Fungal Genomics

Agaricus bisporus var bisporus H39 Agaricus bisporus var bisporus H97 Agaricus bisporus var burnettii H119p4 Aspergillus niger CBS 112.32 Aspergillus niger CBS 113.50 Aspergillus niger CBS 115988 Aspergillus niger CBS 115989 Aspergillus niger CBS 118.52 Aspergillus niger CBS 124.48 Aspergillus niger CBS 131.52 Aspergillus niger CBS 133816 Aspergillus niger CBS 147320 Aspergillus niger CBS 147321 Aspergillus niger CBS 147322 Aspergillus niger CBS 147323 Aspergillus niger CBS 147324 Aspergillus niger CBS 147343 Aspergillus niger CBS 147344 Aspergillus niger CBS 147345 Aspergillus niger CBS 147346 Aspergillus niger CBS 147347 Aspergillus niger CBS 147352 Aspergillus niger CBS 147353 Aspergillus niger CBS 147371 Aspergillus niger CBS 147482 Aspergillus niger CBS 630.78 Aspergillus niger CBS 769.97 Niveomyces coronatus CBS 149186 Ophiocordyceps australis 1348a (Ghana) Ophiocordyceps australis map64 (Brazil) Ophiocordyceps camponoti-floridani Ophiocordyceps camponoti-rufipedis Ophiocordyceps kimflemingae Ophiocordyceps subramaniannii Penicillium roqueforti DTO002I6 Penicillium roqueforti DTO003C3 Penicillium roqueforti DTO003H1 (CBS 147308) Penicillium roqueforti DTO006G1 Penicillium roqueforti DTO006G7 Penicillium roqueforti DTO012A1 Penicillium roqueforti DTO012A2 (CBS 147309) Penicillium roqueforti DTO012A6 (CBS 147310) Penicillium roqueforti DTO012A7 Penicillium roqueforti DTO012A8 Penicillium roqueforti DTO012A9 Penicillium roqueforti DTO013E5 Penicillium roqueforti DTO013F2 Penicillium roqueforti DTO013F5 (CBS 147311) Penicillium roqueforti DTO027I6 Penicillium roqueforti DTO032C6 Penicillium roqueforti DTO039G3 Penicillium roqueforti DTO046C5 Penicillium roqueforti DTO070G2 (CBS 147317) Penicillium roqueforti DTO081F9 (CBS 147318) Penicillium roqueforti DTO101D6 (CBS 147325) Penicillium roqueforti DTO102I9 (CBS 147326) Penicillium roqueforti DTO126G2 (CBS 147330) Penicillium roqueforti DTO127F7 (CBS 147331) Penicillium roqueforti DTO127F9 (CBS 147332) Penicillium roqueforti DTO130C1 (CBS 147333) Penicillium roqueforti DTO163C3 (CBS 147337) Penicillium roqueforti DTO163F5 (CBS 147338) Penicillium roqueforti DTO163G4 (CBS 147339) Penicillium roqueforti DTO265D5 (CBS 147372) Penicillium roqueforti DTO369A1 (CBS 147354) Penicillium roqueforti DTO375B1 (CBS 147355) Penicillium roqueforti DTO377G2 (LCP 96.3914a) Penicillium roqueforti LCP96 04111 Rhodonia placenta FPRL280 Torrubiellomyces zombiae CBS 149187

General Properties

Protein ID	Pro_DTO377G3_2|g1800.t1
Gene name
Location	scaffold_02:867924..871995
Strand	+
Gene length (bp)	4071
Transcript length (bp)	3372
Coding sequence length (bp)	3372
Protein length (aa)	1124

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PFAM Domains

PFAM Domain ID	Short name	Long name	E-value	Start	End
PF18345	zf_CCCH_4	Zinc finger domain	5.0E-07	1102	1120
PF18044	zf-CCCH_4	CCCH-type zinc finger	4.8E-07	1102	1121
PF00642	zf-CCCH	Zinc finger C-x8-C-x5-C-x3-H type (and similar)	2.1E-04	1100	1121

GO

GO Term	Description	Terminal node
GO:0046872	metal ion binding	Yes
GO:0005488	binding	No
GO:0043167	ion binding	No
GO:0043169	cation binding	No
GO:0003674	molecular_function	No

SignalP

[Help with interpreting these statistics]

SignalP signal predicted	Location (based on Ymax)	D score (significance: > 0.45)
No	1 - 54	0.45

Transmembrane Domains

(None)

Transcription Factor Class

(None)

Expression data

Analysis 1: Genome-wide gene expression in conidia of Penicillium roqueforti during growth at various temperatures and for various amounts of time. Published in Punt et al., 2020.

Expression values

Label	Description	Expression (RPKM)	Confidence interval (low)	Confidence interval (high)
3d_25C	Three days - 25 degrees Celsius	23.71	14.31	33.10
5d_25C	Five days - 25 degrees Celsius	29.86	18.20	41.52
7d_25C	Seven days - 25 degrees Celsius	27.40	16.61	38.20
10d_25C	Ten days - 25 degrees Celsius	28.21	17.12	39.29
7d_15C	Seven days - 15 degrees Celsius	31.83	19.39	44.26
7d_30C	Seven days - 30 degrees Celsius	29.00	17.66	40.35

Differential expression

Label1	Label2	Q-value	Significant difference
3d_25C	5d_25C	0.328059	no
3d_25C	7d_25C	0.595356	no
3d_25C	7d_15C	0.194727	no
3d_25C	7d_30C	0.412849	no
3d_25C	10d_25C	0.499863	no
5d_25C	7d_25C	0.775953	no
5d_25C	7d_15C	0.837179	no
5d_25C	7d_30C	0.930134	no
5d_25C	10d_25C	0.860314	no
7d_25C	7d_15C	0.579156	no
7d_25C	7d_30C	0.858223	no
7d_25C	10d_25C	0.932450	no
7d_15C	7d_30C	0.752350	no
7d_15C	10d_25C	0.667627	no
7d_30C	10d_25C	0.936390	no

Sequences

Type of sequence	Sequence
Locus	Download genbank file of locus The gene with 5 kb flanks (if sufficient flanking sequence is available). For use in cloning design programs. NOTE: features (genes or exons) that are only partially contained within the sequence are completely excluded.
Protein	>Pro_DTO377G3_2|g1800.t1 MEQSAQTPIQGLSHGNSLPADYWSTLDPAYPDPEQQLQQPSQPQHQPQQQHDSASQPTPLGIGWDHPVFQQQPRE LASRPDPNHGIYSSVHQPWQQANPLQQPPQRGYGASHQYQIHSQAPHFQQDGLSFDSRPLSASESSSFPSFPYQQ NYFHPQNTHISVPDTFPEAPAQQRIQPRQQQQPQSSISAYSLPQSYSSEMLQNTIDLTNDYSDSDPNVTINPQFL NSIPQAFNPQQSSLTNNFIQGIPADLKQQGSEQGRQFNYYQHDLSVQSHMALNGNPVIPPGGLPVLQVVVPDKKG ASNKQQTKKTSQNGRMRTLSKSESESSDESDLEIEAPDEPSPIPPIRPTEPEAAAQYDTLQAVWSPRNKWPGPEK VKNALVAYKELVKGLRDAWKEQVQAMKLAENQDDNQKATQLKEKVTSQRRTMDKIATTTLEMGHPNIVEKYVSLS SPNPYIFPPFHLAICPSEAICESLWGESLLSRNWLKLAALLGEHPMVVAALYSFLLDRFQAADFAGTLTINLLSL FSRFSTLTEDLMQKTNLSKLLPKFLKKGGQQVKDLTQKILDNAAASTKRKHESEKSAKEDSHPRSVLADQPKGEA GVKRPREADSNLQPGTKRMAVTNPLKDVNKHAPASNGPVKGAQSSKPTGAAVLRPKANIVAPKPTSLFGTLSSAS KRPGTTNADRAAAAAAAKPTAASEKEKTPAPKPSFSFGDIMADLNKPKQAPSPKPAEDQPPETEAERKNRLRKEE RRKLRVTWKPDDALTEVRLFTHDPDEELGPGDGSLRSRGDVKGEGSVLKLHKDMDELEEEDLGETVFQDGYTLSM VDFDFEESNDGSFIKRGGTQLPTSPEREAQEHRESTTLMVFYTSPADMPDTPKEPPAPDPDDIVTDVLPFGELPD LVKVRQERYYSYMNPKPTTPQPTQQPQRPTPGDSGFDISNLLKIIQGVPGQAQPIPAPQATQPGGMPDLERTISM FRQQQPQPQVPPAPPVPIPQPQGLDFNAILNVMKQMQAPPAYSQPQQSQSAMAPNLGAMFAQFGGQNQNGALPFR QQGHDYEDPERKRGREGGYYDDNSNPESWSRSKRTKFGANEAKPYKVGLVACRFWAEGKCRKGDNCTFRHDPL*
Coding	>Pro_DTO377G3_2|g1800.t1 ATGGAGCAATCAGCTCAAACCCCTATTCAGGGGTTATCTCATGGGAATTCACTACCTGCTGATTACTGGAGCACA CTTGACCCCGCCTACCCTGATCCCGAGCAGCAGCTTCAGCAGCCATCTCAACCCCAGCACCAGCCTCAACAGCAG CACGATTCTGCATCGCAACCAACACCTCTTGGGATCGGATGGGACCATCCTGTTTTTCAACAGCAGCCAAGAGAG CTAGCCTCACGACCAGATCCGAACCATGGCATTTACTCATCAGTGCATCAGCCTTGGCAGCAAGCAAATCCTTTG CAACAGCCACCGCAACGAGGATATGGAGCTTCGCATCAGTATCAGATACATTCCCAAGCTCCTCATTTCCAACAA GATGGGTTATCTTTTGACTCTCGTCCCCTGAGCGCCTCCGAATCTTCGTCATTTCCATCATTTCCCTACCAGCAA AATTATTTCCATCCACAAAACACACACATCTCAGTGCCAGACACATTTCCTGAAGCACCCGCGCAGCAGAGAATA CAGCCACGGCAACAGCAACAACCCCAGTCGTCAATTTCTGCATACTCTTTACCTCAAAGCTACTCCTCGGAAATG CTGCAAAACACAATTGATTTGACCAACGATTACTCCGATTCAGACCCGAATGTCACCATCAACCCCCAGTTCCTA AATTCTATCCCGCAGGCATTCAATCCACAGCAGTCTTCGTTGACAAACAACTTTATTCAGGGAATTCCTGCAGAC CTCAAACAACAAGGGAGCGAACAGGGTAGGCAATTTAATTACTACCAGCATGATCTTTCAGTCCAGTCGCATATG GCACTAAATGGCAACCCGGTGATTCCACCTGGAGGATTACCAGTACTGCAAGTTGTAGTCCCCGATAAGAAGGGC GCTTCTAATAAGCAGCAAACGAAGAAGACTTCTCAAAATGGCCGAATGAGAACTTTATCTAAGTCAGAAAGTGAA AGTTCGGATGAATCCGATCTTGAGATTGAAGCACCTGACGAGCCTTCTCCTATCCCTCCGATCCGCCCGACTGAG CCCGAGGCTGCAGCGCAATATGATACCCTCCAAGCCGTGTGGTCACCGAGGAACAAATGGCCTGGTCCTGAGAAG GTCAAGAATGCGCTGGTAGCCTACAAAGAGCTTGTCAAAGGATTAAGAGATGCGTGGAAGGAACAAGTTCAGGCC ATGAAGCTGGCTGAAAACCAAGATGACAACCAGAAAGCAACACAACTTAAGGAGAAAGTCACTTCGCAACGTCGT ACCATGGATAAAATTGCGACCACGACACTGGAAATGGGTCATCCCAATATTGTTGAGAAGTATGTATCCCTCTCC TCTCCCAACCCCTATATCTTCCCTCCCTTCCATCTGGCTATATGCCCTTCAGAAGCTATCTGTGAATCTCTTTGG GGGGAATCTCTCCTATCTAGAAATTGGCTCAAACTTGCAGCTTTGCTGGGAGAGCATCCTATGGTTGTGGCGGCT TTATATTCGTTCTTACTCGATCGTTTCCAAGCAGCAGACTTTGCTGGGACTCTGACTATTAATTTGCTTTCGCTC TTCTCGCGTTTCTCGACTTTGACAGAAGACCTGATGCAAAAGACCAATCTTTCCAAATTGTTGCCAAAGTTTCTC AAAAAGGGTGGCCAGCAGGTTAAGGACCTCACACAGAAGATATTGGATAATGCTGCGGCCTCTACGAAGCGTAAA CACGAGAGTGAAAAGTCCGCCAAGGAAGACTCTCATCCAAGGAGCGTTTTAGCAGATCAGCCTAAAGGAGAGGCT GGAGTGAAGCGACCCCGTGAGGCGGATAGCAATCTGCAGCCTGGCACAAAACGAATGGCAGTTACCAATCCCTTG AAGGATGTGAATAAACATGCACCCGCAAGCAATGGACCGGTCAAAGGAGCACAAAGTAGTAAGCCAACCGGCGCT GCAGTGCTGCGCCCTAAAGCCAATATCGTGGCCCCTAAGCCAACAAGTCTCTTTGGCACTTTAAGTTCGGCGTCC AAGAGACCCGGGACCACAAATGCGGATAGGGCTGCTGCCGCCGCCGCAGCAAAGCCAACTGCTGCTTCCGAAAAG GAAAAGACACCAGCCCCAAAGCCATCTTTCTCATTTGGCGACATTATGGCCGACTTGAACAAACCCAAGCAGGCA CCAAGCCCCAAGCCCGCCGAAGATCAGCCCCCGGAGACTGAAGCTGAGCGCAAAAACAGGTTGCGTAAAGAAGAG CGCCGTAAACTTCGCGTGACCTGGAAGCCGGATGATGCTCTTACCGAAGTCCGACTATTTACCCACGACCCGGAT GAAGAATTAGGTCCCGGCGATGGGTCATTGCGCTCACGAGGAGACGTTAAAGGTGAAGGTAGTGTTCTCAAGCTT CACAAAGATATGGACGAATTGGAAGAAGAGGATCTCGGTGAGACCGTATTTCAAGACGGTTATACTCTTTCAATG GTCGATTTCGATTTCGAGGAATCAAATGATGGCAGTTTCATCAAGCGCGGCGGCACTCAGCTGCCCACGAGTCCC GAGAGGGAGGCTCAGGAGCATCGGGAATCTACTACCCTTATGGTCTTCTATACCTCTCCTGCTGACATGCCCGAC ACACCAAAGGAACCACCAGCTCCTGACCCCGACGATATTGTTACCGATGTATTGCCTTTCGGAGAGTTGCCCGAC CTGGTCAAGGTCCGCCAGGAACGTTACTACTCCTACATGAATCCCAAGCCTACGACTCCCCAACCAACCCAACAA CCGCAGCGACCTACTCCCGGAGACAGTGGATTTGACATCTCCAATTTGCTCAAGATCATCCAGGGTGTTCCTGGA CAGGCGCAACCAATCCCAGCCCCGCAGGCAACTCAACCCGGGGGCATGCCGGATCTCGAGAGGACCATCAGCATG TTCCGTCAACAACAACCTCAACCACAGGTCCCCCCGGCTCCACCAGTACCAATTCCACAGCCGCAAGGCCTTGAC TTCAACGCGATATTGAATGTTATGAAACAAATGCAGGCGCCGCCTGCATATTCCCAGCCCCAGCAATCGCAATCA GCAATGGCACCTAACCTGGGCGCCATGTTCGCACAATTCGGTGGGCAGAACCAAAACGGTGCTCTCCCATTCCGA CAGCAAGGGCATGACTATGAAGACCCAGAGCGCAAGCGCGGCCGCGAGGGCGGTTATTATGACGACAATTCTAAC CCCGAATCGTGGAGCCGCTCGAAACGAACCAAATTTGGCGCCAACGAGGCCAAGCCTTATAAGGTGGGACTAGTT GCTTGCAGATTTTGGGCCGAGGGCAAGTGTCGCAAAGGCGACAACTGCACTTTCCGCCACGATCCTCTCTAA
Transcript	>Pro_DTO377G3_2|g1800.t1 ATGGAGCAATCAGCTCAAACCCCTATTCAGGGGTTATCTCATGGGAATTCACTACCTGCTGATTACTGGAGCACA CTTGACCCCGCCTACCCTGATCCCGAGCAGCAGCTTCAGCAGCCATCTCAACCCCAGCACCAGCCTCAACAGCAG CACGATTCTGCATCGCAACCAACACCTCTTGGGATCGGATGGGACCATCCTGTTTTTCAACAGCAGCCAAGAGAG CTAGCCTCACGACCAGATCCGAACCATGGCATTTACTCATCAGTGCATCAGCCTTGGCAGCAAGCAAATCCTTTG CAACAGCCACCGCAACGAGGATATGGAGCTTCGCATCAGTATCAGATACATTCCCAAGCTCCTCATTTCCAACAA GATGGGTTATCTTTTGACTCTCGTCCCCTGAGCGCCTCCGAATCTTCGTCATTTCCATCATTTCCCTACCAGCAA AATTATTTCCATCCACAAAACACACACATCTCAGTGCCAGACACATTTCCTGAAGCACCCGCGCAGCAGAGAATA CAGCCACGGCAACAGCAACAACCCCAGTCGTCAATTTCTGCATACTCTTTACCTCAAAGCTACTCCTCGGAAATG CTGCAAAACACAATTGATTTGACCAACGATTACTCCGATTCAGACCCGAATGTCACCATCAACCCCCAGTTCCTA AATTCTATCCCGCAGGCATTCAATCCACAGCAGTCTTCGTTGACAAACAACTTTATTCAGGGAATTCCTGCAGAC CTCAAACAACAAGGGAGCGAACAGGGTAGGCAATTTAATTACTACCAGCATGATCTTTCAGTCCAGTCGCATATG GCACTAAATGGCAACCCGGTGATTCCACCTGGAGGATTACCAGTACTGCAAGTTGTAGTCCCCGATAAGAAGGGC GCTTCTAATAAGCAGCAAACGAAGAAGACTTCTCAAAATGGCCGAATGAGAACTTTATCTAAGTCAGAAAGTGAA AGTTCGGATGAATCCGATCTTGAGATTGAAGCACCTGACGAGCCTTCTCCTATCCCTCCGATCCGCCCGACTGAG CCCGAGGCTGCAGCGCAATATGATACCCTCCAAGCCGTGTGGTCACCGAGGAACAAATGGCCTGGTCCTGAGAAG GTCAAGAATGCGCTGGTAGCCTACAAAGAGCTTGTCAAAGGATTAAGAGATGCGTGGAAGGAACAAGTTCAGGCC ATGAAGCTGGCTGAAAACCAAGATGACAACCAGAAAGCAACACAACTTAAGGAGAAAGTCACTTCGCAACGTCGT ACCATGGATAAAATTGCGACCACGACACTGGAAATGGGTCATCCCAATATTGTTGAGAAGTATGTATCCCTCTCC TCTCCCAACCCCTATATCTTCCCTCCCTTCCATCTGGCTATATGCCCTTCAGAAGCTATCTGTGAATCTCTTTGG GGGGAATCTCTCCTATCTAGAAATTGGCTCAAACTTGCAGCTTTGCTGGGAGAGCATCCTATGGTTGTGGCGGCT TTATATTCGTTCTTACTCGATCGTTTCCAAGCAGCAGACTTTGCTGGGACTCTGACTATTAATTTGCTTTCGCTC TTCTCGCGTTTCTCGACTTTGACAGAAGACCTGATGCAAAAGACCAATCTTTCCAAATTGTTGCCAAAGTTTCTC AAAAAGGGTGGCCAGCAGGTTAAGGACCTCACACAGAAGATATTGGATAATGCTGCGGCCTCTACGAAGCGTAAA CACGAGAGTGAAAAGTCCGCCAAGGAAGACTCTCATCCAAGGAGCGTTTTAGCAGATCAGCCTAAAGGAGAGGCT GGAGTGAAGCGACCCCGTGAGGCGGATAGCAATCTGCAGCCTGGCACAAAACGAATGGCAGTTACCAATCCCTTG AAGGATGTGAATAAACATGCACCCGCAAGCAATGGACCGGTCAAAGGAGCACAAAGTAGTAAGCCAACCGGCGCT GCAGTGCTGCGCCCTAAAGCCAATATCGTGGCCCCTAAGCCAACAAGTCTCTTTGGCACTTTAAGTTCGGCGTCC AAGAGACCCGGGACCACAAATGCGGATAGGGCTGCTGCCGCCGCCGCAGCAAAGCCAACTGCTGCTTCCGAAAAG GAAAAGACACCAGCCCCAAAGCCATCTTTCTCATTTGGCGACATTATGGCCGACTTGAACAAACCCAAGCAGGCA CCAAGCCCCAAGCCCGCCGAAGATCAGCCCCCGGAGACTGAAGCTGAGCGCAAAAACAGGTTGCGTAAAGAAGAG CGCCGTAAACTTCGCGTGACCTGGAAGCCGGATGATGCTCTTACCGAAGTCCGACTATTTACCCACGACCCGGAT GAAGAATTAGGTCCCGGCGATGGGTCATTGCGCTCACGAGGAGACGTTAAAGGTGAAGGTAGTGTTCTCAAGCTT CACAAAGATATGGACGAATTGGAAGAAGAGGATCTCGGTGAGACCGTATTTCAAGACGGTTATACTCTTTCAATG GTCGATTTCGATTTCGAGGAATCAAATGATGGCAGTTTCATCAAGCGCGGCGGCACTCAGCTGCCCACGAGTCCC GAGAGGGAGGCTCAGGAGCATCGGGAATCTACTACCCTTATGGTCTTCTATACCTCTCCTGCTGACATGCCCGAC ACACCAAAGGAACCACCAGCTCCTGACCCCGACGATATTGTTACCGATGTATTGCCTTTCGGAGAGTTGCCCGAC CTGGTCAAGGTCCGCCAGGAACGTTACTACTCCTACATGAATCCCAAGCCTACGACTCCCCAACCAACCCAACAA CCGCAGCGACCTACTCCCGGAGACAGTGGATTTGACATCTCCAATTTGCTCAAGATCATCCAGGGTGTTCCTGGA CAGGCGCAACCAATCCCAGCCCCGCAGGCAACTCAACCCGGGGGCATGCCGGATCTCGAGAGGACCATCAGCATG TTCCGTCAACAACAACCTCAACCACAGGTCCCCCCGGCTCCACCAGTACCAATTCCACAGCCGCAAGGCCTTGAC TTCAACGCGATATTGAATGTTATGAAACAAATGCAGGCGCCGCCTGCATATTCCCAGCCCCAGCAATCGCAATCA GCAATGGCACCTAACCTGGGCGCCATGTTCGCACAATTCGGTGGGCAGAACCAAAACGGTGCTCTCCCATTCCGA CAGCAAGGGCATGACTATGAAGACCCAGAGCGCAAGCGCGGCCGCGAGGGCGGTTATTATGACGACAATTCTAAC CCCGAATCGTGGAGCCGCTCGAAACGAACCAAATTTGGCGCCAACGAGGCCAAGCCTTATAAGGTGGGACTAGTT GCTTGCAGATTTTGGGCCGAGGGCAAGTGTCGCAAAGGCGACAACTGCACTTTCCGCCACGATCCTCTCTAA
Gene	>Pro_DTO377G3_2|g1800.t1 ATGGAGCAATCAGCTCAAACCCCTATTCAGGGGTTATCTCATGGGAATTCACTACCTGCTGATTACTGGAGCACA CTTGACCCCGCCTACCCTGATCCCGAGCAGCAGCTTCAGCAGCCATCTCAACCCCAGCACCAGCCTCAACAGCAG CACGATTCTGCATCGCAACCAACACCTCTTGGGATCGGATGGGACCATCCTGTTTTTCAACAGCAGCCAAGAGAG CTAGCCTCACGACCAGATCCGAACCATGGCATTTACTCATCAGTGCATCAGCCTTGGCAGCAAGCAAATCCTTTG CAACAGCCACCGCAACGAGGATATGGAGCTTCGCATCAGTATCAGATACATTCCCAAGCTCCTCATTTCCAACAA GATGGGTTATCTTTTGACTCTCGTCCCCTGAGCGCCTCCGAATCTTCGTCATTTCCATCATTTCCCTACCAGCAA AATTATTTCCATCCACAAAACACACACATCTCAGTGCCAGACACATTTCCTGAAGCACCCGCGCAGCAGAGAATA CAGCCACGGCAACAGCAACAACCCCAGTCGTCAATTTCTGCATACTCTTTACCTCAAAGCTACTCCTCGGAAATG CTGGTAAGCCGACCCTAAATGCCCTTCGTGGTGACCGTGACTCTAACTTGAGGCAGCAAAACACAATTGATTTGA CCAACGATTACTCCGATTCAGACCCGAATGTCACCATCAACCCCCAGTTCCTAAATTCTATCCCGCAGGCATTCA ATCCACAGCAGTCTTCGTTGACAAACAACTTTATTCAGGGAATTCCTGCAGACCTCAAACAACAAGGGAGCGAAC AGTAAGTTATCACTTTACTTTATGGATGTTTAAAATGCACTTGCTGATTTTTAGAAGGGGTAGGCAATTTAATTA CTACCAGCATGATCTTTCAGTCCAGTCGCATATGGCACTAAATGGCAACCCGGTGATTCCACCTGGAGGTATGCG TAGACCAGTTGAAACCCATTGTGTTAGACTTAATACTGACTTTCATAGGATTACCAGTACTGCAAGTTGTAGTCC CCGATAAGAAGGGCGCTTCTAATAAGCAGCAAACGAAGAAGACTTCTCAAAATGGCCGAATGAGAACTTTATCTA AGTCAGAAAGTGAAAGTTCGGATGAATCCGATCTTGAGATTGAAGCACCTGACGAGCCTTCTCCTATCCCTCCGA TCCGCCCGACTGAGCCCGAGGCTGCAGCGCAATATGATACCCTCCAAGCCGTGTGGTCACCGAGGAACAAATGGC CTGGTCCTGAGAAGGTCAAGAATGCGCTGGTAGCCTACAAAGAGCTTGTCAAAGGATTAAGAGATGCGTGGAAGG AACAAGTTCAGGCCATGAAGCTGGCTGAAAACCAAGATGACAACCAGAAAGCAACACAACTTAAGGAGAAAGTCA CTTCGCAACGTCGTACCATGGATAAAATTGCGACCACGACACTGGAAATGGGTCATCCCAATATTGTTGAGAAGT ATGTATCCCTCTCCTCTCCCAACCCCTATATCTTCCCTCCCTTCCATCTGGCTGTAATGGCCACAGAAATCCCGA AGCTGTTTGAGAAACCTATAAATATTCTTGGAAGCATTGAATATGAAAGCACTGTCACGGGCTAGAATAAAGGCT CATCGCTCTATTCGCCGGTGGCAAGGCTTGATTATACATGCGTGTCCTAAGTACATATATAAGAGTATCAGATGG AGCAAAATGGTTCCATCATATGGATTCTCAGATATGCCCTTCAGAAGCTATCTGTGAATCTCTTTGGGGGGAATC TCTCCTATCTAGAAATTGGCTCAAACTTGCAGCTTTGTGTGCCAAAATTCTTGAAACGTTATAGTTGAGCTCAAA TGACTGATCGTTAATTTCATGTAGGCTGGGAGAGCATCCTATGGTTGTGGCGGCTTTATATTCGTTCTTACTCGA TCGTTTCCAAGCAGCAGACTTTGCTGGGACTCTGACTATTAATTTGCTTTCGGTAAGTTTAACGTTTGTCTCCTC TTATGTCAAATGCAATGGCTAACATGGAATAAGCTCTTCTCGCGTTTCTCGACTTTGACAGAAGACCTGATGCAA AAGACCAATCTTTCCAAATTGTTGCCAAAGTTTCTCAAAAAGGGTGGCCAGCAGGTTAAGGACCTCACACAGAAG ATATTGGATAATGCTGCGGCCTCTACGAAGCGTAAACACGAGAGTGAAAAGTCCGCCAAGGAAGACTCTCATCCA AGGAGCGTTTTAGCAGATCAGCCTAAAGGAGAGGCTGGAGTGAAGCGACCCCGTGAGGCGGATAGCAATCTGCAG CCTGGCACAAAACGAATGGCAGTTACCAATCCCTTGAAGGATGTGAATAAACATGCACCCGCAAGCAATGGACCG GTCAAAGGAGCACAAAGTAGTAAGCCAACCGGCGCTGCAGTGCTGCGCCCTAAAGCCAATATCGTGGCCCCTAAG CCAACAAGTCTCTTTGGCACTTTAAGTTCGGCGTCCAAGAGACCCGGGACCACAAATGCGGATAGGGCTGCTGCC GCCGCCGCAGCAAAGCCAACGTATGTACCCACGAAGGAACTGTTTCCGAAGTTCATCTGTACTAACCTTTCAAAT AGTGCTGCTTCCGAAAAGGAAAAGACACCAGCCCCAAAGCCATCTTTCTCATTTGGCGACATTATGGCCGACTTG AACAAACCCAAGCAGGCACCAAGCCCCAAGCCCGCCGAAGATCAGCCCCCGGAGACTGAAGCTGAGCGCAAAAAC AGGTTGCGTAAAGAAGAGCGCCGTAAACTTCGCGTGACCTGGAAGCCGGATGATGCTCTTACCGAAGTCCGACTA TTTACCCACGACCCGGATGAAGAATTAGGTCCCGGCGATGGGTCATTGCGCTCACGAGGAGACGTTAAAGGTGAA GGTAGTGTTCTCAAGCTTCACAAAGATATGGACGAATTGGAAGAAGAGGATCTCGGTGAGACCGTATTTCAAGAC GGTTATACTCTTTCAAGTAAGTTATTCTTCCAAATGCATCTTCAATTCCTATTGACCATTATAGTGGTCGATTTC GATTTCGAGGAATCAAATGATGGCAGTTTCATCAAGCGCGGCGGCACTCAGCTGCCCACGAGTCCCGAGAGGGAG GCTCAGGAGCATCGGGAATCTACTACCCTTATGGTCTTCTATACCTCTCCTGCTGACATGCCCGACACACCAAAG GAACCACCAGCTCCTGACCCCGACGATATTGTTACCGATGTATTGCCTTTCGGAGAGTTGCCCGACCTGGTCAAG GTATGCTATACTTCTGATAACACTACGATCCAATACTTACAAAGACACTACAGGTCCGCCAGGAACGTTACTACT CCTACATGAATCCCAAGCCTACGACTCCCCAACCAACCCAACAACCGCAGCGACCTACTCCCGGAGACAGTGGAT TTGACATCTCCAATTTGCTCAAGATCATCCAGGGTGTTCCTGGACAGGCGCAACCAATCCCAGCCCCGCAGGCAA CTCAACCCGGGGGCATGCCGGATCTCGAGAGGACCATCAGCATGTTCCGTCAACAACAACCTCAACCACAGGTCC CCCCGGCTCCACCAGTACCAATTCCACAGCCGCAAGGCCTTGACTTCAACGCGATATTGAATGTTATGAAACAAA TGCAGGCGCCGCCTGCATATTCCCAGCCCCAGCAATCGCAATCAGCAATGGCACCTAACCTGGGCGCCATGTTCG CACAATTCGGTGGGCAGAACCAAAACGGTGCTCTCCCATTCCGACAGCAAGGGCATGACTATGAAGACCCAGAGC GCAAGCGCGGCCGCGAGGGCGGTTATTATGACGACAATTCTAACCCCGAATCGTGGAGCCGCTCGAAACGAACCA AATTTGGCGCCAACGAGGCCAAGCCTGTAGGTACACTGCAGCATTTTTTTGATAAGCAGTTGGCTAATTCTTTTG AAATAGTATAAGGTGGGACTAGTTGCTTGCAGATTTTGGGCCGAGGGCAAGTGTCGCAAAGGCGACAACTGCACT TTCCGCCACGATCCTCTCTAA