Fungal Genomics

at Utrecht University

General Properties

Protein IDOphio5|6220
Gene name
Locationscaffold_533:6889..7687
Strand+
Gene length (bp)798
Transcript length (bp)798
Coding sequence length (bp)795
Protein length (aa) 265

Overview

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PFAM Domains

PFAM Domain ID Short name Long name E-value Start End
PF04140 ICMT Isoprenylcysteine carboxyl methyltransferase (ICMT) family 9.4E-29 151 244
PF04191 PEMT Phospholipid methyltransferase 9.3E-11 147 247

Swissprot hits

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Swissprot ID Swissprot Description Start End E-value
sp|Q9WVM4|ICMT_RAT Protein-S-isoprenylcysteine O-methyltransferase (Fragment) OS=Rattus norvegicus GN=Icmt PE=1 SV=1 42 265 3.0E-50
sp|Q9EQK7|ICMT_MOUSE Protein-S-isoprenylcysteine O-methyltransferase OS=Mus musculus GN=Icmt PE=2 SV=2 42 265 4.0E-50
sp|O60725|ICMT_HUMAN Protein-S-isoprenylcysteine O-methyltransferase OS=Homo sapiens GN=ICMT PE=1 SV=1 42 265 7.0E-49
sp|O12947|ICMT_XENLA Protein-S-isoprenylcysteine O-methyltransferase OS=Xenopus laevis GN=icmt PE=2 SV=1 36 265 8.0E-49
sp|P32584|STE14_YEAST Protein-S-isoprenylcysteine O-methyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=STE14 PE=1 SV=1 77 264 4.0E-45
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Swissprot ID Swissprot Description Start End E-value
sp|Q9WVM4|ICMT_RAT Protein-S-isoprenylcysteine O-methyltransferase (Fragment) OS=Rattus norvegicus GN=Icmt PE=1 SV=1 42 265 3.0E-50
sp|Q9EQK7|ICMT_MOUSE Protein-S-isoprenylcysteine O-methyltransferase OS=Mus musculus GN=Icmt PE=2 SV=2 42 265 4.0E-50
sp|O60725|ICMT_HUMAN Protein-S-isoprenylcysteine O-methyltransferase OS=Homo sapiens GN=ICMT PE=1 SV=1 42 265 7.0E-49
sp|O12947|ICMT_XENLA Protein-S-isoprenylcysteine O-methyltransferase OS=Xenopus laevis GN=icmt PE=2 SV=1 36 265 8.0E-49
sp|P32584|STE14_YEAST Protein-S-isoprenylcysteine O-methyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=STE14 PE=1 SV=1 77 264 4.0E-45
sp|P87014|MAM4_SCHPO Protein-S-isoprenylcysteine O-methyltransferase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=mam4 PE=3 SV=1 77 265 9.0E-40
sp|Q558K8|ICMT_DICDI Protein-S-isoprenylcysteine O-methyltransferase OS=Dictyostelium discoideum GN=icmt-1 PE=2 SV=2 64 264 1.0E-31
sp|Q93W54|ICMTB_ARATH Protein-S-isoprenylcysteine O-methyltransferase B OS=Arabidopsis thaliana GN=ICMTB PE=1 SV=1 99 262 7.0E-27
sp|Q7XSR9|ICMT_ORYSJ Probable protein-S-isoprenylcysteine O-methyltransferase OS=Oryza sativa subsp. japonica GN=ICMT PE=3 SV=2 77 265 5.0E-26
sp|A2XX73|ICMT_ORYSI Probable protein-S-isoprenylcysteine O-methyltransferase OS=Oryza sativa subsp. indica GN=ICMT PE=3 SV=2 77 265 5.0E-26
sp|Q9FMW9|ICMTA_ARATH Protein-S-isoprenylcysteine O-methyltransferase A OS=Arabidopsis thaliana GN=ICMTA PE=1 SV=1 67 262 2.0E-23
sp|P29940|YCB7_PSEDE PEMT/PEM2 methyltransferase family protein OS=Pseudomonas denitrificans PE=3 SV=1 139 258 2.0E-08
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GO

GO Term Description Terminal node
GO:0006481 C-terminal protein methylation Yes
GO:0004671 protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity Yes
GO:0016021 integral component of membrane Yes
GO:0031224 intrinsic component of membrane No
GO:0016740 transferase activity No
GO:0044260 cellular macromolecule metabolic process No
GO:0003674 molecular_function No
GO:0044237 cellular metabolic process No
GO:0008152 metabolic process No
GO:0043412 macromolecule modification No
GO:0043414 macromolecule methylation No
GO:0110165 cellular anatomical entity No
GO:0044238 primary metabolic process No
GO:0018410 C-terminal protein amino acid modification No
GO:1901564 organonitrogen compound metabolic process No
GO:0016741 transferase activity, transferring one-carbon groups No
GO:0008171 O-methyltransferase activity No
GO:0008150 biological_process No
GO:0043170 macromolecule metabolic process No
GO:0005575 cellular_component No
GO:0032259 methylation No
GO:0008168 methyltransferase activity No
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity No
GO:0003824 catalytic activity No
GO:0006807 nitrogen compound metabolic process No
GO:0051998 protein carboxyl O-methyltransferase activity No
GO:0006479 protein methylation No
GO:0036211 protein modification process No
GO:0008276 protein methyltransferase activity No
GO:0010340 carboxyl-O-methyltransferase activity No
GO:0019538 protein metabolic process No
GO:0003880 protein C-terminal carboxyl O-methyltransferase activity No
GO:0009987 cellular process No
GO:0008213 protein alkylation No
GO:0140096 catalytic activity, acting on a protein No
GO:0071704 organic substance metabolic process No
GO:0043687 post-translational protein modification No

Deeploc

[Help with interpreting the results of Deeploc 2.0]
Localizations Signals Cytoplasm Nucleus Extracellular Cell membrane Mitochondrion Plastid Endoplasmic reticulum Lysosome vacuole Golgi apparatus Peroxisome
Endoplasmic reticulum Signal peptide|Transmembrane domain 0.0506 0.2396 0.0127 0.0541 0.117 0.0417 0.8221 0.2232 0.3399 0.0316

SignalP

(None)

Transmembrane Domains

Domain # Start End Length
1 42 64 22
2 71 93 22
3 113 132 19
4 137 159 22
5 209 231 22

Transcription Factor Class

(None)

CAZymes

(None)

Secondary Metabolism

(None)

Expression data

Analysis 1: Expression analysis during behavioral modification. Published in De Bekker et al., 2017.

Expression values

Label Description Expression (RPKM) Confidence interval (low) Confidence interval (high)
SC16a Pure fungal culture 6.81 1.68 11.95
CcL In ants, during behavior modification 6.18 1.28 11.07
CcD In ants, recently dead 7.79 1.88 13.70

Differential expression

Label1 Label2 Q-value Significant difference
SC16a CcL 0.839299 no
SC16a CcD 0.775344 no
CcL CcD 0.602589 no

Orthologs

Orthofinder run ID4
Orthogroup4192
Change Orthofinder run
Species Protein ID
Ophiocordyceps australis 1348a (Ghana) OphauG2|6547
Ophiocordyceps australis map64 (Brazil) OphauB2|4131
Ophiocordyceps camponoti-floridani Ophcf2|07119
Ophiocordyceps camponoti-rufipedis Ophun1|3667
Ophiocordyceps kimflemingae Ophio5|6220 (this protein)
Ophiocordyceps subramaniannii Hirsu2|8514

Sequences

Type of sequenceSequence
Locus Download genbank file of locus Download genbank file of locus (reverse complement)
The gene with 5 kb flanks (if sufficient flanking sequence is available). For use in cloning design programs. NOTE: features (genes or exons) that are only partially contained within the sequence are completely excluded.
Protein >Ophio5|6220
MDHEAPPLQRLSNPPRPCSPASSEDDDLKPFYPGQPSSLSGIAIRAFSLGIAFATGALLTASILFLTDSPLWRVP
FFLVPLSAFHFLEFWTTAEANTPRAGIDSFLLTANWPSYAIAHSAAFVEAALVGFFFPRRQWAPFHSGPLLVALG
LLLVVVGQAVRSCAMLQAGLSFNHRVQTKKAGSHTLVTTGIYALLRHPSYFGFFYWSLGTQLVLGNVVCFAVYAA
VLWNFFRARIGMEESKLIEFFQDDYVQYRRRVRTMLPAIP
Coding >Ophio5|6220
ATGGACCATGAGGCGCCGCCTCTCCAGCGGCTTTCCAACCCCCCTCGCCCCTGTTCACCCGCCTCCTCCGAAGAC
GATGACCTCAAGCCCTTCTACCCAGGCCAGCCCAGCTCCCTCTCCGGCATCGCCATTCGCGCCTTTAGCCTCGGG
ATCGCCTTCGCTACGGGCGCCCTACTGACCGCCTCCATCCTCTTTCTCACCGATAGCCCTCTCTGGCGCGTCCCC
TTCTTCCTCGTCCCCCTATCCGCCTTTCACTTCCTAGAGTTCTGGACCACCGCCGAGGCAAACACTCCCCGTGCC
GGCATCGACAGCTTCCTCCTAACGGCCAACTGGCCGTCGTACGCCATCGCACACTCCGCTGCCTTCGTCGAGGCC
GCACTCGTCGGCTTCTTCTTCCCCCGCCGTCAATGGGCGCCTTTCCACTCGGGCCCTCTTCTCGTCGCTCTCGGT
CTCCTACTTGTCGTCGTCGGCCAGGCTGTCCGCTCTTGTGCCATGCTTCAGGCCGGCCTTAGCTTCAATCACCGC
GTGCAGACGAAAAAGGCTGGCTCGCATACTCTCGTCACCACCGGCATTTACGCCCTCCTGCGCCATCCCAGCTAC
TTTGGCTTTTTCTACTGGAGCCTGGGCACCCAGCTTGTGCTCGGCAACGTCGTCTGTTTCGCCGTCTACGCAGCT
GTGCTGTGGAACTTTTTCCGGGCCCGAATTGGCATGGAAGAGTCCAAGCTCATTGAGTTCTTTCAGGACGACTAT
GTCCAGTACCGGCGCAGGGTCAGGACCATGCTACCCGCCATACCA
Transcript >Ophio5|6220
ATGGACCATGAGGCGCCGCCTCTCCAGCGGCTTTCCAACCCCCCTCGCCCCTGTTCACCCGCCTCCTCCGAAGAC
GATGACCTCAAGCCCTTCTACCCAGGCCAGCCCAGCTCCCTCTCCGGCATCGCCATTCGCGCCTTTAGCCTCGGG
ATCGCCTTCGCTACGGGCGCCCTACTGACCGCCTCCATCCTCTTTCTCACCGATAGCCCTCTCTGGCGCGTCCCC
TTCTTCCTCGTCCCCCTATCCGCCTTTCACTTCCTAGAGTTCTGGACCACCGCCGAGGCAAACACTCCCCGTGCC
GGCATCGACAGCTTCCTCCTAACGGCCAACTGGCCGTCGTACGCCATCGCACACTCCGCTGCCTTCGTCGAGGCC
GCACTCGTCGGCTTCTTCTTCCCCCGCCGTCAATGGGCGCCTTTCCACTCGGGCCCTCTTCTCGTCGCTCTCGGT
CTCCTACTTGTCGTCGTCGGCCAGGCTGTCCGCTCTTGTGCCATGCTTCAGGCCGGCCTTAGCTTCAATCACCGC
GTGCAGACGAAAAAGGCTGGCTCGCATACTCTCGTCACCACCGGCATTTACGCCCTCCTGCGCCATCCCAGCTAC
TTTGGCTTTTTCTACTGGAGCCTGGGCACCCAGCTTGTGCTCGGCAACGTCGTCTGTTTCGCCGTCTACGCAGCT
GTGCTGTGGAACTTTTTCCGGGCCCGAATTGGCATGGAAGAGTCCAAGCTCATTGAGTTCTTTCAGGACGACTAT
GTCCAGTACCGGCGCAGGGTCAGGACCATGCTACCCGCCATACCATGA
Gene >Ophio5|6220
ATGGACCATGAGGCGCCGCCTCTCCAGCGGCTTTCCAACCCCCCTCGCCCCTGTTCACCCGCCTCCTCCGAAGAC
GATGACCTCAAGCCCTTCTACCCAGGCCAGCCCAGCTCCCTCTCCGGCATCGCCATTCGCGCCTTTAGCCTCGGG
ATCGCCTTCGCTACGGGCGCCCTACTGACCGCCTCCATCCTCTTTCTCACCGATAGCCCTCTCTGGCGCGTCCCC
TTCTTCCTCGTCCCCCTATCCGCCTTTCACTTCCTAGAGTTCTGGACCACCGCCGAGGCAAACACTCCCCGTGCC
GGCATCGACAGCTTCCTCCTAACGGCCAACTGGCCGTCGTACGCCATCGCACACTCCGCTGCCTTCGTCGAGGCC
GCACTCGTCGGCTTCTTCTTCCCCCGCCGTCAATGGGCGCCTTTCCACTCGGGCCCTCTTCTCGTCGCTCTCGGT
CTCCTACTTGTCGTCGTCGGCCAGGCTGTCCGCTCTTGTGCCATGCTTCAGGCCGGCCTTAGCTTCAATCACCGC
GTGCAGACGAAAAAGGCTGGCTCGCATACTCTCGTCACCACCGGCATTTACGCCCTCCTGCGCCATCCCAGCTAC
TTTGGCTTTTTCTACTGGAGCCTGGGCACCCAGCTTGTGCTCGGCAACGTCGTCTGTTTCGCCGTCTACGCAGCT
GTGCTGTGGAACTTTTTCCGGGCCCGAATTGGCATGGAAGAGTCCAAGCTCATTGAGTTCTTTCAGGACGACTAT
GTCCAGTACCGGCGCAGGGTCAGGACCATGCTACCCGCCATACCATGA

© 2023 - Robin Ohm - Utrecht University - The Netherlands

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