Fungal Genomics

at Utrecht University

General Properties

Protein IDOphio5|4731
Gene name
Locationscaffold_379:2284..5461
Strand-
Gene length (bp)3177
Transcript length (bp)2739
Coding sequence length (bp)2736
Protein length (aa) 912

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PFAM Domains

PFAM Domain ID Short name Long name E-value Start End
PF01028 Topoisom_I Eukaryotic DNA topoisomerase I, catalytic core 1.1E-95 500 730
PF02919 Topoisom_I_N Eukaryotic DNA topoisomerase I, DNA binding fragment 9.6E-93 270 496
PF14370 Topo_C_assoc C-terminal topoisomerase domain 3.3E-29 840 912

Swissprot hits

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Swissprot ID Swissprot Description Start End E-value
sp|P07799|TOP1_SCHPO DNA topoisomerase 1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=top1 PE=1 SV=2 128 912 0.0E+00
sp|P04786|TOP1_YEAST DNA topoisomerase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TOP1 PE=1 SV=2 126 912 0.0E+00
sp|Q00313|TOP1_CANAX DNA topoisomerase 1 OS=Candida albicans GN=TOP1 PE=3 SV=1 129 912 0.0E+00
sp|A9Q1D5|TOP1M_PANTR DNA topoisomerase I, mitochondrial OS=Pan troglodytes GN=TOP1MT PE=2 SV=1 260 719 1.0E-144
sp|Q969P6|TOP1M_HUMAN DNA topoisomerase I, mitochondrial OS=Homo sapiens GN=TOP1MT PE=1 SV=1 260 719 3.0E-144
[Show all]
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Swissprot ID Swissprot Description Start End E-value
sp|P07799|TOP1_SCHPO DNA topoisomerase 1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=top1 PE=1 SV=2 128 912 0.0E+00
sp|P04786|TOP1_YEAST DNA topoisomerase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TOP1 PE=1 SV=2 126 912 0.0E+00
sp|Q00313|TOP1_CANAX DNA topoisomerase 1 OS=Candida albicans GN=TOP1 PE=3 SV=1 129 912 0.0E+00
sp|A9Q1D5|TOP1M_PANTR DNA topoisomerase I, mitochondrial OS=Pan troglodytes GN=TOP1MT PE=2 SV=1 260 719 1.0E-144
sp|Q969P6|TOP1M_HUMAN DNA topoisomerase I, mitochondrial OS=Homo sapiens GN=TOP1MT PE=1 SV=1 260 719 3.0E-144
sp|P30189|TOP1_DROME DNA topoisomerase 1 OS=Drosophila melanogaster GN=Top1 PE=1 SV=1 268 721 7.0E-141
sp|P41512|TOP1_XENLA DNA topoisomerase 1 OS=Xenopus laevis GN=top1 PE=2 SV=1 265 717 1.0E-140
sp|P11387|TOP1_HUMAN DNA topoisomerase 1 OS=Homo sapiens GN=TOP1 PE=1 SV=2 265 717 2.0E-140
sp|Q7YR26|TOP1_CHLAE DNA topoisomerase 1 OS=Chlorocebus aethiops GN=TOP1 PE=2 SV=1 265 717 1.0E-139
sp|Q9WUL0|TOP1_RAT DNA topoisomerase 1 OS=Rattus norvegicus GN=Top1 PE=1 SV=1 265 717 6.0E-138
sp|Q04750|TOP1_MOUSE DNA topoisomerase 1 OS=Mus musculus GN=Top1 PE=1 SV=2 265 717 6.0E-138
sp|Q8R4U6|TOP1M_MOUSE DNA topoisomerase I, mitochondrial OS=Mus musculus GN=Top1mt PE=2 SV=1 269 717 1.0E-137
sp|Q6IM78|TOP1M_RAT DNA topoisomerase I, mitochondrial OS=Rattus norvegicus GN=Top1mt PE=2 SV=1 269 717 2.0E-137
sp|Q54RC3|TOP1_DICDI DNA topoisomerase 1 OS=Dictyostelium discoideum GN=top1 PE=3 SV=1 271 900 5.0E-137
sp|Q07050|TOP1_CRIGR DNA topoisomerase 1 OS=Cricetulus griseus GN=TOP1 PE=2 SV=1 265 717 6.0E-136
sp|O17966|TOP1_CAEEL DNA topoisomerase 1 OS=Caenorhabditis elegans GN=top-1 PE=2 SV=1 252 713 1.0E-130
sp|P30181|TOP1_ARATH DNA topoisomerase 1 OS=Arabidopsis thaliana GN=TOP1 PE=1 SV=1 271 721 5.0E-127
sp|P41511|TOP1_USTMA DNA topoisomerase 1 OS=Ustilago maydis (strain 521 / FGSC 9021) GN=TOP1 PE=3 SV=2 271 882 2.0E-120
sp|P93119|TOP1_DAUCA DNA topoisomerase 1 OS=Daucus carota GN=TOP1 PE=2 SV=1 273 904 2.0E-120
sp|Q04750|TOP1_MOUSE DNA topoisomerase 1 OS=Mus musculus GN=Top1 PE=1 SV=2 828 912 1.0E-17
sp|Q9WUL0|TOP1_RAT DNA topoisomerase 1 OS=Rattus norvegicus GN=Top1 PE=1 SV=1 828 912 1.0E-17
sp|Q7YR26|TOP1_CHLAE DNA topoisomerase 1 OS=Chlorocebus aethiops GN=TOP1 PE=2 SV=1 828 912 1.0E-17
sp|P11387|TOP1_HUMAN DNA topoisomerase 1 OS=Homo sapiens GN=TOP1 PE=1 SV=2 828 912 1.0E-17
sp|Q07050|TOP1_CRIGR DNA topoisomerase 1 OS=Cricetulus griseus GN=TOP1 PE=2 SV=1 828 912 1.0E-17
sp|O17966|TOP1_CAEEL DNA topoisomerase 1 OS=Caenorhabditis elegans GN=top-1 PE=2 SV=1 824 909 1.0E-17
sp|A9Q1D5|TOP1M_PANTR DNA topoisomerase I, mitochondrial OS=Pan troglodytes GN=TOP1MT PE=2 SV=1 819 912 2.0E-16
sp|Q969P6|TOP1M_HUMAN DNA topoisomerase I, mitochondrial OS=Homo sapiens GN=TOP1MT PE=1 SV=1 819 912 3.0E-16
sp|P30189|TOP1_DROME DNA topoisomerase 1 OS=Drosophila melanogaster GN=Top1 PE=1 SV=1 830 901 8.0E-16
sp|Q6IM78|TOP1M_RAT DNA topoisomerase I, mitochondrial OS=Rattus norvegicus GN=Top1mt PE=2 SV=1 838 912 9.0E-14
sp|Q8R4U6|TOP1M_MOUSE DNA topoisomerase I, mitochondrial OS=Mus musculus GN=Top1mt PE=2 SV=1 765 912 1.0E-13
sp|P41512|TOP1_XENLA DNA topoisomerase 1 OS=Xenopus laevis GN=top1 PE=2 SV=1 812 894 2.0E-13
sp|P30181|TOP1_ARATH DNA topoisomerase 1 OS=Arabidopsis thaliana GN=TOP1 PE=1 SV=1 765 901 7.0E-11
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GO

GO Term Description Terminal node
GO:0003677 DNA binding Yes
GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity Yes
GO:0006265 DNA topological change Yes
GO:0016853 isomerase activity No
GO:0140097 catalytic activity, acting on DNA No
GO:0008152 metabolic process No
GO:0044237 cellular metabolic process No
GO:0006139 nucleobase-containing compound metabolic process No
GO:0046483 heterocycle metabolic process No
GO:0003676 nucleic acid binding No
GO:0044260 cellular macromolecule metabolic process No
GO:0090304 nucleic acid metabolic process No
GO:0044238 primary metabolic process No
GO:0006259 DNA metabolic process No
GO:0051276 chromosome organization No
GO:0006725 cellular aromatic compound metabolic process No
GO:0008150 biological_process No
GO:1901360 organic cyclic compound metabolic process No
GO:0003674 molecular_function No
GO:0140640 catalytic activity, acting on a nucleic acid No
GO:0071103 DNA conformation change No
GO:0071704 organic substance metabolic process No
GO:0005488 binding No
GO:0043170 macromolecule metabolic process No
GO:0009987 cellular process No
GO:1901363 heterocyclic compound binding No
GO:0016043 cellular component organization No
GO:0097159 organic cyclic compound binding No
GO:0006807 nitrogen compound metabolic process No
GO:0003824 catalytic activity No
GO:0034641 cellular nitrogen compound metabolic process No
GO:0071840 cellular component organization or biogenesis No
GO:0006996 organelle organization No
GO:0003916 DNA topoisomerase activity No

SignalP

[Help with interpreting these statistics]
SignalP signal predicted Location
(based on Ymax)
D score
(significance: > 0.45)
No 1 - 12 0.45

Transmembrane Domains

(None)

Transcription Factor Class

(None)

Expression data

Analysis 1: Expression analysis during behavioral modification. Published in De Bekker et al., 2017.

Click here for more information

Sequences

Type of sequenceSequence
Locus Download genbank file of locus
The gene with 5 kb flanks (if sufficient flanking sequence is available). For use in cloning design programs. NOTE: features (genes or exons) that are only partially contained within the sequence are completely excluded.
Protein >Ophio5|4731
MGSDSSDDDVPLARPNGRLSSSKISRAEDIAMDRAVPGGNTDLAGLSVRNGPVQEVKDNNTNGTNKRKSRSSISA
VNYKDESDSDGEPLAKRSKPALKGASSDSDDEPLGKSRIKKLPPSYEETALPESSDDDKPLGARLAQKKAAIEKR
AEDEAKAIRAKEAKAKKATAQKKVKKESDDEPLARSSKAKPKRQSNGGTAKRKSNGVKKEDSDSDAPIAKKPKVK
AEATPKRAKATTPAKDSKSAKSKEASDDDEEYQWWNAPKREDDTIKWQTLEHNGVLFAPEYEPLPKNVHLLYDGK
PVNLSKEAEEVATFWVAMMTPASSHHLDNAVFRKNFFNDFSEYVNKDGATDTKGAKVEIKSLDKCDFSKIYEYWS
AKTEANKNKNLSKDEREAAKAKKEALEAPYLHCTWDGRKQKVGNFRVEPPSLFRGRGEHPKTGRVKTRVLPEQIT
INIGKDAKVPNPPSGHKWKAVQHDQRATWLAMWQENINGAYKYVMLGAASDVKGQSDFKKFEKARELKKHIDKIR
KDYTRDLKSEVMADRQRATAMYLIDKLALRAGNEKDTENEADTVGCCSLKYEHITLEAPDKVTFDFLGKDSIRYN
ETAHVDAQVFKNLKLFKKPPKTDGDDLFDRLNTSQLNKHLNSCMAGLTAKVFRTYNASFVMSELLKELHNDPRSK
GTIAEKVKLYNDCNRKVAILCNHKRTVGAGHEQQMQKLGDRIKGLRYQKWRTKKMILDIDTTQKKKKGAAWFEMD
EDLDEEWIKEHQQYLIEEQRTKVTKKFEKENEKLKATKEKPMPDKELKERLQSVKELEQKFKKENKSGKVEAEGR
GPTVEKFLKAIEKLDERVKVLETQAEDRDGNKEVALSTSKLNYIDPRLTVVFSKKFDVPIEKFFSKTLRDKFRWA
IKSVEDADDWEF
Coding >Ophio5|4731
ATGGGTTCCGACAGCTCCGACGATGATGTGCCTTTGGCGAGGCCGAATGGTCGCTTGTCCTCGTCCAAGATTTCC
CGCGCCGAGGATATTGCCATGGATCGCGCCGTGCCGGGCGGGAACACGGATTTGGCAGGGCTTTCAGTGCGCAAT
GGCCCTGTTCAAGAGGTCAAGGACAACAATACGAACGGTACCAACAAGCGCAAGTCGCGATCGTCCATCTCCGCC
GTCAACTACAAGGACGAATCCGACAGCGACGGCGAGCCTTTGGCAAAACGATCGAAGCCCGCTCTCAAGGGCGCA
AGCTCCGACTCCGATGATGAGCCGCTGGGCAAGTCGCGAATCAAGAAGTTGCCTCCTTCCTACGAGGAGACGGCA
CTCCCCGAGTCATCGGACGACGACAAGCCTCTGGGCGCCAGGCTTGCTCAGAAGAAGGCGGCCATCGAGAAACGT
GCGGAGGATGAGGCCAAGGCGATCCGCGCCAAGGAGGCAAAGGCGAAAAAGGCCACAGCACAGAAAAAGGTCAAG
AAGGAATCCGACGATGAACCTCTGGCCCGATCCTCCAAGGCGAAGCCAAAGCGCCAGTCAAATGGAGGTACCGCC
AAGAGGAAATCAAACGGTGTCAAGAAAGAGGATTCCGACTCCGATGCTCCCATCGCCAAAAAGCCAAAGGTCAAG
GCCGAGGCTACTCCCAAGAGGGCCAAGGCAACCACGCCTGCCAAAGATTCGAAAAGCGCAAAGTCCAAGGAAGCG
AGCGACGATGACGAAGAGTACCAGTGGTGGAACGCTCCCAAGCGCGAGGACGACACCATCAAGTGGCAGACTCTC
GAGCACAACGGTGTGCTCTTCGCCCCCGAGTACGAGCCCCTTCCCAAAAACGTCCATCTCCTCTACGACGGAAAG
CCCGTAAACCTCAGCAAGGAGGCCGAGGAGGTGGCCACCTTCTGGGTTGCCATGATGACGCCAGCCTCGTCTCAT
CACCTGGACAATGCTGTCTTTCGCAAGAACTTCTTCAACGACTTTTCGGAATACGTCAACAAGGACGGCGCGACG
GATACCAAAGGCGCAAAGGTCGAGATTAAGAGCCTCGATAAGTGTGACTTTTCTAAGATTTACGAGTACTGGTCG
GCCAAGACCGAGGCCAATAAGAACAAGAACCTGTCCAAGGATGAGAGGGAGGCGGCCAAGGCCAAGAAGGAGGCT
CTAGAGGCCCCCTACCTCCACTGCACGTGGGACGGCAGAAAGCAAAAAGTGGGCAACTTCAGGGTCGAACCTCCC
AGTCTTTTCCGCGGCCGAGGCGAACATCCCAAGACGGGCCGAGTCAAGACGCGGGTGCTGCCTGAGCAGATCACC
ATCAACATCGGCAAAGACGCAAAGGTGCCGAACCCGCCGTCGGGACACAAGTGGAAGGCCGTCCAGCACGATCAA
CGGGCCACGTGGCTGGCCATGTGGCAGGAGAACATCAACGGCGCCTACAAGTACGTGATGCTGGGGGCTGCCAGC
GACGTCAAGGGCCAAAGCGACTTCAAGAAGTTTGAGAAGGCCCGGGAGCTGAAGAAGCACATCGACAAGATCCGC
AAAGACTACACCCGGGACCTGAAGAGCGAGGTCATGGCCGACCGTCAGCGGGCCACCGCCATGTACCTGATCGAC
AAGCTCGCCCTCCGAGCCGGGAACGAAAAGGACACGGAGAACGAGGCCGACACGGTGGGCTGCTGCTCGCTCAAG
TACGAGCACATTACGCTGGAGGCGCCGGACAAGGTCACCTTTGACTTCTTGGGCAAGGACAGCATCCGGTACAAC
GAGACGGCGCACGTGGACGCTCAGGTCTTCAAGAACCTAAAGCTGTTCAAGAAGCCGCCGAAGACGGACGGAGAC
GACCTCTTCGATCGGCTCAATACGTCACAACTCAACAAGCACCTGAACAGCTGCATGGCTGGGCTGACGGCCAAG
GTGTTCCGAACGTACAACGCGTCCTTTGTCATGTCGGAGCTCCTCAAGGAGCTACACAACGACCCGCGTTCCAAG
GGCACCATCGCCGAGAAGGTGAAGCTGTACAACGACTGCAACCGAAAAGTCGCCATCCTCTGCAACCACAAGAGA
ACCGTCGGAGCCGGACACGAACAGCAAATGCAGAAGCTAGGAGATAGAATCAAAGGCCTGCGTTACCAAAAGTGG
CGGACCAAGAAGATGATTCTCGACATCGACACGACGCAGAAGAAGAAGAAGGGGGCCGCGTGGTTCGAGATGGAC
GAGGACCTGGACGAGGAGTGGATCAAGGAGCATCAACAGTACCTGATCGAGGAGCAACGCACCAAGGTGACGAAG
AAGTTTGAGAAGGAAAACGAGAAACTCAAGGCGACCAAGGAAAAGCCGATGCCAGACAAGGAGCTCAAGGAGCGA
CTTCAGTCTGTCAAGGAGCTCGAGCAAAAGTTCAAGAAGGAGAACAAGTCGGGCAAGGTGGAGGCCGAGGGCCGG
GGCCCGACGGTGGAAAAGTTCCTCAAGGCCATTGAGAAGCTCGACGAACGGGTCAAGGTGCTGGAGACGCAGGCC
GAGGACCGCGACGGCAACAAGGAAGTTGCACTGAGCACATCCAAGCTGAATTACATCGACCCGCGTCTTACCGTG
GTCTTTTCCAAGAAGTTTGACGTGCCGATTGAGAAGTTCTTTTCCAAGACGCTTAGGGACAAGTTCCGATGGGCC
ATCAAGTCGGTGGAAGACGCGGATGACTGGGAATTT
Transcript >Ophio5|4731
ATGGGTTCCGACAGCTCCGACGATGATGTGCCTTTGGCGAGGCCGAATGGTCGCTTGTCCTCGTCCAAGATTTCC
CGCGCCGAGGATATTGCCATGGATCGCGCCGTGCCGGGCGGGAACACGGATTTGGCAGGGCTTTCAGTGCGCAAT
GGCCCTGTTCAAGAGGTCAAGGACAACAATACGAACGGTACCAACAAGCGCAAGTCGCGATCGTCCATCTCCGCC
GTCAACTACAAGGACGAATCCGACAGCGACGGCGAGCCTTTGGCAAAACGATCGAAGCCCGCTCTCAAGGGCGCA
AGCTCCGACTCCGATGATGAGCCGCTGGGCAAGTCGCGAATCAAGAAGTTGCCTCCTTCCTACGAGGAGACGGCA
CTCCCCGAGTCATCGGACGACGACAAGCCTCTGGGCGCCAGGCTTGCTCAGAAGAAGGCGGCCATCGAGAAACGT
GCGGAGGATGAGGCCAAGGCGATCCGCGCCAAGGAGGCAAAGGCGAAAAAGGCCACAGCACAGAAAAAGGTCAAG
AAGGAATCCGACGATGAACCTCTGGCCCGATCCTCCAAGGCGAAGCCAAAGCGCCAGTCAAATGGAGGTACCGCC
AAGAGGAAATCAAACGGTGTCAAGAAAGAGGATTCCGACTCCGATGCTCCCATCGCCAAAAAGCCAAAGGTCAAG
GCCGAGGCTACTCCCAAGAGGGCCAAGGCAACCACGCCTGCCAAAGATTCGAAAAGCGCAAAGTCCAAGGAAGCG
AGCGACGATGACGAAGAGTACCAGTGGTGGAACGCTCCCAAGCGCGAGGACGACACCATCAAGTGGCAGACTCTC
GAGCACAACGGTGTGCTCTTCGCCCCCGAGTACGAGCCCCTTCCCAAAAACGTCCATCTCCTCTACGACGGAAAG
CCCGTAAACCTCAGCAAGGAGGCCGAGGAGGTGGCCACCTTCTGGGTTGCCATGATGACGCCAGCCTCGTCTCAT
CACCTGGACAATGCTGTCTTTCGCAAGAACTTCTTCAACGACTTTTCGGAATACGTCAACAAGGACGGCGCGACG
GATACCAAAGGCGCAAAGGTCGAGATTAAGAGCCTCGATAAGTGTGACTTTTCTAAGATTTACGAGTACTGGTCG
GCCAAGACCGAGGCCAATAAGAACAAGAACCTGTCCAAGGATGAGAGGGAGGCGGCCAAGGCCAAGAAGGAGGCT
CTAGAGGCCCCCTACCTCCACTGCACGTGGGACGGCAGAAAGCAAAAAGTGGGCAACTTCAGGGTCGAACCTCCC
AGTCTTTTCCGCGGCCGAGGCGAACATCCCAAGACGGGCCGAGTCAAGACGCGGGTGCTGCCTGAGCAGATCACC
ATCAACATCGGCAAAGACGCAAAGGTGCCGAACCCGCCGTCGGGACACAAGTGGAAGGCCGTCCAGCACGATCAA
CGGGCCACGTGGCTGGCCATGTGGCAGGAGAACATCAACGGCGCCTACAAGTACGTGATGCTGGGGGCTGCCAGC
GACGTCAAGGGCCAAAGCGACTTCAAGAAGTTTGAGAAGGCCCGGGAGCTGAAGAAGCACATCGACAAGATCCGC
AAAGACTACACCCGGGACCTGAAGAGCGAGGTCATGGCCGACCGTCAGCGGGCCACCGCCATGTACCTGATCGAC
AAGCTCGCCCTCCGAGCCGGGAACGAAAAGGACACGGAGAACGAGGCCGACACGGTGGGCTGCTGCTCGCTCAAG
TACGAGCACATTACGCTGGAGGCGCCGGACAAGGTCACCTTTGACTTCTTGGGCAAGGACAGCATCCGGTACAAC
GAGACGGCGCACGTGGACGCTCAGGTCTTCAAGAACCTAAAGCTGTTCAAGAAGCCGCCGAAGACGGACGGAGAC
GACCTCTTCGATCGGCTCAATACGTCACAACTCAACAAGCACCTGAACAGCTGCATGGCTGGGCTGACGGCCAAG
GTGTTCCGAACGTACAACGCGTCCTTTGTCATGTCGGAGCTCCTCAAGGAGCTACACAACGACCCGCGTTCCAAG
GGCACCATCGCCGAGAAGGTGAAGCTGTACAACGACTGCAACCGAAAAGTCGCCATCCTCTGCAACCACAAGAGA
ACCGTCGGAGCCGGACACGAACAGCAAATGCAGAAGCTAGGAGATAGAATCAAAGGCCTGCGTTACCAAAAGTGG
CGGACCAAGAAGATGATTCTCGACATCGACACGACGCAGAAGAAGAAGAAGGGGGCCGCGTGGTTCGAGATGGAC
GAGGACCTGGACGAGGAGTGGATCAAGGAGCATCAACAGTACCTGATCGAGGAGCAACGCACCAAGGTGACGAAG
AAGTTTGAGAAGGAAAACGAGAAACTCAAGGCGACCAAGGAAAAGCCGATGCCAGACAAGGAGCTCAAGGAGCGA
CTTCAGTCTGTCAAGGAGCTCGAGCAAAAGTTCAAGAAGGAGAACAAGTCGGGCAAGGTGGAGGCCGAGGGCCGG
GGCCCGACGGTGGAAAAGTTCCTCAAGGCCATTGAGAAGCTCGACGAACGGGTCAAGGTGCTGGAGACGCAGGCC
GAGGACCGCGACGGCAACAAGGAAGTTGCACTGAGCACATCCAAGCTGAATTACATCGACCCGCGTCTTACCGTG
GTCTTTTCCAAGAAGTTTGACGTGCCGATTGAGAAGTTCTTTTCCAAGACGCTTAGGGACAAGTTCCGATGGGCC
ATCAAGTCGGTGGAAGACGCGGATGACTGGGAATTTTGA
Gene >Ophio5|4731
ATGGGTTCCGACAGCTCCGACGATGATGTGCCTTTGGCGAGGCCGAATGGTCGCTGTGAGTCACCTTGTTTTTCC
CTTTCAAGCCTGTCTCTGCTTTGTTTTTCGGTCTTTTTTTTTTCCCCTGTTTTTCTTTTCCTTTCAGCCTTTCAA
ATAAAAAGGGCGATCCAACGCAGGCGGTGGTCACCTTCCAACGACGCCCTCGTTCCAACCGACCCCATCGCGCTG
TCAGCGCCGTGCAACTGACAAACTCTGCTCACTCTCTCTCTCTCTCTAGTGTCCTCGTCCAAGATTTCCCGCGCC
GAGGATATTGCCATGGATCGCGCCGTGCCGGGCGGGAACACGGATTTGGCAGGGCTTTCAGTGCGCAATGGCCCT
GTTCAAGAGGTCAAGGACAACAATACGAACGGTACCAACAAGCGCAAGTCGCGATCGTCCATCTCCGCCGTCAAC
TACAAGGACGAATCCGACAGCGACGGCGAGCCTTTGGTAAGAGCCGTTCCACTTCTGCAGCTGCAACGCCTCACG
ATGCTTACTGCAGACGCCAGGCAAAACGATCGAAGCCCGCTCTCAAGGGCGCAAGCTCCGACTCCGATGATGAGC
CGCTGGGCAAGTCGCGAATCAAGAAGTTGCCTCCTTCCTACGAGGAGACGGCACTCCCCGAGTCATCGGACGACG
ACAAGCCTCTGGGCGCCAGGCTTGCTCAGAAGAAGGCGGCCATCGAGAAACGTGCGGAGGATGAGGCCAAGGCGA
TCCGCGCCAAGGAGGCAAAGGCGAAAAAGGCCACAGCACAGAAAAAGGTCAAGAAGGAATCCGACGATGAACCTC
TGGCCCGATCCTCCAAGGCGAAGCCAAAGCGCCAGTCAAATGGAGGTACCGCCAAGAGGAAATCAAACGGTGTCA
AGAAAGAGGATTCCGACTCCGATGCTCCCATCGCCAAAAAGCCAAAGGTCAAGGCCGAGGCTACTCCCAAGAGGG
CCAAGGCAACCACGCCTGCCAAAGATTCGAAAAGCGCAAAGTCCAAGGAAGCGAGCGACGATGACGAAGAGTACC
AGTGGTGGAACGCTCCCAAGCGCGAGGACGACACCATCAAGTGGCAGACTCTCGAGCACAACGGTGTGCTCTTCG
CCCCCGAGTACGAGCCCCTTCCCAAAAACGTCCATCTCCTCTACGACGGAAAGCCCGTAAACCTCAGCAAGGAGG
CCGAGGAGGTGGCCACCTTCTGGGTTGCCATGATGACGCCAGCCTCGTCTCATCACCTGGACAATGCTGTCTTTC
GCAAGAACTTCTTCAACGACTTTTCGGAATACGTCAACAAGGACGGCGCGACGGATACCAAAGGCGCAAAGGTCG
AGATTAAGAGCCTCGATAAGTGTGACTTTTCTAAGATTTACGAGTACTGGTCGGCCAAGACCGAGGCCAATAAGA
ACAAGAACCTGTCCAAGGATGAGAGGGAGGCGGCCAAGGCCAAGAAGGAGGCTCTAGAGGCCCCCTACCTCCACT
GCACGTGGGACGGCAGAAAGCAAAAAGTGGGCAACTTCAGGGTCGAACCTCCCAGTCTTTTCCGCGGCCGAGGCG
AACATCCCAAGACGGGCCGAGTCAAGACGCGGGTGCTGCCTGAGCAGATCACCATCAACATCGGCAAAGACGCAA
AGGTGCCGAACCCGCCGTCGGGACACAAGTGGAAGGCCGTCCAGCACGATCAACGGGCCACGTGGCTGGCCATGT
GGCAGGAGAACATCAACGGCGCCTACAAGTACGTGATGCTGGGGGCTGCCAGCGACGTCAAGGGCCAAAGCGACT
TCAAGAAGTTTGAGAAGGCCCGGGAGCTGAAGAAGCACATCGACAAGATCCGCAAAGACTACACCCGGGACCTGA
AGAGCGAGGTCATGGCCGACCGTCAGCGGGCCACCGCCATGTACCTGATCGACAAGCTCGCCCTCCGAGCCGGGA
ACGAAAAGGACACGGAGAACGAGGCCGACACGGTGGGCTGCTGCTCGCTCAAGTACGAGCACATTACGCTGGAGG
CGCCGGACAAGGTCACCTTTGACTTCTTGGGCAAGGACAGCATCCGGTACAACGAGACGGCGCACGTGGACGCTC
AGGTCTTCAAGAACCTAAAGCTGTTCAAGAAGCCGCCGAAGACGGACGGAGACGACCTCTTCGATCGGCTCAATG
TCGGTAGCACCAAAGACACGGTGCGCGCATCCTGCTAACCTGGGTCGACAGACGTCACAACTCAACAAGCACCTG
AACAGCTGCATGGCTGGGCTGACGGCCAAGGTGTTCCGAACGTACAACGCGTCCTTTGTCATGTCGGAGCTCCTC
AAGGAGCTACACAACGACCCGCGTTCCAAGGGCACCATCGCCGAGAAGGTGAAGCTGTACAACGACTGCAACCGA
AAAGTCGCCATCCTCTGCAACCACAAGAGAACCGTCGGAGCCGGACACGAACAGCAAATGCAGAAGCTAGGAGAT
AGAGTGAGCAGGAGCCACTTTACCTCATGTGATGAGGCTCGCTGACGTAAATCCAGATCAAAGGCCTGCGTTACC
AAAAGTGGCGGACCAAGAAGATGATTCTCGACATCGACACGACGCAGAAGAAGAAGAAGGGGGCCGCGTGGTTCG
AGATGGACGAGGACCTGGACGAGGAGTGGATCAAGGAGCATCAACAGTACCTGATCGAGGAGCAACGCACCAAGG
TGACGAAGAAGTTTGAGAAGGAAAACGAGAAACTCAAGGCGACCAAGGAAAAGCCGATGCCAGACAAGGAGCTCA
AGGAGCGACTTCAGTCTGTCAAGGAGCTCGAGCAAAAGTTCAAGAAGGAGAACAAGTCGGGCAAGGTGGAGGCCG
AGGGCCGGGGCCCGACGGTGGAAAAGTTCCTCAAGGCCATTGAGAAGCTCGACGAACGGGTCAAGGTGCTGGAGA
CGCAGGCCGAGGACCGCGACGGCAACAAGGAAGTTGCACTGAGCACATCCAAGCTGGCGAGTATCGACGGCCGAT
GGCCCAGTGGCTGGGAATGCTAACTGGGGACTACAGAATTACATCGACCCGCGTCTTACCGTGGTCTTTTCCAAG
AAGTTTGACGTGCCGATTGAGAAGTTCTTTTCCAAGACGCTTAGGGACAAGTTCCGATGGGCCATCAAGTCGGTG
GAAGACGCGGATGACTGGGAATTTTGA

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