© 2022 - Robin Ohm - Utrecht University - The Netherlands
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| Protein ID | Ophio5|4573 |
| Gene name | |
| Location | scaffold_364:15427..18108 |
| Strand | + |
| Gene length (bp) | 2681 |
| Transcript length (bp) | 2241 |
| Coding sequence length (bp) | 2238 |
| Protein length (aa) | 746 |
| PFAM Domain ID | Short name | Long name | E-value | Start | End |
|---|---|---|---|---|---|
| PF01699 | Na_Ca_ex | Sodium/calcium exchanger protein | 5.9E-14 | 140 | 257 |
| PF01699 | Na_Ca_ex | Sodium/calcium exchanger protein | 7.1E-19 | 591 | 733 |
| Swissprot ID | Swissprot Description | Start | End | E-value |
|---|---|---|---|---|
| sp|Q99385|VCX1_YEAST | Vacuolar calcium ion transporter OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=VCX1 PE=1 SV=1 | 572 | 746 | 3.0E-51 |
| sp|O59768|VCX1_SCHPO | Vacuolar calcium ion transporter OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=vcx1 PE=3 SV=1 | 572 | 736 | 1.0E-44 |
| sp|Q75XW3|CAX_APHHA | Ca(2+)/H(+) antiporter OS=Aphanothece halophytica PE=1 SV=1 | 593 | 740 | 1.0E-37 |
| sp|Q8L783|CAX5_ARATH | Vacuolar cation/proton exchanger 5 OS=Arabidopsis thaliana GN=CAX5 PE=2 SV=1 | 579 | 738 | 6.0E-36 |
| sp|Q39254|CAX2_ARATH | Vacuolar cation/proton exchanger 2 OS=Arabidopsis thaliana GN=CAX2 PE=1 SV=2 | 579 | 738 | 3.0E-35 |
| Swissprot ID | Swissprot Description | Start | End | E-value |
|---|---|---|---|---|
| sp|Q99385|VCX1_YEAST | Vacuolar calcium ion transporter OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=VCX1 PE=1 SV=1 | 572 | 746 | 3.0E-51 |
| sp|O59768|VCX1_SCHPO | Vacuolar calcium ion transporter OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=vcx1 PE=3 SV=1 | 572 | 736 | 1.0E-44 |
| sp|Q75XW3|CAX_APHHA | Ca(2+)/H(+) antiporter OS=Aphanothece halophytica PE=1 SV=1 | 593 | 740 | 1.0E-37 |
| sp|Q8L783|CAX5_ARATH | Vacuolar cation/proton exchanger 5 OS=Arabidopsis thaliana GN=CAX5 PE=2 SV=1 | 579 | 738 | 6.0E-36 |
| sp|Q39254|CAX2_ARATH | Vacuolar cation/proton exchanger 2 OS=Arabidopsis thaliana GN=CAX2 PE=1 SV=2 | 579 | 738 | 3.0E-35 |
| sp|P74072|CAX_SYNY3 | Ca(2+)/H(+) antiporter OS=Synechocystis sp. (strain PCC 6803 / Kazusa) GN=slr1336 PE=1 SV=1 | 592 | 737 | 6.0E-34 |
| sp|Q6K1C4|CAX3_ORYSJ | Vacuolar cation/proton exchanger 3 OS=Oryza sativa subsp. japonica GN=CAX3 PE=2 SV=2 | 594 | 742 | 2.0E-33 |
| sp|Q769E5|CAX1A_ORYSJ | Vacuolar cation/proton exchanger 1a OS=Oryza sativa subsp. japonica GN=CAX1a PE=1 SV=1 | 581 | 739 | 2.0E-33 |
| sp|Q6YXZ1|CAX4_ORYSJ | Putative vacuolar cation/proton exchanger 4 OS=Oryza sativa subsp. japonica GN=Os02g0138900 PE=3 SV=1 | 574 | 729 | 9.0E-33 |
| sp|Q5KQN0|CAX2_ORYSJ | Vacuolar cation/proton exchanger 2 OS=Oryza sativa subsp. japonica GN=CAX2 PE=2 SV=2 | 585 | 742 | 2.0E-32 |
| sp|Q9LFZ8|CAX6_ARATH | Putative vacuolar cation/proton exchanger 6 OS=Arabidopsis thaliana GN=CAX6 PE=3 SV=3 | 578 | 738 | 4.0E-32 |
| sp|Q945S5|CAX4_ARATH | Vacuolar cation/proton exchanger 4 OS=Arabidopsis thaliana GN=CAX4 PE=1 SV=2 | 574 | 742 | 6.0E-31 |
| sp|Q93Z81|CAX3_ARATH | Vacuolar cation/proton exchanger 3 OS=Arabidopsis thaliana GN=CAX3 PE=1 SV=1 | 576 | 735 | 1.0E-28 |
| sp|Q39253|CAX1_ARATH | Vacuolar cation/proton exchanger 1 OS=Arabidopsis thaliana GN=CAX1 PE=1 SV=3 | 579 | 733 | 2.0E-27 |
| sp|Q5TKG3|CAX1B_ORYSJ | Vacuolar cation/proton exchanger 1b OS=Oryza sativa subsp. japonica GN=CAX1b PE=2 SV=1 | 577 | 733 | 1.0E-26 |
| sp|O34840|CHAA_BACSU | Ca(2+)/H(+) antiporter ChaA OS=Bacillus subtilis (strain 168) GN=chaA PE=1 SV=1 | 571 | 734 | 3.0E-24 |
| sp|O59768|VCX1_SCHPO | Vacuolar calcium ion transporter OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=vcx1 PE=3 SV=1 | 100 | 263 | 3.0E-23 |
| sp|Q5KQN0|CAX2_ORYSJ | Vacuolar cation/proton exchanger 2 OS=Oryza sativa subsp. japonica GN=CAX2 PE=2 SV=2 | 102 | 265 | 6.0E-22 |
| sp|Q39254|CAX2_ARATH | Vacuolar cation/proton exchanger 2 OS=Arabidopsis thaliana GN=CAX2 PE=1 SV=2 | 48 | 264 | 1.0E-21 |
| sp|Q9LFZ8|CAX6_ARATH | Putative vacuolar cation/proton exchanger 6 OS=Arabidopsis thaliana GN=CAX6 PE=3 SV=3 | 91 | 270 | 2.0E-21 |
| sp|Q5KTQ9|CAX1C_ORYSJ | Vacuolar cation/proton exchanger 1c OS=Oryza sativa subsp. japonica GN=CAX1c PE=2 SV=1 | 589 | 733 | 6.0E-21 |
| sp|Q99385|VCX1_YEAST | Vacuolar calcium ion transporter OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=VCX1 PE=1 SV=1 | 102 | 265 | 9.0E-21 |
| sp|Q6K1C4|CAX3_ORYSJ | Vacuolar cation/proton exchanger 3 OS=Oryza sativa subsp. japonica GN=CAX3 PE=2 SV=2 | 84 | 262 | 2.0E-20 |
| sp|Q8L783|CAX5_ARATH | Vacuolar cation/proton exchanger 5 OS=Arabidopsis thaliana GN=CAX5 PE=2 SV=1 | 91 | 302 | 3.0E-20 |
| sp|Q75XW3|CAX_APHHA | Ca(2+)/H(+) antiporter OS=Aphanothece halophytica PE=1 SV=1 | 105 | 265 | 4.0E-20 |
| sp|P74072|CAX_SYNY3 | Ca(2+)/H(+) antiporter OS=Synechocystis sp. (strain PCC 6803 / Kazusa) GN=slr1336 PE=1 SV=1 | 104 | 265 | 2.0E-18 |
| sp|Q6YXZ1|CAX4_ORYSJ | Putative vacuolar cation/proton exchanger 4 OS=Oryza sativa subsp. japonica GN=Os02g0138900 PE=3 SV=1 | 92 | 268 | 7.0E-18 |
| sp|P42839|VNX1_YEAST | Low affinity vacuolar monovalent cation/H(+) antiporter OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=VNX1 PE=1 SV=1 | 573 | 735 | 3.0E-16 |
| sp|Q5TKG3|CAX1B_ORYSJ | Vacuolar cation/proton exchanger 1b OS=Oryza sativa subsp. japonica GN=CAX1b PE=2 SV=1 | 126 | 271 | 2.0E-13 |
| sp|Q93Z81|CAX3_ARATH | Vacuolar cation/proton exchanger 3 OS=Arabidopsis thaliana GN=CAX3 PE=1 SV=1 | 34 | 265 | 5.0E-13 |
| sp|Q9P7B3|YI14_SCHPO | Putative cation exchanger C521.04c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC521.04c PE=1 SV=1 | 580 | 735 | 1.0E-12 |
| sp|Q39253|CAX1_ARATH | Vacuolar cation/proton exchanger 1 OS=Arabidopsis thaliana GN=CAX1 PE=1 SV=3 | 114 | 270 | 1.0E-11 |
| sp|O34840|CHAA_BACSU | Ca(2+)/H(+) antiporter ChaA OS=Bacillus subtilis (strain 168) GN=chaA PE=1 SV=1 | 125 | 265 | 2.0E-11 |
| sp|Q945S5|CAX4_ARATH | Vacuolar cation/proton exchanger 4 OS=Arabidopsis thaliana GN=CAX4 PE=1 SV=2 | 55 | 257 | 4.0E-10 |
| sp|Q769E5|CAX1A_ORYSJ | Vacuolar cation/proton exchanger 1a OS=Oryza sativa subsp. japonica GN=CAX1a PE=1 SV=1 | 126 | 271 | 2.0E-07 |
| sp|P42839|VNX1_YEAST | Low affinity vacuolar monovalent cation/H(+) antiporter OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=VNX1 PE=1 SV=1 | 153 | 319 | 7.0E-06 |
| GO Term | Description | Terminal node |
|---|---|---|
| GO:0016021 | integral component of membrane | Yes |
| GO:0055085 | transmembrane transport | Yes |
| GO:0009987 | cellular process | No |
| GO:0051234 | establishment of localization | No |
| GO:0006810 | transport | No |
| GO:0110165 | cellular anatomical entity | No |
| GO:0031224 | intrinsic component of membrane | No |
| GO:0005575 | cellular_component | No |
| GO:0051179 | localization | No |
| GO:0008150 | biological_process | No |
| SignalP signal predicted | Location (based on Ymax) |
D score (significance: > 0.45) |
|---|---|---|
| No | 1 - 42 | 0.45 |
| Domain # | Start | End | Length |
|---|---|---|---|
| 1 | 94 | 116 | 22 |
| 2 | 123 | 145 | 22 |
| 3 | 165 | 187 | 22 |
| 4 | 200 | 222 | 22 |
| 5 | 237 | 255 | 18 |
| 6 | 588 | 610 | 22 |
| 7 | 625 | 647 | 22 |
| 8 | 654 | 676 | 22 |
| 9 | 686 | 708 | 22 |
| 10 | 715 | 737 | 22 |
Expression values
| Label | Description | Expression (RPKM) | Confidence interval (low) | Confidence interval (high) |
|---|---|---|---|---|
| SC16a | Pure fungal culture | 151.10 | 73.45 | 228.76 |
| CcL | In ants, during behavior modification | 11.04 | 4.75 | 17.32 |
| CcD | In ants, recently dead | 27.35 | 14.60 | 40.09 |
Differential expression
| Label1 | Label2 | Q-value | Significant difference |
|---|---|---|---|
| SC16a | CcL | 0.000286 | yes |
| SC16a | CcD | 0.000286 | yes |
| CcL | CcD | 0.000286 | yes |
| Type of sequence | Sequence |
|---|---|
| Locus | Download genbank file of locus
The gene with 5 kb flanks (if sufficient flanking sequence is available). For use in cloning design programs. NOTE: features (genes or exons) that are only partially contained within the sequence are completely excluded. |
| Protein | >Ophio5|4573 MKESPSDPPDIVVVNARRHNHDYDDDDDDDDVLQGSLVTPPDEKPAAAASDMTTPGAEQQQQQQQQQQQQQKTKD KDKNKLSTRFVQELRRSFHMVATYSWLNVLLLFVPIGIIVANVKGIHGGIVFAMNCIAIVPLAGLLSYATDLSSS CNIALVKDQIRIVQASLLGSILANLLLILGMGFFLGGLRYREQVYNSTVTQVSACLLSLSVISLMLPTAFHASFN DPSRADEESLKISRGTSVILLLVYVIYLLFQLKSHAYMYESTPQHIVDAEAIPGPAAAWLDTSSSSDNCSTASDD SDDSDRSRDTMRRKMKKVLRGGRRRKSSIASTDTGDTGGIRNGSLVIANGSAVDERASEVSLKRPVPLFREASDE TVEDAVEDEKPRKRGGKRHHRLHRHHRRRHGKHRHDAREQSRAVINDASHVGSAAGEPRRVDFALQTGGGINPGT AAPTAAAAAAAAAAAATAAAATTASSSPGPKRPFPAFRGVSVKSLTPTVFAQRPELVEASPQVRAGPVPRVRYGI RRTNSLPDRLRNQPHGRAPGAMFPAHGVRSSMTGSGSGGVGGGLGPHPDAEGQDEEAPHLSRTAAVILLLLTTGL VAVCAEFLVGSIEAVTRTSTIGEIFIGLIILPIVGNAAEHVTAITVAMKNKMDLAIGVAVGSSIQIALFVTPLVV ILGWIIGREMTLFFTLFETVSLFASAFIVNFLVLDGRSNYLEGALLCAVYVIIAIVAFFFPTEQETSTWGN |
| Coding | >Ophio5|4573 ATGAAGGAAAGCCCTTCGGATCCGCCTGACATAGTCGTTGTTAACGCCCGCCGCCATAATCATGATTACGATGAT GATGATGATGATGATGATGTCCTCCAAGGCTCTTTGGTCACGCCCCCGGACGAGAAGCCGGCCGCTGCGGCTTCG GACATGACGACGCCGGGTGCCGAACAACAACAACAACAGCAGCAGCAGCAGCAGCAGCAGCAGAAGACCAAGGAC AAGGACAAGAACAAGCTGTCGACGAGATTCGTTCAAGAGCTTCGACGCTCGTTTCACATGGTTGCCACGTACAGC TGGCTCAACGTGCTGCTACTGTTTGTGCCCATCGGTATCATAGTCGCCAATGTCAAGGGAATTCATGGAGGCATC GTCTTCGCCATGAATTGCATCGCCATCGTTCCGCTCGCCGGCCTGCTCAGCTATGCTACCGACTTATCATCTTCA TGTAACATTGCTCTAGTCAAGGATCAAATCCGCATCGTTCAGGCCTCCCTGCTTGGCTCCATCTTGGCCAACCTC CTACTGATCCTCGGCATGGGCTTCTTCCTCGGCGGACTGCGATATCGCGAGCAGGTCTACAACAGCACCGTGACG CAGGTCAGCGCCTGTCTGCTCAGTCTGAGTGTCATCAGCCTCATGCTACCTACGGCCTTTCACGCCTCCTTCAAC GACCCCAGCCGCGCTGATGAGGAGTCTCTCAAAATCAGCCGCGGAACCAGTGTGATCCTCTTGCTCGTCTACGTC ATCTACTTGCTCTTCCAGCTCAAGTCGCACGCCTACATGTACGAGTCGACGCCTCAGCACATCGTCGACGCCGAG GCCATCCCCGGCCCCGCCGCGGCCTGGCTGGACACGTCGAGCTCCTCGGACAACTGCTCGACGGCCAGCGACGAC TCGGACGACTCGGACCGCTCTCGGGATACCATGAGGAGGAAGATGAAGAAGGTGTTGCGGGGCGGCCGGAGGCGC AAGTCGTCCATCGCGTCAACGGATACGGGCGACACGGGCGGCATCCGCAACGGTTCCTTGGTCATCGCCAACGGC AGCGCCGTGGACGAGCGGGCTTCCGAGGTGTCACTGAAGAGACCGGTGCCGTTGTTCCGCGAGGCGTCGGATGAG ACGGTAGAGGATGCCGTCGAAGACGAGAAGCCTCGCAAGCGAGGCGGGAAGAGGCATCATCGTCTCCATCGCCAT CATAGGCGTCGCCATGGAAAACATCGTCACGATGCGCGCGAGCAGTCGAGGGCCGTCATCAACGACGCGTCCCAC GTCGGCTCCGCGGCCGGAGAGCCGCGTCGGGTCGACTTTGCCCTCCAGACGGGCGGCGGCATCAACCCCGGCACG GCGGCCCCCACAGCCGCGGCCGCCGCAGCAGCAGCCGCCGCAGCAGCAACGGCGGCGGCGGCGACGACGGCCAGC TCGAGTCCCGGCCCGAAGAGACCATTCCCCGCCTTCCGTGGCGTGTCGGTCAAGAGCCTGACGCCGACCGTCTTC GCCCAGCGGCCCGAGTTGGTCGAGGCGTCGCCGCAGGTCCGGGCCGGGCCGGTGCCCCGCGTGCGGTACGGCATC CGACGGACCAACTCGCTCCCGGACCGACTGAGAAACCAGCCCCATGGGCGTGCTCCCGGGGCCATGTTCCCCGCC CACGGCGTGCGGTCGTCCATGACGGGAAGCGGCAGCGGAGGCGTCGGCGGAGGTCTCGGGCCGCACCCGGACGCC GAGGGCCAGGATGAAGAGGCGCCGCACCTTTCGCGCACGGCGGCCGTGATTCTCCTGCTGTTGACGACGGGCCTC GTGGCCGTCTGCGCCGAGTTCCTGGTCGGGTCGATCGAGGCGGTGACTCGGACGTCGACGATTGGCGAGATCTTC ATCGGCCTCATCATCCTGCCCATCGTCGGCAACGCGGCCGAGCACGTGACGGCCATCACGGTGGCCATGAAGAAC AAGATGGACCTGGCGATTGGGGTGGCGGTGGGCAGCTCGATCCAGATCGCGCTGTTCGTGACGCCGCTGGTGGTG ATACTGGGATGGATCATCGGGCGGGAGATGACGCTCTTCTTTACGCTGTTCGAGACGGTGAGCCTGTTCGCGTCG GCCTTTATCGTCAATTTCCTCGTCCTGGACGGACGCAGCAATTATCTCGAGGGGGCGCTGCTGTGTGCCGTCTAC GTCATCATTGCCATTGTTGCGTTTTTCTTTCCCACCGAGCAGGAGACGAGCACGTGGGGGAAC |
| Transcript | >Ophio5|4573 ATGAAGGAAAGCCCTTCGGATCCGCCTGACATAGTCGTTGTTAACGCCCGCCGCCATAATCATGATTACGATGAT GATGATGATGATGATGATGTCCTCCAAGGCTCTTTGGTCACGCCCCCGGACGAGAAGCCGGCCGCTGCGGCTTCG GACATGACGACGCCGGGTGCCGAACAACAACAACAACAGCAGCAGCAGCAGCAGCAGCAGCAGAAGACCAAGGAC AAGGACAAGAACAAGCTGTCGACGAGATTCGTTCAAGAGCTTCGACGCTCGTTTCACATGGTTGCCACGTACAGC TGGCTCAACGTGCTGCTACTGTTTGTGCCCATCGGTATCATAGTCGCCAATGTCAAGGGAATTCATGGAGGCATC GTCTTCGCCATGAATTGCATCGCCATCGTTCCGCTCGCCGGCCTGCTCAGCTATGCTACCGACTTATCATCTTCA TGTAACATTGCTCTAGTCAAGGATCAAATCCGCATCGTTCAGGCCTCCCTGCTTGGCTCCATCTTGGCCAACCTC CTACTGATCCTCGGCATGGGCTTCTTCCTCGGCGGACTGCGATATCGCGAGCAGGTCTACAACAGCACCGTGACG CAGGTCAGCGCCTGTCTGCTCAGTCTGAGTGTCATCAGCCTCATGCTACCTACGGCCTTTCACGCCTCCTTCAAC GACCCCAGCCGCGCTGATGAGGAGTCTCTCAAAATCAGCCGCGGAACCAGTGTGATCCTCTTGCTCGTCTACGTC ATCTACTTGCTCTTCCAGCTCAAGTCGCACGCCTACATGTACGAGTCGACGCCTCAGCACATCGTCGACGCCGAG GCCATCCCCGGCCCCGCCGCGGCCTGGCTGGACACGTCGAGCTCCTCGGACAACTGCTCGACGGCCAGCGACGAC TCGGACGACTCGGACCGCTCTCGGGATACCATGAGGAGGAAGATGAAGAAGGTGTTGCGGGGCGGCCGGAGGCGC AAGTCGTCCATCGCGTCAACGGATACGGGCGACACGGGCGGCATCCGCAACGGTTCCTTGGTCATCGCCAACGGC AGCGCCGTGGACGAGCGGGCTTCCGAGGTGTCACTGAAGAGACCGGTGCCGTTGTTCCGCGAGGCGTCGGATGAG ACGGTAGAGGATGCCGTCGAAGACGAGAAGCCTCGCAAGCGAGGCGGGAAGAGGCATCATCGTCTCCATCGCCAT CATAGGCGTCGCCATGGAAAACATCGTCACGATGCGCGCGAGCAGTCGAGGGCCGTCATCAACGACGCGTCCCAC GTCGGCTCCGCGGCCGGAGAGCCGCGTCGGGTCGACTTTGCCCTCCAGACGGGCGGCGGCATCAACCCCGGCACG GCGGCCCCCACAGCCGCGGCCGCCGCAGCAGCAGCCGCCGCAGCAGCAACGGCGGCGGCGGCGACGACGGCCAGC TCGAGTCCCGGCCCGAAGAGACCATTCCCCGCCTTCCGTGGCGTGTCGGTCAAGAGCCTGACGCCGACCGTCTTC GCCCAGCGGCCCGAGTTGGTCGAGGCGTCGCCGCAGGTCCGGGCCGGGCCGGTGCCCCGCGTGCGGTACGGCATC CGACGGACCAACTCGCTCCCGGACCGACTGAGAAACCAGCCCCATGGGCGTGCTCCCGGGGCCATGTTCCCCGCC CACGGCGTGCGGTCGTCCATGACGGGAAGCGGCAGCGGAGGCGTCGGCGGAGGTCTCGGGCCGCACCCGGACGCC GAGGGCCAGGATGAAGAGGCGCCGCACCTTTCGCGCACGGCGGCCGTGATTCTCCTGCTGTTGACGACGGGCCTC GTGGCCGTCTGCGCCGAGTTCCTGGTCGGGTCGATCGAGGCGGTGACTCGGACGTCGACGATTGGCGAGATCTTC ATCGGCCTCATCATCCTGCCCATCGTCGGCAACGCGGCCGAGCACGTGACGGCCATCACGGTGGCCATGAAGAAC AAGATGGACCTGGCGATTGGGGTGGCGGTGGGCAGCTCGATCCAGATCGCGCTGTTCGTGACGCCGCTGGTGGTG ATACTGGGATGGATCATCGGGCGGGAGATGACGCTCTTCTTTACGCTGTTCGAGACGGTGAGCCTGTTCGCGTCG GCCTTTATCGTCAATTTCCTCGTCCTGGACGGACGCAGCAATTATCTCGAGGGGGCGCTGCTGTGTGCCGTCTAC GTCATCATTGCCATTGTTGCGTTTTTCTTTCCCACCGAGCAGGAGACGAGCACGTGGGGGAACTAG |
| Gene | >Ophio5|4573 ATGAAGGAAAGCCCTTCGGATCCGCCTGACATAGTCGTTGTTAACGCCCGCCGCCATAATCATGATTACGATGAT GATGATGATGATGATGATGTCCTCCAAGGCTCTTTGGTCACGCCCCCGGACGAGAAGCCGGCCGCTGCGGCTTCG GACATGACGACGCCGGGTGCCGAACAACAACAACAACAGCAGCAGCAGCAGCAGCAGCAGCAGAAGACCAAGGAC AAGGACAAGAACAAGCTGTCGACGAGATTCGTTCAAGAGCTTCGACGCTCGTTTCACATGGTTGCCACGTACAGC TGGCTCAACGTGCTGCTACTGTTTGTGCCCATCGGTATCATAGTCGCCAATGTCAAGGGAATTCATGGAGGCATC GTCTTCGCCATGAATTGCATCGCCATCGTTCCGCTCGCCGGCCTGCTCAGCTATGCTACCGAGTCGGTTGCTAGC AATATGGGGGACTCGCTTGGCGCCTTGCTCAATGTTACCTTTGGCAATGCCGTCGAGCTTATCATCTTGTGGGTT GTCTTGCTTGCTTTGTTCTTGTGAGCTTGACGACTGACAACCGTGGCAGCATGTAAGTCGGGCTCACCGAAACCG CCGCCATCGAGACTCTCTCCTCCTACACTCCGTCTGTCCATTGCCTTTTGAGCTGACGGAGCCGACCCCTGCAGC ATTGCTCTAGTCAAGGTGCGTCATTCGCTTTCGGAACTCCCGACATGACTTCCGCTTACCAGAGAACCAGGATCA AATCCGCATCGTTCAGGCCTCCCTGCTTGGCTCCATCTTGGCCAACCTCCTACTGATCCTCGGCATGGGCTTCTT CCTCGGCGGACTGCGATATCGCGAGCAGGTGTGTGGCCTGGTGGCCGCAGACGCCAAGATGCTGATCTTTACAGG TCTACAACAGCACCGTGACGCAGGTCAGCGCCTGTCTGCTCAGTCTGAGTGTCATCAGCCTCATGCTACCTGTGA GACTCCTTGCTCCCGTCACGGCTACAAAACGAAGCACTGACACGCGGCCCAGACGGCCTTTCACGCCTCCTTCAA CGACCCCAGCCGCGCTGATGAGGAGTCTCTCAAAATCAGCCGCGGAACCAGTGTGGTGAGTGGCCACGTCTCTCT GCACACTGCCCCTCAGTTGACGCCGTATCCCCCCCCCGGGGCAGATCCTCTTGCTCGTCTACGTCATCTACTTGC TCTTCCAGCTCAAGTCGCACGCCTACATGTACGAGTCGACGCCTCAGCACATCGTCGACGCCGAGGCCATCCCCG GCCCCGCCGCGGCCTGGCTGGACACGTCGAGCTCCTCGGACAACTGCTCGACGGCCAGCGACGACTCGGACGACT CGGACCGCTCTCGGGATACCATGAGGAGGAAGATGAAGAAGGTGTTGCGGGGCGGCCGGAGGCGCAAGTCGTCCA TCGCGTCAACGGATACGGGCGACACGGGCGGCATCCGCAACGGTTCCTTGGTCATCGCCAACGGCAGCGCCGTGG ACGAGCGGGCTTCCGAGGTGTCACTGAAGAGACCGGTGCCGTTGTTCCGCGAGGCGTCGGATGAGACGGTAGAGG ATGCCGTCGAAGACGAGAAGCCTCGCAAGCGAGGCGGGAAGAGGCATCATCGTCTCCATCGCCATCATAGGCGTC GCCATGGAAAACATCGTCACGATGCGCGCGAGCAGTCGAGGGCCGTCATCAACGACGCGTCCCACGTCGGCTCCG CGGCCGGAGAGCCGCGTCGGGTCGACTTTGCCCTCCAGACGGGCGGCGGCATCAACCCCGGCACGGCGGCCCCCA CAGCCGCGGCCGCCGCAGCAGCAGCCGCCGCAGCAGCAACGGCGGCGGCGGCGACGACGGCCAGCTCGAGTCCCG GCCCGAAGAGACCATTCCCCGCCTTCCGTGGCGTGTCGGTCAAGAGCCTGACGCCGACCGTCTTCGCCCAGCGGC CCGAGTTGGTCGAGGCGTCGCCGCAGGTCCGGGCCGGGCCGGTGCCCCGCGTGCGGTACGGCATCCGACGGACCA ACTCGCTCCCGGACCGACTGAGAAACCAGCCCCATGGGCGTGCTCCCGGGGCCATGTTCCCCGCCCACGGCGTGC GGTCGTCCATGACGGGAAGCGGCAGCGGAGGCGTCGGCGGAGGTCTCGGGCCGCACCCGGACGCCGAGGGCCAGG ATGAAGAGGCGCCGCACCTTTCGCGCACGGCGGCCGTGATTCTCCTGCTGTTGACGACGGGCCTCGTGGCCGTCT GCGCCGAGTTCCTGGTCGGGTCGATCGAGGCGGTGACTCGGACGTCGACGATTGGCGAGATCTTCATCGGCCTCA TCATCCTGCCCATCGTCGGCAACGCGGCCGAGCACGTGACGGCCATCACGGTGGCCATGAAGAACAAGATGGACC TGGCGATTGGGGTGGCGGTGGGCAGCTCGATCCAGATCGCGCTGTTCGTGACGCCGCTGGTGGTGATACTGGGAT GGATCATCGGGCGGGAGATGACGCTCTTCTTTACGCTGTTCGAGACGGTGAGCCTGTTCGCGTCGGCCTTTATCG TCAATTTCCTCGTCCTGGACGGACGCAGCAATTATCTCGAGGGGGCGCTGCTGTGTGCCGTCTACGTCATCATTG CCATTGTTGCGTTTTTCTTTCCCACCGAGCAGGAGACGAGCACGTGGGGGAACTAG |