Fungal Genomics

Agaricus bisporus var bisporus H39 Agaricus bisporus var bisporus H97 Agaricus bisporus var burnettii H119p4 Aspergillus niger CBS 112.32 Aspergillus niger CBS 113.50 Aspergillus niger CBS 115988 Aspergillus niger CBS 115989 Aspergillus niger CBS 118.52 Aspergillus niger CBS 124.48 Aspergillus niger CBS 131.52 Aspergillus niger CBS 133816 Aspergillus niger CBS 147320 Aspergillus niger CBS 147321 Aspergillus niger CBS 147322 Aspergillus niger CBS 147323 Aspergillus niger CBS 147324 Aspergillus niger CBS 147343 Aspergillus niger CBS 147344 Aspergillus niger CBS 147345 Aspergillus niger CBS 147346 Aspergillus niger CBS 147347 Aspergillus niger CBS 147352 Aspergillus niger CBS 147353 Aspergillus niger CBS 147371 Aspergillus niger CBS 147482 Aspergillus niger CBS 630.78 Aspergillus niger CBS 769.97 Niveomyces coronatus CBS 149186 Ophiocordyceps australis 1348a (Ghana) Ophiocordyceps australis map64 (Brazil) Ophiocordyceps camponoti-floridani Ophiocordyceps camponoti-rufipedis Ophiocordyceps kimflemingae Ophiocordyceps subramaniannii Penicillium roqueforti DTO002I6 Penicillium roqueforti DTO003C3 Penicillium roqueforti DTO003H1 (CBS 147308) Penicillium roqueforti DTO006G1 Penicillium roqueforti DTO006G7 Penicillium roqueforti DTO012A1 Penicillium roqueforti DTO012A2 (CBS 147309) Penicillium roqueforti DTO012A6 (CBS 147310) Penicillium roqueforti DTO012A7 Penicillium roqueforti DTO012A8 Penicillium roqueforti DTO012A9 Penicillium roqueforti DTO013E5 Penicillium roqueforti DTO013F2 Penicillium roqueforti DTO013F5 (CBS 147311) Penicillium roqueforti DTO027I6 Penicillium roqueforti DTO032C6 Penicillium roqueforti DTO039G3 Penicillium roqueforti DTO046C5 Penicillium roqueforti DTO070G2 (CBS 147317) Penicillium roqueforti DTO081F9 (CBS 147318) Penicillium roqueforti DTO101D6 (CBS 147325) Penicillium roqueforti DTO102I9 (CBS 147326) Penicillium roqueforti DTO126G2 (CBS 147330) Penicillium roqueforti DTO127F7 (CBS 147331) Penicillium roqueforti DTO127F9 (CBS 147332) Penicillium roqueforti DTO130C1 (CBS 147333) Penicillium roqueforti DTO163C3 (CBS 147337) Penicillium roqueforti DTO163F5 (CBS 147338) Penicillium roqueforti DTO163G4 (CBS 147339) Penicillium roqueforti DTO265D5 (CBS 147372) Penicillium roqueforti DTO369A1 (CBS 147354) Penicillium roqueforti DTO375B1 (CBS 147355) Penicillium roqueforti DTO377G2 (LCP 96.3914a) Penicillium roqueforti LCP96 04111 Rhodonia placenta FPRL280 Torrubiellomyces zombiae CBS 149187

General Properties

Protein ID	Ophcf2|01908
Gene name
Location	scaffold_02:2068325..2071106
Strand	-
Gene length (bp)	2781
Transcript length (bp)	2781
Coding sequence length (bp)	2781
Protein length (aa)	927

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PFAM Domains

PFAM Domain ID	Short name	Long name	E-value	Start	End
PF07724	AAA_2	AAA domain (Cdc48 subfamily)	2.2E-44	630	791
PF17871	AAA_lid_9	AAA lid domain	4.0E-31	362	462
PF00004	AAA	ATPase family associated with various cellular activities (AAA)	6.7E-14	221	338
PF00004	AAA	ATPase family associated with various cellular activities (AAA)	5.1E-09	632	750
PF10431	ClpB_D2-small	C-terminal, D2-small domain, of ClpB protein	1.7E-23	798	880
PF07728	AAA_5	AAA domain (dynein-related subfamily)	1.1E-09	631	749
PF00158	Sigma54_activat	Sigma-54 interaction domain	3.2E-06	627	745
PF02861	Clp_N	Clp amino terminal domain, pathogenicity island component	5.0E-04	110	157

GO

GO Term	Description	Terminal node
GO:0005524	ATP binding	Yes
GO:0006355	regulation of transcription, DNA-templated	Yes
GO:0008134	transcription factor binding	Yes
GO:0016887	ATP hydrolysis activity	Yes
GO:0016787	hydrolase activity	No
GO:0097159	organic cyclic compound binding	No
GO:0016817	hydrolase activity, acting on acid anhydrides	No
GO:0031323	regulation of cellular metabolic process	No
GO:0003824	catalytic activity	No
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	No
GO:0010556	regulation of macromolecule biosynthetic process	No
GO:1901265	nucleoside phosphate binding	No
GO:0017111	nucleoside-triphosphatase activity	No
GO:0032559	adenyl ribonucleotide binding	No
GO:0005488	binding	No
GO:0031326	regulation of cellular biosynthetic process	No
GO:0080090	regulation of primary metabolic process	No
GO:1901363	heterocyclic compound binding	No
GO:0043168	anion binding	No
GO:0019219	regulation of nucleobase-containing compound metabolic process	No
GO:0050789	regulation of biological process	No
GO:0050794	regulation of cellular process	No
GO:0035639	purine ribonucleoside triphosphate binding	No
GO:0065007	biological regulation	No
GO:0097367	carbohydrate derivative binding	No
GO:0051171	regulation of nitrogen compound metabolic process	No
GO:0030554	adenyl nucleotide binding	No
GO:0009889	regulation of biosynthetic process	No
GO:0008150	biological_process	No
GO:0043167	ion binding	No
GO:0010468	regulation of gene expression	No
GO:0060255	regulation of macromolecule metabolic process	No
GO:0036094	small molecule binding	No
GO:0016462	pyrophosphatase activity	No
GO:0003674	molecular_function	No
GO:0005515	protein binding	No
GO:0000166	nucleotide binding	No
GO:0019222	regulation of metabolic process	No
GO:2001141	regulation of RNA biosynthetic process	No
GO:0032555	purine ribonucleotide binding	No
GO:0051252	regulation of RNA metabolic process	No
GO:0017076	purine nucleotide binding	No
GO:1903506	regulation of nucleic acid-templated transcription	No
GO:0032553	ribonucleotide binding	No

SignalP

[Help with interpreting these statistics]

SignalP signal predicted	Location (based on Ymax)	D score (significance: > 0.45)
No	1 - 47	0.45

Transmembrane Domains

(None)

Transcription Factor Class

(None)

Expression data

Analysis 1: Expression analysis during behavioral modification. Published in: Will et al., G3, 2020

Expression values

Label	Description	Expression (RPKM)	Confidence interval (low)	Confidence interval (high)
Fungus	Fungus in pure culture	71.44	39.04	103.84
Alive	In ants, during behavior modification	85.90	44.96	126.84
Dead	In ants, recently dead	90.49	44.97	136.00

Differential expression

Label1	Label2	Q-value	Significant difference
Alive	Fungus	0.402674	no
Alive	Dead	0.822309	no
Dead	Fungus	0.273066	no

Sequences

Type of sequence	Sequence
Locus	Download genbank file of locus The gene with 5 kb flanks (if sufficient flanking sequence is available). For use in cloning design programs. NOTE: features (genes or exons) that are only partially contained within the sequence are completely excluded.
Protein	>Ophcf2|01908 MNARMDFTDRAQKAVEDSMALAEQYAHSQLLPVHLAVALLDPPVDQSKDQQNGPSQTNVTLFRQVVERARGDPQL FDRALKKMLVRLPSQDPPPEHISPSPSYHAVLRKAMELQKVQKDTFIGVDHLITALSEDSNIQQALRDSNIPKAK LMQDAVQAIRGTKRVDSKTADTEQENENLAKFTIDMTAMARDKKIDPVIGREEEIRRVVRILSRRTKNNPVLIGE PGVGKTTVVEGLAQRIVNRDVPDNLKHCKLLSLDVGALVAGSKYRGEFEERMKGVLKEIEDSTEMIVLFVDEIHL LMGAGSSGEGGMDAANLLKPMLARGQLHCIGATTLAEYRKYVEKDAAFERRFQQVMVKEPTIPETISILRGLKER YDRHHRVTILDSALVAAANLAARYLTSRRMPDSAIDLVDEAAAAVRVARESQPEIIDSLDRKLRQLMIEIAALEK EQDEASKTRLQQARKDAQNVEEELEPLREKYQNEIKRGEEIHQAKLKLDDLEKRLEDATNNGEHAKAADIKYGAI PEQEAVIHELEARKAAADAALNATGADSGGSMITDVVTADHINEIVARWTGIPVTRLRTSEKEKLVNMEKVLGKV VVGQKEAVQSVANAIRLQRSGLSNPNQPPSFLFCGPSGTGKTLLTKALAEFLFDDAKAMIRFDMSEYQERHALSR MIGAPPGYVGHDSGGQLTEALRRRPFSILLFDEVEKAAKEVLTVLLQLMDDGRITDGQGRVVDAKNCIVVMTSNL GAEFLTRPGAREGKVDGPTRELVMNALRNYFLPEFLNRINSVVIFNRLTRREIRKIVDLRLTEIQRRLEDNGRKV RIEVSDEAKDYLGSSGYSPAYGARPLARLIEKEVLNRLAILILRNNVRDGEIARVELDDGKIVVLSNHPDSEMGE DEDMMDDDDDAVDEVVGENMDEDIYN*
Coding	>Ophcf2|01908 ATGAACGCCCGCATGGACTTCACCGATAGGGCGCAGAAAGCCGTCGAGGACTCCATGGCCCTCGCCGAGCAATAC GCGCACTCGCAGCTTCTCCCCGTTCACCTGGCTGTCGCCCTTCTCGACCCCCCCGTCGATCAGTCCAAGGACCAG CAGAATGGTCCGTCTCAGACCAATGTCACCCTCTTCAGACAGGTCGTCGAGAGGGCCCGCGGCGATCCGCAGCTC TTCGATCGCGCGCTCAAGAAGATGCTCGTCCGGCTTCCGAGCCAGGACCCTCCGCCTGAGCACATCTCGCCCTCA CCATCATACCACGCCGTCCTGCGCAAGGCAATGGAGCTGCAAAAGGTTCAGAAGGATACCTTTATTGGCGTCGAC CACCTCATTACTGCCTTGTCCGAAGACAGCAATATTCAGCAGGCTCTGAGGGACAGCAACATCCCCAAAGCCAAG CTGATGCAGGATGCTGTCCAGGCTATCCGCGGCACCAAGCGCGTCGACAGCAAGACGGCCGACACGGAGCAGGAG AACGAGAACCTGGCCAAGTTTACCATCGACATGACAGCCATGGCCCGCGATAAGAAGATTGATCCCGTCATTGGA AGGGAGGAGGAGATTCGTCGCGTCGTGCGCATCCTATCTCGACGCACCAAGAACAACCCGGTCCTCATTGGCGAG CCAGGTGTCGGCAAGACAACCGTGGTCGAGGGCCTGGCGCAGCGCATCGTCAACCGGGACGTGCCCGACAACCTC AAACACTGCAAGCTCCTTTCGCTCGATGTCGGCGCTCTCGTCGCCGGCAGCAAGTACCGCGGCGAGTTTGAGGAA CGGATGAAGGGTGTACTCAAAGAGATTGAGGACTCCACAGAGATGATTGTCCTCTTCGTGGACGAGATCCATCTA CTCATGGGTGCCGGCTCTTCCGGCGAGGGAGGCATGGACGCTGCCAACCTGCTCAAGCCCATGCTCGCCCGCGGC CAGCTTCATTGCATCGGCGCCACGACGCTGGCCGAGTATCGGAAGTACGTGGAAAAGGACGCCGCGTTTGAGCGT CGCTTCCAACAAGTCATGGTCAAGGAGCCCACCATCCCCGAGACCATTTCCATCCTGCGAGGCCTCAAAGAACGC TACGACCGCCATCATCGCGTCACTATCCTCGACAGCGCCTTGGTGGCCGCTGCGAACCTGGCCGCGCGCTACTTG ACGTCGAGGCGCATGCCCGACTCGGCTATTGACCTGGTGGACGAGGCGGCGGCTGCCGTGCGGGTGGCGCGAGAG TCGCAGCCCGAGATTATCGATTCGCTCGACCGGAAACTGCGGCAGCTGATGATCGAAATCGCCGCGTTGGAGAAG GAACAAGATGAGGCGTCCAAGACGCGGCTGCAACAGGCCAGGAAGGACGCCCAAAACGTCGAGGAGGAGCTTGAG CCTCTCCGGGAGAAATACCAAAACGAGATCAAGAGGGGCGAGGAGATTCACCAAGCCAAGCTCAAGCTCGACGAC CTCGAGAAGCGACTGGAAGACGCGACCAACAACGGAGAGCACGCCAAGGCGGCCGACATCAAGTACGGTGCCATC CCCGAGCAGGAGGCCGTCATTCACGAGCTCGAGGCCCGCAAGGCGGCCGCCGACGCGGCTCTCAACGCGACGGGC GCTGATAGCGGCGGCTCCATGATTACCGACGTCGTCACGGCCGACCACATCAACGAGATTGTCGCCCGCTGGACC GGCATCCCCGTGACGCGGCTGAGGACGTCGGAGAAGGAGAAGCTGGTCAACATGGAAAAGGTGCTGGGAAAGGTG GTGGTGGGCCAGAAGGAGGCGGTCCAGTCGGTGGCCAACGCCATCCGGCTGCAGCGTTCAGGCCTGAGCAACCCG AACCAACCGCCGAGCTTCCTGTTCTGCGGTCCGTCGGGCACGGGCAAGACGCTGCTGACCAAGGCACTGGCCGAG TTCCTGTTCGACGACGCCAAGGCCATGATCCGGTTTGACATGTCGGAGTATCAGGAGCGGCACGCGCTGAGCCGC ATGATCGGGGCACCGCCCGGCTACGTCGGACACGATTCGGGCGGCCAGCTGACGGAGGCATTGCGGAGGCGGCCC TTTTCCATCCTCTTGTTCGACGAGGTTGAGAAGGCGGCCAAGGAGGTGTTGACGGTTCTGCTGCAGCTGATGGAC GACGGCCGGATCACGGATGGCCAAGGCCGGGTGGTGGACGCAAAGAACTGTATCGTCGTCATGACGTCCAATCTC GGAGCCGAGTTCCTGACGAGGCCCGGGGCACGTGAAGGCAAGGTGGACGGTCCGACGCGGGAGCTGGTGATGAAC GCGCTGCGCAACTACTTCTTGCCCGAGTTCCTGAACCGCATCAACTCGGTCGTCATCTTCAACCGGCTGACGCGG CGGGAGATTCGCAAGATTGTCGACCTGCGCTTGACCGAGATCCAGAGGCGGCTCGAGGACAATGGGCGCAAGGTG CGGATCGAGGTCTCGGACGAGGCCAAGGACTATCTGGGCAGCTCGGGATACTCGCCGGCGTACGGGGCACGGCCG TTGGCGCGGCTGATTGAGAAGGAGGTGCTGAACCGGCTGGCCATCCTGATTCTGCGCAACAATGTGCGTGACGGC GAGATTGCCAGGGTCGAGCTCGACGACGGGAAGATTGTGGTGTTGTCGAATCATCCTGATAGCGAGATGGGCGAG GACGAGGACATGATGGATGACGATGACGATGCGGTGGATGAGGTGGTTGGCGAAAATATGGATGAGGATATCTAT AACTAG
Transcript	>Ophcf2|01908 ATGAACGCCCGCATGGACTTCACCGATAGGGCGCAGAAAGCCGTCGAGGACTCCATGGCCCTCGCCGAGCAATAC GCGCACTCGCAGCTTCTCCCCGTTCACCTGGCTGTCGCCCTTCTCGACCCCCCCGTCGATCAGTCCAAGGACCAG CAGAATGGTCCGTCTCAGACCAATGTCACCCTCTTCAGACAGGTCGTCGAGAGGGCCCGCGGCGATCCGCAGCTC TTCGATCGCGCGCTCAAGAAGATGCTCGTCCGGCTTCCGAGCCAGGACCCTCCGCCTGAGCACATCTCGCCCTCA CCATCATACCACGCCGTCCTGCGCAAGGCAATGGAGCTGCAAAAGGTTCAGAAGGATACCTTTATTGGCGTCGAC CACCTCATTACTGCCTTGTCCGAAGACAGCAATATTCAGCAGGCTCTGAGGGACAGCAACATCCCCAAAGCCAAG CTGATGCAGGATGCTGTCCAGGCTATCCGCGGCACCAAGCGCGTCGACAGCAAGACGGCCGACACGGAGCAGGAG AACGAGAACCTGGCCAAGTTTACCATCGACATGACAGCCATGGCCCGCGATAAGAAGATTGATCCCGTCATTGGA AGGGAGGAGGAGATTCGTCGCGTCGTGCGCATCCTATCTCGACGCACCAAGAACAACCCGGTCCTCATTGGCGAG CCAGGTGTCGGCAAGACAACCGTGGTCGAGGGCCTGGCGCAGCGCATCGTCAACCGGGACGTGCCCGACAACCTC AAACACTGCAAGCTCCTTTCGCTCGATGTCGGCGCTCTCGTCGCCGGCAGCAAGTACCGCGGCGAGTTTGAGGAA CGGATGAAGGGTGTACTCAAAGAGATTGAGGACTCCACAGAGATGATTGTCCTCTTCGTGGACGAGATCCATCTA CTCATGGGTGCCGGCTCTTCCGGCGAGGGAGGCATGGACGCTGCCAACCTGCTCAAGCCCATGCTCGCCCGCGGC CAGCTTCATTGCATCGGCGCCACGACGCTGGCCGAGTATCGGAAGTACGTGGAAAAGGACGCCGCGTTTGAGCGT CGCTTCCAACAAGTCATGGTCAAGGAGCCCACCATCCCCGAGACCATTTCCATCCTGCGAGGCCTCAAAGAACGC TACGACCGCCATCATCGCGTCACTATCCTCGACAGCGCCTTGGTGGCCGCTGCGAACCTGGCCGCGCGCTACTTG ACGTCGAGGCGCATGCCCGACTCGGCTATTGACCTGGTGGACGAGGCGGCGGCTGCCGTGCGGGTGGCGCGAGAG TCGCAGCCCGAGATTATCGATTCGCTCGACCGGAAACTGCGGCAGCTGATGATCGAAATCGCCGCGTTGGAGAAG GAACAAGATGAGGCGTCCAAGACGCGGCTGCAACAGGCCAGGAAGGACGCCCAAAACGTCGAGGAGGAGCTTGAG CCTCTCCGGGAGAAATACCAAAACGAGATCAAGAGGGGCGAGGAGATTCACCAAGCCAAGCTCAAGCTCGACGAC CTCGAGAAGCGACTGGAAGACGCGACCAACAACGGAGAGCACGCCAAGGCGGCCGACATCAAGTACGGTGCCATC CCCGAGCAGGAGGCCGTCATTCACGAGCTCGAGGCCCGCAAGGCGGCCGCCGACGCGGCTCTCAACGCGACGGGC GCTGATAGCGGCGGCTCCATGATTACCGACGTCGTCACGGCCGACCACATCAACGAGATTGTCGCCCGCTGGACC GGCATCCCCGTGACGCGGCTGAGGACGTCGGAGAAGGAGAAGCTGGTCAACATGGAAAAGGTGCTGGGAAAGGTG GTGGTGGGCCAGAAGGAGGCGGTCCAGTCGGTGGCCAACGCCATCCGGCTGCAGCGTTCAGGCCTGAGCAACCCG AACCAACCGCCGAGCTTCCTGTTCTGCGGTCCGTCGGGCACGGGCAAGACGCTGCTGACCAAGGCACTGGCCGAG TTCCTGTTCGACGACGCCAAGGCCATGATCCGGTTTGACATGTCGGAGTATCAGGAGCGGCACGCGCTGAGCCGC ATGATCGGGGCACCGCCCGGCTACGTCGGACACGATTCGGGCGGCCAGCTGACGGAGGCATTGCGGAGGCGGCCC TTTTCCATCCTCTTGTTCGACGAGGTTGAGAAGGCGGCCAAGGAGGTGTTGACGGTTCTGCTGCAGCTGATGGAC GACGGCCGGATCACGGATGGCCAAGGCCGGGTGGTGGACGCAAAGAACTGTATCGTCGTCATGACGTCCAATCTC GGAGCCGAGTTCCTGACGAGGCCCGGGGCACGTGAAGGCAAGGTGGACGGTCCGACGCGGGAGCTGGTGATGAAC GCGCTGCGCAACTACTTCTTGCCCGAGTTCCTGAACCGCATCAACTCGGTCGTCATCTTCAACCGGCTGACGCGG CGGGAGATTCGCAAGATTGTCGACCTGCGCTTGACCGAGATCCAGAGGCGGCTCGAGGACAATGGGCGCAAGGTG CGGATCGAGGTCTCGGACGAGGCCAAGGACTATCTGGGCAGCTCGGGATACTCGCCGGCGTACGGGGCACGGCCG TTGGCGCGGCTGATTGAGAAGGAGGTGCTGAACCGGCTGGCCATCCTGATTCTGCGCAACAATGTGCGTGACGGC GAGATTGCCAGGGTCGAGCTCGACGACGGGAAGATTGTGGTGTTGTCGAATCATCCTGATAGCGAGATGGGCGAG GACGAGGACATGATGGATGACGATGACGATGCGGTGGATGAGGTGGTTGGCGAAAATATGGATGAGGATATCTAT AACTAG
Gene	>Ophcf2|01908 ATGAACGCCCGCATGGACTTCACCGATAGGGCGCAGAAAGCCGTCGAGGACTCCATGGCCCTCGCCGAGCAATAC GCGCACTCGCAGCTTCTCCCCGTTCACCTGGCTGTCGCCCTTCTCGACCCCCCCGTCGATCAGTCCAAGGACCAG CAGAATGGTCCGTCTCAGACCAATGTCACCCTCTTCAGACAGGTCGTCGAGAGGGCCCGCGGCGATCCGCAGCTC TTCGATCGCGCGCTCAAGAAGATGCTCGTCCGGCTTCCGAGCCAGGACCCTCCGCCTGAGCACATCTCGCCCTCA CCATCATACCACGCCGTCCTGCGCAAGGCAATGGAGCTGCAAAAGGTTCAGAAGGATACCTTTATTGGCGTCGAC CACCTCATTACTGCCTTGTCCGAAGACAGCAATATTCAGCAGGCTCTGAGGGACAGCAACATCCCCAAAGCCAAG CTGATGCAGGATGCTGTCCAGGCTATCCGCGGCACCAAGCGCGTCGACAGCAAGACGGCCGACACGGAGCAGGAG AACGAGAACCTGGCCAAGTTTACCATCGACATGACAGCCATGGCCCGCGATAAGAAGATTGATCCCGTCATTGGA AGGGAGGAGGAGATTCGTCGCGTCGTGCGCATCCTATCTCGACGCACCAAGAACAACCCGGTCCTCATTGGCGAG CCAGGTGTCGGCAAGACAACCGTGGTCGAGGGCCTGGCGCAGCGCATCGTCAACCGGGACGTGCCCGACAACCTC AAACACTGCAAGCTCCTTTCGCTCGATGTCGGCGCTCTCGTCGCCGGCAGCAAGTACCGCGGCGAGTTTGAGGAA CGGATGAAGGGTGTACTCAAAGAGATTGAGGACTCCACAGAGATGATTGTCCTCTTCGTGGACGAGATCCATCTA CTCATGGGTGCCGGCTCTTCCGGCGAGGGAGGCATGGACGCTGCCAACCTGCTCAAGCCCATGCTCGCCCGCGGC CAGCTTCATTGCATCGGCGCCACGACGCTGGCCGAGTATCGGAAGTACGTGGAAAAGGACGCCGCGTTTGAGCGT CGCTTCCAACAAGTCATGGTCAAGGAGCCCACCATCCCCGAGACCATTTCCATCCTGCGAGGCCTCAAAGAACGC TACGACCGCCATCATCGCGTCACTATCCTCGACAGCGCCTTGGTGGCCGCTGCGAACCTGGCCGCGCGCTACTTG ACGTCGAGGCGCATGCCCGACTCGGCTATTGACCTGGTGGACGAGGCGGCGGCTGCCGTGCGGGTGGCGCGAGAG TCGCAGCCCGAGATTATCGATTCGCTCGACCGGAAACTGCGGCAGCTGATGATCGAAATCGCCGCGTTGGAGAAG GAACAAGATGAGGCGTCCAAGACGCGGCTGCAACAGGCCAGGAAGGACGCCCAAAACGTCGAGGAGGAGCTTGAG CCTCTCCGGGAGAAATACCAAAACGAGATCAAGAGGGGCGAGGAGATTCACCAAGCCAAGCTCAAGCTCGACGAC CTCGAGAAGCGACTGGAAGACGCGACCAACAACGGAGAGCACGCCAAGGCGGCCGACATCAAGTACGGTGCCATC CCCGAGCAGGAGGCCGTCATTCACGAGCTCGAGGCCCGCAAGGCGGCCGCCGACGCGGCTCTCAACGCGACGGGC GCTGATAGCGGCGGCTCCATGATTACCGACGTCGTCACGGCCGACCACATCAACGAGATTGTCGCCCGCTGGACC GGCATCCCCGTGACGCGGCTGAGGACGTCGGAGAAGGAGAAGCTGGTCAACATGGAAAAGGTGCTGGGAAAGGTG GTGGTGGGCCAGAAGGAGGCGGTCCAGTCGGTGGCCAACGCCATCCGGCTGCAGCGTTCAGGCCTGAGCAACCCG AACCAACCGCCGAGCTTCCTGTTCTGCGGTCCGTCGGGCACGGGCAAGACGCTGCTGACCAAGGCACTGGCCGAG TTCCTGTTCGACGACGCCAAGGCCATGATCCGGTTTGACATGTCGGAGTATCAGGAGCGGCACGCGCTGAGCCGC ATGATCGGGGCACCGCCCGGCTACGTCGGACACGATTCGGGCGGCCAGCTGACGGAGGCATTGCGGAGGCGGCCC TTTTCCATCCTCTTGTTCGACGAGGTTGAGAAGGCGGCCAAGGAGGTGTTGACGGTTCTGCTGCAGCTGATGGAC GACGGCCGGATCACGGATGGCCAAGGCCGGGTGGTGGACGCAAAGAACTGTATCGTCGTCATGACGTCCAATCTC GGAGCCGAGTTCCTGACGAGGCCCGGGGCACGTGAAGGCAAGGTGGACGGTCCGACGCGGGAGCTGGTGATGAAC GCGCTGCGCAACTACTTCTTGCCCGAGTTCCTGAACCGCATCAACTCGGTCGTCATCTTCAACCGGCTGACGCGG CGGGAGATTCGCAAGATTGTCGACCTGCGCTTGACCGAGATCCAGAGGCGGCTCGAGGACAATGGGCGCAAGGTG CGGATCGAGGTCTCGGACGAGGCCAAGGACTATCTGGGCAGCTCGGGATACTCGCCGGCGTACGGGGCACGGCCG TTGGCGCGGCTGATTGAGAAGGAGGTGCTGAACCGGCTGGCCATCCTGATTCTGCGCAACAATGTGCGTGACGGC GAGATTGCCAGGGTCGAGCTCGACGACGGGAAGATTGTGGTGTTGTCGAATCATCCTGATAGCGAGATGGGCGAG GACGAGGACATGATGGATGACGATGACGATGCGGTGGATGAGGTGGTTGGCGAAAATATGGATGAGGATATCTAT AACTAG