© 2022 - Robin Ohm - Utrecht University - The Netherlands
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| Protein ID | Ophun1|4757 |
| Gene name | |
| Location | Contig_446:6651..10666 |
| Strand | + |
| Gene length (bp) | 4015 |
| Transcript length (bp) | 3540 |
| Coding sequence length (bp) | 3540 |
| Protein length (aa) | 1180 |
| PFAM Domain ID | Short name | Long name | E-value | Start | End |
|---|---|---|---|---|---|
| PF14027 | Questin_oxidase | Questin oxidase-like | 3.8E-69 | 61 | 369 |
| PF03215 | Rad17 | Rad17 P-loop domain | 5.3E-23 | 535 | 710 |
| Swissprot ID | Swissprot Description | Start | End | E-value |
|---|---|---|---|---|
| sp|P50531|RAD17_SCHPO | Checkpoint protein rad17 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=rad17 PE=1 SV=1 | 535 | 987 | 1.0E-37 |
| sp|Q6NXW6|RAD17_MOUSE | Cell cycle checkpoint protein RAD17 OS=Mus musculus GN=Rad17 PE=1 SV=2 | 537 | 1002 | 2.0E-36 |
| sp|Q9XT62|RAD17_CHLAE | Cell cycle checkpoint protein RAD17 OS=Chlorocebus aethiops GN=RAD17 PE=1 SV=1 | 540 | 995 | 2.0E-35 |
| sp|Q5R652|RAD17_PONAB | Cell cycle checkpoint protein RAD17 OS=Pongo abelii GN=RAD17 PE=2 SV=1 | 540 | 995 | 7.0E-35 |
| sp|O75943|RAD17_HUMAN | Cell cycle checkpoint protein RAD17 OS=Homo sapiens GN=RAD17 PE=1 SV=2 | 540 | 995 | 8.0E-34 |
| Swissprot ID | Swissprot Description | Start | End | E-value |
|---|---|---|---|---|
| sp|P50531|RAD17_SCHPO | Checkpoint protein rad17 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=rad17 PE=1 SV=1 | 535 | 987 | 1.0E-37 |
| sp|Q6NXW6|RAD17_MOUSE | Cell cycle checkpoint protein RAD17 OS=Mus musculus GN=Rad17 PE=1 SV=2 | 537 | 1002 | 2.0E-36 |
| sp|Q9XT62|RAD17_CHLAE | Cell cycle checkpoint protein RAD17 OS=Chlorocebus aethiops GN=RAD17 PE=1 SV=1 | 540 | 995 | 2.0E-35 |
| sp|Q5R652|RAD17_PONAB | Cell cycle checkpoint protein RAD17 OS=Pongo abelii GN=RAD17 PE=2 SV=1 | 540 | 995 | 7.0E-35 |
| sp|O75943|RAD17_HUMAN | Cell cycle checkpoint protein RAD17 OS=Homo sapiens GN=RAD17 PE=1 SV=2 | 540 | 995 | 8.0E-34 |
| sp|P32641|RAD24_YEAST | Checkpoint protein RAD24 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RAD24 PE=1 SV=1 | 514 | 854 | 3.0E-20 |
| sp|Q9MBA3|RAD17_ARATH | Cell cycle checkpoint protein RAD17 OS=Arabidopsis thaliana GN=RAD17 PE=2 SV=1 | 541 | 910 | 1.0E-18 |
| sp|Q9HIP7|RFCL_THEAC | Replication factor C large subunit OS=Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165) GN=rfcL PE=3 SV=1 | 538 | 800 | 7.0E-08 |
| sp|Q9V2G3|RFCL_PYRAB | Replication factor C large subunit OS=Pyrococcus abyssi (strain GE5 / Orsay) GN=rfcL PE=1 SV=3 | 540 | 647 | 1.0E-07 |
| sp|Q12TX1|RFCL_METBU | Replication factor C large subunit OS=Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M) GN=rfcL PE=3 SV=1 | 541 | 794 | 3.0E-07 |
| sp|Q8Q084|RFCL_METMA | Replication factor C large subunit OS=Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) GN=rfcL PE=3 SV=1 | 541 | 640 | 6.0E-07 |
| sp|Q5JHP1|RFCL_THEKO | Replication factor C large subunit OS=Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) GN=rfcL PE=1 SV=1 | 540 | 659 | 7.0E-07 |
| sp|O57853|RFCL_PYRHO | Replication factor C large subunit OS=Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) GN=rfcL PE=3 SV=1 | 540 | 647 | 1.0E-06 |
| sp|Q9UWR2|RFCL_PYRFU | Replication factor C large subunit OS=Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) GN=rfcL PE=1 SV=1 | 540 | 659 | 2.0E-06 |
| sp|Q46AT6|RFCL_METBF | Replication factor C large subunit OS=Methanosarcina barkeri (strain Fusaro / DSM 804) GN=rfcL PE=3 SV=1 | 541 | 640 | 4.0E-06 |
| GO Term | Description | Terminal node |
|---|---|---|
| GO:0016491 | oxidoreductase activity | Yes |
| GO:0003674 | molecular_function | No |
| GO:0003824 | catalytic activity | No |
| SignalP signal predicted | Location (based on Ymax) |
D score (significance: > 0.45) |
|---|---|---|
| No | 1 - 20 | 0.45 |
| Type of sequence | Sequence |
|---|---|
| Locus | Download genbank file of locus
The gene with 5 kb flanks (if sufficient flanking sequence is available). For use in cloning design programs. NOTE: features (genes or exons) that are only partially contained within the sequence are completely excluded. |
| Protein | >Ophun1|4757 MSGILSRLVGSQRTTQTTGLQPIEVHQVETDPDRRARCLKHLLKANHVNYAMVLDKTLAVNHSAHLLSAAYLLGA SGDQLLALFESETQHLEPWVPAPAEVVDLDWEDFFGDKRYQRAYVDFFEDKLVMDFSYDWKKEVEHFLFVGEKPL FHGLTGGLGHALVHLGYAYEMDCKEIAMEALSLACLQRNFLHKYLDDESYTRPSPLAPDSLLDLIESMSVDERFD MLPTGVRSNEVEALFDEHQEFIMDYWNAWKIEDPVTQLREAQQTVVWLLMNSTATHTYNLSFVHLLATSHALRVL LPVIPPHYHLALMREWWLLVIMIFIIKGLSWPSRLFVKEDIGSKDWAYVEKQALGSRWSKDAHYIKAKRRRRNPV EDSDDEAEQPRATLANYLISSPTRKEPPSPSKNVTAQKRPRRAATQSNGVGPSPKKAASNGRSDEKPKTADLKTL FSKQAQRTTRSATSARTNTPIDDIISDPISEEDEISDLKASSSSLVGQHARKRLKNSSSAGAVEVQSASRKFLKP TKPATIPSVDDDLRPWSERFGPRNLDELAVHKRKVSDVRRWLEAVTAGRIRQRLLVLKGAAGSGKTTTVRLLAQD MGLELLEWKNPAGSRDMLSPSTSAQFDEFLGRGGKFGMLDVEAPGTPSSSGVAAQDLSKRIMLVEEFPNTFSRTS STLASFRKSILGFLDAAARPKSQAVNPMIVVISETLLTTTSATADSLTAHRLLGPEILRHPGAVVMEFNAIAPTF LAKAMELIVQKEARKSGRRKTPGPMVLNRLGEIGDIRSAISALEFLCLKGDYEADWGAKVAFTKQKKGVRDGIGL TQSEAETLESITQREASLGIFHAVGKVVYNKRDEAAPADDTVETLPSFMAEFARPNRSQVPVDSLIDEIGTDTQT FVSALHENYILSCESTEPMDTSTSMDYVNECIEYLSLSDLLGPSRDVFFGGFGRDSSSSQQLRQDEMTFQVAVRG LLFSLPHPVKRRPTGTLKGGDAFKMFYPTSIKLWKAKEEIEGLVDVWSSRLLRGEDQLGSKNSTDGANAFRKPTT TSWTERAQRQATAANSEVSEARPPMWLGSTARREMVLDRLPYMAHLARARRSGTRDLEKMVAMRGTTTPTDEDED GDAEVDGSAVEAWATDRPSEEASPRRRRAGVRAGEVSGLMAQKLVLSDDDIEDD* |
| Coding | >Ophun1|4757 ATGTCCGGAATCCTGAGCCGGCTCGTGGGATCACAGCGTACAACGCAGACCACTGGCCTCCAGCCCATCGAGGTT CACCAGGTAGAGACCGATCCTGACCGCCGAGCTCGATGCCTCAAGCACCTCCTCAAGGCCAATCATGTCAACTAT GCCATGGTCCTGGACAAGACCCTCGCCGTCAATCACAGCGCTCATCTGCTCAGCGCCGCCTACCTCCTCGGTGCC AGCGGTGACCAGCTTCTCGCTCTCTTCGAGTCAGAGACACAACACCTCGAGCCCTGGGTCCCCGCACCGGCCGAG GTGGTCGACTTGGATTGGGAGGACTTCTTCGGCGACAAGCGCTACCAGAGGGCTTACGTTGATTTCTTCGAAGAC AAGCTGGTCATGGACTTTTCTTACGACTGGAAGAAGGAGGTCGAGCACTTTCTCTTCGTCGGCGAGAAGCCCCTC TTTCACGGCTTGACTGGTGGCCTCGGACATGCCCTCGTCCATCTGGGCTACGCTTATGAGATGGACTGTAAGGAG ATTGCCATGGAAGCTCTCAGCCTGGCCTGCCTCCAAAGGAACTTTCTGCACAAGTATCTCGACGACGAGTCTTAT ACGAGGCCGTCGCCGCTCGCGCCAGACTCTTTATTGGACCTGATCGAGAGCATGTCGGTTGACGAGAGATTCGAC ATGCTGCCTACGGGCGTCCGCTCTAATGAAGTCGAGGCCCTGTTCGATGAGCACCAAGAGTTCATCATGGACTAC TGGAACGCATGGAAGATTGAGGATCCAGTGACGCAGCTCCGAGAGGCACAACAGACAGTCGTCTGGTTGCTGATG AATTCGACGGCTACTCATACGTACAACCTCAGCTTCGTCCATTTGCTGGCAACCAGTCATGCCTTGCGAGTACTG CTGCCCGTCATTCCTCCCCATTATCACCTCGCCTTGATGCGGGAATGGTGGCTTCTGGTCATCATGATATTCATC ATCAAGGGCCTGTCGTGGCCAAGTCGCCTGTTTGTCAAAGAGGATATCGGAAGCAAAGACTGGGCCTATGTCGAG AAGCAGGCTCTCGGCTCTCGATGGTCCAAGGATGCCCACTATATCAAGGCGAAGCGCCGCAGGCGAAACCCGGTC GAGGACTCTGACGACGAGGCCGAACAGCCTCGAGCCACGCTGGCCAACTACCTGATATCGTCCCCGACAAGAAAA GAGCCGCCGAGTCCCTCAAAGAACGTCACCGCGCAGAAAAGACCTCGCAGAGCCGCGACGCAGAGCAATGGGGTC GGGCCGAGCCCCAAAAAGGCGGCCAGCAACGGACGGTCCGACGAGAAGCCCAAGACGGCCGATCTCAAGACGCTC TTCTCCAAGCAGGCTCAGAGAACGACGAGGTCGGCTACAAGCGCAAGGACGAACACGCCCATTGACGACATCATC AGCGATCCCATCTCCGAGGAGGACGAAATCTCGGATCTCAAAGCCAGCTCCTCCAGCCTGGTCGGGCAGCATGCA AGGAAACGCTTGAAGAACAGCTCCAGCGCCGGCGCGGTCGAAGTCCAGAGCGCAAGTCGGAAATTCCTGAAGCCG ACGAAGCCGGCCACCATCCCCTCCGTCGACGACGATCTGCGGCCCTGGTCGGAAAGATTCGGCCCCAGAAACCTC GACGAGCTGGCGGTGCACAAGAGAAAAGTTTCCGACGTCCGCAGGTGGCTCGAGGCCGTCACCGCTGGTCGGATA CGGCAGCGGTTGCTGGTGCTCAAGGGCGCTGCGGGCTCTGGCAAGACGACAACGGTACGGCTGCTGGCGCAAGAC ATGGGGCTGGAGCTATTGGAATGGAAGAATCCAGCAGGCTCCCGTGATATGCTTTCGCCGTCGACATCGGCACAG TTTGACGAGTTCCTGGGCCGAGGGGGAAAGTTTGGTATGCTCGACGTCGAGGCGCCTGGCACACCCAGCAGTTCA GGGGTTGCGGCTCAAGACCTATCCAAGAGGATCATGCTCGTCGAAGAGTTTCCAAACACTTTCTCTAGGACATCT TCCACTCTGGCGTCGTTCCGGAAGTCTATTCTCGGCTTTCTCGACGCTGCTGCCCGACCCAAGTCGCAAGCAGTC AATCCCATGATTGTCGTCATATCCGAGACTCTCCTGACGACAACCTCGGCAACGGCAGACAGCCTGACGGCCCAC CGGCTTCTCGGGCCTGAGATTCTGCGTCACCCAGGCGCGGTGGTGATGGAATTCAACGCCATCGCGCCCACGTTC CTGGCCAAGGCTATGGAGCTCATCGTGCAGAAAGAGGCGCGCAAGTCGGGGCGAAGGAAGACGCCGGGGCCGATG GTGCTGAATCGGCTGGGCGAGATTGGCGACATTCGCAGCGCCATCTCGGCGCTCGAGTTTCTCTGCCTCAAAGGC GACTACGAGGCCGACTGGGGAGCCAAGGTGGCGTTTACGAAGCAGAAAAAGGGCGTCCGAGATGGCATCGGCCTG ACGCAGAGCGAAGCAGAGACTCTCGAGTCGATAACACAGCGCGAGGCCAGCCTGGGCATCTTTCACGCCGTCGGC AAAGTCGTATACAACAAGCGAGACGAGGCGGCCCCAGCAGACGACACGGTGGAGACGCTGCCGTCGTTCATGGCC GAGTTTGCGCGGCCCAACAGGTCGCAAGTGCCCGTCGACAGCCTCATCGACGAGATTGGGACGGACACGCAGACG TTTGTATCGGCCCTGCACGAGAATTACATCTTGTCCTGTGAGAGCACGGAGCCGATGGACACGTCGACTTCGATG GACTACGTCAACGAGTGCATCGAGTACCTCTCCCTCAGCGACCTGCTCGGACCGTCTAGGGACGTCTTCTTTGGC GGGTTCGGGAGGGACAGCAGCAGCAGTCAGCAGCTGCGACAAGATGAGATGACGTTTCAGGTGGCCGTTCGAGGC CTGTTGTTCTCGCTGCCGCACCCTGTCAAGCGGAGACCGACGGGGACGCTCAAAGGCGGTGACGCCTTCAAGATG TTTTACCCGACGAGCATCAAGCTGTGGAAGGCAAAGGAGGAGATTGAAGGCCTCGTGGACGTGTGGTCATCACGA CTACTCAGGGGCGAGGACCAGCTGGGAAGCAAGAACTCGACCGACGGCGCCAACGCATTCCGCAAACCGACGACG ACATCGTGGACGGAGCGGGCGCAACGACAGGCTACAGCGGCGAACAGCGAGGTATCAGAGGCACGACCGCCCATG TGGCTCGGCAGCACGGCACGACGGGAGATGGTGCTGGACCGGCTGCCGTACATGGCGCACCTGGCGCGCGCCAGG AGAAGCGGCACGCGCGATCTGGAGAAGATGGTAGCTATGCGGGGAACGACGACACCAACAGACGAAGACGAAGAC GGAGACGCAGAGGTAGACGGGTCTGCGGTCGAGGCGTGGGCCACAGACAGGCCATCAGAGGAAGCCAGTCCGCGG AGACGACGTGCTGGGGTGAGGGCGGGAGAGGTCTCGGGGCTGATGGCGCAGAAGCTCGTGCTGAGTGACGATGAT ATTGAGGATGATTAG |
| Transcript | >Ophun1|4757 ATGTCCGGAATCCTGAGCCGGCTCGTGGGATCACAGCGTACAACGCAGACCACTGGCCTCCAGCCCATCGAGGTT CACCAGGTAGAGACCGATCCTGACCGCCGAGCTCGATGCCTCAAGCACCTCCTCAAGGCCAATCATGTCAACTAT GCCATGGTCCTGGACAAGACCCTCGCCGTCAATCACAGCGCTCATCTGCTCAGCGCCGCCTACCTCCTCGGTGCC AGCGGTGACCAGCTTCTCGCTCTCTTCGAGTCAGAGACACAACACCTCGAGCCCTGGGTCCCCGCACCGGCCGAG GTGGTCGACTTGGATTGGGAGGACTTCTTCGGCGACAAGCGCTACCAGAGGGCTTACGTTGATTTCTTCGAAGAC AAGCTGGTCATGGACTTTTCTTACGACTGGAAGAAGGAGGTCGAGCACTTTCTCTTCGTCGGCGAGAAGCCCCTC TTTCACGGCTTGACTGGTGGCCTCGGACATGCCCTCGTCCATCTGGGCTACGCTTATGAGATGGACTGTAAGGAG ATTGCCATGGAAGCTCTCAGCCTGGCCTGCCTCCAAAGGAACTTTCTGCACAAGTATCTCGACGACGAGTCTTAT ACGAGGCCGTCGCCGCTCGCGCCAGACTCTTTATTGGACCTGATCGAGAGCATGTCGGTTGACGAGAGATTCGAC ATGCTGCCTACGGGCGTCCGCTCTAATGAAGTCGAGGCCCTGTTCGATGAGCACCAAGAGTTCATCATGGACTAC TGGAACGCATGGAAGATTGAGGATCCAGTGACGCAGCTCCGAGAGGCACAACAGACAGTCGTCTGGTTGCTGATG AATTCGACGGCTACTCATACGTACAACCTCAGCTTCGTCCATTTGCTGGCAACCAGTCATGCCTTGCGAGTACTG CTGCCCGTCATTCCTCCCCATTATCACCTCGCCTTGATGCGGGAATGGTGGCTTCTGGTCATCATGATATTCATC ATCAAGGGCCTGTCGTGGCCAAGTCGCCTGTTTGTCAAAGAGGATATCGGAAGCAAAGACTGGGCCTATGTCGAG AAGCAGGCTCTCGGCTCTCGATGGTCCAAGGATGCCCACTATATCAAGGCGAAGCGCCGCAGGCGAAACCCGGTC GAGGACTCTGACGACGAGGCCGAACAGCCTCGAGCCACGCTGGCCAACTACCTGATATCGTCCCCGACAAGAAAA GAGCCGCCGAGTCCCTCAAAGAACGTCACCGCGCAGAAAAGACCTCGCAGAGCCGCGACGCAGAGCAATGGGGTC GGGCCGAGCCCCAAAAAGGCGGCCAGCAACGGACGGTCCGACGAGAAGCCCAAGACGGCCGATCTCAAGACGCTC TTCTCCAAGCAGGCTCAGAGAACGACGAGGTCGGCTACAAGCGCAAGGACGAACACGCCCATTGACGACATCATC AGCGATCCCATCTCCGAGGAGGACGAAATCTCGGATCTCAAAGCCAGCTCCTCCAGCCTGGTCGGGCAGCATGCA AGGAAACGCTTGAAGAACAGCTCCAGCGCCGGCGCGGTCGAAGTCCAGAGCGCAAGTCGGAAATTCCTGAAGCCG ACGAAGCCGGCCACCATCCCCTCCGTCGACGACGATCTGCGGCCCTGGTCGGAAAGATTCGGCCCCAGAAACCTC GACGAGCTGGCGGTGCACAAGAGAAAAGTTTCCGACGTCCGCAGGTGGCTCGAGGCCGTCACCGCTGGTCGGATA CGGCAGCGGTTGCTGGTGCTCAAGGGCGCTGCGGGCTCTGGCAAGACGACAACGGTACGGCTGCTGGCGCAAGAC ATGGGGCTGGAGCTATTGGAATGGAAGAATCCAGCAGGCTCCCGTGATATGCTTTCGCCGTCGACATCGGCACAG TTTGACGAGTTCCTGGGCCGAGGGGGAAAGTTTGGTATGCTCGACGTCGAGGCGCCTGGCACACCCAGCAGTTCA GGGGTTGCGGCTCAAGACCTATCCAAGAGGATCATGCTCGTCGAAGAGTTTCCAAACACTTTCTCTAGGACATCT TCCACTCTGGCGTCGTTCCGGAAGTCTATTCTCGGCTTTCTCGACGCTGCTGCCCGACCCAAGTCGCAAGCAGTC AATCCCATGATTGTCGTCATATCCGAGACTCTCCTGACGACAACCTCGGCAACGGCAGACAGCCTGACGGCCCAC CGGCTTCTCGGGCCTGAGATTCTGCGTCACCCAGGCGCGGTGGTGATGGAATTCAACGCCATCGCGCCCACGTTC CTGGCCAAGGCTATGGAGCTCATCGTGCAGAAAGAGGCGCGCAAGTCGGGGCGAAGGAAGACGCCGGGGCCGATG GTGCTGAATCGGCTGGGCGAGATTGGCGACATTCGCAGCGCCATCTCGGCGCTCGAGTTTCTCTGCCTCAAAGGC GACTACGAGGCCGACTGGGGAGCCAAGGTGGCGTTTACGAAGCAGAAAAAGGGCGTCCGAGATGGCATCGGCCTG ACGCAGAGCGAAGCAGAGACTCTCGAGTCGATAACACAGCGCGAGGCCAGCCTGGGCATCTTTCACGCCGTCGGC AAAGTCGTATACAACAAGCGAGACGAGGCGGCCCCAGCAGACGACACGGTGGAGACGCTGCCGTCGTTCATGGCC GAGTTTGCGCGGCCCAACAGGTCGCAAGTGCCCGTCGACAGCCTCATCGACGAGATTGGGACGGACACGCAGACG TTTGTATCGGCCCTGCACGAGAATTACATCTTGTCCTGTGAGAGCACGGAGCCGATGGACACGTCGACTTCGATG GACTACGTCAACGAGTGCATCGAGTACCTCTCCCTCAGCGACCTGCTCGGACCGTCTAGGGACGTCTTCTTTGGC GGGTTCGGGAGGGACAGCAGCAGCAGTCAGCAGCTGCGACAAGATGAGATGACGTTTCAGGTGGCCGTTCGAGGC CTGTTGTTCTCGCTGCCGCACCCTGTCAAGCGGAGACCGACGGGGACGCTCAAAGGCGGTGACGCCTTCAAGATG TTTTACCCGACGAGCATCAAGCTGTGGAAGGCAAAGGAGGAGATTGAAGGCCTCGTGGACGTGTGGTCATCACGA CTACTCAGGGGCGAGGACCAGCTGGGAAGCAAGAACTCGACCGACGGCGCCAACGCATTCCGCAAACCGACGACG ACATCGTGGACGGAGCGGGCGCAACGACAGGCTACAGCGGCGAACAGCGAGGTATCAGAGGCACGACCGCCCATG TGGCTCGGCAGCACGGCACGACGGGAGATGGTGCTGGACCGGCTGCCGTACATGGCGCACCTGGCGCGCGCCAGG AGAAGCGGCACGCGCGATCTGGAGAAGATGGTAGCTATGCGGGGAACGACGACACCAACAGACGAAGACGAAGAC GGAGACGCAGAGGTAGACGGGTCTGCGGTCGAGGCGTGGGCCACAGACAGGCCATCAGAGGAAGCCAGTCCGCGG AGACGACGTGCTGGGGTGAGGGCGGGAGAGGTCTCGGGGCTGATGGCGCAGAAGCTCGTGCTGAGTGACGATGAT ATTGAGGATGATTAG |
| Gene | >Ophun1|4757 ATGTCCGGAATCCTGAGCCGGCTCGTGGGATCACAGCGTACAACGCAGACCACTGGCCTCCAGCCCATCGAGGTT CACCAGGTAGAGACCGATCCTGACCGCCGAGCTCGATGCCTCAAGCACCTCCTCAAGGCCAATCATGTCAACTAT GCCATGGTCCTGGACAAGACCCTCGCCGTCAATCACAGCGCTCATCTGCTCAGCGCCGCCTACCTCCTCGGTGCC AGCGGTGACCAGCTTCTCGCTCTCTTCGAGTCAGAGACACAACACCTCGAGCCCTGGGTCCCCGCACCGGCCGAG GTGGTCGACTTGGATTGGGAGGACTTCTTCGGCGACAAGCGCTACCAGAGGGCTTACGTTGATTTCTTCGAAGAC AAGCTGGTCATGGACTTTTCTTACGACTGGAAGAAGGAGGTCGAGCACTTTCTCTTCGTCGGCGAGAAGCCCCTC TTTCACGGCTTGACTGGTGGCCGTATGTCTGACCCCGTAGAGCTGGTTATCGAGCTGACGCGTCGCTAGTCGGAC ATGCCCTCGTCCATCTGGGCTACGCTTATGAGATGGACTGTAAGGAGATTGCCATGGAAGCTCTCAGCCTGGCCT GCCTCCAAAGGAACTTTCTGCACAAGTATCTCGACGACGAGTCTTATACGAGGCCGTCGCCGCTCGCGCCAGACT CTTTATTGGACCTGATCGAGAGCATGTCGGTTGACGAGAGATTCGACATGCTGCCTACGGGCGTCCGCTCTAATG AAGTCGAGGCCCTGTTCGATGAGCACCAAGAGTTCATCATGGACTACTGGAACGCATGGAAGATTGAGGATCCAG TGACGCAGCTCCGAGAGGCACAACAGACAGTCGTCTGGTTGCTGATGAATTCGACGGCTACTCATACGTACAACC TCAGCTTCGTCCATTTGCTGGCAACCAGTCATGCCTTGCGAGTACTGCTGCCCGTCATTCCTCCCCATTATCACC TCGCCTTGATGCGGGAATGGTGGCTTCTGGTCATCATGATATTCATCATCAAGGGCCTGTCGTGGCCAAGTCGCC TGTTTGTCAAAGAGGATATCGGAAGCAAAGACTGGGCCTATGTCGAGAAGCAGGCTCTCGGCTCTCGATGGTCCA AGGATGCCCACTATATCAAGGGTGAGAGTCCCGCGACCCCGGCAGGTAACGTGCTGACGGACGCAGCGATTCGCG CGATGAGGGATGCTGCAAAGACGTGGGGGGATGCAGATGATCAATTTCTTCAGAGCGCAGTAGCATTTGTCGATG GCTTCAAAGGCTGGACGTATTGAAATGGACGTTGAGTCGATTCTTATCTGTAGAACGGCTCCTGCTAAGGTGGCT CACTGTGTCATCTAAGAACCGCCATGCACCGTGTACAGTCAGCTGCGAGCGCCTTGTGGGTTGCTCCGGCGGACG ACTATTCCTGGCCCTGCTGCCACGAGGCTACCAACGACTACAGCCTACGAGTGCCTACAGGACAATTTTCAGTCT ACGGAGAGGCTACTTGTTGACTACAGACCGATGTCTGCGTGAAAGACCCTTCGCCACTCCAATGGCCCCGCCAGC GAAGCGCCGCAGGCGAAACCCGGTCGAGGACTCTGACGACGAGGCCGAACAGCCTCGAGCCACGCTGGCCAACTA CCTGATATCGTCCCCGACAAGAAAAGAGCCGCCGAGTCCCTCAAAGAACGTCACCGCGCAGAAAAGACCTCGCAG AGCCGCGACGCAGAGCAATGGGGTCGGGCCGAGCCCCAAAAAGGCGGCCAGCAACGGACGGTCCGACGAGAAGCC CAAGACGGCCGATCTCAAGACGCTCTTCTCCAAGCAGGCTCAGAGAACGACGAGGTCGGCTACAAGCGCAAGGAC GAACACGCCCATTGACGACATCATCAGCGATCCCATCTCCGAGGAGGACGAAATCTCGGATCTCAAAGCCAGCTC CTCCAGCCTGGTCGGGCAGCATGCAAGGAAACGCTTGAAGAACAGCTCCAGCGCCGGCGCGGTCGAAGTCCAGAG CGCAAGTCGGAAATTCCTGAAGCCGACGAAGCCGGCCACCATCCCCTCCGTCGACGACGATCTGCGGCCCTGGTC GGAAAGATTCGGCCCCAGAAACCTCGACGAGCTGGCGGTGCACAAGAGAAAAGTTTCCGACGTCCGCAGGTGGCT CGAGGCCGTCACCGCTGGTCGGATACGGCAGCGGTTGCTGGTGCTCAAGGGCGCTGCGGGCTCTGGCAAGACGAC AACGGTACGGCTGCTGGCGCAAGACATGGGGCTGGAGCTATTGGAATGGAAGAATCCAGCAGGCTCCCGTGATAT GCTTTCGCCGTCGACATCGGCACAGTTTGACGAGTTCCTGGGCCGAGGGGGAAAGTTTGGTATGCTCGACGTCGA GGCGCCTGGCACACCCAGCAGTTCAGGGGTTGCGGCTCAAGACCTATCCAAGAGGATCATGCTCGTCGAAGAGTT TCCAAACACTTTCTCTAGGACATCTTCCACTCTGGCGTCGTTCCGGAAGTCTATTCTCGGCTTTCTCGACGCTGC TGCCCGACCCAAGTCGCAAGCAGTCAATCCCATGATTGTCGTCATATCCGAGACTCTCCTGACGACAACCTCGGC AACGGCAGACAGCCTGACGGCCCACCGGCTTCTCGGGCCTGAGATTCTGCGTCACCCAGGCGCGGTGGTGATGGA ATTCAACGCCATCGCGCCCACGTTCCTGGCCAAGGCTATGGAGCTCATCGTGCAGAAAGAGGCGCGCAAGTCGGG GCGAAGGAAGACGCCGGGGCCGATGGTGCTGAATCGGCTGGGCGAGATTGGCGACATTCGCAGCGCCATCTCGGC GCTCGAGTTTCTCTGCCTCAAAGGCGACTACGAGGCCGACTGGGGAGCCAAGGTGGCGTTTACGAAGCAGAAAAA GGGCGTCCGAGATGGCATCGGCCTGACGCAGAGCGAAGCAGAGACTCTCGAGTCGATAACACAGCGCGAGGCCAG CCTGGGCATCTTTCACGCCGTCGGCAAAGTCGTATACAACAAGCGAGACGAGGCGGCCCCAGCAGACGACACGGT GGAGACGCTGCCGTCGTTCATGGCCGAGTTTGCGCGGCCCAACAGGTCGCAAGTGCCCGTCGACAGCCTCATCGA CGAGATTGGGACGGACACGCAGACGTTTGTATCGGCCCTGCACGAGAATTACATCTTGTCCTGTGAGAGCACGGA GCCGATGGACACGTCGACTTCGATGGACTACGTCAACGAGTGCATCGAGTACCTCTCCCTCAGCGACCTGCTCGG ACCGTCTAGGGACGTCTTCTTTGGCGGGTTCGGGAGGGACAGCAGCAGCAGTCAGCAGCTGCGACAAGATGAGAT GACGTTTCAGGTGGCCGTTCGAGGCCTGTTGTTCTCGCTGCCGCACCCTGTCAAGCGGAGACCGACGGGGACGCT CAAAGGCGGTGACGCCTTCAAGATGTTTTACCCGACGAGCATCAAGCTGTGGAAGGCAAAGGAGGAGATTGAAGG CCTCGTGGACGTGTGGTCATCACGACTACTCAGGGGCGAGGACCAGCTGGGAAGCAAGAACTCGACCGACGGCGC CAACGCATTCCGCAAACCGACGACGACATCGTGGACGGAGCGGGCGCAACGACAGGCTACAGCGGCGAACAGCGA GGTATCAGAGGCACGACCGCCCATGTGGCTCGGCAGCACGGCACGACGGGAGATGGTGCTGGACCGGCTGCCGTA CATGGCGCACCTGGCGCGCGCCAGGAGAAGCGGCACGCGCGATCTGGAGAAGATGGTAGCTATGCGGGGAACGAC GACACCAACAGACGAAGACGAAGACGGAGACGCAGAGGTAGACGGGTCTGCGGTCGAGGCGTGGGCCACAGACAG GCCATCAGAGGAAGCCAGTCCGCGGAGACGACGTGCTGGGGTGAGGGCGGGAGAGGTCTCGGGGCTGATGGCGCA GAAGCTCGTGCTGAGTGACGATGATATTGAGGATGATTAG |