Fungal Genomics

Agaricus bisporus var bisporus H39 Agaricus bisporus var bisporus H97 Agaricus bisporus var burnettii H119p4 Aspergillus niger CBS 112.32 Aspergillus niger CBS 113.50 Aspergillus niger CBS 115988 Aspergillus niger CBS 115989 Aspergillus niger CBS 118.52 Aspergillus niger CBS 124.48 Aspergillus niger CBS 131.52 Aspergillus niger CBS 133816 Aspergillus niger CBS 147320 Aspergillus niger CBS 147321 Aspergillus niger CBS 147322 Aspergillus niger CBS 147323 Aspergillus niger CBS 147324 Aspergillus niger CBS 147343 Aspergillus niger CBS 147344 Aspergillus niger CBS 147345 Aspergillus niger CBS 147346 Aspergillus niger CBS 147347 Aspergillus niger CBS 147352 Aspergillus niger CBS 147353 Aspergillus niger CBS 147371 Aspergillus niger CBS 147482 Aspergillus niger CBS 630.78 Aspergillus niger CBS 769.97 Niveomyces coronatus CBS 149186 Ophiocordyceps australis 1348a (Ghana) Ophiocordyceps australis map64 (Brazil) Ophiocordyceps camponoti-floridani Ophiocordyceps camponoti-rufipedis Ophiocordyceps kimflemingae Ophiocordyceps subramaniannii Penicillium roqueforti DTO002I6 Penicillium roqueforti DTO003C3 Penicillium roqueforti DTO003H1 (CBS 147308) Penicillium roqueforti DTO006G1 Penicillium roqueforti DTO006G7 Penicillium roqueforti DTO012A1 Penicillium roqueforti DTO012A2 (CBS 147309) Penicillium roqueforti DTO012A6 (CBS 147310) Penicillium roqueforti DTO012A7 Penicillium roqueforti DTO012A8 Penicillium roqueforti DTO012A9 Penicillium roqueforti DTO013E5 Penicillium roqueforti DTO013F2 Penicillium roqueforti DTO013F5 (CBS 147311) Penicillium roqueforti DTO027I6 Penicillium roqueforti DTO032C6 Penicillium roqueforti DTO039G3 Penicillium roqueforti DTO046C5 Penicillium roqueforti DTO070G2 (CBS 147317) Penicillium roqueforti DTO081F9 (CBS 147318) Penicillium roqueforti DTO101D6 (CBS 147325) Penicillium roqueforti DTO102I9 (CBS 147326) Penicillium roqueforti DTO126G2 (CBS 147330) Penicillium roqueforti DTO127F7 (CBS 147331) Penicillium roqueforti DTO127F9 (CBS 147332) Penicillium roqueforti DTO130C1 (CBS 147333) Penicillium roqueforti DTO163C3 (CBS 147337) Penicillium roqueforti DTO163F5 (CBS 147338) Penicillium roqueforti DTO163G4 (CBS 147339) Penicillium roqueforti DTO265D5 (CBS 147372) Penicillium roqueforti DTO369A1 (CBS 147354) Penicillium roqueforti DTO375B1 (CBS 147355) Penicillium roqueforti DTO377G2 (LCP 96.3914a) Penicillium roqueforti LCP96 04111 Rhodonia placenta FPRL280 Torrubiellomyces zombiae CBS 149187

General Properties

Protein ID	AgabiH97|012160
Gene name
Location	scaffold_1:2892434..2894503
Strand	+
Gene length (bp)	2069
Transcript length (bp)	1404
Coding sequence length (bp)	1404
Protein length (aa)	468

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PFAM Domains

PFAM Domain ID	Short name	Long name	E-value	Start	End
PF05978	UNC-93	Ion channel regulatory protein UNC-93	3.1E-19	75	407
PF07690	MFS_1	Major Facilitator Superfamily	2.1E-13	75	408

Swissprot hits

Swissprot ID	Swissprot Description	Start	End	E-value
sp|Q9URX1|YLX5_SCHPO	UNC93-like protein C922.05c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC922.05c PE=3 SV=1	18	460	1.0E-136
sp|Q8LG53|UN932_ARATH	UNC93-like protein 2 OS=Arabidopsis thaliana GN=At1g18010 PE=2 SV=2	28	447	2.0E-103
sp|Q56WD3|UN931_ARATH	UNC93-like protein 1 OS=Arabidopsis thaliana GN=At1g18000 PE=2 SV=2	28	447	2.0E-103
sp|O14237|YEL4_SCHPO	Uncharacterized membrane protein C6F6.04c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC6F6.04c PE=4 SV=1	34	462	2.0E-51

GO

GO Term	Description	Terminal node
GO:0055085	transmembrane transport	Yes
GO:0022857	transmembrane transporter activity	Yes
GO:0051179	localization	No
GO:0003674	molecular_function	No
GO:0051234	establishment of localization	No
GO:0008150	biological_process	No
GO:0009987	cellular process	No
GO:0005215	transporter activity	No
GO:0006810	transport	No

SignalP

[Help with interpreting these statistics]

SignalP signal predicted	Location (based on Ymax)	D score (significance: > 0.45)
No	1 - 52	0.5

Transmembrane Domains

Domain #	Start	End	Length
1	37	59	22
2	69	91	22
3	96	118	22
4	123	145	22
5	158	180	22
6	190	212	22
7	249	266	17
8	286	303	17
9	315	334	19
10	362	384	22
11	391	413	22
12	423	445	22

Transcription Factor Class

(None)

Expression data

Analysis 1: Developmental stages of Agaricus bisporus (strain A15). Published in Pelkmans et al, Applied Microbiology and Biotechnology, 2016

Expression values

Label	Description	Expression (RPKM)	Confidence interval (low)	Confidence interval (high)
Casing	Casing mycelium	529.40	211.59	847.21
Initials	Initials knots	158.63	93.35	223.91
Pileal_Stipeal_center	Stage I stipe center	51.22	30.35	72.10
Pileal_Stipeal_shell	Stage I stipe shell	16.91	8.95	24.86
DIF_stipe_center	Stage II stipe center	49.02	28.56	69.47
DIF_stipe_shell	Stage II stipe shell	85.65	50.81	120.49
DIF_stipe_skin	Stage II stipe skin	62.87	36.09	89.65
DIF_cap_skin	Stage II cap skin	9.74	4.81	14.67
DIF_cap_tissue	Stage II cap tissue	15.20	7.97	22.44
DIF_gill_tissue	Stage II gill tissue	19.32	10.47	28.17
YFB_stipe_center	Young fruiting body stipe center	107.54	63.22	151.87
YFB_stipe_shell	Young fruiting body stipe shell	105.31	62.73	147.88
YFB_stipe_skin	Young fruiting body stipe skin	56.13	33.29	78.96
YFB_cap_skin	Young fruiting body cap skin	7.71	3.67	11.75
YFB_cap_tissue	Young fruiting body cap tissue	11.14	5.62	16.65
YFB_gill_tissue	Young fruiting body gill tissue	16.80	8.90	24.69
YFB_veil	Young fruiting body veil	18.01	9.66	26.37

Differential expression

Label1	Label2	Q-value	Significant difference
Casing	DIF_gill_tissue	0.000613	yes
Casing	YFB_stipe_center	0.000613	yes
Casing	YFB_stipe_shell	0.000613	yes
Casing	YFB_stipe_skin	0.000613	yes
Casing	YFB_cap_skin	0.000613	yes
Casing	YFB_cap_tissue	0.000613	yes
Casing	YFB_gill_tissue	0.000613	yes
Casing	YFB_veil	0.000613	yes
Casing	Initials	0.000613	yes
Casing	Pileal_Stipeal_center	0.000613	yes
Casing	Pileal_Stipeal_shell	0.000613	yes
Casing	DIF_stipe_center	0.000613	yes
Casing	DIF_stipe_shell	0.000613	yes
Casing	DIF_stipe_skin	0.000613	yes
Casing	DIF_cap_skin	0.000613	yes
Casing	DIF_cap_tissue	0.000613	yes
DIF_gill_tissue	YFB_stipe_center	0.000613	yes
DIF_gill_tissue	YFB_stipe_shell	0.000613	yes
DIF_gill_tissue	YFB_stipe_skin	0.000613	yes
DIF_gill_tissue	YFB_cap_skin	0.003365	yes
DIF_gill_tissue	YFB_cap_tissue	0.086247	no
DIF_gill_tissue	YFB_gill_tissue	0.783552	no
DIF_gill_tissue	YFB_veil	0.905191	no
YFB_stipe_center	YFB_stipe_shell	0.970225	no
YFB_stipe_center	YFB_stipe_skin	0.013186	yes
YFB_stipe_center	YFB_cap_skin	0.000613	yes
YFB_stipe_center	YFB_cap_tissue	0.000613	yes
YFB_stipe_center	YFB_gill_tissue	0.000613	yes
YFB_stipe_center	YFB_veil	0.000613	yes
YFB_stipe_shell	YFB_stipe_skin	0.016386	yes
YFB_stipe_shell	YFB_cap_skin	0.000613	yes
YFB_stipe_shell	YFB_cap_tissue	0.000613	yes
YFB_stipe_shell	YFB_gill_tissue	0.000613	yes
YFB_stipe_shell	YFB_veil	0.000613	yes
YFB_stipe_skin	YFB_cap_skin	0.000613	yes
YFB_stipe_skin	YFB_cap_tissue	0.000613	yes
YFB_stipe_skin	YFB_gill_tissue	0.000613	yes
YFB_stipe_skin	YFB_veil	0.000613	yes
YFB_cap_skin	YFB_cap_tissue	0.351080	no
YFB_cap_skin	YFB_gill_tissue	0.017783	yes
YFB_cap_skin	YFB_veil	0.005671	yes
YFB_cap_tissue	YFB_gill_tissue	0.252511	no
YFB_cap_tissue	YFB_veil	0.148373	no
YFB_gill_tissue	YFB_veil	0.910001	no
Initials	DIF_gill_tissue	0.000613	yes
Initials	YFB_stipe_center	0.199377	no
Initials	YFB_stipe_shell	0.166579	no
Initials	YFB_stipe_skin	0.000613	yes
Initials	YFB_cap_skin	0.000613	yes
Initials	YFB_cap_tissue	0.000613	yes
Initials	YFB_gill_tissue	0.000613	yes
Initials	YFB_veil	0.000613	yes
Initials	Pileal_Stipeal_center	0.000613	yes
Initials	Pileal_Stipeal_shell	0.000613	yes
Initials	DIF_stipe_center	0.000613	yes
Initials	DIF_stipe_shell	0.015529	yes
Initials	DIF_stipe_skin	0.000613	yes
Initials	DIF_cap_skin	0.000613	yes
Initials	DIF_cap_tissue	0.000613	yes
Pileal_Stipeal_center	DIF_gill_tissue	0.000613	yes
Pileal_Stipeal_center	YFB_stipe_center	0.001625	yes
Pileal_Stipeal_center	YFB_stipe_shell	0.002951	yes
Pileal_Stipeal_center	YFB_stipe_skin	0.848865	no
Pileal_Stipeal_center	YFB_cap_skin	0.000613	yes
Pileal_Stipeal_center	YFB_cap_tissue	0.000613	yes
Pileal_Stipeal_center	YFB_gill_tissue	0.000613	yes
Pileal_Stipeal_center	YFB_veil	0.000613	yes
Pileal_Stipeal_center	Pileal_Stipeal_shell	0.000613	yes
Pileal_Stipeal_center	DIF_stipe_center	0.933586	no
Pileal_Stipeal_center	DIF_stipe_shell	0.057155	no
Pileal_Stipeal_center	DIF_stipe_skin	0.590358	no
Pileal_Stipeal_center	DIF_cap_skin	0.000613	yes
Pileal_Stipeal_center	DIF_cap_tissue	0.000613	yes
Pileal_Stipeal_shell	DIF_gill_tissue	0.796012	no
Pileal_Stipeal_shell	YFB_stipe_center	0.000613	yes
Pileal_Stipeal_shell	YFB_stipe_shell	0.000613	yes
Pileal_Stipeal_shell	YFB_stipe_skin	0.000613	yes
Pileal_Stipeal_shell	YFB_cap_skin	0.015529	yes
Pileal_Stipeal_shell	YFB_cap_tissue	0.245540	no
Pileal_Stipeal_shell	YFB_gill_tissue	0.991294	no
Pileal_Stipeal_shell	YFB_veil	0.915625	no
Pileal_Stipeal_shell	DIF_stipe_center	0.000613	yes
Pileal_Stipeal_shell	DIF_stipe_shell	0.000613	yes
Pileal_Stipeal_shell	DIF_stipe_skin	0.000613	yes
Pileal_Stipeal_shell	DIF_cap_skin	0.105377	no
Pileal_Stipeal_shell	DIF_cap_tissue	0.848999	no
DIF_stipe_center	DIF_gill_tissue	0.000613	yes
DIF_stipe_center	YFB_stipe_center	0.001140	yes
DIF_stipe_center	YFB_stipe_shell	0.002084	yes
DIF_stipe_center	YFB_stipe_skin	0.757397	no
DIF_stipe_center	YFB_cap_skin	0.000613	yes
DIF_stipe_center	YFB_cap_tissue	0.000613	yes
DIF_stipe_center	YFB_gill_tissue	0.000613	yes
DIF_stipe_center	YFB_veil	0.000613	yes
DIF_stipe_center	DIF_stipe_shell	0.040279	yes
DIF_stipe_center	DIF_stipe_skin	0.492518	no
DIF_stipe_center	DIF_cap_skin	0.000613	yes
DIF_stipe_center	DIF_cap_tissue	0.000613	yes
DIF_stipe_shell	DIF_gill_tissue	0.000613	yes
DIF_stipe_shell	YFB_stipe_center	0.528695	no
DIF_stipe_shell	YFB_stipe_shell	0.577040	no
DIF_stipe_shell	YFB_stipe_skin	0.135006	no
DIF_stipe_shell	YFB_cap_skin	0.000613	yes
DIF_stipe_shell	YFB_cap_tissue	0.000613	yes
DIF_stipe_shell	YFB_gill_tissue	0.000613	yes
DIF_stipe_shell	YFB_veil	0.000613	yes
DIF_stipe_shell	DIF_stipe_skin	0.348154	no
DIF_stipe_shell	DIF_cap_skin	0.000613	yes
DIF_stipe_shell	DIF_cap_tissue	0.000613	yes
DIF_stipe_skin	DIF_gill_tissue	0.000613	yes
DIF_stipe_skin	YFB_stipe_center	0.057550	no
DIF_stipe_skin	YFB_stipe_shell	0.066956	no
DIF_stipe_skin	YFB_stipe_skin	0.806264	no
DIF_stipe_skin	YFB_cap_skin	0.000613	yes
DIF_stipe_skin	YFB_cap_tissue	0.000613	yes
DIF_stipe_skin	YFB_gill_tissue	0.000613	yes
DIF_stipe_skin	YFB_veil	0.000613	yes
DIF_stipe_skin	DIF_cap_skin	0.000613	yes
DIF_stipe_skin	DIF_cap_tissue	0.000613	yes
DIF_cap_skin	DIF_gill_tissue	0.027205	yes
DIF_cap_skin	YFB_stipe_center	0.000613	yes
DIF_cap_skin	YFB_stipe_shell	0.000613	yes
DIF_cap_skin	YFB_stipe_skin	0.000613	yes
DIF_cap_skin	YFB_cap_skin	0.636479	no
DIF_cap_skin	YFB_cap_tissue	0.809222	no
DIF_cap_skin	YFB_gill_tissue	0.104432	no
DIF_cap_skin	YFB_veil	0.055381	no
DIF_cap_skin	DIF_cap_tissue	0.217865	no
DIF_cap_tissue	DIF_gill_tissue	0.571041	no
DIF_cap_tissue	YFB_stipe_center	0.000613	yes
DIF_cap_tissue	YFB_stipe_shell	0.000613	yes
DIF_cap_tissue	YFB_stipe_skin	0.000613	yes
DIF_cap_tissue	YFB_cap_skin	0.040279	yes
DIF_cap_tissue	YFB_cap_tissue	0.433679	no
DIF_cap_tissue	YFB_gill_tissue	0.860145	no
DIF_cap_tissue	YFB_veil	0.722590	no

Sequences

Type of sequence	Sequence
Locus	Download genbank file of locus The gene with 5 kb flanks (if sufficient flanking sequence is available). For use in cloning design programs. NOTE: features (genes or exons) that are only partially contained within the sequence are completely excluded.
Protein	>AgabiH97|012160 MNDQEKPDGTDTSSQVYYERPKGLRGLYSHPLTQVTILGLVCFMCPGLFNALTGLGGGGQVDPITNDHANVALNA TFSVAAFFAGSINNILGARLTLFIGSCGYALYIGSYLALNIHSNARGFVVGAGAILGICAGLLWTAQGSLMLAYP TEIQKGRYISIFWAIFNLGGVVGASVSLGTNYNSKANAVGNGTYIGFLVLTLCGTILPLVMVDPKNMIRSDGTKV TVSKQPSWRTELMRLPRAIRKDPMIILLFPMFLASNWFYTWQFTDYNGAIFNIRARALNNVVYWLAQIVGSILVG LVLDSKRLRRRIRAFTGWGILFALIWVVHIWGYFYQRQYTRESLSKTDIRMDIFDAPYGGRIMLYIMCGILDATW QVTTYWIMGAMSNDASTLAYLIGFYKSIQSAGAAGAWAADSRKEPYMNLFVSTWVILLAGLFFALPMIYWRVTDQ TDTTPDDNTPSDSKADA*
Coding	>AgabiH97|012160 ATGAACGACCAAGAGAAACCCGACGGCACTGATACAAGTTCTCAGGTCTATTATGAACGCCCCAAAGGGCTCAGG GGACTGTATTCTCACCCATTAACTCAGGTGACGATACTTGGCCTCGTTTGTTTCATGTGTCCAGGTCTCTTCAAC GCCCTTACTGGATTGGGAGGAGGTGGCCAAGTCGACCCCATAACTAACGATCATGCAAACGTGGCACTTAATGCT ACGTTTTCGGTCGCCGCATTTTTTGCTGGATCCATAAACAATATACTTGGTGCCCGGCTCACTTTATTCATTGGA AGCTGTGGTTATGCCCTGTACATTGGTTCATATCTGGCTTTGAACATCCACTCCAATGCCCGCGGTTTCGTGGTC GGGGCTGGCGCTATCCTTGGAATATGTGCTGGTCTGCTATGGACTGCTCAGGGTTCCCTCATGTTAGCATACCCA ACAGAAATTCAGAAAGGTCGCTACATCAGTATCTTCTGGGCCATTTTCAACTTGGGCGGAGTTGTTGGGGCATCT GTATCCCTCGGCACAAATTACAATTCCAAGGCCAACGCAGTTGGAAATGGGACATATATTGGGTTTTTGGTCCTT ACACTATGTGGGACTATCCTCCCCCTTGTCATGGTAGATCCGAAGAATATGATCAGATCAGATGGAACGAAAGTT ACCGTCTCCAAACAACCTTCTTGGAGGACAGAACTCATGAGGCTCCCCCGCGCCATTAGGAAAGATCCTATGATC ATATTGCTGTTCCCTATGTTCCTTGCTTCAAACTGGTTCTACACTTGGCAATTCACTGACTACAACGGTGCCATC TTCAACATCAGAGCGCGTGCCTTGAACAACGTCGTATACTGGCTGGCACAAATTGTGGGGTCGATTCTCGTCGGA TTGGTCCTCGACAGCAAGCGCCTTCGTCGAAGAATCAGGGCCTTCACTGGCTGGGGTATTCTCTTTGCTCTTATA TGGGTCGTCCACATCTGGGGCTACTTTTATCAGAGGCAATATACCCGCGAGTCACTTAGCAAGACTGATATCAGG ATGGATATCTTTGATGCGCCGTACGGAGGAAGAATTATGCTGTATATCATGTGTGGCATTTTGGACGCTACATGG CAAGTAACGACGTATTGGATCATGGGCGCCATGTCGAACGACGCTTCCACACTAGCATACCTCATTGGATTTTAT AAATCTATCCAATCTGCAGGAGCCGCAGGAGCCTGGGCTGCGGACAGTCGCAAAGAACCATACATGAACTTATTC GTTTCCACTTGGGTTATTCTCTTGGCTGGCCTCTTCTTTGCTCTGCCGATGATTTACTGGCGTGTCACTGATCAG ACAGATACTACTCCGGATGATAACACGCCATCCGATTCGAAGGCGGACGCTTGA
Transcript	>AgabiH97|012160 ATGAACGACCAAGAGAAACCCGACGGCACTGATACAAGTTCTCAGGTCTATTATGAACGCCCCAAAGGGCTCAGG GGACTGTATTCTCACCCATTAACTCAGGTGACGATACTTGGCCTCGTTTGTTTCATGTGTCCAGGTCTCTTCAAC GCCCTTACTGGATTGGGAGGAGGTGGCCAAGTCGACCCCATAACTAACGATCATGCAAACGTGGCACTTAATGCT ACGTTTTCGGTCGCCGCATTTTTTGCTGGATCCATAAACAATATACTTGGTGCCCGGCTCACTTTATTCATTGGA AGCTGTGGTTATGCCCTGTACATTGGTTCATATCTGGCTTTGAACATCCACTCCAATGCCCGCGGTTTCGTGGTC GGGGCTGGCGCTATCCTTGGAATATGTGCTGGTCTGCTATGGACTGCTCAGGGTTCCCTCATGTTAGCATACCCA ACAGAAATTCAGAAAGGTCGCTACATCAGTATCTTCTGGGCCATTTTCAACTTGGGCGGAGTTGTTGGGGCATCT GTATCCCTCGGCACAAATTACAATTCCAAGGCCAACGCAGTTGGAAATGGGACATATATTGGGTTTTTGGTCCTT ACACTATGTGGGACTATCCTCCCCCTTGTCATGGTAGATCCGAAGAATATGATCAGATCAGATGGAACGAAAGTT ACCGTCTCCAAACAACCTTCTTGGAGGACAGAACTCATGAGGCTCCCCCGCGCCATTAGGAAAGATCCTATGATC ATATTGCTGTTCCCTATGTTCCTTGCTTCAAACTGGTTCTACACTTGGCAATTCACTGACTACAACGGTGCCATC TTCAACATCAGAGCGCGTGCCTTGAACAACGTCGTATACTGGCTGGCACAAATTGTGGGGTCGATTCTCGTCGGA TTGGTCCTCGACAGCAAGCGCCTTCGTCGAAGAATCAGGGCCTTCACTGGCTGGGGTATTCTCTTTGCTCTTATA TGGGTCGTCCACATCTGGGGCTACTTTTATCAGAGGCAATATACCCGCGAGTCACTTAGCAAGACTGATATCAGG ATGGATATCTTTGATGCGCCGTACGGAGGAAGAATTATGCTGTATATCATGTGTGGCATTTTGGACGCTACATGG CAAGTAACGACGTATTGGATCATGGGCGCCATGTCGAACGACGCTTCCACACTAGCATACCTCATTGGATTTTAT AAATCTATCCAATCTGCAGGAGCCGCAGGAGCCTGGGCTGCGGACAGTCGCAAAGAACCATACATGAACTTATTC GTTTCCACTTGGGTTATTCTCTTGGCTGGCCTCTTCTTTGCTCTGCCGATGATTTACTGGCGTGTCACTGATCAG ACAGATACTACTCCGGATGATAACACGCCATCCGATTCGAAGGCGGACGCTTGA
Gene	>AgabiH97|012160 ATGAACGACCAAGAGAAACCCGACGGCACTGATACAAGTTCTCAGGTCTATTATGAACGCCCCAAAGGGCTCAGG GGACTGTATTCTCACCCATTAACTCAGGTCCTATATTTTTTTCTTTCTCATCGGCGACGAATCTGAAGCTACGCA GGTGACGATACTTGGCCTCGTTTGTTTCATGTGTCCAGGTATGAGCTAGTCTCAAGACTGGTAATGATGATCGCT GACACGCCGTAACAGGTCTCTTCAACGCCCTTACTGGATTGGGAGGAGGTGGCCAAGTCGACCCCATAACTAACG ATCATGCAAACGTGGCACTTAATGCTACGTTTTCGGTCGCCGCATTTTTTGCTGGGTATGCGTATCATCTCTTTC GCATCTTGTATGGTCACTCGACCAATGCCTAATTGATATAATTTTACAGATCCATAAACAATATACTTGGTGCCC GGCTCACTTTATTCATTGGAAGCTGTGGTTATGCCCTGTACATTGGTTCATATCTGTGAGTGTCACCAACTACAT GAACGATTGACTGATGTTTTGAACTTTTCTCACAGGGCTTTGAACATCCACTCCAATGCCCGCGGTTTCGTGGTC GGGGCTGGCGCTATCCTTGGAATATGTGCTGGTCTGCTATGGACTGCTCAGGGTTCCCTCATGTTAGCATACCCA ACAGAAATTCAGAAAGGTCGCTACATCAGTATCTTCTGGGCCATTTTCAACTTGGGCGGAGTTGTTGGGGCATCT GTATCCCTCGGCACAAATTACAATTCCAAGGTTCGTCCTCCTGGCATTCGTGGTTTCACATGTATTGACCTTATT TATTGTAGGCCAACGCAGGTACGTTTATCGGTTCGAAATATTGGCTGTGCAATTCTAAACATAAGCACCTCCAGT TGGAAATGGGACATATGTCAGTCGAATTTACCCCTTTATAGAGTATCAGAAGACTAACGTATCGAAAGATTGGGT TTTTGGTCCTTACACTATGTGGGACTATCCTCCCCCTTGTCATGGTAGATCCGAAGAATATGATCAGATCAGATG GAACGAAAGTTACCGTCTCCAAACAACCTTCTTGGAGGACAGAACTCATGAGGCTCCCCCGCGCCATTAGGAAAG ATCCTATGATCATATTGCTGTTCCCTATGTTCCTTGCTTCAAACTGGTTCTACACTTGGCGTATGAATATCACCT TACATCGATATTACTCAACTACTAATGCTCATAACCATAGAATTCACTGACTACAACGGTGCCATCTTCAACATC AGAGCGCGTGCCTTGAACAACGTCGTATACTGGCTGGCACAAATTGTGGGGTCGATTCTCGTCGGATTGGTCCTC GACAGCAAGCGCCTTCGTCGAAGAATCAGGGCCTTCACTGGCTGGGGTATTCTCTTTGCTCTTATATGGGTCGTC CACATCTGGGGCTACTTTTATCAGAGGTGAGTACAAGTCGAGCCAGAAAGAAACGTGACTAATTCAATTGCTGTA CAGGCAATATACCCGCGAGTCACTTAGCAAGACTGATATCAGGATGGATATCTTTGATGCGCCGTACGGAGGAAG AATTATGCTGTATATCATGTGTGGCATTTTGGACGCTACATGGCAAGTAACGACGTATTGGATCATGGGCGCCAT GTCGAACGACGCTTCCACACTAGCATACCTCATTGGATTTTGTGAGCTTCTCCTAATATTCGCAGATAGTCATAA CGCGTTACTGATTGAACCCTAGATAAATCTATCCAATCTGCAGGAGCCGCAGGAGCCTGGGCTGCGGACAGTCGC AAAGAACCGTGAGTTGCCTTTTTCCCCTAGCCTCCATCTGGATTCGTGTCTTGACGCAATTCGACTAGATACATG AACTTATTCGTTTCCACTTGGGTTATTCTCTTGGCTGGCCTCTTCTTTGCTCTGCCGATGATTTACTGGCGTGTC ACTGATCAGACAGATACTACTCCGGATGATAACACGTGAGTAATGGTCATTCATCAGAAAATACATCACACTGAA GTATAAATCAATGCAGGCCATCCGATTCGAAGGCGGACGCTTGA