Fungal Genomics

Agaricus bisporus var bisporus H39 Agaricus bisporus var bisporus H97 Agaricus bisporus var burnettii H119p4 Aspergillus niger CBS 112.32 Aspergillus niger CBS 113.50 Aspergillus niger CBS 115988 Aspergillus niger CBS 115989 Aspergillus niger CBS 118.52 Aspergillus niger CBS 124.48 Aspergillus niger CBS 131.52 Aspergillus niger CBS 133816 Aspergillus niger CBS 147320 Aspergillus niger CBS 147321 Aspergillus niger CBS 147322 Aspergillus niger CBS 147323 Aspergillus niger CBS 147324 Aspergillus niger CBS 147343 Aspergillus niger CBS 147344 Aspergillus niger CBS 147345 Aspergillus niger CBS 147346 Aspergillus niger CBS 147347 Aspergillus niger CBS 147352 Aspergillus niger CBS 147353 Aspergillus niger CBS 147371 Aspergillus niger CBS 147482 Aspergillus niger CBS 630.78 Aspergillus niger CBS 769.97 Niveomyces coronatus CBS 149186 Ophiocordyceps australis 1348a (Ghana) Ophiocordyceps australis map64 (Brazil) Ophiocordyceps camponoti-floridani Ophiocordyceps camponoti-rufipedis Ophiocordyceps kimflemingae Ophiocordyceps subramaniannii Penicillium roqueforti DTO002I6 Penicillium roqueforti DTO003C3 Penicillium roqueforti DTO003H1 (CBS 147308) Penicillium roqueforti DTO006G1 Penicillium roqueforti DTO006G7 Penicillium roqueforti DTO012A1 Penicillium roqueforti DTO012A2 (CBS 147309) Penicillium roqueforti DTO012A6 (CBS 147310) Penicillium roqueforti DTO012A7 Penicillium roqueforti DTO012A8 Penicillium roqueforti DTO012A9 Penicillium roqueforti DTO013E5 Penicillium roqueforti DTO013F2 Penicillium roqueforti DTO013F5 (CBS 147311) Penicillium roqueforti DTO027I6 Penicillium roqueforti DTO032C6 Penicillium roqueforti DTO039G3 Penicillium roqueforti DTO046C5 Penicillium roqueforti DTO070G2 (CBS 147317) Penicillium roqueforti DTO081F9 (CBS 147318) Penicillium roqueforti DTO101D6 (CBS 147325) Penicillium roqueforti DTO102I9 (CBS 147326) Penicillium roqueforti DTO126G2 (CBS 147330) Penicillium roqueforti DTO127F7 (CBS 147331) Penicillium roqueforti DTO127F9 (CBS 147332) Penicillium roqueforti DTO130C1 (CBS 147333) Penicillium roqueforti DTO163C3 (CBS 147337) Penicillium roqueforti DTO163F5 (CBS 147338) Penicillium roqueforti DTO163G4 (CBS 147339) Penicillium roqueforti DTO265D5 (CBS 147372) Penicillium roqueforti DTO369A1 (CBS 147354) Penicillium roqueforti DTO375B1 (CBS 147355) Penicillium roqueforti DTO377G2 (LCP 96.3914a) Penicillium roqueforti LCP96 04111 Rhodonia placenta FPRL280 Torrubiellomyces zombiae CBS 149187

General Properties

Protein ID	Ophio5|1012
Gene name
Location	scaffold_130:15651..19179
Strand	+
Gene length (bp)	3528
Transcript length (bp)	3060
Coding sequence length (bp)	3057
Protein length (aa)	1019

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PFAM Domains

PFAM Domain ID	Short name	Long name	E-value	Start	End
PF04082	Fungal_trans	Fungal specific transcription factor domain	1.1E-23	282	539
PF00172	Zn_clus	Fungal Zn(2)-Cys(6) binuclear cluster domain	2.2E-10	75	111

Swissprot hits

GO

GO Term	Description	Terminal node
GO:0006351	transcription, DNA-templated	Yes
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Yes
GO:0006355	regulation of transcription, DNA-templated	Yes
GO:0008270	zinc ion binding	Yes
GO:0003677	DNA binding	Yes
GO:0003676	nucleic acid binding	No
GO:0019219	regulation of nucleobase-containing compound metabolic process	No
GO:0003674	molecular_function	No
GO:0044237	cellular metabolic process	No
GO:0043169	cation binding	No
GO:0043167	ion binding	No
GO:0008152	metabolic process	No
GO:0006139	nucleobase-containing compound metabolic process	No
GO:1901576	organic substance biosynthetic process	No
GO:0010468	regulation of gene expression	No
GO:0046872	metal ion binding	No
GO:0046483	heterocycle metabolic process	No
GO:0051171	regulation of nitrogen compound metabolic process	No
GO:0065007	biological regulation	No
GO:0090304	nucleic acid metabolic process	No
GO:0044238	primary metabolic process	No
GO:0031323	regulation of cellular metabolic process	No
GO:0140110	transcription regulator activity	No
GO:0050794	regulation of cellular process	No
GO:0019222	regulation of metabolic process	No
GO:0018130	heterocycle biosynthetic process	No
GO:0060255	regulation of macromolecule metabolic process	No
GO:0006725	cellular aromatic compound metabolic process	No
GO:0008150	biological_process	No
GO:1901360	organic cyclic compound metabolic process	No
GO:0003700	DNA-binding transcription factor activity	No
GO:0009058	biosynthetic process	No
GO:0044249	cellular biosynthetic process	No
GO:0034641	cellular nitrogen compound metabolic process	No
GO:0051252	regulation of RNA metabolic process	No
GO:0031326	regulation of cellular biosynthetic process	No
GO:0006807	nitrogen compound metabolic process	No
GO:1901362	organic cyclic compound biosynthetic process	No
GO:0010556	regulation of macromolecule biosynthetic process	No
GO:0046914	transition metal ion binding	No
GO:2001141	regulation of RNA biosynthetic process	No
GO:1903506	regulation of nucleic acid-templated transcription	No
GO:0097159	organic cyclic compound binding	No
GO:0034654	nucleobase-containing compound biosynthetic process	No
GO:0019438	aromatic compound biosynthetic process	No
GO:0050789	regulation of biological process	No
GO:0016070	RNA metabolic process	No
GO:0097659	nucleic acid-templated transcription	No
GO:0009889	regulation of biosynthetic process	No
GO:0009059	macromolecule biosynthetic process	No
GO:0080090	regulation of primary metabolic process	No
GO:1901363	heterocyclic compound binding	No
GO:0044271	cellular nitrogen compound biosynthetic process	No
GO:0032774	RNA biosynthetic process	No
GO:0009987	cellular process	No
GO:0043170	macromolecule metabolic process	No
GO:0005488	binding	No
GO:0071704	organic substance metabolic process	No

SignalP

[Help with interpreting these statistics]

SignalP signal predicted	Location (based on Ymax)	D score (significance: > 0.45)
No	1 - 21	0.45

Transmembrane Domains

(None)

Transcription Factor Class

Transcription Factor Class (based on PFAM domains)
Fungal Specific TF

Expression data

Analysis 1: Expression analysis during behavioral modification. Published in De Bekker et al., 2017.

Expression values

Label	Description	Expression (RPKM)	Confidence interval (low)	Confidence interval (high)
SC16a	Pure fungal culture	51.11	27.30	74.91
CcL	In ants, during behavior modification	47.64	23.39	71.89
CcD	In ants, recently dead	34.70	18.78	50.62

Differential expression

Label1	Label2	Q-value	Significant difference
SC16a	CcL	0.811366	no
SC16a	CcD	0.091805	no
CcL	CcD	0.207310	no

Sequences

Type of sequence	Sequence
Locus	Download genbank file of locus The gene with 5 kb flanks (if sufficient flanking sequence is available). For use in cloning design programs. NOTE: features (genes or exons) that are only partially contained within the sequence are completely excluded.
Protein	>Ophio5|1012 MPSLLAQPGLPLCLGVSVLSMSGDLSDDDAVGDWQLHHASSPADSAKSDAELDDKAASDPSAPSQPIQKRRRVTR ACDECRRKKIKCDGKQPCTHCSVYSYECTYDKPSNRRRNPAPQYIEALENRLQRAEALLRKYMPDVDLADPNLDP TIQQEFLNRQRARAKQHHSSADDPTSHSDAKLMTMIDSIGQLDLDDKGEWDFHGTSSGAVFLRRMKDHLRGMLGP PTKAPFLPRPERPPGLMALGSPSPRGGSPLSTASAIAELPGPSKDAARKLCYYSLSCATCLVRIVHVPSFYERFE RVYDRPVDSLDQEDTRFLGLIYAVLALGCMYSNLDDAKPESGAYKAAIDQGFKYYKMARGLLQDLAECRDIPSLQ ALLYMILFLQATSNLSACYSFIGVALRSALRIGLHRHLQHDKIGVVEQQVRRRVFYVIRQLDIYVSTMLGFPLLL NLDDVDQAYPVEVDDEYVLETGIMSPPAGTPSFFEAFNAQTRLMEVLGKITKYVYPMQGQDQPTAKGAPTYLISY ARIKEIETELQTWYERLPEMWRPSPEGPIEVVRVRHLLRFAYAHVQLVLYRPFLHYISPRLSQASEVDELSYACA AAAISVSRNIVHIGLEIRKQGVLSGPYWFMLYTEFFAVLSLVFYALENPDKPGSQEVLADAWAGRRMIADLADKS MSADRVTNALKPLFDQLPESLDQARTRPLPSKKRSAVPGKTESCVSPHALASPGPSTQRIGDFARAGASTLQKAP LASPASQVSVDSSGQSMEHVIPGLSFAAGMQDVIPMDLSSRATPELSGSGSSQRQRLWSQQPQQGTPNSVNKLDS LMFPSDDPFAYPNQLMMELGFQPKADGTSAAMPTSGHDAPAFFTTSLDELGDDMLGHNQSYMMQQQQQQQQLHHQ QQLLFGLTGNLYDPHDMMAMHTAQHQQQQQQQQQQQQQQHQYQQQQQQQQQQQERQYQQQQVPRSSAPPQGHRSI FSSFRRTRSDRQQARQIEQLFTQQGMQPDWGSFFGSGRGGFQGM
Coding	>Ophio5|1012 ATGCCCTCTTTGCTTGCCCAGCCCGGCCTCCCACTGTGCCTTGGAGTCTCTGTTCTCAGCATGTCTGGCGACCTG TCCGACGATGACGCCGTCGGCGACTGGCAGCTGCACCATGCTTCATCGCCCGCCGATAGCGCTAAATCCGACGCC GAGCTCGACGACAAGGCTGCTTCGGATCCCTCTGCGCCCTCACAGCCCATTCAGAAGCGCCGCCGAGTCACGCGC GCATGCGACGAGTGTCGCCGCAAGAAGATCAAGTGTGATGGCAAGCAGCCCTGCACCCATTGCTCCGTCTATAGC TATGAATGTACATACGACAAGCCCTCCAACAGAAGGAGAAATCCGGCTCCTCAGTACATCGAAGCCCTCGAGAAC CGTCTGCAGCGCGCAGAGGCGCTCCTCCGCAAGTATATGCCCGATGTCGACTTGGCCGACCCCAACCTCGACCCT ACCATCCAGCAGGAATTTCTCAACCGTCAAAGGGCTCGCGCGAAGCAGCATCATAGCTCGGCCGACGATCCGACA AGCCACAGCGACGCCAAGCTGATGACCATGATTGACTCCATCGGCCAGCTTGATCTCGATGACAAGGGCGAATGG GACTTTCACGGCACCTCGTCCGGCGCCGTCTTCCTGAGGCGGATGAAGGATCATCTCCGCGGTATGCTTGGTCCT CCGACCAAGGCTCCGTTTCTGCCCCGCCCTGAGCGTCCCCCGGGCCTGATGGCTTTGGGATCGCCGTCTCCCCGC GGAGGCTCCCCTCTCTCGACCGCGTCTGCCATAGCCGAACTGCCCGGGCCTTCCAAGGATGCCGCCCGCAAGCTG TGCTACTACTCGCTGAGCTGCGCCACGTGCCTCGTCCGCATCGTTCACGTACCCTCCTTTTACGAGAGATTCGAA CGAGTCTATGACCGTCCAGTTGACAGCCTCGATCAAGAGGACACACGCTTCTTGGGACTCATCTATGCCGTCCTC GCCCTCGGCTGCATGTACAGCAACCTGGACGACGCCAAGCCCGAGAGCGGAGCCTACAAGGCGGCCATTGACCAA GGCTTCAAGTATTACAAGATGGCGAGGGGGCTTCTGCAGGATCTGGCCGAGTGCCGTGACATCCCCTCGCTCCAG GCTTTGTTGTACATGATCCTCTTTCTCCAAGCCACGTCGAACCTCAGTGCCTGCTACTCCTTCATCGGCGTCGCG CTGCGGTCGGCACTGCGCATCGGCCTCCACCGACATCTGCAGCATGACAAGATTGGCGTTGTCGAGCAACAGGTG CGGAGGCGGGTCTTTTACGTGATTCGGCAGCTGGACATTTACGTCTCGACCATGCTCGGCTTCCCACTCCTCCTC AACCTCGACGATGTCGATCAGGCGTACCCGGTCGAGGTCGACGACGAGTACGTCTTGGAAACGGGCATCATGTCA CCGCCCGCCGGGACGCCGTCCTTCTTCGAAGCCTTCAACGCGCAGACTCGACTGATGGAGGTGCTCGGCAAGATT ACCAAATACGTGTACCCGATGCAGGGACAGGACCAGCCCACCGCCAAGGGTGCCCCGACCTATCTCATCAGCTAC GCCCGCATCAAGGAGATCGAGACGGAGCTGCAGACATGGTACGAGAGGCTACCGGAGATGTGGCGGCCGAGCCCG GAGGGACCAATCGAGGTAGTGCGGGTGCGGCACTTGCTTCGGTTTGCATACGCACATGTGCAGCTCGTCCTTTAC CGGCCCTTTTTGCATTACATATCTCCCCGTCTCAGCCAGGCTAGCGAAGTGGACGAACTATCGTATGCCTGCGCC GCCGCGGCCATCAGCGTGTCACGAAACATTGTCCACATAGGTCTGGAGATCCGCAAGCAGGGCGTCCTCAGCGGG CCGTACTGGTTCATGCTCTACACCGAATTCTTTGCCGTTCTCTCTCTCGTCTTCTACGCGCTCGAAAACCCGGAC AAGCCAGGGTCGCAGGAAGTGCTGGCCGATGCTTGGGCTGGGAGGCGGATGATTGCCGACCTGGCCGACAAGAGC ATGTCCGCCGACCGGGTGACGAACGCTCTCAAGCCCCTGTTCGATCAACTACCCGAGAGCCTCGACCAGGCTCGC ACACGGCCGCTGCCCTCGAAGAAGAGGTCCGCTGTCCCGGGCAAGACCGAGTCGTGCGTATCGCCCCACGCCCTT GCGAGCCCCGGCCCGTCGACGCAGCGGATCGGCGACTTTGCACGCGCTGGCGCCTCGACGCTGCAAAAGGCCCCC CTCGCCTCGCCGGCGTCGCAGGTCTCGGTCGACAGCTCAGGGCAGTCGATGGAGCATGTCATACCGGGACTGTCG TTTGCAGCAGGCATGCAGGACGTGATCCCGATGGATCTGTCTTCACGGGCGACGCCCGAATTGTCCGGCTCGGGG AGCTCCCAGCGGCAACGGCTCTGGTCTCAACAACCCCAGCAGGGCACGCCCAACTCCGTGAACAAGCTGGATTCG CTCATGTTCCCATCCGACGATCCGTTTGCGTACCCCAACCAGCTGATGATGGAGCTCGGCTTCCAGCCTAAGGCG GACGGGACGTCGGCAGCAATGCCAACCTCGGGCCACGACGCTCCCGCCTTCTTTACGACGTCGCTGGACGAGTTG GGCGATGATATGCTGGGCCACAATCAGTCCTACATGATGCAGCAGCAGCAGCAGCAGCAGCAGCTCCATCACCAG CAGCAGCTGCTGTTTGGTCTCACGGGAAATCTTTACGACCCCCACGATATGATGGCAATGCACACGGCACAGCAT CAACAACAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCATCAATACCAGCAGCAGCAACAACAGCAGCAG CAGCAGCAGGAACGACAGTATCAGCAGCAGCAAGTCCCACGAAGCTCGGCGCCGCCGCAAGGCCATCGGAGCATC TTCTCGAGCTTCCGGCGAACGCGTTCGGATCGGCAGCAAGCCAGGCAAATCGAGCAGCTGTTTACGCAGCAGGGA ATGCAGCCCGACTGGGGGAGTTTCTTTGGTTCTGGAAGAGGAGGATTTCAAGGAATG
Transcript	>Ophio5|1012 ATGCCCTCTTTGCTTGCCCAGCCCGGCCTCCCACTGTGCCTTGGAGTCTCTGTTCTCAGCATGTCTGGCGACCTG TCCGACGATGACGCCGTCGGCGACTGGCAGCTGCACCATGCTTCATCGCCCGCCGATAGCGCTAAATCCGACGCC GAGCTCGACGACAAGGCTGCTTCGGATCCCTCTGCGCCCTCACAGCCCATTCAGAAGCGCCGCCGAGTCACGCGC GCATGCGACGAGTGTCGCCGCAAGAAGATCAAGTGTGATGGCAAGCAGCCCTGCACCCATTGCTCCGTCTATAGC TATGAATGTACATACGACAAGCCCTCCAACAGAAGGAGAAATCCGGCTCCTCAGTACATCGAAGCCCTCGAGAAC CGTCTGCAGCGCGCAGAGGCGCTCCTCCGCAAGTATATGCCCGATGTCGACTTGGCCGACCCCAACCTCGACCCT ACCATCCAGCAGGAATTTCTCAACCGTCAAAGGGCTCGCGCGAAGCAGCATCATAGCTCGGCCGACGATCCGACA AGCCACAGCGACGCCAAGCTGATGACCATGATTGACTCCATCGGCCAGCTTGATCTCGATGACAAGGGCGAATGG GACTTTCACGGCACCTCGTCCGGCGCCGTCTTCCTGAGGCGGATGAAGGATCATCTCCGCGGTATGCTTGGTCCT CCGACCAAGGCTCCGTTTCTGCCCCGCCCTGAGCGTCCCCCGGGCCTGATGGCTTTGGGATCGCCGTCTCCCCGC GGAGGCTCCCCTCTCTCGACCGCGTCTGCCATAGCCGAACTGCCCGGGCCTTCCAAGGATGCCGCCCGCAAGCTG TGCTACTACTCGCTGAGCTGCGCCACGTGCCTCGTCCGCATCGTTCACGTACCCTCCTTTTACGAGAGATTCGAA CGAGTCTATGACCGTCCAGTTGACAGCCTCGATCAAGAGGACACACGCTTCTTGGGACTCATCTATGCCGTCCTC GCCCTCGGCTGCATGTACAGCAACCTGGACGACGCCAAGCCCGAGAGCGGAGCCTACAAGGCGGCCATTGACCAA GGCTTCAAGTATTACAAGATGGCGAGGGGGCTTCTGCAGGATCTGGCCGAGTGCCGTGACATCCCCTCGCTCCAG GCTTTGTTGTACATGATCCTCTTTCTCCAAGCCACGTCGAACCTCAGTGCCTGCTACTCCTTCATCGGCGTCGCG CTGCGGTCGGCACTGCGCATCGGCCTCCACCGACATCTGCAGCATGACAAGATTGGCGTTGTCGAGCAACAGGTG CGGAGGCGGGTCTTTTACGTGATTCGGCAGCTGGACATTTACGTCTCGACCATGCTCGGCTTCCCACTCCTCCTC AACCTCGACGATGTCGATCAGGCGTACCCGGTCGAGGTCGACGACGAGTACGTCTTGGAAACGGGCATCATGTCA CCGCCCGCCGGGACGCCGTCCTTCTTCGAAGCCTTCAACGCGCAGACTCGACTGATGGAGGTGCTCGGCAAGATT ACCAAATACGTGTACCCGATGCAGGGACAGGACCAGCCCACCGCCAAGGGTGCCCCGACCTATCTCATCAGCTAC GCCCGCATCAAGGAGATCGAGACGGAGCTGCAGACATGGTACGAGAGGCTACCGGAGATGTGGCGGCCGAGCCCG GAGGGACCAATCGAGGTAGTGCGGGTGCGGCACTTGCTTCGGTTTGCATACGCACATGTGCAGCTCGTCCTTTAC CGGCCCTTTTTGCATTACATATCTCCCCGTCTCAGCCAGGCTAGCGAAGTGGACGAACTATCGTATGCCTGCGCC GCCGCGGCCATCAGCGTGTCACGAAACATTGTCCACATAGGTCTGGAGATCCGCAAGCAGGGCGTCCTCAGCGGG CCGTACTGGTTCATGCTCTACACCGAATTCTTTGCCGTTCTCTCTCTCGTCTTCTACGCGCTCGAAAACCCGGAC AAGCCAGGGTCGCAGGAAGTGCTGGCCGATGCTTGGGCTGGGAGGCGGATGATTGCCGACCTGGCCGACAAGAGC ATGTCCGCCGACCGGGTGACGAACGCTCTCAAGCCCCTGTTCGATCAACTACCCGAGAGCCTCGACCAGGCTCGC ACACGGCCGCTGCCCTCGAAGAAGAGGTCCGCTGTCCCGGGCAAGACCGAGTCGTGCGTATCGCCCCACGCCCTT GCGAGCCCCGGCCCGTCGACGCAGCGGATCGGCGACTTTGCACGCGCTGGCGCCTCGACGCTGCAAAAGGCCCCC CTCGCCTCGCCGGCGTCGCAGGTCTCGGTCGACAGCTCAGGGCAGTCGATGGAGCATGTCATACCGGGACTGTCG TTTGCAGCAGGCATGCAGGACGTGATCCCGATGGATCTGTCTTCACGGGCGACGCCCGAATTGTCCGGCTCGGGG AGCTCCCAGCGGCAACGGCTCTGGTCTCAACAACCCCAGCAGGGCACGCCCAACTCCGTGAACAAGCTGGATTCG CTCATGTTCCCATCCGACGATCCGTTTGCGTACCCCAACCAGCTGATGATGGAGCTCGGCTTCCAGCCTAAGGCG GACGGGACGTCGGCAGCAATGCCAACCTCGGGCCACGACGCTCCCGCCTTCTTTACGACGTCGCTGGACGAGTTG GGCGATGATATGCTGGGCCACAATCAGTCCTACATGATGCAGCAGCAGCAGCAGCAGCAGCAGCTCCATCACCAG CAGCAGCTGCTGTTTGGTCTCACGGGAAATCTTTACGACCCCCACGATATGATGGCAATGCACACGGCACAGCAT CAACAACAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCATCAATACCAGCAGCAGCAACAACAGCAGCAG CAGCAGCAGGAACGACAGTATCAGCAGCAGCAAGTCCCACGAAGCTCGGCGCCGCCGCAAGGCCATCGGAGCATC TTCTCGAGCTTCCGGCGAACGCGTTCGGATCGGCAGCAAGCCAGGCAAATCGAGCAGCTGTTTACGCAGCAGGGA ATGCAGCCCGACTGGGGGAGTTTCTTTGGTTCTGGAAGAGGAGGATTTCAAGGAATGTAA
Gene	>Ophio5|1012 ATGCCCTCTTTGCTTGCCCAGCCCGGGTCCTGCAGTCCACCACGCCGCTCGCCTCGGCGCTTGACCAACGGCCTC GGCGCTGGCCCTGCTTGACGCTTTGAAAAGCCTCCCACTGTGCCTTGGAGTCTCTGTGTAAGCCTCGTCTTCTGC TGTTCTTGTCTTCCTGTCGAGATAAAGAAAGATTAGAAAATGTTGAGGAAAGGGGAGAGAAAAGAGAGAAATCCT GATATCATCATCCCATCTCCGTTCGTCTCACCGTTCCTCGGCACCAATCTGACAGACTCTCCCAGTCTCAGCATG TCTGGCGACCTGTCCGACGATGACGCCGTCGGCGACTGGCAGCTGCACCATGCTTCATCGCCCGCCGATAGCGCT AAATCCGACGCCGAGCTCGACGACAAGGCTGCTTCGGATCCCTCTGCGCCCTCACAGCCCATTCAGAAGCGCCGC CGAGTCACGCGCGCATGCGACGAGTGTCGCCGCAAGAAGATCAAGTGTGATGGCAAGCAGCCCTGCACCCATTGC TCCGTCTATAGCTATGGTGTGCCGGCCCACTCGTCCATGTCCTCTCGTCCGAATACTCACTGCCGGTCCAGAATG TACATACGACAAGCCCTCCAACAGAAGGAGAAATCCGGCTCCTCAGTACATCGAAGCCCTCGAGAACCGTCTGCA GCGCGCAGAGGCGCTCCTCCGCAAGTATATGCCCGATGTCGACTTGGCCGACCCCAACCTCGACCCTACCATCCA GCAGGAATTTCTCAACCGTCAAAGGGCTCGCGCGAAGCAGCATCATAGCTCGGCCGACGATCCGACAAGCCACAG CGACGCCAAGCTGATGACCATGATTGACTCCATCGGCCAGCTTGATCTCGATGACAAGGGCGAATGGGACTTTCA CGGCACCTCGTCCGGCGCCGTCTTCCTGAGGCGGATGAAGGATCATCTCCGCGGTATGCTTGGTCCTCCGACCAA GGCTCCGTTTCTGCCCCGCCCTGAGCGTCCCCCGGGCCTGATGGCTTTGGGATCGCCGTCTCCCCGCGGAGGCTC CCCTCTCTCGACCGCGTCTGCCATAGCCGAACTGCCCGGGCCTTCCAAGGATGCCGCCCGCAAGCTGTGCTACTA CTCGCTGAGCTGCGCCACGTGCCTCGTCCGCATCGTTCACGTACCCTCCTTTTACGAGAGATTCGAACGAGTCTA TGACCGTCCAGTTGACAGCCTCGATCAAGAGGACACACGCTTCTTGGGACTCATCTATGCCGTCCTCGCCCTCGG CTGCATGTACAGCAACCTGGACGACGCCAAGCCCGAGAGCGGAGCCTACAAGGCGGCCATTGACCAAGGGTGTGT TTGCTTCCCTCTCCGTCTTTTCCCTCAGCTGACCAGATGCCCTCTTGCGCAGCTTCAAGTATTACAAGATGGCGA GGGGGCTTCTGCAGGATCTGGCCGAGTGCCGTGACATCCCCTCGCTCCAGGCTTTGTTGTACATGATCCTCTTTC TCCAAGCCACGTCGAACCTCAGTGCCTGCTACTCCTTCATCGGCGTCGCGCTGCGGTCGGCACTGCGCATCGGCC TCCACCGACATCTGCAGCATGACAAGATTGGCGTTGTCGAGCAACAGGTGCGGAGGCGGGTCTTTTACGTGATTC GGCAGCTGGACATTTACGTCTCGACCATGCTCGGCTTCCCACTCCTCCTCAACCTCGACGATGTCGATCAGGCGT ACCCGGTCGAGGTCGACGACGAGTACGTCTTGGAAACGGGCATCATGTCACCGCCCGCCGGGACGCCGTCCTTCT TCGAAGCCTTCAACGCGCAGACTCGACTGATGGAGGTGCTCGGCAAGATTACCAAATACGTGTACCCGATGCAGG GACAGGACCAGCCCACCGCCAAGGGTGCCCCGACCTATCTCATCAGCTACGCCCGCATCAAGGAGATCGAGACGG AGCTGCAGACATGGTACGAGAGGCTACCGGAGATGTGGCGGCCGAGCCCGGAGGGACCAATCGAGGTAGTGCGGT GAGTTCATGGCCATTGGCTTTCCGGGTCGCGCCGTGGATGCTCAACTGACTCGGACGTCAGGGTGCGGCACTTGC TTCGGTTTGCATACGCACATGTGCAGCTCGTCCTTTACCGGCCCTTTTTGCATTACATATCTCCCCGTCTCAGCC AGGCTAGCGAAGTGGACGAACTATCGTATGCCTGCGCCGCCGCGGCCATCAGCGTGTCACGAAACATTGTCCACA TAGGTCTGGAGATCCGCAAGCAGGGCGTCCTCAGCGGGCCGTACTGGTTCATGCTCTACACCGAATTCTTTGCCG TTCTCTCTCTCGTCTTCTACGCGCTCGAAAACCCGGACAAGCCAGGGTCGCAGGAAGTGCTGGCCGATGCTTGGG CTGGGAGGCGGATGATTGCCGACCTGGCCGACAAGAGCATGTCCGCCGACCGGGTGACGAACGCTCTCAAGGTAC GCTTCAAGAGCTCAACAAGTCTTGAAAATCTTAATGACCCAAAATGACCAGCCCCTGTTCGATCAACTACCCGAG AGCCTCGACCAGGCTCGCACACGGCCGCTGCCCTCGAAGAAGAGGTCCGCTGTCCCGGGCAAGACCGAGTCGTGC GTATCGCCCCACGCCCTTGCGAGCCCCGGCCCGTCGACGCAGCGGATCGGCGACTTTGCACGCGCTGGCGCCTCG ACGCTGCAAAAGGCCCCCCTCGCCTCGCCGGCGTCGCAGGTCTCGGTCGACAGCTCAGGGCAGTCGATGGAGCAT GTCATACCGGGACTGTCGTTTGCAGCAGGCATGCAGGACGTGATCCCGATGGATCTGTCTTCACGGGCGACGCCC GAATTGTCCGGCTCGGGGAGCTCCCAGCGGCAACGGCTCTGGTCTCAACAACCCCAGCAGGGCACGCCCAACTCC GTGAACAAGCTGGATTCGCTCATGTTCCCATCCGACGATCCGTTTGCGTACCCCAACCAGCTGATGATGGAGCTC GGCTTCCAGCCTAAGGCGGACGGGACGTCGGCAGCAATGCCAACCTCGGGCCACGACGCTCCCGCCTTCTTTACG ACGTCGCTGGACGAGTTGGGCGATGATATGCTGGGCCACAATCAGTCCTACATGATGCAGCAGCAGCAGCAGCAG CAGCAGCTCCATCACCAGCAGCAGCTGCTGTTTGGTCTCACGGGAAATCTTTACGACCCCCACGATATGATGGCA ATGCACACGGCACAGCATCAACAACAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCATCAATACCAGCAG CAGCAACAACAGCAGCAGCAGCAGCAGGAACGACAGTATCAGCAGCAGCAAGTCCCACGAAGCTCGGCGCCGCCG CAAGGCCATCGGAGCATCTTCTCGAGCTTCCGGCGAACGCGTTCGGATCGGCAGCAAGCCAGGCAAATCGAGCAG CTGTTTACGCAGCAGGGAATGCAGCCCGACTGGGGGAGTTTCTTTGGTTCTGGAAGAGGAGGATTTCAAGGAATG TAA