Fungal Genomics

Agaricus bisporus var bisporus H39 Agaricus bisporus var bisporus H97 Agaricus bisporus var burnettii H119p4 Aspergillus niger CBS 112.32 Aspergillus niger CBS 113.50 Aspergillus niger CBS 115988 Aspergillus niger CBS 115989 Aspergillus niger CBS 118.52 Aspergillus niger CBS 124.48 Aspergillus niger CBS 131.52 Aspergillus niger CBS 133816 Aspergillus niger CBS 147320 Aspergillus niger CBS 147321 Aspergillus niger CBS 147322 Aspergillus niger CBS 147323 Aspergillus niger CBS 147324 Aspergillus niger CBS 147343 Aspergillus niger CBS 147344 Aspergillus niger CBS 147345 Aspergillus niger CBS 147346 Aspergillus niger CBS 147347 Aspergillus niger CBS 147352 Aspergillus niger CBS 147353 Aspergillus niger CBS 147371 Aspergillus niger CBS 147482 Aspergillus niger CBS 630.78 Aspergillus niger CBS 769.97 Niveomyces coronatus CBS 149186 Ophiocordyceps australis 1348a (Ghana) Ophiocordyceps australis map64 (Brazil) Ophiocordyceps camponoti-floridani Ophiocordyceps camponoti-rufipedis Ophiocordyceps kimflemingae Ophiocordyceps subramaniannii Penicillium roqueforti DTO002I6 Penicillium roqueforti DTO003C3 Penicillium roqueforti DTO003H1 (CBS 147308) Penicillium roqueforti DTO006G1 Penicillium roqueforti DTO006G7 Penicillium roqueforti DTO012A1 Penicillium roqueforti DTO012A2 (CBS 147309) Penicillium roqueforti DTO012A6 (CBS 147310) Penicillium roqueforti DTO012A7 Penicillium roqueforti DTO012A8 Penicillium roqueforti DTO012A9 Penicillium roqueforti DTO013E5 Penicillium roqueforti DTO013F2 Penicillium roqueforti DTO013F5 (CBS 147311) Penicillium roqueforti DTO027I6 Penicillium roqueforti DTO032C6 Penicillium roqueforti DTO039G3 Penicillium roqueforti DTO046C5 Penicillium roqueforti DTO070G2 (CBS 147317) Penicillium roqueforti DTO081F9 (CBS 147318) Penicillium roqueforti DTO101D6 (CBS 147325) Penicillium roqueforti DTO102I9 (CBS 147326) Penicillium roqueforti DTO126G2 (CBS 147330) Penicillium roqueforti DTO127F7 (CBS 147331) Penicillium roqueforti DTO127F9 (CBS 147332) Penicillium roqueforti DTO130C1 (CBS 147333) Penicillium roqueforti DTO163C3 (CBS 147337) Penicillium roqueforti DTO163F5 (CBS 147338) Penicillium roqueforti DTO163G4 (CBS 147339) Penicillium roqueforti DTO265D5 (CBS 147372) Penicillium roqueforti DTO369A1 (CBS 147354) Penicillium roqueforti DTO375B1 (CBS 147355) Penicillium roqueforti DTO377G2 (LCP 96.3914a) Penicillium roqueforti LCP96 04111 Rhodonia placenta FPRL280 Torrubiellomyces zombiae CBS 149187

General Properties

Protein ID	AgabiH97|065170
Gene name
Location	scaffold_3:3037911..3039746
Strand	+
Gene length (bp)	1835
Transcript length (bp)	1386
Coding sequence length (bp)	1386
Protein length (aa)	462

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PFAM Domains

PFAM Domain ID	Short name	Long name	E-value	Start	End
PF01328	Peroxidase_2	Peroxidase, family 2	2.1E-47	102	319

Swissprot hits

Swissprot ID	Swissprot Description	Start	End	E-value
sp|B9W4V6|APO1_AGRAE	Aromatic peroxygenase OS=Agrocybe aegerita GN=APO1 PE=1 SV=1	46	411	2.0E-127
sp|B9W4V8|APO1_COPRA	Aromatic peroxygenase (Fragments) OS=Coprinellus radians GN=APO PE=1 SV=2	84	317	1.0E-70
sp|Q00668|STCC_EMENI	Putative sterigmatocystin biosynthesis peroxidase stcC OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) GN=stcC PE=3 SV=2	108	312	1.0E-20
sp|P04963|PRXC_LEPFU	Chloroperoxidase OS=Leptoxyphium fumago GN=CPO PE=1 SV=3	103	255	7.0E-07

GO

GO Term	Description	Terminal node
GO:0004601	peroxidase activity	Yes
GO:0003674	molecular_function	No
GO:0016491	oxidoreductase activity	No
GO:0016209	antioxidant activity	No
GO:0003824	catalytic activity	No
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	No

SignalP

[Help with interpreting these statistics]

SignalP signal predicted	Location (based on Ymax)	D score (significance: > 0.45)
No	1 - 55	0.45

Transmembrane Domains

(None)

Transcription Factor Class

(None)

Expression data

Analysis 1: Developmental stages of Agaricus bisporus (strain A15). Published in Pelkmans et al, Applied Microbiology and Biotechnology, 2016

Expression values

Label	Description	Expression (RPKM)	Confidence interval (low)	Confidence interval (high)
Casing	Casing mycelium	24.04	12.09	36.00
Initials	Initials knots	28.67	16.17	41.17
Pileal_Stipeal_center	Stage I stipe center	12.22	6.21	18.23
Pileal_Stipeal_shell	Stage I stipe shell	10.25	5.07	15.44
DIF_stipe_center	Stage II stipe center	12.15	6.19	18.11
DIF_stipe_shell	Stage II stipe shell	11.31	5.67	16.96
DIF_stipe_skin	Stage II stipe skin	11.41	5.66	17.16
DIF_cap_skin	Stage II cap skin	7.74	3.72	11.77
DIF_cap_tissue	Stage II cap tissue	11.06	5.48	16.63
DIF_gill_tissue	Stage II gill tissue	15.66	8.21	23.10
YFB_stipe_center	Young fruiting body stipe center	11.68	5.84	17.52
YFB_stipe_shell	Young fruiting body stipe shell	14.38	7.40	21.37
YFB_stipe_skin	Young fruiting body stipe skin	12.02	6.01	18.03
YFB_cap_skin	Young fruiting body cap skin	5.78	2.65	8.91
YFB_cap_tissue	Young fruiting body cap tissue	17.54	9.27	25.80
YFB_gill_tissue	Young fruiting body gill tissue	8.62	4.15	13.09
YFB_veil	Young fruiting body veil	9.32	4.57	14.08

Differential expression

Label1	Label2	Q-value	Significant difference
Casing	DIF_gill_tissue	0.239533	no
Casing	YFB_stipe_center	0.026955	yes
Casing	YFB_stipe_shell	0.140982	no
Casing	YFB_stipe_skin	0.038942	yes
Casing	YFB_cap_skin	0.000613	yes
Casing	YFB_cap_tissue	0.444210	no
Casing	YFB_gill_tissue	0.001140	yes
Casing	YFB_veil	0.001140	yes
Casing	Initials	0.714470	no
Casing	Pileal_Stipeal_center	0.037140	yes
Casing	Pileal_Stipeal_shell	0.006032	yes
Casing	DIF_stipe_center	0.036228	yes
Casing	DIF_stipe_shell	0.020523	yes
Casing	DIF_stipe_skin	0.019715	yes
Casing	DIF_cap_skin	0.000613	yes
Casing	DIF_cap_tissue	0.015819	yes
DIF_gill_tissue	YFB_stipe_center	0.489381	no
DIF_gill_tissue	YFB_stipe_shell	0.885552	no
DIF_gill_tissue	YFB_stipe_skin	0.546018	no
DIF_gill_tissue	YFB_cap_skin	0.004928	yes
DIF_gill_tissue	YFB_cap_tissue	0.835812	no
DIF_gill_tissue	YFB_gill_tissue	0.078944	no
DIF_gill_tissue	YFB_veil	0.129965	no
YFB_stipe_center	YFB_stipe_shell	0.676018	no
YFB_stipe_center	YFB_stipe_skin	0.967429	no
YFB_stipe_center	YFB_cap_skin	0.052346	no
YFB_stipe_center	YFB_cap_tissue	0.286904	no
YFB_stipe_center	YFB_gill_tissue	0.502008	no
YFB_stipe_center	YFB_veil	0.643140	no
YFB_stipe_shell	YFB_stipe_skin	0.728377	no
YFB_stipe_shell	YFB_cap_skin	0.008791	yes
YFB_stipe_shell	YFB_cap_tissue	0.681460	no
YFB_stipe_shell	YFB_gill_tissue	0.160121	no
YFB_stipe_shell	YFB_veil	0.246714	no
YFB_stipe_skin	YFB_cap_skin	0.040723	yes
YFB_stipe_skin	YFB_cap_tissue	0.333265	no
YFB_stipe_skin	YFB_gill_tissue	0.444861	no
YFB_stipe_skin	YFB_veil	0.586808	no
YFB_cap_skin	YFB_cap_tissue	0.001140	yes
YFB_cap_skin	YFB_gill_tissue	0.353184	no
YFB_cap_skin	YFB_veil	0.219875	no
YFB_cap_tissue	YFB_gill_tissue	0.031088	yes
YFB_cap_tissue	YFB_veil	0.052745	no
YFB_gill_tissue	YFB_veil	0.904571	no
Initials	DIF_gill_tissue	0.044418	yes
Initials	YFB_stipe_center	0.003765	yes
Initials	YFB_stipe_shell	0.022111	yes
Initials	YFB_stipe_skin	0.006387	yes
Initials	YFB_cap_skin	0.000613	yes
Initials	YFB_cap_tissue	0.128955	no
Initials	YFB_gill_tissue	0.000613	yes
Initials	YFB_veil	0.000613	yes
Initials	Pileal_Stipeal_center	0.003765	yes
Initials	Pileal_Stipeal_shell	0.001140	yes
Initials	DIF_stipe_center	0.002951	yes
Initials	DIF_stipe_shell	0.002525	yes
Initials	DIF_stipe_skin	0.001625	yes
Initials	DIF_cap_skin	0.000613	yes
Initials	DIF_cap_tissue	0.000613	yes
Pileal_Stipeal_center	DIF_gill_tissue	0.566038	no
Pileal_Stipeal_center	YFB_stipe_center	0.945387	no
Pileal_Stipeal_center	YFB_stipe_shell	0.749575	no
Pileal_Stipeal_center	YFB_stipe_skin	0.980105	no
Pileal_Stipeal_center	YFB_cap_skin	0.034604	yes
Pileal_Stipeal_center	YFB_cap_tissue	0.344495	no
Pileal_Stipeal_center	YFB_gill_tissue	0.393961	no
Pileal_Stipeal_center	YFB_veil	0.537172	no
Pileal_Stipeal_center	Pileal_Stipeal_shell	0.723535	no
Pileal_Stipeal_center	DIF_stipe_center	0.991714	no
Pileal_Stipeal_center	DIF_stipe_shell	0.900497	no
Pileal_Stipeal_center	DIF_stipe_skin	0.911582	no
Pileal_Stipeal_center	DIF_cap_skin	0.227479	no
Pileal_Stipeal_center	DIF_cap_tissue	0.864562	no
Pileal_Stipeal_shell	DIF_gill_tissue	0.240410	no
Pileal_Stipeal_shell	YFB_stipe_center	0.821022	no
Pileal_Stipeal_shell	YFB_stipe_shell	0.395662	no
Pileal_Stipeal_shell	YFB_stipe_skin	0.769188	no
Pileal_Stipeal_shell	YFB_cap_skin	0.124703	no
Pileal_Stipeal_shell	YFB_cap_tissue	0.115194	no
Pileal_Stipeal_shell	YFB_gill_tissue	0.747497	no
Pileal_Stipeal_shell	YFB_veil	0.875171	no
Pileal_Stipeal_shell	DIF_stipe_center	0.741242	no
Pileal_Stipeal_shell	DIF_stipe_shell	0.872760	no
Pileal_Stipeal_shell	DIF_stipe_skin	0.859949	no
Pileal_Stipeal_shell	DIF_cap_skin	0.536020	no
Pileal_Stipeal_shell	DIF_cap_tissue	0.906448	no
DIF_stipe_center	DIF_gill_tissue	0.557309	no
DIF_stipe_center	YFB_stipe_center	0.953410	no
DIF_stipe_center	YFB_stipe_shell	0.743685	no
DIF_stipe_center	YFB_stipe_skin	0.987027	no
DIF_stipe_center	YFB_cap_skin	0.034837	yes
DIF_stipe_center	YFB_cap_tissue	0.334798	no
DIF_stipe_center	YFB_gill_tissue	0.406524	no
DIF_stipe_center	YFB_veil	0.551286	no
DIF_stipe_center	DIF_stipe_shell	0.912444	no
DIF_stipe_center	DIF_stipe_skin	0.921660	no
DIF_stipe_center	DIF_cap_skin	0.229251	no
DIF_stipe_center	DIF_cap_tissue	0.876147	no
DIF_stipe_shell	DIF_gill_tissue	0.433061	no
DIF_stipe_shell	YFB_stipe_center	0.962723	no
DIF_stipe_shell	YFB_stipe_shell	0.608095	no
DIF_stipe_shell	YFB_stipe_skin	0.926589	no
DIF_stipe_shell	YFB_cap_skin	0.063183	no
DIF_stipe_shell	YFB_cap_tissue	0.240294	no
DIF_stipe_shell	YFB_gill_tissue	0.560937	no
DIF_stipe_shell	YFB_veil	0.703008	no
DIF_stipe_shell	DIF_stipe_skin	0.989379	no
DIF_stipe_shell	DIF_cap_skin	0.363211	no
DIF_stipe_shell	DIF_cap_tissue	0.972996	no
DIF_stipe_skin	DIF_gill_tissue	0.437453	no
DIF_stipe_skin	YFB_stipe_center	0.973827	no
DIF_stipe_skin	YFB_stipe_shell	0.619845	no
DIF_stipe_skin	YFB_stipe_skin	0.938788	no
DIF_stipe_skin	YFB_cap_skin	0.052948	no
DIF_stipe_skin	YFB_cap_tissue	0.238763	no
DIF_stipe_skin	YFB_gill_tissue	0.538888	no
DIF_stipe_skin	YFB_veil	0.683627	no
DIF_stipe_skin	DIF_cap_skin	0.338858	no
DIF_stipe_skin	DIF_cap_tissue	0.964752	no
DIF_cap_skin	DIF_gill_tissue	0.032978	yes
DIF_cap_skin	YFB_stipe_center	0.301086	no
DIF_cap_skin	YFB_stipe_shell	0.072862	no
DIF_cap_skin	YFB_stipe_skin	0.261240	no
DIF_cap_skin	YFB_cap_skin	0.537876	no
DIF_cap_skin	YFB_cap_tissue	0.014081	yes
DIF_cap_skin	YFB_gill_tissue	0.865286	no
DIF_cap_skin	YFB_veil	0.722412	no
DIF_cap_skin	DIF_cap_tissue	0.389072	no
DIF_cap_tissue	DIF_gill_tissue	0.379661	no
DIF_cap_tissue	YFB_stipe_center	0.936594	no
DIF_cap_tissue	YFB_stipe_shell	0.556189	no
DIF_cap_tissue	YFB_stipe_skin	0.897656	no
DIF_cap_tissue	YFB_cap_skin	0.070499	no
DIF_cap_tissue	YFB_cap_tissue	0.196632	no
DIF_cap_tissue	YFB_gill_tissue	0.604851	no
DIF_cap_tissue	YFB_veil	0.744568	no

Sequences

Type of sequence	Sequence
Locus	Download genbank file of locus The gene with 5 kb flanks (if sufficient flanking sequence is available). For use in cloning design programs. NOTE: features (genes or exons) that are only partially contained within the sequence are completely excluded.
Protein	>AgabiH97|065170 MDRTYSRLTLQKPGARHDVGPLRYANFVFAKLYENRKDIKGCLARVALAAPAAAFPAHGSLAGLSRQELDDAMSG FGEYTRPPPPPGPLEYGGVKLVNDADHPFIAPGEGDIRGPCPALNTLANHGYISRNGIESPSNIVRGAMEGFNMN NDLSKFTCYAAFMVNGNLITDLVSIGEKSPKTGPDPKEQPMATIGGLNTHNVFEGDSSMTRADFYDGGDVESFNE TLFQGFIEYSNRFGGGRYNLTAAGQFRLKRIQDGVQHNPTFTIVAPRLFSAYSEAVNPINMWVDGRQDDGQLRLD HARSFFEAARFPDDFHRAARPMSADNEAVVHAIHPIEPGANIAGINTYTVDRNAPRLDDKCGIFEYHVNHTLRTL YPNPTGNLLDAIRANIHYFFTAMEARGCTEIFPYGRFEDGESNNYYATPDYPEVELPELGTLPFPPVELPTYSDP LVDVGPGATTA*
Coding	>AgabiH97|065170 ATGGATCGAACATATTCCCGCCTCACCCTGCAAAAACCGGGTGCGAGGCACGACGTCGGTCCTTTACGGTACGCG AACTTTGTGTTTGCGAAACTGTATGAAAACCGGAAAGATATAAAAGGATGCCTGGCAAGAGTGGCTTTGGCTGCT CCCGCCGCCGCATTCCCAGCTCATGGTTCATTGGCTGGCTTGTCGAGGCAAGAGTTGGACGATGCCATGAGTGGC TTCGGAGAATACACAAGGCCACCGCCACCCCCAGGACCCCTCGAGTACGGTGGTGTTAAACTGGTCAACGATGCC GACCATCCTTTCATCGCTCCGGGTGAAGGCGACATCCGTGGTCCTTGCCCGGCTTTGAACACTCTCGCCAACCAC GGTTACATCAGCCGCAATGGTATTGAGTCACCATCTAACATCGTCCGTGGTGCCATGGAAGGTTTCAACATGAAC AACGACTTGTCCAAGTTCACCTGTTACGCTGCCTTCATGGTCAACGGAAACTTGATCACTGACTTGGTCAGTATC GGTGAGAAGTCCCCGAAGACCGGACCAGACCCAAAAGAACAACCGATGGCGACTATTGGTGGTTTGAACACCCAC AACGTGTTCGAGGGTGACAGTTCTATGACTCGCGCTGATTTCTATGATGGTGGTGATGTCGAGAGCTTCAACGAA ACCCTCTTCCAAGGCTTCATTGAATACAGCAACAGGTTCGGTGGTGGAAGGTACAACCTTACCGCCGCTGGCCAG TTCCGTCTCAAGCGTATCCAAGATGGTGTCCAGCACAACCCGACCTTCACCATCGTCGCTCCCCGACTCTTCTCT GCTTACTCTGAAGCCGTCAACCCGATCAACATGTGGGTCGATGGACGCCAAGATGATGGTCAACTCAGGCTCGAC CATGCCCGCAGCTTCTTCGAAGCCGCCCGTTTCCCCGATGACTTCCACAGGGCCGCACGCCCCATGAGCGCTGAC AACGAGGCCGTTGTACACGCTATCCACCCCATCGAGCCCGGAGCAAACATCGCCGGTATCAACACTTACACTGTT GACCGTAATGCACCCAGACTCGACGACAAGTGCGGTATCTTCGAGTACCACGTCAACCACACTCTCCGCACTCTC TACCCCAACCCGACCGGTAACTTGTTAGACGCCATCAGGGCCAACATCCACTACTTCTTCACCGCTATGGAGGCT AGGGGTTGCACCGAAATCTTCCCTTACGGTAGATTCGAGGATGGCGAAAGCAACAACTACTACGCGACCCCTGAT TACCCCGAAGTCGAGCTCCCCGAGCTAGGAACTCTCCCCTTCCCCCCCGTCGAGCTCCCTACATACTCTGACCCC CTCGTAGACGTCGGTCCCGGAGCCACCACCGCCTAA
Transcript	>AgabiH97|065170 ATGGATCGAACATATTCCCGCCTCACCCTGCAAAAACCGGGTGCGAGGCACGACGTCGGTCCTTTACGGTACGCG AACTTTGTGTTTGCGAAACTGTATGAAAACCGGAAAGATATAAAAGGATGCCTGGCAAGAGTGGCTTTGGCTGCT CCCGCCGCCGCATTCCCAGCTCATGGTTCATTGGCTGGCTTGTCGAGGCAAGAGTTGGACGATGCCATGAGTGGC TTCGGAGAATACACAAGGCCACCGCCACCCCCAGGACCCCTCGAGTACGGTGGTGTTAAACTGGTCAACGATGCC GACCATCCTTTCATCGCTCCGGGTGAAGGCGACATCCGTGGTCCTTGCCCGGCTTTGAACACTCTCGCCAACCAC GGTTACATCAGCCGCAATGGTATTGAGTCACCATCTAACATCGTCCGTGGTGCCATGGAAGGTTTCAACATGAAC AACGACTTGTCCAAGTTCACCTGTTACGCTGCCTTCATGGTCAACGGAAACTTGATCACTGACTTGGTCAGTATC GGTGAGAAGTCCCCGAAGACCGGACCAGACCCAAAAGAACAACCGATGGCGACTATTGGTGGTTTGAACACCCAC AACGTGTTCGAGGGTGACAGTTCTATGACTCGCGCTGATTTCTATGATGGTGGTGATGTCGAGAGCTTCAACGAA ACCCTCTTCCAAGGCTTCATTGAATACAGCAACAGGTTCGGTGGTGGAAGGTACAACCTTACCGCCGCTGGCCAG TTCCGTCTCAAGCGTATCCAAGATGGTGTCCAGCACAACCCGACCTTCACCATCGTCGCTCCCCGACTCTTCTCT GCTTACTCTGAAGCCGTCAACCCGATCAACATGTGGGTCGATGGACGCCAAGATGATGGTCAACTCAGGCTCGAC CATGCCCGCAGCTTCTTCGAAGCCGCCCGTTTCCCCGATGACTTCCACAGGGCCGCACGCCCCATGAGCGCTGAC AACGAGGCCGTTGTACACGCTATCCACCCCATCGAGCCCGGAGCAAACATCGCCGGTATCAACACTTACACTGTT GACCGTAATGCACCCAGACTCGACGACAAGTGCGGTATCTTCGAGTACCACGTCAACCACACTCTCCGCACTCTC TACCCCAACCCGACCGGTAACTTGTTAGACGCCATCAGGGCCAACATCCACTACTTCTTCACCGCTATGGAGGCT AGGGGTTGCACCGAAATCTTCCCTTACGGTAGATTCGAGGATGGCGAAAGCAACAACTACTACGCGACCCCTGAT TACCCCGAAGTCGAGCTCCCCGAGCTAGGAACTCTCCCCTTCCCCCCCGTCGAGCTCCCTACATACTCTGACCCC CTCGTAGACGTCGGTCCCGGAGCCACCACCGCCTAA
Gene	>AgabiH97|065170 ATGGATCGGTATGCTGATAACGTCTAACTATTGGTAAGTCGACAGGGATGATAATATATCGGTAAGGGTCCGCTT ACAACTTAAAACCAAGAACATATTAACCGCATACGTCACTCCCGAATTGATTAATTGATCAAGAACATATTCCCG CCTCACCCTGCAAAAACCGGGTGCGAGGGTATGTCGAGCTGCACTTGATGTCCTATCGCATTCTCACACCCGGTA GCACGACGTCGGTCCTTTACGGTACGCGAACTTTGTGTTTGCGAAACTGTATGAAAACCGGAAAGATATAAAAGG ATGCCTGGCAAGAGGTAAGAAAGATCAGTTCGCTGTTCAGTCATGGTCGGCTTCCTATCCTTCGTTGCGCTCGCA GTGGCTTTGGCTGCTCCCGCCGCCGCATTCCCAGCTCATGGTTCATTGGCTGGCTTGTCGAGGCAAGAGTTGGAC GATGCCATGAGTGGCTTCGGAGAATACACAAGGCCACCGCCACCCCCAGGACCCCTCGAGTACGGTGGTGTTAAA CTGGTCAACGATGCCGACCATCCTTTCATCGCTCCGGGTGAAGGCGACATCCGTGGTCCTTGCCCGGCTTTGAAC ACTCTCGCCAACCACGGTGTACGTACCATTTCTCCAGCTCGCTTCTCGGTAACATCTGACCGCAAATCACAGTAC ATCAGCCGCAATGGTATTGAGTCACCATCTAACATCGTCCGTGGTGCCATGGAAGGTTAGTGCTTCAGGTCTTCC TTCACGTCCTTTCGCTGACTTTGAGCAGGTTTCAACATGAACAACGACTTGTCCAAGTTCACCTGTTACGCTGCC TTCATGGTCAACGGAAACTTGATCACTGACTTGGTCAGTATCGGTGAGAAGTCCCCGAAGACCGGACCAGACCCA AAAGAACAACCGATGGCGACTATTGGTGGTTTGAACACCCACAACGTGTTCGAGGGTGACAGTTCTATGACTCGC GGTGAGTTTCGCGTATCGCCACAGTTATCCCAATCAATTGGCTTACTTTGTCTCCAGCTGATTTCTATGATGGTG GTGATGTCGAGAGCTTCAACGAAACCCTCTTCCAAGGCGTATGTTGTCCTGTATATCTTGAAGCTCCCAGAATCT GATTCTCTTCACAGTTCATTGAATACAGCAACAGGTTCGGTGGTGGAAGGTACAACCTTACCGCCGCTGGCCAGT TCCGTCTCAAGCGTATCCAAGATGGTGTCCAGCACAACCCGACCTTCACCATCGTCGCTCCCCGACTCTTCTCTG CTTACTCTGAAGCCGTCAACCCGATCAACATGTGGGTCGATGGACGCCAAGATGATGGTCAACTCAGGCTCGACC ATGCCCGCAGCTTCTTCGAAGCCGCCCGTTTCCCCGATGACTTCCACAGGGCCGCACGCCCCATGAGCGCTGACA ACGAGGCCGTTGTACACGCTATCCACCCCATCGAGCCCGGAGCAAACATCGCCGGTATCAACACTTACACTGTTG ACCGTAATGCACCCAGACTCGACGACAAGTGCGGTATCTTCGAGTACCACGTCAACCACACTCTCCGCACTCTCT ACCCCAACCCGACCGGTAACTTGTTAGACGCCATCAGGGCCAACATCCACTACTTCTTCACCGCTATGGAGGCTA GGGGTTGCACCGAAATCTTCCCTTACGGTAGATTCGAGGATGGCGAAAGCAACAACTACTACGCGACCCCTGATT ACCCCGAAGTCGAGCTCCCCGAGCTAGGAACTCTCCCCTTCCCCCCCGTCGAGCTCCCTACATACTCTGACCCCC TCGTAGACGTCGGTCCCGGAGCCACCACCGCCTAA