Fungal Genomics

Agaricus bisporus var bisporus H39 Agaricus bisporus var bisporus H97 Agaricus bisporus var burnettii H119p4 Aspergillus niger CBS 112.32 Aspergillus niger CBS 113.50 Aspergillus niger CBS 115988 Aspergillus niger CBS 115989 Aspergillus niger CBS 118.52 Aspergillus niger CBS 124.48 Aspergillus niger CBS 131.52 Aspergillus niger CBS 133816 Aspergillus niger CBS 147320 Aspergillus niger CBS 147321 Aspergillus niger CBS 147322 Aspergillus niger CBS 147323 Aspergillus niger CBS 147324 Aspergillus niger CBS 147343 Aspergillus niger CBS 147344 Aspergillus niger CBS 147345 Aspergillus niger CBS 147346 Aspergillus niger CBS 147347 Aspergillus niger CBS 147352 Aspergillus niger CBS 147353 Aspergillus niger CBS 147371 Aspergillus niger CBS 147482 Aspergillus niger CBS 630.78 Aspergillus niger CBS 769.97 Niveomyces coronatus CBS 149186 Ophiocordyceps australis 1348a (Ghana) Ophiocordyceps australis map64 (Brazil) Ophiocordyceps camponoti-floridani Ophiocordyceps camponoti-rufipedis Ophiocordyceps kimflemingae Ophiocordyceps subramaniannii Penicillium roqueforti DTO002I6 Penicillium roqueforti DTO003C3 Penicillium roqueforti DTO003H1 (CBS 147308) Penicillium roqueforti DTO006G1 Penicillium roqueforti DTO006G7 Penicillium roqueforti DTO012A1 Penicillium roqueforti DTO012A2 (CBS 147309) Penicillium roqueforti DTO012A6 (CBS 147310) Penicillium roqueforti DTO012A7 Penicillium roqueforti DTO012A8 Penicillium roqueforti DTO012A9 Penicillium roqueforti DTO013E5 Penicillium roqueforti DTO013F2 Penicillium roqueforti DTO013F5 (CBS 147311) Penicillium roqueforti DTO027I6 Penicillium roqueforti DTO032C6 Penicillium roqueforti DTO039G3 Penicillium roqueforti DTO046C5 Penicillium roqueforti DTO070G2 (CBS 147317) Penicillium roqueforti DTO081F9 (CBS 147318) Penicillium roqueforti DTO101D6 (CBS 147325) Penicillium roqueforti DTO102I9 (CBS 147326) Penicillium roqueforti DTO126G2 (CBS 147330) Penicillium roqueforti DTO127F7 (CBS 147331) Penicillium roqueforti DTO127F9 (CBS 147332) Penicillium roqueforti DTO130C1 (CBS 147333) Penicillium roqueforti DTO163C3 (CBS 147337) Penicillium roqueforti DTO163F5 (CBS 147338) Penicillium roqueforti DTO163G4 (CBS 147339) Penicillium roqueforti DTO265D5 (CBS 147372) Penicillium roqueforti DTO369A1 (CBS 147354) Penicillium roqueforti DTO375B1 (CBS 147355) Penicillium roqueforti DTO377G2 (LCP 96.3914a) Penicillium roqueforti LCP96 04111 Rhodonia placenta FPRL280 Torrubiellomyces zombiae CBS 149187

General Properties

Protein ID	Ophio5|5467
Gene name
Location	scaffold_448:7138..10520
Strand	-
Gene length (bp)	3382
Transcript length (bp)	3060
Coding sequence length (bp)	3057
Protein length (aa)	1019

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PFAM Domains

PFAM Domain ID	Short name	Long name	E-value	Start	End
PF10337	ArAE_2_N	Putative ER transporter, 6TM, N-terminal	8.8E-06	131	204
PF13515	FUSC_2	Fusaric acid resistance protein-like	8.4E-08	669	790

Swissprot hits

Swissprot ID	Swissprot Description	Start	End	E-value
sp|Q07660|BRE4_YEAST	Protein BRE4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=BRE4 PE=1 SV=1	37	960	3.0E-93
sp|Q75E41|BRE4_ASHGO	Protein BRE4 OS=Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) GN=BRE4 PE=3 SV=2	31	1019	7.0E-75
sp|P53120|YGO0_YEAST	Uncharacterized membrane protein YGL140C OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YGL140C PE=1 SV=1	643	963	5.0E-15
sp|Q10495|YDG8_SCHPO	Uncharacterized protein C26F1.08c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC26F1.08c PE=4 SV=1	625	974	3.0E-11
sp|P53120|YGO0_YEAST	Uncharacterized membrane protein YGL140C OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YGL140C PE=1 SV=1	132	317	1.0E-06

GO

(None)

SignalP

[Help with interpreting these statistics]

SignalP signal predicted	Location (based on Ymax)	D score (significance: > 0.45)
No	1 - 12	0.45

Transmembrane Domains

Domain #	Start	End	Length
1	130	152	22
2	182	204	22
3	234	256	22
4	271	290	19
5	695	717	22
6	722	739	17
7	746	763	17
8	773	795	22
9	807	829	22

Transcription Factor Class

(None)

Expression data

Analysis 1: Expression analysis during behavioral modification. Published in De Bekker et al., 2017.

Expression values

Label	Description	Expression (RPKM)	Confidence interval (low)	Confidence interval (high)
SC16a	Pure fungal culture	19.66	10.54	28.78
CcL	In ants, during behavior modification	31.37	16.82	45.93
CcD	In ants, recently dead	28.56	15.64	41.48

Differential expression

Label1	Label2	Q-value	Significant difference
SC16a	CcL	0.034007	yes
SC16a	CcD	0.095360	no
CcL	CcD	0.720786	no

Sequences

Type of sequence	Sequence
Locus	Download genbank file of locus The gene with 5 kb flanks (if sufficient flanking sequence is available). For use in cloning design programs. NOTE: features (genes or exons) that are only partially contained within the sequence are completely excluded.
Protein	>Ophio5|5467 MPHQPPDVRRRRQRHVDMRPTLDPDAFLEPVSPPPTSRRSSTHSLAQLDHMVSDKIDTETYGVSELRDGFFDAMF LRPSPSFAADLLQDSADTLPAGFEKASPLTLRCFFPRQWRALVSVVKRVTTTRAGIRLLKSLVAFFVAYVLCLVP VIRDWLGRYYYFTAVSVIVNHPARSLGSQLDGAALTVVGAACGLGWGALGLLLSKSTLAARAGYGGVLAVWMALF MTSISLTRAFFIRFYQAILAAGLAVIFATLAETGSRQVDWAKLRDYGFSWLFGQAIAMVINCVVFPDAGARDLAT TFHAAFDVMLETLDASICRDRRLRRRLTRTFVDLSQACRDMKIDITVTRFRPDDVGDLRNLMQAVIRALLTLKAD TYLFKHSPSEIDVTITVDEPILDVTTGTAAASPGHRNLSRRAIEELGDQTKHMLSCMSECVRSCDAALMDLSGHR RNLGPAPDVSSDVLPAHRKLRRAKAAYDVVEASLIESEEHLAESSIQDGDVVQLFVFARHVREAASAMEQLVDKV QAMRLALGWPRPHLPSYPFWKALHRTNAQTRHDRGGVTAGSYHVTFEEIGRLLDKMKSSDHEPVSREEVGDGPGI CLETLDSHTSLDAGVGPSSTAKTSRLRYRIWRVLKRLQGFESRYAFKVCLVTTLLSIPAYLDRDRGWWEKYECWW AVSISWLAMHPRVGGNVQDLFIRALMAVLGAAWSAAAYAAGNGNPYVMAAFAAVYMTPMLFRFTQSSHPRSGLIG CLSFTVISLRLQVESEGTSPTLLAVYSGVAFLIGATVPIVVNWVLWPFVARHELRRALSSMMFFMSVIYRSVVAR YVYFYEGKEPTPEDVQRSEMLEGRLREGFVRIRQLLVLTQKEIRLRAPFDPLPYSALADSCERFFDYLVAVRQSA LFYNPDYIRDNPQAAEQLLSYRRDAVAAILGNLYILAGALRSKRKVPRYLPNAAAARRRLLIKNAEVDEEMSRRA GASDAEWHKRWSDIYRYSYNESLVGCVAQLEELEKLTKLIVGEQ
Coding	>Ophio5|5467 ATGCCCCATCAGCCTCCAGACGTCCGTCGGCGGCGCCAGCGACATGTTGACATGCGGCCGACGCTCGACCCCGAC GCCTTCCTTGAGCCCGTCTCCCCTCCTCCGACCAGCCGTCGGAGTTCTACCCACAGCCTCGCCCAGCTCGATCAC ATGGTCTCCGACAAGATAGACACGGAGACGTATGGCGTGTCGGAGCTTCGAGACGGCTTCTTCGACGCCATGTTT CTCAGACCGTCCCCCTCGTTCGCTGCCGACCTTTTGCAGGATTCCGCCGACACGCTTCCCGCCGGCTTTGAAAAG GCCTCGCCTTTGACTCTACGCTGCTTCTTTCCCAGGCAGTGGCGAGCCTTGGTGTCCGTCGTGAAGCGCGTCACA ACCACTCGCGCCGGCATCCGACTCCTCAAATCCTTGGTCGCTTTCTTCGTCGCCTACGTCTTGTGTCTCGTGCCT GTCATCCGCGACTGGCTCGGCCGCTATTACTACTTCACCGCCGTATCCGTCATCGTCAACCACCCGGCCAGATCC TTGGGTTCCCAGCTCGACGGCGCGGCTCTCACTGTCGTGGGAGCCGCCTGCGGCTTGGGTTGGGGTGCGCTCGGT CTACTGCTGTCCAAGTCTACGTTGGCTGCACGGGCCGGCTACGGAGGCGTCTTGGCTGTATGGATGGCTCTTTTC ATGACATCCATATCCCTGACACGAGCCTTCTTCATCAGGTTCTACCAGGCTATACTCGCAGCCGGCCTCGCCGTC ATCTTCGCCACCCTCGCCGAGACCGGAAGCCGGCAGGTTGATTGGGCGAAGCTGCGCGACTATGGCTTCTCTTGG TTGTTTGGACAGGCAATCGCCATGGTCATCAATTGTGTCGTCTTTCCCGACGCCGGAGCCAGAGATCTAGCGACG ACGTTTCACGCCGCTTTTGATGTCATGCTTGAGACCCTTGATGCCTCGATATGCCGAGACCGTCGACTCCGTCGG CGCCTGACGCGAACGTTTGTCGACTTGTCGCAAGCATGCCGCGACATGAAAATCGACATTACTGTGACGCGCTTC CGGCCGGACGACGTCGGGGACCTCCGCAATCTGATGCAAGCCGTCATCCGGGCTCTCCTGACCCTCAAGGCCGAC ACTTATCTGTTCAAGCACTCGCCGTCGGAAATCGACGTCACCATTACTGTAGATGAGCCCATCTTGGACGTGACC ACCGGGACTGCAGCCGCGTCTCCGGGTCACAGAAACCTCAGTCGCCGAGCAATCGAAGAGCTAGGCGACCAGACA AAGCACATGCTCTCATGCATGTCTGAGTGCGTTCGGTCTTGCGATGCCGCCCTGATGGACCTGAGCGGACATCGC AGAAATCTTGGTCCCGCGCCGGACGTCTCGTCAGACGTCCTACCAGCACACCGCAAGCTCAGGCGGGCAAAGGCC GCCTACGATGTTGTCGAGGCCAGTCTTATCGAGTCGGAAGAGCATCTGGCGGAGTCTTCCATTCAGGATGGTGAC GTCGTCCAGCTCTTTGTCTTCGCTCGCCACGTCCGCGAAGCCGCCTCCGCCATGGAGCAATTGGTGGACAAGGTC CAGGCCATGAGACTGGCGCTTGGCTGGCCTCGCCCTCATCTGCCGTCGTATCCGTTTTGGAAAGCTCTTCATCGG ACCAACGCTCAGACGCGACATGATCGTGGAGGGGTCACGGCCGGGTCATACCACGTCACCTTCGAGGAGATAGGT CGCTTACTCGATAAGATGAAGTCGAGTGACCACGAGCCCGTGTCAAGAGAAGAAGTAGGCGACGGACCTGGAATC TGCTTGGAGACTTTGGACTCGCACACCTCGTTGGACGCCGGTGTTGGACCGTCCTCGACGGCCAAGACGAGTCGT CTGCGATACAGGATCTGGCGTGTCCTGAAACGTCTGCAAGGCTTTGAAAGCAGATATGCCTTCAAGGTCTGCCTC GTCACCACCCTTCTTTCCATCCCGGCCTATCTGGATAGGGACCGCGGCTGGTGGGAAAAGTACGAGTGTTGGTGG GCCGTCTCCATCAGCTGGCTCGCCATGCACCCCAGAGTTGGGGGCAACGTCCAGGACCTCTTCATCAGGGCCCTC ATGGCGGTCTTGGGCGCCGCGTGGAGTGCGGCGGCGTACGCGGCTGGAAATGGCAACCCCTATGTCATGGCAGCA TTCGCCGCCGTTTACATGACGCCTATGCTGTTCCGCTTTACCCAGAGCTCTCATCCGCGATCCGGCCTGATCGGC TGTCTCTCCTTTACCGTCATCTCGCTGAGACTTCAGGTGGAAAGCGAGGGCACCTCCCCGACACTGCTCGCCGTA TACAGCGGCGTTGCCTTCTTGATTGGCGCCACAGTACCGATCGTCGTGAACTGGGTCCTGTGGCCGTTCGTGGCG AGACACGAGCTGAGACGTGCGCTCTCGTCCATGATGTTCTTCATGAGCGTCATCTATCGAAGCGTCGTGGCGAGA TATGTCTACTTTTACGAGGGCAAGGAGCCCACCCCGGAAGATGTGCAGAGGTCTGAGATGCTCGAAGGACGCCTT AGAGAAGGCTTCGTTCGCATCAGGCAGCTTCTGGTCCTGACGCAAAAGGAGATTCGCCTCCGCGCCCCCTTCGAT CCCTTGCCCTATTCGGCCCTCGCCGACTCGTGCGAGCGCTTCTTCGACTACCTCGTCGCCGTCCGCCAGTCGGCC CTCTTCTACAACCCGGACTACATCCGCGACAACCCCCAGGCGGCGGAGCAGCTCCTCAGCTACCGCCGCGACGCC GTGGCCGCCATCCTCGGAAACCTGTACATACTGGCCGGCGCGCTGCGATCCAAGCGCAAGGTTCCCCGCTACCTC CCCAACGCCGCCGCCGCCCGTAGGAGGCTCCTCATCAAGAACGCCGAGGTCGACGAGGAGATGTCGAGGCGCGCC GGCGCAAGCGACGCAGAGTGGCACAAGCGCTGGTCCGACATCTATCGCTACTCGTACAATGAGAGCCTTGTCGGC TGCGTCGCCCAGCTCGAGGAGCTCGAGAAGCTCACCAAGCTCATCGTCGGCGAGCAG
Transcript	>Ophio5|5467 ATGCCCCATCAGCCTCCAGACGTCCGTCGGCGGCGCCAGCGACATGTTGACATGCGGCCGACGCTCGACCCCGAC GCCTTCCTTGAGCCCGTCTCCCCTCCTCCGACCAGCCGTCGGAGTTCTACCCACAGCCTCGCCCAGCTCGATCAC ATGGTCTCCGACAAGATAGACACGGAGACGTATGGCGTGTCGGAGCTTCGAGACGGCTTCTTCGACGCCATGTTT CTCAGACCGTCCCCCTCGTTCGCTGCCGACCTTTTGCAGGATTCCGCCGACACGCTTCCCGCCGGCTTTGAAAAG GCCTCGCCTTTGACTCTACGCTGCTTCTTTCCCAGGCAGTGGCGAGCCTTGGTGTCCGTCGTGAAGCGCGTCACA ACCACTCGCGCCGGCATCCGACTCCTCAAATCCTTGGTCGCTTTCTTCGTCGCCTACGTCTTGTGTCTCGTGCCT GTCATCCGCGACTGGCTCGGCCGCTATTACTACTTCACCGCCGTATCCGTCATCGTCAACCACCCGGCCAGATCC TTGGGTTCCCAGCTCGACGGCGCGGCTCTCACTGTCGTGGGAGCCGCCTGCGGCTTGGGTTGGGGTGCGCTCGGT CTACTGCTGTCCAAGTCTACGTTGGCTGCACGGGCCGGCTACGGAGGCGTCTTGGCTGTATGGATGGCTCTTTTC ATGACATCCATATCCCTGACACGAGCCTTCTTCATCAGGTTCTACCAGGCTATACTCGCAGCCGGCCTCGCCGTC ATCTTCGCCACCCTCGCCGAGACCGGAAGCCGGCAGGTTGATTGGGCGAAGCTGCGCGACTATGGCTTCTCTTGG TTGTTTGGACAGGCAATCGCCATGGTCATCAATTGTGTCGTCTTTCCCGACGCCGGAGCCAGAGATCTAGCGACG ACGTTTCACGCCGCTTTTGATGTCATGCTTGAGACCCTTGATGCCTCGATATGCCGAGACCGTCGACTCCGTCGG CGCCTGACGCGAACGTTTGTCGACTTGTCGCAAGCATGCCGCGACATGAAAATCGACATTACTGTGACGCGCTTC CGGCCGGACGACGTCGGGGACCTCCGCAATCTGATGCAAGCCGTCATCCGGGCTCTCCTGACCCTCAAGGCCGAC ACTTATCTGTTCAAGCACTCGCCGTCGGAAATCGACGTCACCATTACTGTAGATGAGCCCATCTTGGACGTGACC ACCGGGACTGCAGCCGCGTCTCCGGGTCACAGAAACCTCAGTCGCCGAGCAATCGAAGAGCTAGGCGACCAGACA AAGCACATGCTCTCATGCATGTCTGAGTGCGTTCGGTCTTGCGATGCCGCCCTGATGGACCTGAGCGGACATCGC AGAAATCTTGGTCCCGCGCCGGACGTCTCGTCAGACGTCCTACCAGCACACCGCAAGCTCAGGCGGGCAAAGGCC GCCTACGATGTTGTCGAGGCCAGTCTTATCGAGTCGGAAGAGCATCTGGCGGAGTCTTCCATTCAGGATGGTGAC GTCGTCCAGCTCTTTGTCTTCGCTCGCCACGTCCGCGAAGCCGCCTCCGCCATGGAGCAATTGGTGGACAAGGTC CAGGCCATGAGACTGGCGCTTGGCTGGCCTCGCCCTCATCTGCCGTCGTATCCGTTTTGGAAAGCTCTTCATCGG ACCAACGCTCAGACGCGACATGATCGTGGAGGGGTCACGGCCGGGTCATACCACGTCACCTTCGAGGAGATAGGT CGCTTACTCGATAAGATGAAGTCGAGTGACCACGAGCCCGTGTCAAGAGAAGAAGTAGGCGACGGACCTGGAATC TGCTTGGAGACTTTGGACTCGCACACCTCGTTGGACGCCGGTGTTGGACCGTCCTCGACGGCCAAGACGAGTCGT CTGCGATACAGGATCTGGCGTGTCCTGAAACGTCTGCAAGGCTTTGAAAGCAGATATGCCTTCAAGGTCTGCCTC GTCACCACCCTTCTTTCCATCCCGGCCTATCTGGATAGGGACCGCGGCTGGTGGGAAAAGTACGAGTGTTGGTGG GCCGTCTCCATCAGCTGGCTCGCCATGCACCCCAGAGTTGGGGGCAACGTCCAGGACCTCTTCATCAGGGCCCTC ATGGCGGTCTTGGGCGCCGCGTGGAGTGCGGCGGCGTACGCGGCTGGAAATGGCAACCCCTATGTCATGGCAGCA TTCGCCGCCGTTTACATGACGCCTATGCTGTTCCGCTTTACCCAGAGCTCTCATCCGCGATCCGGCCTGATCGGC TGTCTCTCCTTTACCGTCATCTCGCTGAGACTTCAGGTGGAAAGCGAGGGCACCTCCCCGACACTGCTCGCCGTA TACAGCGGCGTTGCCTTCTTGATTGGCGCCACAGTACCGATCGTCGTGAACTGGGTCCTGTGGCCGTTCGTGGCG AGACACGAGCTGAGACGTGCGCTCTCGTCCATGATGTTCTTCATGAGCGTCATCTATCGAAGCGTCGTGGCGAGA TATGTCTACTTTTACGAGGGCAAGGAGCCCACCCCGGAAGATGTGCAGAGGTCTGAGATGCTCGAAGGACGCCTT AGAGAAGGCTTCGTTCGCATCAGGCAGCTTCTGGTCCTGACGCAAAAGGAGATTCGCCTCCGCGCCCCCTTCGAT CCCTTGCCCTATTCGGCCCTCGCCGACTCGTGCGAGCGCTTCTTCGACTACCTCGTCGCCGTCCGCCAGTCGGCC CTCTTCTACAACCCGGACTACATCCGCGACAACCCCCAGGCGGCGGAGCAGCTCCTCAGCTACCGCCGCGACGCC GTGGCCGCCATCCTCGGAAACCTGTACATACTGGCCGGCGCGCTGCGATCCAAGCGCAAGGTTCCCCGCTACCTC CCCAACGCCGCCGCCGCCCGTAGGAGGCTCCTCATCAAGAACGCCGAGGTCGACGAGGAGATGTCGAGGCGCGCC GGCGCAAGCGACGCAGAGTGGCACAAGCGCTGGTCCGACATCTATCGCTACTCGTACAATGAGAGCCTTGTCGGC TGCGTCGCCCAGCTCGAGGAGCTCGAGAAGCTCACCAAGCTCATCGTCGGCGAGCAGTGA
Gene	>Ophio5|5467 ATGCCCCATCAGCCTCCAGACGTCCGTCGGCGGCGCCAGCGACATGTTGACATGCGGCCGACGCTCGACCCCGAC GCCTTCCTTGAGCCCGTCTCCCCTCCTCCGACCAGCCGTCGGAGTTCTACCCACAGCCTCGCCCAGCTCGATCAC ATGGTCTCCGACAAGATAGACACGGAGACGTATGGCGTGTCGGAGCTTCGAGACGGCTTCTTCGACGCCATGTTT CTCAGACCGTCCCCCTCGTTCGCTGCCGACCTTTTGCAGGATTCCGCCGACACGCTTCCCGCCGGCTTTGAAAAG GCCTCGCCTTTGACTCTACGCTGCTTCTTTCCCAGGCAGTGGCGAGCCTTGGTGTCCGTCGTGAAGCGCGTCACA ACCACTCGCGCCGGCATCCGACTCCTCAAATCCTTGGTCGCTTTCTTCGTCGCCTACGTCTTGTGTCTCGTGCCT GTCATCCGCGACTGGCTCGGCCGCTATTACTACTTCACCGCCGTATCCGTCATCGTCAACCACCCGGCCAGATCC TTGGGTTCCCAGCTCGACGGCGCGGCTCTCACTGTCGTGGGAGCCGCCTGCGGCTTGGGTTGGGGTGCGCTCGGT CTACTGCTGTCCAAGTCTACGTTGGCTGCACGGGCCGGCTACGGAGGCGTCTTGGCTGTATGGATGGCTCTTTTC ATGACATCCATATCCCTGACACGAGCCTTCTTCATCAGGTTCTACCAGGCTATACTCGCAGCCGGCCTCGCCGTC ATCTTCGCCACCCTCGCCGAGACCGGAAGCCGGCAGGTTGATTGGGCGAAGCTGCGCGACTATGGCTTCTCTTGG TTGTTTGGACAGGCAATCGCCATGGTCATCAATTGTGTCGTCTTTCCCGACGCCGGAGCCAGAGATCTAGCGACG ACGTTTCACGCCGCTTTTGATGTCATGCTTGTACGTCCGTCAGCACAGACCGCAACGTCTTGTCGCTAATTGATT TGCCGCAGGAGACCCTTGATGCCTCGATATGCCGAGACCGTCGACTCCGTCGGCGCCTGACGCGAACGTTTGTCG ACTTGTCGCAAGCATGCCGCGACATGAAAATCGACATTACTGTGACGCGCTTCCGGCCGGACGACGTCGGGGACC TCCGCAATCTGATGCAAGCCGTCATCCGGGCTCTCCTGACCCTCAAGGCCGACACTTATCTGTTCAAGCACTCGC CGTCGGAAATCGACGTCACCATTACTGTAGATGAGCCCATCTTGGACGTGACCACCGGGACTGCAGCCGCGTCTC CGGGTCACAGAAACCTCAGTCGCCGAGCAATCGAAGAGCTAGGCGACCAGACAAAGCACATGCTCTCATGCATGT CTGAGTGCGTTCGGTCTTGCGATGCCGCCCTGATGGACCTGAGCGGACATCGCAGAAATCTTGGTCCCGCGCCGG ACGTCTCGTCAGACGTCCTACCAGCACACCGCAAGCTCAGGCGGGCAAAGGCCGCCTACGATGTTGTCGAGGCCA GTCTTATCGAGTCGGAAGAGCATCTGGCGGAGTCTTCCATTCAGGATGGTGACGTCGTCCAGCTCTTTGTCTTCG CTCGCCACGTCCGCGAAGCCGCCTCCGCCATGGAGCAATTGGTGGACAAGGTCCAGGCCATGAGACTGGCGCTTG GCTGGCCTCGCCCTCATCTGCCGTCGTATCCGTTTTGGAAAGCTCTTCATCGGACCAACGCTCAGACGCGACATG ATCGTGGAGGGGTCACGGCCGGGTCATACCACGTCACCTTCGAGGAGATAGGTCGCTTACTCGATAAGATGAAGT CGAGTGACCACGAGCCCGTGTCAAGAGAAGAAGTAGGCGACGGACCTGGAATCTGCTTGGAGACTTTGGACTCGC ACACCTCGTTGGACGCCGGTGTTGGACCGTCCTCGACGGCCAAGACGAGTCGTCTGCGATACAGGATCTGGCGTG TCCTGAAACGTCTGCAAGGCTTTGAAAGCAGATATGCCTTCAAGGTCTGCCTCGTCACCACCCTTCTTTCCATCC CGGCCTATCTGGATAGGGACCGCGGCTGGTGGGAAAAGTACGAGTGTTGGTGGGCCGTCTCCATCAGCTGGCTCG CCATGCACCCCAGAGTTGGGGGCAACGTCCAGGACCTCTTCATCAGGGCCCTCATGGCGGTCTTGGGCGCCGCGT GGAGTGCGGCGGCGTACGCGGCTGGAAATGGCAACCCCTATGTCATGGCAGCATTCGCCGCCGTTTACATGACGC CTATGCTGTTCCGCTTTACCCAGAGCTCTCATCCGGTGAGTCGGGGCGCTCCTCGAGACGTGCCACGAGCTGACG ACGATACCAGCGATCCGGCCTGATCGGCTGTCTCTCCTTTACCGTCATCTCGCTGAGACTTCAGGTGGAAAGCGA GGGCACCTCCCCGACACTGCTCGCCGTATACAGCGGCGTTGCCTTCTTGATTGGCGCCACAGTACCGATCGTCGT GAACTGGGTCCTGTGGCCGTTCGTGGCGAGACACGAGCTGAGACGTGCGCTCTCGTCCATGATGTTCTTCATGAG CGTCATCTATCGAAGTATGGCTTGACCGGCCACGCCCCCCTTGGGCTCTCGTTGCTAATTCGCGGCAGGCGTCGT GGCGAGATATGTCTACTTTTACGAGGGCAAGGAGCCCACCCCGGAAGATGTGCAGAGGTCTGAGATGCTCGAAGG ACGCCTTAGAGAAGGCTTCGTTCGCATCAGGCAGCTTCTGGTAAGTGGTGGCGTCCACCCCCCCCCCCAAAAAAG GGGGGGGGGGGGGGGGGGGTTTCGGGATCACGCCTCTCACACAGCCTCGCAGGTCCTGACGCAAAAGGAGATTCG CCTCCGCGCCCCCTTCGATCCCTTGCCCTATTCGGCCCTCGCCGACTCGTGCGAGCGCTTCTTCGACTACCTCGT CGCCGTCCGCCAGTCGGCCCTCTTCTACAACCCGGACTACATCCGCGACAACCCCCAGGCGGCGGAGCAGCTCCT CAGCTACCGCCGCGACGCCGTGGCCGCCATCCTCGGAAACCTGTACATACTGGCCGGCGCGCTGCGATCCAAGCG CAAGGTTCCCGTGAGTTGCCCTCGTTCCCTGCTTGGTGGCCAAACATGGTTCGCGCTGCTGACGCTGTACCCTTC ATTTCCCCCAAAGCGCTACCTCCCCAACGCCGCCGCCGCCCGTAGGAGGCTCCTCATCAAGAACGCCGAGGTCGA CGAGGAGATGTCGAGGCGCGCCGGCGCAAGCGACGCAGAGTGGCACAAGCGCTGGTCCGACATCTATCGCTACTC GTACAATGAGAGCCTTGTCGGCTGCGTCGCCCAGCTCGAGGAGCTCGAGAAGCTCACCAAGCTCATCGTCGGCGA GCAGTGA