© 2022 - Robin Ohm - Utrecht University - The Netherlands
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| Protein ID | OphauG2|6870 |
| Gene name | |
| Location | Contig_746:360..1464 |
| Strand | + |
| Gene length (bp) | 1104 |
| Transcript length (bp) | 1104 |
| Coding sequence length (bp) | 1104 |
| Protein length (aa) | 368 |
| PFAM Domain ID | Short name | Long name | E-value | Start | End |
|---|---|---|---|---|---|
| PF01073 | 3Beta_HSD | 3-beta hydroxysteroid dehydrogenase/isomerase family | 3.7E-48 | 13 | 280 |
| PF01370 | Epimerase | NAD dependent epimerase/dehydratase family | 1.4E-24 | 12 | 234 |
| PF16363 | GDP_Man_Dehyd | GDP-mannose 4,6 dehydratase | 2.3E-12 | 13 | 229 |
| PF02719 | Polysacc_synt_2 | Polysaccharide biosynthesis protein | 9.5E-08 | 12 | 123 |
| Swissprot ID | Swissprot Description | Start | End | E-value |
|---|---|---|---|---|
| sp|P53199|ERG26_YEAST | Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ERG26 PE=1 SV=1 | 9 | 357 | 2.0E-44 |
| sp|O43050|ERG26_SCHPO | Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=erg26 PE=3 SV=1 | 7 | 357 | 3.0E-42 |
| sp|Q67ZE1|HSDD2_ARATH | 3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 2 OS=Arabidopsis thaliana GN=3BETAHSD/D2 PE=2 SV=2 | 13 | 351 | 5.0E-42 |
| sp|Q3ZBE9|NSDHL_BOVIN | Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating OS=Bos taurus GN=NSDHL PE=2 SV=1 | 14 | 351 | 2.0E-41 |
| sp|Q9R1J0|NSDHL_MOUSE | Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating OS=Mus musculus GN=Nsdhl PE=1 SV=1 | 14 | 367 | 2.0E-40 |
| Swissprot ID | Swissprot Description | Start | End | E-value |
|---|---|---|---|---|
| sp|P53199|ERG26_YEAST | Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ERG26 PE=1 SV=1 | 9 | 357 | 2.0E-44 |
| sp|O43050|ERG26_SCHPO | Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=erg26 PE=3 SV=1 | 7 | 357 | 3.0E-42 |
| sp|Q67ZE1|HSDD2_ARATH | 3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 2 OS=Arabidopsis thaliana GN=3BETAHSD/D2 PE=2 SV=2 | 13 | 351 | 5.0E-42 |
| sp|Q3ZBE9|NSDHL_BOVIN | Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating OS=Bos taurus GN=NSDHL PE=2 SV=1 | 14 | 351 | 2.0E-41 |
| sp|Q9R1J0|NSDHL_MOUSE | Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating OS=Mus musculus GN=Nsdhl PE=1 SV=1 | 14 | 367 | 2.0E-40 |
| sp|Q9FX01|HSDD1_ARATH | 3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 1 OS=Arabidopsis thaliana GN=3BETAHSD/D1 PE=2 SV=1 | 13 | 351 | 3.0E-40 |
| sp|Q15738|NSDHL_HUMAN | Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating OS=Homo sapiens GN=NSDHL PE=1 SV=2 | 14 | 365 | 3.0E-39 |
| sp|Q5PPL3|NSDHL_RAT | Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating OS=Rattus norvegicus GN=Nsdhl PE=2 SV=1 | 14 | 367 | 7.0E-37 |
| sp|A9X4U2|HSDD3_ARATH | 3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 3 OS=Arabidopsis thaliana GN=3BETAHSD/D3 PE=2 SV=2 | 1 | 358 | 1.0E-35 |
| sp|Q0IH73|D42E1_XENLA | Short-chain dehydrogenase/reductase family 42E member 1 OS=Xenopus laevis GN=sdr42e1 PE=2 SV=1 | 3 | 367 | 7.0E-28 |
| sp|Q4R7R1|D42E1_MACFA | Short-chain dehydrogenase/reductase family 42E member 1 OS=Macaca fascicularis GN=SDR42E1 PE=2 SV=1 | 12 | 362 | 6.0E-26 |
| sp|Q8WUS8|D42E1_HUMAN | Short-chain dehydrogenase/reductase family 42E member 1 OS=Homo sapiens GN=SDR42E1 PE=2 SV=2 | 12 | 362 | 8.0E-26 |
| sp|A8DZE7|D42E1_DANRE | Short-chain dehydrogenase/reductase family 42E member 1 OS=Danio rerio GN=sdr42e1 PE=2 SV=1 | 13 | 366 | 2.0E-25 |
| sp|Q9D665|D42E1_MOUSE | Short-chain dehydrogenase/reductase family 42E member 1 OS=Mus musculus GN=Sdr42e1 PE=1 SV=1 | 12 | 362 | 6.0E-25 |
| sp|Q32L94|D42E1_BOVIN | Short-chain dehydrogenase/reductase family 42E member 1 OS=Bos taurus GN=SDR42E1 PE=2 SV=2 | 12 | 366 | 1.0E-24 |
| sp|P9WQP7|3BHS_MYCTU | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) GN=Rv1106c PE=1 SV=1 | 2 | 358 | 2.0E-21 |
| sp|P9WQP6|3BHS_MYCTO | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase OS=Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) GN=MT1137 PE=3 SV=1 | 2 | 358 | 2.0E-21 |
| sp|P26150|3BHS3_MOUSE | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 3 OS=Mus musculus GN=Hsd3b3 PE=1 SV=3 | 13 | 357 | 7.0E-21 |
| sp|P26149|3BHS2_MOUSE | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 OS=Mus musculus GN=Hsd3b2 PE=1 SV=4 | 13 | 357 | 2.0E-19 |
| sp|O35469|3BHS6_MOUSE | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 6 OS=Mus musculus GN=Hsd3b6 PE=1 SV=4 | 13 | 357 | 1.0E-18 |
| sp|Q62878|3BHS4_RAT | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4 OS=Rattus norvegicus GN=Hsd3b6 PE=2 SV=4 | 13 | 357 | 2.0E-18 |
| sp|P24815|3BHS1_MOUSE | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 OS=Mus musculus GN=Hsd3b1 PE=1 SV=3 | 13 | 357 | 8.0E-17 |
| sp|P22071|3BHS1_RAT | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 OS=Rattus norvegicus GN=Hsd3b1 PE=2 SV=3 | 13 | 357 | 2.0E-16 |
| sp|P22072|3BHS2_RAT | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 OS=Rattus norvegicus GN=Hsd3b PE=2 SV=3 | 13 | 357 | 3.0E-16 |
| sp|Q9EQC1|3BHS7_MOUSE | 3 beta-hydroxysteroid dehydrogenase type 7 OS=Mus musculus GN=Hsd3b7 PE=1 SV=1 | 13 | 357 | 5.0E-15 |
| sp|Q9H2F3|3BHS7_HUMAN | 3 beta-hydroxysteroid dehydrogenase type 7 OS=Homo sapiens GN=HSD3B7 PE=1 SV=2 | 13 | 346 | 2.0E-14 |
| sp|Q64421|3BHS2_MESAU | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 OS=Mesocricetus auratus GN=HSD3B2 PE=2 SV=3 | 13 | 357 | 4.0E-14 |
| sp|Q60555|3BHS1_MESAU | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 OS=Mesocricetus auratus GN=HSD3B1 PE=2 SV=3 | 13 | 357 | 5.0E-13 |
| sp|Q6GZS4|052L_FRG3G | Uncharacterized protein 052L OS=Frog virus 3 (isolate Goorha) GN=FV3-052L PE=3 SV=1 | 13 | 343 | 2.0E-12 |
| sp|Q5IFP1|3BHS_CANLF | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase OS=Canis lupus familiaris GN=HSD3B PE=2 SV=3 | 13 | 357 | 3.0E-12 |
| sp|P14893|3BHS_BOVIN | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase OS=Bos taurus GN=HSD3B PE=1 SV=2 | 13 | 357 | 5.0E-12 |
| sp|P26670|3BHS_VACCW | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase OS=Vaccinia virus (strain Western Reserve) GN=VACWR170 PE=3 SV=1 | 14 | 357 | 5.0E-12 |
| sp|O57245|3BHS_VACCA | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase OS=Vaccinia virus (strain Ankara) GN=MVA157L PE=3 SV=1 | 14 | 357 | 8.0E-12 |
| sp|P55584|Y4NL_RHISN | Uncharacterized protein y4nL OS=Rhizobium sp. (strain NGR234) GN=NGR_a02300 PE=3 SV=1 | 6 | 363 | 9.0E-12 |
| sp|P27364|3BHS5_RAT | 3 beta-hydroxysteroid dehydrogenase type 5 OS=Rattus norvegicus GN=Hsd3b5 PE=2 SV=3 | 13 | 357 | 9.0E-12 |
| sp|P27365|3BHS1_MACMU | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 OS=Macaca mulatta GN=HSD3B1 PE=2 SV=2 | 13 | 367 | 1.0E-11 |
| sp|P21097|3BHS_VACCC | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase OS=Vaccinia virus (strain Copenhagen) GN=A44L PE=3 SV=1 | 14 | 357 | 1.0E-11 |
| sp|P73212|DFRA_SYNY3 | Putative dihydroflavonol-4-reductase OS=Synechocystis sp. (strain PCC 6803 / Kazusa) GN=dfrA PE=3 SV=1 | 13 | 365 | 1.0E-10 |
| sp|P14060|3BHS1_HUMAN | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 OS=Homo sapiens GN=HSD3B1 PE=1 SV=2 | 13 | 367 | 2.0E-10 |
| sp|O35048|3BHS7_RAT | 3 beta-hydroxysteroid dehydrogenase type 7 OS=Rattus norvegicus GN=Hsd3b7 PE=2 SV=1 | 13 | 359 | 2.0E-10 |
| sp|A6NKP2|D42E2_HUMAN | Putative short-chain dehydrogenase/reductase family 42E member 2 OS=Homo sapiens GN=SDR42E2 PE=3 SV=3 | 12 | 343 | 7.0E-10 |
| sp|O46516|3BHS_HORSE | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase OS=Equus caballus GN=HSD3B PE=2 SV=3 | 13 | 357 | 1.0E-09 |
| sp|Q67477|3BHS_FOWPN | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase OS=Fowlpox virus (strain NVSL) GN=FPV046 PE=3 SV=2 | 13 | 359 | 1.0E-09 |
| sp|Q54L85|NSDHL_DICDI | Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating OS=Dictyostelium discoideum GN=nsdhl PE=3 SV=1 | 9 | 351 | 2.0E-09 |
| sp|Q61767|3BHS4_MOUSE | 3 beta-hydroxysteroid dehydrogenase type 4 OS=Mus musculus GN=Hsd3b4 PE=1 SV=3 | 13 | 357 | 1.0E-08 |
| sp|Q61694|3BHS5_MOUSE | 3 beta-hydroxysteroid dehydrogenase type 5 OS=Mus musculus GN=Hsd3b5 PE=1 SV=4 | 13 | 357 | 2.0E-06 |
| GO Term | Description | Terminal node |
|---|---|---|
| GO:0003854 | 3-beta-hydroxy-delta5-steroid dehydrogenase activity | Yes |
| GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | Yes |
| GO:0006694 | steroid biosynthetic process | Yes |
| GO:1901576 | organic substance biosynthetic process | No |
| GO:1901362 | organic cyclic compound biosynthetic process | No |
| GO:0044238 | primary metabolic process | No |
| GO:0008610 | lipid biosynthetic process | No |
| GO:0033764 | steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | No |
| GO:0008150 | biological_process | No |
| GO:0008152 | metabolic process | No |
| GO:0009058 | biosynthetic process | No |
| GO:1901360 | organic cyclic compound metabolic process | No |
| GO:0071704 | organic substance metabolic process | No |
| GO:0003674 | molecular_function | No |
| GO:0008202 | steroid metabolic process | No |
| GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors | No |
| GO:0016229 | steroid dehydrogenase activity | No |
| GO:0003824 | catalytic activity | No |
| GO:0016491 | oxidoreductase activity | No |
| GO:0006629 | lipid metabolic process | No |
| SignalP signal predicted | Location (based on Ymax) |
D score (significance: > 0.45) |
|---|---|---|
| No | 1 - 29 | 0.45 |
| Domain # | Start | End | Length |
|---|---|---|---|
| 1 | 287 | 309 | 22 |
| Type of sequence | Sequence |
|---|---|
| Locus | Download genbank file of locus
The gene with 5 kb flanks (if sufficient flanking sequence is available). For use in cloning design programs. NOTE: features (genes or exons) that are only partially contained within the sequence are completely excluded. |
| Protein | >OphauG2|6870 MESDSTMSLSPVLVTGGCGFIGFHLVQALVASDPNCRVHVLDIQTDINRVHGVTYHTGDVSSLRQVKDAFAAAAP KTVFHMACPKATSQLPEAEYRKACITGTQNTLQAAGDAAVQAFVFTATSSLIHDHKSDMFDGDESWPILKYPDQT CSYSLAKVEAEYEIRAANRRYGGMLTASIWPATAFGPRDSVFTVKVLDSARAGRANIQIGPGTNLYNVTYVSNVA DVHILAAQALVRAYAKPPLPRQERIEGEAFIVTNDETVNFWDFQRAIAASAGYPVKPKDIRVVPIWLAMLLAGIG EWITWALTLGRRKPAYSRWALRLTTINRTLKCDKAKRLLGYKPKISIDQGLAISGQWYKNKGDVKKD* |
| Coding | >OphauG2|6870 ATGGAGAGCGATAGCACCATGTCGCTCAGTCCCGTCCTCGTCACGGGCGGCTGTGGATTCATTGGATTCCATCTC GTGCAGGCACTGGTGGCCAGCGACCCCAACTGCCGGGTCCACGTGCTCGACATTCAAACCGACATCAACCGTGTG CACGGCGTCACATACCACACGGGCGACGTCTCGAGTCTGCGCCAGGTCAAGGATGCGTTTGCAGCGGCAGCGCCC AAGACAGTGTTCCACATGGCCTGCCCCAAGGCGACGAGCCAGCTGCCCGAGGCCGAGTACCGCAAGGCGTGCATC ACGGGCACGCAAAATACTCTGCAAGCAGCTGGAGACGCGGCGGTGCAGGCCTTTGTCTTTACAGCCACGTCGTCG CTGATCCACGACCACAAGTCGGACATGTTTGACGGCGACGAAAGCTGGCCCATCCTCAAGTACCCCGACCAGACG TGTTCCTACAGCCTGGCCAAGGTGGAGGCCGAATACGAGATCCGGGCCGCCAACCGTCGCTACGGCGGCATGCTG ACCGCGTCCATCTGGCCGGCAACCGCGTTTGGCCCTCGCGACAGCGTCTTTACGGTTAAGGTTTTGGACAGCGCG CGAGCGGGCCGAGCAAACATCCAGATCGGGCCGGGAACCAATCTGTACAACGTGACATATGTGAGCAACGTTGCC GACGTCCATATTCTGGCGGCGCAGGCGCTTGTGCGTGCGTATGCGAAGCCGCCGCTGCCACGCCAAGAGCGCATC GAGGGCGAGGCCTTTATCGTCACAAACGACGAAACCGTCAACTTTTGGGACTTTCAACGCGCCATTGCCGCCTCG GCCGGCTATCCCGTCAAGCCCAAGGATATCAGGGTGGTGCCGATTTGGCTGGCCATGCTGCTTGCTGGAATCGGC GAGTGGATAACATGGGCCCTGACGCTGGGCAGACGCAAGCCAGCCTACTCGCGCTGGGCTCTGCGCCTCACCACC ATCAATCGCACCCTGAAATGCGACAAGGCCAAGAGGCTGCTTGGCTACAAGCCCAAGATAAGCATCGACCAAGGC CTGGCTATTTCGGGCCAGTGGTACAAGAATAAAGGCGACGTGAAGAAGGATTGA |
| Transcript | >OphauG2|6870 ATGGAGAGCGATAGCACCATGTCGCTCAGTCCCGTCCTCGTCACGGGCGGCTGTGGATTCATTGGATTCCATCTC GTGCAGGCACTGGTGGCCAGCGACCCCAACTGCCGGGTCCACGTGCTCGACATTCAAACCGACATCAACCGTGTG CACGGCGTCACATACCACACGGGCGACGTCTCGAGTCTGCGCCAGGTCAAGGATGCGTTTGCAGCGGCAGCGCCC AAGACAGTGTTCCACATGGCCTGCCCCAAGGCGACGAGCCAGCTGCCCGAGGCCGAGTACCGCAAGGCGTGCATC ACGGGCACGCAAAATACTCTGCAAGCAGCTGGAGACGCGGCGGTGCAGGCCTTTGTCTTTACAGCCACGTCGTCG CTGATCCACGACCACAAGTCGGACATGTTTGACGGCGACGAAAGCTGGCCCATCCTCAAGTACCCCGACCAGACG TGTTCCTACAGCCTGGCCAAGGTGGAGGCCGAATACGAGATCCGGGCCGCCAACCGTCGCTACGGCGGCATGCTG ACCGCGTCCATCTGGCCGGCAACCGCGTTTGGCCCTCGCGACAGCGTCTTTACGGTTAAGGTTTTGGACAGCGCG CGAGCGGGCCGAGCAAACATCCAGATCGGGCCGGGAACCAATCTGTACAACGTGACATATGTGAGCAACGTTGCC GACGTCCATATTCTGGCGGCGCAGGCGCTTGTGCGTGCGTATGCGAAGCCGCCGCTGCCACGCCAAGAGCGCATC GAGGGCGAGGCCTTTATCGTCACAAACGACGAAACCGTCAACTTTTGGGACTTTCAACGCGCCATTGCCGCCTCG GCCGGCTATCCCGTCAAGCCCAAGGATATCAGGGTGGTGCCGATTTGGCTGGCCATGCTGCTTGCTGGAATCGGC GAGTGGATAACATGGGCCCTGACGCTGGGCAGACGCAAGCCAGCCTACTCGCGCTGGGCTCTGCGCCTCACCACC ATCAATCGCACCCTGAAATGCGACAAGGCCAAGAGGCTGCTTGGCTACAAGCCCAAGATAAGCATCGACCAAGGC CTGGCTATTTCGGGCCAGTGGTACAAGAATAAAGGCGACGTGAAGAAGGATTGA |
| Gene | >OphauG2|6870 ATGGAGAGCGATAGCACCATGTCGCTCAGTCCCGTCCTCGTCACGGGCGGCTGTGGATTCATTGGATTCCATCTC GTGCAGGCACTGGTGGCCAGCGACCCCAACTGCCGGGTCCACGTGCTCGACATTCAAACCGACATCAACCGTGTG CACGGCGTCACATACCACACGGGCGACGTCTCGAGTCTGCGCCAGGTCAAGGATGCGTTTGCAGCGGCAGCGCCC AAGACAGTGTTCCACATGGCCTGCCCCAAGGCGACGAGCCAGCTGCCCGAGGCCGAGTACCGCAAGGCGTGCATC ACGGGCACGCAAAATACTCTGCAAGCAGCTGGAGACGCGGCGGTGCAGGCCTTTGTCTTTACAGCCACGTCGTCG CTGATCCACGACCACAAGTCGGACATGTTTGACGGCGACGAAAGCTGGCCCATCCTCAAGTACCCCGACCAGACG TGTTCCTACAGCCTGGCCAAGGTGGAGGCCGAATACGAGATCCGGGCCGCCAACCGTCGCTACGGCGGCATGCTG ACCGCGTCCATCTGGCCGGCAACCGCGTTTGGCCCTCGCGACAGCGTCTTTACGGTTAAGGTTTTGGACAGCGCG CGAGCGGGCCGAGCAAACATCCAGATCGGGCCGGGAACCAATCTGTACAACGTGACATATGTGAGCAACGTTGCC GACGTCCATATTCTGGCGGCGCAGGCGCTTGTGCGTGCGTATGCGAAGCCGCCGCTGCCACGCCAAGAGCGCATC GAGGGCGAGGCCTTTATCGTCACAAACGACGAAACCGTCAACTTTTGGGACTTTCAACGCGCCATTGCCGCCTCG GCCGGCTATCCCGTCAAGCCCAAGGATATCAGGGTGGTGCCGATTTGGCTGGCCATGCTGCTTGCTGGAATCGGC GAGTGGATAACATGGGCCCTGACGCTGGGCAGACGCAAGCCAGCCTACTCGCGCTGGGCTCTGCGCCTCACCACC ATCAATCGCACCCTGAAATGCGACAAGGCCAAGAGGCTGCTTGGCTACAAGCCCAAGATAAGCATCGACCAAGGC CTGGCTATTTCGGGCCAGTGGTACAAGAATAAAGGCGACGTGAAGAAGGATTGA |