© 2022 - Robin Ohm - Utrecht University - The Netherlands
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| Protein ID | Ophio5|1749 |
| Gene name | |
| Location | scaffold_166:8654..10988 |
| Strand | + |
| Gene length (bp) | 2334 |
| Transcript length (bp) | 2160 |
| Coding sequence length (bp) | 2157 |
| Protein length (aa) | 719 |
| PFAM Domain ID | Short name | Long name | E-value | Start | End |
|---|---|---|---|---|---|
| PF00172 | Zn_clus | Fungal Zn(2)-Cys(6) binuclear cluster domain | 5.1E-09 | 161 | 203 |
| Swissprot ID | Swissprot Description | Start | End | E-value |
|---|---|---|---|---|
| sp|O59780|YCN3_SCHPO | Uncharacterized transcriptional regulatory protein C320.03 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPCC320.03 PE=3 SV=1 | 318 | 653 | 5.0E-22 |
| sp|Q750N3|RGT1_ASHGO | Glucose transport transcription regulator RGT1 OS=Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) GN=RGT1 PE=3 SV=1 | 154 | 211 | 1.0E-15 |
| sp|A6ZZS7|RGT1_YEAS7 | Glucose transport transcription regulator RGT1 OS=Saccharomyces cerevisiae (strain YJM789) GN=RGT1 PE=3 SV=1 | 154 | 229 | 1.0E-15 |
| sp|P32862|RGT1_YEAST | Glucose transport transcription regulator RGT1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RGT1 PE=1 SV=1 | 154 | 229 | 1.0E-15 |
| sp|B3LR49|RGT1_YEAS1 | Glucose transport transcription regulator RGT1 OS=Saccharomyces cerevisiae (strain RM11-1a) GN=RGT1 PE=3 SV=1 | 154 | 229 | 1.0E-15 |
| Swissprot ID | Swissprot Description | Start | End | E-value |
|---|---|---|---|---|
| sp|O59780|YCN3_SCHPO | Uncharacterized transcriptional regulatory protein C320.03 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPCC320.03 PE=3 SV=1 | 318 | 653 | 5.0E-22 |
| sp|Q750N3|RGT1_ASHGO | Glucose transport transcription regulator RGT1 OS=Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) GN=RGT1 PE=3 SV=1 | 154 | 211 | 1.0E-15 |
| sp|A6ZZS7|RGT1_YEAS7 | Glucose transport transcription regulator RGT1 OS=Saccharomyces cerevisiae (strain YJM789) GN=RGT1 PE=3 SV=1 | 154 | 229 | 1.0E-15 |
| sp|P32862|RGT1_YEAST | Glucose transport transcription regulator RGT1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RGT1 PE=1 SV=1 | 154 | 229 | 1.0E-15 |
| sp|B3LR49|RGT1_YEAS1 | Glucose transport transcription regulator RGT1 OS=Saccharomyces cerevisiae (strain RM11-1a) GN=RGT1 PE=3 SV=1 | 154 | 229 | 1.0E-15 |
| sp|C7GP35|RGT1_YEAS2 | Glucose transport transcription regulator RGT1 OS=Saccharomyces cerevisiae (strain JAY291) GN=RGT1 PE=3 SV=1 | 154 | 229 | 1.0E-15 |
| sp|Q6FLP2|RGT1_CANGA | Glucose transport transcription regulator RGT1 OS=Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) GN=RGT1 PE=3 SV=1 | 154 | 208 | 4.0E-15 |
| sp|Q6CIL8|RGT1_KLULA | Glucose transport transcription regulator RGT1 OS=Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) GN=RGT1 PE=3 SV=1 | 154 | 211 | 6.0E-14 |
| sp|A7TE38|RGT1_VANPO | Glucose transport transcription regulator RGT1 OS=Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) GN=RGT1 PE=3 SV=1 | 158 | 209 | 9.0E-13 |
| sp|C5DGQ7|RGT1_LACTC | Glucose transport transcription regulator RGT1 OS=Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) GN=RGT1 PE=3 SV=1 | 154 | 211 | 1.0E-12 |
| sp|C5E4G1|RGT1_ZYGRC | Glucose transport transcription regulator RGT1 OS=Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229) GN=RGT1 PE=3 SV=1 | 154 | 231 | 1.0E-12 |
| sp|O59780|YCN3_SCHPO | Uncharacterized transcriptional regulatory protein C320.03 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPCC320.03 PE=3 SV=1 | 154 | 209 | 6.0E-11 |
| sp|P87000|ACU15_NEUCR | Transcriptional activator protein acu-15 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=acu-15 PE=1 SV=2 | 156 | 584 | 8.0E-11 |
| sp|O59741|YN25_SCHPO | Uncharacterized transcriptional regulatory protein C530.05 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPBC530.05 PE=3 SV=2 | 143 | 518 | 1.0E-10 |
| sp|P36598|THI1_SCHPO | Thiamine repressible genes regulatory protein thi1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=thi1 PE=1 SV=2 | 151 | 221 | 4.0E-10 |
| sp|C7GXX9|EDS1_YEAS2 | Transcriptional regulatory protein EDS1 OS=Saccharomyces cerevisiae (strain JAY291) GN=EDS1 PE=3 SV=1 | 154 | 207 | 2.0E-08 |
| sp|D3UEC9|EDS1_YEAS8 | Transcriptional regulatory protein EDS1 OS=Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse) GN=EDS1 PE=3 SV=1 | 154 | 207 | 2.0E-08 |
| sp|A6ZKX7|EDS1_YEAS7 | Transcriptional regulatory protein EDS1 OS=Saccharomyces cerevisiae (strain YJM789) GN=EDS1 PE=3 SV=1 | 154 | 207 | 2.0E-08 |
| sp|B5VDZ9|EDS1_YEAS6 | Transcriptional regulatory protein EDS1 OS=Saccharomyces cerevisiae (strain AWRI1631) GN=EDS1 PE=3 SV=1 | 154 | 207 | 2.0E-08 |
| sp|B3LNB2|EDS1_YEAS1 | Transcriptional regulatory protein EDS1 OS=Saccharomyces cerevisiae (strain RM11-1a) GN=EDS1 PE=3 SV=1 | 154 | 207 | 2.0E-08 |
| sp|P10563|QUTA_EMENI | Quinic acid utilization activator OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) GN=qutA PE=3 SV=2 | 141 | 225 | 2.0E-08 |
| sp|P38073|EDS1_YEAST | Transcriptional regulatory protein EDS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=EDS1 PE=1 SV=1 | 154 | 267 | 1.0E-07 |
| sp|O94278|THI5_SCHPO | Thiamine repressible genes regulatory protein thi5 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=thi5 PE=3 SV=1 | 136 | 225 | 1.0E-07 |
| sp|P40467|ASG1_YEAST | Activator of stress genes 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ASG1 PE=1 SV=1 | 155 | 208 | 2.0E-07 |
| sp|A1DIC0|XLNR_NEOFI | Xylanolytic transcriptional activator xlnR OS=Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) GN=xlnR PE=3 SV=2 | 76 | 234 | 4.0E-07 |
| sp|P11638|QA1F_NEUCR | Quinic acid utilization activator OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=qa-1f PE=3 SV=2 | 155 | 274 | 2.0E-06 |
| sp|Q2UD93|XLNR_ASPOR | Xylanolytic transcriptional activator xlnR OS=Aspergillus oryzae (strain ATCC 42149 / RIB 40) GN=xlnR PE=1 SV=2 | 156 | 235 | 2.0E-06 |
| sp|B8N6M6|XLNR_ASPFN | Xylanolytic transcriptional activator xlnR OS=Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167) GN=xlnR PE=3 SV=1 | 156 | 235 | 2.0E-06 |
| sp|Q5AVS0|XLNR_EMENI | Xylanolytic transcriptional activator xlnR OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) GN=xlnR PE=2 SV=2 | 156 | 204 | 1.0E-05 |
| GO Term | Description | Terminal node |
|---|---|---|
| GO:0006355 | regulation of transcription, DNA-templated | Yes |
| GO:0008270 | zinc ion binding | Yes |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | Yes |
| GO:0008150 | biological_process | No |
| GO:0051252 | regulation of RNA metabolic process | No |
| GO:0060255 | regulation of macromolecule metabolic process | No |
| GO:0019222 | regulation of metabolic process | No |
| GO:0050794 | regulation of cellular process | No |
| GO:0140110 | transcription regulator activity | No |
| GO:0031323 | regulation of cellular metabolic process | No |
| GO:0065007 | biological regulation | No |
| GO:0046872 | metal ion binding | No |
| GO:0010468 | regulation of gene expression | No |
| GO:0043167 | ion binding | No |
| GO:0043169 | cation binding | No |
| GO:0003674 | molecular_function | No |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | No |
| GO:0051171 | regulation of nitrogen compound metabolic process | No |
| GO:0005488 | binding | No |
| GO:0080090 | regulation of primary metabolic process | No |
| GO:0009889 | regulation of biosynthetic process | No |
| GO:0050789 | regulation of biological process | No |
| GO:0003700 | DNA-binding transcription factor activity | No |
| GO:1903506 | regulation of nucleic acid-templated transcription | No |
| GO:2001141 | regulation of RNA biosynthetic process | No |
| GO:0046914 | transition metal ion binding | No |
| GO:0010556 | regulation of macromolecule biosynthetic process | No |
| GO:0031326 | regulation of cellular biosynthetic process | No |
| SignalP signal predicted | Location (based on Ymax) |
D score (significance: > 0.45) |
|---|---|---|
| No | 1 - 47 | 0.45 |
| Transcription Factor Class (based on PFAM domains) |
|---|
| Fungal Specific TF |
Expression values
| Label | Description | Expression (RPKM) | Confidence interval (low) | Confidence interval (high) |
|---|---|---|---|---|
| SC16a | Pure fungal culture | 105.78 | 54.62 | 156.95 |
| CcL | In ants, during behavior modification | 98.07 | 49.78 | 146.37 |
| CcD | In ants, recently dead | 91.91 | 47.96 | 135.86 |
Differential expression
| Label1 | Label2 | Q-value | Significant difference |
|---|---|---|---|
| SC16a | CcL | 0.795065 | no |
| SC16a | CcD | 0.603067 | no |
| CcL | CcD | 0.831673 | no |
| Type of sequence | Sequence |
|---|---|
| Locus | Download genbank file of locus
The gene with 5 kb flanks (if sufficient flanking sequence is available). For use in cloning design programs. NOTE: features (genes or exons) that are only partially contained within the sequence are completely excluded. |
| Protein | >Ophio5|1749 MSPSRQGESEEAPGLHYPSPTTEAMDAGPFYHSNARDGPPEHADHPEQHGQQDVAQDQGQMPPPDSPQHVSRPPN LEELQLAAQLGDGLAGNPMIPATDPNMNVDEHGMRSIMPHPEPEHHQASPYVHDASTADHMALPVGPPQYQINDG IPPRKRSKVSRACDECRRKKIKCDAQSDSGENPCSSCARSSIRCLFSRVPQKRGPSKGYIKELADRIHSIENKLE SEGNLTQDDIDKLFASDRPRSHDQVTPGDDLSRKRPYSSISTGDVNTPVATRQAPWGSEVRPSASSEGFSHEGYA NSALAPQPSAMKPEVIPSKPPVASMDASMADVDEVLDVDEEALKEYLTTMQPAFPILPSTIWRMQSLLSQCPSSL REAFRIALVTAAQQGTAGDVKHADALLREWENSDVPSSRASDMVHAQTLLLLSIDADRRELPTLSSLLARAVALA NSMKLWKLVTVDATDGDSDDALLLKIWWSLILMDRWHAAGTGKPVLIPDSSVVAMAGLAAVVGEICFYLTRLSKV LVKIANVLSGMPVGATAADANMATMLRDYVEDYREDLPAHVDVTSYPLVHLAYWHCRLLATLLTPGATALEMMWP ARELSGLLLADGQQRSPLTHHFASLAALCLTKLSKTDKTREEATQLIHDMVEAAPEGQWDGVQAWLAEHMRPPSS AEATASQGLQHLADLATAHEGMTAADGEVVAFGPALAAGYLGVQ |
| Coding | >Ophio5|1749 ATGAGCCCGAGCAGGCAGGGCGAGTCTGAAGAGGCTCCCGGCCTTCACTACCCGTCGCCAACCACCGAAGCCATG GACGCGGGGCCGTTTTACCACTCCAACGCCCGCGACGGCCCGCCGGAGCACGCAGACCACCCCGAGCAGCACGGT CAGCAGGATGTGGCCCAAGACCAGGGCCAGATGCCGCCACCGGACTCGCCGCAACATGTTTCGCGCCCGCCCAAT CTGGAAGAGCTGCAGCTTGCCGCTCAGCTTGGCGATGGCCTGGCCGGAAACCCCATGATACCGGCTACGGATCCC AATATGAACGTTGACGAGCACGGCATGCGCAGCATCATGCCTCATCCCGAGCCCGAGCACCACCAGGCCTCCCCA TATGTGCACGACGCGTCGACTGCAGACCATATGGCTCTGCCCGTGGGTCCGCCTCAGTATCAGATCAACGACGGC ATCCCGCCGCGGAAACGTTCCAAGGTGTCCCGTGCCTGCGATGAGTGCCGACGCAAGAAAATCAAGTGTGACGCA CAGTCCGATTCTGGCGAGAATCCATGTTCCAGCTGCGCGCGGTCGTCTATTCGCTGCTTGTTCAGCCGGGTGCCC CAAAAGCGAGGTCCTAGTAAGGGGTATATCAAGGAACTCGCAGACAGGATCCATAGCATCGAGAATAAGCTCGAG TCGGAAGGTAACTTGACGCAAGACGACATCGATAAGCTATTCGCCTCCGACCGTCCTCGAAGCCATGACCAGGTC ACGCCAGGCGATGATCTGAGCCGGAAACGGCCGTATTCAAGCATATCGACAGGCGATGTCAACACTCCGGTGGCG ACTCGGCAGGCACCCTGGGGCTCGGAAGTTCGACCATCAGCTTCGTCCGAGGGCTTCTCCCATGAAGGGTATGCG AACAGCGCTCTGGCGCCGCAGCCGTCGGCGATGAAGCCCGAAGTAATTCCGTCGAAGCCGCCTGTGGCCTCGATG GATGCCTCCATGGCCGACGTCGACGAAGTGCTCGACGTTGACGAGGAGGCCCTGAAGGAGTACCTGACGACGATG CAACCTGCGTTTCCGATCCTACCCAGCACCATTTGGCGCATGCAGTCGCTGCTGTCACAGTGCCCGTCGTCTCTC CGGGAAGCGTTCCGCATCGCACTCGTGACGGCGGCGCAACAAGGCACTGCGGGCGATGTCAAGCATGCTGACGCC CTCTTACGTGAGTGGGAGAACAGTGATGTGCCGAGCAGCCGGGCGTCGGACATGGTGCACGCCCAGACGCTCTTG CTACTCAGCATAGATGCCGACCGGCGAGAACTTCCGACGCTGTCGTCATTGCTGGCGCGGGCGGTGGCGCTGGCA AATAGTATGAAGCTCTGGAAGCTCGTGACGGTGGACGCAACAGACGGGGACTCGGACGATGCCCTGTTGCTCAAG ATCTGGTGGTCGCTGATCCTGATGGACCGCTGGCACGCGGCAGGGACGGGAAAGCCGGTGTTGATTCCCGACAGC AGTGTTGTGGCGATGGCCGGCCTGGCAGCGGTCGTGGGCGAGATCTGCTTCTATCTAACGAGACTATCCAAGGTT CTCGTCAAGATTGCAAACGTGCTGTCAGGCATGCCAGTCGGAGCGACGGCGGCAGACGCGAACATGGCGACAATG CTGAGAGACTACGTGGAGGACTACAGGGAAGATCTTCCGGCGCACGTGGATGTGACATCGTACCCGCTGGTGCAT CTGGCATACTGGCATTGCCGGCTACTGGCGACGCTGTTGACGCCGGGAGCGACGGCGCTGGAGATGATGTGGCCA GCGCGGGAGCTCAGTGGTCTGCTGCTGGCGGATGGGCAGCAGCGGAGCCCGCTAACGCACCACTTCGCGTCGTTG GCGGCGCTGTGCCTGACGAAACTGTCCAAGACGGACAAGACGCGCGAGGAGGCGACGCAGCTCATTCACGACATG GTGGAGGCGGCGCCGGAGGGCCAGTGGGACGGGGTGCAGGCATGGCTGGCTGAGCATATGCGACCGCCGTCGTCT GCGGAGGCGACGGCCAGCCAAGGACTGCAGCATCTGGCGGACCTGGCGACGGCGCACGAGGGCATGACGGCAGCC GACGGCGAGGTGGTTGCCTTTGGGCCGGCCCTGGCGGCGGGCTACTTGGGCGTGCAG |
| Transcript | >Ophio5|1749 ATGAGCCCGAGCAGGCAGGGCGAGTCTGAAGAGGCTCCCGGCCTTCACTACCCGTCGCCAACCACCGAAGCCATG GACGCGGGGCCGTTTTACCACTCCAACGCCCGCGACGGCCCGCCGGAGCACGCAGACCACCCCGAGCAGCACGGT CAGCAGGATGTGGCCCAAGACCAGGGCCAGATGCCGCCACCGGACTCGCCGCAACATGTTTCGCGCCCGCCCAAT CTGGAAGAGCTGCAGCTTGCCGCTCAGCTTGGCGATGGCCTGGCCGGAAACCCCATGATACCGGCTACGGATCCC AATATGAACGTTGACGAGCACGGCATGCGCAGCATCATGCCTCATCCCGAGCCCGAGCACCACCAGGCCTCCCCA TATGTGCACGACGCGTCGACTGCAGACCATATGGCTCTGCCCGTGGGTCCGCCTCAGTATCAGATCAACGACGGC ATCCCGCCGCGGAAACGTTCCAAGGTGTCCCGTGCCTGCGATGAGTGCCGACGCAAGAAAATCAAGTGTGACGCA CAGTCCGATTCTGGCGAGAATCCATGTTCCAGCTGCGCGCGGTCGTCTATTCGCTGCTTGTTCAGCCGGGTGCCC CAAAAGCGAGGTCCTAGTAAGGGGTATATCAAGGAACTCGCAGACAGGATCCATAGCATCGAGAATAAGCTCGAG TCGGAAGGTAACTTGACGCAAGACGACATCGATAAGCTATTCGCCTCCGACCGTCCTCGAAGCCATGACCAGGTC ACGCCAGGCGATGATCTGAGCCGGAAACGGCCGTATTCAAGCATATCGACAGGCGATGTCAACACTCCGGTGGCG ACTCGGCAGGCACCCTGGGGCTCGGAAGTTCGACCATCAGCTTCGTCCGAGGGCTTCTCCCATGAAGGGTATGCG AACAGCGCTCTGGCGCCGCAGCCGTCGGCGATGAAGCCCGAAGTAATTCCGTCGAAGCCGCCTGTGGCCTCGATG GATGCCTCCATGGCCGACGTCGACGAAGTGCTCGACGTTGACGAGGAGGCCCTGAAGGAGTACCTGACGACGATG CAACCTGCGTTTCCGATCCTACCCAGCACCATTTGGCGCATGCAGTCGCTGCTGTCACAGTGCCCGTCGTCTCTC CGGGAAGCGTTCCGCATCGCACTCGTGACGGCGGCGCAACAAGGCACTGCGGGCGATGTCAAGCATGCTGACGCC CTCTTACGTGAGTGGGAGAACAGTGATGTGCCGAGCAGCCGGGCGTCGGACATGGTGCACGCCCAGACGCTCTTG CTACTCAGCATAGATGCCGACCGGCGAGAACTTCCGACGCTGTCGTCATTGCTGGCGCGGGCGGTGGCGCTGGCA AATAGTATGAAGCTCTGGAAGCTCGTGACGGTGGACGCAACAGACGGGGACTCGGACGATGCCCTGTTGCTCAAG ATCTGGTGGTCGCTGATCCTGATGGACCGCTGGCACGCGGCAGGGACGGGAAAGCCGGTGTTGATTCCCGACAGC AGTGTTGTGGCGATGGCCGGCCTGGCAGCGGTCGTGGGCGAGATCTGCTTCTATCTAACGAGACTATCCAAGGTT CTCGTCAAGATTGCAAACGTGCTGTCAGGCATGCCAGTCGGAGCGACGGCGGCAGACGCGAACATGGCGACAATG CTGAGAGACTACGTGGAGGACTACAGGGAAGATCTTCCGGCGCACGTGGATGTGACATCGTACCCGCTGGTGCAT CTGGCATACTGGCATTGCCGGCTACTGGCGACGCTGTTGACGCCGGGAGCGACGGCGCTGGAGATGATGTGGCCA GCGCGGGAGCTCAGTGGTCTGCTGCTGGCGGATGGGCAGCAGCGGAGCCCGCTAACGCACCACTTCGCGTCGTTG GCGGCGCTGTGCCTGACGAAACTGTCCAAGACGGACAAGACGCGCGAGGAGGCGACGCAGCTCATTCACGACATG GTGGAGGCGGCGCCGGAGGGCCAGTGGGACGGGGTGCAGGCATGGCTGGCTGAGCATATGCGACCGCCGTCGTCT GCGGAGGCGACGGCCAGCCAAGGACTGCAGCATCTGGCGGACCTGGCGACGGCGCACGAGGGCATGACGGCAGCC GACGGCGAGGTGGTTGCCTTTGGGCCGGCCCTGGCGGCGGGCTACTTGGGCGTGCAGTGA |
| Gene | >Ophio5|1749 ATGAGCCCGAGCAGGCAGGGCGAGTCTGAAGAGGCTCCCGGCCTTCACTACCCGTCGCCAACCACCGAAGCCATG GACGCGGGGCCGTTTTACCACTCCAACGCCCGCGACGGCCCGCCGGAGCACGCAGACCACCCCGAGCAGCACGGT CAGCAGGATGTGGCCCAAGACCAGGGCCAGATGCCGCCACCGGACTCGCCGCAACATGTTTCGCGCCCGCCCAAT CTGGAAGAGCTGCAGCTTGCCGCTCAGCTTGGCGATGGCCTGGCCGGAAACCCCATGATACCGGCTACGGATCCC AATATGAACGTTGACGAGCACGGCATGCGCAGCATCATGCCTCATCCCGAGCCCGAGCACCACCAGGCCTCCCCA TATGTGCACGACGCGTCGACTGCAGACCATATGGCTCTGCCCGTGGGTCCGCCTCAGTATCAGATCAACGACGGC ATCCCGCCGCGGAAACGTTCCAAGGTGTCCCGTGCCTGCGATGAGTGCCGACGCAAGAAAATCAAGTGTGACGCA CAGTCCGATTCTGGCGAGAATCCATGTTCCAGCTGCGCGCGGTCGTCTATTCGCTGCTTGTTCAGCCGGGTGCCC CAAAAGCGAGGTCCTAGTAAGGGGTAAAGGGTCTCCAATTCCGGCACGAACTGCGTTGCTGGCGGGCTAATCCGG CTGCAGGTATATCAAGGAACTCGCAGACAGGATCCATAGCATCGAGAATAAGCTCGAGTCGGAAGGTAACTTGAC GCAAGACGACATCGATAAGCTATTCGCCTCCGACCGTCCTCGAAGCCATGACCAGGTCACGCCAGGCGATGATCT GAGCCGGAAACGGCCGTATTCAAGCATATCGACAGGCGATGTCAACACTCCGGTGGCGACTCGGCAGGCACCCTG GGGCTCGGAAGTTCGACCATCAGCTTCGTCCGAGGGCTTCTCCCATGAAGGGTATGCGAACAGCGCTCTGGCGCC GCAGCCGTCGGCGATGAAGCCCGAAGTAATTCCGTCGAAGCCGCCTGTGGCCTCGATGGATGCCTCCATGGCCGA CGTCGACGAAGTGCTCGACGTTGACGAGGAGGCCCTGAAGGAGTCAGTCTTGTCCGACACGAAAAAGACTAGTCA GTCGCTAATGGGCTTTCTCGACAGGTACCTGACGACGATGCAACCTGCGTTTCCGATCCTACCCAGCACCATTTG GCGCATGCAGTCGCTGCTGTCACAGTGCCCGTCGTCTCTCCGGGAAGCGTTCCGCATCGCACTCGTGACGGCGGC GCAACAAGGCACTGCGGGCGATGTCAAGCATGCTGACGCCCTCTTACGTGAGTGGGAGAACAGTGATGTGCCGAG CAGCCGGGCGTCGGACATGGTGCACGCCCAGACGCTCTTGCTACTCAGCATAGATGCCGACCGGCGAGAACTTCC GACGCTGTCGTCATTGCTGGCGCGGGCGGTGGCGCTGGCAAATAGTATGAAGCTCTGGAAGCTCGTGACGGTGGA CGCAACAGACGGGGACTCGGACGATGCCCTGTTGCTCAAGATCTGGTGGTCGCTGATCCTGATGGACCGCTGGCA CGCGGCAGGGACGGGAAAGCCGGTGTTGATTCCCGACAGCAGTGTTGTGGCGATGGCCGGCCTGGCAGCGGTCGT GGGCGAGATCTGCTTCTATCTAACGAGTGAGTGGCACGCGGGACGGATCCCAAGCGGGCTCGTGAGCTGACGCGG TGATGAGCAGGACTATCCAAGGTTCTCGTCAAGATTGCAAACGTGCTGTCAGGCATGCCAGTCGGAGCGACGGCG GCAGACGCGAACATGGCGACAATGCTGAGAGACTACGTGGAGGACTACAGGGAAGATCTTCCGGCGCACGTGGAT GTGACATCGTACCCGCTGGTGCATCTGGCATACTGGCATTGCCGGCTACTGGCGACGCTGTTGACGCCGGGAGCG ACGGCGCTGGAGATGATGTGGCCAGCGCGGGAGCTCAGTGGTCTGCTGCTGGCGGATGGGCAGCAGCGGAGCCCG CTAACGCACCACTTCGCGTCGTTGGCGGCGCTGTGCCTGACGAAACTGTCCAAGACGGACAAGACGCGCGAGGAG GCGACGCAGCTCATTCACGACATGGTGGAGGCGGCGCCGGAGGGCCAGTGGGACGGGGTGCAGGCATGGCTGGCT GAGCATATGCGACCGCCGTCGTCTGCGGAGGCGACGGCCAGCCAAGGACTGCAGCATCTGGCGGACCTGGCGACG GCGCACGAGGGCATGACGGCAGCCGACGGCGAGGTGGTTGCCTTTGGGCCGGCCCTGGCGGCGGGCTACTTGGGC GTGCAGTGA |