Fungal Genomics

Agaricus bisporus var bisporus H39 Agaricus bisporus var bisporus H97 Agaricus bisporus var burnettii H119p4 Aspergillus niger CBS 112.32 Aspergillus niger CBS 113.50 Aspergillus niger CBS 115988 Aspergillus niger CBS 115989 Aspergillus niger CBS 118.52 Aspergillus niger CBS 124.48 Aspergillus niger CBS 131.52 Aspergillus niger CBS 133816 Aspergillus niger CBS 147320 Aspergillus niger CBS 147321 Aspergillus niger CBS 147322 Aspergillus niger CBS 147323 Aspergillus niger CBS 147324 Aspergillus niger CBS 147343 Aspergillus niger CBS 147344 Aspergillus niger CBS 147345 Aspergillus niger CBS 147346 Aspergillus niger CBS 147347 Aspergillus niger CBS 147352 Aspergillus niger CBS 147353 Aspergillus niger CBS 147371 Aspergillus niger CBS 147482 Aspergillus niger CBS 630.78 Aspergillus niger CBS 769.97 Niveomyces coronatus CBS 149186 Ophiocordyceps australis 1348a (Ghana) Ophiocordyceps australis map64 (Brazil) Ophiocordyceps camponoti-floridani Ophiocordyceps camponoti-rufipedis Ophiocordyceps kimflemingae Ophiocordyceps subramaniannii Penicillium roqueforti DTO002I6 Penicillium roqueforti DTO003C3 Penicillium roqueforti DTO003H1 (CBS 147308) Penicillium roqueforti DTO006G1 Penicillium roqueforti DTO006G7 Penicillium roqueforti DTO012A1 Penicillium roqueforti DTO012A2 (CBS 147309) Penicillium roqueforti DTO012A6 (CBS 147310) Penicillium roqueforti DTO012A7 Penicillium roqueforti DTO012A8 Penicillium roqueforti DTO012A9 Penicillium roqueforti DTO013E5 Penicillium roqueforti DTO013F2 Penicillium roqueforti DTO013F5 (CBS 147311) Penicillium roqueforti DTO027I6 Penicillium roqueforti DTO032C6 Penicillium roqueforti DTO039G3 Penicillium roqueforti DTO046C5 Penicillium roqueforti DTO070G2 (CBS 147317) Penicillium roqueforti DTO081F9 (CBS 147318) Penicillium roqueforti DTO101D6 (CBS 147325) Penicillium roqueforti DTO102I9 (CBS 147326) Penicillium roqueforti DTO126G2 (CBS 147330) Penicillium roqueforti DTO127F7 (CBS 147331) Penicillium roqueforti DTO127F9 (CBS 147332) Penicillium roqueforti DTO130C1 (CBS 147333) Penicillium roqueforti DTO163C3 (CBS 147337) Penicillium roqueforti DTO163F5 (CBS 147338) Penicillium roqueforti DTO163G4 (CBS 147339) Penicillium roqueforti DTO265D5 (CBS 147372) Penicillium roqueforti DTO369A1 (CBS 147354) Penicillium roqueforti DTO375B1 (CBS 147355) Penicillium roqueforti DTO377G2 (LCP 96.3914a) Penicillium roqueforti LCP96 04111 Rhodonia placenta FPRL280 Torrubiellomyces zombiae CBS 149187

General Properties

Protein ID	Pro_DTO377G3_2|g1446.t1
Gene name
Location	scaffold_01:3807938..3811267
Strand	-
Gene length (bp)	3329
Transcript length (bp)	3279
Coding sequence length (bp)	3279
Protein length (aa)	1093

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PFAM Domains

PFAM Domain ID	Short name	Long name	E-value	Start	End
PF01074	Glyco_hydro_38N	Glycosyl hydrolases family 38 N-terminal domain	5.6E-88	285	550
PF07748	Glyco_hydro_38C	Glycosyl hydrolases family 38 C-terminal domain	7.8E-58	730	938
PF09261	Alpha-mann_mid	Alpha mannosidase middle domain	4.7E-27	557	656
PF17677	Glyco_hydro38C2	Glycosyl hydrolases family 38 C-terminal beta sandwich domain	3.0E-10	1022	1089

GO

GO Term	Description	Terminal node
GO:0004559	alpha-mannosidase activity	Yes
GO:0006013	mannose metabolic process	Yes
GO:0005996	monosaccharide metabolic process	No
GO:0016798	hydrolase activity, acting on glycosyl bonds	No
GO:0008150	biological_process	No
GO:0044238	primary metabolic process	No
GO:0008152	metabolic process	No
GO:0044281	small molecule metabolic process	No
GO:0015923	mannosidase activity	No
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	No
GO:0005975	carbohydrate metabolic process	No
GO:0019318	hexose metabolic process	No
GO:0003674	molecular_function	No
GO:0003824	catalytic activity	No
GO:0016787	hydrolase activity	No
GO:0071704	organic substance metabolic process	No

SignalP

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SignalP signal predicted	Location (based on Ymax)	D score (significance: > 0.45)
No	1 - 12	0.45

Transmembrane Domains

(None)

Transcription Factor Class

(None)

Expression data

Analysis 1: Genome-wide gene expression in conidia of Penicillium roqueforti during growth at various temperatures and for various amounts of time. Published in Punt et al., 2020.

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Sequences

Type of sequence	Sequence
Locus	Download genbank file of locus The gene with 5 kb flanks (if sufficient flanking sequence is available). For use in cloning design programs. NOTE: features (genes or exons) that are only partially contained within the sequence are completely excluded.
Protein	>Pro_DTO377G3_2|g1446.t1 MGGEVPSRPAPPALPQLAERPVGQRIKKIYTDRLNQFTSNGQYEGQNLVSKYHEATNSDEDHVKLSVYSVPDLQR PTFKEATSQEFKPTRIGASFGPSWSTHWFRIHLTVPEDMLQREHLEFHWDANNEGLIWTEDGHPLQGLTGGGERT EFVLPKQWCDGKEHTFYIEMACNGMFGNAPGGDSIQPPNPDKQFTLSTARITAVNLAARALFYDFWIIGDAAREF PGDSWESHEANVVANSIIDTFIAGNGSNDSINEGRKVARKYLGDKVDSSDVYDTDTQPIVYAIGHCHIDTCWLWP WAETKRKVARSWSNQCDLMERYPEHRFACSQAQQFKWLKQYYPSVFDRVKRWVRKGNFQPIGGSWVEHDTNMPSG ESLVRQFLYGQRFFEANFGKRCTTFWLPDTFGYSTQIPQICRLAGMSRFFTQKLSWNNINNFPHTTFQWVALDGS QVLCHMAPAETYTAEAHFGDVKRSVTQHKSLDTDKSSLLVFGKGDGGGGPTFGHLEKLRRCRGLSDQVGSLPRVK MGESVDDFFAKLETKAASGTDFATWYGELYFELHRGTYTTQANNKRNNRKAEFLLREIELLATFATIKASNDGYR YPKKEIDEMWEGTLLCQFHDCLPGSSIEMCYDDSDKLYAEIFEIGAKLRKNALKALGLTSDVTGGNFMALNTLPW ARSEVVAIPPAVSAYNGSRYAVAAGTTGVMQVQRADFKTTTSVTVTEIKSGVFRLENGKLRVDVHDGVITSLYDV QADREIVAKDRKAGQLVIFDDKPLYWQAWDVEVFHIESRKELPGGKTTIVENDPHRVSVMTETQISEKSWIKTTI SLSASTSDEPSYVEMESEVEWQETMKFLKVEFPVDIVNTEASYETQYGIVRRPTHYNTSWDMAKFEVCCHKWADL SENGYGVSILNDSKYGFATCGNLMRLSLLRAPKAPDAHADMGRHHIRYAILPHAGALDARTIRAGFNFNNPLIVE KAGPKASASNALFKSLSIKGAPSLILDVVKRGEDDVDVSWDGVPTRPGKSVILRVYESLGGKARGTIETSLPVKN VFKCNILEDDENHGLDIESAGGLSAIKIELRAFEVATYRLQL*
Coding	>Pro_DTO377G3_2|g1446.t1 ATGGGTGGGGAAGTTCCCTCTCGCCCCGCTCCTCCAGCTTTACCCCAGTTAGCTGAACGTCCGGTCGGCCAACGT ATCAAGAAGATCTATACCGATAGATTGAATCAGTTCACGTCGAACGGCCAGTACGAAGGCCAAAACCTTGTCTCA AAGTACCACGAAGCCACAAACTCGGACGAAGATCATGTCAAGCTCTCTGTTTACTCGGTTCCGGACCTGCAGCGA CCGACCTTCAAAGAGGCGACCTCTCAGGAATTCAAGCCCACTCGCATAGGCGCCTCCTTTGGCCCCAGTTGGTCC ACACATTGGTTCCGGATTCACCTCACAGTGCCCGAGGACATGCTCCAACGGGAGCATCTAGAGTTCCACTGGGAT GCCAACAACGAAGGCCTGATCTGGACAGAGGACGGACACCCGCTGCAGGGCTTGACTGGAGGCGGAGAACGGACC GAGTTTGTTCTCCCAAAACAATGGTGCGATGGGAAAGAGCATACCTTCTACATTGAAATGGCTTGCAATGGCATG TTCGGCAATGCTCCTGGTGGCGATTCGATCCAGCCACCAAATCCCGATAAACAGTTCACGCTCAGCACTGCGCGA ATCACCGCGGTAAACCTGGCTGCCCGGGCGCTTTTCTATGATTTCTGGATTATTGGTGACGCCGCCCGGGAATTC CCAGGGGATTCATGGGAGTCGCATGAAGCCAATGTTGTGGCCAATTCTATCATCGATACTTTCATTGCGGGCAAC GGAAGCAATGATTCTATCAACGAGGGGCGGAAGGTTGCTAGAAAGTACCTTGGCGACAAAGTAGACTCATCCGAT GTTTACGACACAGACACGCAGCCGATAGTTTATGCCATTGGCCATTGTCATATTGATACTTGCTGGCTGTGGCCT TGGGCTGAGACCAAGCGAAAGGTAGCACGGTCATGGTCTAACCAATGTGATCTGATGGAACGATATCCTGAGCAC CGTTTTGCTTGTTCTCAGGCTCAACAATTCAAATGGCTCAAGCAGTACTACCCATCCGTTTTTGATCGTGTGAAG CGCTGGGTAAGGAAGGGCAACTTCCAGCCCATCGGTGGGAGCTGGGTCGAGCACGATACAAATATGCCAAGTGGA GAGTCGCTGGTCAGACAGTTCTTGTATGGACAGCGATTCTTCGAGGCAAACTTCGGTAAGCGATGCACAACTTTC TGGTTGCCAGATACGTTCGGGTACTCTACACAGATCCCTCAGATATGCCGCCTGGCTGGGATGAGCCGTTTCTTC ACCCAGAAGCTCAGCTGGAACAACATCAATAACTTCCCTCACACTACATTCCAGTGGGTTGCGCTTGATGGTAGT CAAGTCTTGTGCCACATGGCTCCTGCTGAGACCTACACAGCTGAAGCGCATTTCGGTGATGTCAAACGCAGTGTC ACTCAGCATAAGTCTCTAGACACGGACAAGTCATCGCTGCTTGTATTCGGAAAAGGCGACGGAGGTGGTGGTCCG ACTTTTGGGCACCTCGAAAAGCTGCGTCGATGCCGCGGTCTCAGTGATCAGGTCGGCTCATTGCCCCGAGTGAAA ATGGGCGAGTCGGTAGATGATTTCTTTGCAAAGTTGGAGACAAAGGCTGCCTCTGGCACTGATTTTGCTACCTGG TACGGCGAGCTTTACTTTGAGTTGCACCGTGGAACATACACCACTCAAGCGAACAATAAGCGCAATAACCGCAAG GCCGAGTTTTTGCTGCGTGAGATTGAGCTTCTCGCGACATTCGCTACCATCAAGGCTTCTAATGATGGATATCGG TATCCCAAAAAGGAGATTGATGAGATGTGGGAAGGAACCCTCCTTTGCCAATTCCATGATTGCTTGCCGGGTAGC TCCATCGAAATGTGCTATGATGACTCAGACAAGTTGTATGCCGAAATCTTTGAGATTGGAGCTAAGCTGCGAAAG AATGCCCTCAAGGCTTTGGGACTCACTAGCGATGTCACGGGTGGAAATTTCATGGCCCTCAATACCTTGCCATGG GCCCGATCAGAAGTGGTCGCAATTCCTCCAGCAGTGTCCGCATACAATGGATCCAGATATGCTGTGGCTGCTGGT ACAACTGGAGTGATGCAAGTTCAGCGGGCTGACTTCAAAACAACCACTTCGGTGACCGTTACTGAGATCAAATCT GGTGTCTTCCGCCTGGAGAACGGTAAACTTAGGGTTGATGTCCATGACGGGGTTATCACATCCTTGTACGATGTG CAAGCCGATAGAGAAATCGTCGCAAAGGACCGCAAGGCTGGCCAACTTGTTATCTTCGACGACAAGCCTCTTTAC TGGCAAGCATGGGATGTCGAGGTGTTCCATATTGAGTCACGAAAGGAGTTGCCCGGGGGTAAGACGACCATTGTA GAAAATGACCCACACCGAGTGAGTGTCATGACTGAGACACAGATCAGCGAGAAGAGCTGGATCAAGACCACGATC AGCCTGTCGGCATCCACATCCGATGAGCCCTCATACGTGGAAATGGAGAGCGAGGTGGAATGGCAAGAGACGATG AAGTTCCTGAAGGTTGAGTTCCCAGTTGATATCGTCAACACCGAAGCATCCTACGAGACCCAGTATGGCATCGTT AGGCGCCCGACGCATTATAACACAAGTTGGGATATGGCCAAATTCGAAGTCTGCTGTCACAAATGGGCCGACCTC TCCGAAAACGGCTACGGAGTCTCCATCCTAAACGACTCTAAATACGGCTTCGCAACATGCGGTAACCTGATGCGC TTATCGCTTCTCCGTGCCCCCAAGGCGCCAGATGCCCACGCCGACATGGGTCGCCACCACATTCGCTACGCAATT CTTCCCCACGCCGGTGCCCTTGATGCCCGAACAATCCGCGCAGGCTTCAATTTCAATAACCCACTCATTGTTGAG AAAGCCGGCCCTAAAGCATCTGCTTCCAATGCTTTGTTTAAATCTCTATCTATCAAGGGCGCGCCATCCTTGATT CTAGATGTTGTCAAGCGCGGCGAGGATGATGTTGACGTTTCCTGGGATGGTGTTCCTACCCGTCCTGGAAAGAGT GTTATTCTGCGTGTCTATGAATCGCTTGGTGGTAAGGCTCGCGGTACCATTGAGACCTCACTGCCCGTGAAGAAT GTTTTCAAGTGCAATATTCTCGAGGATGATGAGAACCACGGGCTTGATATTGAATCTGCAGGCGGTCTTTCCGCG ATCAAGATTGAGTTGAGGGCGTTTGAGGTCGCTACATACCGACTGCAGCTGTGA
Transcript	>Pro_DTO377G3_2|g1446.t1 ATGGGTGGGGAAGTTCCCTCTCGCCCCGCTCCTCCAGCTTTACCCCAGTTAGCTGAACGTCCGGTCGGCCAACGT ATCAAGAAGATCTATACCGATAGATTGAATCAGTTCACGTCGAACGGCCAGTACGAAGGCCAAAACCTTGTCTCA AAGTACCACGAAGCCACAAACTCGGACGAAGATCATGTCAAGCTCTCTGTTTACTCGGTTCCGGACCTGCAGCGA CCGACCTTCAAAGAGGCGACCTCTCAGGAATTCAAGCCCACTCGCATAGGCGCCTCCTTTGGCCCCAGTTGGTCC ACACATTGGTTCCGGATTCACCTCACAGTGCCCGAGGACATGCTCCAACGGGAGCATCTAGAGTTCCACTGGGAT GCCAACAACGAAGGCCTGATCTGGACAGAGGACGGACACCCGCTGCAGGGCTTGACTGGAGGCGGAGAACGGACC GAGTTTGTTCTCCCAAAACAATGGTGCGATGGGAAAGAGCATACCTTCTACATTGAAATGGCTTGCAATGGCATG TTCGGCAATGCTCCTGGTGGCGATTCGATCCAGCCACCAAATCCCGATAAACAGTTCACGCTCAGCACTGCGCGA ATCACCGCGGTAAACCTGGCTGCCCGGGCGCTTTTCTATGATTTCTGGATTATTGGTGACGCCGCCCGGGAATTC CCAGGGGATTCATGGGAGTCGCATGAAGCCAATGTTGTGGCCAATTCTATCATCGATACTTTCATTGCGGGCAAC GGAAGCAATGATTCTATCAACGAGGGGCGGAAGGTTGCTAGAAAGTACCTTGGCGACAAAGTAGACTCATCCGAT GTTTACGACACAGACACGCAGCCGATAGTTTATGCCATTGGCCATTGTCATATTGATACTTGCTGGCTGTGGCCT TGGGCTGAGACCAAGCGAAAGGTAGCACGGTCATGGTCTAACCAATGTGATCTGATGGAACGATATCCTGAGCAC CGTTTTGCTTGTTCTCAGGCTCAACAATTCAAATGGCTCAAGCAGTACTACCCATCCGTTTTTGATCGTGTGAAG CGCTGGGTAAGGAAGGGCAACTTCCAGCCCATCGGTGGGAGCTGGGTCGAGCACGATACAAATATGCCAAGTGGA GAGTCGCTGGTCAGACAGTTCTTGTATGGACAGCGATTCTTCGAGGCAAACTTCGGTAAGCGATGCACAACTTTC TGGTTGCCAGATACGTTCGGGTACTCTACACAGATCCCTCAGATATGCCGCCTGGCTGGGATGAGCCGTTTCTTC ACCCAGAAGCTCAGCTGGAACAACATCAATAACTTCCCTCACACTACATTCCAGTGGGTTGCGCTTGATGGTAGT CAAGTCTTGTGCCACATGGCTCCTGCTGAGACCTACACAGCTGAAGCGCATTTCGGTGATGTCAAACGCAGTGTC ACTCAGCATAAGTCTCTAGACACGGACAAGTCATCGCTGCTTGTATTCGGAAAAGGCGACGGAGGTGGTGGTCCG ACTTTTGGGCACCTCGAAAAGCTGCGTCGATGCCGCGGTCTCAGTGATCAGGTCGGCTCATTGCCCCGAGTGAAA ATGGGCGAGTCGGTAGATGATTTCTTTGCAAAGTTGGAGACAAAGGCTGCCTCTGGCACTGATTTTGCTACCTGG TACGGCGAGCTTTACTTTGAGTTGCACCGTGGAACATACACCACTCAAGCGAACAATAAGCGCAATAACCGCAAG GCCGAGTTTTTGCTGCGTGAGATTGAGCTTCTCGCGACATTCGCTACCATCAAGGCTTCTAATGATGGATATCGG TATCCCAAAAAGGAGATTGATGAGATGTGGGAAGGAACCCTCCTTTGCCAATTCCATGATTGCTTGCCGGGTAGC TCCATCGAAATGTGCTATGATGACTCAGACAAGTTGTATGCCGAAATCTTTGAGATTGGAGCTAAGCTGCGAAAG AATGCCCTCAAGGCTTTGGGACTCACTAGCGATGTCACGGGTGGAAATTTCATGGCCCTCAATACCTTGCCATGG GCCCGATCAGAAGTGGTCGCAATTCCTCCAGCAGTGTCCGCATACAATGGATCCAGATATGCTGTGGCTGCTGGT ACAACTGGAGTGATGCAAGTTCAGCGGGCTGACTTCAAAACAACCACTTCGGTGACCGTTACTGAGATCAAATCT GGTGTCTTCCGCCTGGAGAACGGTAAACTTAGGGTTGATGTCCATGACGGGGTTATCACATCCTTGTACGATGTG CAAGCCGATAGAGAAATCGTCGCAAAGGACCGCAAGGCTGGCCAACTTGTTATCTTCGACGACAAGCCTCTTTAC TGGCAAGCATGGGATGTCGAGGTGTTCCATATTGAGTCACGAAAGGAGTTGCCCGGGGGTAAGACGACCATTGTA GAAAATGACCCACACCGAGTGAGTGTCATGACTGAGACACAGATCAGCGAGAAGAGCTGGATCAAGACCACGATC AGCCTGTCGGCATCCACATCCGATGAGCCCTCATACGTGGAAATGGAGAGCGAGGTGGAATGGCAAGAGACGATG AAGTTCCTGAAGGTTGAGTTCCCAGTTGATATCGTCAACACCGAAGCATCCTACGAGACCCAGTATGGCATCGTT AGGCGCCCGACGCATTATAACACAAGTTGGGATATGGCCAAATTCGAAGTCTGCTGTCACAAATGGGCCGACCTC TCCGAAAACGGCTACGGAGTCTCCATCCTAAACGACTCTAAATACGGCTTCGCAACATGCGGTAACCTGATGCGC TTATCGCTTCTCCGTGCCCCCAAGGCGCCAGATGCCCACGCCGACATGGGTCGCCACCACATTCGCTACGCAATT CTTCCCCACGCCGGTGCCCTTGATGCCCGAACAATCCGCGCAGGCTTCAATTTCAATAACCCACTCATTGTTGAG AAAGCCGGCCCTAAAGCATCTGCTTCCAATGCTTTGTTTAAATCTCTATCTATCAAGGGCGCGCCATCCTTGATT CTAGATGTTGTCAAGCGCGGCGAGGATGATGTTGACGTTTCCTGGGATGGTGTTCCTACCCGTCCTGGAAAGAGT GTTATTCTGCGTGTCTATGAATCGCTTGGTGGTAAGGCTCGCGGTACCATTGAGACCTCACTGCCCGTGAAGAAT GTTTTCAAGTGCAATATTCTCGAGGATGATGAGAACCACGGGCTTGATATTGAATCTGCAGGCGGTCTTTCCGCG ATCAAGATTGAGTTGAGGGCGTTTGAGGTCGCTACATACCGACTGCAGCTGTGA
Gene	>Pro_DTO377G3_2|g1446.t1 ATGGGTGGGGAAGTTCCCTCTCGCCCCGCTCCTCCAGCTTTACCCCAGTTAGCTGAACGTCCGGTCGGCCAACGT ATCAAGAAGATCTATACCGATAGATTGAATCAGTTCACGTCGAACGGCCAGTACGAAGGCCAAAACCTTGTCTCA AAGTACCACGAAGCCACAAACTCGGACGAAGATCATGTCAAGCTCTCTGTTTACTCGGTTCCGGACCTGCAGCGA CCGACCTTCAAAGAGGCGACCTCTCAGGAATTCAAGCCCACTCGCATAGGCGCCTCCTTTGGCCCCAGTTGGTCC ACACATTGGTTCCGGATTCACCTCACAGTGCCCGAGGACATGCTCCAACGGGAGCATCTAGAGTTCCACTGGGAT GCCAACAACGAAGGCCTGATCTGGACAGAGGACGGACACCCGCTGCAGGGCTTGACTGGAGGCGGAGAACGGACC GAGTTTGTTCTCCCAAAACAATGGTGCGATGGGAAAGAGCATACCTTCTACATTGAAATGGCTTGCAATGGCATG TTCGGCAATGCTCCTGGTGGCGATTCGATCCAGCCACCAAATCCCGATAAACAGTTCACGCTCAGCACTGCGCGA ATCACCGCGGTAAACCTGGCTGCCCGGGCGCTTTTCTATGATTTCTGGATTATTGGTGACGCCGCCCGGGAATTC CCAGGGGATTCATGGGAGTCGCATGAAGCCAATGTTGTGGCCAATTCTATCATCGATACTTTCATTGCGGGCAAC GGAAGCAATGATTCTATCAACGAGGGGCGGAAGGTTGCTAGAAAGTACCTTGGCGACAAAGTAGACTCATCCGAT GTTTACGACACAGACACGCAGCCGATAGTTTATGCCATTGGCCATTGTCATATTGATACTTGCTGGCTGTGGCCT TGGGCTGAGACCAAGCGAAAGGTAGCACGGTCATGGTCTAACCAATGTGATCTGATGGAACGATATCCTGAGCAC CGTTTTGCTTGTTCTCAGGCTCAACAATTCAAATGGCTCAAGCAGTACTACCCATCCGTTTTTGATCGTGTGAAG CGCTGGGTAAGGAAGGGCAACTTCCAGCCCATCGGTGGGAGCTGGGTCGAGCACGATACAAATATGCCAAGTGGA GAGTCGCTGGTCAGACAGTTCTTGTATGGACAGCGATTCTTCGAGGCAAACTTCGGTAAGCGATGCACAACTTTC TGGTTGCCAGATACGTTCGGGTACTCTACACAGATCCCTCAGATATGCCGCCTGGCTGGGATGAGCCGTTTCTTC ACCCAGAAGCTCAGCTGGAACAACATCAATAACTTCCCTCACACTACATTCCAGTGGGTTGCGCTTGATGGTAGT CAAGTCTTGTGCCACATGGCTCCTGCTGAGACCTACACAGCTGAAGCGCATTTCGGTGATGTCAAACGCAGTGTC ACTCAGCATAAGTCTCTAGACACGGACAAGTCATCGCTGCTTGTATTCGGAAAAGGCGACGGAGGTGGTGGTCCG ACTTTTGGGCACCTCGAAAAGCTGCGTCGATGCCGCGGTCTCAGTGATCAGGTCGGCTCATTGCCCCGAGTGAAA ATGGGCGAGTCGGTAGATGATTTCTTTGCAAAGTTGGAGACAAAGGCTGCCTCTGGCACTGATTTTGCTACCTGG TACGGCGAGCTTTACTTTGAGTTGCACCGTGGAACATACACCACTCAAGCGAACAATAAGCGCAATAACCGCAAG GCCGAGTTTTTGCTGCGTGAGATTGAGCTTCTCGCGACATTCGCTACCATCAAGGCTTCTAATGATGGATATCGG TATCCCAAAAAGGAGATTGATGAGATGTGGGAAGGAACCCTCCTTTGCCAATTCCATGATTGCTTGCCGGGTAGC TCCATCGAAATGTGCTATGATGACTCAGACAAGTTGTATGCCGAAATCTTTGAGATTGGAGCTAAGCTGCGAAAG AATGCCCTCAAGGCTTTGGGACTCACTAGCGATGTCACGGGTGGAAATTTCATGGCCCTCAATACCTTGCCATGG GCCCGATCAGAAGTGGTCGCAATTCCTCCAGCAGTGTCCGCATACAATGGATCCAGATATGCTGTGGCTGCTGGT ACAACTGGAGTGATGCAAGTTCAGCGGGCTGACTTCAAAACAACCACTTCGGTGACCGTTACTGAGATCAAATCT GGTGTCTTCCGCCTGGAGAACGGTAAACTTAGGGTTGATGTCCATGACGGGGTTATCACATCCTTGTACGATGTG CAAGCCGATAGAGAAATCGTCGCAAAGGACCGCAAGGCTGGCCAACTTGTTATCTTCGACGACAAGCCTCTTTAC TGGCAAGCATGGGATGTCGAGGTGTTCCATATTGAGTCACGAAAGGAGTTGCCCGGGGGTAAGACGACCATTGTA GAAAATGACCCACACCGAGTGAGTGTCATGACTGAGACACAGATCAGCGAGAAGAGCTGGATCAAGACCACGATC AGCCTGTCGGCATCCACATCCGATGAGCCCTCATACGTGGAAATGGAGAGCGAGGTGGAATGGCAAGAGACGATG AAGTTCCTGAAGGTTGAGTTCCCAGTTGATATCGTCAACACCGAAGCATCCTACGAGACCCAGTATGGCATCGTT AGGCGCCCGACGCATTATAACACAAGGTATGCACCGACTTCCCATCTCCTTCACAACGATACTAAGTAATATGCA GTTGGGATATGGCCAAATTCGAAGTCTGCTGTCACAAATGGGCCGACCTCTCCGAAAACGGCTACGGAGTCTCCA TCCTAAACGACTCTAAATACGGCTTCGCAACATGCGGTAACCTGATGCGCTTATCGCTTCTCCGTGCCCCCAAGG CGCCAGATGCCCACGCCGACATGGGTCGCCACCACATTCGCTACGCAATTCTTCCCCACGCCGGTGCCCTTGATG CCCGAACAATCCGCGCAGGCTTCAATTTCAATAACCCACTCATTGTTGAGAAAGCCGGCCCTAAAGCATCTGCTT CCAATGCTTTGTTTAAATCTCTATCTATCAAGGGCGCGCCATCCTTGATTCTAGATGTTGTCAAGCGCGGCGAGG ATGATGTTGACGTTTCCTGGGATGGTGTTCCTACCCGTCCTGGAAAGAGTGTTATTCTGCGTGTCTATGAATCGC TTGGTGGTAAGGCTCGCGGTACCATTGAGACCTCACTGCCCGTGAAGAATGTTTTCAAGTGCAATATTCTCGAGG ATGATGAGAACCACGGGCTTGATATTGAATCTGCAGGCGGTCTTTCCGCGATCAAGATTGAGTTGAGGGCGTTTG AGGTCGCTACATACCGACTGCAGCTGTGA