Fungal Genomics

Agaricus bisporus var bisporus H39 Agaricus bisporus var bisporus H97 Agaricus bisporus var burnettii H119p4 Aspergillus niger CBS 112.32 Aspergillus niger CBS 113.50 Aspergillus niger CBS 115988 Aspergillus niger CBS 115989 Aspergillus niger CBS 118.52 Aspergillus niger CBS 124.48 Aspergillus niger CBS 131.52 Aspergillus niger CBS 133816 Aspergillus niger CBS 147320 Aspergillus niger CBS 147321 Aspergillus niger CBS 147322 Aspergillus niger CBS 147323 Aspergillus niger CBS 147324 Aspergillus niger CBS 147343 Aspergillus niger CBS 147344 Aspergillus niger CBS 147345 Aspergillus niger CBS 147346 Aspergillus niger CBS 147347 Aspergillus niger CBS 147352 Aspergillus niger CBS 147353 Aspergillus niger CBS 147371 Aspergillus niger CBS 147482 Aspergillus niger CBS 630.78 Aspergillus niger CBS 769.97 Niveomyces coronatus CBS 149186 Ophiocordyceps australis 1348a (Ghana) Ophiocordyceps australis map64 (Brazil) Ophiocordyceps camponoti-floridani Ophiocordyceps camponoti-rufipedis Ophiocordyceps kimflemingae Ophiocordyceps subramaniannii Penicillium roqueforti DTO002I6 Penicillium roqueforti DTO003C3 Penicillium roqueforti DTO003H1 (CBS 147308) Penicillium roqueforti DTO006G1 Penicillium roqueforti DTO006G7 Penicillium roqueforti DTO012A1 Penicillium roqueforti DTO012A2 (CBS 147309) Penicillium roqueforti DTO012A6 (CBS 147310) Penicillium roqueforti DTO012A7 Penicillium roqueforti DTO012A8 Penicillium roqueforti DTO012A9 Penicillium roqueforti DTO013E5 Penicillium roqueforti DTO013F2 Penicillium roqueforti DTO013F5 (CBS 147311) Penicillium roqueforti DTO027I6 Penicillium roqueforti DTO032C6 Penicillium roqueforti DTO039G3 Penicillium roqueforti DTO046C5 Penicillium roqueforti DTO070G2 (CBS 147317) Penicillium roqueforti DTO081F9 (CBS 147318) Penicillium roqueforti DTO101D6 (CBS 147325) Penicillium roqueforti DTO102I9 (CBS 147326) Penicillium roqueforti DTO126G2 (CBS 147330) Penicillium roqueforti DTO127F7 (CBS 147331) Penicillium roqueforti DTO127F9 (CBS 147332) Penicillium roqueforti DTO130C1 (CBS 147333) Penicillium roqueforti DTO163C3 (CBS 147337) Penicillium roqueforti DTO163F5 (CBS 147338) Penicillium roqueforti DTO163G4 (CBS 147339) Penicillium roqueforti DTO265D5 (CBS 147372) Penicillium roqueforti DTO369A1 (CBS 147354) Penicillium roqueforti DTO375B1 (CBS 147355) Penicillium roqueforti DTO377G2 (LCP 96.3914a) Penicillium roqueforti LCP96 04111 Rhodonia placenta FPRL280 Torrubiellomyces zombiae CBS 149187

General Properties

Protein ID	Hirsu2|527
Gene name
Location	Contig_110:34716..37456
Strand	+
Gene length (bp)	2740
Transcript length (bp)	2592
Coding sequence length (bp)	2592
Protein length (aa)	864

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PFAM Domains

PFAM Domain ID	Short name	Long name	E-value	Start	End
PF00493	MCM	MCM P-loop domain	3.2E-98	476	698
PF17207	MCM_OB	MCM OB domain	1.9E-39	309	435
PF12619	MCM2_N	Mini-chromosome maintenance protein 2	3.0E-34	62	196
PF17855	MCM_lid	MCM AAA-lid domain	7.6E-24	738	820
PF14551	MCM_N	MCM N-terminal domain	1.2E-13	211	301
PF01078	Mg_chelatase	Magnesium chelatase, subunit ChlI	9.8E-06	586	649
PF07728	AAA_5	AAA domain (dynein-related subfamily)	7.6E-06	533	651

Swissprot hits

GO

GO Term	Description	Terminal node
GO:0042555	MCM complex	Yes
GO:1905775	negative regulation of DNA helicase activity	Yes
GO:0006270	DNA replication initiation	Yes
GO:0005634	nucleus	Yes
GO:0003677	DNA binding	Yes
GO:0016887	ATP hydrolysis activity	Yes
GO:0005524	ATP binding	Yes
GO:0032508	DNA duplex unwinding	Yes
GO:0043227	membrane-bounded organelle	No
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	No
GO:0003824	catalytic activity	No
GO:0051097	negative regulation of helicase activity	No
GO:0046483	heterocycle metabolic process	No
GO:0065009	regulation of molecular function	No
GO:0005488	binding	No
GO:0071704	organic substance metabolic process	No
GO:0034641	cellular nitrogen compound metabolic process	No
GO:0017111	nucleoside-triphosphatase activity	No
GO:0044237	cellular metabolic process	No
GO:0006139	nucleobase-containing compound metabolic process	No
GO:0097159	organic cyclic compound binding	No
GO:0008152	metabolic process	No
GO:1901360	organic cyclic compound metabolic process	No
GO:0016462	pyrophosphatase activity	No
GO:0006259	DNA metabolic process	No
GO:0006996	organelle organization	No
GO:0050794	regulation of cellular process	No
GO:0003676	nucleic acid binding	No
GO:0032392	DNA geometric change	No
GO:0030554	adenyl nucleotide binding	No
GO:1901265	nucleoside phosphate binding	No
GO:0035639	purine ribonucleoside triphosphate binding	No
GO:0048519	negative regulation of biological process	No
GO:0044238	primary metabolic process	No
GO:2001251	negative regulation of chromosome organization	No
GO:0000166	nucleotide binding	No
GO:0032553	ribonucleotide binding	No
GO:0003674	molecular_function	No
GO:0051276	chromosome organization	No
GO:0051095	regulation of helicase activity	No
GO:0090304	nucleic acid metabolic process	No
GO:1905463	negative regulation of DNA duplex unwinding	No
GO:0050789	regulation of biological process	No
GO:0071103	DNA conformation change	No
GO:0043167	ion binding	No
GO:0033044	regulation of chromosome organization	No
GO:0043168	anion binding	No
GO:0043170	macromolecule metabolic process	No
GO:0043462	regulation of ATP-dependent activity	No
GO:0097367	carbohydrate derivative binding	No
GO:0017076	purine nucleotide binding	No
GO:1905462	regulation of DNA duplex unwinding	No
GO:0032555	purine ribonucleotide binding	No
GO:0065007	biological regulation	No
GO:0010639	negative regulation of organelle organization	No
GO:0043229	intracellular organelle	No
GO:0044260	cellular macromolecule metabolic process	No
GO:0009987	cellular process	No
GO:0032991	protein-containing complex	No
GO:0032559	adenyl ribonucleotide binding	No
GO:0110165	cellular anatomical entity	No
GO:0048523	negative regulation of cellular process	No
GO:0006725	cellular aromatic compound metabolic process	No
GO:0051128	regulation of cellular component organization	No
GO:0051129	negative regulation of cellular component organization	No
GO:1905774	regulation of DNA helicase activity	No
GO:0005575	cellular_component	No
GO:0043231	intracellular membrane-bounded organelle	No
GO:0050790	regulation of catalytic activity	No
GO:0044092	negative regulation of molecular function	No
GO:0016787	hydrolase activity	No
GO:0071840	cellular component organization or biogenesis	No
GO:0032780	negative regulation of ATP-dependent activity	No
GO:0016817	hydrolase activity, acting on acid anhydrides	No
GO:0008150	biological_process	No
GO:0043226	organelle	No
GO:0043086	negative regulation of catalytic activity	No
GO:0016043	cellular component organization	No
GO:0033043	regulation of organelle organization	No
GO:0036094	small molecule binding	No
GO:1901363	heterocyclic compound binding	No
GO:0006807	nitrogen compound metabolic process	No

SignalP

[Help with interpreting these statistics]

SignalP signal predicted	Location (based on Ymax)	D score (significance: > 0.45)
No	1 - 27	0.45

Transmembrane Domains

(None)

Transcription Factor Class

(None)

Expression data

No expression data available for this genome

Sequences

Type of sequence	Sequence
Locus	Download genbank file of locus The gene with 5 kb flanks (if sufficient flanking sequence is available). For use in cloning design programs. NOTE: features (genes or exons) that are only partially contained within the sequence are completely excluded.
Protein	>Hirsu2|527 MSSPLRDNPASANRGAPPRSNRKRARTGGDDAADLGSSPMPSSPPATPFDMAHGVEDDDEVEEEAEIQDDIDDMD EMADDDIDLFREGFEADYREREGDAYEGDDIDDEGDYDALELGDRRRLEAQLNRRDKEVARRQRIPAAFLPGDDE EGEVDLTTQPRRRRHHYDEDPDEAVDGDIMDEELSLEALGDVKASNLTEWVSLAAVQRTIKREFKAFLTSYTDAS GSSVYGNRIRTLGEINAESLEVSYEHLSESKAILAYFLANAPAEMLKLFDEVAMDVVLLHYPDYERIHSEIHVRV FDLPVHYTLRQLRQSHLNCLVRVSGVVTRRSGVFPQLKYVKFDCSKCGVTLGPFQQESNVEVKISFCQGCQSRGP FTLNSEKTVYRNYQKLTLQESPGTVPAGRLPRHREVILLWDLIDRAKPGEEIEVTGIYRNNYDAQLNNRNGFPVF ATILEANNVVKAHDQLAGFRLTDEDEQAIRKLSRDANIVDRIVGSMAPSIYGHTDIKTAVALSLFGGVAKTTKGA HHVRGDINVLLLGDPGTAKSQVLKYVEKTAHRAVFATGQGASAVGLTASVRRDPLTSEWTLEGGALVLADRGTCL IDEFDKMNDQDRTSIHEAMEQQTISISKAGIVTTLQARCGIIAAANPLGGRYNSTIPFSANVQLTEPILSRFDVL CVVRDTVEPAEDERLARFIVGSHSRSHPTSTQQQDSMEVEPESQPAETQQASSSSSGEIPQALLRKYILYARERC SPKLYHMDEDKVARLFADMRRESLATGAYPITVRHLEAIIRTSEAFSRMRLSEYCSAQDIDRAIAVTVDSFIGSQ KLSCKKALARAFAKYTLARPAGPKRAGGRRGQPAAVTA*
Coding	>Hirsu2|527 ATGAGCTCCCCTCTTCGGGACAACCCGGCTTCTGCCAACCGGGGTGCGCCTCCGCGATCCAATCGCAAGCGTGCG CGCACCGGCGGCGACGATGCGGCCGATCTGGGCTCGAGCCCGATGCCTTCTTCCCCGCCGGCGACGCCCTTCGAC ATGGCACACGGGGTGGAGGACGACGACGAGGTGGAGGAAGAGGCCGAAATCCAAGACGACATCGATGACATGGAC GAGATGGCCGACGACGACATCGACCTGTTCCGCGAGGGATTCGAGGCCGACTACCGGGAGCGAGAGGGCGACGCG TACGAGGGCGACGACATCGACGACGAGGGCGACTACGACGCCCTCGAGCTCGGCGACAGGAGGCGGCTCGAGGCG CAGCTCAACAGGCGCGACAAGGAGGTGGCGCGGCGGCAGAGGATCCCGGCCGCGTTCCTGCCCGGCGACGACGAG GAGGGCGAGGTGGACCTGACGACGCAGCCTCGGCGGCGGCGGCACCACTACGACGAGGATCCCGACGAGGCCGTG GACGGCGACATCATGGACGAGGAGCTGTCGCTCGAGGCGCTGGGGGACGTCAAGGCGTCGAACCTGACGGAGTGG GTGTCGCTGGCGGCGGTGCAGCGGACCATCAAGCGCGAGTTCAAGGCGTTCCTGACGTCGTACACGGACGCGTCG GGCTCGTCCGTCTACGGCAACCGGATCCGCACGCTGGGCGAGATCAACGCCGAGTCGCTCGAGGTGTCGTACGAG CACCTGTCGGAGAGCAAGGCGATCCTGGCCTACTTCCTGGCCAACGCGCCGGCCGAGATGCTCAAGCTGTTCGAC GAGGTGGCCATGGACGTGGTGCTGCTGCACTACCCGGACTACGAGCGCATCCACTCGGAGATTCACGTGCGCGTC TTCGACCTGCCGGTGCACTACACGCTGCGGCAGCTGCGGCAGTCTCACCTCAACTGCCTGGTGCGGGTCAGCGGC GTGGTGACGCGCCGCAGCGGCGTCTTCCCGCAGCTCAAGTACGTCAAGTTCGACTGCAGCAAGTGCGGCGTCACG CTCGGGCCCTTCCAGCAGGAGTCCAACGTCGAGGTCAAGATCAGCTTCTGCCAGGGCTGCCAGTCGCGCGGGCCC TTCACGCTCAACTCGGAGAAGACGGTCTACCGCAACTACCAGAAGCTGACGCTGCAGGAGTCGCCGGGCACGGTG CCGGCCGGGCGGCTGCCGCGGCACCGCGAGGTCATCCTGCTCTGGGACCTCATCGACCGGGCCAAGCCGGGCGAG GAGATTGAGGTGACGGGCATCTACCGCAACAACTACGACGCGCAGCTCAACAACCGCAACGGCTTCCCCGTCTTC GCCACCATCCTCGAGGCCAACAACGTGGTCAAGGCGCACGACCAGCTGGCCGGCTTCCGGCTAACGGACGAGGAC GAGCAGGCGATCCGCAAGCTGTCGCGCGACGCCAACATCGTCGACCGCATCGTCGGCTCCATGGCGCCCAGCATC TACGGCCACACGGACATCAAGACGGCCGTGGCGCTGTCGCTCTTCGGCGGCGTCGCCAAGACGACCAAGGGCGCC CACCACGTCCGCGGCGACATCAACGTCCTGCTGCTCGGCGACCCGGGCACGGCCAAGTCGCAGGTGCTCAAGTAC GTGGAGAAGACGGCGCACCGGGCCGTCTTCGCGACGGGGCAGGGCGCCAGCGCCGTCGGCCTGACGGCCAGCGTG CGCCGCGACCCGCTGACGAGCGAGTGGACGCTCGAGGGCGGCGCCCTCGTGCTGGCCGACCGCGGCACCTGCCTG ATCGACGAGTTCGACAAGATGAACGACCAGGACCGGACCTCGATCCACGAGGCCATGGAGCAGCAGACCATCTCC ATCTCCAAGGCCGGCATCGTCACGACGCTGCAGGCCCGCTGCGGCATCATCGCCGCCGCCAACCCGCTCGGCGGC CGCTACAACTCCACCATCCCCTTCTCCGCCAACGTCCAGCTGACGGAGCCGATCCTGTCGCGCTTCGACGTCCTG TGCGTCGTCCGCGACACCGTCGAGCCGGCCGAGGACGAGCGCCTGGCCCGCTTCATCGTCGGCTCCCACAGCCGC AGCCACCCGACCTCGACCCAGCAGCAGGACTCGATGGAGGTCGAGCCCGAGTCGCAGCCGGCCGAGACGCAGCAG GCCTCGTCGTCCTCGTCCGGCGAGATCCCGCAGGCCCTGCTGCGCAAGTACATCCTCTACGCGCGCGAGCGCTGC AGCCCCAAGCTGTACCACATGGACGAGGACAAGGTGGCGCGCCTGTTCGCCGACATGCGGCGCGAGTCGCTGGCG ACGGGCGCGTACCCCATCACGGTCCGCCACCTCGAGGCCATCATCCGCACGAGCGAGGCCTTCAGCCGGATGCGG CTGTCCGAGTACTGCTCGGCGCAGGACATCGACCGCGCCATCGCCGTCACCGTCGACAGCTTCATCGGCAGCCAG AAGCTGAGCTGCAAGAAGGCGCTGGCCCGCGCCTTCGCCAAGTACACGCTAGCCCGACCGGCCGGACCCAAGCGC GCCGGCGGCCGACGGGGGCAGCCGGCGGCCGTCACCGCCTAG
Transcript	>Hirsu2|527 ATGAGCTCCCCTCTTCGGGACAACCCGGCTTCTGCCAACCGGGGTGCGCCTCCGCGATCCAATCGCAAGCGTGCG CGCACCGGCGGCGACGATGCGGCCGATCTGGGCTCGAGCCCGATGCCTTCTTCCCCGCCGGCGACGCCCTTCGAC ATGGCACACGGGGTGGAGGACGACGACGAGGTGGAGGAAGAGGCCGAAATCCAAGACGACATCGATGACATGGAC GAGATGGCCGACGACGACATCGACCTGTTCCGCGAGGGATTCGAGGCCGACTACCGGGAGCGAGAGGGCGACGCG TACGAGGGCGACGACATCGACGACGAGGGCGACTACGACGCCCTCGAGCTCGGCGACAGGAGGCGGCTCGAGGCG CAGCTCAACAGGCGCGACAAGGAGGTGGCGCGGCGGCAGAGGATCCCGGCCGCGTTCCTGCCCGGCGACGACGAG GAGGGCGAGGTGGACCTGACGACGCAGCCTCGGCGGCGGCGGCACCACTACGACGAGGATCCCGACGAGGCCGTG GACGGCGACATCATGGACGAGGAGCTGTCGCTCGAGGCGCTGGGGGACGTCAAGGCGTCGAACCTGACGGAGTGG GTGTCGCTGGCGGCGGTGCAGCGGACCATCAAGCGCGAGTTCAAGGCGTTCCTGACGTCGTACACGGACGCGTCG GGCTCGTCCGTCTACGGCAACCGGATCCGCACGCTGGGCGAGATCAACGCCGAGTCGCTCGAGGTGTCGTACGAG CACCTGTCGGAGAGCAAGGCGATCCTGGCCTACTTCCTGGCCAACGCGCCGGCCGAGATGCTCAAGCTGTTCGAC GAGGTGGCCATGGACGTGGTGCTGCTGCACTACCCGGACTACGAGCGCATCCACTCGGAGATTCACGTGCGCGTC TTCGACCTGCCGGTGCACTACACGCTGCGGCAGCTGCGGCAGTCTCACCTCAACTGCCTGGTGCGGGTCAGCGGC GTGGTGACGCGCCGCAGCGGCGTCTTCCCGCAGCTCAAGTACGTCAAGTTCGACTGCAGCAAGTGCGGCGTCACG CTCGGGCCCTTCCAGCAGGAGTCCAACGTCGAGGTCAAGATCAGCTTCTGCCAGGGCTGCCAGTCGCGCGGGCCC TTCACGCTCAACTCGGAGAAGACGGTCTACCGCAACTACCAGAAGCTGACGCTGCAGGAGTCGCCGGGCACGGTG CCGGCCGGGCGGCTGCCGCGGCACCGCGAGGTCATCCTGCTCTGGGACCTCATCGACCGGGCCAAGCCGGGCGAG GAGATTGAGGTGACGGGCATCTACCGCAACAACTACGACGCGCAGCTCAACAACCGCAACGGCTTCCCCGTCTTC GCCACCATCCTCGAGGCCAACAACGTGGTCAAGGCGCACGACCAGCTGGCCGGCTTCCGGCTAACGGACGAGGAC GAGCAGGCGATCCGCAAGCTGTCGCGCGACGCCAACATCGTCGACCGCATCGTCGGCTCCATGGCGCCCAGCATC TACGGCCACACGGACATCAAGACGGCCGTGGCGCTGTCGCTCTTCGGCGGCGTCGCCAAGACGACCAAGGGCGCC CACCACGTCCGCGGCGACATCAACGTCCTGCTGCTCGGCGACCCGGGCACGGCCAAGTCGCAGGTGCTCAAGTAC GTGGAGAAGACGGCGCACCGGGCCGTCTTCGCGACGGGGCAGGGCGCCAGCGCCGTCGGCCTGACGGCCAGCGTG CGCCGCGACCCGCTGACGAGCGAGTGGACGCTCGAGGGCGGCGCCCTCGTGCTGGCCGACCGCGGCACCTGCCTG ATCGACGAGTTCGACAAGATGAACGACCAGGACCGGACCTCGATCCACGAGGCCATGGAGCAGCAGACCATCTCC ATCTCCAAGGCCGGCATCGTCACGACGCTGCAGGCCCGCTGCGGCATCATCGCCGCCGCCAACCCGCTCGGCGGC CGCTACAACTCCACCATCCCCTTCTCCGCCAACGTCCAGCTGACGGAGCCGATCCTGTCGCGCTTCGACGTCCTG TGCGTCGTCCGCGACACCGTCGAGCCGGCCGAGGACGAGCGCCTGGCCCGCTTCATCGTCGGCTCCCACAGCCGC AGCCACCCGACCTCGACCCAGCAGCAGGACTCGATGGAGGTCGAGCCCGAGTCGCAGCCGGCCGAGACGCAGCAG GCCTCGTCGTCCTCGTCCGGCGAGATCCCGCAGGCCCTGCTGCGCAAGTACATCCTCTACGCGCGCGAGCGCTGC AGCCCCAAGCTGTACCACATGGACGAGGACAAGGTGGCGCGCCTGTTCGCCGACATGCGGCGCGAGTCGCTGGCG ACGGGCGCGTACCCCATCACGGTCCGCCACCTCGAGGCCATCATCCGCACGAGCGAGGCCTTCAGCCGGATGCGG CTGTCCGAGTACTGCTCGGCGCAGGACATCGACCGCGCCATCGCCGTCACCGTCGACAGCTTCATCGGCAGCCAG AAGCTGAGCTGCAAGAAGGCGCTGGCCCGCGCCTTCGCCAAGTACACGCTAGCCCGACCGGCCGGACCCAAGCGC GCCGGCGGCCGACGGGGGCAGCCGGCGGCCGTCACCGCCTAG
Gene	>Hirsu2|527 ATGAGGTATGCTTGGCCTTGGCCCATCTGTTTGCTCGGCGGCTGAGACTGACTGCCATTTTTTTTTCTCCCATCG TCTCCAGCTCCCCTCTTCGGGACAACCCGGCTTCTGCCAACCGGGGTGCGCCTCCGCGATCCAATCGCAAGCGTG CGCGCACCGGCGGCGACGATGCGGCCGATCTGGGCTCGAGCCCGATGCCTTCTTCCCCGCCGGCGACGCCCTTCG ACATGGCACACGGGGTGGAGGACGACGACGAGGTGGAGGAAGAGGCCGAAATCCAAGACGACATCGATGACATGG ACGAGATGGCCGACGACGACATCGACCTGTTCCGCGAGGGATTCGAGGCCGACTACCGGGAGCGAGAGGGCGACG CGTACGAGGGCGACGACATCGACGACGAGGGCGACTACGACGCCCTCGAGCTCGGCGACAGGAGGCGGCTCGAGG CGCAGCTCAACAGGCGCGACAAGGAGGTGGCGCGGCGGCAGAGGATCCCGGCCGCGTTCCTGCCCGGCGACGACG AGGAGGGCGAGGTGGACCTGACGACGCAGCCTCGGCGGCGGCGGCACCACTACGACGAGGATCCCGACGAGGCCG TGGACGGCGACATCATGGACGAGGAGCTGTCGCTCGAGGCGCTGGGGGACGTCAAGGCGTCGAACCTGACGGAGT GGGTGTCGCTGGCGGCGGTGCAGCGGACCATCAAGCGCGAGTTCAAGGCGTTCCTGACGTCGTACACGGACGCGT CGGGCTCGTCCGTCTACGGCAACCGGATCCGCACGCTGGGCGAGATCAACGCCGAGTCGCTCGAGGTGTCGTACG AGCACCTGTCGGAGAGCAAGGCGATCCTGGCCTACTTCCTGGCCAACGCGCCGGCCGAGATGCTCAAGCTGTTCG ACGAGGTGGCCATGGACGTGGTGCTGCTGCACTACCCGGACTACGAGCGCATCCACTCGGAGATTCACGTGCGCG TCTTCGACCTGCCGGTGCACTACACGCTGCGGCAGCTGCGGCAGTCTCACCTCAACTGCCTGGTGCGGGTCAGCG GCGTGGTGACGCGCCGCAGCGGCGTCTTCCCGCAGCTCAAGTACGTCAAGTTCGACTGCAGCAAGTGCGGCGTCA CGCTCGGGCCCTTCCAGCAGGAGTCCAACGTCGAGGTCAAGATCAGCTTCTGCCAGGGCTGCCAGTCGCGCGGGC CCTTCACGCTCAACTCGGAGAAGACGGTCTACCGCAACTACCAGAAGCTGACGCTGCAGGAGTCGCCGGGCACGG TGCCGGCCGGGCGGCTGCCGCGGCACCGCGAGGTCATCCTGCTCTGGGACCTCATCGACCGGGCCAAGCCGGGCG AGGAGATTGAGGTGACGGGCATCTACCGCAACAACTACGACGCGCAGCTCAACAACCGCAACGGCTTCCCCGTCT TCGCCACCATCCTCGAGGCCAACAACGTGGTCAAGGCGCACGACCAGCTGGCCGGCTTCCGGCTAACGGACGAGG ACGAGCAGGCGATCCGCAAGCTGTCGCGCGACGCCAACATCGTCGACCGCATCGTCGGCTCCATGGCGCCCAGCA TCTACGGCCACACGGACATCAAGACGGCCGTGGCGCTGTCGCTCTTCGGCGGCGTCGCCAAGACGACCAAGGGCG CCCACCACGTCCGCGGCGACATCAACGTCCTGCTGCTCGGCGACCCGGGCACGGCCAAGTCGCAGGTGCTCAAGT ACGTGGAGAAGACGGCGCACCGGGCCGTCTTCGCGACGGGGCAGGGCGCCAGCGCCGTCGGCCTGACGGCCAGCG TGCGCCGCGACCCGCTGACGAGCGAGTGGACGCTCGAGGGCGGCGCCCTCGTGCTGGCCGACCGCGGCACCTGCC TGATCGACGAGTTCGACAAGATGAACGACCAGGACCGGACCTCGATCCACGAGGCCATGGAGCAGCAGACCATCT CCATCTCCAAGGCCGGCATCGTCACGACGCTGCAGGCCCGCTGCGGCATCATCGCCGCCGCCAACCCGCTCGGCG GCCGCTACAACTCCACCATCCCCTTCTCCGCCAACGTCCAGCTGACGGAGCCGATCCTGTCGCGCTTCGACGTCC TGTGCGTCGTCCGCGACACCGTCGAGCCGGCCGAGGACGAGCGCCTGGCCCGCTTCATCGTCGGCTCCCACAGCC GCAGCCACCCGACCTCGACCCAGCAGCAGGACTCGATGGAGGTCGAGCCCGAGTCGCAGCCGGCCGAGACGCAGC AGGCCTCGTCGTCCTCGTCCGGCGAGATCCCGCAGGCCCTGCTGCGCAAGTACATCCTCTACGCGCGCGAGCGCT GCAGCCCCAAGCTGTACCACATGGACGAGGACAAGGTGGCGCGCCTGTTCGCCGACATGCGGCGCGAGTCGCTGG CGACGGGCGCGTACCCCATCACGGTACGTCCGAGGCCATCATCATCAACCCCCGTCGTCGTCCTTCTCCTCTTGC TGACGCAGCCCCCGCACAGGTCCGCCACCTCGAGGCCATCATCCGCACGAGCGAGGCCTTCAGCCGGATGCGGCT GTCCGAGTACTGCTCGGCGCAGGACATCGACCGCGCCATCGCCGTCACCGTCGACAGCTTCATCGGCAGCCAGAA GCTGAGCTGCAAGAAGGCGCTGGCCCGCGCCTTCGCCAAGTACACGCTAGCCCGACCGGCCGGACCCAAGCGCGC CGGCGGCCGACGGGGGCAGCCGGCGGCCGTCACCGCCTAG