2|g2001.t1 MSYQPEDPSAGVDVNEIALGRARPRRHDDEDEGSETFEDDDMESTVGVPANGNQKSQGNGEEEIELPAHACAYCG IHNASSVVKCLACNKWFCSARGNTSSSHIVNHLVRARHKEVQLHPGSSLGDTILECYNCGTKNVFLLGFIPAKSD TVVVLLCRQPCASMPSSKDMNWDTSRWQPLIEDRSFLPWLVGAPTDQEQLRARHLSPQLIAKLEEMWKDNSQATL EDLEKATAVDDEPAPVLLRYDDAFQYQNIFGPLVKIEADYDRKLKESQSQDGLIVRWDLGLNNKHLASFVLPKLE LGDVKLAVGDEMRIKYNGELRPKWEGVGYVIKIPNNQSDEVTIELRAKGDHKSVPTECTHNFMADYVWKSTSFDR MQCAMKTFAVDEQSVSGYIFHRLLGHEVAAAPMKTQIPKKFSVPGLPDLNGSQINAVKSVLQRPLSLIQGPPGTG KTVTSATIIYHLAKINGGQVLVCAPSNVAVDQLCERIHRTGLKTVRVTAKSREDVESAVGFLSLHEQVRMNDSNI ELVKLNQLKAELGELSSQDEKRLKQLTRSAEREILTNADVICCTCVGAGDPRLSKGKFRTVLIDESTQSAEPECM IPLVLGCKQVVLVGDHQQLGPVIMNKKAAKAGLNQSLFERLVILGCSPIRLNVQYRMHPCLSEFPSNMFYEGSLQ NGITIADRVRRDVDFPWPIIDDPMMFWSNLGNEEISASGTSYLNRTEATNVEKIVTRFFKAGVQPRDIGIITPYE GQRSYIVSSMQANGTFKKEHYKEIEVASVDAFQGREKDYIILSCVRSNDHQGIGFLSDPRRLNVALTRARFGLVI LGNPKVLSKHPLWNCLLQHFKERHCLVEGPLSNLQESLIQFSRPKQAYRGPQRFQMSFSQTNNGPNNAVNGRNGG HRNEYHDSGSVVGYIPDDVSSVHGSALGGVGLPSGYPPMFQNFGESWPAISGGRRANGGRPKGAPSVAGESVAAT ESDVTSSVTDGRSVDQGGVSLTGLSINEMGKQPSLSQSDRLKRYVESGGREPYRAGVPDNGSIFGGSSASIRVTR GVPGQNTHDDDDARSVSTAFASQVGGNYD*
Coding	>Pro_DTO377G3_2|g2001.t1 ATGAGCTACCAACCGGAGGACCCCTCGGCGGGAGTTGACGTTAATGAGATTGCACTTGGGCGCGCACGTCCACGC CGACATGATGACGAAGATGAAGGCTCTGAAACCTTTGAAGATGACGACATGGAAAGCACAGTCGGTGTACCCGCA AATGGGAATCAGAAGTCCCAAGGAAATGGAGAGGAGGAAATAGAGCTCCCTGCTCATGCATGCGCATACTGCGGC ATCCACAACGCGAGCAGCGTCGTCAAATGTCTTGCTTGCAATAAGTGGTTCTGCAGTGCACGTGGCAATACTTCT TCGTCCCATATCGTCAATCACCTTGTCCGAGCTCGTCATAAGGAAGTCCAACTCCACCCGGGCTCTTCTTTAGGA GATACTATTCTGGAATGCTACAACTGTGGCACCAAAAATGTATTTTTGCTTGGCTTCATCCCCGCAAAATCCGAT ACTGTTGTTGTCCTGCTTTGTCGGCAGCCATGTGCCTCTATGCCATCCTCCAAGGACATGAATTGGGACACTTCA CGATGGCAGCCTCTTATTGAGGATCGTTCTTTCCTCCCCTGGCTCGTAGGAGCACCTACTGACCAAGAACAACTC CGAGCTCGTCACCTCAGTCCTCAATTGATTGCGAAGCTGGAGGAAATGTGGAAAGACAACTCTCAGGCGACTCTG GAAGACCTAGAGAAGGCCACCGCAGTGGATGATGAGCCTGCGCCAGTCCTACTTCGCTACGACGATGCTTTCCAA TACCAAAATATTTTCGGCCCACTTGTTAAGATCGAGGCTGATTACGACCGCAAGTTGAAGGAATCTCAATCCCAA GATGGATTGATCGTGCGCTGGGATCTTGGTCTCAACAACAAGCATCTAGCAAGCTTTGTGCTGCCTAAGCTTGAG CTAGGAGATGTCAAATTGGCAGTGGGTGACGAGATGCGCATCAAGTACAATGGTGAATTGCGTCCTAAGTGGGAG GGTGTCGGGTATGTCATCAAGATTCCGAACAATCAATCTGATGAGGTCACTATCGAACTTCGCGCCAAGGGCGAC CACAAGTCAGTTCCCACCGAATGCACGCACAATTTTATGGCCGACTATGTCTGGAAGTCGACTTCCTTCGACCGC ATGCAATGTGCTATGAAGACCTTTGCCGTAGATGAGCAGAGTGTCTCAGGATACATTTTCCATCGTCTCCTTGGC CATGAGGTTGCTGCAGCTCCTATGAAGACCCAGATTCCAAAGAAATTTAGTGTTCCAGGTCTACCAGATCTGAAT GGCAGTCAAATTAACGCAGTTAAAAGTGTCCTCCAACGACCTCTCAGTTTGATCCAAGGTCCTCCCGGAACCGGT AAGACTGTTACATCGGCCACTATTATCTATCATCTTGCCAAGATCAACGGAGGTCAAGTTCTTGTCTGCGCTCCA TCCAACGTCGCCGTTGATCAGCTCTGCGAACGTATTCACCGGACGGGTCTCAAGACCGTGCGAGTTACTGCTAAA TCTCGCGAAGATGTGGAATCTGCCGTTGGTTTCCTTTCGCTGCACGAGCAGGTTCGCATGAACGATAGCAACATT GAGCTGGTAAAACTCAACCAGCTCAAGGCAGAACTTGGGGAATTGTCCAGCCAAGACGAAAAGCGCCTGAAGCAA CTTACTCGCTCTGCTGAGCGTGAAATTCTCACTAACGCAGATGTGATCTGCTGTACTTGTGTTGGTGCAGGTGAT CCTCGTCTTTCAAAGGGCAAGTTCCGCACTGTCCTGATTGACGAATCAACCCAATCTGCTGAGCCCGAGTGTATG ATTCCTCTAGTTCTGGGCTGCAAACAAGTGGTCTTGGTAGGTGATCACCAGCAACTTGGCCCTGTGATCATGAAC AAGAAGGCCGCCAAGGCCGGTCTGAACCAGTCTTTGTTCGAGCGTCTCGTGATTTTGGGCTGCTCTCCTATCCGA TTGAATGTCCAGTATCGTATGCACCCGTGCCTTTCCGAATTCCCATCCAATATGTTCTATGAAGGCTCGCTGCAG AACGGTATCACCATTGCAGATCGTGTCCGCCGTGACGTTGACTTCCCTTGGCCCATCATTGATGATCCGATGATG TTTTGGTCAAACCTGGGCAACGAAGAAATCTCCGCGTCTGGCACCTCGTATCTTAACCGTACTGAAGCTACCAAC GTCGAGAAGATTGTCACTCGCTTCTTCAAGGCAGGTGTTCAGCCTAGGGATATTGGTATCATCACTCCATACGAG GGACAGCGGAGCTACATCGTCAGCTCTATGCAGGCAAACGGTACCTTCAAGAAAGAACATTACAAGGAGATCGAG GTTGCGTCGGTCGACGCATTCCAAGGCAGAGAGAAGGATTATATTATCCTTTCTTGTGTTCGTTCTAATGATCAC CAAGGTATTGGTTTCCTGAGCGATCCCCGTCGTCTCAACGTGGCCCTTACTCGTGCTCGATTTGGCCTGGTCATC CTCGGAAACCCCAAGGTCTTGTCTAAGCACCCATTGTGGAATTGCCTTTTGCAGCACTTCAAGGAACGCCACTGT CTTGTGGAGGGGCCGCTTTCCAACCTTCAGGAGTCCTTGATTCAATTCAGCCGGCCCAAGCAAGCATACAGAGGC CCGCAGCGGTTCCAGATGTCTTTCAGTCAGACAAATAATGGCCCAAATAATGCAGTGAATGGTCGCAACGGTGGT CACCGCAACGAGTATCATGACTCGGGGTCTGTGGTGGGCTATATCCCTGACGATGTATCTTCTGTTCATGGCTCG GCACTTGGTGGTGTTGGCCTTCCATCTGGCTACCCCCCTATGTTCCAGAATTTTGGCGAGTCCTGGCCTGCGATC TCTGGCGGTCGTCGAGCGAACGGTGGCCGACCCAAGGGAGCCCCCAGTGTGGCTGGCGAGTCAGTCGCTGCCACT GAGTCCGATGTCACATCCAGCGTCACTGACGGACGGAGCGTTGATCAAGGCGGTGTCAGTCTCACTGGCCTGAGC ATTAATGAAATGGGCAAGCAGCCCAGTCTCAGTCAATCTGACCGTTTGAAGCGCTATGTCGAGTCTGGAGGACGC GAGCCTTACAGGGCTGGAGTTCCGGACAACGGCAGCATCTTCGGAGGCAGCTCCGCTAGCATTCGAGTGACTCGC GGCGTGCCGGGCCAAAACACGCACGACGACGATGATGCCCGTAGCGTCTCTACTGCTTTCGCTAGCCAAGTTGGT GGCAACTATGACTGA
Transcript	>Pro_DTO377G3_2|g2001.t1 ATGAGCTACCAACCGGAGGACCCCTCGGCGGGAGTTGACGTTAATGAGATTGCACTTGGGCGCGCACGTCCACGC CGACATGATGACGAAGATGAAGGCTCTGAAACCTTTGAAGATGACGACATGGAAAGCACAGTCGGTGTACCCGCA AATGGGAATCAGAAGTCCCAAGGAAATGGAGAGGAGGAAATAGAGCTCCCTGCTCATGCATGCGCATACTGCGGC ATCCACAACGCGAGCAGCGTCGTCAAATGTCTTGCTTGCAATAAGTGGTTCTGCAGTGCACGTGGCAATACTTCT TCGTCCCATATCGTCAATCACCTTGTCCGAGCTCGTCATAAGGAAGTCCAACTCCACCCGGGCTCTTCTTTAGGA GATACTATTCTGGAATGCTACAACTGTGGCACCAAAAATGTATTTTTGCTTGGCTTCATCCCCGCAAAATCCGAT ACTGTTGTTGTCCTGCTTTGTCGGCAGCCATGTGCCTCTATGCCATCCTCCAAGGACATGAATTGGGACACTTCA CGATGGCAGCCTCTTATTGAGGATCGTTCTTTCCTCCCCTGGCTCGTAGGAGCACCTACTGACCAAGAACAACTC CGAGCTCGTCACCTCAGTCCTCAATTGATTGCGAAGCTGGAGGAAATGTGGAAAGACAACTCTCAGGCGACTCTG GAAGACCTAGAGAAGGCCACCGCAGTGGATGATGAGCCTGCGCCAGTCCTACTTCGCTACGACGATGCTTTCCAA TACCAAAATATTTTCGGCCCACTTGTTAAGATCGAGGCTGATTACGACCGCAAGTTGAAGGAATCTCAATCCCAA GATGGATTGATCGTGCGCTGGGATCTTGGTCTCAACAACAAGCATCTAGCAAGCTTTGTGCTGCCTAAGCTTGAG CTAGGAGATGTCAAATTGGCAGTGGGTGACGAGATGCGCATCAAGTACAATGGTGAATTGCGTCCTAAGTGGGAG GGTGTCGGGTATGTCATCAAGATTCCGAACAATCAATCTGATGAGGTCACTATCGAACTTCGCGCCAAGGGCGAC CACAAGTCAGTTCCCACCGAATGCACGCACAATTTTATGGCCGACTATGTCTGGAAGTCGACTTCCTTCGACCGC ATGCAATGTGCTATGAAGACCTTTGCCGTAGATGAGCAGAGTGTCTCAGGATACATTTTCCATCGTCTCCTTGGC CATGAGGTTGCTGCAGCTCCTATGAAGACCCAGATTCCAAAGAAATTTAGTGTTCCAGGTCTACCAGATCTGAAT GGCAGTCAAATTAACGCAGTTAAAAGTGTCCTCCAACGACCTCTCAGTTTGATCCAAGGTCCTCCCGGAACCGGT AAGACTGTTACATCGGCCACTATTATCTATCATCTTGCCAAGATCAACGGAGGTCAAGTTCTTGTCTGCGCTCCA TCCAACGTCGCCGTTGATCAGCTCTGCGAACGTATTCACCGGACGGGTCTCAAGACCGTGCGAGTTACTGCTAAA TCTCGCGAAGATGTGGAATCTGCCGTTGGTTTCCTTTCGCTGCACGAGCAGGTTCGCATGAACGATAGCAACATT GAGCTGGTAAAACTCAACCAGCTCAAGGCAGAACTTGGGGAATTGTCCAGCCAAGACGAAAAGCGCCTGAAGCAA CTTACTCGCTCTGCTGAGCGTGAAATTCTCACTAACGCAGATGTGATCTGCTGTACTTGTGTTGGTGCAGGTGAT CCTCGTCTTTCAAAGGGCAAGTTCCGCACTGTCCTGATTGACGAATCAACCCAATCTGCTGAGCCCGAGTGTATG ATTCCTCTAGTTCTGGGCTGCAAACAAGTGGTCTTGGTAGGTGATCACCAGCAACTTGGCCCTGTGATCATGAAC AAGAAGGCCGCCAAGGCCGGTCTGAACCAGTCTTTGTTCGAGCGTCTCGTGATTTTGGGCTGCTCTCCTATCCGA TTGAATGTCCAGTATCGTATGCACCCGTGCCTTTCCGAATTCCCATCCAATATGTTCTATGAAGGCTCGCTGCAG AACGGTATCACCATTGCAGATCGTGTCCGCCGTGACGTTGACTTCCCTTGGCCCATCATTGATGATCCGATGATG TTTTGGTCAAACCTGGGCAACGAAGAAATCTCCGCGTCTGGCACCTCGTATCTTAACCGTACTGAAGCTACCAAC GTCGAGAAGATTGTCACTCGCTTCTTCAAGGCAGGTGTTCAGCCTAGGGATATTGGTATCATCACTCCATACGAG GGACAGCGGAGCTACATCGTCAGCTCTATGCAGGCAAACGGTACCTTCAAGAAAGAACATTACAAGGAGATCGAG GTTGCGTCGGTCGACGCATTCCAAGGCAGAGAGAAGGATTATATTATCCTTTCTTGTGTTCGTTCTAATGATCAC CAAGGTATTGGTTTCCTGAGCGATCCCCGTCGTCTCAACGTGGCCCTTACTCGTGCTCGATTTGGCCTGGTCATC CTCGGAAACCCCAAGGTCTTGTCTAAGCACCCATTGTGGAATTGCCTTTTGCAGCACTTCAAGGAACGCCACTGT CTTGTGGAGGGGCCGCTTTCCAACCTTCAGGAGTCCTTGATTCAATTCAGCCGGCCCAAGCAAGCATACAGAGGC CCGCAGCGGTTCCAGATGTCTTTCAGTCAGACAAATAATGGCCCAAATAATGCAGTGAATGGTCGCAACGGTGGT CACCGCAACGAGTATCATGACTCGGGGTCTGTGGTGGGCTATATCCCTGACGATGTATCTTCTGTTCATGGCTCG GCACTTGGTGGTGTTGGCCTTCCATCTGGCTACCCCCCTATGTTCCAGAATTTTGGCGAGTCCTGGCCTGCGATC TCTGGCGGTCGTCGAGCGAACGGTGGCCGACCCAAGGGAGCCCCCAGTGTGGCTGGCGAGTCAGTCGCTGCCACT GAGTCCGATGTCACATCCAGCGTCACTGACGGACGGAGCGTTGATCAAGGCGGTGTCAGTCTCACTGGCCTGAGC ATTAATGAAATGGGCAAGCAGCCCAGTCTCAGTCAATCTGACCGTTTGAAGCGCTATGTCGAGTCTGGAGGACGC GAGCCTTACAGGGCTGGAGTTCCGGACAACGGCAGCATCTTCGGAGGCAGCTCCGCTAGCATTCGAGTGACTCGC GGCGTGCCGGGCCAAAACACGCACGACGACGATGATGCCCGTAGCGTCTCTACTGCTTTCGCTAGCCAAGTTGGT GGCAACTATGACTGA
Gene	>Pro_DTO377G3_2|g2001.t1 ATGAGCTACCAACCGGAGGACCCCTCGGCGGGAGTTGACGTTAATGAGATTGCACTTGGGCGCGCACGTCCACGC CGACATGATGACGAAGATGAAGGCTCTGAAACCTTTGAAGATGACGACATGGAAAGCACAGTCGGTGTACCCGCA AATGGGAATCAGAAGTCCCAAGGAAATGGAGAGGAGGAAATAGAGCTCCCTGCTCATGCATGCGCGTCAGTGTTT ATATTCCCTTAGTGGATCGCATTTACTGATTATGTTATAGATACTGCGGCATCCACAACGCGAGCAGCGTCGTCA AATGTCTTGCTTGCAATAAGTGGTTCTGCAGTGCACGTGGCAATACTTCTTCGTCCCATATCGTCAATCACCTTG TCCGAGCTCGTCATAAGGAAGTCCAACTCCACCCGGGCTCTTCTTTAGGAGATACTATTCTGGAATGCTACAACT GTGGCACCAAAAATGTATTTTTGCTTGGCTTCATCCCCGCAAAATCCGATACTGTTGTTGTCCTGCTTTGTCGGC AGCCATGTGCCTCTATGCCATCCTCCAAGGACATGAATTGGGACACTTCACGATGGCAGCCTCTTATTGAGGATC GTTCTTTCCTCCCCTGGCTCGTAGGAGCACCTACTGACCAAGAACAACTCCGAGCTCGTCACCTCAGTCCTCAAT TGATTGCGAAGCTGGAGGAAATGTGGAAAGACAACTCTCAGGCGACTCTGGAAGACCTAGAGAAGGCCACCGCAG TGGATGATGAGCCTGCGCCAGTCCTACTTCGCTACGACGATGCTTTCCAATACCAAAATATTTTCGGCCCACTTG TTAAGATCGAGGCTGATTACGACCGCAAGTTGAAGGAATCTCAATCCCAAGATGGATTGATCGTGCGCTGGGATC TTGGTCTCAACAACAAGCATCTAGCAAGCTTTGTGCTGCCTAAGCTTGAGCTAGGAGATGTCAAATTGGCAGTGG GTGACGAGATGCGCATCAAGTACAATGGTGAATTGCGTCCTAAGTGGGAGGGTGTCGGGTATGTCATCAAGATTC CGAACAATCAATCTGATGAGGTCACTATCGAACTTCGCGCCAAGGGCGACCACAAGTCAGTTCCCACCGAATGCA CGCACAATTTTATGGCCGACTATGTCTGGAAGTCGACTTCCTTCGACCGCATGCAATGTGCTATGAAGACCTTTG CCGTAGATGAGCAGAGTGTCTCAGGATACATTTTCCATCGTCTCCTTGGCCATGAGGTTGCTGCAGCTCCTATGA AGACCCAGATTCCAAAGAAATTTAGTGTTCCAGGTCTACCAGATCTGAATGGCAGTCAAATTAACGCAGTTAAAA GTGTCCTCCAACGACCTCTCAGTTTGATCCAAGGTCCTCCCGGAACCGGTAAGACTGTTACATCGGCCACTATTA TCTATCATCTTGCCAAGATCAACGGAGGTCAAGTTCTTGTCTGCGCTCCATCCAACGTCGCCGTTGATCAGCTCT GCGAACGTATTCACCGGACGGGTCTCAAGACCGTGCGAGTTACTGCTAAATCTCGCGAAGATGTGGAATCTGCCG TTGGTTTCCTTTCGCTGCACGAGCAGGTTCGCATGAACGATAGCAACATTGAGCTGGTAAAACTCAACCAGCTCA AGGCAGAACTTGGGGAATTGTCCAGCCAAGACGAAAAGCGCCTGAAGCAACTTACTCGCTCTGCTGAGCGTGAAA TTCTCACTAACGCAGATGTGATCTGCTGTACTTGTGTTGGTGCAGGTGATCCTCGTCTTTCAAAGGGCAAGTTCC GCACTGTCCTGATTGACGAATCAACCCAATCTGCTGAGCCCGAGTGTATGATTCCTCTAGTTCTGGGCTGCAAAC AAGTGGTCTTGGTAGGTGATCACCAGCAACTTGGCCCTGTGATCATGAACAAGAAGGCCGCCAAGGCCGGTCTGA ACCAGTCTTTGTTCGAGCGTCTCGTGATTTTGGGCTGCTCTCCTATCCGATTGAATGTCCAGTATCGTATGCACC CGTGCCTTTCCGAATTCCCATCCAATATGTTCTATGAAGGCTCGCTGCAGAACGGTATCACCATTGCAGATCGTG TCCGCCGTGACGTTGACTTCCCTTGGCCCATCATTGATGATCCGATGATGTTTTGGTCAAACCTGGGCAACGAAG AAATCTCCGCGTCTGGCACCTCGTATCTTAACCGTACTGAAGCTACCAACGTCGAGAAGATTGTCACTCGCTTCT TCAAGGCAGGTGTTCAGCCTAGGGATATTGGTATCATCACTCCATACGAGGGACAGCGGAGCTACATCGTCAGCT CTATGCAGGCAAACGGTACCTTCAAGAAAGAACATTACAAGGAGATCGAGGTTGCGTCGGTCGACGCATTCCAAG GCAGAGAGAAGGATTATATTATCCTTTCTTGTGTTCGTTCTAATGATCACCAAGGTATTGGTTTCCTGAGCGATC CCCGTCGTCTCAACGTGGCCCTTACTCGTGCTCGATTTGGCCTGGTCATCCTCGGAAACCCCAAGGTCTTGTCTA AGCACCCATTGTGGAATTGCCTTTTGCAGCACTTCAAGGAACGCCACTGTCTTGTGGAGGGGCCGCTTTCCAACC TTCAGGAGTCCTTGATTCAATTCAGCCGGCCCAAGCAAGCATACAGAGGCCCGCAGCGGTTCCAGATGTCTTTCA GTCAGACAAATAATGGCCCAAATAATGCAGTGAATGGTCGCAACGGTGGTCACCGCAACGAGTATCATGACTCGG GGTCTGTGGTGGGCTATATCCCTGACGATGTATCTTCTGTTCATGGCTCGGCACTTGGTGGTGTTGGCCTTCCAT CTGGCTACCCCCCTATGTTCCAGAATTTTGGCGAGTCCTGGCCTGCGATCTCTGGCGGTCGTCGAGCGAACGGTG GCCGACCCAAGGGAGCCCCCAGTGTGGCTGGCGAGTCAGTCGCTGCCACTGAGTCCGATGTCACATCCAGCGTCA CTGACGGACGGAGCGTTGATCAAGGCGGTGTCAGTCTCACTGGCCTGAGCATTAATGAAATGGGCAAGCAGCCCA GTCTCAGTCAATCTGACCGTTTGAAGCGCTATGTCGAGTCTGGAGGACGCGAGCCTTACAGGGCTGGAGTTCCGG ACAACGGCAGCATCTTCGGAGGCAGCTCCGCTAGCATTCGAGTGACTCGCGGCGTGCCGGGCCAAAACACGCACG ACGACGATGATGCCCGTAGCGTCTCTACTGCTTTCGCTAGCCAAGTTGGTGGCAACTATGACTGA